Medicine and Health Sciences Commons^™

Maternal Prebiotic Supplementation During Pregnancy And Lactation Modifies The Microbiome And Short Chain Fatty Acid Profile Of Both Mother And Infant, Jacquelyn M. Jones, Stacey N. Reinke, Mahsa Mousavi-Derazmahalleh, Johan Garssen, Maria C. Jenmalm, Ravisha Srinivasjois, Desiree Silva, Jeffrey Keelan, Susan L. Prescott, Debra J. Palmer, Claus T. Christophersen

Research outputs 2022 to 2026

Background & aims: Improving maternal gut health in pregnancy and lactation is a potential strategy to improve immune and metabolic health in offspring and curtail the rising rates of inflammatory diseases linked to alterations in gut microbiota. Here, we investigate the effects of a maternal prebiotic supplement (galacto-oligosaccharides and fructo-oligosaccharides), ingested daily from < 21 weeks' gestation to six months’ post-partum, in a double-blinded, randomised placebo-controlled trial. Methods: Stool samples were collected at multiple timepoints from 74 mother–infant pairs as part of a larger, double-blinded, randomised controlled allergy intervention trial. The participants were randomised to one of two groups; with one group receiving 14.2 g per day of prebiotic powder (galacto-oligosaccharides GOS and fructo-oligosaccharides FOS in ratio 9:1), and the other receiving a placebo powder consisting of 8.7 g per day of maltodextrin. The faecal microbiota of both mother and infants were assessed based on the analysis of bacterial 16S rRNA gene (V4 region) sequences, and short chain fatty acid (SCFA) concentrations in stool. Results: Significant differences in the maternal microbiota profiles between baseline and either 28-weeks’ or 36-weeks’ gestation were found in the prebiotic supplemented women. Infant microbial beta-diversity also significantly differed between prebiotic and placebo groups at 12-months of age. Supplementation was associated with increased abundance of commensal Bifidobacteria in the maternal microbiota, and a reduction in the abundance of Negativicutes in both maternal and infant microbiota. There were also changes in SCFA concentrations with maternal prebiotics supplementation, including significant differences in acetic acid concentration between intervention and control groups from 20 to 28-weeks’ gestation. Conclusion: Maternal prebiotic supplementation of 14.2 g per day GOS/FOS was found to favourably modify both the maternal and the developing infant gut microbiome. These results build on our understanding of the importance of maternal diet during pregnancy, and indicate that it is possible to intervene and modify the development of the infant microbiome by dietary modulation of the maternal gut microbiome.

Metabolite Signatures Associated With Microrna Mir-143-3p Serve As Drivers Of Poor Lung Function Trajectories In Childhood Asthma, Kevin M. Mendez, Sofina Begum, Anshul Tiwari, Rinku Sharma, Qingwen Chen, Rachel S. Kelly, Nicole Prince, Mengna Huang, Priyadarshini Kachroo, Su H. Chu, Yulu Chen, Kathleen Lee-Sarwar, David I. Broadhurst, Stacey N. Reinke, Robert Gerszten, Clary Clish, Lydiana Avila, Juan C. Celedón, Craig E. Wheelock, Scott T. Weiss, Michael Mcgeachie, Jessica A. Lasky-Su

Research outputs 2022 to 2026

Background: Lung function trajectories (LFTs) have been shown to be an important measure of long-term health in asthma. While there is a growing body of metabolomic studies on asthma status and other phenotypes, there are no prospective studies of the relationship between metabolomics and LFTs or their genomic determinants. Methods: We utilized ordinal logistic regression to identify plasma metabolite principal components associated with four previously-published LFTs in children from the Childhood Asthma Management Program (CAMP) (n = 660). The top significant metabolite principal component (PCLF) was evaluated in an independent cross-sectional child cohort, the Genetic Epidemiology of Asthma in Costa …

Supporting Cancer Survivors Following Treatment For Non-Hodgkin's And Hodgkin's Lymphoma: A Pilot Study Assessing The Feasibility And Process Outcomes Of A Nurse-Led Intervention, Amy J. Spooner, Jane Turner, Elise Button, Patsy Yates, Glen Kennedy, Jason Butler, Natalie Bradford, Alexandre Chan, Nicolas H. Hart, Raymond J. Chan

Research outputs 2022 to 2026

Objective: Lymphoma is the sixth most common cancer in Australia and comprises 2.8% of worldwide cancer diagnoses. Research targeting development and evaluation of post-treatment care for debilitating complications resulting from the disease and its treatment is limited. This study aimed to assess the feasibility and acceptability of a nurse-led survivorship intervention, post-treatment in Hodgkin's and non-Hodgkin's lymphoma survivors. Methods: A single-center, prospective, 3-arm, pilot, randomized controlled, parallel-group trial was used. People with lymphoma were recruited and randomized to the intervention (ENGAGE), education booklet only, or usual care arm. Participants receiving ENGAGE received an educational booklet and were offered 3 consultations …

2nd Place Contest Entry: Physician Visits For Patients With Diabetes By Gender, Age And Race In The United States, Daniel Umoru, Olajide Adekunle, Adeola Bakare

Eric M. Scandrett Graduate Library Research Prize

This is Daniel Umoru, Olajide Adekunle, and Adeola Bakare's submission for the 2024 Eric M. Scandrett Graduate Research Prize, which won second place. It contains their essay on using library resources, their bibliography, and a summary of their research project (with Dr. Lawrence "LB" Brown) on the complex demographic landscape of diabetes prevalence in the United States.

Daniel, Adeola, and Olajide are doctoral students in the School of Pharmacy at Chapman University. Their faculty mentor is Dr. Enrique Seoane-Vazquez.

Exploring Caregiver Support For Advanced Practice Nurses Following An Error, Sunnie L. Nield

Student Works

Advanced Practice Registered Nurses (APRN) are a growing population of employed individuals within the healthcare system, working in outpatient and inpatient settings. Like other healthcare professionals, nurse practitioners can and do make errors while practicing. Nevertheless, little to no research has focused on them. This research aimed to better understand nurse practitioners’ attitudes towards error approach, perception, and cause using the Medical Error Attitude Scale (MEAS). Additional purposes included the further exploration of APRNs' experiences following an error and support they may or may not receive. A convenience sample of ARPNs licensed in Utah was sent an electronic survey via …

Incidental Actinomycosis In A 44-Year-Old Female During Total Abdominal Hysterectomy For Abnormal Uterine Bleeding: A Case Report, Willbroad Kyejo, Allyzain Ismail, Abduel Kitua, Brenda Moshi, Gregory Ntiyakunze, Munawar Kaguta, Ally Mwanga

Internal Medicine, East Africa

Actinomycosis, a rare chronic bacterial infection caused by Actinomyces species, presents diagnostic challenges due to diverse clinical presentations. This report presents a case of peritoneal actinomycosis incidentally discovered during a total abdominal hysterectomy in a 44-year-old female with refractory abnormal uterine bleeding and a history of long-term intrauterine contraceptive device use. The patient presented with persistent abnormal uterine bleeding despite conservative management. Intraoperative findings during total abdominal hysterectomy revealed peritoneal involvement, prompting histopathological evaluation confirming actinomycosis. This case highlights diagnostic complexities associated with actinomycosis, emphasizing the significance of histopathological confirmation. Postoperative management with antibiotics demonstrated favorable outcomes, supporting their efficacy …

Acute Coronary Syndrome Patterns In The Young: Risk Factor Profile And In-Hospital Outcomes In A Tertiary Referral Hospital In Kenya, Nadeem Kassam, Mzee Ngunga, Mohamed Varwani, Miriam Msunza, Jeilan Mohamed

Internal Medicine, East Africa

Introduction: Acute coronary syndrome (ACS) accounts for coronary artery disease (CAD) –related morbidity and mortality. There has been growing concern about the rising incidence of ACS among young individuals globally both in developed and developing countries, including Sub-Saharan Africa. This group’s phenotypic characteristics; risk factors and clinical outcomes are not well described. contextual and regional studies are necessary to understand the magnitude of ACS among young Individuals and help highlight challenges and opportunities for improved ACS outcomes in the region. The study aimed to describe the demographic and clinical characteristics of young individuals hospitalized with ACS and report on in-hospital …

Incidental Actinomycosis In A 44-Year-Old Female During Total Abdominal Hysterectomy For Abnormal Uterine Bleeding: A Case Report, Willbroad Kyejo, Ally Zain Ismail, Abduel Kitua, Gregory Ntiyakunze, Munawar Kaguta, Ally Mwawnga

Family Medicine, East Africa

Actinomycosis, a rare chronic bacterial infection caused by Actinomyces species, presents diagnostic challenges due to diverse clinical presentations. This report presents a case of peritoneal actinomycosis incidentally discovered during a total abdominal hysterectomy in a 44-year-old female with refractory abnormal uterine bleeding and a history of long-term intrauterine contraceptive device use. The patient presented with persistent abnormal uterine bleeding despite conservative management. Intraoperative findings during total abdominal hysterectomy revealed peritoneal involvement, prompting histopathological evaluation confirming actinomycosis. This case highlights diagnostic complexities associated with actinomycosis, emphasizing the significance of histopathological confirmation. Postoperative management with antibiotics demonstrated favorable outcomes, supporting their efficacy …

Novel Methods Of Identifying Individual And Neighborhood Risk Factors For Loss To Follow-Up After Ophthalmic Screening, Noah Heilenbach, Titilola Ogunsola, Ceyhun Elgin, Dustin Fry, Mina Iskander, Yara Abazah, Ahmed Aboseria, Rahm Alshamah, Jad Alshamah, Gladys Maestre

School of Medicine Publications

Précis

Residence in a middle-class neighborhood correlated with lower follow-up compared to residence in more affluent neighborhoods. The most common explanations for not following up were the process of making an appointment and lack of symptoms.

Purpose:

To explore which individual and neighborhood-level factors influence follow-up as recommended after positive ophthalmic and primary care screening in a vulnerable population using novel methodologies.

Participants

and Methods: From 2017 to 2018, 957 participants were screened for ophthalmic disease and cardiovascular risk factors as part of the Real-Time Mobile Teleophthalmology study. Individuals who screened positive for either ophthalmic or cardiovascular risk factors were …

Sleep Apnea And Ischemic Stroke- A Perspective For Translational Preclinical Modelling, Ifechukwude J. Biose, A B. Bakare, H Wang, T E. Gressett, G J. Bix

School of Medicine Faculty Publications

Obstructive sleep apnea (OSA) is associated with ischemic stroke. There is, however, a lack of knowledge on the exact cause-effect relationship, and preclinical models of OSA for experimental ischemic stroke investigations are not well characterized. In this review, we discuss sleep apnea and its relationship with stroke risk factors. We consider how OSA may lead to ischemic stroke and how OSA-induced metabolic syndrome and hypothalamic-pituitary axis (HPA) dysfunction could serve as therapeutic targets to prevent ischemic stroke. Further, we examine the translational potential of established preclinical models of OSA. We conclude that metabolic syndrome and HPA dysfunction, which are often …

Sepsis Is Serious. Recognize The Signs, Stuart L. Segelnick Dds, Ms, Cde

The New York State Dental Journal

Untreated or poorly managed periodontal disease, caries, endodontic and dental alveolar lesions can lead to sepsis. Case reports published in dental literature highlight the morbidity and mortality of dental disease complications.

Public Health Emergency Management For Interprofessional Learners: Development Of A Curriculum, Terry D. Cooper

Health Science Doctoral Thesis

In our world, hazards and disasters are becoming more frequent and destructive. The impacts that disasters have on physical, mental, and environmental health are substantial and can be devastating. Responding to and recovering from disasters with increasing complexities requires interdisciplinary teams with the knowledge, skills, and attitudes that transcend several fields. This thesis aims to investigate the essential educational factors of interprofessional education (IPE) to inform the development of an effective curriculum that implements IPE for education in public health emergency management (PHEM). The thesis was supported by a quantitative survey with open-ended questions. Curriculum development followed the Kern 6-step …

Exploring Barriers To Recruitment And Retention In Cancer Clinical Trials Among Underrepresented Populations: Perspectives Of Clinical Trial Research Coordinating Staff, Sumbul Yousafi

Health Science Doctoral Thesis

Background: Clinical trials are crucial in advancing scientific knowledge and interventions and exploring more efficient and safe treatments to improve patient care and health outcomes. The active participation of patients and researchers has made it feasible to conduct clinical trials that have been ground-breaking and become the standardized practice of care; however, the participation of underrepresented populations in clinical trials has been identified to be low. This issue can impact the generalizability of findings from clinical trials and efforts to promote health equity. Appropriate representation from underrepresented populations in clinical trials is vital; it will contribute to equitable healthcare for …

2024 Spring Newsletter, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2024 Spring Newsletter of the Department of Nursing at Morehead State University.

Ovarian Torsion, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

A Quality Improvement Project To Promote Awareness And Knowledge Of Nutrition As An Adjunctive Treatment Option For Chronic Insomnia, Sara J. Weelborg

Doctor of Nursing Practice Projects

Background

Insomnia is difficult to treat resulting in adverse outcomes. Traditional treatments are not always safe or accessible. Evidence, not readily available to providers, supports the adjunctive use of nutrition to ease symptoms.

Problem

Literature recommends the Mediterranean Diet for insomnia. A nutrition education module for psychiatric nurse practitioners (n=4) was created by a multidisciplinary committee to increase knowledge and comfort. Pre-post Likert-scale tool, multiple choice test, and interview questions were used to measure educational benefits.

Outcomes

All participants demonstrated knowledge acquisition (range 11% to 100%), increased intention to use information (range 9% to 43%), and positive feedback about nutrition …

Longitudinal Evaluation Of Vitamin D Concentrations In Relation To The Onset Of Type 2 Diabetes In American Adults: A Secondary Data Analysis, Kathryn Michelle Schurr

Dissertations

Background: Prior research has suggested that low levels of Vitamin D may have negative effects on various biological functions, including Type 2 diabetes. The relationship between Vitamin D and the risk of Type 2 Diabetes has not yet been fully investigated. The objective of this research is to examine patients’ laboratory test data longitudinally to determine how vitamin D and other covariates of interest affect Type 2 diabetes status over time.

Methods: This study used retrospective data review from Quest Diagnostics from January 1, 2010, through December 31, 2022. Patients included in the study were required to have consecutive test …

The Effects Of Covid-19 Stressors And Supervisor Support On Emotional Exhaustion And Work Engagement, Meiqiao Gu

Psychology Theses & Dissertations

Since the onset of the COVID-19 pandemic, working conditions have worsened, subjecting employees to numerous stressors. Analyzing the impact of COVID-19 stressors on employees‘ well-being and work motivation is crucial. The job demands-resources model (JD-R; Demerouti et al., 2001a) provides a framework for evaluating how COVID-19 stressors affect employees‘ well-being and motivation in the workplace. Given the complexity of job characteristics during the COVID-19 pandemic, coupled with challenges in obtaining adequate support from supervisors who are also facing considerable work pressure, this study examines the continued relevance of the JD-R model in this evolving work environment. Specifically, four hypotheses were …

Effects Of Balance Training On Spinal Reflexive Excitability Modulation, Corticospinal Excitability, And Balance Performance In Individuals With Chronic Ankle Instability, Sunghoon Chung

Rehabilitation Sciences Theses & Dissertations

Chronic ankle instability (CAI) is a neurophysiologic deficit resulting in diverse sensorimotor impairments. Following acute ankle sprains, pain, mechanical instability, and joint deafferentation reduce sensory input to the central nervous system (CNS). In response, the CNS sends altered motor signals to lower extremity muscles. These CNS changes contribute to various neuromuscular impairments in CAI patients, the most common of which is reduced balance performance. Specifically, CAI patients struggle to modulate spinal reflex excitability of the soleus muscle when progressing from simpler to more complex balance tasks. This overreliance on spinal reflexes results in inconsistent activation of the ankle stabilizing muscle. …

Wellness As A Predictor Of Turnover Intention In The Active Duty Military, Thomas Clifford Seguin

Counseling & Human Services Theses & Dissertations

Due to the unique nature of military service compared to civilian professions, military attrition is difficult to predict using methods derived from career development theories, so turnover remains an ongoing concern for the active duty military. For this reason, military attrition, through turnover intention, should be investigated through a novel lens with the intention of capturing an essence of military service which previous methods may have overlooked, namely the holistic construct of perceived wellness. Previous studies have shown how wellness-related factors affect turnover intention, but none has studied the relationship between perceived wellness and turnover intention. The main hypothesis of …

Supervision Needs Of Novice Behavioral Health Providers In Integrated Primary Care Settings: A Delphi Study, Nicholas D. Schmoyer

Counseling & Human Services Theses & Dissertations

The integration of behavioral health providers (BHPs, i.e., clinical mental health counselors, clinical psychologists, clinical social workers, marriage and family therapists) into primary care settings has developed as a healthcare practice associated with enhanced patient clinical outcomes, enhanced patient satisfaction, reduced healthcare expenditures, and enhanced provider wellness and satisfaction, known together as the Quadruple Aim. For BHPs practicing in integrated primary care (IPC) settings, researchers have highlighted a variety of challenges they experience when integrating in these settings, with a consistent challenge being a lack of satisfactory training and supervision. Clinical supervision has been hailed as the “signature pedagogy” for …

Shaping The Future Of Vascular Care: The Evolution Of Advanced Practice Providers (Apps)., Alexandra Moran Baird, Katherine Hays, Danielle Vlazny

Medical Education Articles

No abstract provided.

Transitioning From Afmrd Entrustable Professional Activities To Abfm Core Outcomes To Measure Clinical Preparedness., Bryce A Ringwald

Medical Education Articles

No abstract provided.

Learning To Lead: The Evolution Of A Pilot Leadership Curriculum For Gynecologic Oncology Fellows At The Ohio State University., Monica D Levine, Vincent M Wagner, Courtney J Riedinger, Wafa Khadraoui, Paulina J Haight, Molly Morton, David A Barrington, Corinne A Calo, Antonio V Castaneda, Michelle Lightfoot, Julia Chalif, Anna Gonzalez, David E Cohn

Medical Education Articles

•Leadership training is under-emphasized in traditional medical education.•An effective leadership curriculum must be dynamic and requires genuine investment from participants.•Through didactic education, self-reflection, and real-world perspective we can actively mold future leaders in gynecologic oncology.

Heel Warmer Effectiveness, Karina Collazo-Lopez Bsn, Rn, Amber Guzman Adn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Fall Prevention, Amy M, Nika Crisostomo, Amanda V, Taniyah Preux

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Shsp Dean's Newsletter, Spring 2024, Robert W. Amler

SHSP Dean’s Newsletter

No abstract provided.

Waring Library Society Newsletter, Spring 2024, Waring Library Society, Waring Historical Library, Medical University Of South Carolina, Anna Marie Schuldt, Robert Ball, Joann Livingston Zeise, Tabitha Samuel, Kathryn Glorioso

The Waring Library Society Newsletters

The Spring 2024 issue of the Waring Library Society Newsletter is available now. In this issue, Waring Library Society President Dr. Robert Ball gives his first remarks as WLS President for the newsletter; JoAnn Zeise discusses Louis R. Agassiz’s time at the Medical College in 1849; Tabitha Samuel announces the new additions to MEDICA@MUSC; and Kathryn Glorioso provides insight into one MUSC lab intersection with history and Francis Peyre Porcher.

Exploring The Use Of Trauma-Informed Care Practices In Extension, Caitlin O'Brien, Martie Gillen

Journal of Human Sciences and Extension

A content analysis of 63 land-grant Extension university websites was conducted to examine the promotion of trauma-informed care (TIC) through the sharing of resources, providing instructive webinars and/or in-person events, and offering comprehensive programs. While many Extension universities are sharing resources, only nine universities (14%) featured robust TIC Extension programs, and 40% shared no TIC information. Additionally, we found no indication of internal education programs across the universities on adverse childhood experiences (ACEs) and TIC practices for Extension faculty and staff. These findings highlight opportunities to increase efforts with the public as well as internally within Extension.

Improving Provider Ordered Annual Breast Cancer Screening In Primary Care, Alexis Manzella

DNP Projects

Significance and Background: Breast cancer is the most common cancer in women throughout the United States. Specifically, the state of Connecticut has one of the highest rates of breast cancer in the country. Multiple evidence-based organizations have developed specific guidelines for screening in clinical practice. These guidelines specify when a woman should be screened and how frequently. A project was put in place at a FQHC in Connecticut to increase the number of breast cancer screenings ordered, based on clinical guidelines. Evidence supported the use of provider education to increase the number of mammograms ordered (Marks,2022).

Purpose: Increase the number …