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Articles 54391 - 54420 of 325297

Full-Text Articles in Medicine and Health Sciences

Pathological Response In Resectable Non-Small Cell Lung Cancer: A Systematic Literature Review And Meta-Analysis, Nathalie A Waser, Melanie Quintana, Bernd Schweikert, Jamie E Chaft, Lindsay Berry, Ahmed Adam, Lien Vo, John R Penrod, Joseph Fiore, Donald A Berry, Sarah Goring Apr 2024

Pathological Response In Resectable Non-Small Cell Lung Cancer: A Systematic Literature Review And Meta-Analysis, Nathalie A Waser, Melanie Quintana, Bernd Schweikert, Jamie E Chaft, Lindsay Berry, Ahmed Adam, Lien Vo, John R Penrod, Joseph Fiore, Donald A Berry, Sarah Goring

Faculty, Staff and Student Publications

BACKGROUND: Surrogate endpoints for overall survival in patients with resectable non-small cell lung cancer receiving neoadjuvant therapy are needed to provide earlier treatment outcome indicators and accelerate drug approval. This study's main objectives were to investigate the association among pathological complete response, major pathological response, event-free survival and overall survival and to determine whether treatment effects on pathological complete response and event-free survival correlate with treatment effects on overall survival.

METHODS: A comprehensive systematic literature review was conducted to identify neoadjuvant studies in resectable non-small cell lung cancer. Analysis at the patient level using frequentist and Bayesian random effects (hazard …


Alterations In Brain Morphometric Networks And Their Relationship With Memory Dysfunction In Patients With Type 2 Diabetes Mellitus, Rye Young Kim, Yoonji Joo, Eunji Ha, Haejin Hong, Chaewon Suh, Youngeun Shim, Hyeonji Lee, Yejin Kim, Jae-Hyoung Cho, Sujung Yoon, In Kyoon Lyoo Apr 2024

Alterations In Brain Morphometric Networks And Their Relationship With Memory Dysfunction In Patients With Type 2 Diabetes Mellitus, Rye Young Kim, Yoonji Joo, Eunji Ha, Haejin Hong, Chaewon Suh, Youngeun Shim, Hyeonji Lee, Yejin Kim, Jae-Hyoung Cho, Sujung Yoon, In Kyoon Lyoo

Faculty, Staff and Student Publications

Cognitive dysfunction, a significant complication of type 2 diabetes mellitus (T2DM), can potentially manifest even from the early stages of the disease. Despite evidence of global brain atrophy and related cognitive dysfunction in early-stage T2DM patients, specific regions vulnerable to these changes have not yet been identified. The study enrolled patients with T2DM of less than five years’ duration and without chronic complications (T2DM group, n=100) and demographically similar healthy controls (control group, n=50). High-resolution T1-weighted magnetic resonance imaging data were subjected to independent component analysis to identify structurally significant components indicative of morphometric networks. Within these networks, the groups’ …


Quorum-Sensing Agr System Of Staphylococcus Aureus Primes Gene Expression For Protection From Lethal Oxidative Stress, Magdalena Podkowik, Andrew I Perault, Gregory Putzel, Andrew Pountain, Jisun Kim, Ashley L Dumont, Erin E Zwack, Robert J Ulrich, Theodora K Karagounis, Chunyi Zhou, Andreas F Haag, Julia Shenderovich, Gregory A Wasserman, Junbeom Kwon, John Chen, Anthony R Richardson, Jeffrey N Weiser, Carla R Nowosad, Desmond S Lun, Dane Parker, Alejandro Pironti, Xilin Zhao, Karl Drlica, Itai Yanai, Victor J Torres, Bo Shopsin Apr 2024

Quorum-Sensing Agr System Of Staphylococcus Aureus Primes Gene Expression For Protection From Lethal Oxidative Stress, Magdalena Podkowik, Andrew I Perault, Gregory Putzel, Andrew Pountain, Jisun Kim, Ashley L Dumont, Erin E Zwack, Robert J Ulrich, Theodora K Karagounis, Chunyi Zhou, Andreas F Haag, Julia Shenderovich, Gregory A Wasserman, Junbeom Kwon, John Chen, Anthony R Richardson, Jeffrey N Weiser, Carla R Nowosad, Desmond S Lun, Dane Parker, Alejandro Pironti, Xilin Zhao, Karl Drlica, Itai Yanai, Victor J Torres, Bo Shopsin

Faculty, Staff and Student Publications

The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that protection by agr surprisingly extends beyond post-exponential growth to the exit from stationary phase when the agr system is no longer turned on. Thus, agr can be considered a constitutive protective factor. Deletion of agr resulted in decreased ATP levels and growth, despite increased rates of respiration or fermentation at appropriate oxygen tensions, suggesting that Δagr cells undergo a shift towards a hyperactive metabolic …


Sildenafil Versus Placebo For Early Pulmonary Vascular Disease In Scleroderma (Sepvadis): Protocol For A Randomized Controlled Trial, Matthew R. Lammi, Monica Mukherjee, Lesley Ann Saketkoo, Kyle Carey, Laura Hummers, Steven Hsu, Amita Krishnan, Marie Sandi, Ami A. Shah, Stefan L. Zimmerman, Paul M. Hassoun, Steven C. Mathai Apr 2024

Sildenafil Versus Placebo For Early Pulmonary Vascular Disease In Scleroderma (Sepvadis): Protocol For A Randomized Controlled Trial, Matthew R. Lammi, Monica Mukherjee, Lesley Ann Saketkoo, Kyle Carey, Laura Hummers, Steven Hsu, Amita Krishnan, Marie Sandi, Ami A. Shah, Stefan L. Zimmerman, Paul M. Hassoun, Steven C. Mathai

School of Medicine Faculty Publications

BACKGROUND: Pulmonary hypertension (PH) is a leading cause of death in patients with systemic sclerosis (SSc). An important component of SSc patient management is early detection and treatment of PH. Recently the threshold for the diagnosis of PH has been lowered to a mean pulmonary artery pressure (mPAP) threshold of > 20 mmHg on right heart catheterization (RHC). However, it is unknown if PH-specific therapy is beneficial in SSc patients with mildly elevated pressure (SSc-MEP, mPAP 21-24 mmHg). METHODS: The SEPVADIS trial is a randomized, double-blind, placebo-controlled phase 2 trial of sildenafil in SSc-MEP patients with a target enrollment of 30 …


Spatial Ability Tests And Course Performance In Human Anatomy And Physiology I Students, Madeline Hinton Apr 2024

Spatial Ability Tests And Course Performance In Human Anatomy And Physiology I Students, Madeline Hinton

Honors Theses

Madeline Hinton: Spatial Ability Tests and Course Performance in Human Anatomy and Physiology I Students

(Under the direction of Dr. Carol Britson)

Visuospatial perception processing is our ability to make inferences about what an object might look like from different angles just by looking at one angle of the object or by looking at a two-dimensional representation of it. This is a skill tested on the perceptual ability portion of the Dental Admissions Test (DAT), and it is also crucial for Human Anatomy and Physiology (HAP) students to be proficient in this skill in order to successfully navigate the organ …


Self-Reported Determinants Of Covid-19 Vaccine Acceptance Among Persons With And Without Autoimmune Disease, Jenny D. Gong, Maya Mattar, Donald D. Anthony, Adam T. Perzynski, Nora G. Singer Apr 2024

Self-Reported Determinants Of Covid-19 Vaccine Acceptance Among Persons With And Without Autoimmune Disease, Jenny D. Gong, Maya Mattar, Donald D. Anthony, Adam T. Perzynski, Nora G. Singer

Faculty Scholarship

Objective: Patients with autoimmune disease (AD) are at increased risk for complications from COVID-19 infection, so, optimizing vaccine utilization in this population is of particular importance. We compared COVID-19 vaccination perspectives among persons with and without AD. Methods: 471 patients in the MetroHealth System and Cleveland Veteran Affairs Medical Center completed a 38-item questionnaire between August 2021 and February 2022. This survey containing questions regarding COVID-19 vaccine perceptions and demographics was administered both to unvaccinated individuals and individuals who delayed vaccination for at least 2 months. Multivariable ordinary least squares regression models were created to assess factors associated with vaccination …


Overexpression Of Fatty Acid Synthase Upregulates Glutamine–Fructose-6-Phosphate Transaminase 1 And O-Linked N-Acetylglucosamine Transferase To Increase O-Glcnac Protein Glycosylation And Promote Colorectal Cancer Growth, James Drury, Mariah E. Geisen, Josiane Weber Tessmann, Piotr G. Rychahou, Courtney O. Kelson Apr 2024

Overexpression Of Fatty Acid Synthase Upregulates Glutamine–Fructose-6-Phosphate Transaminase 1 And O-Linked N-Acetylglucosamine Transferase To Increase O-Glcnac Protein Glycosylation And Promote Colorectal Cancer Growth, James Drury, Mariah E. Geisen, Josiane Weber Tessmann, Piotr G. Rychahou, Courtney O. Kelson

Markey Cancer Center Faculty Publications

Fatty acid synthesis has been extensively investigated as a therapeutic target in cancers, including colorectal cancer (CRC). Fatty acid synthase (FASN), a key enzyme of de novo lipid synthesis, is significantly upregulated in CRC, and therapeutic approaches of targeting this enzyme are currently being tested in multiple clinical trials. However, the mechanisms behind the pro- oncogenic action of FASN are still not completely understood. Here, for the first time, we show that overexpression of FASN increases the expression of glutamine–fructose-6-phosphate transaminase 1 (GFPT1) and O-linked N-acetylglucosamine transferase (OGT), enzymes involved in hexosamine metabolism, and the level of O-GlcNAcylation in vitro …


Treatment At An Academic Medical Center Eliminates Survival Disparities For Appalachian Kentuckians With Pancreatic Ductal Adenocarcinoma, Emily Cassim, Hannah Mcdonald, Megan Harper, Quan Chen, Miranda Lin, Reema Patel, Michael Cavnar, Prakash Pandalai, Bin Huang, Pamela C. Hull, Joseph Kim, Erin Burke Apr 2024

Treatment At An Academic Medical Center Eliminates Survival Disparities For Appalachian Kentuckians With Pancreatic Ductal Adenocarcinoma, Emily Cassim, Hannah Mcdonald, Megan Harper, Quan Chen, Miranda Lin, Reema Patel, Michael Cavnar, Prakash Pandalai, Bin Huang, Pamela C. Hull, Joseph Kim, Erin Burke

Journal of Appalachian Health

Introduction: Rates of cancer mortality in Appalachian Kentucky is among the highest in the nation. It is unknown whether geographic location of treatment for pancreatic ductal adenocarcinoma (PDAC), one of the deadliest cancers worldwide, influences survival in Appalachian Kentuckians.

Purpose: This study compares outcomes among Appalachian Kentuckians with PDAC who received treatment at an academic medical center (AMC) or community facility (CF).

Methods: Using the Kentucky Cancer Registry, patients diagnosed with PDAC between 2003 and 2018 were identified. Patients were categorized according to treatment location (AMC v. CF) and county of residence (Appalachian v. non-Appalachian). Kaplan-Meier curves were constructed to …


Conscientious Objection: Understanding When And Why Primary Care Physicians Object To Providing Health Care To Transgender And Gender-Diverse Patients In An Appalachian Medical Center, Mili S. Patel, Kelley A. Jones, Laura Davisson, Elizabeth Miller, Nicole Kahn, Pamela J. Murray, Kacie M. Kidd Apr 2024

Conscientious Objection: Understanding When And Why Primary Care Physicians Object To Providing Health Care To Transgender And Gender-Diverse Patients In An Appalachian Medical Center, Mili S. Patel, Kelley A. Jones, Laura Davisson, Elizabeth Miller, Nicole Kahn, Pamela J. Murray, Kacie M. Kidd

Journal of Appalachian Health

Introduction: Transgender and gender-diverse (TGD) individuals face barriers to accessing primary and gender-affirming care, especially in rural regions where a national shortage of medical providers with skills in caring for TGD people is further magnified. This care may also be impacted by individual providers’ strongly held personal or faith beliefs and associated conscientious objection to care.

Purpose: This study assesses the prevalence of conscientious objection to providing care and gender-affirming hormone (GAH) therapy to TGD individuals among physicians in an Appalachian academic medical center.

Methods: An anonymous, online, cross-sectional survey of physicians was distributed to resident and faculty physicians in …


Check With The Intended Audience First! Content Validation As A Method For Inclusive Research For Primary Care Engagement In Rural Appalachia, Sydeena E. Isaacs, Jennifer Schroeder Tyson, Ashley Parks, Danielle Adams Apr 2024

Check With The Intended Audience First! Content Validation As A Method For Inclusive Research For Primary Care Engagement In Rural Appalachia, Sydeena E. Isaacs, Jennifer Schroeder Tyson, Ashley Parks, Danielle Adams

Journal of Appalachian Health

Introduction: To date, referral practices based on social determinants of health (SDOH) among primary care providers (PCPs) and clinic staff in rural regions, including Appalachian North Carolina (NC), are not well understood.

Purpose: This study aims to develop and content validate a primary care engagement (PCE) survey to assess (1) engagement and burnout; (2) referral practices; and (3) self-efficacy and confidence in making referrals based on SDOH among PCPs and clinic staff in Appalachian NC.

Methods: Using the Social-Ecological Model as a theoretical framework, researchers developed a 37-item PCE survey. Content validation was completed by a panel of experts recruited …


Dronedarone For The Treatment Of Atrial Arrhythmias In Adults With Congenital Heart Disease, Mahdi S Agha, Peter R Ermis, Wayne J Franklin, Dhaval R Parekh, Angeline D Opina, Jeffrey J Kim, Christina Y Miyake, Santiago O Valdes, Wilson W Lam Apr 2024

Dronedarone For The Treatment Of Atrial Arrhythmias In Adults With Congenital Heart Disease, Mahdi S Agha, Peter R Ermis, Wayne J Franklin, Dhaval R Parekh, Angeline D Opina, Jeffrey J Kim, Christina Y Miyake, Santiago O Valdes, Wilson W Lam

The Texas Heart Institute Journal

Background: Atrial tachyarrhythmias are common and difficult to treat in adults with congenital heart disease. Dronedarone has proven effective in patients without congenital heart disease, but data are limited about its use in adults with congenital heart disease of moderate to great complexity.

Methods: A single-center, retrospective chart review of 21 adults with congenital heart disease of moderate to great complexity who were treated with dronedarone for atrial tachyarrhythmias was performed.

Results: The median (IQR) age at dronedarone initiation was 35 (27.5-39) years. Eleven patients (52%) were male. Ten patients (48%) had New York Heart Association class I disease, 10 …


Dronedarone For The Treatment Of Atrial Arrhythmias In Adults With Congenital Heart Disease, Mahdi S Agha, Peter R Ermis, Wayne J Franklin, Dhaval R Parekh, Angeline D Opina, Jeffrey J Kim, Christina Y Miyake, Santiago O Valdes, Wilson W Lam Apr 2024

Dronedarone For The Treatment Of Atrial Arrhythmias In Adults With Congenital Heart Disease, Mahdi S Agha, Peter R Ermis, Wayne J Franklin, Dhaval R Parekh, Angeline D Opina, Jeffrey J Kim, Christina Y Miyake, Santiago O Valdes, Wilson W Lam

The Texas Heart Institute Journal

BACKGROUND: Atrial tachyarrhythmias are common and difficult to treat in adults with congenital heart disease. Dronedarone has proven effective in patients without congenital heart disease, but data are limited about its use in adults with congenital heart disease of moderate to great complexity.

METHODS: A single-center, retrospective chart review of 21 adults with congenital heart disease of moderate to great complexity who were treated with dronedarone for atrial tachyarrhythmias was performed.

RESULTS: The median (IQR) age at dronedarone initiation was 35 (27.5-39) years. Eleven patients (52%) were male. Ten patients (48%) had New York Heart Association class I disease, 10 …


Implementation Of A Standardized Process To Increase Referrals To The Tobacco Quitline In An Underserved General Oncology Cancer Survivorship Clinic, Kristyn-Mae Rosales Apr 2024

Implementation Of A Standardized Process To Increase Referrals To The Tobacco Quitline In An Underserved General Oncology Cancer Survivorship Clinic, Kristyn-Mae Rosales

Doctor of Nursing Practice Final Project Abstract

PURPOSE The purpose of this scholarly project was to implement a standardized process to increase referral rates to the tobacco quitline among cancer survivors in an outpatient center. The intent was to promote the usage of tobacco cessation resources for this vulnerable population.

BACKGROUND “Cigarette smoking remains the leading cause of preventable disease, disability, and death in the United States” (CDC, 2023). This project was implemented in an ambulatory clinic among the Harris County population, Houston, Texas. The aim of this project was to increase the number of quitline referrals by 20% in six months.

METHODOLOGY Interventions were implemented to …


Effectiveness Of A Positive Psychotherapy Tool In Reducing Burnout And Increasing Morale Of Night Shift Mental Health Workers On An Acute Pediatric Psychiatric Floor, Esther Gatonye Apr 2024

Effectiveness Of A Positive Psychotherapy Tool In Reducing Burnout And Increasing Morale Of Night Shift Mental Health Workers On An Acute Pediatric Psychiatric Floor, Esther Gatonye

Doctor of Nursing Practice Final Project Abstract

Purpose: This scholarly project's purpose was to enhance the well-being of mental healthcare workers on the night shift in an acute pediatric mental health unit by implementing the Three Good Things (3GT) positive psychotherapy tool. The project intended to address the issue of high burnout rates among healthcare workers and improve employee well-being and patient care.

Background: The project was implemented in a 16-bed Mental Health Unit within a pediatric hospital located in the Austin Metroplex.

Methodology: The project employed a non-randomized pre-, mid, and post-design and utilized surveys to evaluate burnout, well-being, and coping skills. Burnout was measured using …


Antioxidant, Tyrosinase Inhibition Activity, And In Vitro Spf Evaluation Of Pepino Fruit Extract (Solanum Muricatum Aiton) In Different Solvent Types And Concentrations, Nining Sugihartini, Girly Risma Firsty, Wahyu Kumil Laila, Sri Mulyaningsih, Ichwan Ridwan Rais Apr 2024

Antioxidant, Tyrosinase Inhibition Activity, And In Vitro Spf Evaluation Of Pepino Fruit Extract (Solanum Muricatum Aiton) In Different Solvent Types And Concentrations, Nining Sugihartini, Girly Risma Firsty, Wahyu Kumil Laila, Sri Mulyaningsih, Ichwan Ridwan Rais

Pharmaceutical Sciences and Research

Solvent is a key factor that affects the effectiveness of active compound extraction from plant materials (simplisia). This study aimed to determine the optimal type and concentration of solvent used in the extraction of pepino fruit based on the parameter of antioxidant and tyrosinase inhibition activity, as well as Sun Protection Factor (SPF) value. The extraction was carried out using the maceration method with ethanol or ethyl acetate as the solvent, each at concentrations of 50%, 70%, and 96%, respectively. The antioxidant activity of the extracts was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The inhibition of tyrosinase and …


Factors Predicting Work Ability Among Community Healthcare Providers In Yangon, Myanmar, Phyu Nyein Wai, Naw Clara Apr 2024

Factors Predicting Work Ability Among Community Healthcare Providers In Yangon, Myanmar, Phyu Nyein Wai, Naw Clara

Makara Journal of Health Research

Background: In healthcare organizations, a high level of work ability is necessary for workers to perform their tasks under different working conditions. This study aimed to describe the quality of work life, work environment, and work ability and examine predictors of the work ability of community healthcare providers.

Methods: A cross-sectional descriptive study was conducted from May 2020 to July 2020. The study enrolled 284 registered nurses and midwives from 38 public health departments in Yangon, Myanmar. Data were collected using the work-related quality of life scale (WRQoL) 2, work environment impact scale (WEIS-SR), and work ability index …


Perception Of Lean Adoption Among Emergency Department Personnel In Public Hospitals In Selangor, Malaysia, Azizul Rahman Mohamad Jamil, Mohd Rizal Abdul Manaf, Sharifa Ezat Wan Puteh, Kiran Ganesh Balakrishnan Apr 2024

Perception Of Lean Adoption Among Emergency Department Personnel In Public Hospitals In Selangor, Malaysia, Azizul Rahman Mohamad Jamil, Mohd Rizal Abdul Manaf, Sharifa Ezat Wan Puteh, Kiran Ganesh Balakrishnan

Makara Journal of Health Research

Background: This research aims to assess the perceptions of the staff working in emergency departments in Selangor, Malaysia, regarding the adoption of lean management and identify the factors that affect their perceptions.

Methods: A cross-sectional study using the Lean in Healthcare Questionnaire was conducted with 251 respondents, which consisted of doctors, nurses and medical assistants employed in three selected hospitals.

Results: One-way analysis of variance (ANOVA) showed a significant difference in every domain score in accordance with the occupation category. For the domain process, a significant negative correlation was found between age and domain score (r = …


Healthcare Provider Engagement And Its Effects On Patient Rereferral: Insights From Indonesia, Felicia Setiawan Apr 2024

Healthcare Provider Engagement And Its Effects On Patient Rereferral: Insights From Indonesia, Felicia Setiawan

Makara Journal of Health Research

Background: In the highly competitive landscape of healthcare, nurturing strong relationships between referring healthcare providers and healthcare facilities is essential for maintaining patient loyalty. This study explores the factors influencing referring health care provider engagement and its subsequent impact on the willingness to rerefer to healthcare facilities.

Methods: A cross-sectional quantitative survey was conducted with 181 healthcare providers who regularly refer patients to a private hospital in Jakarta. Data were collected through an online structured questionnaire consisting of 29 questions. The following dimensions were covered: specialist characteristics, practice characteristics, healthcare provider–specialist interaction, patient–specialist interaction, returning referral, training opportunity, …


Barriers And Facilitators Of Pharmacists’ Roles During The Pandemic In Malaysia, Thanushiri Palani Velu, Farida Islahudin, Wei Wen Chong Apr 2024

Barriers And Facilitators Of Pharmacists’ Roles During The Pandemic In Malaysia, Thanushiri Palani Velu, Farida Islahudin, Wei Wen Chong

Makara Journal of Health Research

Background: The coronavirus disease 2019 (COVID-19) left a devastating impact on healthcare systems worldwide. The crisis initially emerged as a supply disruption issue but eventually evolved into a myriad of additional challenges, which were attributed mainly to the extensive scale of the pandemic. This study aimed to explore the barriers to the role of hospital pharmacists and related facilitators encountered during the COVID-19 pandemic.

Methods: Pharmacists in Malaysia participated in a cross-sectional online questionnaire-based survey. The participants were recruited using convenient sampling. Cronbach alpha of the questionnaire was analyzed.

Results: The study successfully enrolled 367 pharmacists. The …


Most Common Symptoms Of Prediabetic And Insulin Resistance In Adults In Saudi Arabia, Hassan Mazzhar Bukhari, Fatoon Mohammed Albuqami, Alanoud Mohammed Asiri, Ghadeer Othman Yatim, Jomana Abdullah Alshareef, Ruba Saeed Alzahrani Apr 2024

Most Common Symptoms Of Prediabetic And Insulin Resistance In Adults In Saudi Arabia, Hassan Mazzhar Bukhari, Fatoon Mohammed Albuqami, Alanoud Mohammed Asiri, Ghadeer Othman Yatim, Jomana Abdullah Alshareef, Ruba Saeed Alzahrani

Makara Journal of Health Research

Background: The prediabetic stage exhibits common symptoms; hence, the risk of developing diabetes can be reduced by identifying these symptoms in the most affected population. This study aimed to examine the prevalence of the main symptoms of insulin resistance in healthy adults aged 18 years and above.

Methods: A cross-sectional study was conducted on 1,514 Saudi adults using an online questionnaire collected from 13th November 2020 to 23rd March 2021. Data on personal, lifestyle, and common symptoms were gathered, and the main symptoms were presented as frequencies with percentages. Association with insulin resistance was evaluated using the Chi-square …


Assessment Of Sociodemographic Status, Self-Awareness, And Risk Factors Affecting Patients With Prediabetes In Bangladesh: Cross-Sectional Study, Farhana Sultana, Muhammed Mohibul Islam, Aparajita Das, Md Hasan Shahriar Rahman, Nandita Islam Pia, Md Kayes Mahmud, Md. Saqline Mostaq, Saadullah Saadullah, Md. Saddam Hossain, Saikat Fakir, Mohammad Nurul Amin Apr 2024

Assessment Of Sociodemographic Status, Self-Awareness, And Risk Factors Affecting Patients With Prediabetes In Bangladesh: Cross-Sectional Study, Farhana Sultana, Muhammed Mohibul Islam, Aparajita Das, Md Hasan Shahriar Rahman, Nandita Islam Pia, Md Kayes Mahmud, Md. Saqline Mostaq, Saadullah Saadullah, Md. Saddam Hossain, Saikat Fakir, Mohammad Nurul Amin

Makara Journal of Health Research

Background: Poor glycemic control and high diabetes and prediabetes incidence are influenced by socioeconomic disparity. Raising awareness and ensuring that people with prediabetes are receiving medication, maintaining their glycemic control, and getting the proper care they need despite their socioeconomic situation are crucial in the fight against diabetes. This study aims to assess the sociodemographic status, self-awareness, and risk factors associated with prediabetes in Bangladesh.

Methods: A cross-sectional survey was carried out among 500 participants aged >18 years to evaluate and summarize their demographic data, socioeconomic status, and responses to various questionnaires about their conditions related to prediabetes …


Determinant Of Unintended Pregnancy In Indonesia, Pika Novriani Lubis, Ratna Djuwita, Asri C. Adisasmita, Sudarto Ronoatmodjo, Maria Gayatri Apr 2024

Determinant Of Unintended Pregnancy In Indonesia, Pika Novriani Lubis, Ratna Djuwita, Asri C. Adisasmita, Sudarto Ronoatmodjo, Maria Gayatri

Makara Journal of Health Research

Background: Unintended pregnancy is a global health problem. The number of unintended pregnancies globally is still high, accounting for 1 in 4 pregnancies. In Indonesia, it occupies 15% of total pregnancies. However, studies discussing the determinants of unintended pregnancies in Indonesia were conducted on a small scale.

Methods: This cross-sectional research utilized the data of 15,316 respondents of the 2017 Indonesia Demographic and Health Survey.

Results: The prevalence of unintended pregnancies in women with live births in the last 3–5 years was approximately 16%. The highest risk of unintended pregnancies was recorded for those with the youngest …


Disaster Response Self-Efficacy Of Students In The Nursing Department: A Cross-Sectional Study, Dilek Yılmaz, Gonca Buran Apr 2024

Disaster Response Self-Efficacy Of Students In The Nursing Department: A Cross-Sectional Study, Dilek Yılmaz, Gonca Buran

Makara Journal of Health Research

Background: Nurses take on important roles in disasters. In this regard, the disaster response self-efficacy of nursing students must be evaluated. The study aimed to determine the self-efficacy of nursing students in disaster response.

Methods: In this descriptive cross-sectional study, the study sample consisted of 207 nursing students who were in their third or fourth year attending the nursing department of a state university in the Marmara region of Türkiye between October and December 2023. Data were collected using a student description form and the disaster response self-efficacy scale.

Results: The mean age of the study participants …


Investigating Nursing Students’ Levels Of Knowledge About Alzheimer’S Disease, Dilek Doruk Kondakci, Aliye Mandiracioğlu Apr 2024

Investigating Nursing Students’ Levels Of Knowledge About Alzheimer’S Disease, Dilek Doruk Kondakci, Aliye Mandiracioğlu

Makara Journal of Health Research

Background: Given that Alzheimer’s disease (AD) has become a major public health problem, this study aimed to investigate the AD knowledge level of nursing students who are health professional candidates.

Methods: The population of this cross-sectional study consisted of 346 nursing students taking up a 4-year program. They were asked to fill out a sociodemographic information form and answer questions from the Alzheimer’s Disease Knowledge Scale (ADKS).

Results: Among the participants, 67.6% were female and 98.8% were single. The mean age of the students was 20.55 ± 2.05 years. Their general knowledge about AD was low, with …


Loss Of Tumor Suppressor Tmem127 Drives Ret-Mediated Transformation Through Disrupted Membrane Dynamics, Timothy J Walker, Eduardo Reyes-Alvarez, Brandy D Hyndman, Michael G Sugiyama, Larissa C B Oliveira, Aisha N Rekab, Mathieu J F Crupi, Rebecca Cabral-Dias, Qianjin Guo, Patricia L M Dahia, Douglas S Richardson, Costin N Antonescu, Lois M Mulligan Apr 2024

Loss Of Tumor Suppressor Tmem127 Drives Ret-Mediated Transformation Through Disrupted Membrane Dynamics, Timothy J Walker, Eduardo Reyes-Alvarez, Brandy D Hyndman, Michael G Sugiyama, Larissa C B Oliveira, Aisha N Rekab, Mathieu J F Crupi, Rebecca Cabral-Dias, Qianjin Guo, Patricia L M Dahia, Douglas S Richardson, Costin N Antonescu, Lois M Mulligan

Faculty, Staff and Student Publications

Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTKs) are important regulators of signaling in normal cells that can frequently be disrupted in cancer. The adrenal tumor pheochromocytoma (PCC) can be caused by activating mutations of the rearranged during transfection (RET) receptor tyrosine kinase, or inactivation of TMEM127, a transmembrane tumor suppressor implicated in trafficking of endosomal cargos. However, the role of aberrant receptor trafficking in PCC is not well understood. Here, we show that loss of TMEM127 causes wildtype RET protein accumulation on the cell surface, where increased receptor density facilitates constitutive ligand-independent activity and …


Effect Of Taper And Pitch On Nickle-Titanium File With Variable Cross Section To Its Cyclic Fatigue (In Silico Study), Yustika Chrysandra, Tunjung Nugraheni, Wignyo Hadriyanto Apr 2024

Effect Of Taper And Pitch On Nickle-Titanium File With Variable Cross Section To Its Cyclic Fatigue (In Silico Study), Yustika Chrysandra, Tunjung Nugraheni, Wignyo Hadriyanto

Journal of Dentistry Indonesia

The geometric design of an endodontic file includes cross-sectional shape, taper, and pitch. NiTi endodontic files of OneCurve (MicroMega) are made of two variations of cross-sectional shape, that is, double-s shaped and triple helix. Various kinds of modifications were made to increase the resistance of the NiTi endodontic files from fracture. Cyclic fatigue is the most common factor that causes a fracture of the endodontic file. Objective: The purpose of this study was to obtain a NiTi endodontic file design that has the best cyclic resistance value based on its taper size and number of pitch. Methods: This …


Effect Of Ultrasonic Combined With Solvent On Gutta-Percha And Bioceramic Sealer Removal In Middle And Apical Third Of The Root Canal: An Ex Vivo Study, Eko Fibryanto, Wiena Widyastuti, Adi Hidayat, Lisiana Hastuty Apr 2024

Effect Of Ultrasonic Combined With Solvent On Gutta-Percha And Bioceramic Sealer Removal In Middle And Apical Third Of The Root Canal: An Ex Vivo Study, Eko Fibryanto, Wiena Widyastuti, Adi Hidayat, Lisiana Hastuty

Journal of Dentistry Indonesia

Objective: This study aims to investigate the effectiveness of ultrasonic tip with and without solvent in removing gutta-perca and bioceramic sealer from the middle and apical third of the root canals. Methods: This is a true experimental study with randomized pretest-posttest control group design. Eighteen freshly extracted straight single-rooted mandibular first premolars were confirmed by CBCT and selected. The teeth were decoronated until a length of 16 ± 0.5mm. The teeth were prepared and obturated using gutta-percha and bioceramic sealer with a hydraulic condensation technique. Pre-instrumentation CBCT imaging of all teeth was carried out to obtain the initial volume of …


Reliability Of Three-Dimensional Micro-Computed Tomography Root Canal Analysis Using Drishti Software: A Pilot Study, Nurulaqmar Iwani Samsudin, Marlena Kamaruzaman, Afiq Azizi Jawami Apr 2024

Reliability Of Three-Dimensional Micro-Computed Tomography Root Canal Analysis Using Drishti Software: A Pilot Study, Nurulaqmar Iwani Samsudin, Marlena Kamaruzaman, Afiq Azizi Jawami

Journal of Dentistry Indonesia

In recent years, micro-computed tomography (micro-CT) has become a promising tool for non-destructive imaging and the study of root canal morphology in endodontics. However, the reliability of such analyses heavily relies on the accuracy and consistency of the software used for image processing. Objective: This study aims to investigate the reliability of two different micro-CT voxel sizes using open-source three-dimensional (3D) software (Drishti v3.0) used to identify and quantify the Apical Foramen (AF) and Apical Constriction (AC) in mandibular premolars. Methods: Eight mandibular premolars were divided into two groups, with four samples in each group. Samples were scanned using a …


Epidemiology Of Bruxism And Temporomandibular Joint Disorders (Tmd) In Iranian Adults: A Cross-Sectional Study, Parviz Amini, Maryam Sharifi, Reyhane Aftabi, Fatemeh Jahanimoghadam, Hamidreza Jahanimoghadam Apr 2024

Epidemiology Of Bruxism And Temporomandibular Joint Disorders (Tmd) In Iranian Adults: A Cross-Sectional Study, Parviz Amini, Maryam Sharifi, Reyhane Aftabi, Fatemeh Jahanimoghadam, Hamidreza Jahanimoghadam

Journal of Dentistry Indonesia

Objective: The prevalence of bruxism in the literature has been reported differently. The aim of this study was to assess the prevalence of bruxism in patients aged 25–40 who were referred to Kerman Dental School. Methods: This analytical descriptive cross-sectional study was performed on 320 patients referred to the Department of Oral Medicine of Kerman Dentistry Faculty in the age range of 25 to 40 years old. The prevalence of bruxism as well as TMJ disorders were evaluated. Data were collected in a questionnaire and entered into SPSS version 24. Analyzing was done by a chi-square test at …


Investigation Of The Effect Of The Covid-19 Pandemic On Anxiety Levels And Career Satisfaction Of Dentistry Students, Furkan Kır, Ata Batuhan Bayrak, Mediha Büyükgöze-Dindar Apr 2024

Investigation Of The Effect Of The Covid-19 Pandemic On Anxiety Levels And Career Satisfaction Of Dentistry Students, Furkan Kır, Ata Batuhan Bayrak, Mediha Büyükgöze-Dindar

Journal of Dentistry Indonesia

Objective: This study aimed to investigate the effect of the COVID-19 pandemic on the anxiety levels and career satisfaction of dentistry students. Methods: A total of 220 dentistry students were included in the study. A questionnaire was mailed to dentistry students at Trakya University between June 2021 and January 2022. Beck Anxiety Inventory (BAI) was used to evaluate anxiety levels. Data were analyzed, and p < 0.05 was considered statistically significant. Results: The mean BAI scores of the participants were 14.6 ± 13.6. The anxiety levels of the females were significantly higher than the males (p = 0.004). There was a significant relationship …