Medicine and Health Sciences Commons^™

Extend The Benchmarking Indel Set By Manual Review Using The Individual Cell Line Sequencing Data From The Sequencing Quality Control 2 (Seqc2) Project, Binsheng Gong, Dan Li, Yifan Zhang, Rebecca Kusko, Samir Lababidi, Zehui Cao, Mingyang Chen, Ning Chen, Qiaochu Chen, Qingwang Chen, Jiacheng Dai, Qiang Gan, Yuechen Gao, Mingkun Guo, Gunjan Hariani, Yujie He, Wanwan Hou, He Jiang, Garima Kushwaha, Jian-Liang Li, Jianying Li, Yulan Li, Liang-Chun Liu, Ruimei Liu, Shiming Liu, Edwin Meriaux, Mengqing Mo, Mathew Moore, Tyler J Moss, Quanne Niu, Ananddeep Patel, Luyao Ren, Nedda F Saremi, Erfei Shang, Jun Shang, Ping Song, Siqi Sun, Brent J Urban, Danke Wang, Shangzi Wang, Zhining Wen, Xiangyi Xiong, Jingcheng Yang, Lihui Yin, Chao Zhang, Ruolan Zhang, Ambica Bhandari, Wanshi Cai, Agda Karina Eterovic, Dalila B Megherbi, Tieliu Shi, Chen Suo, Ying Yu, Yuanting Zheng, Natalia Novoradovskaya, Renee L Sears, Leming Shi, Wendell Jones, Weida Tong, Joshua Xu

Faculty, Staff and Student Publications

Accurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling performance of bioinformatics pipelines. A reference sample with a set of known-positive variants was developed in the FDA-led Sequencing Quality Control Phase 2 (SEQC2) project, but the known indels in the known-positive set were limited. This project sought to provide an enriched set of known indels that would be more translationally relevant by focusing on additional cancer related regions. A thorough manual review process completed by 42 reviewers, two advisors, and a judging panel of three researchers significantly …

In Silico Analysis Of C-Type Lectins As Co-Infection Receptors Of Dengue And Chikungunya Viruses In Aedes Aegypti, Munawir Sazali, R. C. Hidayat Soesilohadi, Nastiti Wijayanti, Tri Wibawa, Arif Nur Muhammad Ansori

Makara Journal of Science

Aedes aegypti is a primer vector of dengue virus (DENV) and chikungunya virus (CHIKV). The susceptibility of mosquitoes to DENV and CHIKV depends on their recognition receptor of pathogens. C-type lectins (CTLs) are an important mediator of virus infection in A. aegypti. This study aims to identify potential receptors and determine the binding affinity between ligand–receptor interaction, CTLs and virus envelopes (DENV-1, 2, 3, and 4 and CHIKV) interaction based on in silico analysis. Sample sequences were obtained from GenBank (NCBI), and 10 CTLs were acquired from VectorBase. Homology modeling based on a minimum standard of 20% was processed …

Odevixibat: A Novel Bile Salt Inhibitor Treatment For Pruritus In Progressive Familial Intrahepatic Cholestasis, Farrah E. Flattmann, Farhan S. Mohiuddin, Anjuni Singh, Anamika Tandon, Stewart J. Lockett, Jon D. Hirsch, Chizoba N. Mosieri, Adam M. Kaye, Giustino Varrassi, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye

School of Medicine Faculty Publications

Chronic pruritus is defined as an itch lasting greater than six weeks. It can manifest from a wide variety of etiologies, as many different substances can act as pruritogens, such as steroids, histamine, progesterone, endogenous opioids, and serotonin. In the setting of cholestatic liver disease, increased bile acids play a major role in chronic pruritus. The itching in cholestatic liver disease is worsened in intensity at night and localized frequently to the palms, soles, knees, and other pressure sites. It can be hard to manage, affecting the quality of sleep and causing irritability, poor attention, and, in some cases, depression. …

Tmem106b Coding Variant Is Protective And Deletion Detrimental In A Mouse Model Of Tauopathy, George A Edwards, Caleb A Wood, Yang He, Quynh Nguyen, Peter J Kim, Ruben Gomez-Gutierrez, Kyung-Won Park, Yong Xu, Cody Zurhellen, Ismael Al-Ramahi, Joanna L Jankowsky

Duncan NRI Faculty and Staff Publications

TMEM106B is a risk modifier of multiple neurological conditions, where a single coding variant and multiple non-coding SNPs influence the balance between susceptibility and resilience. Two key questions that emerge from past work are whether the lone T185S coding variant contributes to protection, and if the presence of TMEM106B is helpful or harmful in the context of disease. Here, we address both questions while expanding the scope of TMEM106B study from TDP-43 to models of tauopathy. We generated knockout mice with constitutive deletion of TMEM106B, alongside knock-in mice encoding the T186S knock-in mutation (equivalent to the human T185S variant), and …

Definitions And Measurements For Atypical Presentations At Risk For Diagnostic Errors In Internal Medicine: Protocol For A Scoping Review, Yukinori Harada, Ren Kawamura, Masashi Yokose, Taro Shimizu, Hardeep Singh

Faculty, Staff and Students Publications

BACKGROUND: Atypical presentations have been increasingly recognized as a significant contributing factor to diagnostic errors in internal medicine. However, research to address associations between atypical presentations and diagnostic errors has not been evaluated due to the lack of widely applicable definitions and criteria for what is considered an atypical presentation.

OBJECTIVE: The aim of the study is to describe how atypical presentations are defined and measured in studies of diagnostic errors in internal medicine and use this new information to develop new criteria to identify atypical presentations at high risk for diagnostic errors.

METHODS: This study will follow an established …

Increased Nitrate Intake From Beetroot Juice Over 4 Weeks Affects Nitrate Metabolism, But Not Vascular Function Or Blood Pressure In Older Adults With Hypertension, Rebeka Fejes, Martin Lutnik, Stefan Weisshaar, Nina Pilat, Karl-Heinz Wagner, Hans-Peter Stüger, Jonathan M. Peake, Richard J. Woodman, Kevin D. Croft, Catherine P. Bondonno, Jonathan M. Hodgson, Michael Wolzt, Oliver Neubauer

Research outputs 2022 to 2026

The decline in vascular function and increase in blood pressure with aging contribute to an increased cardiovascular disease risk. In this randomized placebo-controlled crossover study, we evaluated whether previously reported cardiovascular benefits of plant-derived inorganic nitrate via nitric oxide (NO) translate into improved vascular function and blood pressure-lowering in 15 men and women (age range: 56-71 years) with treated hypertension. We investigated the effects of a single ∼400 mg-dose at 3 hours post-ingestion (3H POST) and the daily consumption of 2 × ∼400 mg of nitrate through nitrate-rich compared with nitrate-depleted (placebo) beetroot juice over 4 weeks (4WK POST). Measurements …

Lateropulsion Resolution And Outcomes Up To One Year Post-Stroke: A Prospective, Longitudinal Cohort Study, Jessica Nolan, Angela Jacques, Erin Godecke, Michael Bynevelt, Ferry Dharsono, Barbara Singer

Research outputs 2022 to 2026

Background: Post-stroke lateropulsion is prevalent and associated with poor rehabilitation outcomes; however, data regarding long-term function associated with lateropulsion are lacking.

Objectives: This study aimed to explore lateropulsion resolution and associations between lateropulsion, functional outcomes, and fall occurrence up to 12 months post-stroke.

Methods: Participants for this prospective, longitudinal cohort study were recruited from a Stroke Rehabilitation Unit (SRU). Assessments were conducted at SRU admission, at discharge, and at three, six, nine, and twelve months post-stroke. Outcomes included the Four-Point Pusher Score (4PPS), Functional Independence Measure (FIM), and fall occurrence. Longitudinal outcomes were modeled using generalized linear mixed-effects models. Results: …

What Time Is It? It Is 8-And-A-1/2 Time. A Rare Case About Right Medial Pontine Stroke, Right Ino, Right Facial Colliculus Ischemic Stroke Consistent With Eight-And-A-Half Syndrome., Jessica Marcela Daza, Eunbee Cho, Celia Patricia Daza, Shakirat Ganiyu, Francisco Gomez

Research Symposium

Eight-and-a-half syndrome (EHS) is a rare neuro-ophthalmologic condition characterized by conjugated horizontal gaze palsy, internuclear ophthalmoplegia (INO), and ipsilateral fascicular seventh cranial nerve palsy. Clinical features are attributed to the involvement of the lower pontine, including the abducens nucleus, ipsilateral medial longitudinal fasciculus (MLF), and adjacent facial colliculus. Etiology includes vascular diseases such as pontine infarction or ischemia, demyelinating conditions at the level of the pons, and rarely space-occupying lesions.

Β-Cyclodextrin-Enzalutamide Self-Assembly Complexes For Prostate Cancer Therapy, Meghana Kolli, Rahul Tiwari, Subhash C. Chauhan, Yonghong Zhang, Neeraj Chauhan, Alba C. M, Murali Yallapu

Research Symposium

Background:Castrate circumstances brought on by therapy give rise to castrationresistant prostate cancer (CRPC), which thereafter develops androgen receptor (AR) resistance. AR inhibitors are frequently used to obstruct AR translocation in cells that overexpress AR and slow the progression of cancer by reducing the number of AR receptors that are accessible. In comparison to Bicalutamide, a first-generation AR inhibitor, the hydrophobic drug Enzalutamide has demonstrated higher effectiveness. We investigate Enzalutamide as a viable option for the formation of self-assembly complexes because AR downregulation is still the major treatment for CRPC.

Methods:Enz-loaded self-assembly complexes (enz-β-CD) formulation was developed using solvent …

Update On The Role Of Muc13 In Pancreatic Cancer: A Promising Early Detection Biomarker, Anupam Dhasmana, Swati Dhasmana, Sheema Khan, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan

Research Symposium

Background: With the rise in pancreatic cancer (PanCa) prevalence and mortality rate, by 2030 it will secure second position among leading causes of cancer-related deaths. Due to poor prognosis of PanCa only 11% of PanCa patients have a 5-year survival rate, resulting in an equal mortality rate and incidence rate. 85% of PanCa are Pancreatic ductal adenocarcinoma (PDAC). The main clinical challenge with PanCa is poor treatment outcomes due the late diagnosis. Currently, there are traditional biomarkers panels available for diagnosis, however, these biomarkers do not have optimal sensitivity and specificity for PanCa. Considering this alarming unmet clinic need, our …

Unveiling The Influence Of Transcription Factor Yb1 In Hepatocellular Carcinoma Cell Lines, Yamile Abuchard, Sophia Leslie, Dennis Kwabiah, Ricardo Pequeno Bracho, Ana Ayala Pazzi, Mohammad Hussain, Manish Tripathi

Research Symposium

Background: In the Rio Grande Valley (RGV), Hispanics constitute the predominant ethnic group, accounting for over 94% of the population. Projections for 2023 indicate liver cancer to rank fifth in male and seventh in female mortality. Hepatocellular carcinoma (HCC) manifests as a significant concern within the Hispanic community, influenced by a spectrum of factors—biogenetic, social, and cultural—that intertwine with genetic predispositions and dietary practices. The incidence of HCC is intertwined with various illnesses like hepatitis, liver cirrhosis, drug-induced liver injury (DILI), adding to the burden of cancer. Over the years, HCC prevalence in the RGV has surged by over 35%. …

Unraveling Sorafenib Resistance In Hepatocellular Carcinoma: Exploring Key Facets, Dennis Kwabiah, Kyle Doxtater, Yamile Abuchard, Sophia Leslie, Ricardo Pequeno Bracho, Shaibir Hussain, Manish K. Tripathi

Research Symposium

Hepatocellular carcinoma (HCC) stands as the prevalent form of primary liver cancer worldwide, diagnosing over half a million new cases annually. Surgical interventions like hepatectomy and liver transplantation offer a potential cure for early-stage HCC. However, the prognosis for advanced stages remains grim due to drug resistance, particularly with high refractoriness rates. Sorafenib, a tyrosine kinase inhibitor, is an approved treatment for advanced HCC. Despite its use, the overall survival extension for these patients remains limited due to the drug's ineffectiveness, and the mechanism behind advanced HCC's resistance to sorafenib remains elusive. TCGA analysis of HCC patient cohorts reveals elevated …

Too Yellow: An Idiopathic Case Of Autoimmune Hemolytic Anemia, Shreel Patel, Kashif Ali, Donnel Dockery-Joseph, Eunbee Cho, Sriharsha Koneru, Taha Al Hassan, Aramide Tijani, Elimar Gonzalez Morales

Research Symposium

Background: Autoimmune hemolytic anemia is caused by autoantibodies that react with self red blood cells and cause them to be destroyed. Warm AIHA, due to antibodies that are active at body temperature, is the most common type of the AIHA. It is mostly caused by the underlying disease like infections, autoimmune disorders, lymphoproliferative disorders, immunodeficiency or physiologic state like pregnancy. Rarely it happens that there is no underlying cause. Therefore, here we present a case of idiopathic autoimmune hemolytic anemia without any underlying cause.

Case Discussion: A 77 year old lady with known history of the diabetes mellitus type 2, …

Trimeric Antp-Tbp Complexes With Tfiieβ And Exd Modulated The Transcriptional Activity Of Antp, Norma C. Hernández-Bautista, Claudia A. Altamirano-Torres, Ruben Montalvo Mendez, Gustavo Jiménez-Mejía, Diana Reséndez-Pérez

Research Symposium

Homeoproteins are transcription factors that bind to DNA through a highly conserved binding domain known as the homeodomain (HD), which recognizes short regions rich in A-T. This DNA binding triggers the modulation of multiple target genes responsible for identity in various structures along the A-P axis of D. melanogaster. However, the high similarity of homeodomains and their affinity for widely distributed sites in the genome poses the "Hox paradox," which seeks to explain how homeoproteins acquire functional specificity so precisely. Previous evidence shows that homeoproteins like Antennapedia (Antp) form dimers with cofactors and other transcription factors to modulate their …

The Role Of Oral Microbiota In Periodontitis And Alzheimer's Disease, Noah Al-Hassan, Taha Al Hassan, Juan C. Lopez-Alvarenga, Maria Quinones, Seratna Guadarrama

Research Symposium

Background: Periodontal disease (PD), affecting 20-50% of the global population is marked by biofilm-induced inflammation in oral tissues. Chronic PD results in systemic complications such as heart disease, stroke, and Alzheimer's. The red complex microbes, Porphyromonas gingivalis and Treponema denticola, play a pivotal role, penetrating the blood-brain barrier and contributing to neurodegeneration. Alzheimer's disease (AD), an irreversible neurodegenerative disorder, is linked to abnormal protein cleavage and potentially involves microbiologic components, including gram-positive cocci. Research suggests the presence of bacteria such as Porphyromonas, Actinomyces, and Treponema in autopsied AD brains. Investigating the microbiologic connection between PD and AD is crucial, considering …

Medical School Watercooler Newsletter - March 24, 2024, Lindsey Lyle

Watercooler Newsletter

This is the March 24, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include

• ODI Staff to discuss health disparities and equities
• Whiddon College of Medicine welcomes new associate dean for finance and administration
• Special OB-GYN grand rounds to focus on Black maternal mortality
• Meet a Med Student: Kramer Crider
• USA investigators identify potential biomarker for early pancreatic cancer diagnosis
• The Final Countdown: Doc Rock is Thursday Night
• DiPalma honored at 19th Annual Distinguished Alumni & Service Awards

Emotional Support Animals And Mental Health, Kyla E. Barnett, Kaia Miller

SACAD: Scholarly Activities

Depression and anxiety disorders are a significant problem in adults and teenagers. These disorders continue to increase in prevalence year by year. One way to combat this is the use of emotional support animals (ESA’s), which have become increasingly popular. This study investigates the relationship between the use of emotional support animals and mental well-being of students with mental health disorders. This study is designed to illustrate the increase in sense of well-being in patients with mental health disorders who utilize ESA’s. This study applies both a qualitative and quantitative study design, the qualitative design of this study is phenomenological. …

Effects Of Postpartum Depression On Mothers And Children, Natalie Taylor, Kennedy Harrington, Jeffrey Wick

SACAD: Scholarly Activities

Postpartum depression plagues many women in today’s society. To look deeper into postpartum depression, we questioned who could be affected other than the mother in this issue? The objective of this study is to analyze how postpartum affects children’s cognitive and behavioral development. We investigated cognitive and behavioral development of children 1-3 years old. Our research design of this study was a non-experimental observation approach. The setting used for our research was the Women’s Health Center at HaysMed. This research focuses on patients in the obstetrics department who recently gave birth. Participants of this study were the children of 75 …

Characterizing Antibiotic Regimen Modification Behavior, Patient Characteristics, And Outcomes For Patients With Gram-Negative Bacterial Infections, A Retrospective Single-Center Study, Jason Yamaki, Mirna Mikhail, Richard Beuttler, Philip Robinson, Emre Yücel, Alexandre H. Watanabe

Pharmacy Faculty Articles and Research

Few studies describe the frequency of antibiotic regimen modification behaviors in the acute care setting. We sought to ascertain patient and treatment characteristics, details of regimen modification, and clinical outcomes with antibiotic modifications. This retrospective study included patients admitted to Hoag Memorial Hospital from 1 January 2019–31 March 2021 with a complicated infection caused by a Gram-negative organism resistant to extended-spectrum cephalosporins or with the potential for resistance (AmpC producers). A total of 400 patients were included. The predominant sources were bloodstream (33%), urine (26%), and respiratory (24%), including patients with multiple sources. The most isolated organisms were Pseudomonas spp. …

Pharmacological Interventions Versus Non-Pharmacological Interventions On Pain In Chronic Pain Patients, Harley Page, Olivia Mcswain

SACAD: Scholarly Activities

The study is a comparison experiment that looks at the different types of interventions to treat chronic pain. This study is set at Haysmed Rehabilitation to gather data on adult patients with chronic pain. When studying the interventions used for chronic pain, we found numerous ways of treatment. They are categorized as pharmacological and non-pharmacological interventions. During the study we found, that an understanding of what is causing the pain and the use of both interventions is the best way to go about treating/managing chronic pain.

Use Of An Electronic Health Record System In The Nursing Education Lab & Simulation Setting, Easlyn Koch

SACAD: Scholarly Activities

Simulation has become a significant component of nursing education in recent years, especially with the increasing demand for high-fidelity simulations. However, nursing education struggles to keep up with the ever-changing healthcare technology, specifically electronic health records (EHR). Integrating EHRs into nursing education in areas such as the lab or simulation settings has the potential to impact overall patient safety, familiarity with similar technology, critical thinking skills, and practice readiness of student nurses. A review of the literature was performed, and it was found that the implementation and integration of an EHR in nursing education has overwhelming effects on overall student …

Undergraduate Nursing Education Simulation Training Using Virtual Reality Goggles And Teamstepps Methodology, Jennifer Koalenz

SACAD: Scholarly Activities

Abstract

Due to changes in educational processes during global pandemic restrictions and the rapid pace of innovation and developments in virtual reality technology, this modality of education is expected to become a common presence in healthcare education. Immersive simulation activities can be an effective way to facilitate collaboration and communication skills in a constructivist-based classroom. Evidence shows that virtual simulation improves critical thinking skills, psychomotor skills, and decision making (Padilha et al., 2019). In addition, the availability of an on-demand, customizable scenario is highly useful to supplement clinical learning when necessary. But many caution that virtual simulation, just like any …

Advancing Primary Ciliary Dyskinesia Diagnosis Through High-Speed Video Microscopy Analysis, Wilfredo De Jesús-Rojas, Zachary J Demetriou, José Muñiz-Hernández, Gabriel Rosario-Ortiz, Frances M Quiñones, Marcos J Ramos-Benitez, Ricardo A Mosquera

Faculty, Staff and Student Publications

Primary ciliary dyskinesia (PCD) is an inherited disorder that impairs motile cilia, essential for respiratory health, with a reported prevalence of 1 in 16,309 within Hispanic populations. Despite 70% of Puerto Rican patients having the RSPH4A [c.921+3_921+6del (intronic)] founder mutation, the characterization of the ciliary dysfunction remains unidentified due to the unavailability of advanced diagnostic modalities like High-Speed Video Microscopy Analysis (HSVA). Our study implemented HSVA for the first time on the island as a tool to better diagnose and characterize the RSPH4A [c.921+3_921+6del (intronic)] founder mutation in Puerto Rican patients. By applying HSVA, we analyzed the ciliary beat frequency …

[Discussions] Vol. 19 Iss. 1

Discussions

This issue of Discussions was published for the Spring 2023 cycle.

Review Of The Safety And Efficacy Of Trauma-Focused Treatment Among Patients With Psychosis, Mary Eggers

Discussions

Among people who experience psychosis, many have comorbid post traumatic stress disorder (PTSD) that is frequently undiagnosed and untreated. Symptoms have long-term implications, such as hallucinations, posttraumatic intrusions, and an increased risk of physical health conditions, like heart disease and respiratory issues. Many clinicians believe that diagnosing and treating PTSD in this population will be dangerous, so these patients are often excluded from trauma-focused treatment based on their psychosis symptoms. This paper will review current data regarding the rates of undiagnosed PTSD among this population as well as the safety and efficacy of treatment options. PubMed was used to identify …

The Increasing Prevalence Of Cleft Lip With Or Without Cleft Palate In The Rio Grande Valley Of Texas, Yossef Alsabawi, Aaron I. Dadzie, Tyler Torres, Elias Arellano, Paul A. Berry

Research Symposium

Background: Orofacial clefts are a subset of birth defects that include cleft lip with or without cleft palate (CLP) and cleft palate alone (CP). The treatment for orofacial clefts is surgical repair, ideally within the first six months of life. Their impacts on patients and families are various and substantial. Babies with orofacial clefts can have trouble with breastfeeding, speech, recurrent ear infections, and hearing loss as they age. Additionally, there is a significant economic burden, with the average repair costing nearly $20,000, not including the costs of medical devices, postoperative care, and rehabilitation. Additionally, children with orofacial clefts face …

The Dog That Broke My Heart, Eunbee Cho, Shakirat Ganiyu, Edgar Dorsey Trevino, Elimar Gonzalez Morales, Johanne Chaglasian

Research Symposium

Introduction: Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy or "broken heart syndrome" is a reversible form of acute heart failure characterized by temporary left ventricular dysfunction, typically precipitated by intense emotional or physical distress. Its clinical presentation mimics that of acute coronary syndrome with chest pain, shortness of breath, elevated troponins, and sometimes with electrocardiogram(EKG) changes, which makes initial diagnosis challenging. This case report presents a Takotsubo cardiomyopathy in an 81-year-old female, which developed after the loss of her beloved Basenji puppy.

Case Report: An 81-year-old female presented to the emergency department(ED) with worsening dyspnea for one day. On the …

The Cardiac Cost Of Cancer Care: Atezolizumab-Induced Dilated Cardiomyopathy, Jian Garcia Cruz, Conrad Chouinard, Elimar Gonzalez Morales, Martha Solis, A. Pena

Research Symposium

Atezolizumab is a humanized immunoglobulin G1 (IgG1) monoclonal antibody that binds to programmed cell death-ligand 1 (PD-L1) and blocks interactions with the PD-1 and B7.1 receptors on activated T cells. It activates PD-L1/PD-1 pathway-mediated inhibition of the immune response, leading to activation of an anti-tumor effect. This drug is commonly used for urothelial cancer, non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), breast cancer, and hepatocellular cancer. Many side effects of this medication have been listed, but the most common cardiovascular effects are arrhythmia (1%), hypotension (5%), myocarditis (rare), and venous thromboembolism (4%). We present a case of …

Stress Hormone And Heart Rate Responses To Various Exercise Training Methods, Tomas Gomez Jr., Rebekah Schlatter, Megan Zamora, Marco Arriago, Sue Anne Chew, Murat Karabulut

Research Symposium

Background: Blood Flow Resistance (BFR) training has garnered attention for its ability to induce positive physiological adaptations with low-load resistance exercise. The present study aimed to examine the responses of catabolic hormones and heart rates (HR) to various BFR training protocols. This investigation seeks to provide insights into the stress levels induced by different protocols and identification behind the most effective protocol for optimal positive exercise-related adaptations.

Methods: Study population involved 10 healthy adult males (height: 175.0±5.0 cm, weight: 96.67±26.6 kg, age: 21.3±2.67 yr.) in a five-session investigation. Informed consent paperwork, pre-testing and anthropometric measurements served as session 1; sessions …

Risk Of Food Insecurity Reflects Health Status In Adult Relatives Of Prek Children – ​ Data From The Steps Snap-Ed Research Study​, Lisa M B Salinas, Karla Cortez, Brenda Rodriguez, Joseph Reyes, Moises Cisneros, Elizabeth Alanis, Zasha Romero, Lin Wang, Juan C. Lopez-Alvarenga, Roberto Treviño-Peña

Research Symposium

Background: Past research shows a correlation between household food insecurity and chronic medical conditions such as diabetes in the general U.S. population as well as metabolic syndrome-related cardiometabolic markers in Hispanic/Latino youth. Furthermore, minority status, including Hispanic/Latino identity, shows an association with low food security and diabetes. The Hunger Vital Sign (HVS) is a validated screener designed to assess risk of food insecurity within households. This study analyzes associated factors related to the screener’s 2 questions, specifically targeting PreK 4-year-old children and their household relatives. The first question assesses concern about food running out before obtaining more due to financial …