Medicine and Health Sciences Commons^™

Differential Expression Of Wnt5a Long And Short Isoforms In Non-Muscle-Invasive Bladder Urothelial Carcinoma., Amy M Strope, Cody Phillips, Sabin Khadgi, Scott A Jenkinson, Karen T Coschigano, Ramiro Malgor

Oncology Articles

Wnt ligands belong to a family of secreted glycoproteins in which binding to a range of receptors/co-receptors activates several intracellular pathways. WNT5A, a member of the Wnt family, is classified as a non-canonical Wnt whose activation triggers planar cell polarity (PCP) and Ca+2 downstream pathways. Aberrant expression of WNT5A has been shown to play both protective and harmful roles in an array of conditions, such as inflammatory disease and cancer. In the present study, using histological, immunohistochemical, and molecular methods, we investigated the expression of two isoforms of WNT5A, WNT5A-Short (WNT5A-S) and WNT5A-Long (WNT5A-L) in bladder urothelial carcinoma (UC). Three …

Post Hoc Analysis Of Daratumumab Plus Lenalidomide, Bortezomib And Dexamethasone In Black Patients From Final Data Of The Griffin Study., Ajay K Nooka, Jonathan L Kaufman, Cesar Rodriguez, Andrzej Jakubowiak, Yvonne Efebera, Brandi Reeves, Tanya M Wildes, Sarah A Holstein, Larry D Anderson, Ashraf Badros, Leyla Shune, Ajai Chari, Huiling Pei, Annelore Cortoos, Sharmila Patel, Thomas S Lin, Peter M Voorhees, Saad Z Usmani, Paul G Richardson

Oncology Articles

Due in part to racial disparities and underrepresentation in clinical studies, optimal therapies for Black patients with multiple myeloma remain undefined. This final analysis of GRIFFIN by race showed that the addition of daratumumab (D) to lenalidomide/bortezomib/dexamethasone (RVd) provides clinical benefit among both Black and White transplant-eligible newly diagnosed patients compared with RVd alone. However, Black patients were more likely to discontinue ≥1 drug due to treatment-emergent adverse events. In summary, these findings suggest a benefit of D-RVd front-line therapy among Black and White patients and underscore the importance of equitable treatment access for all patients.

Thematic Analysis Of Using Visual Methods To Understand Healthcare Teams, Muhammad Faisal Ahmed, Konain Ali, Muskaan Mann, Shannon L. Sibbald

Health Studies Publications

In healthcare, teams are essential in solving today’s toughest challenges. However, narrow disciplinary perspectives have limited our current understanding of how teams function in various healthcare contexts. Researchers often rely on traditional survey methods as their primary tool, which can prevent them from gathering comprehensive data. To overcome this limitation, sharing stories and narratives visually allows participants to create representations of their perceptions of team experiences and complex encounters using a variety of approaches. Despite the potential of this method, there is little empirical guidance on how to use it in health sciences research. To address this gap and provide …

No Longer Npo At Midnight For Heart Catheterizations, Danica Brassbridge Rn, Bsn, Jessica Creelman Rn, Bsn, Dominique Smith Rn, Bsn

Nurse Residency

Does keeping cardiac catheterization patients NPO at midnight significantly reduce their adverse outcomes compared to those who are able to have clear liquids four hours pre procedure?

Oral Care And Oral Hygiene, Margaret Yenna Rn, Bsn, Shelby Morin Rn, Bsn

Nurse Residency

In adults hospitalized oncology patients undergoing medical care, does doing oral care reduce incidents with oral complication compared to those who do not receive mouth care?

Effect Of Stop-Cocks In Reducing Post-Procedure Femoral Access Complications, Alessia Toohey Rn, Ross Underwood Rn, Clare Zorena Rn

Nurse Residency

n patients undergoing cardiac procedures requiring femoral artery access, does the use of stop-cocks with figure-8 stitches in femoral access closure compared to standard closure methods without these techniques reduce the incidence of post-procedure complications such as bleeding and hematoma within 24 to 48 hours post procedure?

Mental Health Interventions For The High-Risk Antepartum Inpatient Population, Mary Halle Bsn, Rn

Nurse Residency

In the high-risk antepartum patient population, do tailored mental health interventions, compared to routine intervention, improve patients’ overall mental well-being during inpatient hospitalization?

Impact Of Gum Chewing On Return Of Gastrointestinal Motility In Postoperative Colorectal Surgery Patients, Cheryl Kaufman Rn

Nurse Residency

PICOT Question: In postoperative colorectal surgery patients, how does gum chewing versus non-gum chewing beginning post op day one impact the return of gastric motility and the prevention of postoperative ileus?

Use Of Sat/Sbt In Adult Critical Care, Jack Shibles Rn, Kelsie Lynch Rn, Grace Decker Rn, Matthew Mcdonald Rn

Nurse Residency

In mechanically ventilated adult Intensive Care Unit (ICU) patients, how does having a protocol for pairing a spontaneous breathing trial (SBT) with a spontaneous awakening trial (SAT) compared to not having a protocol affect the number of ventilator days?

Trauma-Informed Care For Nicu Parents, Emma Stahl Bsn Rn, Elise Tilton Bsn Rn

Nurse Residency

For parents of neonates that have been admitted to the NICU, does the use of trauma-informed care reduce the risk of parental stress/ trauma?

Shared Decision Making: The Importance Of Communicating With Guardians And Pediatric Patients, Kali Coyne Rn, Bsn, Kaitlynn Hutchins Rn, Bsn, Alyssa Albert Rn, Bsn, Katy Ray Rn, Bsn

Nurse Residency

In pediatric patient who visit the emergency room, is including the child in shared decision making compared to having the parent be the surrogate decision maker more beneficial to the experience and satisfaction of the family?

Who Should Pay The Bill For The Mental Health Crisis In Africa?, Cyprian Mostert, Olivera Nesic Taylor,, Chinedu Momoh, Murad M. Khan Dr., Thomas Thesen, Edna Bosire, Dominic Trepel, Karen Blackmon, Manasi Kumar, Zul Merali

Brain and Mind Institute

No abstract provided.

The Field Of Interventional Neurology (In) In Pakistan: Scope And Challenges, Ahmed Wali

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

A Rare Presentation Of Brain Cystic Disease Linked With Ectodermal Dysplasia (Cerebrum Polycystica Vera): A Novel Neurocutaneous Syndrome, Sana Ghous, Alam Ibrahim Siddiqui, Abdul Rahman Soomro, Anjlee Shankar, Asif Ali, Shaheen Bhatty

Pakistan Journal of Neurological Sciences (PJNS)

Neurocutaneous syndromes comprise a diverse group of conditions affecting both the nervous system and the integumentary system. Within this spectrum, we present a rare and compelling case of cerebrum polycystica vera associated with ectodermal dysplasia in a 30-year-old male. The patient's clinical journey includes a sequence of seizures progressing to left-sided weakness, accompanied by compelling dermatological manifestations. Extensive neuroimaging studies, including MRI and CT scans, reveal the presence of multiple cysts in the brain, highlighting the distinct nature of this novel neurocutaneous syndrome. Based on the authors’ knowledge, this represents the first documented case report from Pakistan, while a few …

Recurrent Intraosseous Myxoma: A Case Report, Alma Corazon T De La Cruz, Michael N Sabalza

Pakistan Journal of Neurological Sciences (PJNS)

Myxomas are rare, benign but locally aggressive neoplasms that are of mesenchymal origin. These tumors are usually diagnosed only when they have grown enough to cause symptoms because of their indolent nature, hence imaging plays a large role in the diagnosis of these tumors. Imaging findings may include well-circumscribed multinodular masses with destruction of adjacent bony structures. Treatment of these tumors is complete resection and close follow up. Early recognition with physical examination and imaging studies, close follow up and multidisciplinary treatment are needed to achieve the best results for patients. We present a 34-year-old male who presented with proptosis …

Video Gaming Addiction In Pakistani Adolescents: A Growing Concern, Hamza Imran, Batool Mujtaba, Hamza Waheed, Muhammad Ibrahim

Pakistan Journal of Neurological Sciences (PJNS)

Background and objective: Video game addiction, or gaming disorder, is marked by impaired control over gaming, prioritizing gaming over other activities, and continuing despite negative consequences. This can lead to psychological, social, and occupational impairments. Despite its high prevalence among adolescents, research in Pakistan is limited. This review aims to compare international research on video game addiction and raise awareness about its impact on Pakistani adolescents.

Methods: Using the PubMed, Google Scholar, and Cochrane databases, a thorough literature search was carried out to find research on video game addiction among teenagers in Pakistan, the USA, Canada, India, and China, aged …

Treatment And Outcome Of Non-Convulsive Status Epilepticus In Children: A Cross-Sectional Study, Shaila Ali, Natasha Ghani, Tipu Sultan

Pakistan Journal of Neurological Sciences (PJNS)

Background and objective: Incidence and prevalence of non-convulsive status epilepticus is difficult to know, especially in developing countries where access to diagnostic tools like EEG is limited. The objective of this study was to determine the treatment and outcome of non-convulsive status epilepticus in children.

Methods: A total of 38 children were included in this prospective cross-sectional study, having EEG suggestive of non-convulsive status epilepticus. Response of the treatment given was measured by doing EEG after treatment to see resolution of non-convulsive status and improvement in clinical features too. Outcome was also assessed in terms of morbidity and mortality. The …

Causes And Presentations Of Bilateral Thalamic Lesions: A Retrospective Cross-Sectional Study From A Tertiary Care Hospital, Shafaq Saleem, Muhammad Saleem, Fatima Mubarak, Salman Farooq

Pakistan Journal of Neurological Sciences (PJNS)

Background and objective: Bilateral thalamic lesions present a significant diagnostic and therapeutic challenge due to their critical role in sensory, motor, and cognitive functions. The objective of this study was to study the causes and presentations of bilateral thalamic lesions among patients presenting to a tertiary care hospital. Methods: This retrospective study reviewed 40 patients aged 18–80 years admitted to Aga Khan University Hospital between 2006 and 2023 with MRI-confirmed bilateral thalamic lesions. Data collected included demographics, clinical presentations, radiological findings, and final diagnoses. The data was analyzed through SPSS 22.0.

Results: Of the 40 cases analyzed, the most common …

Gender Differences In Risk Factor Profiles And Predictors Of Poor Outcomes Among Acute Stroke Patients: A Pilot Study From Egypt, Ahmed Abualhasan, Foad Abd-Allah, Sahar Salaheldin, Enas Alsayyad

Pakistan Journal of Neurological Sciences (PJNS)

Background and objective: Stroke remains a leading cause of mortality and long-term disability worldwide, with significant socioeconomic implications. This study aimed to investigate gender-based differences in acute stroke patients regarding baseline characteristics, clinical presentation, and predictors of poor outcome Among Egyptian population.

Methods: We prospectively recruited 116 acute stroke patients admitted to the stroke unit at Cairo University Hospitals from January 2020 to June 2020. Detailed data on demographics, clinical characteristics, diagnostic workup, hospital course, and functional outcomes were collected. Poor outcome was defined as a modified Rankin Scale (mRS) ≥ 3 at discharge. Data were analyzed using SPSS version …

Frequency And Severity Of Cow’S Milk Allergy Reactions In Children: A Prospective Audit, Loise Wang'ondu, Enock Topisia

Paediatrics and Child Health, East Africa

Milk ranks as the second most common allergen, following peanuts. Recent studies from Spain and the
USA reports an annual frequency of accidental allergic reactions (AAR) ranging from 34% to 40%. AAR severity is influenced by food allergens and the presence of atopic diseases such as asthma, eczema, hay-fever, and recurrent wheezing. This study aimed to determine the frequency of accidental allergic reactions in children with cow’s milk protein allergy between September 2011 to September 2012. The study design employed is missing. A structured questionnaire was used and the guardians of the patients were guided in answering by the research …

Disparities In Birth Outcomes Within The U.S. White Population: Prevalence Of Low Birth Weight Among Immigrant Mothers From The Middle East And North Africa, Leila Moustafa, Patricia Mcgaughey, Tod G. Hamilton

School of Nursing Faculty Scholarship and Creative Works

Immigration from the Middle East and North Africa (MENA) has diversified the U.S. non-Hispanic White population. Analyzing health disparities within this group is a complex task due to data limitations across most federal and state data collection systems. This study investigates disparities in the risk of giving birth to a low-birth-weight infant among foreign-born non-Hispanic White MENA and non-MENA mothers and by MENA mothers’ nationality. This population-based study uses Restricted-Use Detail Natality Data from 2016 to 2019 accessed through the National Center for Health Statistics and provided by the Centers for Disease Control and Prevention. The study examines the …

Insights Into The Influence Of Income Variability On Cardiovascular Risk In Non-Elderly Adults With Type 2 Diabetes, Ketrell Mcwhorter

UK CARES Faculty Publications

No abstract provided.

Nursing News & Views - June 2024, Joanne Miller Rn

Nursing Newsletters

Nursing News & Views Newsletter - June 2024

A Retrospective Review: Oxford County Wellness Collaborative's Contributions To Community Health, Emma Schwartz, Rachel M. Gallo Mph

Children, Youth, & Families

Since 2011, Oxford County Wellness Collaborative (OCWC) has been transforming personal, environmental, and economic health by building strong relationships among people and organizations. OCWC contracted with the Data Innovation Project at the Catherine Cutler Institute of Health and Social Policy to synthesize previously collected or reported data and collect primary data to conduct a retrospective evaluation. The evaluation team used this data to convey past successes, better understand the outcomes of the collaborative to date, and provide recommendations for OCWC’s next steps in furthering its impact.

Denver: A Love Story - Why Dentists Love The Mile High City, Jack Nguyen Ms, Dds

Metro Denver Dental Society Articulator Magazine

This article explores the reasons why dentists are drawn to the Denver metro area. Highlighting factors such as climate, lifestyle, family-friendly amenities, thriving economic opportunities and community connectivity, it showcases diverse perspectives from dental professionals who have chosen to establish their careers and lives in Colorado's capital city.

Management Of Dysphagia In Tracheostomized Patients: A Narrative Review, Chih-En Liu, Shu-Mei Yang, Ming-Yen Hsiao

Rehabilitation Practice and Science

Swallowing disorders are prevalent in tracheostomized patients and are associated with a high incidence of aspiration. This narrative review discusses the primary causes and subsequent management strategies for dysphagia in this population. Factors such as reduced laryngeal elevation, compromised hypopharyngeal and laryngeal sensations, impaired vocal cord function, loss of glottic airflow and subglottic pressure, weakened cough reflex, increased respiratory secretions, and disuse muscle atrophy have been identified as major contributors. These challenges can lead to severe complications, including aspiration pneumonia and respiratory failure. Comprehensive evaluations that combine clinical assessments with a thorough review of a patient’s medical history are crucial. …

Pseudomeningocele Following Traumatic Brachial Plexus Injury: A Case Report, Shih-Ting Huang, Ming-Hsun Lee, Simon-Fuk Tan Tang, Ching-Yu Wang, Yu-Ting Hsieh

Rehabilitation Practice and Science

An injury to the brachial plexus can lead to the development of a pseudomeningocele, a buildup of cerebrospinal fluid (CSF) in the subarachnoid space caused by tears in the affected root sleeves. External forces acting on the brachial plexus represent the main mechanism of injury. The resulting stretching and tearing of the meninges outside the nerve root led to the pseudomeningocele. Although often initially asymptomatic, a pseudomeningocele can eventually cause pain, paresthesia, muscle weakness, and paralysis. The nerve conduction studies (NCS), electromyography (EMG), and magnetic resonance imaging (MRI) can be used to identify the injury, and treatment can involve either …

Articulator Q2 2024

Metro Denver Dental Society Articulator Magazine

The MDDS Articulator magazine has been serving as the voice for Denver's dental community for over 100 years.

Distributed to approximately 2,000 dental professionals quarterly, the Articulator features local news, industry trends, practice management guidance, data-driven research and more. The award-winning publication is available to member dentists in both print and digital forms.

This issue features a deep dive in Denver's rich dental history, explores why dentists love the Mile City High, what's next for MDDS, updates from local nonprofits, the dangers of perfectionism, the importance of leaving yourself open to new opportunities and more.

On Blockwise And Reference Panel-Based Estimators For Genetic Data Prediction In High Dimensions, Bingxin Zhao, Shurong Zheng, Hongtu Zhu

Faculty, Staff and Student Publications

Genetic prediction holds immense promise for translating genetic discoveries into medical advances. As the high-dimensional covariance matrix (or the linkage disequilibrium (LD) pattern) of genetic variants often presents a block-diagonal structure, numerous methods account for the dependence among variants in predetermined local LD blocks. Moreover, due to privacy considerations and data protection concerns, genetic variant dependence in each LD block is typically estimated from external reference panels rather than the original training data set. This paper presents a unified analysis of blockwise and reference panel-based estimators in a high-dimensional prediction framework without sparsity restrictions. We find that, surprisingly, even when …

Plagiarism, Richard Alweis, Nagesh Jadhav

Rochester Regional Health authored publications and proceedings

Learning objectives:

• Plagiarism overview
• A special case: large language models (LLM) and academic writing