Medicine and Health Sciences Commons^™

Development Of Research Direction At The Hospital General De México In The Last Two Decades, Juan C. Lopez-Alvarenga, José D. Carrillo-Ruiz, Galileo Escobedo, América Guadalupe Arroyo Valerio, Miguel Fonseca-Sanchez, Gustavo Acosta-Altamirano

School of Medicine Publications

No abstract provided.

Optimizing Costs & Efficiency With Heartcode Complete: A Quality Improvement Project, Jessica Bryant

Doctor of Nursing Practice Final Project Abstract

PURPOSE

This quality improvement project aimed to implement HeartCode Complete (HCC), a simulation-based BLS training platform, at a 154-bed community hospital. The goal was to replace instructor-led BLS training, improve training efficiency, reduce costs, increase certification compliance, and enhance staff satisfaction.

BACKGROUND

Maintaining competency in CPR is a regulatory requirement for healthcare providers. Traditional instructor-led BLS training requires scheduled classes, instructor availability, and staff time away from clinical duties, contributing to certification delays and operational inefficiencies. Simulation-based training platforms offer self-directed learning with real-time feedback.

METHODOLOGY

This quality improvement project used Lean Six Sigma principles and Plan-Do-Study-Act cycles to guide …

An Evidence-Based Approach To Boosting Recovery In Endurance Runners, Sayla F. Rios

Doctor of Nursing Practice Final Project Abstract

Purpose

The purpose of this quality improvement project was to implement evidence-based recovery strategies among endurance runners. The project aims to decrease injury prevalence, improve recovery behaviors, and reduce perceived muscle soreness.

Background

Running-related injuries are common among endurance runners and are often associated with inadequate recovery. Evidence suggests that the use of recovery strategies may support muscle repair and reduce injury risk.

Methodology

This project used the Plan–Do–Study–Act framework to guide the implementation of strategies. 24 endurance runners participated in the project. Interventions included education and the implementation of recovery strategies, such as adequate protein intake, sleep optimization, self-myofascial …

Identifying Delays Impacting Maternal And Perinatal Deaths Using A Facility-Based Death Audit Review System Integrated With Community Engagement: A Mixed Methods Study, Zahid Memon, Wardah Ahmed, Shah Muhammad, Sajid Soofi, Shanti Chouhan, Arjumad Rizvi, Paul Barach, Zulfiqar A. Bhutta

College of Population Health Faculty Papers

BACKGROUND: Pakistan's persistently high maternal (178 per 100 000 livebirths) and neonatal (41 per 1000 livebirths) mortality ratios are compounded by lack of reliable data on the root causes and preventable risk factors, which hinders their effective use in improving care and progress toward safe, high-quality services. We sought to identify system delays impacting maternal and perinatal deaths using a facility-based death audit review system integrated with community engagement for implementing actionable solutions.

METHODS: We used a mixed methods, concurrent parallel study design at three secondary level healthcare facilities in District Matiari, Sindh, Pakistan. We reviewed 319 cases that included …

Mississippi Coastal Bacterial Community Response To Lowered Salinty, Jackson C. Sues

Honors Theses

Microbial communities are essential to the function of coastal ecosystems; however, few studies have examined their response to short-term reductions in salinity. This study used a microcosm approach to examine how decreased salinity over five days affected seawater bacterial community composition, diversity, and richness. Microcosms were assigned to three treatments: unmanipulated seawater (control) collected from the Mississippi coast, seawater amended with natural freshwater, and seawater amended with sterilized freshwater. Length of time bacteria spent in the microcosms was found to have the strongest effect on bacterial community composition, while salinity effects were weaker but still statistically significant. All treatments shifted …

How Pollinator Populations Can Impact Chronic Disease Risk, Kylee Cubbison

Honors Projects

This project investigates how pollinator populations can impact chronic disease risk. Pollinator populations are declining, which can have serious implications for human health. Declining pollinator populations can limit healthy food production and affordability. Poor nutrition is a major risk factor for most chronic diseases. Less healthy food available for people to consume can negatively impact diets and increase the risk of developing chronic diseases. This project aims to address a potential gap in research existing on this specific topic regarding pollinator populations and human chronic disease risk. A brochure targeted towards educating the general public on this topic was created …

Nurse Education On Nonpharmacological Management Of Knee Osteoarthritis, Toyin Mary Ajayi

Walden Dissertations and Doctoral Studies

The Doctor of Nursing Practice (DNP) project aims to fill the gaps in the management of knee osteoarthritis (OA) in adults aged 40 to 75 years in a primary care practice. Knee OA is a common chronic disease that significantly impacts pain, mobility, and quality of life. Although there is empirical evidence that nonpharmacological interventions, including exercise, weight control, and self-management education, are effective, these methods are not consistently used in clinical practice, and pharmacologic treatment continues to be used. The project was designed to inform healthcare personnel about evidence-based nonpharmacological strategies to improve patient outcomes and reduce reliance on …

Hospital-Acquired Pressure Injury Prevention Using A Care Bundle In A Neuroscience Intensive Care Unit, Sarah Dolick

Doctor of Nursing Practice Final Project Abstract

Purpose: The purpose of this quality improvement DNP project was to implement a preventative care bundle to reduce the number of hospital-acquired pressure injuries.Compliance with bundle elements was monitored through weekly bedside audits. HAPI data were collected for 12 weeks pre-intervention and 12 weeks post-intervention to evaluate outcomes. The project utilized Plan-Do-Study-Act (PDSA) cycles to refine implementation and address barriers in real time.

Background: The project was implemented in a 32-bed neuroscience intensive care unit in an academic center in the Texas Medical Center.

Results: After implementation of the care bundle, average HAPIs decreased from 4.6 per survey (pre-intervention) to …

Staff Education On Early Sepsis Recognition For Medical-Surgical Nurses In The Acute Care Setting, Nadine Nzenga Udom

Walden Dissertations and Doctoral Studies

In this staff education project, I targeted early sepsis recognition and response among medical-surgical nurses. The practice gap at the site was nurses’ limited knowledge of sepsis indicators and screening tools, which contributed to delayed escalation of care. The practice-focused question guiding the project was “Does educating medical-surgical nurses on early sepsis recognition and response improve knowledge of early sepsis recognition and response?” I applied the analysis, design, development, implementation, and evaluation (ADDIE) and Johns Hopkins Evidence-Based Practice (JHEBP) models to design a structured sepsis education program for nursing staff. I searched for peer-reviewed literature via databases accessed through the …

Inhibition Of Cyclophilin D Rescues Cardiac Function And Bioenergetic Defects Caused By Neonatal Hypoxia, Jonathan R. Burris, Gisela Beutner, Min Yee, Bartholomew V. Simon, Michael F. Swartz, Kathryn B. Boudreau, Ethan D. Cohen, Chaitanya A. Kulkarni, Prottoy Hasan, Hongyue Wang, Karen L. De Mesy Bentley, György Hajnóczky, George M. Alfieris, Eric M. Small, Paul S. Brookes, Michael A. O'Reilly, George A. Porter

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Increased oxygen levels at birth regulate myocyte bioenergetic and structural maturation controlled by mitochondrial cyclophilin D (CypD). We evaluated mechanisms of neonatal hypoxic cardiac dysfunction by exposing neonatal mice to 12% oxygen and studied cardiac bioenergetics, myocyte maturation, and function. Hypoxia decreased the activity/assembly of electron transport chain complex I, uncoupled oxidative phosphorylation, increased proliferation, decreased differentiation, increased ventricular mass, and decreased cardiac function. CypD inhibition rescued most hypoxia-mediated effects and increased cardiac function. In conclusion, neonatal hypoxia alters cardiac bioenergetics, myocyte maturation, and cardiac function through CypD-dependent pathways, providing potential therapeutic targets for neonatal cardiac dysfunction.

Program And Proceedings, The Nebraska Academy Of Sciences 1880–2026: 146th Anniversary Year, One Hundred-Thirty-Sixth Annual Meeting

Nebraska Academy of Sciences: Programs and Proceedings

Program and abstracts of the proceedings for the Nebraska Academy of Sciences 136th annual meeting, 2025

Sessions

Aeronautics and Space Science

Anthropology

Biological and Medical Sciences

Earth Sciences

Ecology, Sustainability, and Environmental Science

Physics and Engineering

General Poster Session

2026 Maiben Lecture: Shifting Extremes: Understanding Nebraska’s Changing Climate and Preparing for What Lies Ahead, Deborah Bathke

2026 Friends of Science Awards: Julie Shaffer and Irina Filina

2026 C. Bertrand and Marian Othmer Schultz Colleaguate Schoalrship Award: Piper Ryschon and Bryce Reeson

In Memoriam: Paul Royster

Speed Of Intravenous Fluid On Glycocalyx Integrity And Central Blood Volume In A Porcine Septic Shock Model, Yosef Levenbrown, Md Jobayer Hossain, Paul T. Fawcett, Marjorie Postell, Anne M. Hesek, Lynell S. Jones, James P. Keith, Thomas H. Shaffer

Department of Pediatrics Faculty Papers

BACKGROUND: It is unclear whether the rate of intravenous fluid (IVF) administration in sepsis influences glycocalyx breakdown. This study aimed to measure the effect of rapid versus slow fluid bolus in a septic pig model on the integrity of the glycocalyx by measuring the serum levels of heparan sulfate and syndecan-1, breakdown products of the glycocalyx. Because endothelial glycocalyx is composed of apical cell membrane-bound proteoglycans such as syndecan-1, covalently bound with long linear glycosaminoglycans such as heparan sulfate, shedding of these different glycocalyx components is closely related. Additionally, we measured central blood volume (blood volume in the heart and …

Engineering Function In Lung Biology: Integrating Imaging, Regenerative Constructs, And Functional Biodesign, Rene A Girard, Jamie Tran, Yuqing Cai, Mary C Farach-Carson, Hadi T Nia, Allison M Greaney, Laura E Niklason, Killian Hurley, Elvin Blanco, Sinem Koc-Günel, Harry Karmouty-Quintana

Faculty, Staff and Student Publications

The lung is a uniquely demanding target for regeneration because function depends on the coordinated integration of cellular diversity, three-dimensional architecture, cyclic mechanical forces, vascular perfusion, immune surveillance, and extracellular matrix remodeling. While single-cell and spatial profiling, lineage tracing, and iPSC-derived models have transformed our understanding of lung cell states and developmental potential, these descriptive approaches have also highlighted a central bottleneck: the field still lacks broadly adopted platforms to test whether engineered tissues and regenerative interventions restore function under physiologic load. In this review, we focus on emerging technologies that enable functional biodesign in lung biology by coupling engineered …

A Risk-Based Model For Unplanned Cesarean Delivery Following Induction Of Labor In Term Hypertensive Nulliparas., Avihu Krieger, Michal Axelrod, Baha Sibai, Shalom Mazaki-Tovi, Michal Fishel Bartal

Faculty, Staff and Student Publications

Purpose: To develop a practical risk-stratification framework for unplanned cesarean delivery (CD) among term nulliparous individuals with hypertensive disorders of pregnancy (HDP) undergoing induction of labor (IOL).

Methods: This was a retrospective cohort study at a single tertiary care center (January 2010-March 2025) of nulliparous individuals with singleton gestations diagnosed with HDP undergoing IOL at ≥ 37 + 0 weeks. We excluded multiple gestations, major fetal anomalies, planned CD, or intrauterine fetal death. We included demographic and pregnancy characteristics available prior to induction and evaluated association with unplanned CD. Stepwise backward logistic regression was used to build a model for …

Practical Exploration Of The Role Of Occupational Therapy In A Nature-Based School Setting, Emma Campbell

Capstone Projects

School-based occupational therapy (OT) plays a critical role in supporting children’s participation, development, and engagement in educational environments. However, non-traditional school settings often lack therapeutic supports, such as OT services. The purpose of this doctoral capstone experience (DCE) is to explore and expand the role of occupational therapy within a non-traditional academic setting, specifically a nature-based preschool program. Sunflower Farm’s preschool program provides a unique learning environment that supports children’s development through farm-based learning. While this setting offers rich opportunities for exploration and growth, additional supports are needed to facilitate students’ sensory processing, self-regulation, and participation.

The objectives of this …

Sexuality And Intimacy: Education On Ot Approach, Abby Stritzinger

Capstone Projects

Providing proper education on sexuality and intimacy is important for increasing comfort when addressing sex and intimacy with individuals in the professional field.  “Sexual health requires a positive and respectful approach to sexuality and sexual relationships, as well as the possibility of having pleasurable and safe sexual experiences, free of coercion, discrimination and violence. For sexual health to be attained and maintained, the sexual rights of all persons must be respected, protected and fulfilled” (WHO, 2006a). Creating occupational therapists (OTs) that are comfortable addressing this topic is extremely important for the OT profession to continue to maintain its holistic, client-centered …

Expanding Access To Equine-Assisted Occupational Therapy: Integrating Clinical Application And Program Development, Deanna Rietveld

Capstone Projects

This capstone project explored the role of hippotherapy in occupational therapy through enhanced clinical practice skills as well as supporting program development through community education and funding accumulation for the capstone site organization. Guided by a needs assessment drawn from literature, site mentor input, and other local organizations providing similar services, it was determined that occupational therapy using equine movement provides more impactful results while simultaneously addressing deficits in a variety of areas, but lack of financial resources, community participation, and therapy scholarships threaten the opportunity to expand programs and provide access to individuals who would benefit from services. In …

Promoting Maternal Well-Being: Occupational Therapy In Pregnancy And Postpartum, Nora Udrys

Capstone Projects

Navigating pregnancy and the postpartum period can be a complex experience for women. There is a lack of diverse information, accessible resources, and support during this phase of life. Hormonal levels fluctuate not only during pregnancy but after giving birth as well, contributing to significant physical, emotional, and cognitive changes. Some of these changes may create barriers to meaningful participation in daily occupations, contributing to feelings of isolation, mood disruptions, and decreased overall well-being. Occupational therapy has a unique role in supporting women through pregnancy and postpartum by helping them navigate these transitions through a holistic, client-centered lens. The purpose …

Development Of Purposeful Movement Breaks And Sensory Pathways To Enhance Student Engagement And Participation, Ashlyn Houck

Capstone Projects

Children in school settings frequently spend extended periods seated in classrooms, which can make it difficult to meet their sensory and movement needs throughout the school day. When these needs are unmet, students may demonstrate behaviors that disrupt learning and limit participation in classroom activities. This capstone project addressed the need for sensory and movement opportunities within the school environment. Objectives included establishing a baseline of teacher knowledge related to the sensory systems, implementing movement breaks within daily classroom routines, and introducing sensory opportunities in hallways to support smoother transitions. The project was implemented with second- and third-grade classrooms. Outcomes …

Expanding Nbcot® Exam Readiness Resources In An Entry-Level Otd Program, Thahiyatul Sarah

Capstone Projects

The National Board for Certification in Occupational Therapy (NBCOT®) exam is a critical requirement for entry-level occupational therapy (OT) practice in the United States; however, many students face challenges in effectively preparing for its clinical reasoning demands. This literature review examines existing research on NBCOT® exam preparation strategies to inform the development of a comprehensive exam content guide and resources tailored for OT graduate students. Existing barriers, including gaps in curriculum alignment, limited access to effective study tools, and high levels of student stress, highlight the need for more structured and accessible preparation methods. By examining key themes such as …

Exploring Lived Experiences And Perceived Quality Of Life In Individuals With Parkinson’S Disease Engaging In Rock Steady Boxing: A Qualitative Study, Emma Norman

Capstone Projects

It is well established that exercise provides numerous benefits to the general population, including improved physical functioning, fall prevention, and better sleep (National Institute on Aging, 2025). For individuals living with Parkinson’s Disease, the benefits of exercise are especially meaningful as exercise plays a key role in managing symptoms. Regular exercise plays a critical role in managing both motor and non-motor symptoms of Parkinson’s Disease, contributing to improved quality of life and independence (Ellis & Rochester, 2018). A group fitness program for individuals with Parkinson’s Disease, called Rock Steady Boxing, has demonstrated positive quantitative outcomes, including improved balance, strength, and …

Modeling Early Human Heart Development Using An Ipsc-Based 3d Bioprinted Model Of Embryonic Heart Tube, Linqi Jin, Christian Park, Sunder Neelakantan, Shweta Karnik, Arnab Dey, Sarah Fineman, Roshni Nandwani, Carmen J Gil, Boeun Hwang, Melissa A Cadena, Vani Sridhar, Jing Wang, Yuxiao Wu, Connor J Evans, Lan Li, Sarah Rezapourdamanab, Mehdi Salar Amoli, Martin L Tomov, Ryan K Roeder, Reza Avazmohammadi, Lakshmi Prasad Dasi, Hanjoong Jo, Eric Weeks, Holly D Bauser-Heaton, Sean M Wu, Vahid Serpooshan

Faculty, Staff and Student Publications

Human heart development depends on tightly coordinated genetic programs and biomechanical cues, yet the underlying cell-microenvironment interactions remain poorly understood because the developing heart is difficult to study in utero and accurate experimental models are lacking. Recent advances in stem cell biology and three-dimensional (3D) bioprinting now allow the construction of human tissue analogues with defined structure and function. Here we show a perfusable 3D bioprinted model of the human embryonic heart tube composed of layered myocardium, cardiac jelly, and endocardium. Human induced pluripotent stem cell-derived cardiomyocytes and endothelial cells are cultured under controlled flow conditions, producing constructs with high …

Pediatric Thyroid Cancer Lung Metastases And Rai: Long-Term Results, Ryan C Mueller, Nikhil Rammohan, Anthony J Apicelli, Ana Maria Arbelaez, Farrokh Dehdashti, Barry A Siegel, Vikas Prasad, Perry W Grigsby, Stephanie Markovina

2020-Current year OA Pubs

OBJECTIVES: Children with differentiated thyroid cancer (DTC) often present with lung metastases but historically have good outcomes. Radioactive iodine (RAI) is commonly used to treat these children. Given the rarity of this condition, little evidence detailing long-term outcomes and risk of radiation pneumonitis exists.

METHODS: We conducted a retrospective analysis of patients < 20 years old who received RAI for DTC lung metastases between 1973 and 2018. Disease-free survival (DFS) was calculated from diagnosis to last follow-up. Overall survival and rates of acute and late radiation pneumonitis were determined by chart review and obituary searches.

RESULTS: Sixteen patients met eligibility criteria. Fourteen presented with thyroid, nodal, and lung disease; one presented with thyroid and nodal disease with nodal and lung recurrence; and one presented with thyroid-only disease with nodal and lung recurrence. All patients underwent thyroidectomy, 10 underwent neck dissection, and four underwent …

Sex-Aware Genome-Wide Assessment Of De Novo Variants In Autism Across Coding And Noncoding Regions, Tychele N Turner

2020-Current year OA Pubs

BACKGROUND: Autism spectrum disorder (ASD) shows a consistent sex bias, yet how sex shapes de novo variant (DNV) risk across coding and noncoding sequence remains unclear. I analyzed DNVs in > 41,000 parent–child sequenced trios from three ASD family-based cohorts and compared DNV characteristics and enrichment patterns in males and females. Notably, these trios included individuals with ASD as well as those without ASD. I developed a new sex-aware DNV caller (HAT-FLEX) and thoroughly evaluated each candidate DNV using an additional tool introduced in this study, SNOW, to generate a high-confidence callset. RESULTS: I identified enrichment of missense and loss-of-function (LOF) …

Does Improved Reaction Time Correlate With Improvements In Sport Performance? A 10-Week Smart Reaction Training Intervention In Division Ii Collegiate Football Athletes, Caleb M. Forst, Christopher C. Mayer

Research & Creative Achievement Day

Introduction: Neurocognitive reaction time plays a critical role in football performance by influencing perceptual processing speed, decision-making, and motor execution. Slower reaction time has been associated with increased injury risk and reduced neuromuscular control, yet limited longitudinal research exists within Division II collegiate football populations. This study examined whether a 10-week smart reaction training program improves reaction time and whether these improvements are associated with performance outcomes, measured by the number of accurate hits. Methods: Thirty-one athletes from the Winona State Football team began the intervention and were divided into position groups (QB, WR, DL, OL); 19 completed the study. …

Fifteen Years Of The Abc-Ahp-Ncnpr Botanical Adulterants Prevention Program: What Have We Learned?, Stefan Gafner, Roy Upton, Mark Blumenthal, Ikhlas Khan

Oxford ICSB

Initiated in 2011, the Botanical Adulterants Prevention Program (BAPP) was created as a partnership between the American Botanical Council, the 2American Herbal Pharmacopoeia (AHP), and the National Center for Natural Products Research (NCNPR) at the University of Mississippi to educate the herbal dietary supplement industry, regulators, and scientists in academia about adulteration of botanical ingredients. The ultimate goal of the Program was to improve the authenticity and quality of herbal dietary supplements to the consumer. Since its inception, the Program has published 100 peer-reviewed documents. Despite herbal ingredient suppliers’ and dietary supplement manufacturers’ implementation of changes in quality control specifications, …

Gamification As A Strategy For Interprofessional Learning, Chisom S. Enebechi, Aislinn M. Dorko

Research & Creative Achievement Day

Background: A Community-based, student-led clinic provides free health services to underserved areas, bringing together students from allied health disciplines to promote interprofessional collaboration and health promotion. Previous orientation sessions were lecture-based with a team-building activity providing limited opportunities for active learning. To address this, a gamified orientation activity was developed using realistic, scenario-based cases designed to exemplify common community health situations. Purpose: This quality improvement project aims to evaluate whether gamification improves students' perceived ability to communicate, collaborate, and understand roles and responsibilities when delivering team-based care. Methods: The project was guided by Bandura's Social Learning Theory and implemented using …

Evaluating Mental Health Providers’ Knowledge And Attitudes Towards Stigma Among Teenagers Aged 13 To 19 Years With Mental Illness, Fredrica Murray Johnson

Wisdom & Compassion: The LUSON Journal

Limited knowledge and poor attitudes among mental health providers contribute to stigma towards individuals with mental illness, adversely affecting treatment experience and outcomes. This study evaluated the effectiveness of an educational intervention in improving mental health providers’ knowledge and attitudes toward stigma-based practices. The clinical question stated: Among mental health providers, does an educational intervention, compared to standard practice, improve knowledge and attitudes of stigma and promote evidence-based care delivery to adolescents aged 13 to 19 with mental illness within six weeks? The Iowa Model of Evidence-Based Practice (EBP) was the framework used to implement the quasi-experimental study. The two …

Non-Alcoholic Fatty Liver Disease, Diet And Contributing Factors: A Narrative Literature Review, Rachel Joseph, Ashley Tharpe, Sherri Ann Walker

Wisdom & Compassion: The LUSON Journal

Objectives: The purpose of this narrative literature review is to explore the relationship between Non-alcoholic fatty liver disease (NAFLD) and dietary habits, and identify factors that contribute to the development, progression, and potential management of NAFLD.

Methods: Search terms such as non-alcoholic fatty liver disease (NAFLD), diet, and nutrition, including plant-based and vegetarian diets, were used to identify 45 peer-reviewed publications published within the last five years.

Results: Dietary factors, biological, environmental, obesity, mental health, and genetic factors can contribute to the development of NAFLD. This multisystem problem can have economic, social, and psychological consequences that affect a person’s quality …

Resilience In Nursing Education: A Literature Review Examining The Experiences Of Ukrainian Nursing Students In The United States, Katherine Ferrell, Rachel Joseph

Wisdom & Compassion: The LUSON Journal

The purpose of this literature review is to examine the experiences of international students who originate from war-torn areas, who live in the United States (US). Drawing from peer-reviewed sources, the review examines the academic, psychological, and social challenges these students face, including trauma, cultural adjustment, and gaps in institutional support. It highlights the resilience and coping strategies employed by students, as well as the role of universities in fostering inclusive environments. The review also identifies critical gaps in current research, particularly regarding long-term mental health outcomes and culturally responsive support services. This paper aims to synthesize existing literature on …