Medicine and Health Sciences Commons^™

Play Is A Way Of Life: Play-Based Program For Parents Of Young Children (Ages Two To Five Years Old), Lauren Purdom, Angela Labrie Blackwell, Amanda Perdue Owen

Spring 2024 Virtual OTD Capstone Symposium

This play-based program was created for parents of young children (ages two to five years old) and is accessible through a website called "Play is a Way of Life". Within this program it includes, educational material on the differences between active and passive play and recommendations for each type of play that children in this age group should participate in each day. It also includes a 6-week program with a variety of active play activities that target specific skills that children (ages two to five years old) should participate in for their overall development.

The Ci-Asd Program: Implementation Of Contextual Interventions For Autism Spectrum Disorder (Ci-Asd) With Latino Families (Preliminary Report), Gabriel Gonzalez, Erik Pérez, Angela Blackwell

Spring 2024 Virtual OTD Capstone Symposium

Children diagnosed with Autism Spectrum Disorder (ASD) experience sensory processing differences that affect their participation in daily activities and routines. Autism affects an estimated 1 in 36 children in the U.S. However, Latino children are diagnosed two years later than white children. Latino families still have the greatest disparities in accessing ASD resources throughout the U.S. compared to white families. The lack of ASD services and resources led to decreased parental self-efficacy, quality of life, and increased child behavioral problems.

Contextual Interventions Adapted for Autism Spectrum Disorder (CI-ASD) are an emerging intervention for occupational therapy (OT) practitioners. Recent literature shows …

Kajian Literatur Distribusi Kompensasi Dampak Tempat Pengelolahan Sampah Terpadu (Tpst) Bantargebang: Analisis Keadilan Distributif Dan Keadilan Sosial, Wahyu Pratama Tamba

Jurnal Ilmu Kesejahteraan Sosial

The waste problem in Jakarta is a complex issue related to the large volume of waste, dependence on Bantargebang TPST, and the various environmental impacts caused. Waste from Jakarta brought to Bantargebang TPST reaches 6,500-7,000 tons daily. This TPST hurts the environment and the health of the surrounding community, as well as the risk of ARI, air pollution, groundwater pollution, and environmental aesthetics. As compensation for these negative impacts, the DKI Jakarta Provincial Government allocates compensation funds for affected communities. This is regulated in Article 10 letter (e) of DKI Jakarta Regional Regulation number 4 of 2019 which states that …

Telaah Konsep Asset Bassed Comunity Development Bagi Pembangunan Pariwisata Berbasis Masyarakat, Silva Amanda, Rudi Saprudin Darwis

Jurnal Ilmu Kesejahteraan Sosial

The tourism sector is one of the sectors that contributes the largest foreign exchange in Indonesia. To develop this, the Ministry of Tourism and Creative Economy continues to encourage the community-based tourism industry, with one of them developing a tourist village program. One way to realize the tourist village program in Indonesia is to use the Asset Based Community Development approach by emphasizing the use of potential assets owned by an area. The purpose of this research is to identify the potential or assets that exist in a village/region that can be developed into a tourist village by emphasizing community …

Intouch Week Of April 1, 2024, New York Medical College

InTouch

• Days of Giving Raises $331,271 for Student Scholarships
• NYMC Hosts TB in the Hudson Valley Symposium
• NYMC Celebrates Golf Simulator Grand Opening
• LCME Element of the Week
• Faculty Spotlight: From Classical Music to Hi-Tech Apps, Eric L. Altschuler, M.D., Ph.D., Shares His Passion for Neuroscience and Rehabilitation Medicine

Cell-Type Specific Molecular Expression Levels By Restricted-Dimensional Cytometry, David Kaplan, Hillard M. Lazarus

Faculty Scholarship

Background: Cytometric analysis has been commonly used to delineate distinct cell subpopulations among peripheral blood mononuclear cells by the differential expression of surface receptors. This capability has reached its apogee with high-dimensional approaches such as mass cytometry and spectral cytometry that include simultaneous assessment of 20–50 analytes. Unfortunately, this approach also engenders significant complexity with analytical and interpretational pitfalls. Methods: Here, we demonstrate a complementary approach with restricted-dimensionality to assess cell-type specific intracellular molecular expression levels at exceptional levels of precision. The expression of five analytes was individually assessed in four mononuclear cell-types from peripheral blood. Results: Distinctions in expression …

Clinical And Sociodemographic Characteristics As Predictors For Quality Of Life In Transmasculine And Transfeminine Individuals Receiving Gender-Affirming Hormone Therapy, Saloni U. Lad, Jacob Sinopoli, Britt Conroy, Adam T. Perzynski, Juan P. Del Rincon

Faculty Scholarship

Healthcare systems and providers have increasingly acknowledged the role and impact of social determinants in overall health. However, gender-diverse individuals face persistent health disparities due to their identities. There is limited research on the impact of clinical and sociodemographic characteristics on mood and quality of life (QoL) for transgender (TG) individuals. Our study aims to understand and better elucidate social and clinical characteristics of transmasculine (TM) and transfeminine (TF) individuals and their impact on quality of life and depressive symptoms. In this cross-sectional study, 298 TF and TM individuals on gender-affirming hormone therapy (GAHT) were surveyed about their demographic characteristics …

Beyond The Looking Glass: Dreams And Somnial States And Spaces In Nineteenth-Century British Literature, Anne N. Nagel

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Poised between a waning magico-theological tradition of symbolic dream interpretation and the rising influence of scientific dream theories, which equated dreaming with disorder, the dream occupied a unique space in nineteenth-century Great Britain. Dreams were coming untethered from signification, as natural philosophers deemed their content indecipherable and chaotic. Yet vestiges of early modern beliefs could still lend supernatural power and polyphony to dreams.

This was not simply a matter of making a binary choice between two ways of thinking about dreams but instead a site of collisions and coalescences. I contend that the ways in which dreams were conceptualized in …

A Word From The Writing Team (April 2024), Pam Walter, Mfa, Liz Declan, Ma, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• Join Us for Our Virtual Writing Retreat on April 5th
• Attend a Packback Workshop
• Check Out the Spring 2024 Research Support Newsletter
• Learn about the Ethics of AI at Jefferson's Research Compliance Symposium
• Attend a Reception for the Drs. Theresa and Charles Yeo Writing Prize Winners on April 25th
• Publication Spotlight
• Jefferson's AI Library Guide is Available on the Library Website
• The OPWPC Canvas Page Offers Helpful Tools
• Scott Memorial Library Archive Renovations are Almost Done!
• Wiley Open Access Fees Waived for Jefferson Authors

Introduction To The Special Centennial Issue, Woodward S. Bousquet, Christopher Osgood

Virginia Journal of Science

This special issue of the Virginia Journal of Science (VJS) is dedicated to the 2023 Centennial of the Virginia Academy of Science (VAS). It includes congratulations from Commonwealth leaders, a proclamation by the Virginia General Assembly Senate, Academy members’ personal reflections, several historical papers and summaries, and portions of the program for the May 25-26, 2023 Annual Meeting in Williamsburg on the William & Mary campus.

Reflections About The Academy And Its Centennial, Marco Aldi, Woodward S. Bousquet

Virginia Journal of Science

Brief reflective essays from members of the Virginia Academy of Science were solicited as part of the Academy's centennial commemoration in 2023. The essays received demonstrate the many and varied ways in which the Academy has fostered collegiality, encouraged research, supported science education, and shaped the course of science in Virginia during the organization's 100-year history.

Intercellular Communication Via Gap Junctions Influences Stem Cell Therapy, Madison Bohatuk, Megan Bohatuk, Lauren Harmon

Honors Projects

Adult somatic stem cell therapy can be beneficial for cardiac muscle recovery following injury to the heart. However, a common problem with various approaches to this therapy has been the early (< 24 hrs) loss of a large percentage of the implanted stem cells, which decreases their therapeutic potential. We have demonstrated that cell coupling occurs between stem and cardiac cells through Cx43 gap junctions.Thus, we hypothesize that gap junctions may act as conduits for molecular apoptotic signals from injured cardiac muscle cells that impair the viability of implanted stem cells ('Bystander Effect' ). In our initial experiments, we will use a fluorescently-tagged RNAi control oligo to transfect mouse bone marrow-derived mesenchymal stem cells (mBM- MSCs) and measure transfection efficiency with fluorescence-activated cell sorting (FACS). Additional studies will determine mBM-MSC Cx43 protein expression and the level of Cx43 protein down-regulation in the mBM-MSCs.

Effects Of The Communities That Heal (Cth) Intervention On Perceived Opioid-Related Community Stigma In The Healing Communities Study: Results Of A Multi-Site, Community-Level, Cluster-Randomized Trial, Alissa Davis, Hannah K. Knudsen, Daniel M. Walker, Deborah Chassler, Karsten Lunze, Philip M. Westgate, Emmanuel Oga, Sandra Rodriguez, Sylvia Tan, Janae Holloway, Sharon L. Walsh, Carrie B. Oser, R. Craig Lefebvre, Laura C. Fanucchi, Lashawn Glasgow, Ann Scheck Mcalearney, Hilary L. Surratt, Michael W. Konstan, Terry T-K Huang, Patricia Lebaron, Julie Nakayima, Michael D. Stein, Maria Rudorf, Monica Nouvong, Elizabeth N. Kinnard, Nabila El-Bassel, Jess Tilley, Aaron Macoubray, Caroline Savitzky, Amy Farmer, Donna Beers, Pamela Salsberry, Timothy R. Huerta

Behavioral Science Faculty Publications

BACKGROUND: Community stigma against people with opioid use disorder (OUD) and intervention stigma (e.g., toward naloxone) exacerbate the opioid overdose crisis. We examined the effects of the Communities that HEAL (CTH) intervention on perceived opioid-related community stigma by stakeholders in the HEALing Communities Study (HCS).

METHODS: We collected three surveys from community coalition members in 66 communities across four states participating in HCS. Communities were randomized into Intervention (Wave 1) or Wait-list Control (Wave 2) arms. We conducted multilevel linear mixed models to compare changes in primary outcomes of community stigma toward people treated for OUD, naloxone, and medication for …

Barriers To Opioid Use Disorder Treatment Among People Who Use Drugs In The Rural United States: A Qualitative, Multi-Site Study., T. J. Stopka, A. T. Estadt, G. Leichtling, J. C. Schleicher, L. S. Mixson, J. Bresett, E. Romo, P. Dowd, S. M. Walters, A. M. Young, W. Zule, P. D. Friedmann, V. F. Go, R. Baker, R. J. Fredericksen

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: In 2020, 2.8 million people required substance use disorder (SUD) treatment in nonmetropolitan or 'rural' areas in the U.S. Among this population, only 10% received SUD treatment from a specialty facility, and 1 in 500 received medication for opioid use disorder (MOUD). We explored the context surrounding barriers to SUD treatment in the rural United States.

METHODS: We conducted semi-structured, in-depth interviews from 2018 to 2019 to assess barriers to SUD treatment among people who use drugs (PWUD) across seven rural U.S. study sites. Using the social-ecological model (SEM), we examined individual, interpersonal, organizational, community, and policy factors contributing …

Something's Gnawing At Me, Catharine Kral, Brian Harvey

Posters

17-year-old female presented to Sports Medicine clinic with a chief complaint of bilateral hip pain and difficulty walking who was found to have bilateral ovarian teratoma.

Effect Of Layer Thickness, Inner Structure, And Implant Angulation On The Accuracy Of 3d Printed Models With Implant Analogs, Omar Elsergany

Dentistry

Objective: This study evaluated the effect of layer thickness, model inner structure, and im- plant angulation on the accuracy of 3D printed models with repositional analogs.

Materials and methods: 126 models designed to receive all-on-4 implant retained fixed den- tal prosthesis were 3D printed. Models were divided into 2 groups (n=63) according to posterior implant angulation (Group 1; 30 ̊ and group 2;45 ̊). The models were then divided into three sub- groups (n=21) according to the printing layer thickness (Group a; 50 μm, group b; 100 μm, and group c; 150 μm). Each subgroup was later subdivided into 3 …

Color Stability And Marginal Adaptation Of Ceramic Veneers Cemented Using Different Composite Resins, Basma Refaat Fayad, Maged Zohdy, Engy Adel Farag, Ghada Hussein

Dentistry

BACKGROUND: The purpose of this study was to compare the color stability and marginal adaption of lithium disilicate veneers before and after thermocycling using various resin composite materials employed as cement. METHODS: Laminate veneer preparation was done on an acrylic tooth according to standardized procedures. The veneer preparations were duplicated into twenty-one dies. The veneers were fabricated from lithium disilicate using the CEREC in Lab system. According to the cement type, the twenty-one die specimens were randomly divided into three equal groups: group I, with light cured adhesive resin cement (N.=7), group II, with owable light cured composite, and group …

From Cough To Crip: The Development Of Codeine From A Purely Medical Substance Into A Popular Recreational Drug, Rhett C. Vaughn

Senior Theses

The research that was conducted aimed to elicit the influence that pop culture has on recreational drug consumption. Specifically, the usage of the drug codeine has become very popular in social media among many influencers. The research focuses on the prevalence of this drug across several media platforms, alongside the growing rate of consumption globally. Research was conducted primarily through combining various databases at various organizations and this study aims to compile the data into one coherent paper regarding codeine in pop culture. While, it cannot be solely attributed to one specific outlet or influence, this study found that alongside …

Transcriptional Signature Of Durable Effector T Cells Elicited By A Replication Defective Hcmv Vaccine, Xiaohua Ye, David J H Shih, Zhiqiang Ku, Junping Hong, Diane F Barrett, Richard E Rupp, Ningyan Zhang, Tong-Ming Fu, W Jim Zheng, Zhiqiang An

Faculty, Staff and Student Publications

Human cytomegalovirus (HCMV) is a leading infectious cause of birth defects and the most common opportunistic infection that causes life-threatening diseases post-transplantation; however, an effective vaccine remains elusive. V160 is a live-attenuated replication defective HCMV vaccine that showed a 42.4% efficacy against primary HCMV infection among seronegative women in a phase 2b clinical trial. Here, we integrated the multicolor flow cytometry, longitudinal T cell receptor (TCR) sequencing, and single-cell RNA/TCR sequencing approaches to characterize the magnitude, phenotype, and functional quality of human T cell responses to V160. We demonstrated that V160 de novo induces IE-1 and pp65 specific durable polyfunctional …

The Bloodless Period: A Transfeminine Experience, Rin Nguyen

College of Education and Human Sciences: Dissertations, Theses, and Student Research

There is limited research exploring menstruation in transgender and gender diverse (TGD) populations, and studies have primarily examined the relationship between menstruation and gender congruence. Findings revealed menstruating TGD people experienced distress related to decreased gender congruence (Eisenberg et al., 2021), and 88% of TGD people expressed interest in menstrual suppression to manage the distress (Schwartz et al., 2022). By contrast, Lowik (2020) highlighted a transfeminine person who wished to menstruate to achieve womanhood and commented on the “bloodless period” (i.e., menstrual-like symptoms in the absence of bleeding) upon receiving gender-affirming hormone therapy. To the author’s knowledge, there is no …

Establishing Consent: The Role Of Women Representatives In Passing Informed Consent Laws, Sophia Stockham

Department of Political Science: Dissertations, Theses, and Student Research

What predicts the adoption of informed consent laws for pelvic exams within the United States? As of January 2023, 22 states have adopted informed consent laws for pelvic examinations on women, with eleven being under Democratic control, six being Republican control, and five with divided control between the legislature and gubernatorial level at the time of adoption. Little attention, however, has been given to women’s health mandates outside the issue of abortion and to variation among state partisan adoption regarding informed consent for pelvic exams. This paper examines the impact of partisanship, the percentage of women in the legislature, and …

Novel Insights Into The Autoimmune Mechanisms In Coxsackievirus B Infections And Their Prevention By Vaccination, Mahima Theresa Rasquinha

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Coxsackievirus Bs (CVBs) are RNA viruses of the genus Enterovirus belonging to the Picornaviridae family. CVBs commonly infect humans, and multiple CVB types can induce similar diseases such as myocarditis, pancreatitis, and type 1 diabetes (T1D). Although CVB infections can lead to the generation of autoantibodies, their role in disease is poorly defined, and vaccines are not available to prevent or minimize these infections. To fill these gaps, we first analyzed the autoantibody repertoire in mice infected with CVB3 by Phage ImmunoPrecipitation Sequencing (PhIP-Seq) and identified autoantibodies for several novel antigens not previously reported. The data were validated using enzyme-linked …

Non-Urgent Use Of Emergency Departments By Rural And Urban Adults, Erika Ziller Phd, Carly Milkowski, Zachariah Croll, Yvonne Jonk Phd

Access / Insurance

This study, conducted by researchers at the Maine Rural Health Research Center, provides updated information and addresses gaps in knowledge about rural non-urgent ED use. Understanding the rates of non-urgent ED use among rural adults and the factors associated with this use can inform policy and practice efforts to reduce unnecessary and inappropriate use of EDs in rural communities.

Hospital emergency departments (EDs) serve a vital role in the US health care system, providing lifesaving, around-the-clock care to patients in acute health situations. However, use of the ED for non-urgent care is costly and reflects a suboptimal care setting, with …

A Comparative Study Of A Non-Small Cell Lung Cancer Associated Egfr Missense Variant Of Uncertain Significance, Vanessa Mejia

Theses

Non-small cell lung cancer (NSCLC) is a form of lung cancer that can be driven by heightened activity of epidermal growth factor receptor encoded by the EGFR gene. Genetic variants in EGFR have been identified that lead to abnormal cell growth and tumorigenesis. The objectives of this study was to 1) determine if an EGFR variant of uncertain significance (VUS) associated with NSCLC is potentially damaging based on evaluation of the ortholog let-23 in the model organism, C. elegans, and 2) identify conserved missense VUS loci associated with NSCLC. Through ClinVar, the EGFR VUS c.845G>C(p.Gly282Ala) was identified in …

Impact Of Learning-Style-Based Education On Student Performance And Perception In Preclinical Endodontics: Part Ii, Rebecca Flaugher

Master's Theses (2009 -)

Objectives: This study aimed to investigate if providing supplemental learning materials aligned to students’ learning modes is equally beneficial among all modes both subjectively and objectively. Methods: IRB approval was obtained (Approval #HR-3746). Second-year dental students (n=92) enrolled in Preclinical Endodontics took Kolb Experiential Learning Profile (KELP) questionnaire to determine their learning mode: Abstract Conceptualization (AC), Active Experimentation (AE), Reflective Observation (RO), or Concrete Experience (CE). Students were assigned into groups corresponding to their learning mode. Students performed non-surgical root canal treatment (NSRCT) on a #9 typodont tooth and were graded to determine baseline performance (Project 1). Students were then …

Performance And Preference Of Rotary Files By Pre-Doctoral Dental Students At Marquette School Of Dentistry, Morgan Elizabeth Mccall

Master's Theses (2009 -)

Introduction: The aim of this study was twofold: 1) objectively evaluate root canal shaping and procedural mishaps using different NiTi rotary systems in the hands of unexperienced pre-doctoral dental students; 2) to gain an understanding of which rotary file system students subjectively prefer. Methods: Second year dental students (n=94) enrolled in preclinical endodontics received instructional videos and didactic lectures on the use of three different rotary filing systems: Vortex Blue, EndoSequence, and ProTaper Universal. Students completed root canal treatment using each file system on 3D printed premolars. The quantitative evaluation was completed after each project by two calibrated examiners using …

A Computational Fluid Dynamics Analysis Comparing Irrigation Within Complex Root Canal Anatomy, Madeleinne Fern

Master's Theses (2009 -)

Objectives: The aim of this study was to compare fluid dynamics in complex root canal systems shaped with minimally invasive versus progressively tapered file systems using single and double side-vented irrigation tips at different flowrates. Methods: Two identical, plastic mandibular molars were instrumented with minimally invasive and progressive file systems and scanned via micro-computed tomography. A computational fluid dynamics model was generated and enhanced with accessory canals and isthmus in the distal and mesial roots, respectively. The model replicated irrigation within complex canal anatomy using both a single and double side-vented, 30-gauge irrigation tip at four flowrates: 0.05, 0.10, 0.15 …

Sleeveless Guides Are More Accurate Than Sleeved Guides: An In Vitro Study, Jenna Hang

Master's Theses (2009 -)

BACKGROUND: Esthetic and functional results of an implant and its final prosthesis depend largely on the accuracy of implant placement. Fully-guided surgeries have been proven to be more accurate than non-guided implant placement. Surgical guides with metal keys are often used during guided surgery, but add tolerance to the guides. Sleeveless guides may improve accuracy of implant placement. OBJECTIVE: This study aims to examine the difference between surgical guides with (S) and without sleeves (SL) in terms of trueness and precision. A secondary aim was to assess the impact of the distance of the guide to the implant platform. METHODS: …

Preemptive Analgesia And Pain After Periodontal And Implant- Related Procedures: A Systematic Review And Meta-Analysis, Christos Gousias

Master's Theses (2009 -)

Objective: The purpose of this systematic review and meta-analysis is to document the effect of preemptive analgesia on patient-reported pain following periodontal and implant-related surgical procedures. Methods: A comprehensive search of the literature was conducted in PubMed, Cochrane, and Web of Science (PROSPERO ID: CRD42023471166). Randomized placebo-controlled clinical trials on adults undergoing periodontal and implant-related surgeries were included. A meta-analysis was performed comparing pain data at postoperative hours 1, 3, 6, 8, 24 and 72 between pre-emptive medication versus placebo groups. Results: Two independent reviewers screened 1,044 titles and included 15 studies (open flap debridement 6/12; flap and osseous surgery …

In Vitro Comparison Of Cellular Cytoxicity Of Conventional Vs. Cad/Cam Denture Base Materials, Zainab Hill Albasry

Master's Theses (2009 -)

Aim: Adverse reactions and local irritation of the oral mucosa to prostheses constructed from PMMA include allergic response, erythema, and a burning sensation of the tongue and mucosal tissues. Evidence on the cytotoxic effects of digitally manufactured denture base materials remains scarce. The aim of this study was to evaluate and compare the cytotoxic effects of CAD/CAM fabricated denture bases versus conventionally heat-cured acrylic resin materials. Materials and Methods: In total, 75 disks of five different denture resin materials – 15 disks per group were prepared: Ivocap (group 1; control), Ivotion denture base (group 2), Lucitone 3D denture base (group …