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Articles 62791 - 62820 of 325184

Full-Text Articles in Medicine and Health Sciences

Effects Of Comprehensive Sex Education On Unplanned Pregnancy Rates And Sti Occurrences Among Chinese American Adolescents, Onsheng Seto Jan 2024

Effects Of Comprehensive Sex Education On Unplanned Pregnancy Rates And Sti Occurrences Among Chinese American Adolescents, Onsheng Seto

Nursing | Senior Theses

Sexually transmitted diseases/infections (STIs) and unplanned pregnancies is a continuing health concern among adolescents. They are more likely to engage in risky behaviors that increase the likelihood for STIs and unplanned pregnancies which emphasizes the need for comprehensive sex education (CSE). This research proposal strives to determine if CSE is an effective tool in reducing cases of STIs and unplanned pregnancies, specifically in Chinese American adolescents. The literature review identified CSE successfully decreasing STIs and unplanned pregnancies in youths. However, limited research correlates the relationship between CSE and Chinese American adolescents. In addition, few studies take cultural influences into account …


Unveiling New Realities: An In-Depth Analysis Of Virtual Reality's Impact On Postoperative Adolescents, Julia Tolentino Jan 2024

Unveiling New Realities: An In-Depth Analysis Of Virtual Reality's Impact On Postoperative Adolescents, Julia Tolentino

Nursing | Senior Theses

The traditional approach to postoperative pain management heavily relies on opioids, but there’s been a surge in their misuse and adverse effects, leading to a significant public health concern. This has led healthcare providers to incorporate a multimodal approach aimed at reducing opioid dependence. This proposal introduces an immersive component, virtual reality (VR), not as a replacement for opioids but as a complementary tool offering distinct advantages for enhancing postoperative pain management. By immersing patients in a virtual environment, VR effectively distracts them from pain and discomfort, allowing for reduced opioid dosages and mitigating the risk of opioid misuse. Additionally, …


Nurse Suicide: Examining Depression And Anxiety In Critical Care Settings, Arianna Bernardine Barata Jan 2024

Nurse Suicide: Examining Depression And Anxiety In Critical Care Settings, Arianna Bernardine Barata

Nursing | Senior Theses

Nurses play a critical role in healthcare, yet the demanding work environment often exposes them to stressors, leading to the development of depression and anxiety. According to the National Library of Medicine (NLM) (2021), 50.8% of nurses have stress, 74% have anxiety, 70.8% have depression, and 79.1% have at least one of them. Burnout, understaffing, COVID fatigue, alarm fatigue, patient ratios, and disrupted sleep patterns are some of the stressors nurses contend with in every shift. While some nurses may cope and overcome these challenges, many face more severe issues, such as suicide. Nurse suicide is an issue that has …


Effects Of Menopause On Coronary Artery Disease, Angelica Gonzales Jan 2024

Effects Of Menopause On Coronary Artery Disease, Angelica Gonzales

Nursing | Senior Theses

Menopausal women, 40 to 60 years old, have an increased risk of developing coronary artery disease (CAD) when they experience hormonal changes. Which then can lead to unwanted cardiac events. Within the literature review of this paper, it was found that there are factors of menopause that may further increase the risk of coronary artery disease in menopausal women. Such factors include whether a woman underwent surgical or natural menopause and the timing when menopause began. Additionally, within the review, hormone replacement therapy (HRT) was explored to determine whether the possible intervention can decrease the progression and risk of developing …


Evaluating The Effectiveness Of Culture Based Nurse-Led Education For Postpartum Depression In Primiparous Asian-American Women, Colleen Peralta Jan 2024

Evaluating The Effectiveness Of Culture Based Nurse-Led Education For Postpartum Depression In Primiparous Asian-American Women, Colleen Peralta

Nursing | Senior Theses

The postpartum period is a critical period in regards to maternal health, marked by various physical, emotional, and psychological changes. Among the vulnerabilities that arise, postpartum depression (PPD) poses significant risks. More specifically, Asian-American mothers with postpartum depression face unique challenges, including the stigma surrounding mental health. As mental health stigma remains prevalent within the Asian-American community, it can make it challenging for mothers to seek out mental health care for postpartum depression. To investigate, primary research articles about the perceptions and experiences of PPD and the interventions used to improve PPD outcomes were examined. A plan for a future …


Unleashing Wellness: Exploring The Impact Of Pet Therapy On Anxiety Reduction, Quality Of Life, And Treatment Adherence In Pediatric Oncology Patients, Karina Brouwer Jan 2024

Unleashing Wellness: Exploring The Impact Of Pet Therapy On Anxiety Reduction, Quality Of Life, And Treatment Adherence In Pediatric Oncology Patients, Karina Brouwer

Nursing | Senior Theses

Pet therapy is a complementary intervention that involves the interaction between a person and animal, with the focus of improving psychological well-being within diverse populations. In particular, children with oncological disorders have increases in anxiety and stress levels, therefore it is imperative to study the impact of animal interventions within this population. This literature critique explores the impact of pet therapy interventions on anxiety, stress, and quality of life perceptions in pediatric oncology patients. This research proposal will investigate how animal therapy interactions within pediatric oncology patients influence their anxiety levels and perceptions of quality of life and how these …


The Impact Of Spanish Language Training For Labor And Delivery Nurses On Postpartum Depression Incidence Among Hispanic Women, Leilani Gutierrez Jan 2024

The Impact Of Spanish Language Training For Labor And Delivery Nurses On Postpartum Depression Incidence Among Hispanic Women, Leilani Gutierrez

Nursing | Senior Theses

Postpartum depression and anxiety are experienced by 70-80% of new mothers, and the likelihood is twice as high for Hispanic women compared to caucasian women. Supportive techniques to help monolingual mothers in labor are lacking. A translator's assistance on the hospital floor, such as a video call from an iPad, is often impersonal and lacks the supportive atmosphere that women preparing to give birth need. The primary objective of this study is to explore the potential benefits of providing Spanish-speaking courses to labor and delivery nurses, particularly in cultivating a nurturing and supportive atmosphere for Hispanic mothers during childbirth. By …


Male Caregiver Strain: The Mental Effects Of Being An Informal Caregiver For A Family Member With Dementia And Alzheimer's Disease, Alessandra M. Barillas, Elijah Rammel B. Borja Jan 2024

Male Caregiver Strain: The Mental Effects Of Being An Informal Caregiver For A Family Member With Dementia And Alzheimer's Disease, Alessandra M. Barillas, Elijah Rammel B. Borja

Nursing | Senior Theses

Background: Caregivers are vital in fulfilling patients' primary care needs, and families prefer them over sending their loved ones to skilled nursing facilities (SNFs). Alzheimer's Disease and Dementia are prevalent conditions necessitating continuous assistance due to memory and cognition impairments. As a result, support is essential for tasks like mobility, feeding, bathing, and perineal care, as well as emotional and physical challenges inherent in caregiving. Purpose: Upon diving into the mental health impacts of serving as an informal caregiver for individuals with Alzheimer's Disease and Dementia, a notable research gap becomes evident, especially concerning male caregivers. This lack of information …


How The Lockdown Of Covid-19 Influenced The Neurocognitive And Psychosocial Development Of Preschoolers, Kay Picson Jan 2024

How The Lockdown Of Covid-19 Influenced The Neurocognitive And Psychosocial Development Of Preschoolers, Kay Picson

Nursing | Senior Theses

COVID-19 caused schools to turn to online learning through platforms such as Zoom or Google Meet. The influence and effects caused by the transition to online lessons and quarantine were seen across all patient populations and demographics, but none more so than preschool children, who are regarded as one of the more vulnerable populations due to their susceptibility to change. This research aims to fill gaps in the existing literature by evaluating the similarities and differences of the neurocognitive and psychosocial development of preschoolers exposed to the pandemic and those who were not. This study involves a comparative cohort approach …


Reducing Emergency Department Visits For Children With Autism Spectrum Disorder: Nurse-Led Home Interventions, Teri Nguyen Jan 2024

Reducing Emergency Department Visits For Children With Autism Spectrum Disorder: Nurse-Led Home Interventions, Teri Nguyen

Nursing | Senior Theses

In the realm of pediatric healthcare, children diagnosed with Autism Spectrum Disorder (ASD) face unique challenges alongside their caregivers. Caregivers face challenges in accessing appropriate support and resources to effectively address the needs of children with ASD. Children with ASD struggle with sensory sensitivities, impaired safety awareness, and difficulties perceiving potential dangers which put them at greater risk for injuries. As a result, children with autism have higher rates of emergency department visits compared to their neurotypical peers. This research aims to assess the effectiveness of nurse-led home injury prevention and education in reducing emergency department visits for children with …


Medical Cannabis In Pediatric Chronic Pain And Diseases, Marissa Colombo Jan 2024

Medical Cannabis In Pediatric Chronic Pain And Diseases, Marissa Colombo

Nursing | Senior Theses

Background: Pediatric chronic pain has seen a disturbing rise which ends up affecting the child’s routine and impacting their family’s lives. Medical cannabis has Food and Drug Administration-approved derivatives, yet the studies that focus on medical cannabis do not discuss targeting pain in pediatric patients. Children who experience chronic diseases and treatment-resistant pain are not normally offered medical cannabis as a treatment option which needs to change. Objective: The purpose of this paper is to explore the impact of medical cannabis within the pediatric population. If children experience pain that is similar to adults, withholding techniques that can help alleviate …


Telehealth: A Rising Intervention For Latina Mothers Experiencing Prenatal And Postpartum Depression, Britney Gutierrez Jan 2024

Telehealth: A Rising Intervention For Latina Mothers Experiencing Prenatal And Postpartum Depression, Britney Gutierrez

Nursing | Senior Theses

Background: Postpartum depression (PPD) is high among Latina women but often goes unrecognized and untreated. Recognition and management of PPD in this population is crucial as PPD contributes to negative health effects on the mother and infant. Purpose: This research aims to look into telehealth to improve screening methods and treatment for Latina mothers through a Spanish mobile health application that will provide screening and education on PPD. Method: This mixed-method quality improvement study will include 300 participants from an OB-GYN and Pediatrics community clinic, > 18 years old, of Hispanic/Latino ethnicity, Spanish speaking, currently pregnant, or had a child within …


Optimizing Ventilator-Associated Pneumonia Prevention And Education: In Adult Icu Settings, Danielle Gonzalez Jan 2024

Optimizing Ventilator-Associated Pneumonia Prevention And Education: In Adult Icu Settings, Danielle Gonzalez

Nursing | Senior Theses

Background: Ventilator associated pneumonia (VAP) in adult intensive care patient units (ICU) is one of the most common and deadly nosocomial infections today. Studies have identified a gap in intensive care nurse ventilator education and compliance with hospital protocols. Overall increasing the rates of VAP and morbidity. Hospitals worldwide have shown a decrease in VAP rates after inheriting "VAP-bundles''. This includes nurse specific interventions and assessments as a preventative measure. However, studies failed to demonstrate which bundle interventions directly correspond to the prevention of VAP. Purpose: Address all components of education, a nurse’s ability to properly identify and understand the …


Developmental Effects Of Child Abuse: The Relevance Of Timing, Laura Luz Alvarez Pineda, Karla Susana Saldaña Jan 2024

Developmental Effects Of Child Abuse: The Relevance Of Timing, Laura Luz Alvarez Pineda, Karla Susana Saldaña

Nursing | Senior Theses

Background: Early physical, sexual, and emotional child abuse has been associated with long-life cognitive, emotional, and physical health repercussions. Purpose: The current paper, in addition to a literature review, proposes a research design to examine the emotional outcomes of physical, emotional, and sexual child abuse on Hispanics when a psychosocial therapy program is implemented. Methods: Participants will be recruited from children’s hospitals, daycares, and preschools around the Bay Area. Parental-informed consent will be obtained prior to participation. This longitudinal quantitative quasi-experimental study will be comprised of three phases to measure posttraumatic stress and depression symptoms, and suicidal ideation. Results: Multivariate …


Enhancing Mental Health Support And Reducing Burnout In Nursing: A Holistic Approach, Alexa Miller, Andrea Quintela Jan 2024

Enhancing Mental Health Support And Reducing Burnout In Nursing: A Holistic Approach, Alexa Miller, Andrea Quintela

Nursing | Senior Theses

Urgent action is needed to strengthen mental health support for nurses experiencing burnout. This thesis examines the stigma surrounding burnout in the nursing community and implements holistic approaches to alleviate burnout of those affected. Integrating mental health awareness, mindfulness-based interventions, personal self-care, and supportive hospital practice can decrease nurse burnout. By first coming to terms with nurse turnover and further prioritizing nurses' physiological, emotional, and social welfare, leadership and organization can implement holistic strategies to address these diverse challenges nurses face. Through a deep dive into existing literature, relevant studies, and a blend of critical findings, this thesis emphasizes the …


Advancing School Nursing Practice: A Novel Approach To Screening For Gastrointestinal Disorders In Children, Ashley Bunting, Isabella Cavlan Jan 2024

Advancing School Nursing Practice: A Novel Approach To Screening For Gastrointestinal Disorders In Children, Ashley Bunting, Isabella Cavlan

Nursing | Senior Theses

Background: Currently, mandated health screenings in California schools are limited to vision, hearing, and scoliosis; this leaves several other body systems unmonitored during the crucial years of childhood development. One such system is the gastrointestinal (GI) system, which plays a vital role in the normal growth, nutrition status, development, and overall health of children. Objective: By developing and implementing a GI-specific screening tool in the outpatient school setting, this research aims to increase the detection of GI disorders in children. Not only that, but school nurses can use this novel screening tool to promote early diagnosis, intervention, and …


Public Health Implications Of Social Media On Adolescent Health Behaviors: Upstream Approaches To Prevention Strategies, Joseph Donnelly, Elena Saldutti Jan 2024

Public Health Implications Of Social Media On Adolescent Health Behaviors: Upstream Approaches To Prevention Strategies, Joseph Donnelly, Elena Saldutti

Department of Public Health Scholarship and Creative Works

This commentary provides a comprehensive overview of the influence of social media on the health and well-being of adolescents, focusing on emotional/mental health, self-esteem, alcohol and drug use, peer pressure, and both negative and positive influences. It highlights concerns about the potential negative impact of social media, including increased levels of anxiety, depression, and loneliness, as well as the impact on self- esteem through seeking validation and unrealistic comparisons. Furthermore, it discusses how social media exposes adolescents to content promoting alcohol and drug use and amplifies peer pressure, leading to potential substance abuse and negative decision-making. Despite these drawbacks, the …


Robotic-Assistance In Total Hip Arthroplasty Is Associated With Decreased Dislocation Rates, Gabrielle N. Swartz, Sandeep S. Bains, Jeremy A. Dubin, Reza Katanbaf, Hunter Hayes, James Nace, Michael A. Mont, Ronald E. Delanois Jan 2024

Robotic-Assistance In Total Hip Arthroplasty Is Associated With Decreased Dislocation Rates, Gabrielle N. Swartz, Sandeep S. Bains, Jeremy A. Dubin, Reza Katanbaf, Hunter Hayes, James Nace, Michael A. Mont, Ronald E. Delanois

Orthopedic Surgery Resident Research

Background

As the use of robotics in total hip arthroplasty (THA) continues to gain popularity, differences in clinical outcomes when compared to manual techniques have remained unclear. This study aimed to compare postoperative complications between patients undergoing robotic-assisted techniques and manual THA for primary osteoarthritis at 90 days, 1 year, and 2 years.

Methods

Using an all-payer national database, we identified 405,048 patients who underwent either robotic-assisted or manual THA for primary osteoarthritis. A propensity match was performed for age, sex, a comorbidity index, chronic kidney disease, obesity, and diabetes, resulting in 7652 patients in each cohort. We assessed postoperative …


Utilizing A Structured Music Therapy Program For Adolescents With Anxiety And Depression, Amy Haagen Jan 2024

Utilizing A Structured Music Therapy Program For Adolescents With Anxiety And Depression, Amy Haagen

West Chester University Doctoral Projects

Anxiety and depression are two of the most common mental health issues that affect children and adolescents. It has been noted that twenty percent of adolescents will have a depressive episode or be affected by anxiety by the time they are 18 years old. Mental health issues affecting children and adolescents majorly impact all aspects of their lives, most notably academic success, behavior, growth, and development (Porter et al., 2017). Current treatments for mental disorders, including depression and anxiety, include pharmacological and psychotherapeutic treatments. In the adolescent population, there are conflicting opinions on the use of antidepressants due to risks …


Concepts In Animal Parasitology, Chapter 39: Haplosplanchnata Olson Et Al., 2003 (Suborder): Two Hosts With Half The Guts [Platyhelminthes, Trematoda, Digenea, Plagiorchiida], Daniel C. Huston Jan 2024

Concepts In Animal Parasitology, Chapter 39: Haplosplanchnata Olson Et Al., 2003 (Suborder): Two Hosts With Half The Guts [Platyhelminthes, Trematoda, Digenea, Plagiorchiida], Daniel C. Huston

Concepts in Animal Parasitology

An overview of the suborder Haplosplanchnata Olson et al., 2003, a small, but distinct lineage within the Plagiorchiida. Includes a discussion of the methods of identification, general morphological characteristics, taxonomy, and life cycles.

Chapter 39 in Concepts in Animal Parasitology, by Daniel C. Huston. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap039


Concepts In Animal Parasitology, Chapter 47: Summary Of The Digenea (Subclass): Insights And Lessons From A Prominent Parasitologist [Platyhelminthes, Trematoda, Digenea], Robin M. Overstreet Jan 2024

Concepts In Animal Parasitology, Chapter 47: Summary Of The Digenea (Subclass): Insights And Lessons From A Prominent Parasitologist [Platyhelminthes, Trematoda, Digenea], Robin M. Overstreet

Concepts in Animal Parasitology

An overview of the digenean trematodes (subclass Digenea) including insights and lessons from a prominent parasitologist, Robin M. Overstreet. Includes discussion of general morphology, biology, preparation methods, phylogeny, classification, life cycles, host-digenean relationships, effects on host behavior, hyperparasitism, ecology, digeneans as indicators, and literature on the digeneans.

Chapter 47 in Concepts in Animal Parasitology, by Robin M. Overstreet. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap047


Concepts In Animal Parasitology, Chapter 60: Monogenea Van Beneden, 1858 (Class) [Platyhelminthes], Griselda Pulido-Flores Jan 2024

Concepts In Animal Parasitology, Chapter 60: Monogenea Van Beneden, 1858 (Class) [Platyhelminthes], Griselda Pulido-Flores

Concepts in Animal Parasitology

An overview of the class Monogenea van Beneden, 1858, mainly ectoparasites of the skin, fins, gills, and urinary bladder of fishes, amphibians, and some reptiles. Includes discussion of their classification (both historical and current), general morphology, life cycles, and taxonomy.

Chapter 60 in Concepts in Animal Parasitology, by Griselda Pulido-Flores. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap060


Concepts In Animal Parasitology, Chapter 64: Phthiraptera (Order): Lice [Arthropoda], Lajos Rózsa, Haylee J. Weaver Jan 2024

Concepts In Animal Parasitology, Chapter 64: Phthiraptera (Order): Lice [Arthropoda], Lajos Rózsa, Haylee J. Weaver

Concepts in Animal Parasitology

An overview of lice, order Phthiraptera, including discussion of their general morphology, feeding, host range, host distribution, life cycle, macroecology, transmission, effects on hosts and role as vectors, host defenses, conservation, evolutionary origins, phylogeny, lice nuclear genome, taxonomy, and medical implications including their control.

Chapter 64 in Concepts in Animal Parasitology, by Lajos Rózsa and Haylee J. Weaver. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap064


Senior Mental Health Clinicians’ Understanding Of Their Self-Efficacy While Providing Services At Community-Based Agencies, Rukiya Symister Jan 2024

Senior Mental Health Clinicians’ Understanding Of Their Self-Efficacy While Providing Services At Community-Based Agencies, Rukiya Symister

Walden Dissertations and Doctoral Studies

Many mental health clinicians strive to provide their clients with rehabilitative and psychotherapy services resulting in a client gaining stable income and housing. However, the role of a senior mental health clinician (SMHC) is not without its challenges of trying to balance their well-being while dealing with increased coworker turnover, demanding caseloads, and limited access to community resources to provide clients with getting their lives back on track, thereby impacting clinicians’ understanding of their self-efficacy. Much of the research on self-efficacy has focused on mental health clients, mental health graduate students, and mental health trainees, often leaving out the lived …


Enhancing 21 U.S.C. §§ 355, 356, And 360 To Encompass Artificial Intelligence-Based Drug Design And Manufacturing Methods, Aj Tsang Jan 2024

Enhancing 21 U.S.C. §§ 355, 356, And 360 To Encompass Artificial Intelligence-Based Drug Design And Manufacturing Methods, Aj Tsang

Michigan Technology Law Review

Despite newfound attention to how artificial intelligence (AI) may accelerate pharmaceutical development, federal regulators may find that current statutes are ambiguous or silent about their applicability to AI-based drug design and manufacturing methods. This poses a serious problem in the era of Loper Bright and the Major Questions Doctrine. As federal agencies struggle to adjust to courts’ growing demand for Congress to craft clear, explicit, and express delegations of authority, this note develops a statutory framework in which the Food and Drug Administration (FDA) would have more flexibility to regulate the use of AI in advanced drug manufacturing. Guided by …


Iuphar-Review: The Integration Of Classic Psychedelics Into Current Substance Use Disorder Treatment Models, David Yaden, Andrea Berghella, Peter Hendricks, Mary Yaden, Michael Levine, Julia Rohde, Sandeep Nayak, Matthew Johnson, Albert Garcia-Romeu Jan 2024

Iuphar-Review: The Integration Of Classic Psychedelics Into Current Substance Use Disorder Treatment Models, David Yaden, Andrea Berghella, Peter Hendricks, Mary Yaden, Michael Levine, Julia Rohde, Sandeep Nayak, Matthew Johnson, Albert Garcia-Romeu

SKMC Student Presentations and Publications

Substance use disorders (SUDs) have an enormous impact on public health. With classic psychedelic-assisted therapies showing initial promise in treating multiple SUDs, it is possible that these treatments will become legally available options for patients with SUDs in the future. This article highlights how classic psychedelic-assisted therapies might be integrated into current clinical practice. We first describe contemporary evidence-based treatments for SUDs and highlight how classic psychedelic-assisted therapies might fit within each treatment. We suggest that classic psychedelic-assisted therapies can be integrated into most mainstream evidence-based SUD treatments that are currently used in clinical settings, indicating broad compatibility of classic …


The Effect Of Speed Sintering On The Optical Properties And Microstructure Of Multi-Layered Cubic Zirconia, Ahmed Sabet Jan 2024

The Effect Of Speed Sintering On The Optical Properties And Microstructure Of Multi-Layered Cubic Zirconia, Ahmed Sabet

Dentistry

Purpose: Speed sintering was introduced to fabricate time-efficient chairside restorations, however, its influence on the microstructure and optical properties of zirconia is still unclear. This study investigated the influence of speed sintering on the microstructure and optical properties of ultra-translucent multi-layered cubic zirconia. Materials and methods: Ultra-translucent cubic zirconia (Katana™ UTML; Kuraray Noritake Dental Inc., Aichi, Japan) was cut into a total of 80 specimens, twenty within each layer of the blank. The specimens were divided into 2 groups: speed and conventional sintering. The translucency parameter, opalescence, chromaticity, and color difference were recorded using a spectrophotometer. Scanning electron microscope images …


Dysplasia In Oral Lichen Planus In A Sample Of Egyptians Attending 2 Tertiary Care Centers In Cairo, Dalia Ghalwash, Ayman El-Gawish Jan 2024

Dysplasia In Oral Lichen Planus In A Sample Of Egyptians Attending 2 Tertiary Care Centers In Cairo, Dalia Ghalwash, Ayman El-Gawish

Dentistry

The present retrospective study aimed to evaluate dysplastic changes in oral lichen planus (OLP) lesions and related risk factors in a sample of Egyptians. The records of patients with histological diagnosis of OLP, who attended the Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, and Faculty of Dentistry, the British University in Egypt, in the period from 2020 to 2023 were used. The frequency of dysplasia was 10.19% and was statistically not associated with age, gender or smoking. Our results showed that the erosive type registered the highest rate (p<0.001), followed by atrophic, whereas papular type did not show dysplasia. Also, the most common site for dysplasia was the buccal mucosa and tongue (p<0.001 and p=0.001, respectively), then gingiva, lips, and floor of the mouth. Given the importance of OLP, among the Egyptian population seeking care in our clinics, more research should be conducted to create a database of statistical information.

https://doi.org/10.1111/odi.151


In Vivo Scanning Laser Fundus And High-Resolution Oct Imaging Of Retinal Ganglion Cell Injury In A Non-Human Primate Model With An Activatable Fluorescent-Labeled Tat Peptide Probe, Xudong Qiu, Seth T Gammon, Carol Rasmussen, Federica Pisaneschi, Charlene B Y Kim, James Ver Hoeve, Steven W Millward, Edward M Barnett, T Michael Nork, Paul L Kaufman, David Piwnica-Worms Jan 2024

In Vivo Scanning Laser Fundus And High-Resolution Oct Imaging Of Retinal Ganglion Cell Injury In A Non-Human Primate Model With An Activatable Fluorescent-Labeled Tat Peptide Probe, Xudong Qiu, Seth T Gammon, Carol Rasmussen, Federica Pisaneschi, Charlene B Y Kim, James Ver Hoeve, Steven W Millward, Edward M Barnett, T Michael Nork, Paul L Kaufman, David Piwnica-Worms

Faculty, Staff and Student Publications

The optical imaging agent TcapQ488 has enabled imaging of retinal ganglion cell (RGC) injury in vivo in rodents and has potential as an effective diagnostic probe for early detection and intervention monitoring in glaucoma patients. In the present study, we investigated TcapQ488 in non-human primates (NHPs) to identify labeling efficacy and early signals of injured RGC, to determine species-dependent changes in RGC probe uptake and clearance, and to determine dose-limiting toxicities. Doses of 3, 6, and 12 nmol of TcapQ488 were delivered intravitreally to normal healthy NHP eyes and eyes that had undergone hemiretinal endodiathermy axotomy (HEA) in the inferior …


Dynamics Of Cell Membrane Lesions And Adaptive Conductance Under The Electrical Stress, Mantas Silkunas, Olga N. Pakhomova, Giedre Silkuniene, Andrei G. Pakhomov Jan 2024

Dynamics Of Cell Membrane Lesions And Adaptive Conductance Under The Electrical Stress, Mantas Silkunas, Olga N. Pakhomova, Giedre Silkuniene, Andrei G. Pakhomov

Bioelectrics Publications

Exceeding physiological limits of the cell membrane potential compromises structural integrity, enabling the passage of normally impermeant solutes and disrupting cell function. Electropermeabilization has been studied extensively at the cellular scale, but not at the individual membrane lesion level. We employed fast total internal reflection fluorescence (TIRF) imaging of Ca(2+) entry transients to discern individual lesions in a hyperpolarized cell membrane and characterize their focality, thresholds, electrical conductance, and the lifecycle. A diffuse and momentary membrane permeabilization without a distinct pore formation was observed already at a -100 mV threshold. Polarizing down to -200 mV created focal pores with a …