Medicine and Health Sciences Commons^™

The Il6/Jak/Stat3 Signaling Axis Is A Therapeutic Vulnerability In Smarcb1-Deficient Bladder Cancer, Chandra Sekhar Amara, Karthik Reddy Kami Reddy, Yang Yuntao, Yuen San Chan, Danthasinghe Waduge Badrajee Piyarathna, Lacey Elizabeth Dobrolecki, David J H Shih, Zhongcheng Shi, Jun Xu, Shixia Huang, Matthew J Ellis, Andrea B Apolo, Leomar Y Ballester, Jianjun Gao, Donna E Hansel, Yair Lotan, H Courtney Hodges, Seth P Lerner, Chad J Creighton, Arun Sreekumar, W Jim Zheng, Pavlos Msaouel, Shyam M Kavuri, Nagireddy Putluri

Faculty, Staff and Student Publications

SMARCB1 loss has long been observed in many solid tumors. However, there is a need to elucidate targetable pathways driving growth and metastasis in SMARCB1-deficient tumors. Here, we demonstrate that SMARCB1 deficiency, defined as genomic SMARCB1 copy number loss associated with reduced mRNA, drives disease progression in patients with bladder cancer by engaging STAT3. SMARCB1 loss increases the chromatin accessibility of the STAT3 locus in vitro. Orthotopically implanted SMARCB1 knockout (KO) cell lines exhibit increased tumor growth and metastasis. SMARCB1-deficient tumors show an increased IL6/JAK/STAT3 signaling axis in in vivo models and patients. Furthermore, a pSTAT3 selective inhibitor, TTI-101, reduces …

The Impact Of The Turkish Population Variome On The Genomic Architecture Of Rare Disease Traits, Zeynep Coban-Akdemir, Xiaofei Song, Francisco C Ceballos, Davut Pehlivan, Ender Karaca, Yavuz Bayram, Tadahiro Mitani, Tomasz Gambin, Tugce Bozkurt-Yozgatli, Shalini N Jhangiani, Donna M Muzny, Richard A Lewis, Pengfei Liu, Eric Boerwinkle, Ada Hamosh, Richard A Gibbs, V Reid Sutton, Nara Sobreira, Claudia M B Carvalho, Chad A Shaw, Jennifer E Posey, David Valle, James R Lupski

Faculty, Staff and Student Publications

PURPOSE: The variome of the Turkish (TK) population, a population with a considerable history of admixture and consanguinity, has not been deeply investigated for insights on the genomic architecture of disease.

METHODS: We generated and analyzed a database of variants derived from exome sequencing data of 773 TK unrelated, clinically affected individuals with various suspected Mendelian disease traits and 643 unaffected relatives.

RESULTS: Using uniform manifold approximation and projection, we showed that the TK genomes are more similar to those of Europeans and consist of 2 main subpopulations: clusters 1 and 2 (

CONCLUSION: Our findings support the notion that …

Secretory Leukocyte Protease Inhibitor Protects Against Severe Urinary Tract Infection In Mice, Anne L Rosen, Michael A Lint, Dayne H Voelker, Nicole M Gilbert, Christopher P Tomera, Jesús Santiago-Borges, Meghan A Wallace, Thomas J Hannan, Carey-Ann D Burnham, Scott J Hultgren, Andrew L Kau

2020-Current year OA Pubs

Millions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. Uropathogenic

Yersiniabactin Is A Quorum-Sensing Autoinducer And Siderophore In Uropathogenic Escherichia Coli, James R Heffernan, John A Wildenthal, Hung Tran, George L Katumba, William H Mccoy, Jeffrey P Henderson

2020-Current year OA Pubs

Siderophores are secreted ferric ion chelators used to obtain iron in nutrient-limited environmental niches, including human hosts. While all

Microsporidiosis: Reviewing Clinical Presentation And Treatment Strategies, Julienne Zhou, Belinda Liu, Megan Dearmond, David Banach, Brad Haubrich

Annual Research Symposium

Microsporidiosis is an opportunistic infection caused by obligate intracellular pathogens within the taxon Microsporidia. Infection is zoonotic and has been associated with patients experiencing immunodeficiency, though incidence is increasing among other populations. Most commonly, the disease is gastrointestinal, typically by Enterocytozoon bieneusi and less commonly by Encephalitozoon intestinalis. Symptoms present with diarrhea and vomiting, and severe cases can lead to wasting and mortality. While the incorporation of anti-retroviral therapy for HIV patients has significantly decreased mortality in a subset of the vulnerable populations, treatment for microsporidiosis is still not standardized or well explored. Resistance to first-line treatment albendazole is increasing, …

Evaluating The Impact And Utility Of Medicare Assistance Program (Map) Training Among Roseman University Of Health Science Graduates, Robin Reed

Annual Research Symposium

Medicare Assistance Program (MAP) is a federally-funded initiative in Nevada that provides 1-on-1 counseling to Medicare beneficiaries. In 2016, Roseman University of Health Sciences partnered with MAP to establish an on-campus Medicare Call Center, offering unbiased counseling to beneficiaries. Health sciences students and professionals have an opportunity to attend the 2-day training to become certified MAP counselors. This study aims to investigate the long-term impact of MAP training on the professional practices and careers of Roseman University of Health Sciences (RUHS) graduates.

Influence Of Thickness On The Parameters Of Translucency And Fluorescence Of Direct Bioactive Restorative Materials, Italo Carvalho

Annual Research Symposium

The aim of this study was to assess the influence of different thickness on the parameters of translucency and fluorescence of direct bioactive restorative materials.

Educational Intervention For Delirium Assessment In Intensive Care Units Using The Confusion Assessment Method, Nathan Nguyen, Kaylee Putney, Alana Whittaker

Annual Research Symposium

Delirium frequently occurs in severely ill adults, leading to worse outcomes and increased duration of intensive care unit (ICU) and hospital stays, along with higher associated expenses. The 2018 clinical practice guidelines for Pain, Agitation, Delirium, Immobility, and Sleep Disruption (PADIS) recommend that all adult ICU patients be regularly assessed for delirium. At Valley Hospital Medical Center, the utilization of Confusion Assessment Method for the ICU (CAM-ICU) for monitoring delirium is infrequent, typically taking place either after the adjustment of sedatives or in response to nursing reports of positive neurologic assessments indicating signs of delirium.

Estrogen Level, Osteopenia/Osteoporosis And Periodontal Status In Post Menopausal Women – A Comparative Evaluation, Dr Sanupa S. Madhavan, Dr Anjhana Narayanan

Annual Research Symposium

Osteopenia, Osteoporosis and periodontitis are diseases, which affect a large number of populations across the country and world. Both are silent diseases” which cause bone loss mediated by local and systemic factors. These two diseases also share some risk factors that may interfere with healing.. Estrogen deficiency is the dominant pathogenic factor for osteoporosis in women .Various reports also have linked estrogen deficiency and osteopenia/osteoporosis to increased oral bone resorption , attachment loss and tooth loss .The objective of the study is to analyse and evaluate the condition of periodontal status of twenty five osteopenic/osteoporotic postmenopausal women and their estrogen …

Brushing And Staining Influence On Esthetic Properties Of Attachment Composites, Marcella Rocha

Annual Research Symposium

The aim of this study was to evaluate the brushing and staining influence on esthetic and surface properties of resin composites indicated for aligner attachment.

Exploring The Developmental Effects Of Antidepressants In Caenorhabditis Elegans, Alexandra Van Stone

Annual Research Symposium

It is so important to explore the potential side effects of antidepressants especially if these side effects could lead to a future detriment to an individual’s financial and social well-being. A better understanding of these side effects in regards to human developmental issues is imperative considering issues related to mental health and depression affect a large percentage of the population. In this study, we tested if Caenorhabditis (C.) elegans could be a potential model organism to predict possible side effects associated with select antidepressants. Their developmental problems potentially encountered upon drug treatment may be encountered in humans.

Soft Tissue Secrets: A Comparative Analysis Of Facial Soft Tissue Thickness In Skeletal Class Ii Versus Class I Malocclusions, Jacob Thomas

Annual Research Symposium

This study aimed to measure facial soft tissue thicknesses in adults with skeletal class II malocclusion and compare them to individuals with skeletal class I relationships. The outcomes intended to provide clinicians with data to enhance treatment strategies for facial reconstruction and esthetics.

Ergonomics And Musculoskeletal Disorders Among Dental Students And Practitioners, Ardra Nair S Intern, Sudeep C. B Professor And Head Of The Department Public Health Dentistry

Annual Research Symposium

study to determine the prevalence of musculoskeletal disorders among dental students and dental practitioners in Calicut district.

Challenges In Diagnosing Hepatic Epithelioid Hemangioendothelioma: A Case Series, Aratara Nutcharoen, Elliott Beard, Anupa Thirmiya, Omar Taher, Jacob Adams, Mark Mortensen, John Pelham

Annual Research Symposium

Challenges in Diagnosing Hepatic Epithelioid Hemangioendothelioma

Treatment Of Craniofacial Problems With Stem Cells In Dentistry, Melanie Katz, Mahsa Sadri, George Dresser, Noor Sulaiman, Amir Mohajeri, Connor Schwartz, Man Hung

Annual Research Symposium

To focus on regenerative capabilities and self-renewal abilities of stem cells on bone and tissue regeneration

Pharmacognosy And Trichomoniasis: A Scoping Review Protocol, Claire Hartwell, Melanie Arslanian, Brad Haubrich

Annual Research Symposium

Trichomoniasis, also called “trich”, is the most common non-viral sexually transmitted infection (STI). Its etiological agent is the protozoan parasite Trichomonas vaginalis, against which first-line antiparasitics usually work. However, resistance is on the rise. Trich has traditionally been considered a nuisance infection, with many (particularly AMAB patients) being asymptomatic. But research in recent years has begun to unravel correlations of trichomonal infections with a myriad of comorbitidies, including infertility, cancers, the pathogenesis of AIDS, and pelvic inflammatory disease (PID). Between the rise of drug resistance and the incidence of these comorbidities, new treatments are needed. In this work, we are …

Behind The Spine: Investigating The Role Of Cervical Posture And Range Of Motion On Mental Health, Layla Risdon, Luis Alvarez, Cassidy Byers, Davis Byers, Louis Michelon, Tallon Muhlestein, Natalie Tate, Garret Vincent, Christina Small, David Sant, Kurt Alexander, Kyle Bills

Annual Research Symposium

This research explores the correlation between abnormal forward head posture, cervical range of motion, and psychiatric disorders. Specifically, the study examines the relationships between the loss of cervical lordosis and anxiety, depression, and ADHD. Previous studies have demonstrated the beneficial effect of manipulative therapy on forward head posture and provided a link between postural alignment and cognitive function. This investigation aims to build on existing literature and enhance understanding of how loss of cervical lordosis impacts cervical and overall range of motion as well as its potential association with psychiatric conditions.

Evaluating The Impact Of Low-Level Laser Therapy On Accelerating Orthodontic Tooth Movement, Mcqueen Mendonca

Annual Research Symposium

The prolonged duration of orthodontic therapy is a primary concern for patients. Low-Level Laser Therapy can accelerate bone remodeling and thus, orthodontic tooth movement. This study aimed to assess the efficacy of Low-Level Laser Treatment (LLLT) in enhancing the rate of orthodontic tooth movement during en-masse retraction.

Effectiveness Of Omt On Cardiovascular Function: A Systematic Review., Sarah Legrand

Annual Research Symposium

Vascular disease is responsible for the top two causes of death worldwide. Osteopathic manipulative treatment (OMT) is currently utilized mostly for alleviating musculoskeletal symptoms, but it has shown promise as a non-invasive approach to improve cardiovascular function. There is currently no consensus that OMT can have short-term or long-term effects on cardiovascular function. The utility of OMT in maintaining cardiovascular system health is an emerging area of practice. The purpose of this systematic review project is to investigate the short-term and long-term effects of OMT on cardiovascular function and its regulators in the nervous and endocrine systems.

Porcelain Fused To Zirconia Wing Bridge: A Clinical Trial, Gerald Greenan

Annual Research Symposium

This study evaluated the durability and retention of nine porcelain fused to zirconia wing bridges with the addition of counter sunk holes in the wings. Prior to this clinical trial, preliminary in-vitro testing of bridges with porcelain fused zirconia was performed. The nine bridges were then fabricated for the replacement of missing anterior teeth.

Long Non-Coding Rna As A Potential Diagnostic Tool In Coronary Artery Diseases - A Systematic Review, Arthi Sri A.S, Vishnu Priya Veeraraghavan

Annual Research Symposium

POSTER - SYSTEMATIC REVIEW - LONG NON CODING RNAS AS DIAGNOSTIC MARKER FOR CAD

Influence Of Orthodontic Treatment On Changes In The Maxillary Sinus Dimensions, Eiji Tanaka Dds, Phd, Hiroshi Yamada Dds, Phd, Masaaki Higashino Md, Phd, Saya Suetake Dds, Susumu Abe Dds, Phd

Annual Research Symposium

This study aimed to investigate the correlation of craniofacial morphology with maxillary sinus morphology and to evaluate whether orthodontic treatment facilitates maxillary sinus enlargement in adults.

Correlation Between Salivary Levels And Tissue Expression Status Of Her2 In Breast Cancer Patients - A Cross-Sectional Study, Arthi Sri A.S, Massillamani F, Vinothkumar Thilla Sekar

Annual Research Symposium

The study aims to investigate if soluble salivary human epidermal growth factor receptor-2 (HER2) would play a role in the diagnosis of breast cancer patients and also to find out the influence of demographic and hormonal factors on the salivary HER2 levels in breast cancer.

Root Analogue Implants- The New Route, Subhashini Balaguru

Annual Research Symposium

Dental implants are an excellent option for replacing missing teeth. Traditional implants have a cylindrical or tapered geometry with threads along the screw length. The lack of proper congruency between the implant and the socket bone can eventually lead to implant failure due to stability loss and failure in osseointegration. To overcome this problem, novel approaches are being evaluated to manufacture customized root implants. This is expected to reduce the bone and soft-tissue trauma and promote a better primary stability. They do not require bone drilling, sinus lifting, bone augmentation or other traumatic procedures.

Fit Evaluation Of Soft Milled Zirconia And Cocr By Microcomputed Tomography, Elie Daou

Annual Research Symposium

Statement of problem. The absolute marginal fit of CAD-CAM presintered fixed partial dentures has been poorly documented. Purpose. The purpose of this in vitro study was to evaluate the marginal fit of presintered cobalt-chromium (Co-Cr) and zirconia 3-unit fixed partial dentures by using X-ray microcomputed tomography (mCT).

Material and methods. A metal model was prepared from a typodont to receive fixed partial dentures (N=12). The maxillary first premolar and first molar were prepared with a circumferential 1.2-mm chamfer and 2-mm occlusal reduction. The dies were scanned and assigned to 1 of 2 groups to receive the prostheses made of presintered …

Smile Miles Away: Navigating The Future Of Teledentistry, Farhad Jafeen J, Prem Blaisie Rajula, Pl Ravishankar, Shivani Senthilkumar

Annual Research Symposium

Teledentistry is a combination of telecommunications and dentistry involving the exchange of clinical information and images over remote distances for dental consultation and treatment planning. Teledentists are capable of improving access to oral healthcare, increasing the provision of oral health care and reducing its costs. The disparities in oral health care between rural and urban areas could also be eliminated. This article analyses the origin, rationale, scope, basis and requirements of teledentistry in conjunction with current evidence available in the literature. Ethical and legal issues relating to teledentistry, as well as the future of this alternative and innovative way of …

Double-Blinded Randomized Control Trial Investigating The Efficacy Of Probiotic Mouth Rinse In Enhancing Oral Health, Sudeep C B Prof. Dr., Sunil P M Prof. Dr.

Annual Research Symposium

The efficacy of probiotic mouth rinse in enhancing oral health was investigated through a double-blinded randomized controlled trial involving 45 children aged 12 to 15 over a two-week period. Comparing probiotic mouth rinse, chlorhexidine mouth rinse, and a control group, plaque and gingival accumulation were assessed using established indices. Results indicated both probiotic and chlorhexidine groups exhibited reduced plaque compared to the control, with the probiotic group showing superior reduction in gingival inflammation. These findings suggest the potential of probiotic mouth rinse in improving oral hygiene and overall oral health.

Comparative Efficacy Of Forsus Frd And Twin Block Appliance In Class Ii Malocclusion Correction, Priyanka Udeshi

Annual Research Symposium

The Forsus Fatigue Resistant Device (FRD) and Twin Block appliances are used to correct Class IImalocclusions. Both appliances work primarily through mandibular repositioning. Despite theirwidespread use, uncertainties remain about their specific mechanisms of correction andcomparative effectiveness. Our study aimed to evaluate and compare the dentoalveolar, skeletal,and soft tissue changes between the Forsus FRD and Twin Block appliance in the treatment of ClassII malocclusions.

Validity Of Digital Cephalometric Tracing: A Systematic Review, Alia Chaudhry, Frank W. Licari, Shankargouda Patil

Annual Research Symposium

Aim of this systematic review was to assess the accuracy of digital cephalometric tracing with manual hand tracing.

Investigating Optimal Laboratory Growth Conditions Of Gracilibacillus Halotolerans In Media Supplemented With Salt, Isaac Young

Annual Research Symposium

As interest continues to grow in the field of persister cells and their morphology, there arises an ever-evolving desire to further understand specific strains of bacteria that exemplify the qualities of seemingly anomalous survival regardless of anti-bacterial treatment. In the case of the Gracilibacillus halotolerans, a halotolerant extremophile extracted from the Great Salt Lake with known persistent characteristics, uncovering its optimal growth conditions was essential for future investigations. Identifying the optimal salinity for the growth of G. halotolerans will allow us to standardize our growth methods, uncover several mechanisms of saline tolerance, and add to future investigations of persistence with …