Medicine and Health Sciences Commons^™

Efficacy And Safety Of Tepotinib In Asian Patients With Advanced Nsclc With Met Exon 14 Skipping Enrolled In Vision, Terufumi Kato, James Chih-Hsin Yang, Myung-Ju Ahn, Hiroshi Sakai, Masahiro Morise, Yuh-Min Chen, Ji-Youn Han, Jin-Ji Yang, Jun Zhao, Te-Chun Hsia, Karin Berghoff, Rolf Bruns, Helene Vioix, Simone Lang, Andreas Johne, Xiuning Le, Paul K Paik

Faculty, Staff and Student Publications

BACKGROUND: Tepotinib, a MET inhibitor approved for the treatment of MET exon 14 (METex14) skipping NSCLC, demonstrated durable clinical activity in VISION (Cohort A + C; N = 313): objective response rate (ORR) 51.4% (95% CI: 45.8, 57.1); median duration of response (mDOR) 18.0 months (95% CI: 12.4, 46.4). We report outcomes in Asian patients from VISION (Cohort A + C) (cut-off: November 20, 2022).

METHODS: Patients with advanced METex14 skipping NSCLC, detected by liquid or tissue biopsy, received tepotinib 500 mg (450 mg active moiety) once daily.

PRIMARY ENDPOINT: objective response (RECIST 1.1) by independent review. Secondary endpoints included: …

Effects Of Photobiomodulation Therapy On Muscle Function In Individuals With Multiple Sclerosis, Mitra Rouhani, Miguel Tolentino, Jeri-Anne Lyons, Alexander V. Ng

Exercise Science Faculty Research and Publications

Background

In people with multiple sclerosis (pwMS), muscle fatigue and weakness are common issues that can interfere with daily activities. Photobiomodulation therapy (PBMT), comprising light in a 600–1100 nm bandwidth, is a low-level laser therapy thought to improve muscle performance in non-disease populations, in part, by improving mitochondrial function and thus, might be beneficial in pwMS. Given this potential, we aimed to investigate the effects of PBMT on muscle performance in pwMS, both in the short-term and over an extended period.

Methods

This study consisted of two parts with a randomized double-blind crossover design. In study I, muscle function was …

Multi-Task Deep Neural Networks For Irregularly Sampled Multivariate Clinical Time Series, Yuxi Liu, Zhenhao Zhang, Shaowen Qin, Jiang Bian

Faculty, Staff and Student Publications

Multivariate clinical time series data, such as those contained in Electronic Health Records (EHR), often exhibit high levels of irregularity, notably, many missing values and varying time intervals. Existing methods usually construct deep neural network architectures that combine recurrent neural networks and time decay mechanisms to model variable correlations, impute missing values, and capture the impact of varying time intervals. The complete data matrices thus obtained from the imputation task are used for downstream risk prediction tasks. This study aims to achieve more desirable imputation and prediction accuracy by performing both tasks simultaneously. We present a new multi-task deep neural …

Life-Space Mobility, Transportation, And The Companionship Network Of Members Of A Hispanic Senior Center, Rebecca L Mauldin, Rupal Parekh, John P Connolly, Stephen P Mattingly, Aiman Mushtaq, Kayo Fujimoto

Faculty, Staff and Student Publications

Objectives: Companions (i.e., friends who spend time together) are important for the well-being of older adults. Senior centers in the United States are places for older adults to participate in group activities and form and maintain companionships. However, differences in mobility and transportation may affect the ability of older adults to leverage senior center activities into actual companionships.

Methods: This social network analysis was conducted to characterize the companionship network among members of a senior center in relation to their life-space mobility and transportation resources. An exponential random graph model was estimated to identify mobility- and transportation-related correlates of the …

Patient Location And Disparities In Access To Fertility Preservation For Women With Gynecologic Or Breast Cancer, Alexa Kanbergs, Kirsten Jorgensen, Nuria Agusti, David Viveros-Carreño, Chi-Fang Wu, Roni Nitecki, John A Harris, Terri Woodard, Ryan Ramphul, Jose Alejandro Rauh-Hain

Faculty, Staff and Student Publications

Objective: To assess the effect of geographic factors on fertility-sparing treatment or assisted reproductive technology (ART) utilization among women with gynecologic or breast cancers.

Methods: We conducted a cohort study of reproductive-aged patients (18-45 years) with early-stage cervical, endometrial, or ovarian cancer or stage I-III breast cancer diagnosed between January 2000 and December 2015 using linked data from the California Cancer Registry, the California Office of Statewide Health Planning and Development, and the Society for Assisted Reproductive Technology. Generalized linear mixed models were used to evaluate associations between distance from fertility and gynecologic oncology clinics, as well as California Healthy …

Correction: Contemporary Analysis Of Reexcision And Conversion To Mastectomy Rates And Associated Healthcare Costs For Women Undergoing Breast-Conserving Surgery, Youngran Kim, Cecilia Ganduglia-Cazaban, Nina Tamirisa, Anthony Lucci, Trudy Millard Krause

Faculty, Staff and Student Publications

Correction: Annals of Surgical Oncology 10.1245/s10434-024-14902-z

The article “Contemporary Analysis of Reexcision and Conversion to Mastectomy Rates and Associated Healthcare Costs for Women Undergoing Breast‑Conserving Surgery”, written by Kim et al. was originally published electronically on the publisher’s internet portal on February 6, 2024, without open access. With the authors‘ decision to opt for Open Choice the copyright of the article changed on March 14, 2024, to © The Author(s) 2024, and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long …

Time-To-Event Genome-Wide Association Study For Incident Cardiovascular Disease In People With Type 2 Diabetes, Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A Dicorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, Joann E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce Van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S De Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs

Faculty, Staff and Student Publications

Objective: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D).

Research design and methods: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD.

Results: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18.2%). We identified three novel genetic loci for incident CVD: rs147138607 (near CACNA1E/ZNF648, hazard ratio [HR] 1.23, P = 3.6 × 10-9), rs77142250 (near HS3ST1, HR 1.89, P = 9.9 × 10-9), and rs335407 (near …

Transformative Peer Connections: Early Experiences From The Asco Palliative Care Community Of Practice., Mazie Tsang, Cristiane Bergerot, Natasha Dhawan, Rushil Patel, Darcy Burbage, Tingting Zhang, Jafar Al-Mondhiry, Joseph Mccollom Do, Ramy Sedhom

PCI Publications and Projects

The integration of palliative care into routine oncology practice is the standard of care by most leading cancer organizations. Palliative medicine helps to deliver higher quality of care at a lower cost. However, there are barriers to implementing palliative oncology at many institutions for myriad reasons. In this article, we discuss an innovative strategy that ASCO implemented called the Communities of Practice (CoP). We share our experiences as the Palliative Care CoP and how our group seeks to develop processes and structures to collectively promote systemic change and enhance palliative care delivery for people with cancer. Our Palliative Care CoP …

Vestibular Correlates Of Cochlear Implantation, Danielle Lewis

Dissertations, Theses, and Capstone Projects

Previous research has illustrated that vestibular dysfunction is the most prevalent complication of cochlear implant (CI) surgery. There is substantial evidence of both short- and long-term vestibular dysfunction following CI surgery. The objective of this survey was to determine CI recipients’ expectation and satisfaction with their audiologists’ counseling regarding the possible vestibular effects of cochlear implantation. Survey participants included unilateral and bilateral adult CI recipients recruited through the NYC chapter of the Hearing Loss Association of America (HLAA), audiology-related Facebook groups, and Linked-In. The first 25 participants were offered a $20 Amazon gift card upon completion of the survey. The …

Development Of The Hearing Emotion/Activity Restrictions On Teenagers (Heart), Robin G. Axelrod

Dissertations, Theses, and Capstone Projects

DEVELOPMENT OF THE HEARING EMOTION/ ACTIVITY RESTRICTIONS ON TEENAGERS (HEART)

By: Robin Axelrod

Advisor: Barbara Weinstein

Background:

The Hearing Handicap Inventory for the Elderly is a self-assessment tool used to assess and quantify the impact of hearing loss on emotional and social wellness in the geriatric population. However, there is not an existing version for the teenage population. Hearing loss has the potential to impact social, emotional, and academic domains in the daily lives of teenagers with hearing loss. In this study, a new self-assessment tool called the Hearing Emotion/ Activity Restrictions on Teenagers (HEART) was created and distributed via …

Toolkit For Users Of Over-The-Counter Hearing Aids, Sabrina Malasarte

Dissertations, Theses, and Capstone Projects

Untreated hearing loss oftentimes has significant adverse effects on the quality of life of older adults. The associations include, but are not limited to loneliness, isolation, anxiety, and a decrease in cognitive function. Hearing aids significantly improve audibility, social interactions, and decrease feelings of loneliness or isolation. However, despite technological advances, and evidence of positive outcomes associated with hearing aid use, uptake and continued use of hearing aids remain low. Accessibility and affordability are considered barriers to uptake. Purchasing a prescription hearing aid from an audiologist is the traditional approach to receiving an amplification device, but the advent of over …

Failure To Mourn: Challenges To The Work Of Mourning In Twentieth-Century Italian Literature, Mattia Mossali

Dissertations, Theses, and Capstone Projects

This project brings together, in a novel combination and through a comparative and transnational perspective, three Italian authors from the Twentieth century who around the same years have produced texts in an effort to verbalize the pain caused by the loss of a loved one: Gina Lagorio (1922-2005), Lalla Romano (1906-2001), and Pier Vittorio Tondelli (1955-1991). Through a variety of literary forms, from fictional self-representations in “autobiographical” novels to the desire for authenticity that characterizes so-called grief memoirs, each of them confronts the challenge of how to write about the deeply painful experience of mourning. After witnessing death, they look …

Lymphovenous Anastomosis For The External And Internal Types Of Head And Neck Lymphedema: A Case Series And Preliminary Clinical Results, Ying-Sheng Lin, Chia-Ju Liu, Chen-Han Chou

Faculty, Staff and Student Publications

BACKGROUND: Head and neck lymphedema (HNL), including external and internal types, could be a possible consequence for patients who have received neck dissection and radiotherapy for head and neck cancer. Initially, the common presentations are heaviness or tightness, followed by swelling in appearance, or difficulty speaking and swallowing in internal edema cases. Lymphovenous anastomosis (LVA) is an established approach to treat extremity lymphedema. We hereby present our preliminary experience in using LVA to treat HNL.

METHODS: Between March 2021 and January 2024, six patients with HNL were treated with LVA via a preauricular or submandibular incision of the obstructed side. …

Genome-Wide Interaction Study Of Dietary Intake Of Fibre, Fruits, And Vegetables With Risk Of Colorectal Cancer, Nikos Papadimitriou, Andre Kim, Eric S Kawaguchi, John Morrison, Virginia Diez-Obrero, Demetrius Albanes, Sonja I Berndt, Stéphane Bézieau, Stephanie A Bien, D Timothy Bishop, Emmanouil Bouras, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Robert Carreras-Torres, Andrew T Chan, Jenny Chang-Claude, David V Conti, Matthew A Devall, Niki Dimou, David A Drew, Stephen B Gruber, Tabitha A Harrison, Michael Hoffmeister, Jeroen R Huyghe, Amit D Joshi, Temitope O Keku, Anshul Kundaje, Sébastien Küry, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Brigid M Lynch, Victor Moreno, Christina C Newton, Mireia Obón-Santacana, Jennifer Ose, Andrew J Pellatt, Anita R Peoples, Elizabeth A Platz, Conghui Qu, Gad Rennert, Edward Ruiz-Narvaez, Anna Shcherbina, Mariana C Stern, Yu-Ru Su, Duncan C Thomas, Claire E Thomas, Yu Tian, Konstantinos K Tsilidis, Cornelia M Ulrich, Caroline Y Um, Kala Visvanathan, Jun Wang, Emily White, Michael O Woods, Stephanie L Schmit, Finlay Macrae, John D Potter, John L Hopper, Ulrike Peters, Neil Murphy, Li Hsu, Marc J Gunter, W James Gauderman

Faculty, Staff and Student Publications

Background: Consumption of fibre, fruits and vegetables have been linked with lower colorectal cancer (CRC) risk. A genome-wide gene-environment (G × E) analysis was performed to test whether genetic variants modify these associations.

Methods: A pooled sample of 45 studies including up to 69,734 participants (cases: 29,896; controls: 39,838) of European ancestry were included. To identify G × E interactions, we used the traditional 1--degree-of-freedom (DF) G × E test and to improve power a 2-step procedure and a 3DF joint test that investigates the association between a genetic variant and dietary exposure, CRC risk and G × E interaction …

Risk-Benefit Trade-Offs And Precision Utilities In Phase I-Ii Clinical Trials, Pavlos Msaouel, Juhee Lee, Peter F Thall

Faculty, Staff and Student Publications

Background: Identifying optimal doses in early-phase clinical trials is critically important. Therapies administered at doses that are either unsafe or biologically ineffective are unlikely to be successful in subsequent clinical trials or to obtain regulatory approval. Identifying appropriate doses for new agents is a complex process that involves balancing the risks and benefits of outcomes such as biological efficacy, toxicity, and patient quality of life.

Purpose: While conventional phase I trials rely solely on toxicity to determine doses, phase I-II trials explicitly account for both efficacy and toxicity, which enables them to identify doses that provide the most favorable risk-benefit …

High Community-Level Social Vulnerability Is Associated With Worse Recurrence-Free Survival (Rfs) After Resection Of Extremity And Truncal Soft Tissue Sarcoma, Raymond S Traweek, Heather G Lyu, Russell G Witt, Rebecca A Snyder, Elise F Nassif, David D Krijgh, Jeffrey M Smith, Gordon S Tilney, Chun Feng, Yi-Ju Chiang, Keila E Torres, Margaret J Roubaud, Christopher P Scally, Kelly K Hunt, Emily Z Keung, Alexander F Mericli, Christina L Roland

Faculty, Staff and Student Publications

Background: Although social vulnerability has been associated with worse postoperative and oncologic outcomes in other cancer types, these effects have not been characterized in patients with soft tissue sarcoma. This study evaluated the association of social vulnerability and oncologic outcomes.

Methods: The authors conducted a single-institution cohort study of adult patients with primary and locally recurrent extremity or truncal soft tissue sarcoma undergoing resection between January 2016 and December 2021. The social vulnerability index (SVI) was measured on a low (SVI 1-39%, least vulnerable) to high (60-100%, most vulnerable) SVI scale. The association of SVI with overall survival (OS) and …

Omicsmic: A Comprehensive Benchmarking Platform For Robust Comparison Of Imputation Methods In Mass Spectrometry-Based Omics Data, Weiqiang Lin, Jiadong Ji, Kuan-Jui Su, Chuan Qiu, Qing Tian, Lan-Juan Zhao, Zhe Luo, Chong Wu, Hui Shen, Hongwen Deng

Faculty, Staff and Student Publications

Mass spectrometry is a powerful and widely used tool for generating proteomics, lipidomics and metabolomics profiles, which is pivotal for elucidating biological processes and identifying biomarkers. However, missing values in mass spectrometry-based omics data may pose a critical challenge for the comprehensive identification of biomarkers and elucidation of the biological processes underlying human complex disorders. To alleviate this issue, various imputation methods for mass spectrometry-based omics data have been developed. However, a comprehensive comparison of these imputation methods is still lacking, and researchers are frequently confronted with a multitude of options without a clear rationale for method selection. To address …

Red Raspberries Attenuate Blood Glucose Spike Of A High Glycemic Load Breakfast Cereal, Dante J. Martin

Master's Theses

Blood glucose (BG) spikes increase chronic disease risk in those with and without diabetes. The fiber and phytonutrient content of fruit, such as raspberries has the potential to attenuate the BG spike of a high glycemic load (HGL) meal. We examined the effect of red raspberries (RRs) on the BG spike when added to a HGL meal. In this randomized cross-over trial, 16 university students were given breakfast cereal and almond milk (control), the control breakfast with 140g added RRs, and the control breakfast with sugar equivalent to the sugar content of the RRs (50% sugar increase from control). Meals …

Deciphering The Contribution Of Microglia To Neurodegeneration In Friedreich's Ataxia, Sydney N. Gillette

Master's Theses

Friedreich's ataxia (FRDA) is the most prevalent inherited ataxia, affecting one in every 50,000 individuals in the United States. This hereditary condition is caused by an abnormal GAA trinucleotide repeat expansion within the first intron of the frataxin gene resulting in decreased levels of the frataxin protein (FXN). Insufficient cellular frataxin levels results in iron accumulation, increased reactive oxygen species production and mitochondrial dysfunction. Tissues most heavily impacted are those most dependent on oxidative phosphorylation as an energy source and include the nervous system and muscle tissue. This is evident in the clinical phenotype which includes muscle weakness, ataxia, neurodegeneration …

Naturify 2300, Yarina Yiwei Dai

Masters Theses

In my art practice, I explore the interplay between human desires to manipulate and anthropomorphize nature, as seen in the technological augmentation of plants and living entities. This investigation delves into how this intersection, alongside empathy towards these creations, contributes to fears of uncontrollability and the risks of addiction and excessive dependence on technology.

Bioengineering and genetic modification have cultivated unprecedented developments, allowing humans to manipulate the fundamental building blocks of life. My research speculates on this technology further, modifying the genetic code of organisms and creating bioengineered wearable entities with enhanced traits or entirely new functionalities. The primary objective …

Guilty Pleasure: Women's Perception Of Health, Body Image, And Femininity, Irene *Yi-Han Chung

Masters Theses

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Safety And Prescribing Recommendations For Verapamil In Newly Diagnosed Pediatric Type 1 Diabetes (T1d): The Clver Experience., Laya Ekhlaspour, Bruce Buckingham, Colleen Bauza, Mark A. Clements, Gregory P. Forlenza, Anna Neyman, Lisa Norlander, Marcus Schamberger, Jennifer L. Sherr, Ryan Bailey, Roy W. Beck, Craig Kollman, Shannon Beasley, Erin Cobry, Linda A. Dimeglio, Emily Paprocki, Michelle Van Name, Antoinette Moran, Clver Study Group

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: To report the safety and side effects associated with taking verapamil for beta-cell preservation in children with newly-diagnosed T1D.

RESEARCH DESIGN AND METHODS: Eighty-eight participants aged 8.5 to 17.9 years weighing ≥ 30 kg were randomly assigned to verapamil (N = 47) or placebo (N = 41) within 31 days of T1D diagnosis and followed for 12 months from diagnosis, main CLVer study. Drug dosing was weight-based with incremental increases to full dosage. Side effect monitoring included serial measurements of pulse, blood pressure, liver enzymes, and electrocardiograms (ECGs). At study end, participants were enrolled in an observational extension study …

A Comparison Of Temporary Threshold Shifts In Dentists, Hygienists, And Dental Assistants, Sabina E. Ciaccio

Dissertations, Theses, and Capstone Projects

Objective: The purpose of this study is to compare the temporary threshold shifts (TTS) in dentists, hygienists, and dental assistants. The specific aim of this study is to compare the differences in temporary shifts caused by the different dental equipment and the proximity to the equipment. The current literature does not compare the change in hearing thresholds of dental personnel.

Methods: Dentists, dental assistants, and hygienists from Hermann Dental Associates will be given a case history form to determine inclusion status for this study. Exclusion criteria will include known hearing loss and significant noise exposure the day prior. …

Polarization, The Pandemic, And Public Trust In Health System Actors, Alessandro Del Ponte, Alan S. Gerber, Eric M. Patashnik

Political Science Faculty Articles and Research

Context: Public opinion on the performance of health system actors is polarized today, but it remains unclear which actors enjoy the most or the least trust among Democrats and Republicans, whether the COVID-19 pandemic has influenced how people view their own physicians, and whether doctors have retained the ability to influence public beliefs about policy issues.

Methods: The authors conducted two national surveys in 2022 and 2023 to examine these questions.

Findings: Democrats rated the performance of medical research scientists and public health experts during the pandemic more highly than did Republicans and independents. About three in ten Republicans said …

Scaling Antimicrobial Resistance Surveillance Nationally: The Case Of The Fleming Fund In Kenya, Mitchelle Kasudi, Dishon Muloi, Murungi Maurice, Allan Azegele, Romona Ndanyi, Revathi Gunturu, Loice Ombajo, Emmanuel Tanui, Robert Onsare, Geoffrey Omuse

Pathology, East Africa

Rising levels of antimicrobial resistance (AMR) in both humans and animals have reached alarming levels and are being recognized as a serious incremental threat to global food security, animal health and public health. The One Health approach recognizes the interconnectedness of human, animal and environmental health, and that AMR can be spread between different species and environments. The Fleming Fund, a UK Overseas Development Aid program managed by the UK’s Department of Health and Social Care, aims to improve AMR and antimicrobial use (AMU) surveillance data in Africa and Asia by generating, sharing, and using data to improve antimicrobial use …

Fine-Grained Patient Similarity Measuring Using Contrastive Graph Similarity Networks, Yuxi Liu, Zhenhao Zhang, Shaowen Qin, Flora D Salim, Jiang Bian, Antonio Jimeno Yepes

Faculty, Staff and Student Publications

Predictive analytics using Electronic Health Records (EHRs) have become an active research area in recent years, especially with the development of deep learning techniques. A popular EHR data analysis paradigm in deep learning is patient representation learning, which aims to learn a condensed mathematical representation of individual patients. However, EHR data are often inherently irregular, i.e., data entries were captured at different times as well as with different contents due to the individualized needs of each patient. Most of the work focused on the provision of deep neural networks with attention mechanisms that generate complete patient representations that can be …

An Ethical Approach To Genomic Privacy Preserving Technology Development, Lynette Hammond Gerido, Erman Ayday

Faculty, Staff and Student Publications

Demand for genomic research data and genetic testing results from cancer patients has grown exponentially. When a patient is diagnosed with a hereditary cancer syndrome, standard practice is for providers to encourage patients to discuss their results with their relatives and encourage those relatives to have clinical genetic testing and possibly participate in genetic research. Genomic research data and genetic testing results are being shared and connected in ways never imagined. Genomic data sharing is critical for advancing precision health and increasing diversity in global genome databases. However, these advancements often come with undesirable consequences, which call for additional privacy …

Evaluating Generative Models In Medical Imaging, Liyue Fan, Ashley Bang, Luca Bonomi

Faculty, Staff and Student Publications

Data synthesis can address important data availability challenges in biomedical informatics. Quantitative evaluation of generative models may help understand their applications to synthesizing biomedical data. This poster paper examines state-of-the-art generative models used in medical imaging, such as StyleGAN and DDPM models, and evaluates their performance in learning data manifolds and in the visible features of generated samples. Results show that existing generative models have much to improve based on the studied measures.

Stratification Of Glioma Based On Stemness Scores In Bulk And Single-Cell Transcriptomes, Zeinab Abdelrahman, Alaa Abdelatty, Jiangti Luo, Amy Jayne Mcknight, Xiaosheng Wang

Faculty, Staff and Student Publications

Background: Brain tumours are known to have a high mortality and morbidity rate due to their localised and frequent invasive growth. The concept that glioma resistance could originate from the dissimilarity in the vulnerability of clonogenic glial stem cells to chemotherapeutic drugs and radiation has driven the scientific community to reexamine the comprehension of glioma growth and strategies that target these cells or modify their stemness.

Methods: Based on the enrichment scores of 12 stemness signatures, we identified glioma subtypes in both tumour bulks and single cells by clustering analysis. Furthermore, we comprehensively compared molecular and clinical features among the …

Us Filipino Adults Have Elevated Prevalence Of Hypertension Across The Adult Lifespan: Findings From A Cross-Sectional Electronic Health Record Study, Nancy P Gordon, Irvin C Lien, Jamal S Rana, Joan C Lo

Faculty, Staff and Student Publications

INTRODUCTION: The prevalence of hypertension increases with age and differs by race and ethnicity. Among U.S. Asian adults, prevalence is higher for Filipino adults than for other major Asian subgroups, but whether this disparity exists across the adult lifespan is unknown. This study examined hypertension prevalence by age decade, comparing Filipino adults with South Asian, Chinese, Black, Hispanic, and White adults.

METHODS: This cross-sectional study used 2015-2016 electronic health record data from a Northern California integrated healthcare delivery system for 1,839,603 adults aged 30-79 years, including 128,124 Filipino adults. Hypertension was defined by diagnosis codes. Sex-specific prevalence was calculated by …