Medicine and Health Sciences Commons^™

Lxr/Cd38 Activation Drives Cholesterol-Induced Macrophage Senescence And Neurodegeneration Via Nad+ Depletion, Ryo Terao, Tae Jun Lee, Jason Colasanti, Charles W Pfeifer, Joseph B Lin, Andrea Santeford, Keitaro Hase, Shinobu Yamaguchi, Daniel Du, Brian S Sohn, Yo Sasaki, Mitsukuni Yoshida, Rajendra S Apte

2020-Current year OA Pubs

Although dysregulated cholesterol metabolism predisposes aging tissues to inflammation and a plethora of diseases, the underlying molecular mechanism remains poorly defined. Here, we show that metabolic and genotoxic stresses, convergently acting through liver X nuclear receptor, upregulate CD38 to promote lysosomal cholesterol efflux, leading to nicotinamide adenine dinucleotide (NAD

Primary Care In The University Setting After Covid-19: A Multiple Case Study Of Student Health Services In Oregon, D. Chad Johnson

Dissertations and Theses

In 2020, the COVID-19 pandemic disrupted operations across the settings of primary care and higher education institutions (HEI). HEIs faced sudden decreases in revenue because of reduced enrollments and external pressures to rapidly adapt delivery methods to accommodate the inability to provide in-person classes. Similarly, most primary care settings experienced major reductions to in-person visits and fee-for-service revenues. Student health services (SHS) exist within both primary care and higher education settings and are a unique and poorly understood aspect of primary care. This research set out to explore this under-studied primary care setting by answering the question: "How has COVID-19 …

Psychological Safety Of Pre-Licensure Nursing Students: A Longitudinal, Qualitative Study, Laura Butler

Theses and Dissertations

Background: Previous studies have explored the concept of psychological safety among pre-licensure nursing students; however, the literature is notably sparse on personal descriptions of pre-licensure nursing students' experiences of psychological safety in clinical settings. Individual descriptions of psychological safety will provide added insight and understanding about the elements that shape psychological safety in pre-licensure nursing students. Objectives: This research aimed to longitudinally explore pre-licensure nursing students' experiences of psychological safety during clinical rotations and how their experiences of psychological safety change over time. Methods: This study used a longitudinal, qualitative, descriptive approach. Participants were recruited from a nursing program in …

Cosmetic Penile Enhancement Procedures: An Smsna Position Statement, Landon Trost, Daniel N Watter, Serge Carrier, Mohit Khera, Faysal A Yafi, Helen L Bernie, Matthew Ziegelmann, Tobias Köhler

Faculty, Staff and Students Publications

Background: Penile cosmetic enhancement procedures have been performed for many years with varying success. However, they have historically been relegated to niche areas of sexual medicine, with limited data, and have not achieved mainstream adoption. More recently, the topic has been increasingly discussed within academic congresses due to availability of novel techniques, therapies, and procedures. Given their distinctive nature, the Sexual Medicine Society of North America (SMSNA) felt that it was pertinent to develop formal position statements to help guide both patients and sexual medicine providers on the current state of the scientific literature and to give recommendations for future …

Factors Associated With Intention To Implement Sbi And Sud Treatment: A Survey Of Primary Care Clinicians In Texas Enrolled In An Online Course, Alicia Kowalchuk, Tiffany G Ostovar-Kermani, Kylie Schaper, Larissa Grigoryan, Jacqueline M Hirth, Maria Carmenza Mejia, Kiara K Spooner, Roger J Zoorob

Faculty, Staff and Students Publications

BACKGROUND: Substance use disorder (SUD) presents a range of public health challenges and consequences. Despite the prevention potential of screening and brief intervention (SBI) in the primary care setting, implementation is low. The purpose of this study was to assess associations of primary care clinicians' knowledge of SBI and SUD treatment, subjective norms, and perceived behavioral control with intention to incorporate SBI and SUD treatment into regular clinical practice.

METHODS: This online survey was administered to primary care clinicians who practice in Texas between March 1, 2021, and February 5, 2023. Survey questions were mapped to factors in the Theory …

A Technology-Assisted Web Application For Consumer Access To A Nonprescription Statin Medication, Steven E Nissen, Howard G Hutchinson, Kathy Wolski, Karol Watson, Seth S Martin, Erin D Michos, William S Weintraub, Melanie Morris, Leslie Cho, Luke Laffin, Douglas Jacoby, Christie M Ballantyne, Jan Ekelund, Filip Birve, Venu Menon, Michelle Strzelecki, Paul M Ridker

Faculty, Staff and Students Publications

Background: Although statins reduce adverse cardiovascular outcomes, less than one-half of eligible patients receive treatment. A nonprescription statin has the potential to improve access to statins.

Objectives: This study sought to assess concordance between clinician and consumer assessment of eligibility for nonprescription statin treatment using a technology assisted self-selection Web application (Web App) and evaluate effect on low-density lipoprotein cholesterol (LDL-C) levels.

Methods: This study was a prospective actual use 6-month study to evaluate use of a Web App to qualify participants without a medical background for a moderate-intensity statin based on current guidelines. Participants entered demographic information, cholesterol values, …

Compensation Between Foxp Transcription Factors Maintains Proper Striatal Function, Newaz I Ahmed, Nitin Khandelwal, Ashley G Anderson, Emily Oh, Rachael M Vollmer, Ashwinikumar Kulkarni, Jay R Gibson, Genevieve Konopka

Faculty, Staff and Students Publications

Spiny projection neurons (SPNs) of the striatum are critical in integrating neurochemical information to coordinate motor and reward-based behavior. Mutations in the regulatory transcription factors expressed in SPNs can result in neurodevelopmental disorders (NDDs). Paralogous transcription factors Foxp1 and Foxp2, which are both expressed in the dopamine receptor 1 (D1) expressing SPNs, are known to have variants implicated in NDDs. Utilizing mice with a D1-SPN-specific loss of Foxp1, Foxp2, or both and a combination of behavior, electrophysiology, and cell-type-specific genomic analysis, loss of both genes results in impaired motor and social behavior as well as increased firing of the D1-SPNs. …

Spontaneous Coronary Artery Dissection Outcomes Among Pregnant Vs. Non-Pregnant Women, Chayakrit Krittanawong, Neelkumar Patel, Dhrubajyoti Bandyopadhyay, Neil Sagar Maitra, Muzamil Khawaja, Zhen Wang, Mahboob Alam, Jacob Shani, Robert Frankel, Samin Sharma, Hani Jneid

Faculty, Staff and Students Publications

Aims: Spontaneous coronary artery dissection (SCAD) has become increasingly recognized. It accounts for < 1-4% of acute coronary syndrome presentations. Overall, however, it makes up over 40% of pregnancy-associated myocardial infarction. Furthermore, pregnancy-associated spontaneous coronary artery dissection (P-SCAD) is described to have a greater degree of clinical manifestations, including left ventricular dysfunction, shock, and left main or multivessel involvement. The findings are disconcerting, though many studies evaluating P-SCAD are based on case series data or are single centre studies.

Methods and results: The aim of this study was to evaluate a larger national dataset to evaluate the outcomes of SCAD and specifically P-SCAD in an attempt to better characterize the severity and clinical nature of this condition. To conduct this study, we analysed the National Readmission Database from January 2016 to December 2020. Propensity matching was done using the Greedy 1:1 method. Multivariate logistics and time-to-event Cox regression analysis models were built by including all confounders significantly associated with the outcome on univariable analysis with a …

Astrocytic Slc4a4 Regulates Blood-Brain Barrier Integrity In Healthy And Stroke Brains Via A Ccl2-Ccr2 Pathway And No Dysregulation, Qi Ye, Juyeon Jo, Chih-Yen Wang, Heavin Oh, Jiangshan Zhan, Tiffany J Choy, Kyoung In Kim, Angelo D'Alessandro, Yana K Reshetnyak, Sung Yun Jung, Zheng Chen, Sean P Marrelli, Hyun Kyoung Lee

Faculty, Staff and Student Publications

Astrocytes play vital roles in blood-brain barrier (BBB) maintenance, yet how they support BBB integrity under normal or pathological conditions remains poorly defined. Recent evidence suggests that ion homeostasis is a cellular mechanism important for BBB integrity. In the current study, we investigated the function of an astrocyte-specific pH regulator, Slc4a4, in BBB maintenance and repair. We show that astrocytic Slc4a4 is required for normal astrocyte morphological complexity and BBB function. Multi-omics analyses identified increased astrocytic secretion of CCL2 coupled with dysregulated arginine-NO metabolism after Slc4a4 deletion. Using a model of ischemic stroke, we found that loss of Slc4a4 exacerbates …

Pulmonary Hypertension And Hyperglycemia-Not A Sweet Combination, Or Bruck, L M Pandit

Faculty, Staff and Students Publications

Hyperglycemia and pulmonary hypertension (PH) share common pathological pathways that lead to vascular dysfunction and resultant cardiovascular complications. These shared pathologic pathways involve endothelial dysfunction, inflammation, oxidative stress, and hormonal imbalances. Individuals with hyperglycemia or pulmonary hypertension also possess shared clinical factors that contribute to increased morbidity from both diseases. This review aims to explore the relationship between PH and hyperglycemia, highlighting the mechanisms underlying their association and discussing the clinical implications. Understanding these common pathologic and clinical factors will enable early detection for those at-risk for complications from both diseases, paving the way for improved research and targeted therapeutics.

Retrospective Study On The Efficacy And Safety Of Dulaglutide In Patients With Diabetes And Moderate-Advanced Chronic Kidney Disease, Sriya Kosaraju, Rong M Zhang

2020-Current year OA Pubs

No abstract provided.

Induced Cd8Α Identifies Human Nk Cells With Enhanced Proliferative Fitness And Modulates Nk Cell Activation, Celia C. Cubitt, Pamela Wong, Hannah K. Dorando, Jennifer A. Foltz, Jennifer Tran, Lynne Marsala, Nancy D. Marin, Mark Foster, Timothy Schappe, Hijab Fatima, Michelle Becker-Hapak, Alice Y. Zhou, Kimberly Hwang, Miriam T. Jacobs, David A. Russler-Germain, Emily M. Mace, Melissa M. Berrien-Elliott, Jacqueline E. Payton, Todd A. Fehniger

2020-Current year OA Pubs

The surface receptor CD8α is present on 20%-80% of human (but not mouse) NK cells, yet its function on NK cells remains poorly understood. CD8α expression on donor NK cells was associated with a lack of therapeutic responses in patients with leukemia in prior studies, thus, we hypothesized that CD8α may affect critical NK cell functions. Here, we discovered that CD8α- NK cells had improved control of leukemia in xenograft models compared with CD8α+ NK cells, likely due to an enhanced capacity for proliferation. Unexpectedly, we found that CD8α expression was induced on approximately 30% of previously CD8α- NK cells …

Using Structured Problem Solving To Promote Fluid Consumption In The Prevention Of Urinary Stones With Hydration (Push) Trial, Peter P Reese, H Henry Lai, Alana C Desai, Et Al.

2020-Current year OA Pubs

BACKGROUND: Structured Problem Solving (SPS) is a patient-centered approach to promoting behavior change that relies on productive collaboration between coaches and participants and reinforces participant autonomy. We aimed to describe the design, implementation, and assessment of SPS in the multicenter Prevention of Urinary Stones with Hydration (PUSH) randomized trial.

METHODS: In the PUSH trial, individuals with a history of urinary stone disease and low urine output were randomized to control versus a multicomponent intervention including SPS that was designed to promote fluid consumption and thereby prevent recurrent stones. We provide details specifically about training and fidelity assessment of the SPS …

Nivolumab Plus Brentuximab Vedotin For Relapsed/Refractory Peripheral T-Cell Lymphoma And Cutaneous T-Cell Lymphoma, Pier Luigi Zinzani, Neha Mehta-Shah, Et Al.

2020-Current year OA Pubs

No abstract provided.

Safety And Efficacy Of Metabolic Modulation With Ninerafaxstat In Patients With Nonobstructive Hypertrophic Cardiomyopathy, Martin S Maron, Sharon Cresci, Et Al.

2020-Current year OA Pubs

BACKGROUND: In nonobstructive hypertrophic cardiomyopathy (nHCM), there are no approved medical therapies. Impaired myocardial energetics is a potential cause of symptoms and exercise limitation. Ninerafaxstat, a novel cardiac mitotrope, enhances cardiac energetics.

OBJECTIVES: This study sought to evaluate the safety and efficacy of ninerafaxstat in nHCM.

METHODS: Patients with hypertrophic cardiomyopathy and left ventricular outflow tract gradient < 30 mm Hg, ejection fraction ≥50%, and peak oxygen consumption < 80% predicted were randomized to ninerafaxstat 200 mg twice daily or placebo (1:1) for 12 weeks. The primary endpoint was safety and tolerability, with efficacy outcomes also assessed as secondary endpoints.

RESULTS: A total of 67 patients with nHCM were enrolled at 12 centers (57 ± 11.8 years of age; 55% women). Serious adverse events occurred in 11.8% (n = 4 of 34) in the ninerafaxstat group and 6.1% (n = 2 of 33) …

Success Of Early Childhood Caries After Treatment With Silver Diamine Fluoride Compared To Conventional Glass Ionomer Restoration. A Systematic Review, Sara H. Younis, Afnan M. Elkordy, Nouran M. Alshazly

Future Dental Journal

Abstract

Aim: To compare the success rate regarding esthetics, parenteral satisfaction, and oral health related quality of life (OHRQoL) after treatment of early childhood caries with Silver Diamine Fluoride (SDF)compared to conventional Glass ionomer Restoration (CGI).

Materials and Methods: We conducted a systematic review following PRISMA statement by searching on the following electronic databases: PubMed, Cochrane.

Results: From the studies included in this systematic review, two studies showed significant difference in color stability between SDF and CGI. Two studies showed no significant difference in parental satisfaction with either SDF or Glass Ionomer. Regarding the Oral Health Related Quality of Life, …

The Effect Of Preparation Design And Thermal Cycling On The Marginal Accuracy Of Hybrid Ceramic Laminate Veneers, Esraa El Bably, Ossama Saleh Abdelghany, Mostafa Aboushahba, Shereen Ahmed Nossair

Future Dental Journal

Aim: This study investigated the effect of preparation design and thermal cycling on the marginal accuracy of hybrid ceramic laminate veneers. Materials and Methods: A total of twenty 3D printed dies of central incisors prepared with 2 preparation designs; butt joint and palatal wrap design were fabricated. Each type of preparation was assigned into 2 subgroups (n=5/each subgroup) according to the type of material used for fabrication of the laminate veneer; hybrid ceramic and lithium disilicate (served as control). Marginal discrepancy was evaluated using a digital microscope before and after thermocycling. Results: Statistically analysis of marginal gaps revealed that before …

Radiographic Analysis Of Umbrella Technique Combined With Sticky Bone In Horizontal Ridge Augmentation, Ahmed Bahaa Zidan, Hala Kamal, Mohammed Wagdy

Future Dental Journal

Abstract:

Aim of the study: To evaluate the efficacy of umbrella technique combined with sticky bone in horizontal ridge augmentation using Buccolingual width changes measured in CBCT.

Materials and Methods: 15 male and female Patients were selected . Buccal and lingual Infiltration anaethesia to mandibular posterior area (area of interest), crestal incision flap. Decortication using round bur and straight hand piece then drilling using screw drills with 90 degrees to the buccal cotical plate. Umbrella Screw insertion using screw holder with 6 mm length and 1.6 mm diameter where 3 mm inserted in the bone and 3 mm are kept …

Evaluation Of Upper 1st Molar Rotation During Maxillary Canine Retraction In 1st Premolar Extraction Cases At 6 Weeks Reactivation Interval. A Clinical Trial., Rodayna A. Elbadawy, Kareem Elazab, Amr R. El-Beialy, Hend Salah

Future Dental Journal

Abstract:

Purpose: the aim of this clinical trial is to investigate maxillary first molar rotation during maxillary canine retraction at 6 weeks re-activation intervals with elastic power chain in first premolar extraction cases. Material and methods: a total of 20 quadrants of 10 orthodontic patients requiring maxillary canine retraction after extraction of upper 1^st premolars were recruited. Mini-screws (TADs) were used directly for maximum anchorage. Canines were retracted on 0.016×0.022-inch stainless steel arch wire using elastic power chain extending from a power arm on canine bracket to the miniscrew. Cone beam computed tomography (CBCT) was used to measure the …

Comparison Of Alignment Duration Between 0.018” And 0.022” Slot Brackets In Non-Extraction Orthodontic Adult Patients: (A Randomized Clinical Study), Omar Hazem Abouwafia, Hala Munir Abdel Majeed, Mona Salah Fayed, Nouran Fouad Seif-Eldin

Future Dental Journal

Abstract:

Introduction: Orthodontist tend to use one of the 2 bracket slot sizes available either the 0.018” or 0.022” bracket slot. Till now there is no reliable scientific evidence that indicates if any of them has a superior effect on the duration of teeth alignment. The aim of this study is to compare alignment duration between 0.018 and 0.022-inch bracket slot systems.

Subjects and methods: 14 Eligible participants having an age range of 14-22 years were randomly allocated to 2 groups (7 in each group). Group I: 0.018-inch and Group II: 0.022-inch slot (American orthodontics Mini master Roth prescription …

Effects Of Full-Time Versus Part-Time Clear Aligner Wear On Periodontal Health, Pain And Compliance In Orthodontic Patients, Mohamed Adel Afify, Ahmed Medhat Eltimamy, Fouad A. El Sharaby, Hala Monir Abdelmajeed

Future Dental Journal

INTRODUCTION: Clear aligner treatment's main drawback is that the patient decides how long to wear them each day. For clear aligner therapy to be successful, compliance is essential. A poor treatment outcome would arise from noncompliant patients.

METHODS: The study was a randomized clinical trial of 2 parallel groups (7 patients per group) who underwent clear aligner orthodontic treatment having an age range of 17-24 years. A part-time group wore the aligners for 16 hours per day and a full-time group wore the aligners for 22 hours per day. The study investigated the first eight aligners of the treatment. Compliance …

Comparison Between Orthodontic Measurements Taken From Cone-Beam Computed Tomography (Cbct) And Digital Models After Enmasse Retraction In Orthodontic Patients With Maxillary Protrusion., Amr M. Attia, Amr R. El-Beialy, Heba M. Dehis, Yehya A. Moustafa

Future Dental Journal

ABSTRACT

Objectives: This study aimed to evaluate the accuracy and reliability in measuring anchorage loss, molar rotation, and total amount of retraction using cone beam computed tomography (CBCT) and to compare them with the same measurements obtained using digitally scanned dental models. Materials and methods: 24 patients requiring comprehensive orthodontic treatment including extraction of 1st premolars with maximum anchorage using enmasse retraction. CBCTs were undertaken on the same 24 patients using InVivoDental software for measurement. The digital cast was made using alginate impressions, from which virtual 3D models will be created and measured using 3Shape analyzer software. Orthodontic measurements will …

Assessment Of Intra Operative Time For Computer Guided Posterior Mandible Onlay Grafting Versus Free Hand Onlay Grafting A Randamized Clinical Split Mouth Trial, Mahmoud Khorshed, Mohamed Mounir, Mohamed Atef, Yasmin Nassar

Future Dental Journal

Abstract

Purpose: The aim of this study was to evaluate the efficacy of onlay vertical bone augmentation using patient specific guide in the reduction of intra-operative time and postoperative pain compared to the free hand technique in the vertically deficient posterior mandible ridge using autogenous cortico-cancellous bone.

Methods: This study included 10 patients that had bilateral vertically deficient posterior mandibular alveolar ridges. For each patient, half of the ridge was augmented using 3D printed patient specific surgical guide for fixation of autogenous onlay bone graft, while the other half was augmented using free hand autogenous onlay bone graft technique using …

Measuring Accuracy Of Dolphin Imaging Software In Predicting Upper Jaw Soft Tissue Profile Changes In Class Ii Adult Patients Treated With Extraction Versus Non-Extraction., Amr Amin Arif, Esam Nasef, Amira Aboalnaga

Future Dental Journal

Abstract

Objective: To assess the accuracy of Dolphin Imaging software in predicting upper jaw profile changes in class II patients treated by extraction and non-extraction.

Methods: The records of 60 Class II div 1 patients were selected; 30 patients treated by extraction of upper first premolar and 30 patients treated by non-extraction. The Pre- and post-treatment lateral cephalometric x-rays of each patient were traced using Dolphin software. The actual hard tissue changes due to treatment were calculated and installed into the prediction module to generate the predicted profile. The soft tissue measurements of the actual post-treatment and predicted profiles were …

Smear Layer Removal Using Two Different Ni-Ti Instruments With Two Different Irrigating Systems. An Invitro Study, Tasneem Mohamed Reyad, Wael Ahmed Hessein, Ahmed Abdelrahman Hashem Ah, Said Abd Elhafiz

Future Dental Journal

Objectives: To evaluate and compare smear layer removal in root canals instrumented with two single Ni-Ti rotary instruments with two different irrigating systems. Materials and Methods: Sixty recently extracted single-rooted mandibular premolars teeth were decoronated to a standardized length of 14 mm. Roots were divided into two main groups (n=30) according to the rotary NiTi file used for instrumentation either with One Shape (OS) file or with One Curve file (OC). Each main group was subdivided into three subgroups according to the methods used to agitate the irrigating solutions either sonically or ultrasonically as following: Group A was subdivided into …

The Efficiency Of Passive Ultrasonic Activated Irrigation On The Retrievability Of Guttaflow Bioseal : In Vitro Study, Mohamed El Sayed Zaghloul, Tariq Yehia Abdelrahman Associate Professor, Maram Farouk Obeid Professor

Future Dental Journal

The efficiency of passive ultrasonic activated irrigation on the retrievability of Guttaflow Bioseal ( In Vitro Study )

Abstract:

Background: This study aimed to evaluate the efficiency of passive ultrasonic activated irrigation in the removal of GuttaFlow Bioseal root canal filling material during retreatment.

Materials and subjects: Root canals of thirty single-rooted human mandibular premolar teeth were prepared with ProTaper Universal rotary system and obturated with lateral condensation obturation technique using Gutta Percha and Roeko GuttaFlow Bioseal root canal sealer. All specimens were retreated with ProTaper Universal Retreatment System files then divided to two different groups according to the technique …

Effect Of Using Intracanal Cryotherapy Versus Ultrasonic Activated Irrigation On Post-Operative Pain In Single Visit Endodontic Treatment Of Teeth With Symptomatic Irreversible Pulpitis “Randomized Clinical Trial”, Marwa M. Hassan Elsherbeny, Essam Abdel Hafez Naguib E A Naguib, Reem Ahmed Lutfy Reem A. Lutfy, El Saeed Abdel Hafiz

Future Dental Journal

Aim : This study was designated to evaluate the effect of using intracanal cryotherapy versus ultrasonic activated irrigation on postoperative pain in single visit endodontic treatment of mandibular first molar with symptomatic, irreversible pulpitis using numerical rate scale (NRS) at 6, 12, 24, 48,72 hr and 1 week postoperatively.

Materials and Methods: seventy-eight patients diagnosed with symptomatic irreversible pulpitis in mandibular first molar with no periapical involvement. The cases were randomly divided into three groups according to final irrigation protocol after root canal preparation using Pro Taper Next; Groups A, B and C, twenty-six patients each group (n=26). Group A: …

A Cross – Sectional Observational Study On Pharmacoeconomics Burden Of Covid -19 In Ashmoun Fever Hospital Delta Egypt, Marwa Helmi Desouki, Marwa G. Elhennawy, Samar F. Farid

Bulletin of Faculty of Pharmacy Cairo University

Background: A wide range of respiratory illnesses like common colds, Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) are caused by coronaviruses.

In 2019 scientists in Wuhan, China discovered a new coronavirus (COVID-19). Unknown new coronavirus that infected people for the first time and causes losses for humans. It has caused a large number of deaths around the world and a greater number of injuries, and the countries of the world began to take measures and closures to confront the spread of this virus, and the economy was greatly affected.

Aim of Study: This study provides …

Echocardiographic Predictive Factors Of Worsening Outcome In Type 1 Cardiorenal Syndrome, Saoussen Antit, Sabrine Bousnina, Marwa Fathi, Ridha Fekih, Elhem Boussabeh, Lilia Zakhama

Journal of the Saudi Heart Association

Introduction: Type 1 cardiorenal syndrome (CRS) is defined as acute decompensated heart failure (AHF) leading to secondary acute kidney injury. Few studies have evaluated the reliability of transthoracic echocardiography (TTE) in assessing outcomes in patients with type 1 CRS. We sought to identify echocardiographic predictors of outcomes (death and rehospitalization) in patients with type 1 CRS. Methods: This was a prospective longitudinal monocentric study, conducted from December 2020 to December 2022 in the cardiology department of the Internal Security Forces Hospital in Marsa, Tunisia. 68 patients with type 1 CRS were included prospectively. Physical, biological, and echocardiographic data were collected …

Comparative Analysis Of Ultrasonographic Fetal Lung Texture In Twin And Singleton Fetuses, Nathan A. Keller, Luis A. Bracero, Christina Karras, Insaf Kouba, Frank Ian Jackson, Matthew J. Blitz, Sleiman R. Ghorayeb

Specialty Medicine Faculty Publications

Objectives: Increased fetal lung heterogeneity has been associated with term fetal lungs in singleton gestations. The objective of this study was to determine if fetal lung heterogeneity index (HI) differs between twin and singleton fetuses in the late second and third trimesters. Methods: Prospective cohort study of women with singleton and twin gestations with medically-indicated ultrasound examinations at 24 weeks of gestation onward. Grayscale transverse fetal lung images were obtained at the level of the four-chamber heart. A region of interest was selected in each fetal lung image. Fetal lung HI was determined with MATLAB software using a dithering technique …