Medicine and Health Sciences Commons^™

Real-Time Camp Dynamics In Live Cells Using The Fluorescent Camp Difference Detector In Situ, Isabella Cattani-Cavalieri, Jordyn Margolis, Camelia Anicolaesei, Francisco J. Nuñez, Rennolds S. Ostrom

Pharmacy Faculty Articles and Research

cAMP Difference Detector In Situ (cADDis) is a novel biosensor that allows for the continuous measurement of cAMP levels in living cells. The biosensor is created from a circularly permuted fluorescent protein linked to the hinge region of Epac2. This creates a single fluorophore biosensor that displays either increased or decreased fluorescence upon binding of cAMP. The biosensor exists in red and green upward versions, as well as green downward versions, and several red and green versions targeted to subcellular locations. To illustrate the effectiveness of the biosensor, the green downward version, which decreases in fluorescence upon cAMP binding, was …

Oral Feeding Of Infants Who Require Noninvasive Respiratory Support: Retrospective Investigations, Carolyn Barnes

MUSC Theses and Dissertations

There is a dearth of evidence supporting the safety and efficacy of orally feeding infants who require noninvasive respiratory support (NIRS). This dissertation investigates clinical practices surrounding orally feeding infants on NIRS. Manuscript 1 systematically reviews parameters impacting study of this practice. Findings emphasize the dearth of objective data surrounding this practice, and that additional research must be conducted before safety and efficacy outcomes of this practice can be established. Manuscript 2 retrospectively uses electronic health record data to describe which infant populations are orally fed during NIRS use, amount of NIRS used during infant oral feeding, changes in practice …

Language Beliefs And Practices Of Caregivers In The Deep South, Maria Maldonado

LSU Master's Theses

The 30 million word gap refers to the disparity in early language exposure between low socioeconomic status (SES) children and their higher SES peers; a gap that is thought to negatively impact children’s language development and future academic success. Although many early intervention approaches have proven effective in promoting language development among low SES children, they often fall short in terms of cultural responsiveness, which in turn affects caregiver buy-in. Culturally and linguistically diverse children disproportionately live in poverty, as such there is a need for research to inform more responsive interventions that take a strengths- based approach and build …

Edge-Wise Analysis Reveals White Matter Connectivity Associated With Focal To Bilateral Tonic-Clonic Seizures, Sam S. Javidi, Xiaosong He, Ankeeta Ankeeta, Qirui Zhang, Salvatore Citro, Michael R. Sperling, Joseph I. Tracy

Farber Institute for Neuroscience Faculty Papers

OBJECTIVE: Focal to bilateral tonic-clonic seizures (FBTCS) represent a challenging subtype of focal temporal lobe epilepsy (TLE) in terms of both severity and treatment response. Most studies have focused on regional brain analysis that is agnostic to the distribution of white matter (WM) pathways associated with a node. We implemented a more selective, edge-wise approach that allowed for identification of the individual connections unique to FBTCS.

METHODS: T1-weighted and diffusion-weighted images were obtained from 22 patients with solely focal seizures (FS), 43 FBTCS patients, and 65 age/sex-matched healthy participants (HPs), yielding streamline (STR) connectome matrices. We used diffusion tensor-derived STRs …

Digital Twins For Health: A Scoping Review, Evangelia Katsoulakis, Qi Wang, Huanmei Wu, Leili Shahriyari, Richard Fletcher, Jinwei Liu, Luke Achenie, Hongfang Liu, Pamela Jackson, Ying Xiao, Tanveer Syeda-Mahmood, Richard Tuli, Jun Deng

Faculty, Staff and Student Publications

The use of digital twins (DTs) has proliferated across various fields and industries, with a recent surge in the healthcare sector. The concept of digital twin for health (DT4H) holds great promise to revolutionize the entire healthcare system, including management and delivery, disease treatment and prevention, and health well-being maintenance, ultimately improving human life. The rapid growth of big data and continuous advancement in data science (DS) and artificial intelligence (AI) have the potential to significantly expedite DT research and development by providing scientific expertise, essential data, and robust cybertechnology infrastructure. Although various DT initiatives have been underway in the …

A Qualitative Phenomenological Study Of Quality Standards For Practicing Credentialed Sonographers And Their Interpretation Of An Advanced Ultrasound Practitioner Credential To Increase Patient Safety Outcomes, Leah Klatt Carroll

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to investigate whether advanced sonographer certification in the Diagnostic Medical Sonographic profession (general, vascular, and obstetrics) would support the national quality initiatives of the Centers for Medicare and Medicaid Services (CMS) that involve accurate diagnosis, patient safety, and lessening medical diagnosis errors. The research question(s) focused on sonographers and their perceptions of an advanced credential for qualified sonographers that could offer career advancement opportunities, adherence to patient safety, and increased quality initiatives in ultrasound departments in the United States. Consenting participants derived on a volunteer basis through the National Society of Diagnostic …

Increasing The Awareness Of Healthcare Violence Risk To Improve Safety In A Community Hospital, Allyson Dalton

Doctoral Dissertations and Projects

The U.S. Bureau of Labor Statistics (2020) identified the current incident rate for nonfatal occupational injuries and illnesses, resulting in days out from work due to intentional injury within the healthcare industry. This statistic was revealed to be 10.4 per every 10,000 full-time employees. This figure is notably five times higher than the non-healthcare worker rate of 2.1 per every 10,000 full-time employees (U.S. Bureau of Labor Statistics, 2020). The purpose of the identified scholarly project is to evaluate the overall impact the integration of a Violent Risk Assessment and utilization of resourceful safety measures have on raising awareness and …

The Missing Link: The Significance Of Mental Health Screenings Post Natural Disasters: An Integrative Review, Chalita Mccormick Ellis

Doctoral Dissertations and Projects

Following a natural disaster, the emotional and psychological demands on survivors are great. In addition to generating suffering, such as bodily injuries, natural disasters impact disaster victims’ lives in catastrophic ways, causing loss of homes, property, and jobs; food insecurities; transportation disruption; and communication difficulties. These events disrupt communities, exacerbating adversities to physical and psychological well-being. This presents a critical need for effective mental health response. Screening specific to post-disaster trauma may assist in identifying clients who require prioritized mental health care. Depression, anxiety, and posttraumatic stress disorder are three common mental health issues that are often triggered by disasters. …

Mental Health Provider Shortage In Rural Communities, Barrow N. Tabe

Doctoral Dissertations and Projects

This study examined the dire issue of mental health provider shortages in rural communities in the South, exploring the unique challenges faced by rural communities in the United States. Rural communities often struggle with limited access to mental health resources, resulting in disparities in care and exacerbating the burden on individuals facing mental health challenges. This study examines existing literature, highlighting the complex nature of the problem, including geographical, socioeconomic, cultural factors, and biblical perspectives that contribute to the shortage of mental health professionals in rural communities. Instrumental challenges identified include the shortage of credentialed mental professionals, lack of healthcare …

Implementation Of An Evidence-Based Toolkit To Improve Colorectal Cancer Screening In A Federally Qualified Health Center, Stephanie Mckithan

Doctoral Dissertations and Projects

The change in payor fee-for-service to value-based care is creating an opportunity for primary care clinics nationally to adjust their focus to meeting key clinical quality measures during patient encounters. Colorectal screening is one of such quality measures. Previous research has shown that early detection saves lives. The guidelines have lowered the recommended age of initial screening to 45 due to the incidence of colorectal cancer in younger patients. But with all the objectives that need to be met in the limited time of the visit, how can nurse practitioners improve their efficiency? This evidence-based project assessed the implementation of …

Developing Health Ministries Beyond The Disparities In The Community, Tasha Renea Berry-Lewis

Doctoral Dissertations and Projects

Since the COVID-19 pandemic, there has been an upswing in the lack of awareness concerning disparities and the lack of resources available in many of the neighborhoods in the Chicagoland area. The Washington Park and Bronzeville areas are two (2) communities among several others in the Chicago area that are considered to be low-income neighborhoods with minimal resources and an increasing concern of disparities. As a church in the community, it is vitally important we provide a place of hope and trust for people to come for help and refuge. Developing a service such as a health and wellness ministry …

A Structured Handoff Report And Its Impact On Patient Experience, Gary N. Hicks

Doctoral Dissertations and Projects

Over the past decade, a fast-moving industry has challenged hospital health systems. Today, hospitals are measured on the effectiveness of healthcare delivery ensuring efficiency, quality, and safety. In addition to the delivery of effective healthcare, hospitals are now accountable for the overall patient experience, a system known as value-based purchasing. Value-based purchasing directly impacts the overall financial status of any healthcare organization and is based on data collected from the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS). Nursing practice can significantly influence the overall impact and outcomes of value-based purchasing by helping with an improvement of HCAHPS. One …

Impacts Of Opioids On Health And Ways To Overcome The Addiction, Kennedy Chidi Alajemba

Doctoral Dissertations and Projects

Background: The opioid crisis in the United States has affected millions of individuals, causing high levels of opioid addiction among the population. With the onset of synthetic opioids, deaths from opioid-related causes have increased drastically. This study aims to understand the effect of opioid addiction and methods of controlling the problem for adult African Americans and Latinos at Pathways to Recovery Counseling and Education Services, Hazleton, Pennsylvania. Methods: The theories guiding this study are the Intersectionality Model and the Bay Area Regional Health Inequalities Initiative (BARHII) model. These theories reveal that factors such as age, ethnicity, and gender have a …

Childhood Cancer Mutagenesis Caused By Transposase-Derived Pgbd5, Makiko Yamada, Ross R Keller, Rodrigo Lopez Gutierrez, Daniel Cameron, Hiromichi Suzuki, Reeti Sanghrajka, Jake Vaynshteyn, Jeffrey Gerwin, Francesco Maura, William Hooper, Minita Shah, Nicolas Robine, Phillip Demarest, N Sumru Bayin, Luz Jubierre Zapater, Casie Reed, Steven Hébert, Ignas Masilionis, Ronan Chaligne, Nicholas D Socci, Michael D Taylor, Claudia L Kleinman, Alexandra L Joyner, G Praveen Raju, Alex Kentsis

Faculty, Staff and Students Publications

Genomic rearrangements are a hallmark of most childhood tumors, including medulloblastoma, one of the most common brain tumors in children, but their causes remain largely unknown. Here, we show that PiggyBac transposable element derived 5 (Pgbd5) promotes tumor development in multiple developmentally accurate mouse models of Sonic Hedgehog (SHH) medulloblastoma. Most Pgbd5-deficient mice do not develop tumors, while maintaining normal cerebellar development. Ectopic activation of SHH signaling is sufficient to enforce cerebellar granule cell progenitor-like cell states, which exhibit Pgbd5-dependent expression of distinct DNA repair and neurodevelopmental factors. Mouse medulloblastomas expressing Pgbd5 have increased numbers of somatic structural DNA rearrangements, …

What Resilience (Strength) Means For Australian Aboriginal And Torres Strait Islander Health Professionals And Practitioners: An Exploratory Study, Eileen Willis, Amy-Louise J. Byrne, Sandy Mclellan, Venessa Curnow, Harvey Clare, Janie Brown, Amelia Britton

Journal of the Australian Indigenous HealthInfoNet

This article explores the concept of resilience from the perspective of Australian Aboriginal and Torres Strait Islander health professionals and practitioners, with the aim of describing what it is and how it is practiced in the workplace. Interviews in the form of Yarns were conducted with ten Aboriginal and Torres Strait Islander health professionals in regional North Queensland. We found that for Aboriginal and Torres Strait Islander health professionals and practitioners, resilience encompasses cultural identity and an ability to manage both Indigenous and western cultures and structures. Resilience, understood as ‘Strength’, draws on strong relationships to family and Country, often …

Use Of A Primary Care Dataset To Describe ‘The Real Picture’ Of Diabetes In Kimberley Aboriginal Communities, Caitlyn S. White, Kimberley Seear, Lorraine Anderson, Emma Griffiths

Journal of the Australian Indigenous HealthInfoNet

Objective
Aboriginal communities are impacted by high rates of diabetes, however these are currently underestimated by national data sources used by policy and decision makers to inform allocation of health resources. We aimed to estimate diabetes prevalence and screening coverage using primary care electronic medical record data.

Methods
A cross-sectional audit was conducted using primary care data from Aboriginal regular Aboriginal Community Controlled Health Service (ACCHS) clinic attendees aged 15 years and over (n=1763) in five remote communities in the Kimberley region. Main outcome measures were overall diabetes prevalence; age-specific diabetes prevalence; prevalence of pre-diabetes; and screening rates among patients …

The Inequitable Burden Of Infectious Diseases Among Remote-Living Aboriginal And Torres Strait Islander Australians: A Product Of History, Stephanie L. Enkel, Rebecca Famlonga, Hannah M. M. Thomas, Nina Lansbury, Jonathan R. Carapetis, Glenn Pearson, Asha C. Bowen

Journal of the Australian Indigenous HealthInfoNet

Insufficient and poorly maintained housing and plumbing in many remote Australian Indigenous communities in Australia results in reduced capacity to maintain personal hygiene, contributing to infectious disease inequalities. Infections from Streptococcus pyogenes (Strep A) and sequalae are often noted to be the result of contextual poverty; a product of over 230 years of discriminatory practice that has excluded Indigenous people from the basic human rights of healthy, maintained housing afforded to most in the nation. The solutions for eliminating diseases of inequity among Australian Indigenous population are known, their success is historically documented, and yet they are to be comprehensively …

The Koolungar Moorditj Healthy Skin Project: Elder And Community Led Resources Strengthen Aboriginal Voice For Skin Health, Bernadette M. Ricciardo, Jacinta Walton, Noel Nannup, Dale Tilbrook, Heather-Lynn Kessaris, Carol Michie, Brad Farrant, Roni Forrest, Annette Garlett, Joanne Hill, Larissa Jones, Natasha Kickett, Sally Smith, Delys Walton, Taleah Ugle, Nadia Rind, Richelle Douglas, Jodie Ingrey, Brenda Carter, Ainslie Poore, Ingrid Amgarth-Duff, Hannah Thomas, Prasad S. Kumarasinghe, Jonathan R. Carapetis, Asha C. Bowen

Journal of the Australian Indigenous HealthInfoNet

In partnership with local Aboriginal Community Controlled Health Organisations, the Elder-led co-designed Koolungar Moorditj Healthy Skin project is guided by principles of reciprocity, capacity building, respect, and community involvement. Through this work, the team of Elders, community members, clinicians and research staff have gained insight into the skin health needs of urban-living Aboriginal koolungar (children); and having identified a lack of targeted and culturally appropriate health literacy and health promotion resources on moorditj (strong) skin, prioritised development of community-created healthy skin resources. Community members self-appointed to Aboriginal Community Advisory Groups (CAG) on Whadjuk (Perth) …

Risk Factors For Neurological Complications And Short-Term Outcomes After Pediatric Heart Surgery: A Retrospective Analysis, ​​Muhammad ​ Shahzad, ​Yasser Abdulrhman ​ Alheraish, ​​Bushra ​ Algethami, Linah Abdulmohsen Algheryafi, Salma Kamel, Rawan Ghunaim, ​​Zohair Yousef ​ Alhalees

Journal of the Saudi Heart Association

Objective: To assess the risk factors associated with neurological complications and poor short-term outcomes following pediatric heart surgery.

Methodology: A cross-sectional study was conducted in a cardiac intensive care unit between June 2019 and June 2022. The data of all children less than 15 years old who underwent open-heart surgery and had CT brain were extracted from hospital records. The primary outcome was the incidence of CNS insult, and secondary outcomes included death after surgery, length of stay in ICU and hospital. Data analysis was performed using SPSS version 23, and a p-value less than or equal to 0.05 was …

Barriers To Hpv Vaccine Acceptance Among Hispanic Immigrants To The Us, Ruth Larson, Brian Poole

Library/Life Sciences Undergraduate Poster Competition 2024

•Hispanics are the largest and fastest growing ethnic minority in the United States, making up 18% of the total population.

•This population has lower rates of vaccination for several vaccines, including the COVID-19, HPV, TDAP, influenza, pneumococcal, and Herpes Zoster (Shingles).

•Due to the lower vaccination rates, Hispanics suffer from a larger proportional disease burden for many diseases than their non-Hispanic counterparts.

•Past studies have focused mainly on language barriers, ignoring the complex and diverse culture of Hispanic immigrants that may make an impact on their vaccine uptake.

• The objective of this study is to identify language and cultural …

Vulnerabilities Of Gender Non-Conforming Children Within The Abcd Study, Mitchell D. Felix, Erik J. Nelson

Library/Life Sciences Undergraduate Poster Competition 2024

• In the broad field of childhood health and development, understanding and caring for society’s most vulnerable populations is vital. One such at-risk population is gender non-conforming children, individuals whose gender expression does not conform to conventional societal norms.1

• Gender non-conforming individuals are likely to be subject to increased discrimination and violence,2 with non-conforming youths specifically seeing elevated rates of harassment by peers and childhood abuse.3,4

• The intersection between gender identity and health outcomes is an emerging field with important applications for policy, practice and societal attitudes.

Preoperative Warming To Improve Patient Outcomes: Implementation Of A Warming Protocol, Tiara Switzer-Houston

Student Scholarly Projects

Practice Problem: Inadvertent perioperative hypothermia (IPH) is noted to be the most common surgical complication. IPH is associated with a variety of complications which are known to impact the well-being of the patient, family, and healthcare system.

PICOT: The PICOT question that guided this scholarly project was scheduled for total hip and knee arthroplasty surgical procedures under general or neuraxial anesthesia greater than 60 minutes (P), how effective is the implementation of an evidence-based pre-surgical warming protocol including forced-air warming (FAW) (I) compared to current practices (C) in improving normothermia readings within 15 minutes of arriving to the PACU, …

A Quantum Logic Gate In The Dna Deoxyribose Moiety, F. Matthew Mihelic

Faculty Publications

The deoxyribose moiety of a nucleotide in the DNA molecule can act as a quantumlogic gate, in which the enantiomeric shift between the C2-endo and C3-endo conformations of each nucleotide, occurs within a logically and thermodynamically reversible situation of electron spin qubits, that are coherently held within the topologically insulating DNA crystalline nanostructure, and that are coherently conducted along the delocalized electrons of the pi-stacked nucleotide base pairs. The enantiomeric symmetry between the C2-endo and C3-endo conformations is logically and thermodynamically reversible because it functions as a symmetry-breaking Szilard engine that is effectively built out of the physicality of the …

Emergent Potential Of The Terahertz Cmos Microprocessor, F. Matthew Mihelic

Faculty Publications

The terahertz speed CMOS microprocessor that has been designed by Averoses Incorporated (US11063118B1) utilizes nano-vacuum tube elements with plasma interconnect of those elements, and has the capability to emit, detect, conduct, and analyze electromagnetic signals in the terahertz range. Nano-vacuum tube systems are resistant to ionizing radiation and to high temperatures, and there are emergent potentials of such systems beyond the obvious speed-up of data processing. Such a microprocessor can provide a platform for compact terahertz spectroscopy, especially for organic molecules, and this can also include DNA sequencing and DNA fingerprinting. Another emergent quality of such a system is that, …

Hormonal Birth Control Effects On The Neurological And Cardiovascular Systems, Alondra Perez, Paige Fink, Adell Riedel

SACAD: Scholarly Activities

Abstract

The present study theoretically investigated the effects of long-term use of hormonal birth control on the female cardiovascular and neurologic systems. The setting will take place at Fort Hays State University campus. Our participants of the survey will include 200 random females ages 16 to 25. This data will be taken from those women who take hormonal birth control versus those females who do not take it on a daily basis. The long-term use of hormonal birth control is creating changes in the neurological and cardiovascular system. Evidence from previous research shows alterations to both the structure and function …

Flipping The Classroom To Improve Knowledge Retention Among Practical Nursing Students, Paige Cooper

SACAD: Scholarly Activities

Typical nursing lectures consist of a power point, and a lecturer discussion of a particular subject, such as a disorders, treatments, or pharmacology (HEW & LO, 2018). Flipping the classroom is a lecture style tailored to a variety of student learning styles, and utilizes prerecorded lectures, and participation in projects or discussions during class time. There are four main learning styles: visual, auditory, kinesthetic, and reading/writing. Each style comes with their own strategies, but all have similar advantages, including the opportunity to learn in the best way for individual students. Flipping the classroom avoids the typical lecture, and implements activities …

Increasing Student Capability To Confront Difficult Topics Through Structured Conversations, Parker R. Carlquist, Lexi Brady, Seth Dotson, Jeff Glenn Dr.

Library/Life Sciences Undergraduate Poster Competition 2024

• Health is shaped by numerous determinants including race, socioeconomic status, education, and personal behaviors
• Addressing determinants often requires the formation and implementation of comprehensive policy
• Public health issues and efforts are intrinsically controversial and can be polarizing
• If individuals are unable to discuss public health issues, long-term viable solutions will not be found
• A dramatic increase in political polarization has occurred since the 1980s leading to less common ground and agreement between political parties on contentious issues4-6
• Research shows reflective structured dialogue improves:
• Polarization attitudes towards openness, tribal identity, and moral disdain
• Knowledge, trust in others, and tolerance of differences …

Investigating The Correlations Between Medicaid And Snap Benefit Levels And Health Outcomes, Will Evans, Michael Barnes, Richard Evans

Library/Life Sciences Undergraduate Poster Competition 2024

• Socioeconomic factors, such as poverty, have statistically significant impacts on health.
• SNAP (formerly known as food stamps) and Medicaid are major government programs that exist to reduce these health-detrimental effects for impoverished households.
• Problem: Determining optimal welfare benefit levels is difficult. Despite vastly different costs-of-living between counties, states offer a standard welfare amount to all counties in the state. Simulating benefits based on geographic living expenses can address the political debate about one-size-fits-all benefits found in most states. Simulating optimal benefits based on achieving optimal health effects is needed to improve SNAP and Medicaid.

Exploring Factors Of Diagnostic Timing Among Black Autistic Youth, Harlee Onovbiona, Lauren B. Quetsch, Emily-Anne Sevilla Del Rosario

Psychological Science Faculty Publications and Presentations

The goal of the present study was to compare profiles among Black families of autistic youth who were identified Early (≤ 2 years of age), Mid (age 3 or 4), and Delayed (≥ 5 years of age) to better identify the characteristics that contribute to early ASD identification and delayed ASD identification. Black caregivers with autistic youth (N = 101) were divided into Early (N = 34), Mid (N = 39), and Delayed (N = 28) groups and compared on (a) the age at which signs of autism signs were first noticed, (b) wait times, (c) …

Temporal Considerations In Brain Metastases Radiation Therapy: The Intersection Of Chronobiology And Patient Profiles, Nicolas Nelson, Sara Burke, Louis Cappelli, Lauren Matlack, Alexandria Smith, Noelle Francois, Joseph Lombardo, Yash Shah, Kuang-Yi Wen, Ayesha A Shafi, Nicole Simone

Department of Radiation Oncology Faculty Papers

The circadian system, a vital temporal regulator influencing physiological processes, has implications for cancer development and treatment response. Our study assessed circadian timing’s impact on whole-brain radiotherapy outcomes in brain metastases for personalized cancer therapy insights. The aim of the study was to evaluate circadian influence on radiation treatment timing and its correlation with clinical outcomes and to identify patient populations benefiting from interventions synchronizing circadian rhythms, considering subgroup differences and potential disparities. An IRB-approved retrospective analysis of 237 patients undergoing whole-brain radiotherapy for brain metastases (2017–2021), receiving over 80% of treatments in the morning or afternoon, was performed. Survival …