Medicine and Health Sciences Commons^™

Cardiometabolic Characteristics Of People With Metabolically Healthy And Unhealthy Obesity, Max C Petersen, Gordon I Smith, Hector H Palacios, Sarah S Farabi, Mihoko Yoshino, Jun Yoshino, Kevin Cho, Victor G Davila-Roman, Ruteja A Barve, Jinsheng Yu, Jennifer H Stern, Bruce W Patterson, Gary J Patti, Samuel Klein, Et Al.

2020-Current year OA Pubs

There is considerable heterogeneity in the cardiometabolic abnormalities associated with obesity. We evaluated multi-organ system metabolic function in 20 adults with metabolically healthy obesity (MHO; normal fasting glucose and triglycerides, oral glucose tolerance, intrahepatic triglyceride content, and whole-body insulin sensitivity), 20 adults with metabolically unhealthy obesity (MUO; prediabetes, hepatic steatosis, and whole-body insulin resistance), and 15 adults who were metabolically healthy lean. Compared with MUO, people with MHO had (1) altered skeletal muscle biology (decreased ceramide content and increased expression of genes involved in BCAA catabolism and mitochondrial structure/function); (2) altered adipose tissue biology (decreased expression of genes involved in …

A Compendium Of Multi-Omics Data Illuminating Host Responses To Lethal Human Virus Infections, Amie J Eisfeld, Larissa B Thackray, Qing Tan, Michael S Diamond, Et Al.

2020-Current year OA Pubs

Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death. Here, we present experimental methods and multi-omics data capture approaches representing the global host response to infection generated from 45 individual experiments involving human viruses from the Orthomyxoviridae, Filoviridae, Flaviviridae, and Coronaviridae families. Analogous experimental designs were implemented across human or mouse host model systems, longitudinal samples were collected over defined time courses, and global multi-omics data (transcriptomics, proteomics, metabolomics, and lipidomics) were acquired by microarray, RNA sequencing, or mass spectrometry analyses. For …

Environmental And Sociocultural Factors Are Associated With Pain-Related Brain Structure Among Diverse Individuals With Chronic Musculoskeletal Pain: Intersectional Considerations, Lisa H Domenico, Jared J Tanner, Angela M Mickle, Ellen L Terry, Cynthia Garvan, Song Lai, Hrishikesh Deshpande, Roland Staud, David Redden, Catherine C Price, Burel R Goodin, Roger B Fillingim, Kimberly T Sibille

2020-Current year OA Pubs

Chronic musculoskeletal pain including knee osteoarthritis (OA) is a leading cause of disability worldwide. Previous research indicates ethnic-race groups differ in the pain and functional limitations experienced with knee OA. However, when socioenvironmental factors are included in analyses, group differences in pain and function wane. Pain-related brain structures are another area where ethnic-race group differences have been observed. Environmental and sociocultural factors e.g., income, education, experiences of discrimination, and social support influence brain structures. We investigate if environmental and sociocultural factors reduce previously observed ethnic-race group differences in pain-related brain structures. Data were analyzed from 147 self-identified non-Hispanic black (NHB) …

Health Factors Associated With Development And Severity Of Poststroke Dysphagia: An Epidemiological Investigation, Brittany N Krekeler, Opeolu Adeoye, Et Al.

2020-Current year OA Pubs

BACKGROUND: Dysphagia after stroke is common and can impact morbidity and death. The purpose of this population-based study was to determine specific epidemiological and health risk factors that impact development of dysphagia after acute stroke.

METHODS AND RESULTS: Ischemic and hemorrhagic stroke cases from 2010 and 2015 were identified via chart review from the GCNKSS (Greater Cincinnati Northern Kentucky Stroke Study), a representative sample of ≈1.3 million adults from southwestern Ohio and northern Kentucky. Dysphagia status was determined on the basis of clinical assessments and necessity for alternative access to nutrition via nasogastric or percutaneous endoscopic gastrostomy tube placement. Comparisons …

In Silico Identification Of Small Molecule Agonist Binding Sites On Kcc2, Kenyon Mitchell, Alfred Amendolara, Ruth Hunter, Jaden Miner, Andrew Payne

Annual Research Symposium

Purpose: Potassium-Chloride Cotransporter 2 (KCC2) is a neuronal membrane protein specific to the central nervous system. It is responsible for removing Cl- ions from the intracellular space, maintaining a normal Cl- gradient essential for proper function at inhibitory synapses. Dysregulation causes an upward shift in the Cl- reversal potential resulting in a hyperexcitable state of the postsynaptic neuron. Existing literature indicates that KCC2 may be involved in the addiction pathway of a variety of drugs of abuse, including opioids and alcohol. This makes KCC2 an attractive potential drug target when treating substance use disorders. A novel direct KCC2 agonist, VU0500469, …

A Systematic Review: Mirror Neurons & Schizophrenia, Yashesvi Sharma, Surajit Dey

Annual Research Symposium

This research project establishes a link between Mirror Neuron System (MNS) activity and this information's implications in treating and understanding schizophrenia, specifically, schizophrenic patients with negative symptoms.

Benefits Of The Use Of Probiotics In Preventing Secondary Infections, Sarah Cutcher

Scholars Week

Through evidence based research, the use of supplemental probiotics has been shown to have a positive effect in preventing secondary infections in hospital patients. Although there are other techniques that have decreased the incidence of infections, such as reducing invasive procedures and aseptic techniques, these are external procedures designed to prevent infection. Probiotics are an effective method of internally preventing infection. By studying certain infections and the effect that probiotics have on their prevention, researchers can safely conclude which bacteria strain could help to prevent each infection. Some different types of issues that will be looked at are healthcare acquired …

The Impact Of Spirituality On Patient Outcomes And How Nurses Can Implement Spirituality In Patient Care, Audrey Pittman

Scholars Week

This article studied the impact of spirituality on patient outcomes and how nurses can implement spirituality into patient care. This study looked at peer reviewed articles over the impact of spirituality on patient care. They found a positive impact of spiritual wellness and patient outcomes. Next it looked at how nurses could implement spiritual care into practice. This study found that the implementation of the FICA assessment tool would be a great first step in the right direction on no longer neglecting spiritual wellness.

Implementing Intermittent Fetal Monitoring In Low-Risk Laboring Moms, Kaitlynn Keel, Jessica Manion

Scholars Week

It has become common practice for laboring moms to remain attached to monitors throughout the duration of their labor, known as continuous electronic fetal monitoring (CEFM). Although this is the new normal in the world of labor and delivery, there has been speculation as to whether or not this is evidence-based. Specifically, moms in labor that are considered low-risk should not be bound to the bed for their entire labor for this continuous monitoring, in fact, research actually supports that CEFM leads to unnecessary interventions that negatively impact both mom and neonate.

Emphasizing The Importance Of Clustering Care For Newborns In The Nicu Setting, Callie Hines Sn, Alyssa Howell Sn, Elizabeth Crews Sn

Scholars Week

For our Evidence-Based Project, we have chosen to cover the topic concerning clustering care for premature infants in the neonatal intensive care unit. In many NICU's across the country preterm infants are taken care of on an as needed basis. Research and Swanson’s theory of caring supports that clustering care has a positive correlation with the improvement of vital signs, physical and intellectual development, and infection control.

Debriefing After A High Stakes Situation ​, Austin Hildebrant, Noah Merriss, Brennon Hamm

Scholars Week

This powerpoint presentation details the importance of debriefing after a high stakes situation in the hospital setting.

Fire Safety In The Or, Raghda Abo Al Haija, Leah Cullop, Keeli Mckeel

Scholars Week

Fire safety in the operating room (OR) is crucial, and so it is important for the OR team to be aware of practices that help prevent and manage operating room fires. This presentation compiles evidence-based research on practices and interventions that promote OR fire safety.

Local Anesthetic Systemic Toxicity (Last): Provider Education, Alexis Johnson

Scholars Week

Abstract

Background: Local Anesthetic Systemic Toxicity (LAST) is a rare but serious complication due to accumulation of local anesthetics. If not treated quickly, LAST can cause detrimental complications such as seizures and cardiac arrest. Therefore, it is important that anesthesia providers are well versed in preventing, recognizing, and treating this adverse event.

Methods: A LAST flowchart written by The American Society of Regional Anesthesia and Pain Medicine (ASRA) was printed and placed in each operating room in a small suburban hospital. Anesthesia staff were also educated on recognizing signs and symptoms, onset time, high risk patients, and prevention.

Results: Ten …

Reducing Perioperative Opioid Use Through Utilization Of Dexmedetomidine Prior To Induction: Provider Education, Axel Nilsson

Scholars Week

Reducing Perioperative Opioid Use Through Utilization of Dexmedetomidine

Prior to Induction: Provider Education

Abstract

AIM: The primary objective of this project was to decrease perioperative opioid use by providing education to key stakeholders on the efficacy of implementing dexmedetomidine prior to induction to attenuate the response to surgical stress.

KEYWORDS: anesthesia, dexmedetomidine, opioid-sparing analgesia, multimodal analgesia

METHODS: Strategies to promote a practice change included disseminating education to anesthesia providers through handouts and one-on-one education and evaluating the efficacy of the education through questionnaires.

RESULTS: Twelve anesthesia providers participated in the project. After receiving education, the mean score based on a …

Improving Anesthesia Handoff: Implementing Standardized Handoff Tool For Post-Open-Heart Surgery In Critical Care Settings, Kelly Doyle

Scholars Week

The purpose of this project was to create a handoff tool implemented post-operatively by anesthesia providers during every transfer of care with patients undergoing open heart surgery and transitioning to the intensive care unit. Communication errors have been identified as a primary cause of anesthesia-related sentinel events, particularly during patient handoff, which can lead to negative patient outcomes due to incomplete relay of information. This Quality Improvement Project was conducted at a single facility where Certified Registered Nurse Anesthetists, (CRNAs) incorporated a handoff tool into their anesthesia handoff following coronary artery bypass graft surgery over a six-week period. Both pre- …

Education Of Ventilator-Associated Pneumonia Prevention In Adult Intensive Care Patients, Carlin Morgan

Scholars Week

The purpose of this project was to improve knowledge related to evidence-based ventilator-associated pneumonia (VAP) preventative measures that decrease the prevalence of VAP in adult patients in the intensive care unit (ICU). An educational presentation was provided to twelve critical care nurses at a 349-bed hospital in western Kentucky. A pretest was obtained to measure the nurse’s knowledge prior to the presentation. A PowerPoint and pamphlet containing VAP prevention techniques were presented to the twelve critical care nurses during each meeting. A posttest was then administered after the presentation to measure the efficacy of the educational presentation. The mean of …

Overcoming Barriers Associated With Inequitable Historic Highway Development Dcisions: New Orleans Interstate-10 (I-10), Christina Quijano, Amy Stelly, Adrienne Katner

School of Public Health Delta Omega Honors Day Poster Sessions

Background: Gentrification has become growing concern in many cities across the United States. Post Hurricane Katrina, New Orleans has seen an influx in gentrification, the Treme Neighborhood being one of them. With future plans to remove the Claiborne Avenue I-10 Corridor, increased gentrification in Treme has become a concern of the residents. Case Description: Gentrification-associated policies implemented by other states and cities were evaluated to assess feasibility to adoption in New Orleans. Two solutions were identified as presenting the greatest benefit and least impact on stakeholders. The creation of a community land trust and development of an anti-displacement policy is …

Trend Of Louisiana Covid-19 Outbreaks In Religious Services: March 2020 - February 2021, Julius L. Tonzel, Theresa Sokol, Susanne Straif-Bourgeois

School of Public Health Delta Omega Honors Day Poster Sessions

Objective: To better understand the impact of the transmission of COVID-19 in religious services in Louisiana. Background: Louisiana identified its first COVID-19 outbreak in a religious service, or place of worship for faith-based communities, in March 2020. As a mitigation response, during the Phase 1 period, maximum capacity was reduced to 25% and masking and social distancing were enforced. As religious services return to maximum capacity, there is concern about the role that these settings will contribute to the burden of disease. Methods: COVID-19 outbreaks in religious services were identified by the Louisiana Office of Public Health Infectious Disease Epidemiology …

Perceptions Of Manual Vacuum Aspiration Among Resident And Atending Physicians In Louisiana, Kelly Chau, Mirandy Li, Jennifer Robinson, Stacey Scheib

School of Public Health Delta Omega Honors Day Poster Sessions

Background: Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ) individuals are more likely to smoke than non-LGBTQ individuals, and there is currently a heavy need for smoking cessation research for LGBTQ populations. Smoking has been posited as a coping mechanism for LGBTQ individuals facing minority stress. However, no studies have examined the exact effect that minority stress has on smoking in LGBTQ populations. Therefore, the purpose of this systematic review is to examine which minority stress processes effect smoking behaviors for LGBTQ individuals. Methods: PubMed, EBSCO, and PsychInfo searches were conducted for smoking-, LGBTQ-, and minority stress-related terms. No date, geographic, …

A Phase 1 Clinical Trial Combining Car T-Cell Therapy With Autologous Hematopoietic Stem Cells In A Multi-Cultural Patient Population, Bry Reinhardt Ms

School of Public Health Delta Omega Honors Day Poster Sessions

Background: Chimeric Antigen Receptor (CAR) T-Cell therapy is a type of immunotherapy designed to treat relapsed/refractory hematologic malignancies such non-Hodgkin B-Cell Lymphoma, B-Cell Acute Lymphoblastic Leukemia, and Multiple Myeloma. CAR T toxicities such as cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome and post-infusion cytopenias pose major challenges to the regimen. Additionally, CAR T is a complicated and involved therapy. It is critical to explain the risks and benefits to patients, which can be challenging when they are non-native English speakers.

Objectives: The co-primary endpoints of this trial are to determine the feasibility of collecting the target cell dose of …

Assessing Stigma In People Living With Hiv, Kyle Mistretta, John W. Apolzan, Hui-Yi Lin, Connie Arnold, Jonathan R. Schroeder, David Welsh, Lauren E. Richey

School of Public Health Delta Omega Honors Day Poster Sessions

Abstract: Stigma and discrimination may result in poorer health literacy, negative health outcomes, and increased morbidity from other chronic diseases in PWH. We created a multidisciplinary team to study stigma, health behaviors, and outcomes in PWH in Louisiana. The team HIV clinics in three cities; New Orleans, Baton Rouge, and Shreveport, forming the Louisiana Translational Collaborative on Health Behaviors [LATCH]. We hypothesized that PWH who report increased stigma would have lower health literacy and more comorbidities.

Methods: PWH aged ≥ 18 were recruited from three HIV clinics during regular appointments. Participants completed standardized surveys that assessed stigma via the HIV …

Eat, Sleep, Console, Claire Hauke, Grace Hauke

Scholars Week

Eat, Sleep, Console is a scale used to assess opioid withdrawing neonates. This scale focuses on infant function and comfort, rather than treating infants based on signs and symptoms of withdrawal alone.

Optimizing Digital Proficiency To Improve Perceived Self-Efficacy In Telehealth Nurses, Serena Young

Doctor of Nursing Practice Projects

The use of telehealth to provide care management services has increased as healthcare continues to evolve. Seven million Americans were predicted to use telehealth in 2020, which increased to over 35 million through the pandemic. These services have been shown to decrease healthcare disparities and promote positive health outcomes. Education and training for nurses providing telehealth services have not kept up with the increased demand. Nurses providing care management telehealth services in a large tertiary health system have low perceived self-efficacy for technology. Leaders in the organization believe this is causing a lack of digital proficiency in their workforce. This …

Implementation Of An Advanced Practice Provider Fellowship To Improve Transition To Practice, Breanne Hosford

Doctor of Nursing Practice Projects

Problem

Retention of advanced practice providers (APPs) is needed for ongoing high quality comprehensive care. Administrators at a large urban pediatric institute in the Midwest identified turnover and retention as an issue for APPs in the first one to two years of service. Even in years when turnover rates were not as high, the greatest number of APPs leaving the institution where those in their first five years of tenure. Without strategies aimed at improving transition to practice, new hire APPs will continue to be unprepared for their new role, therefore endangering job satisfaction, leading to continued turnover, and threatening …

A Patient Centered Quality Improvement Education Program Designed To Improve The Health Of Patients Living With Uncontrolled Hypertension In A Primary Care Setting, Alia Jamison-Dinowitz

Doctor of Nursing Practice Projects

Cardiovascular disease is the leading cause of death in the United States and it negatively contributes to poor health outcomes (Martinez-Garcia et al., 2018). Within the Antelope Valley in Lancaster California, 30.3 % of city residents have a hypertension diagnosis (Los Angeles County of Public Health, 2017). Much like the city at large, hypertension is a critical issue at AV Pediatrics and Family Medicine (AV Peds). This issue is driven by a variety of factors including a lack of understanding about hypertension and medication compliance, and a lack of understanding about healthy lifestyle choices. Providers at AV Peds have seen …

Occupational Impacts Of Seizures, Stephanie Nailon, Karen Park, Kelly Rodenkirch

Spring 2024 Virtual OTD Capstone Symposium

This research looks at the occupational impacts of seizure disorders on the adolescent population. The research study explores how their condition impacts the adolescent and family unit. The research was gathered from multiple perspectives to gain an in-depth understanding to best aid occupational therapists and health care professionals to gain a deeper understanding of areas to address when working with this population.

Development Of A Novel Humanized Anti-Tslp Monoclonal Antibody Hz-1127 With Anti-Allergic Diseases And Cancer Potential., Xiaolei Liu, Jianzhong Han, Qian Wang, Peng Wang, Li Li, Kehe Du, Fengchao Jiang, Pei Zhang, Hongjun Liu, Jian Huang

Cooper Medical School of Rowan University Departmental Research

Thymic stromal lymphopoietin (TSLP) is a member of the IL-2 cytokine family and has been widely recognized as a master regulator of type 2 inflammatory responses at barrier surfaces. Recent studies found dysregulation of the TSLP-TSLP receptor (TSLPR) pathway is associated with the pathogenesis of not only allergic diseases but also a wide variety of cancers including both solid tumors and hematological tumors. Thus, the blockade of TSLP represents an attractive therapeutic strategy for allergic diseases and cancer. In this study, we report the development of a novel humanized anti-TSLP monoclonal antibody (mAb) HZ-1127. Binding affinity, specificity, and ability of …

Voices, Stories And Experiences Of Black Women Phase Ii: Community Engagement Activity Report Informing The Establishment Of A Trenton-Based Maternal & Infant Health Innovation Center, John S. Watson Institute For Urban Policy And Research, Tirzah Spencer, Phd, Mph, Barbara George Johnson

Center for Urban Policy Research

As an extension of our 2022 study Voices, Stories and Experiences of Black Women (Phase 1), the John S. Watson Institute for Urban Policy and Research at Kean University’s Maternal and Child Health Equity Team was asked to share information about the planned Maternal and Infant Health Innovation Center (MIHIC) with Trenton residents as a part of Nurture NJ’s community engagement efforts. The Team implemented the following community engagement activities: Communication: Community engagement through social media outreach and in-person outreach were used as approaches to inform Trenton residents about the MIHIC. Dissemination of Findings: Community cafés were designed to share …

Abortion: Analysis Of The Bioethical And Metaphysical Standpoint, Lauren Kovarick

Richard T. Schellhase Essay Prize in Ethics

The antagonistic relationship between a mother and their unborn child creates the controversial topic of abortion. With massive moral implications and consequences associated, education on the laws and reasoning is significant to determine the direction of society. To analyze the ethics of abortion, the bioethical and metaphysical debate must be considered. With the former, the four principles of bioethics are used in healthcare practice to break down an ethical concern. On the metaphysical side, the life-status and rights of the fetus are acknowledged. With this topic, it is important not to argue in favor of one position, but instead have …

Returning To Sexual Activity And Intimacy After Spinal Cord Injury, Hanna Bush

Occupational Therapy Doctoral Student Capstone Posters

Sexual activity and intimacy are meaningful occupations for many individuals, regardless of ability. According to the OTPF-4, sexual activity and intimacy are activities of daily living. It is also a right for persons to have access to engage in meaningful activities. However, there is significant information reported that individuals with spinal cord injuries are not receiving sufficient, or any, information for returning to sexual activity during occupational therapy treatment. A program manual, educational materials, and handouts were designed for those with spinal cord injuries seeking to return to the ADL of sexual activity and intimacy upon discharge from inpatient rehabilitation.