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Articles 63901 - 63930 of 325330

Full-Text Articles in Medicine and Health Sciences

Two-Year Clinical Performance Of The Indirect Resin Composite Restorations In Endodontically Treated Teeth With Different Cavity Preparation Designs: A Randomized Clinical Trial., Hend Sayed Ahmed, Mohamed Fouad Haridy, Shehab Saber, Olfat Hassanien, Hoda Fouda, Maha Elbaz, Ahmed Abuelezz Jan 2024

Two-Year Clinical Performance Of The Indirect Resin Composite Restorations In Endodontically Treated Teeth With Different Cavity Preparation Designs: A Randomized Clinical Trial., Hend Sayed Ahmed, Mohamed Fouad Haridy, Shehab Saber, Olfat Hassanien, Hoda Fouda, Maha Elbaz, Ahmed Abuelezz

Dentistry

No abstract provided.


Build Angle Effect On 3d-Printed Dental Crowns Marginal Fit Using Digital Lightprocessing And Stereo-Lithography Technology: An In Vitro Study, Ahmed Sabet Jan 2024

Build Angle Effect On 3d-Printed Dental Crowns Marginal Fit Using Digital Lightprocessing And Stereo-Lithography Technology: An In Vitro Study, Ahmed Sabet

Dentistry

Background The effect of 3D printing technology and build angle on the marginal fit of printed crowns is unclear. The objective of this research was to use digital light processing (DLP) and stereo-lithography (SLA)-based 3D printing to construct single restorations with varied build angles and to analyze the crowns′ marginal fit. Methods A prepared resin first molar was scanned utilizing an optical scanner. Three build orientations were used to construct the specimens: 0, 45, and 90º. DLP and SLA technology were used to produce the casting patterns. A digital microscope was used to measure the marginal gaps. The effect of …


Prospective Validation Of A Hospital Triage Predictive Model To Decrease Undertriage: An East Multicenter Study., Elise A Biesboer, Courtney J Pokrzywa, Basil S Karam, Benjamin Chen, Aniko Szabo, Bi Qing Teng, Matthew D Bernard, Andrew Bernard, Sharfuddin Chowdhury, Al-Hasher E Hayudini, Michal A Radomski, Stephanie Doris, Brian K Yorkgitis, Jennifer Mull, Benjamin W Weston, Mark R Hemmila, Christopher J Tignanelli, Marc A De Moya, Rachel S Morris Jan 2024

Prospective Validation Of A Hospital Triage Predictive Model To Decrease Undertriage: An East Multicenter Study., Elise A Biesboer, Courtney J Pokrzywa, Basil S Karam, Benjamin Chen, Aniko Szabo, Bi Qing Teng, Matthew D Bernard, Andrew Bernard, Sharfuddin Chowdhury, Al-Hasher E Hayudini, Michal A Radomski, Stephanie Doris, Brian K Yorkgitis, Jennifer Mull, Benjamin W Weston, Mark R Hemmila, Christopher J Tignanelli, Marc A De Moya, Rachel S Morris

Trauma and Acute Care Articles

BACKGROUND: Tiered trauma team activation (TTA) allows systems to optimally allocate resources to an injured patient. Target undertriage and overtriage rates of

METHODS: The model was previously developed and internally validated using data from 31 US trauma centers. Data were collected prospectively at five sites using a mobile application which hosted the NEI-6 model. A weighted multiple logistic regression model was used to retrain and optimize the model using the original data set and a portion of data from one of the prospective sites. The remaining data from the five sites were designated for external validation. The area under the …


Failure Rates Of Nonoperative Management Of Low-Grade Splenic Injuries With Active Extravasation: An Eastern Association For The Surgery Of Trauma Multicenter Study., Kristen Spoor, John David Cull, Banan W Otaibi, Joshua P Hazelton, John Chipko, Jessica Reynolds, Sam Fugate, Claire Pederson, Linda B Zier, Lewis E Jacobson, Jamie M Williams, Thomas S Easterday, Saskya Byerly, Caleb Mentzer, Edward Hawke, Daniel C Cullinane, Julianne B Ontengco, Nikolay Bugaev, Madison Leclair, Pascal Udekwu, Cooper Josephs, Matthew Noorbaksh, James Babowice, Catherine Garrison Velopulos, Shane Urban, Anna Goldenberg, Gaby Ghobrial, John M Pickering, Steven D Quarfordt, Alia F Aunchman, Aimee K Lariccia, Chance Spalding, Richard D Catalano, Jordan E Basham, Philip M Edmundson, Jeffry Nahmias, Erika Tay, Scott H Norwood, Katelyn Meadows, Yee Wong, Claire Hardman Jan 2024

Failure Rates Of Nonoperative Management Of Low-Grade Splenic Injuries With Active Extravasation: An Eastern Association For The Surgery Of Trauma Multicenter Study., Kristen Spoor, John David Cull, Banan W Otaibi, Joshua P Hazelton, John Chipko, Jessica Reynolds, Sam Fugate, Claire Pederson, Linda B Zier, Lewis E Jacobson, Jamie M Williams, Thomas S Easterday, Saskya Byerly, Caleb Mentzer, Edward Hawke, Daniel C Cullinane, Julianne B Ontengco, Nikolay Bugaev, Madison Leclair, Pascal Udekwu, Cooper Josephs, Matthew Noorbaksh, James Babowice, Catherine Garrison Velopulos, Shane Urban, Anna Goldenberg, Gaby Ghobrial, John M Pickering, Steven D Quarfordt, Alia F Aunchman, Aimee K Lariccia, Chance Spalding, Richard D Catalano, Jordan E Basham, Philip M Edmundson, Jeffry Nahmias, Erika Tay, Scott H Norwood, Katelyn Meadows, Yee Wong, Claire Hardman

Trauma and Acute Care Articles

OBJECTIVES: There is little evidence guiding the management of grade I-II traumatic splenic injuries with contrast blush (CB). We aimed to analyze the failure rate of nonoperative management (NOM) of grade I-II splenic injuries with CB in hemodynamically stable patients.

METHODS: A multicenter, retrospective cohort study examining all grade I-II splenic injuries with CB was performed at 21 institutions from January 1, 2014, to October 31, 2019. Patients >18 years old with grade I or II splenic injury due to blunt trauma with CB on CT were included. The primary outcome was the failure of NOM requiring angioembolization/operation. We determined …


Advancing The Practice Of Trauma: Utilizing Advanced Practice Providers To Improve Patient Outcomes Through A Collaborative Team Approach., Alaina M Lasinski, Allysen Shaughnessy, Benjamin Reynolds, Raquel Forsythe, Annika B Kay, Brian K Yorkgitis, Brandy N Younge, Ashley B Christmas, Jeffrey A Claridge Jan 2024

Advancing The Practice Of Trauma: Utilizing Advanced Practice Providers To Improve Patient Outcomes Through A Collaborative Team Approach., Alaina M Lasinski, Allysen Shaughnessy, Benjamin Reynolds, Raquel Forsythe, Annika B Kay, Brian K Yorkgitis, Brandy N Younge, Ashley B Christmas, Jeffrey A Claridge

Trauma and Acute Care Articles

Advanced practice providers (APPs) have become essential to trauma teams in the United States during the last few decades. The optimal utilization of APPs is not yet known and is likely highly variable secondary to many factors. We discuss three aspects of the multidisciplinary approach to caring for trauma patients. First, a review of the literature demonstrates that APPs in trauma improve quality of care, patient throughput, and decrease cost. We then report on models of APP utilization by comparing five trauma centers across the country, concluding that utilization remains highly variable due to several system and provider factors. The …


Mangement Of Hypomineralized Anterior Teeth In Children And Adults, Shadwa Kabil, Sarah M.S. Khalil Jan 2024

Mangement Of Hypomineralized Anterior Teeth In Children And Adults, Shadwa Kabil, Sarah M.S. Khalil

Dentistry

No abstract provided.


Evaluation Of The Efficiency Of Passive Self-Ligating Versus Conventional Brackets In The Alignment Of Mandibular Crowded Teeth (A Comparative Study), Noha Ibrahim Abdelrahman Professor Jan 2024

Evaluation Of The Efficiency Of Passive Self-Ligating Versus Conventional Brackets In The Alignment Of Mandibular Crowded Teeth (A Comparative Study), Noha Ibrahim Abdelrahman Professor

Dentistry

Aim: Is to compare the efficiency of passive self-ligating versus conventional brackets in the alignment of crowded mandibular teeth. Materials and methods: A randomized clinical trial with Fifty participants visiting the clinic of the Orthodontic Department and fulfilling the eligibility criteria were enrolled in the study. Patients were randomly allocated to group A (Conventional brackets) or group B (Damon Q metal passive self-ligating brackets). The amount of mandibular crowding was assessed by Little’s irregularity index. Subjects in both groups were recalled for follow-up every four weeks till completion of alignment. Results: There was no significant difference in baseline irregularity in …


Invitro Evaluation Of Forces Delivered By Aligners Fabricated Using Positive Air Pressure Versus Negative Air Pressure., Islam Tarek Abbas Hassan Ahmed Prof, Nada Hamed, Dina Elghoul, Ahmed Zaki, Iman El-Abbasy Jan 2024

Invitro Evaluation Of Forces Delivered By Aligners Fabricated Using Positive Air Pressure Versus Negative Air Pressure., Islam Tarek Abbas Hassan Ahmed Prof, Nada Hamed, Dina Elghoul, Ahmed Zaki, Iman El-Abbasy

Dentistry

No abstract provided.


Family Structure, Family Transitions, And Child Overweight And Obesity: Comparing Australia, The United Kingdom, And The United States, Sadie A. Slighting, Kirsten Rasmussen, Mikaela J. Dufur, Jonathan A. Jarvis, Shana Pribesh, Alyssa J. Alexander, Carolina Otero Jan 2024

Family Structure, Family Transitions, And Child Overweight And Obesity: Comparing Australia, The United Kingdom, And The United States, Sadie A. Slighting, Kirsten Rasmussen, Mikaela J. Dufur, Jonathan A. Jarvis, Shana Pribesh, Alyssa J. Alexander, Carolina Otero

STEMPS Faculty Publications

Growing rates of childhood obesity globally create concern for individuals' health outcomes and demands on health systems. While many policy approaches focus on macro-level interventions, we examine how the type of stability of a family structure might provide opportunities for policy interventions at the micro level. We examine the association between family structure trajectories and childhood overweight and obesity across three Anglophone countries using an expanded set of eight family structure categories that capture biological relationships and instability, along with potential explanatory variables that might vary across family trajectories and provide opportunities for intervention, including access to resources, family stressors, …


Machine Learning As A Tool For Early Detection: A Focus On Late-Stage Colorectal Cancer Across Socioeconomic Spectrums, Hadiza Galadima, Rexford Anson-Dwamena, Ashley Johnson, Ghalib Bello, Georges Adunlin, James Blando Jan 2024

Machine Learning As A Tool For Early Detection: A Focus On Late-Stage Colorectal Cancer Across Socioeconomic Spectrums, Hadiza Galadima, Rexford Anson-Dwamena, Ashley Johnson, Ghalib Bello, Georges Adunlin, James Blando

Community & Environmental Health Faculty Publications

Purpose: To assess the efficacy of various machine learning (ML) algorithms in predicting late-stage colorectal cancer (CRC) diagnoses against the backdrop of socio-economic and regional healthcare disparities. Methods: An innovative theoretical framework was developed to integrate individual- and census tract-level social determinants of health (SDOH) with sociodemographic factors. A comparative analysis of the ML models was conducted using key performance metrics such as AUC-ROC to evaluate their predictive accuracy. Spatio-temporal analysis was used to identify disparities in late-stage CRC diagnosis probabilities. Results: Gradient boosting emerged as the superior model, with the top predictors for late-stage CRC diagnosis being anatomic site, …


A New Approach For Discriminating Spatially Acquired Sers Spectra Using Antiretroviral Drug Emtricitabine As A Test Sample, Jana Hrncirova, Marguerite R. Butler, Meredith R. Clark, Gustavo F. Doncel, John B. Cooper Jan 2024

A New Approach For Discriminating Spatially Acquired Sers Spectra Using Antiretroviral Drug Emtricitabine As A Test Sample, Jana Hrncirova, Marguerite R. Butler, Meredith R. Clark, Gustavo F. Doncel, John B. Cooper

Chemistry & Biochemistry Faculty Publications

In this study, an antiretroviral drug emtricitabine (also known as FTC or Emtriva) was detected and quantified down to 40 ng/ml by using surface-enhanced Raman spectroscopy (SERS). Its aqueous standards were tested with two types of silver nanoparticles (colloidal and dendritic) using a specially developed aluminum well plate. The SERS spectra were acquired using a Raman scanning device with 30-mu m spatial resolution. The spectral data were analyzed using a new approach for the discrimination of the spatially acquired spectra based on the Quality index (Qi). After the Qi is calculated, the spectral data are sorted based on the Qi. …


Breastfeeding Perceptions And Decisions Among Hispanic Participants In The Special Supplemental Nutrition Program For Women, Infants, And Children: A Qualitative Study, Emily Fisher, Priyanka Patel, Kathryn G. Wouk, Bidusha Neupane, Futun Alkhalifah, Marilyn M. Bartholmae, Chuanyi Tang, Qi Zhang Jan 2024

Breastfeeding Perceptions And Decisions Among Hispanic Participants In The Special Supplemental Nutrition Program For Women, Infants, And Children: A Qualitative Study, Emily Fisher, Priyanka Patel, Kathryn G. Wouk, Bidusha Neupane, Futun Alkhalifah, Marilyn M. Bartholmae, Chuanyi Tang, Qi Zhang

Community & Environmental Health Faculty Publications

The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is a nutrition assistance program in the U.S. WIC served 2.5 million eligible Hispanic women, infants, and children under the age of five in 2021, which is WIC's largest racial/ethnic group. However, limited research has been conducted to understand Hispanic WIC participants' perceptions of WIC breastfeeding recommendations and their breastfeeding decisions. For this qualitative study, we interviewed 18 of these pregnant and postpartum WIC participants on their experiences and decision-making processes related to breastfeeding. Hispanic cultures and home country norms were identified as prominent influences on breastfeeding decisions, along …


Navigating New Normals: Student Perceptions, Experiences, And Mental Health Service Utilization In Post-Pandemic Academia, Hadiza Galadima, Anne Dumadag, Cara Tonn Jan 2024

Navigating New Normals: Student Perceptions, Experiences, And Mental Health Service Utilization In Post-Pandemic Academia, Hadiza Galadima, Anne Dumadag, Cara Tonn

Community & Environmental Health Faculty Publications

This study explores the profound impacts of the COVID-19 pandemic on higher education, focusing on shifts in learning experiences and students’ intentions to utilize mental health services post-pandemic. Utilizing Andersen’s Behavioral Model of Health Services Use, this study assesses perceptions from a stratified random sample of college students on post-pandemic learning experiences and mental health service utilization intentions. Findings reveal a positive reception to university initiatives and a preference for ongoing virtual classes. There is an evident increase in, and varying intentions for, using mental health services, shaped by demographics, employment, and prior service utilization. Younger and female students showed …


The Association Of Skin Cancer Prevention Knowledge, Sun-Protective Attitudes, And Sun-Protective Behaviors In A Navy Population, Rachel Newnam, Uyen Le-Jenkins, Carolyn Rutledge, Craig Cunningham Jan 2024

The Association Of Skin Cancer Prevention Knowledge, Sun-Protective Attitudes, And Sun-Protective Behaviors In A Navy Population, Rachel Newnam, Uyen Le-Jenkins, Carolyn Rutledge, Craig Cunningham

Ellmer School of Nursing Faculty Publications

Introduction: U.S. Navy service members are primarily between the ages of 18 and 30 years and often required to be outside for extended periods of time in geographical locations with increased and often unfamiliar ultraviolet indexes that collectively increase their risk for skin cancer. Skin cancer is the country's most common form of cancer, yet there is a paucity of skin cancer prevention literature, especially within the U.S. Navy. The purpose of this study was to describe skin cancer risk and skin cancer prevention "cues-to-action" and to determine if skin cancer prevention knowledge was associated with sun-protective attitudes (e.g., prevention …


Evidence Of Direct Interaction Between Cisplatin And The Caspase-Cleaved Prostate Apoptosis Response-4 Tumor Suppressor, Krishna K. Raut, Samjhana Pandey, Gyanendra Kharel, Steven M. Pascal Jan 2024

Evidence Of Direct Interaction Between Cisplatin And The Caspase-Cleaved Prostate Apoptosis Response-4 Tumor Suppressor, Krishna K. Raut, Samjhana Pandey, Gyanendra Kharel, Steven M. Pascal

Chemistry & Biochemistry Faculty Publications

Prostate apoptosis response-4 (Par-4) tumor suppressor protein has gained attention as a potential therapeutic target owing to its unique ability to selectively induce apoptosis in cancer cells, sensitize them to chemotherapy and radiotherapy, and mitigate drug resistance. It has recently been reported that Par-4 interacts synergistically with cisplatin, a widely used anticancer drug. However, the mechanistic details underlying this relationship remain elusive. In this investigation, we employed an array of biophysical techniques, including circular dichroism spectroscopy, dynamic light scattering, and UV–vis absorption spectroscopy, to characterize the interaction between the active caspase-cleaved Par-4 (cl-Par-4) fragment and cisplatin. Additionally, elemental analysis was …


Synthetic Approaches Of Carbohydrate Based Self-Assembling Systems, Guijun Wang, Anji Chen, Pramod Aryal, Jonathan Bietsch Jan 2024

Synthetic Approaches Of Carbohydrate Based Self-Assembling Systems, Guijun Wang, Anji Chen, Pramod Aryal, Jonathan Bietsch

Chemistry & Biochemistry Faculty Publications

Carbohydrate-based self-assembling systems are essential for the formation of advanced biocompatible materials via a bottom-up approach. The self-assembling of sugar-based small molecules has applications encompassing many research fields and has been studied extensively. In this focused review, we will discuss the synthetic approaches for carbohydrate-based self-assembling (SA) systems, the mechanisms of the assembly, as well as the main properties and applications. This review will mainly cover recent publications in the last four years from January 2020 to December 2023. We will essentially focus on small molecule self-assembly, excluding polymer-based systems, which include various derivatives of monosaccharides, disaccharides, and oligosaccharides. Glycolipids, …


Unraveling The Complex Interactions Among Lung Cancer, Copd, Cardiovascular Disease, And Pulmonary Fibrosis: Overlapping Risks, Converging Pathways, And Integrated Care Approaches, Daisy Umutoni, Mayowa Soloman Owolabi, Sakariyau Adio Waheed Jan 2024

Unraveling The Complex Interactions Among Lung Cancer, Copd, Cardiovascular Disease, And Pulmonary Fibrosis: Overlapping Risks, Converging Pathways, And Integrated Care Approaches, Daisy Umutoni, Mayowa Soloman Owolabi, Sakariyau Adio Waheed

Chemistry & Biochemistry Faculty Publications

Background: The coexistence of lung cancer, chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD), and pulmonary fibrosis poses significant challenges in clinical management due to shared risk factors, overlapping pathogenic mechanisms, and the complexity of co-managing multimorbid conditions. Smoking, environmental exposures, and genetic predispositions are critical shared risk factors, while common molecular mechanisms such as oxidative stress, chronic inflammation, and aberrant tissue remodeling contribute to the pathogenesis of these diseases. This review comprehensively examines the prevalence, shared mechanisms, and clinical implications of these comorbid conditions, emphasizing the importance of integrated management strategies to improve patient outcomes. We further highlight research …


Photoluminescence Switching In Quantum Dots Connected With Carboxylic Acid And Thiocarboxylic Acid End-Group Diarylethene Molecules, Ephraiem S. Sarabamoun, Pramod Aryal, Jonathan M. Bietsch, Maurice Curran, Sugandha Verma, Grayson Johnson, Lucy U. Yoon, Amelia G. Reid, Esther H. R. Tsai, Charles W. Machan, Christopher Paolucci, Guijun Wang, Joshua J. Choi Jan 2024

Photoluminescence Switching In Quantum Dots Connected With Carboxylic Acid And Thiocarboxylic Acid End-Group Diarylethene Molecules, Ephraiem S. Sarabamoun, Pramod Aryal, Jonathan M. Bietsch, Maurice Curran, Sugandha Verma, Grayson Johnson, Lucy U. Yoon, Amelia G. Reid, Esther H. R. Tsai, Charles W. Machan, Christopher Paolucci, Guijun Wang, Joshua J. Choi

Chemistry & Biochemistry Faculty Publications

We contrast the switching of photoluminescence (PL) of PbS quantum dots (QDs) cross-linked with photochromic diarylethene molecules with different end groups, 4,4′-(1-cyclopentene-1,2-diyl)bis[5-methyl-2-thiophenecarboxylic acid] (1C) and 4,4′-(1-cyclopentene-1,2-diyl)bis[5-methyl-2-thiophenethiocarboxylic acid] (2T). Our results show that the QDs cross-linked with the carboxylic acid end group molecules (1C) exhibit a greater amount of switching in photoluminescence intensity compared to QDs cross-linked with the thiocarboxylic acid end group (2T). We also demonstrate that regardless of the molecule used, greater switching amounts are observed for smaller quantum dots. Varying these parameters allows for the fabrication of photoswitches with tunable PL change. We relate these observations to the …


Polarizable Amoeba Force Field Predicts Thin And Dense Hydration Layer Around Monosaccharides, Luke A. Newman, Mackenzie G. Patton, Breyanna A. Rodriguez, Ethan W. Summer, Valerie Vaissier Welbourn Jan 2024

Polarizable Amoeba Force Field Predicts Thin And Dense Hydration Layer Around Monosaccharides, Luke A. Newman, Mackenzie G. Patton, Breyanna A. Rodriguez, Ethan W. Summer, Valerie Vaissier Welbourn

Chemistry & Biochemistry Faculty Publications

Polarizable force fields crucially enhance the modeling of macromolecules in polar media. Here, we present new parameters to model six common monosaccharides with the polarizable AMOEBA force field. These parameters yield a thinner, but denser, hydration layer than that previously reported. This denser hydration layer results in eliminating non-physical aggregation of glucose in water-an issue that has plagued molecular dynamics simulations of carbohydrates for decades.


Diagnostic Certainty During In-Person And Telehealth Autism Evaluations, Natasha N. Ludwig, Calliope Holingue, Ji Su Hong, Luther G. Kalb, Danika Pfeiffer, Rachel Reetzke, Deepa Menon Jan 2024

Diagnostic Certainty During In-Person And Telehealth Autism Evaluations, Natasha N. Ludwig, Calliope Holingue, Ji Su Hong, Luther G. Kalb, Danika Pfeiffer, Rachel Reetzke, Deepa Menon

Speech-Language Pathology Faculty Publications

Background

Many diagnostic evaluations abruptly shifted to telehealth during the COVID-19 pandemic; however, little is known about the impact on diagnosis patterns for children evaluated for autism spectrum disorder (ASD). The purpose of this clinical research study was to examine (1) the frequency of diagnoses evaluated beyond ASD; (2) the frequency of diagnoses made, including ASD; and (3) clinician diagnostic certainty for all diagnoses evaluated for children who received an evaluation due to primary concerns about ASD via telehealth during the pandemic compared to those evaluated in person before the pandemic at an ASD specialty clinic.

Methods

The sample included …


Implementing A Holistic Review Toolkit For Faculty Recruitment And Retention, Toi Blakley Harris, Michelle Shader, Patrick O. Smith, Amelia Challender, Cleveland Piggott, Norma I. Poll, Ryan Henyard, Jeffrey M. Lyness, Erika D. Malmberg, Eva K. Pressman, Alicia D. Monroe, Negar N. Jacobs Jan 2024

Implementing A Holistic Review Toolkit For Faculty Recruitment And Retention, Toi Blakley Harris, Michelle Shader, Patrick O. Smith, Amelia Challender, Cleveland Piggott, Norma I. Poll, Ryan Henyard, Jeffrey M. Lyness, Erika D. Malmberg, Eva K. Pressman, Alicia D. Monroe, Negar N. Jacobs

University Administration Publications

Introduction: A diverse workforce improves health care, educational outcomes, and research agendas. Currently, faculty from historically excluded groups remain underrepresented in academic medicine. Resources are needed in academic medical centers for those charged with recruiting and retaining a diverse and talented workforce. Methods: Informed by the successful use of holistic review in medical student admissions, the Association of American Medical Colleges (AAMC) developed and piloted a toolkit for use in faculty recruitment and retention at five academic medical centers. Institutions led toolkit-guided holistic review workshops ranging from 2.5 to 3 hours in duration for leaders and faculty to identify and …


Caregivers' Perceptions Of Covid-19 Educational Disruptions On Children With Developmental Language Disorder And Typically Developing Peers, Katherine Radville, Danika Pfeiffer, Karynn Sheranian, Julie Wolter, Jessie Ricketts, Tiffany L. Hogan Jan 2024

Caregivers' Perceptions Of Covid-19 Educational Disruptions On Children With Developmental Language Disorder And Typically Developing Peers, Katherine Radville, Danika Pfeiffer, Karynn Sheranian, Julie Wolter, Jessie Ricketts, Tiffany L. Hogan

Communication Disorders & Special Education Faculty Publications

Purpose: Understanding the experiences of families of children with developmental language disorder (DLD) during COVID-19 educational disruptions is essential for designing responsive supports during pandemic recovery efforts and beyond. This qualitative study describes the experiences of families of first-and second-grade children with DLD during the pandemic as compared to the experiences of families of typically developing (TD) peers.

Method: A conventional content analysis approach was used to analyze caregivers’ written responses to open-ended questions regarding their perceptions of COVID-19 educational disruptions. Responses were analyzed separately by group: caregivers of children with DLD (n= 23) and caregivers of TD children (n= …


Listeria Adhesion Protein Orchestrates Caveolae-Mediated Apical Junctional Remodeling Of Epithelial Barrier For Listeria Monocytogenes Translocation, Rishi Drolia, Donald B. Bryant, Shivendra Tenguria, Zuri A. Jules-Culver, Jessie Thind, Breanna Amelunke, Donqi Liu, Nicholas L. F. Gallina, Krishna K. Mishra, Manalee Samaddar, Manoj R. Sawale, Dharmendra K. Mishra, Abigail D. Cox, Arun K. Bhunia Jan 2024

Listeria Adhesion Protein Orchestrates Caveolae-Mediated Apical Junctional Remodeling Of Epithelial Barrier For Listeria Monocytogenes Translocation, Rishi Drolia, Donald B. Bryant, Shivendra Tenguria, Zuri A. Jules-Culver, Jessie Thind, Breanna Amelunke, Donqi Liu, Nicholas L. F. Gallina, Krishna K. Mishra, Manalee Samaddar, Manoj R. Sawale, Dharmendra K. Mishra, Abigail D. Cox, Arun K. Bhunia

Biological Sciences Faculty Publications

The cellular junctional architecture remodeling by Listeria adhesion protein-heat shock protein 60 (LAP-Hsp60) interaction for Listeria monocytogenes (Lm) passage through the epithelial barrier is incompletely understood. Here, using the gerbil model, permissive to internalin (Inl) A/B-mediated pathways like in humans, we demonstrate that Lm crosses the intestinal villi at 48 h post-infection. In contrast, the single isogenic (lap− or ΔinlA) or double (lap−ΔinlA) mutant strains show significant defects. LAP promotes Lm translocation via endocytosis of cell-cell junctional complex in enterocytes that do not display luminal E-cadherin. In comparison, InlA facilitates …


An Automated Approach For Identifying Erroneous Is-A Relations In Snomed Ct, Ran Hu, Jay Shi, Licong Cui, Rashmie Abeysinghe Jan 2024

An Automated Approach For Identifying Erroneous Is-A Relations In Snomed Ct, Ran Hu, Jay Shi, Licong Cui, Rashmie Abeysinghe

Faculty, Staff and Student Publications

SNOMED CT is the most comprehensive clinical terminology employed worldwide and enhancing its accuracy is of utmost importance. In this work, we introduce an automated approach to identifying erroneous IS-A relations in SNOMED CT. We first extract linked concept-pairs from which we generate Term Difference Pairs (TDPs) that contain differences between the concepts. Given a TDP, if the reversed TDP also exists and the number of linked-pairs generating this TDP is less than those generating the reversed TDP, then we suggest the former linked-pairs as potentially erroneous IS-A relations. We applied this approach to the Clinical finding and Procedure subhierarchies …


Facilitating Clinical Information Extraction With Synthetic Data And Ontology Using Large Language Models, Yan Hu, Huan He, Qingyu Chen, Xiaoqian Jiang, Kirk Roberts, Hua Xu Jan 2024

Facilitating Clinical Information Extraction With Synthetic Data And Ontology Using Large Language Models, Yan Hu, Huan He, Qingyu Chen, Xiaoqian Jiang, Kirk Roberts, Hua Xu

Faculty, Staff and Student Publications

The rapid growth of unstructured clinical text in electronic health records necessitates robust information extraction systems, yet their development is hindered by the scarcity of high-quality annotated data. This study explores the potential of large language models to generate synthetic data for clinical named entity recognition and examines its impact on model performance. We propose a novel framework that integrates self-verified synthetic data generation with domain-specific semantic mapping using SNOMED-CT. By leveraging GPT-4o-mini for synthetic data creation and refining its quality through iterative verification and anomaly detection, we systematically evaluate the influence of synthetic data quality and quantity on fine-tuning …


Vegetarian Diet And Health Outcomes, Shabana Masood Jan 2024

Vegetarian Diet And Health Outcomes, Shabana Masood

CGU Theses & Dissertations

Introduction: Vegetarian diet is one of the most consistent diets which has shown long-term health benefits. According to a nationwide survey of adults 18+, 4% of Americans were vegetarians. The dissertation was divided into 3 separate studies and assessed the effect of vegetarian diet in the association between (Study1) childhood ADHD symptoms and young adult weight status; (Study 2) health behaviors and depression in young adults; (Study 3) comparison of weight perception and weight control strategies among vegetarians and non-vegetarians.

Methods: The National Longitudinal Study of Adolescent to Adult Health (Add Health) dataset is a national dataset spanning decades and …


Answering The “Now What?”: The Development Of A Transdisciplinary Breast Cancer Survivorship Nonprofit Organization, Vir-Iaesta Maniquiz Vergel De Dios Jan 2024

Answering The “Now What?”: The Development Of A Transdisciplinary Breast Cancer Survivorship Nonprofit Organization, Vir-Iaesta Maniquiz Vergel De Dios

CGU Theses & Dissertations

Although patients are living longer or are surviving breast cancer, the side effects of treatment still leave patients struggling with quality-of-life issues. The lack of whole-person care leaves patients unequipped after treatment is complete, searching for answers and a way to survive on their own. The unintended consequence becomes a dramatic shift from the weekly/daily medical appointments during active treatment to a silence that can be daunting for many to navigate. Living Your Truth Empowered, shortened to LYTE Foundation, is an antiauthoritarian minded and anti-hierarchal nonprofit created to address the needs of the growing breast cancer survivor population. LYTE is …


The Formation And Operationalization Of Charter(S) For The Lyte Foundation, Inc. (Living Your Truth Empowered), Through The Creation Of Policies, Roles, And Responsibilities Of Charter Leaders, Identification Of Resources, And Identification Of Community Needs, Charles Ngoc Tran Jan 2024

The Formation And Operationalization Of Charter(S) For The Lyte Foundation, Inc. (Living Your Truth Empowered), Through The Creation Of Policies, Roles, And Responsibilities Of Charter Leaders, Identification Of Resources, And Identification Of Community Needs, Charles Ngoc Tran

CGU Theses & Dissertations

This study aimed to develop policies and procedures needed for the operationalization of LYTE's charters. Employing a dual-methodology approach in document review and qualitative study, the study addressed two main objectives. The first is through document review and analysis of successful charters and nonprofit organizations in the US. With the insights gained from document analysis, drafts of policies required for LYTE’s charters operationalization were developed. The second is through interviews with organizational leaders and stakeholders such as breast cancer survivors and advocates. This provided perspectives and thematic insights crucial for tailoring policies specific to LYTE’s charters. The resulting deliverables include …


Xuebijing Improves Intestinal Microcirculation Dysfunction In Septic Rats By Regulating The Vegf-A/Pi3k/Akt Signaling Pathway, A-Ling Tang, Yan Li, Li-Chao Sun, Xiao-Yu Liu, Nan Gao, Sheng-Tao Yan, Guo-Qiang Zhang Jan 2024

Xuebijing Improves Intestinal Microcirculation Dysfunction In Septic Rats By Regulating The Vegf-A/Pi3k/Akt Signaling Pathway, A-Ling Tang, Yan Li, Li-Chao Sun, Xiao-Yu Liu, Nan Gao, Sheng-Tao Yan, Guo-Qiang Zhang

Faculty, Staff and Student Publications

BACKGROUND: This study aims to explore whether Xuebijing (XBJ) can improve intestinal microcirculation dysfunction in sepsis and its mechanism.

METHODS: A rat model of sepsis was established by cecal ligation and puncture (CLP). A total of 30 male SD rats were divided into four groups: sham group, CLP group, XBJ + axitinib group, and XBJ group. XBJ was intraperitoneally injected 2 h before CLP. Hemodynamic data (blood pressure and heart rate) were recorded. The intestinal microcirculation data of the rats were analyzed via microcirculation imaging. Enzyme-linked immunosorbent assay (ELISA) kits were used to detect the serum levels of interleukin-6 (IL-6), …


A Transformer-Based Deep Learning Approach For Fairly Predicting Post-Liver Transplant Risk Factors, Can Li, Xiaoqian Jiang, Kai Zhang Jan 2024

A Transformer-Based Deep Learning Approach For Fairly Predicting Post-Liver Transplant Risk Factors, Can Li, Xiaoqian Jiang, Kai Zhang

Faculty, Staff and Student Publications

Liver transplantation is a life-saving procedure for patients with end-stage liver disease. There are two main challenges in liver transplant: finding the best matching patient for a donor and ensuring transplant equity among different subpopulations. The current MELD scoring system evaluates a patient's mortality risk if not receiving an organ within 90 days. However, the donor-patient matching should also consider post-transplant risk factors, such as cardiovascular disease, chronic rejection, etc., which are all common complications after transplant. Accurate prediction of these risk scores remains a significant challenge. In this study, we used predictive models to solve the above challenges. Specifically, …