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Articles 53341 - 53370 of 325394
Full-Text Articles in Medicine and Health Sciences
Female Leaders In Occupational Safety And Health: Perceived Barriers And Potential Interventions, Jacqueline Basham
Female Leaders In Occupational Safety And Health: Perceived Barriers And Potential Interventions, Jacqueline Basham
Masters Theses & Specialist Projects
Limited research exists about the challenges women face working as leaders within the occupational safety and health (OSH) industry. This study aimed to help fill this gap by utilizing key informant interviews to qualitatively analyze what the perceptions of female safety leaders were within OSH related to barriers and interventions to sustain or increase the number of female safety leaders. Both convenience sampling and snowball sampling methods were utilized to recruit female safety leaders to participate in key informant interviews. In order to be eligible for inclusion in the study, participants needed to identify as female, be safety leaders currently …
Synthesis Of Gold Nanoparticles Via Pulsed Liquid Ablation For Use In The Photodynamic Therapy Of Bacteria, Justice Ben Yosef
Synthesis Of Gold Nanoparticles Via Pulsed Liquid Ablation For Use In The Photodynamic Therapy Of Bacteria, Justice Ben Yosef
Masters Theses & Specialist Projects
With the ever-increasing threat of antibiotic resistant bacteria, alternative treatment methods have been developed including photodynamic therapy (PDT). Within the PDT process, photosensitizers are used to generate reactive oxygen species (ROS) and facilitate the cell termination process. This work lays the conceptual foundation for the functionalization of the photosensitizer methylene blue (MB) with gold nanoparticles (AuNPs) and INF-55 as a potential inhibitor of the AcrAB-TolC efflux pump to enhance the effectivity of the PDT process.
AuNPs were synthesized using pulsed laser ablation in an aqueous citrate solution. Both nanosecond and picosecond pulse durations, as well as both 532 nm and …
Health Sciences Library Newsletter May-June 2024, Jessica A. Koos, Sunny Chung, Laurel Scheinfeld, Donna Darling, Michael Huang
Health Sciences Library Newsletter May-June 2024, Jessica A. Koos, Sunny Chung, Laurel Scheinfeld, Donna Darling, Michael Huang
Health Sciences Library Newsletters
This is the May/June issue of the Stony Brook University Health Sciences Library newsletter. It is a bimonthly publication.
The Threshold Of Rural Placement Frequency And Duration: A Repeated Cross-Sectional Study Examining Rural Career Aspirations Among Student Nurses, Daniel Terry, Blake Peck, Jessica Elliott, Leah East, Liz Ryan, Ed Baker, David Schmitz
The Threshold Of Rural Placement Frequency And Duration: A Repeated Cross-Sectional Study Examining Rural Career Aspirations Among Student Nurses, Daniel Terry, Blake Peck, Jessica Elliott, Leah East, Liz Ryan, Ed Baker, David Schmitz
Public and Population Health Faculty Publications and Presentations
Aim: This study aimed to explore what changes rural placement had on the perceptions of nursing students and the impact of placement frequency and duration on student considerations for rural practice.
Background: A strong rural healthcare workforce is a global concern and has led countries to look for creative ways to address this challenge. One approach is to train more health professionals, however, nursing students who grew up or lived in metropolitan or urbanised areas are suggested to be less inclined to pursue a rural career. As such it is posited that recurrent exposure to rural settings may exert a …
Identifying The Roles Of Mir-17 In Ciliogenesis And Cell Cycle, Ashwaq Alanazi
Identifying The Roles Of Mir-17 In Ciliogenesis And Cell Cycle, Ashwaq Alanazi
Pharmaceutical Sciences (PhD) Dissertations
Emerging evidence suggests a significant contribution of primary cilia to cell division and proliferation mechanisms. MicroRNAs, especially miR-17, contribute to cell cycle regulation and proliferation. Recent investigations have highlighted the dysregulated expression of miR-17 in various malignancies, underlining its potential role in cancer. However, the correlation between primary cilia and miR-17 has yet to be fully elucidated. The present study examines the presence of miR-17 in primary cilia. The miR-17 expression is studied in selected ciliary protein knockdown cells. Using in-situ hybridization (ISH), we identified the subcellular localization of miR-17 in both cilia and cell bodies. We confirmed the importance …
Sleep Menu: Maintaining A Normal Sleep Regiment In An Unfamiliar Environment, Samantha Donnell, Hallie Shiers, Nichole Demarco, Taysier Elshaikh
Sleep Menu: Maintaining A Normal Sleep Regiment In An Unfamiliar Environment, Samantha Donnell, Hallie Shiers, Nichole Demarco, Taysier Elshaikh
Nurse Residency
Key aspects of the health benefits of good sleep in the hospital setting
Glycemic Control In Type Ii Diabetics, Brianna Jordan Bsn, Rn, Caelyn Smith Bsn, Rn, Kyleigh Alt Bsn, Rn, Sarah Goslin Bsn, Rn
Glycemic Control In Type Ii Diabetics, Brianna Jordan Bsn, Rn, Caelyn Smith Bsn, Rn, Kyleigh Alt Bsn, Rn, Sarah Goslin Bsn, Rn
Nurse Residency
In type two diabetics, how does in-patient insulin protocols compare to interventions at home influence glycemic control over 6 months?
Staff Assist Process In The Emergency Department Setting, Caroline Goodnight Rn, Rasha Burkeba Rn, William Covert Rn
Staff Assist Process In The Emergency Department Setting, Caroline Goodnight Rn, Rasha Burkeba Rn, William Covert Rn
Nurse Residency
In the Emergency Department, how do zone-based response systems compare to department-wide response systems in a staff assist affect overall patient outcomes within a one-year period of time?
Early Vs. Delayed Ambulation: Impact On Postoperative Patient Outcomes During Hospitalization, Nhi D, Alex T, Hannah H
Early Vs. Delayed Ambulation: Impact On Postoperative Patient Outcomes During Hospitalization, Nhi D, Alex T, Hannah H
Nurse Residency
In post-op patients, how does early mobilization compared to delayed mobilization affect patient outcomes within hospital time?
Fall Risk And Patient Safety, Sidney Sparda, Iza Lobue, Lilly Morrissey
Fall Risk And Patient Safety, Sidney Sparda, Iza Lobue, Lilly Morrissey
Nurse Residency
In patients with increased fall risk how does using the TIPS tool compared to The Johns Hopkins Fall Risk Assessment Tool (JHFRAT) affect patient falls within an acute care setting?
Professional Socialization, Colleen Dyer Rn, Ben Torpey Rn, Drew Wunderli Rn
Professional Socialization, Colleen Dyer Rn, Ben Torpey Rn, Drew Wunderli Rn
Nurse Residency
In the on-boarding process for new graduate registered nursing staff, how does Professional socialization compare to traditional orientation influence staff retention or satisfaction after their first year of employment?
Nationwide Outcomes In Intermediate To High-Risk Pulmonary Embolism Treated With Catheter-Based Therapies, Chukwuemeka Umeh, Rahul Gupta, Priya Hotwani Md, Sabina Kumar, Mark A. Zainea, Jay Mohan
Nationwide Outcomes In Intermediate To High-Risk Pulmonary Embolism Treated With Catheter-Based Therapies, Chukwuemeka Umeh, Rahul Gupta, Priya Hotwani Md, Sabina Kumar, Mark A. Zainea, Jay Mohan
Internal Medicine Residency
Background
The mortality rate of pulmonary embolism is as high as 30% and affects 900,000 individuals in the United States per year. Catheter-based therapies (CBT), including catheter-directed thrombolysis (CDT) and mechanical thrombectomy (MT), have been developed to treat patients with intermediate- and high-risk pulmonary embolisms. This study aims to characterize the outcomes in patients admitted with intermediate or high-risk pulmonary embolism treated with MT compared with CDT.Methods
The 2020 National Inpatient Sample data was used to analyze outcomes in hospitalized pulmonary embolism patients who received CDT and MT. The primary and secondary outcomes were in-hospital mortality, length of hospital …In-Hospital Outcomes Of Patients With Lung Cancer With And Without Superior Vena Cava Thrombosis: A Nationwide Analysis., Ankushi Sanghvi, Dhairya Nanavaty, Sagar Patel, Bhavyakumar Vachhani, Mrunanjali Gaddam, Manasa Ginjupalli, Jayalekshmi Jayakumar, Nawaraj Adhikari, Rishav Sinha, Vikash Kumar, Priya Hotwani Md, Ahmed Nadeem
In-Hospital Outcomes Of Patients With Lung Cancer With And Without Superior Vena Cava Thrombosis: A Nationwide Analysis., Ankushi Sanghvi, Dhairya Nanavaty, Sagar Patel, Bhavyakumar Vachhani, Mrunanjali Gaddam, Manasa Ginjupalli, Jayalekshmi Jayakumar, Nawaraj Adhikari, Rishav Sinha, Vikash Kumar, Priya Hotwani Md, Ahmed Nadeem
Internal Medicine Residency
Meeting Abstract: 2024 ASCO Annual Meeting
Background: Malignant superior vena cava syndrome (SVCS) is a clinical problem that results from the obstruction of blood flow in the superior vena cava by an underlying malignancy. It may be caused by external compression or internal obstruction due to a thrombus or direct invasion by tumor cells. Though lung malignancy is the most common cause of SVCS, there is a lack of data on in-hospital outcomes in these patients. Methods: We queried the National Inpatient Sample 2018-2020 to identify hospitalizations with lung cancer including both small cell and non small cell lung cancer. …
Intravascular Ultrasound In Percutaneous Coronary Interventions: A Nationwide Overview Of Its Use And Outcomes, Priya Hotwani Md, Chukwuemeka Umeh Md, Rahul Gupta, Gagan Kaur Md, Raghav Dhawan, Benson Eghreriniovo, Tamanna Mohta, Payaam Mahdavian Md, Jessica Ekomerei Obi, Eseosa Sanwo, Sabina Kumar Do, Mark A. Zainea Md Fscai, Jay Mohan Do Fscai
Intravascular Ultrasound In Percutaneous Coronary Interventions: A Nationwide Overview Of Its Use And Outcomes, Priya Hotwani Md, Chukwuemeka Umeh Md, Rahul Gupta, Gagan Kaur Md, Raghav Dhawan, Benson Eghreriniovo, Tamanna Mohta, Payaam Mahdavian Md, Jessica Ekomerei Obi, Eseosa Sanwo, Sabina Kumar Do, Mark A. Zainea Md Fscai, Jay Mohan Do Fscai
Internal Medicine Residency
Background
Intravascular ultrasound (IVUS) is a valuable adjunct to angiography, aiding interventionists in evaluating lesion severity, plaque morphology, stent apposition, stent expansion, and edge dissection. IVUS-guided PCI may increase procedure time but can lead to increased stent patency rates. This study aims to provide insights into the comparative outcomes of IVUS and non-IVUS-guided PCI in real-world clinical settings.Methods
We compared outcome measures with the 2020 United States National Inpatient Sample in patients who received IVUS-guided PCI and those who did not. The primary outcome was the mortality rate between the two groups.Results
IVUS was used in 10,757 of …Gender Disparities In Outcomes Of Left Atrial Appendage Occlusion Device Placement, Manoj Kumar, Shafaqat Ali, Faryal Farooq, Priya Hotwani Md, Sanjay Kumar
Gender Disparities In Outcomes Of Left Atrial Appendage Occlusion Device Placement, Manoj Kumar, Shafaqat Ali, Faryal Farooq, Priya Hotwani Md, Sanjay Kumar
Internal Medicine Residency
Background
Atrial fibrillation (AF) is the most common cardiac arrhythmia. It is associated with profound morbidity & mortality, including a fivefold increase in stroke risk. Due to side effects & compliance issues associated with anticoagulation, left atrial appendage occlusion (LAAO) devices have emerged as an alternative approach. However, women have been underrepresented in both the PROTECT & PREVAIL trials, landmark trials supporting LAAO use.Objective
We aim to compare gender disparities in outcomes of LAAO occlusive devices.Methods
The national readmission database (2016-2020) was utilized to identify hospitalizations for LAAO placement. Cohorts were stratified by gender. A propensity score matching …Propensity Matched In-Hospital Outcomes Of Acute St Elevation Myocardial Infarction Of Left Anterior Descending (Lad) Coronary Artery In Patients With & Without Chronic Total Occlusion Of Coronaries, Manoj Kumar, Shafaqat Ali, Faryal Farroq, Sanchit Duhan, Priya Hotwani Md, Bijeta Keisham, Sanjay Kumar, Mahin R. Khan
Propensity Matched In-Hospital Outcomes Of Acute St Elevation Myocardial Infarction Of Left Anterior Descending (Lad) Coronary Artery In Patients With & Without Chronic Total Occlusion Of Coronaries, Manoj Kumar, Shafaqat Ali, Faryal Farroq, Sanchit Duhan, Priya Hotwani Md, Bijeta Keisham, Sanjay Kumar, Mahin R. Khan
Internal Medicine Residency
Background
Chronic total occlusion (CTO) is a near-total blockage of a coronary artery often seen during percutaneous coronary intervention for acute coronary syndrome but not directly responsible for the event.Methods
The national readmission database (2016-2020) was utilized to identify hospitalizations for STEMI, with LAD as the culprit. Cohorts were stratified based on the presence of the CTO. A Propensity Score Matching (PSM) model matched CTO and non-CTO cases. Pearson’s x2 test was applied to PSM-2 matched cohorts to compare outcomes.Results
Among 98,213 hospitalizations for LAD-STEMI, About 5.53% (N: 5,704) had CTO. After propensity matching (N=3,197), patients with CTO …Early Vs Late Extracorporeal Membrane Oxygenation (Ecmo) For Mechanical Circulatory Support, Manoj Kumar, Shafaqat Ali, Sanchit Duhan, Nomesh Kumar, Priya Hotwani Md, Sanjay Kumar, Fnu Bawna, Faryal Farooq, Muhammad Sultan, Muhammad Sohaib Afzal, M Chadi Alraies
Early Vs Late Extracorporeal Membrane Oxygenation (Ecmo) For Mechanical Circulatory Support, Manoj Kumar, Shafaqat Ali, Sanchit Duhan, Nomesh Kumar, Priya Hotwani Md, Sanjay Kumar, Fnu Bawna, Faryal Farooq, Muhammad Sultan, Muhammad Sohaib Afzal, M Chadi Alraies
Internal Medicine Residency
Background
Use of Extracorporeal membrane oxygenation (ECMO) for hemodynamic (HD) support is becoming increasingly prevalent. While potentially life-saving, ECMO use is associated with complications of its own due to widespread immune activation. We aim to compare early (≤1 day) vs late (>1 day) ECMO use for hemodynamic support.Methods
The national readmission database (2016-2020) was utilized to identify hospitalizations requiring ECMO. Cohorts were stratified based on ECMO initiation. A Propensity Score Matching (PSM) model matched patients with early vs late ECMO use. Pearson’s x2 test was applied to PSM-2 matched cohorts to compare outcomes.Results
Among 40,984 hospitalizations requiring …Psychiatric Clinicians' Perspectives On Pharmacogenetic Testing In An Inpatient Setting And A Proposal Of A Guideline For Patients With Extended Hospitalization, Michelle Dickerson, Jessica Lewis
Psychiatric Clinicians' Perspectives On Pharmacogenetic Testing In An Inpatient Setting And A Proposal Of A Guideline For Patients With Extended Hospitalization, Michelle Dickerson, Jessica Lewis
Doctoral Projects
The purpose of this doctoral project is to enhance the understanding and application of pharmacogenetic testing among inpatient psychiatric clinicians. In addition, it proposes a guideline for PGx use in patients who have been hospitalized for a duration exceeding 90 days. In modern mental health care, psychotropic medications are extensively prescribed in the treatment of numerous mental health conditions. However, the use of psychotropic medications raises concerns among patients regarding their effectiveness and possible adverse reactions, leading to a lack of adherence to therapy. Over the past two decades, researchers have been exploring the effects that genetic variants have on …
Leukocytospermia Does Not Negatively Impact Outcomes In In Vitro Fertilization Cycles With Intracytoplasmic Sperm Injection And Preimplantation Genetic Testing For Aneuploidy: Findings From 5435 Cycles, Pavan Gill, Nicolas Garrido Puchalt, Thomas Molinaro, Marie Werner, Emre Seli, James Hotaling, Philip Cheng
Leukocytospermia Does Not Negatively Impact Outcomes In In Vitro Fertilization Cycles With Intracytoplasmic Sperm Injection And Preimplantation Genetic Testing For Aneuploidy: Findings From 5435 Cycles, Pavan Gill, Nicolas Garrido Puchalt, Thomas Molinaro, Marie Werner, Emre Seli, James Hotaling, Philip Cheng
Jefferson Health - New Jersey Papers
PURPOSE: To investigate whether leukocytospermia (defined as the presence of ≥ 1 × 10
METHODS: This was a retrospective cohort study including 5425 cycles between January 2012 to December 2021 at a single large university-affiliated fertility clinic. The primary outcome was live birth rate (LBR).
RESULTS: The prevalence of leukocytospermia was 33.9% (n = 1843). Baseline characteristics including female age, BMI, AMH, Day 3 FSH, and male partner's age were similar in cycles with and without leukocytospermia. The LBR after the first euploid embryo transfer was similar in those with and without leukocytospermia (62.3% vs. 63% p = 0.625). Secondary …
Investigating The Efficacy Of Yoga Vs Traditional Physical Therapy In Chronic Low Back Pain: A Systematic Review, Courtney Andrade, Casey David, Grace Hicks-Green, Riley Young
Investigating The Efficacy Of Yoga Vs Traditional Physical Therapy In Chronic Low Back Pain: A Systematic Review, Courtney Andrade, Casey David, Grace Hicks-Green, Riley Young
DPT Capstones
Introduction: Chronic low back pain (CLBP) is a complex diagnosis causing an increase in disability and decreased quality of life. This condition is defined as having low back pain for more than three months, in which an individual experiences a decline in function due to enduring pain. Several factors contribute to CLBP including core muscle weakness and decreased motor control to allow for lumbar stability. Though CLBP can be treated in multiple ways; this systematic review (SR) investigates the treatment effects of yoga combined with physical therapy (PT) vs. PT alone to measure the disability using the Oswestry Disability Index …
Prevalence Of And Influences For Incorporating Clinically-Relevant Spanish Into Doctor Of Physical Therapy Programs, Daniela Quinones, Deyanira Verdeja Sosa, Megan Giron
Prevalence Of And Influences For Incorporating Clinically-Relevant Spanish Into Doctor Of Physical Therapy Programs, Daniela Quinones, Deyanira Verdeja Sosa, Megan Giron
DPT Capstones
Introduction. The United States has 63.7 million Hispanic/Latino individuals, and approximately 40% of Spanish speakers have limited English proficiency (LEP). Patient-provider language discordance is a major contributor towards health disparities. Hence, many health professions educators offer clinically-relevant Spanish. The primary study purposes were to: 1) identify the prevalence of Doctor of Physical Therapy (DPT) programs in the United States that incorporate clinically-relevant Spanish language learning in their curriculum; and 2) describe how DPT programs incorporate Spanish language learning in their curriculum.
Review of Literature. Researchers in a 2014 report identified 12 DPT programs offering Spanish; however, the current prevalence is …
Effects Of Using External Biofeedback In Improving Ankle Kinematics In Those With Chronic Ankle Instability Compared To Conventional Therapy Without External Biofeedback: A Systematic Review, Lachlan Cubbin, Kelli Kirkpatrick
Effects Of Using External Biofeedback In Improving Ankle Kinematics In Those With Chronic Ankle Instability Compared To Conventional Therapy Without External Biofeedback: A Systematic Review, Lachlan Cubbin, Kelli Kirkpatrick
DPT Capstones
I. Introduction: Lateral ankle sprains are amongst the most common injuries to occur in athletes and the general population alike. While most can recover without complications, there exists a considerable risk of recurrent injury which can result in ongoing difficulties related to pain, function, and overall quality of life. This high recurrence rate is due to excessive lateral deviations in the location of pressure-related variables in the foot. Ongoing instability of the foot, known as chronic ankle instability (CAI), results due to these abnormal gait and ankle kinematics which causes significantly greater inversion of the foot during initial contact of …
Falls Happen... Do Tele Sitters Vs. 1:1 Companions Make A Difference?, Jenna Flewelling Rn, Gabby Guzman Rn, Rhiannon Regan Rn
Falls Happen... Do Tele Sitters Vs. 1:1 Companions Make A Difference?, Jenna Flewelling Rn, Gabby Guzman Rn, Rhiannon Regan Rn
Nurse Residency
In patients with an increased fall risk (P), how does a tele sitter (I) compared to a 1:1 in person companion (C) affect the amount of falls that occur (O) within a hospital stay (T)?
Psychosocial Health Of Patients With A Left Ventricular Assist Device, Sarah Christensen, Trang Le, Natalie Pagenstecher
Psychosocial Health Of Patients With A Left Ventricular Assist Device, Sarah Christensen, Trang Le, Natalie Pagenstecher
Nurse Residency
Among adult patients diagnosed with advanced heart failure, what is the effect of left ventricular assist device (LVAD) implantation on self-reported measures of psychosocial health during the post implantation period?
Art-Based Occupational Therapy For Adolescents With Mental Health Conditions, Sarah Helm
Art-Based Occupational Therapy For Adolescents With Mental Health Conditions, Sarah Helm
MOT Student Capstones
Pediatric and adolescent mental health disorders have a significant impact on occupational performance. This may include difficulty in social situations, decreased ability to engage in selfcare tasks, difficulty problem solving, or difficulty during mealtime. Occupational therapy practitioners can address occupational performance in this population through art-based activities to improve emotional and sensory regulation. Research shows that visual art activities can improve emotional expression, sensory regulation, abstract thinking, communication, and self-esteem. Art-based activities can include textile crafts, painting, drawing, making things with clay, or coloring. A presentation and activity booklet were created to share the impact of art-based occupational therapy on …
The Mending Mothers Project: An Inaugural Program To Improve Knowledge In Managing Gestational Diabetes, Harry Ma, Anita Sentha, Jacimil Varquez
The Mending Mothers Project: An Inaugural Program To Improve Knowledge In Managing Gestational Diabetes, Harry Ma, Anita Sentha, Jacimil Varquez
ELMSN E-Portfolio. A collection of Scholarly and Creative Works
No abstract provided.
Bal-A-Vis-X Intervention To Improve Upper Limb Coordination In Children With Disability: A Pilot Study, Marta Boot, Zoe Clark, Kyla Hill, Mckenzie Stefanoff, Betsy Donahoe Fillmore, Trisha Renner, Bo Slutz, Mary I. Fisher
Bal-A-Vis-X Intervention To Improve Upper Limb Coordination In Children With Disability: A Pilot Study, Marta Boot, Zoe Clark, Kyla Hill, Mckenzie Stefanoff, Betsy Donahoe Fillmore, Trisha Renner, Bo Slutz, Mary I. Fisher
University of Dayton Doctor of Physical Therapy Annual Research Symposium
Purpose/Hypothesis: Balance/Auditory/Vision exercises (Bal-A-Vis-X) consists of a series of exercises using sand-filled bags and racquet balls. Most of the exercises are completed while standing on a rocker board and heavily rooted in rhythm. The rhythmic patterns are utilized to facilitate focused concentration, crossing midline, motor planning, right/left awareness, eye-hand coordination, balance, bilateral coordination, body and spatial awareness. Only a few published studies have explored Bal-A-Vis-X as an intervention in therapy. The purpose of this study was to investigate the use of Bal-A-Vis-X to improve upper limb coordination in children with motor delays.
Number of Subjects: Fifteen children with motor delays …
Using The Johns Hopkins Mobility Goal Calculator To Improve Functional Outcomes During Inpatient Stays And After Discharge, Thomas Badger Bsn, Rn, Katherine Bower Bsn, Rn, Becky Radolf Msn, Rn
Using The Johns Hopkins Mobility Goal Calculator To Improve Functional Outcomes During Inpatient Stays And After Discharge, Thomas Badger Bsn, Rn, Katherine Bower Bsn, Rn, Becky Radolf Msn, Rn
Nurse Residency
Do adult hospital inpatients achieve pre-admission baseline functionality with higher frequency using the Johns Hopkins Mobility Goal Calculator (JH-MGC) versus the standard clinical approaches to mobility?
From Cells To Clinics- The Role Of College Biology Education In Shaping Future Physician Assistants, Monica Manley
From Cells To Clinics- The Role Of College Biology Education In Shaping Future Physician Assistants, Monica Manley
Honors Theses
This thesis provides a personal reflection on translating concepts and techniques learned in multiple biology courses (i.e. microbiology, neuroscience, comparative physiology, and genetics) in to clinical practice as an intern in the emergency room of a hospital. Each selected concept contains a description followed by an example of how this knowledge relates to a specified duty of a physician assistant with in an emergency medical setting.
The Role Of Myocardin And Its Effector Proteins In Tgf-Β Induced Cytoskeletal Remodeling Of Ipf Fibroblasts, Khadijat Abolore Olawuyi
The Role Of Myocardin And Its Effector Proteins In Tgf-Β Induced Cytoskeletal Remodeling Of Ipf Fibroblasts, Khadijat Abolore Olawuyi
Biotechnology Theses
Idiopathic pulmonary fibrosis (IPF) is characterized by thickening and stiffness around the air sacs. Approved treatments like nintedanib and pirfenidone slow disease progression in IPF and often have tolerability issues. More research is needed to fully grasp the mechanisms behind abnormal cytoskeletal changes in lung cells, notably fibroblasts and epithelial cells, and their role in fibrosis progression. Previous studies suggest that myocardin expression and function, traditionally limited to smooth/cardiac development in physiology, become active in pathophysiological conditions like pleural fibrosis. Myocardin's role in liver and kidney fibrosis is known, but its involvement in IPF is unclear. To get more insights, …