Medicine and Health Sciences Commons^™

Restrictive Covenants In Surgical Care: Time To Reconsider, Andrew J. Malek, Ian L. Mcculloch, Alan Z. Yang, Goutam K. Gadiraju, Justin M. Broyles

School of Medicine Faculty Publications

No abstract provided.

Empowering Personalized Pharmacogenomics With Generative Ai Solutions, Mullai Murugan, Bo Yuan, Eric Venner, Christie M Ballantyne, Katherine M Robinson, James C Coons, Liwen Wang, Philip E Empey, Richard A Gibbs

Faculty, Staff and Students Publications

Objective: This study evaluates an AI assistant developed using OpenAI's GPT-4 for interpreting pharmacogenomic (PGx) testing results, aiming to improve decision-making and knowledge sharing in clinical genetics and to enhance patient care with equitable access.

Materials and methods: The AI assistant employs retrieval-augmented generation (RAG), which combines retrieval and generative techniques, by harnessing a knowledge base (KB) that comprises data from the Clinical Pharmacogenetics Implementation Consortium (CPIC). It uses context-aware GPT-4 to generate tailored responses to user queries from this KB, further refined through prompt engineering and guardrails.

Results: Evaluated against a specialized PGx question catalog, the AI assistant showed …

Analysis Of Research And Development Trends Of New Drugs, Ping Xu, Li Xu, Ruo-Nan Yang, Wei Li, Kaixian Chen

Bulletin of Chinese Academy of Sciences (Chinese Version)

As an important component in the pharmaceutical innovation, research and development (R&D) of new drugs stands at the forefront of a new round of life science and technology revolution and bioeconomic reform, which is of strategic significance to leading scientific and technological innovation, driving economic development, and improving people’s health and well-being. At present, continuous innovation in cutting-edge technologies, cross-domain integration of disciplines, and digital depth enablement drive active innovation in the field of new drug R&D. Both domestically and internationally, innovative small molecule drugs, antibody drugs, immune cell therapy, gene therapy and nucleic acid drugs are receiving intensive market …

Gilteritinib As Post-Transplant Maintenance For Aml With Internal Tandem Duplication Mutation Of Flt3, Mark J Levis, Geoffrey L Uy, Et Al.

2020-Current year OA Pubs

PURPOSE: Allogeneic hematopoietic cell transplantation (HCT) improves outcomes for patients with AML harboring an internal tandem duplication mutation of

METHODS: Adults with

RESULTS: Three hundred fifty-six participants were randomly assigned post-HCT to receive gilteritinib or placebo. Although RFS was higher in the gilteritinib arm, the difference was not statistically significant (hazard ratio [HR], 0.679 [95% CI, 0.459 to 1.005]; two-sided

CONCLUSION: Although the overall improvement in RFS was not statistically significant, RFS was higher for participants with detectable

A Potential Of Watercress Nasturtium Officinale Bioactive Compounds In Inhibiting Infectious Myonecrosis Virus (Imnv) By Targeting Rna-Dependent Rna Polymerase (Rdrp) Virus From Several Countries: In Silico Approach, Qurrota A’Yunin, Fatchiyah Fatchiyah, Maftuch Maftuch, Feri Eko Hermanto, Muhammad Hermawan Widyananda, Narendra Santika Hartana, Muhaimin Rifa’I, Yoga Dwi Jatmiko

Karbala International Journal of Modern Science

Infectious myonecrosis virus (IMNV) disease causes mass mortality and decreased shrimp production. The RdRp region projects to the interior, where it may function in transcription. The focus of this study was to determine the effect of amino acid polymorphisms from several countries on the structure of RdRp and identify the potential of watercress in inhibiting IMNV by targeting the RdRp protein of IMNV through an in silico approach. The results showed that the structure of the IMNV RdRp protein from Indonesia was similar to Mexico, and the protein structure from India_QDN was identical to India_QIL. Ligand binding affinity values showed …

Deconstructing Drugs: Addressing The Stigma, Harm Reduction, And Policy Solutions, Charlotte Theriault

Themis: Research Journal of Justice Studies and Forensic Science

Black and homeless people who struggle with substance use disorder (SUD), especially opioid use disorder (OUD), have experienced unique obstacles due to inequalities relating to their social determinants of health (SDOH). Historical context and peer-reviewed research were used to evaluate racial bias and expand upon the factors that contributed to the opioid crisis, the effects of COVID-19 on drug overdoses, and the presence of fentanyl in illicit drug supplies. Various studies combat the stigma surrounding substance use disorder (SUD) by acknowledging the disease as a chronic health condition. Research showed that the most effective way to combat these inequalities and …

Global Age-Sex-Specific Mortality, Life Expectancy, And Population Estimates In 204 Countries And Territories And 811 Subnational Locations, 1950–2021, And The Impact Of The Covid-19 Pandemic: A Comprehensive Demographic Analysis For The Global Burden Of Disease Study 2021, Austin E. Schumacher, Hmwe Hmwe Kyu, Catherine M. Antony, Aleksandr Y. Aravkin, Gulrez Shah Azhar, Catherine Bisignano, Katrin Burkart, Kelly M. Cercy, Eunice Chung, Kaleb Coberly, Haley Comfort, Ewerton Cousin, Garland T. Culbreth, Matthew Cunningham, Nicole Davis Weaver, Louisa Degenhardt, Lee Deitesfeld, M. Ashworth Dirac, Kara Estep, Valery L. Feigin, Abraham D. Flaxman, Luisa S. Flor, Lisa M. Force, John E. Fuller, Veincent Christian Pepito

Ateneo School of Medicine and Public Health Publications

Background

Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period.

Methods

22 223 data sources …

Lyme Disease In The Northeast: The Unintended Consequence Of Suburban Development, Hayden Neubert

Student Theses 2015-Present

This paper addresses the role of suburban development in the suburbs of the Northeastern United States in increasing human Lyme disease infection. Over the past 50 years, Lyme disease has become the most common vector-borne disease in the United States. In 2021, the two states with the most Lyme disease cases were New York and New Jersey, with a collective 6,524 cases, with Connecticut still representing 541 total cases. It is not a coincidence that case numbers are concentrated in suburban areas with high forest fragmentation. Chapter 1 of this essay analyzes how human land development disrupts bioregulatory ecosystem actors …

Burden Of Disease Scenarios For 204 Countries And Territories, 2022–2050: A Forecasting Analysis For The Global Burden Of Disease Study 2021, Stein Emil Vollset, Hazim S. Ababneh, Yohannes Habtegiorgis Abate, Cristiana Abbafati, Rouzbeh Abbasgholizadeh, Mohammadreza Abbasian, Hedayat Abbastabar, Abdallah H.A. Abd Al Magied, Samar Abd Elhafeez, Atef Abdelkader, Michael Abdelmasseh, Sherief Abd-Elsalam, Parsa Abdi, Mohammad Abdollahi, Meriem Abdoun, Auwal Abdullahi, Mesfin Abebe, Olumide Abiodun, Richard Gyan Aboagye, Hassan Abolhassani, Mohamed Abouzid, Girma Beressa Aboye, Lucas Guimarães Abreu, Abdorrahim Absalan, Veincent Christian Pepito

Ateneo School of Medicine and Public Health Publications

Background

Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternative scenarios assessing disease burden trajectories if selected sets of risk factors were eliminated from current levels by 2050.

Methods

Using forecasts of major drivers of health such as the Socio-demographic …

Global Fertility In 204 Countries And Territories, 1950–2021, With Forecasts To 2100: A Comprehensive Demographic Analysis For The Global Burden Of Disease Study 2021, Natalia V. Bhattacharjee, Austin E. Schumacher, Amirali Aali, Yohannes Habtegiorgis Abate, Rouzbeh Abbasgholizadeh, Mohammadreza Abbasian, Mohsen Abbasi-Kangevari, Hedayat Abbastabar, Samar Abd Elhafeez, Sherief Abd-Elsalam, Mohammad Abdollahi, Mohammad Amin Abdollahifar, Meriem Abdoun, Auwal Abdullahi, Mesfin Abebe, Samrawit Shawel Abebe, Olumide Abiodun, Hassan Abolhassani, Meysam Abolmaali, Mohamed Abouzid, Girma Beressa Aboye, Lucas Guimarães Abreu, Woldu Aberhe Abrha, Michael R.M. Abrigo, Veincent Christian Pepito

Ateneo School of Medicine and Public Health Publications

Background

Accurate assessments of current and future fertility—including overall trends and changing population age structures across countries and regions—are essential to help plan for the profound social, economic, environmental, and geopolitical challenges that these changes will bring. Estimates and projections of fertility are necessary to inform policies involving resource and health-care needs, labour supply, education, gender equality, and family planning and support. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 produced up-to-date and comprehensive demographic assessments of key fertility indicators at global, regional, and national levels from 1950 to 2021 and forecast fertility metrics to 2100 …

Exploring Attachment Through Clay-Based Therapy: A Parent-Child Community Engagement Project, Hilari Stahler

Expressive Therapies Capstone Theses

This research project explores the therapeutic potential of clay, particularly as a creative, sensory-rich process that facilitates access to pre-verbal memories. Grounded in attachment theory and the innovative approach to trauma healing by Cornelia Elbrecht, known as Trauma Healing at the Clay Field®, the study investigates clay's regressive and healing qualities. It examines how its smooth, skin-like texture can activate our implicit memories through sensory experiences. Utilizing a community engagement format, this study aimed to assess the effectiveness of parent-child clay field sessions in addressing intergenerational attachment trauma and unmet attachment needs. The research revealed that the unique properties of …

Artistic Expression Of Medical Experiences Of Mothers Of Color: Perspectives Using Art Therapy, Lauren Barrett

Expressive Therapies Dissertations

The purpose of this study was to qualitatively examine perspectives of mothers of color living in the US and their experiences in the healthcare system through art therapy. The study aimed to further identify personal narrative experiences of mothers of color navigating the healthcare system, promote individual voices, and acknowledge disparities impacting those within marginalized communities. The participants in this study included a total of eight identified mothers of color (non-White) living in the US. Participants took part in four weeks of consecutive art therapy sessions either in 60-minute group or individual virtual meetings. One art therapy directive was provided …

A Trauma-Informed Socially Just Approach To Working With Juvenile Justice-Involved Youth Utilizing Expressive Arts Therapy, Ciara Carr

Expressive Therapies Capstone Theses

Youth involved with the juvenile justice system often have a history of trauma and oppression resulting from their positionality and circumstances. Most juvenile justice-involved youth are boys, youth of color, low-income, LGBTQIA2S+, disabled, and traumatized. This literature review explores the history of the juvenile justice system, issues with the present-day model, and trauma-informed and transformative justice approaches to practice. The implementation of socially just, trauma-informed expressive arts therapy programs is proposed as a more equitable practice to replace commonly used punitive practices across the United States. More research is needed to understand the impact of such programs on this population …

Colorful Conversations: Enhancing Communication In Nonspeaking Toddlers Through Art Therapy, Joy Wu

Expressive Therapies Capstone Theses

The purpose of this study was to learn how art therapy helps non-speaking children ages two years old build up their communication with others. Although there are not many early publications on the benefit of art therapy to children ages two, the existing research suggests that art therapy can aid those children in speaking based on the experience of art making. During the art creation process, engaging with art materials and their potential power can enable the expression and conveyance of emotions as art serves as containment. Therefore, art therapy can assist nonspeaking toddlers to begin communicating verbally. This writer …

Art Therapy Meets Dungeons And Dragons: Supporting The Development Of Social Skills In High School Students, Ben Li

Expressive Therapies Capstone Theses

This arts-based research explores the current literature on the clinical uses of Dungeons and Dragons (D&D) using art and play therapies. Previous studies that intersect with D&D and expressive arts interventions have been traditionally focused on drama and play therapies while this study focused on open studio practices based on art therapy methodologies. D&D in clinical settings has been effective in developing social connection between peers and emotional regulation. A 10-week art therapy group was conducted in a school setting with adolescents with academic anxiety, socioemotional disabilities, and developmental disabilities. The author provided a space for participants to create art …

Regulation Through Rhythm: A Literature Review On Dance/Movement Therapy Approaches To Facilitating Nervous System Regulation, Elizabeth Barbera

Expressive Therapies Capstone Theses

Abstract

The mental health field has started to pay attention to how trauma plays into a person’s overall mental and physical well-being. Because of this more research has shown the connection between mind and body. Yet the clinical implications and literature on theories of how to treat trauma and trauma related disorders do not always connect. This review of literature seeks to analyze the literature on Porges’, Polyvagal Theory and Amighi’s, Kestenberg Movement Profiles. An investigation of the current literature makes a connection between the phylogenetic order of both the nervous system and developmental movement. Considerations of how trauma, in …

Tap Dance Therapy For Children With Medical Complexity: A Literature Review, Beth Calabrese

Expressive Therapies Capstone Theses

Although various genres of dance and movement have been studied to serve as therapeutic tools for individuals, research on tap dance for children with serious illnesses and complex medical needs is near non-existent. This thesis aims to analyze the available literature on tap dance and dance/movement therapy for children, as well as identify gaps in research in service of improving the quality of lives and mental health of children with medical complexity (CMC). Additionally, a discussion of a possible tap dance therapy (TDT) program for children with special needs related to medical complexities will be introduced, which will include evidence-based …

Embodied Co-Regulation: A Neuroregulatory-Informed Dance/Movement Therapy Transition Intervention Method For Arousal Regulation For Adolescents In A Partial Hospitalization Program, Anamaria Guzman

Expressive Therapies Capstone Theses

This thesis introduces a novel Dance/Movement Therapy (DMT) approach, focusing on nervous system arousal regulation during transitions between therapy groups. The core of the method involves a brief 5-minute exercise designed to modulate arousal levels, encompassing alertness and energy, aiming to establish a baseline homeostasis. Rooted in Polyvagal Theory and Developmental Neurobiology, the approach assumes the co-regulation of nervous systems within a group therapeutic setting. Two primary outcomes are self-assessed: 1) somatic experiences documented through narratives and 2) nervous system biodata measured using the Flowtime headband monitoring of brainwaves, heart rate, and other biomarkers. Results indicated that all six sessions …

Dance/Movement Therapy: A Novel Approach For Latino Males With Incarceration Histories In Sud Treatment, Aletia Egipciaco

Expressive Therapies Capstone Theses

This paper investigates how open clients would be to participating and engaging in Dance/Movement Therapy (DMT) sessions at a residential SUD facility. The questions asked were (1) What level of engagement would clients have and (2) How would they engage in DMT group sessions at a residential substance use disorder facility? A program lasting 8 weeks, aimed at facilitating DMT group sessions, was conducted at a residential SUD facility twice a week. The objective was to assess participant engagement levels and observe their involvement in the DMT sessions. Residents of the facility were invited voluntarily to attend the DMT groups. …

Utilizing Dance/Movement Therapy For Children With Attention-Deficit/Hyperactivity Disorder: Development Of A Method, Jayda Pearson

Expressive Therapies Capstone Theses

While there is limited research on the use of dance/movement therapy (DMT) with attention-deficit/hyperactivity disorder. This thesis introduces an intervention focused on utilizing (DMT) to assist children with ADHD in self-regulation during periods of dysregulation associated with the disorder. The research is backed by literature reviews covering various topics related to ADHD symptoms such as dysregulation, impulsivity, and attention difficulties. Furthermore, the thesis delves into the background of dance/movement therapy and explores how DMT can be integrated with other modalities such as play therapy for a comprehensive therapeutic approach.

One Stitch At A Time: Examining The Self-Care Of Art Therapists And The Potential Of Fiber Arts For Wellbeing, Elaine Chippero

Expressive Therapies Capstone Theses

The goal of this thesis was to understand why art therapists are particularly at risk for burnout, why it is essential for art therapists to engage artmaking for their own self-care, and why fiber crafts are particularly suited for self-care. The literature was collected and organized using reflective journaling and visual–tactile coding and then presented in the following review. The first two sections of the literature review include comprehensive definitions of burnout and self-care and how both concepts have been discussed in literature relating to the helping professions and specifically art therapists. The third section covers the historical context of …

Utilizing Flow Arts Movement As An Expressive Arts Therapy Tool To Treat Trauma: A Literature Review And Autoethnography, Shannon Mcgrail

Expressive Therapies Capstone Theses

This expressive arts-based autoethnography research explores the effectiveness of using flow arts movement as a tool of expressive arts therapy to treat symptoms of trauma for individuals who experienced a traumatic event in their lifetime. While research on the use of flow arts movement to treat mental illness is in its early stage, much can be drawn from the literature on expressive arts therapy and dance/movement therapy research with a range of populations addressing trauma. Through exploration of trauma through neuroscience, mind, body, and integrated mindfulness through flow, this work aims to bring an understanding of using intermodal expressive arts …

Feldenkrais And Music Informed Listening: A Neurophenomenological Perspective On Autism, Arona Primalani

Expressive Therapies Capstone Theses

Phenomenologists identify the subjective body and its felt-senses as the basis for human development and consciousness, including mental health. Several mental health disorders, when viewed from a phenomenological perspective, share common symptomology related to varying extents of fractured selves, which in turn hinders dynamic interaction between individuals, their actions, and their relationships with their social and material worlds. Autism is one such condition. Hence, I created an intervention to investigate how listening, which foster subjective and intersubjective experiences, lies at the heart of somatic and arts-based interventions. This thesis, first, begins with a summary of the presenting symptoms observed in …

Dnp Final Report: Addressing Incivility In Nursing Education: An Evidence-Based Practice Project, Michelle L. Forgy

DNP Final Reports

Incivility in nursing education remains a pervasive issue, necessitating effective interventions to address its impact on students and faculty. This project was conducted to address a perceived problem of incivility in a nursing school in northeast Texas. Guided by the Johns Hopkins evidence-based practice model, an evidence search followed by critical appraisal was undertaken to determine the most effective intervention to combat incivility within the nursing school. Because the project included no experimental procedures and did not pose physical or emotional risks to nursing students or faculty, the organizational IRB approved the project. An evidence-based educational session incorporating cognitive rehearsal …

Design, Synthesis, And Biological Evaluation Of Novel Heterocyclic Compounds For The Treatment Of Cancer And Neurodegenerative Disorders, Saloni Patel

Electronic Theses and Dissertations

Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs memory and cognitive judgment, mostly in older people. It is the leading cause of dementia in late adult life. The hallmarks of AD include neuronal loss, neuroinflammation, a build-up of extracellular amyloid beta (Aβ) plaques, intracellular neurofibrillary tangles, and extracellular neuritic plaques. Current treatment, although useful, is not adequate. Identification of therapeutic agents with the potential to alter the progress of AD is a high priority. Recent studies suggest that the Sigma-2 receptor is an attractive target for the development of disease-modifying AD drugs. Preventing the binding of Sigma-2 receptors …

Utilization Of Hepatitis B Viremic Donors (Nat+) Leads To Improved Kidney Transplant Access For Older Adult Recipients With Little To No Wait Time, Reynold I. Lopez-Soler, Cara Joyce, Laura Cotiguala, Oswaldo Aguirre, Manpreet Samra, Christine Trotter, Geraldine Zingraf, Jeffrey Sorensen, Rupinder Sodhi, Anne Thorndyke

Biostatistics Collaborative Core: Faculty Publications and Other Works

Background: Though the use of Hepatitis B viremic (HBV) donor kidneys may be a safe alternative to improve access to transplantation, there has not been wide acceptance of this practice. In this study, we determined the safety and effectiveness of HBV NAT (+) donor kidneys in a protocolized manner in an older adult population.

Methods: Over a 3-year period, 16 decreased donor kidney transplants were performed with HBV NAT+ kidneys. Recipients of HBV NAT+ kidneys were treated with entecavir started pre-operatively and continued for 52 weeks.

Results: HBV NAT+ kidneys were preferentially used in older (68 ± 5 vs. 64 …

Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function, Cliyahnelle Z. Alexander

Student Theses and Dissertations

Aerobic metabolism is known to generate damaging ROS, particularly hydrogen peroxide. Reactive oxygen species (ROS) are highly reactive molecules containing oxygen that have the potential to cause damage to cells and tissues in the body. ROS are highly reactive atoms or molecules that rapidly interact with other molecules within a cell. Intracellular accumulation can result in oxidative damage, dysfunction, and cell death. Due to the limitations of H₂O₂ (hydrogen peroxide) detectors, other impacts of ROS exposure may have been missed. HyPer7, a genetically encoded sensor, measures hydrogen peroxide emissions precisely and sensitively, even at sublethal levels, during …

Exploring The Design Space Of Antifungal Peptides, Miryam Kikhwa

Seton Hall University Dissertations and Theses (ETDs)

The synthesis, characterization, and evaluation of antifungal activity of peptides FQ15 and FG10 will be conducted to address the hypothesis. The hypothesis of this thesis is that a peptide with similar properties to AS15 would have similar activity against Cryptococcus neoformans. This study addresses the challenge of drug- resistant microbes by developing inhibitors targeting lipid flippase and exploring their potential as antimicrobial agents against Cryptococcus neoformans. Chapter 1 provides a historical context of the background on the development of antimicrobials and common antifungal treatments, as well as an introduction about C. neoformans and its resistance mechanism. Chapter 2 introduces the …

Re-Member Selfhood A Drama Therapy Intervention, Option 1, Angelique Beauchêne

Expressive Therapies Capstone Theses

Re-member Selfhood is a specific trauma-informed, drama therapy, intervention designed to meet the needs of adults with exposure to trauma and traumatic stress, who have pertinent adverse childhood experience scores and/or experience persistent trauma cycles over the lifespan concurrent with somatization. The aim of this thesis was to introduce an intervention which could function as indirect exposure and assist in the integration process taking the whole being of trauma sufferers into account, including body, mind, and soul. Additionally, the hope of this intervention is to decrease perceived physical pain, assist in the integration of the rejected aspect of self, and …

Playing With International Students From Asia: An Exploration Of Cultural Commonalities And Differences In Developmental Transformations (Dvt), Hazuki Okamoto

Expressive Therapies Capstone Theses

Asian international students in the United States face a multitude of challenges such as language barriers, differences in cultural norms and behaviors, and identity confusion while navigating a foreign landscape. Developmental Transformations (DvT), a form of drama therapy, may apply to these challenges by enabling participants to explore different identities and express themselves creatively beyond the language barrier. This community engagement project was designed for Asian international students to be seen and heard by utilizing DvT. Within an in-person workshop, five participants played with their shared stories, and explored international and cultural roles in group DvT. Key takeaways from the …