Medicine and Health Sciences Commons^™

Slip Resistance Evaluation Of 10 Indoor Floor Surfaces, David P. Gilkey, Daniel Autenrieth, Cal Snow, Cody Hays, Sarah Girard, Lorri Birkenbuel

Safety Health & Industrial Hygiene

Slip and fall injuries and fatalities continue to be a signiϐicant problem at work and in the community. Water is the most common contaminant that reduces traction on ϐloors and other walkway surfaces resulting in a slip and fall event. This project investigated 10 common ϐlooring surfaces to assess their slip resistance when dry vs wet and coated vs uncoated. Investigators used the English XL Variable Incidence Tribometer to measure slip resistance under all conditions. Results revealed a signiϐicant (p - value < 0.05) loss of slip resistance when wet vs dry. Investigators also found signiϐicant (p - value < 0.05) increases in traction when using a coating under wet conditions. Researchers support the use of coatings for ϐloors and walkway surfaces that increase traction and reduce the chances of slip and fall events under all conditions.

Emergency Department Staff Compassion Is Associated With Lower Fear Of Enacted Stigma Among Patients With Opioid Use Disorder., Savannah Steinhauser, Rachel Haroz, Iris Jones, William Skelton, Brian M Fuller, Michael B. Roberts, Christopher W Jones, Stephen Trzeciak, Brian W Roberts

PCOM Scholarly Works

OBJECTIVES: Fear of enacted stigma (fear of discrimination or being treated unfairly) is associated with decreased health care-seeking behaviors among patients with opioid use disorder (OUD). We sought to describe the prevalence of fear of enacted stigma among patients presenting to the emergency department (ED) with OUD and to test whether experiencing greater compassion from ED staff is associated with lower fear of enacted stigma.

METHODS: We conducted a cross-sectional study in the ED of an academic medical center between February and August 2023. We included adult patients with OUD presenting to the ED and assessed patient experience of compassion …

Diverse Mentoring Connections Across Institutional Boundaries In The Biomedical Sciences: Innovative Graph Database Analysis, Toufeeq Ahmed Syed, Erika L Thompson, Zainab Latif, Jay Johnson, Damaris Javier, Katie Stinson, Gabrielle Saleh, Jamboor K Vishwanatha

Faculty, Staff and Student Publications

BACKGROUND: With an overarching goal of increasing diversity and inclusion in biomedical sciences, the National Research Mentoring Network (NRMN) developed a web-based national mentoring platform (MyNRMN) that seeks to connect mentors and mentees to support the persistence of underrepresented minorities in the biomedical sciences. As of May 15, 2024, the MyNRMN platform, which provides mentoring, networking, and professional development tools, has facilitated more than 12,100 unique mentoring connections between faculty, students, and researchers in the biomedical domain.

OBJECTIVE: This study aimed to examine the large-scale mentoring connections facilitated by our web-based platform between students (mentees) and faculty (mentors) across institutional …

Decreasing Anxiety During Nursing Skills Evaluation In First-Semester Nursing Students, Terri Davis

Doctor of Nursing Practice Projects

Nursing students experience moderate to severe anxiety related to the rigor of nursing programs. Anxiety often leads to poor performance on exams and skills evaluations. When anxiety is not limited, it can contribute to nursing students being unable to progress in the nursing program and high attrition rates. The National League of Nursing (2021) estimates the attrition rate for nursing students in the United States at 20%. Attrition rates for associate degree programs are even greater and estimated to be around 50% (Kubec, 2017, as cited in Priode et al., 2020). This DNP quality improvement project looks to examine the …

Transition To Success: Development Of A Nursing Faculty Orientation Program, Christine Kaiser

Doctor of Nursing Practice Projects

Nursing faculty transitioning from clinical expert into the novice educator role face the dilemma of learning a new professional role while simultaneously meeting the demands of developing students to become competent nurses. A literature review suggested informal orientation programs lack the guidance necessary to assist novice nursing faculty in the transition to academia. This quality improvement project aims to develop and implement a formal, guided orientation program for nursing faculty with less than three years of experience. The project was implemented using a qualitative pre-post intervention design. Nursing faculty with less than three years of experience completed a Likert scale …

The Effectiveness Of Pressure Injury Prevention Through Educational Intervention Within The Long-Term Care Setting, Ashley Nunley

Doctor of Nursing Practice Projects

The prevalence of pressure injuries, particularly in older adults, continues to be disturbingly high, especially in those suffering from chronic diseases and frailty, bringing a higher awareness of applied preventive and therapeutic measures (Jaul et al., 2019). In long-term care nurses, will an educational, evidenced-based pressure ulcer prevention program impact health outcomes by increasing nurses’ knowledge, compared to no intervention over four weeks? The Pieper-Zulkowski Pressure Ulcer/Injuries Knowledge Test was used to evaluate the nurse's pressure injury knowledge pre- and post-educational intervention. The paired t-test was used to analyze the pre-and post-test data from the educational intervention. This DNP project …

The Flourishing Gut Cookbook, Mackenzie C. Stanley, Brittany Lopez-Itingen

Department of Nutrition Student Projects

Herbs and spices have been used in herbal medicine for thousands of years, and yet these therapeutic approaches used to heal from within are foreign to many Americans. We have decided to create a cookbook utilizing 5 evidence-based gut-healing herbs and spices in hopes to provide tangible recipes to promote gut health. The cookbook will also provide an educational opportunity that will speak to the benefits of each herb or spice in the recipe. Background We have decided to pursue a cookbook as a result of our love of cooking and interest in herbal medicine. We want to learn more …

Development Of A Method For Making Optimal Decisions For Intervention Flexibility During Implementation (Modifi): A Modified Delphi Study, Stephanie K Brewer, Catherine M Corbin, Ana A Baumann, Shannon Wiltsey Stirman, Janine M Jones, Michael D Pullmann, Aaron R Lyon, Modifi Expert Panel

2020-Current year OA Pubs

BACKGROUND: Intervention adaptation is often necessary to improve the fit between evidence-based practices/programs and implementation contexts. Existing frameworks describe intervention adaptation processes but do not provide detailed steps for prospectively designing adaptations, are designed for researchers, and require substantial time and resources to complete. A pragmatic approach to guide implementers through developing and assessing adaptations in local contexts is needed. The goal of this project was to develop Making Optimal Decisions for Intervention Flexibility during Implementation (MODIFI), a method for intervention adaptation that leverages human centered design methods and is tailored to the needs of intervention implementers working in applied …

Structural Characterization Of Ligand Binding And Ph-Specific Enzymatic Activity Of Mouse Acidic Mammalian Chitinase, Roberto Efraín Díaz, Andrew K Ecker, Galen J Correy, Pooja Asthana, Iris D Young, Bryan Faust, Michael C Thompson, Ian B Seiple, Steven Van Dyken, Richard M Locksley, James S Fraser

2020-Current year OA Pubs

Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, Acidic Mammalian Chitinase (AMCase), is an enzyme known for its ability to function under acidic conditions in the stomach but is also active in tissues with more neutral pHs, such as the lung. Here, we used a combination of biochemical, structural, and computational modeling approaches to examine how the mouse homolog (mAMCase) can act in both acidic and neutral environments. We measured kinetic properties of mAMCase activity across …

Cancer-Associated Histone H3 N-Terminal Arginine Mutations Disrupt Prc2 Activity And Impair Differentiation, Benjamin A Nacev, Benjamin A Garcia, Et Al.

2020-Current year OA Pubs

Dysregulated epigenetic states are a hallmark of cancer and often arise from genetic alterations in epigenetic regulators. This includes missense mutations in histones, which, together with associated DNA, form nucleosome core particles. However, the oncogenic mechanisms of most histone mutations are unknown. Here, we demonstrate that cancer-associated histone mutations at arginines in the histone H3 N-terminal tail disrupt repressive chromatin domains, alter gene regulation, and dysregulate differentiation. We find that histone H3R2C and R26C mutants reduce transcriptionally repressive H3K27me3. While H3K27me3 depletion in cells expressing these mutants is exclusively observed on the minor fraction of histone tails harboring the mutations, …

Seeding Activity Of Human Superoxide Dismutase 1 Aggregates In Familial And Sporadic Amyotrophic Lateral Sclerosis Postmortem Neural Tissues By Real-Time Quaking-Induced Conversion, Justin K Mielke, Mikael Klingeborn, Eric P Schultz, Erin L Markham, Emily D Reese, Parvez Alam, Ian R Mackenzie, Cindy V Ly, Byron Caughey, Neil R Cashman, Moses J Leavens

2020-Current year OA Pubs

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with average lifespan of 2-5 years after diagnosis. The identification of novel prognostic and pharmacodynamic biomarkers are needed to facilitate therapeutic development. Metalloprotein human superoxide dismutase 1 (SOD1) is known to accumulate and form aggregates in patient neural tissue with familial ALS linked to mutations in their SOD1 gene. Aggregates of SOD1 have also been detected in other forms of ALS, including the sporadic form and the most common familial form linked to abnormal hexanucleotide repeat expansions in the Chromosome 9 open reading frame 72 (C9ORF72) gene. Here, we report …

Association Of Basal Forebrain Atrophy With Cognitive Decline In Early Alzheimer Disease, Ying Xia, Vincent Dore, Jurgen Fripp, Pierrick Bourgeat, Simon M. Laws, Christopher J. Fowler, Stephanie R. Rainey-Smith, Ralph N. Martins, Christopher Rowe, Colin L. Masters, Elizabeth J. Coulson, Paul Maruff

Research outputs 2022 to 2026

Background and Objectives: In early Alzheimer disease (AD), β-amyloid (Aβ) deposition is associated with volume loss in the basal forebrain (BF) and cognitive decline. However, the extent to which Aβ-related BF atrophy manifests as cognitive decline is not understood. This study sought to characterize the relationship between BF atrophy and the decline in memory and attention in patients with early AD.

Methods: Participants from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study who completed Aβ-PET imaging and repeated MRI and cognitive assessments were included. At baseline, participants were classified based on their clinical dementia stage and Aβ status, yielding groups …

Antidepressant Effect Of Enzymatic Porcine Placenta Hydrolysate In Repeated Immobilization Stress-Induced Ovariectomized Female Mice, Minsook Ye, Sharon Nguyen, Min Ju Kim, Jee Sun Hwang, Gun Won Bae, Keun-Hang Susan Yang, Insop Shim

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

When postmenopausal women are under stress conditions, this exacerbates mood disorders and issues with neuroimmune systems. The porcine placenta is known to relieve menopausal depression in clinical trials, but its underlying mechanisms for depression and anti-inflammatory functions remain poorly defined. The present study was designed to examine the anti-inflammatory effects of enzymatic porcine placenta hydrolysate (EPPH) on LPS-induced levels of nitric oxide (NO), prostaglandin E2 (PGE2), corticosterone (CORT), and pro-inflammatory cytokine interleukin-1 beta (IL-1β) in RAW 264.7 macrophage cells. In addition, the neurite outgrowth of PC12 cells was evaluated to examine the effects of EPPH on neurite growth. To mimic …

Sre-Yolov8: : An Improved Uav Object Detection Model Utilizing Swin Transformer And Re-Fpn, Jun Li, Jiajie Zhang, Yanhua Shao, Feng Liu

Faculty, Staff and Student Publications

To tackle the intricate challenges associated with the low detection accuracy of images taken by unmanned aerial vehicles (UAVs), arising from the diverse sizes and types of objects coupled with limited feature information, we present the SRE-YOLOv8 as an advanced method. Our method enhances the YOLOv8 object detection algorithm by leveraging the Swin Transformer and a lightweight residual feature pyramid network (RE-FPN) structure. Firstly, we introduce an optimized Swin Transformer module into the backbone network to preserve ample global contextual information during feature extraction and to extract a broader spectrum of features using self-attention mechanisms. Subsequently, we integrate a Residual …

Proceedings Of The Cuny Games Conference 10.0, Robert O. Duncan, Grace Axler-Diperte, Joe Bisz, Christina Boyle, Devorah Kletenik, Carolyn Stallard

Publications and Research

The ten-year anniversary (!) of the CUNY Games Conference combines workshops, idea exchanges, interactive participant presentations, playtesting, and playing tabletop games into a two-day hybrid event to promote and discuss game-based learning. The conference focuses on creative pedagogy, such as playful learning activities or games, that teachers can use in the classroom every day. Day 1 featured interactive presentations by attendees, informal idea exchange sessions, and workshops by the conference organizers. Day 2 featured select presentations and workshops, poster sessions, playtesting and game modding, and casual play of tabletop games.

Predictors Of Help Seeking Among Asian Americans With Chronic Pain, Cory Duffield

Clinical Psychology Dissertations

Purpose: Chronic pain can contribute to both physical discomfort and psychological distress. Psychological distress may sometimes increase the odds of seeking help for pain. On the other hand, factors such as attitudes towards receiving help and the need to present oneself as perfect may constitute barriers to seeking help for pain. However, relatively little research has examined such processes in Asian American individuals experiencing chronic pain.

Aim: This study aimed to better understand, in Asian Americans that reported chronic pain, the relationships among distress, help-seeking attitudes, perfectionistic self-presentation (PSP) in predicting help-seeking behaviors. It tested whether higher distress would predict …

Association Of Mildly Elevated Pulmonary Vascular Resistance With Major Cardiovascular Events In Pulmonary Hypertension And Chronic Kidney Disease: A Retrospective Cohort Analysis, Jose M. Martinez Manzano, Alexander Prendergast, Tara John, Raul Leguizamon, Ian Mclaren, Rasha Khan, Andrew Geller, Phuuwadith Wattanachayakul, John Malin, Simone A. Jarrett, Kevin Bryan Lo, Sadia Benzaquen, Christian Witzke

Einstein Health Papers

Pulmonary hypertension (PH) is associated with adverse outcomes in chronic kidney disease (CKD) patients. Our study suggests mildly elevated pulmonary vascular resistance ( > 2 to ≤ 3) is independently associated with major adverse cardiovascular events at 1-year follow-up. Early diagnosis of precapillary PH in CKD patients can potentially improve clinical outcomes.

Measure Do Not Guess: A Call To Action To End Assumed And Estimated Menstrual Cycle Phases In Research, Richard J. Burden, Marco Altini, Eva Ferrer, Tessa R. Flood, Gary Lewin, Sophia Nimphius, Stuart M. Phillips, Kirsty J. Elliott-Sale

Research outputs 2022 to 2026

No abstract provided.

Relationship Between Health Education Systems Incorporated Admission Assessment Scores And Student Completion Of A Baccalaureate Nursing Program, Colleen Peace

Walden Dissertations and Doctoral Studies

Math, reading, and vocabulary comprehension are important skills needed to ensure nursing students have a solid foundation on which to develop critical thinking skills to complete a nursing program. One of the common preadmission standardized tests is the Health Education Systems Incorporated Admission Assessment (HESI A2), but little research had been conducted to determine whether there is a correlation between the score on the HESI A2 and readiness to master nursing courses at the bachelor of science in nursing (BSN) level and completion of the BSN program. The purposes of this quantitative retrospective study, guided by Jeffreys’s nursing undergraduate retention …

Relationship Between Health Education Systems Incorporated Admission Assessment Scores And Student Completion Of A Baccalaureate Nursing Program, Colleen Peace

Walden Dissertations and Doctoral Studies

Math, reading, and vocabulary comprehension are important skills needed to ensure nursing students have a solid foundation on which to develop critical thinking skills to complete a nursing program. One of the common preadmission standardized tests is the Health Education Systems Incorporated Admission Assessment (HESI A2), but little research had been conducted to determine whether there is a correlation between the score on the HESI A2 and readiness to master nursing courses at the bachelor of science in nursing (BSN) level and completion of the BSN program. The purposes of this quantitative retrospective study, guided by Jeffreys’s nursing undergraduate retention …

Sting Agonist 8803 Reprograms The Immune Microenvironment And Increases Survival In Preclinical Models Of Glioblastoma, Hinda Najem, Spencer T Lea, Shashwat Tripathi, Lisa Hurley, Chao-Hsien Chen, Ivana William, Moloud Sooreshjani, Michelle Bowie, Genevieve Hartley, Corey Dussold, Sebastian Pacheco, Crismita Dmello, Catalina Lee-Chang, Kathleen Mccortney, Alicia Steffens, Jordain Walshon, Martina Ott, Jun Wei, Anantha Marisetty, Irina Balyasnikova, Roger Stupp, Rimas V Lukas, Jian Hu, Charles David James, Craig M Horbinski, Maciej S Lesniak, David M Ashley, Waldemar Priebe, Leonidas C Platanias, Michael A Curran, Amy B Heimberger

Faculty, Staff and Student Publications

STING agonists can reprogram the tumor microenvironment to induce immunological clearance within the central nervous system. Using multiplexed sequential immunofluorescence (SeqIF) and the Ivy Glioblastoma Atlas, STING expression was found in myeloid populations and in the perivascular space. The STING agonist 8803 increased median survival in multiple preclinical models of glioblastoma, including QPP8, an immune checkpoint blockade-resistant model, where 100% of mice were cured. Ex vivo flow cytometry profiling during the therapeutic window demonstrated increases in myeloid tumor trafficking and activation, alongside enhancement of CD8+ T cell and NK effector responses. Treatment with 8803 reprogrammed microglia to express costimulatory CD80/CD86 …

Increasing Nurses’ Knowledge Of Cultural Preferences Influencing Diabetes Self-Management Among Sierra Leoneans, Winstina Aminata Taylor

Walden Dissertations and Doctoral Studies

The practice problem identified at the project site was the lack of nurses’ knowledge of how cultural preferences influence diabetes self-management practices among African Americans with diabetes mellitus. An educational program focused on the cultural preferences of Sierra Leoneans that influence diabetes self-management practices was provided for 48 nurses who worked in the agency. The doctoral project included concepts from nursing education and cultural competence theories to inform the approach. The project followed the ADDIE model process steps to develop and implement the educational program. The sources of evidence included pre- and posteducation surveys administered to participating nurses to assess …

Increasing Nurses’ Knowledge Of Cultural Preferences Influencing Diabetes Self-Management Among Sierra Leoneans, Winstina Aminata Taylor

Walden Dissertations and Doctoral Studies

The practice problem identified at the project site was the lack of nurses’ knowledge of how cultural preferences influence diabetes self-management practices among African Americans with diabetes mellitus. An educational program focused on the cultural preferences of Sierra Leoneans that influence diabetes self-management practices was provided for 48 nurses who worked in the agency. The doctoral project included concepts from nursing education and cultural competence theories to inform the approach. The project followed the ADDIE model process steps to develop and implement the educational program. The sources of evidence included pre- and posteducation surveys administered to participating nurses to assess …

The Ifitm5 Mutation In Osteogenesis Imperfecta Type V Is Associated With An Erk/Sox9-Dependent Osteoprogenitor Differentiation Defect, Ronit Marom, I-Wen Song, Emily C Busse, Megan E Washington, Ava S Berrier, Vittoria C Rossi, Laura Ortinau, Youngjae Jeong, Ming-Ming Jiang, Brian C Dawson, Mary Adeyeye, Carolina Leynes, Caressa D Lietman, Bridget M Stroup, Dominyka Batkovskyte, Mahim Jain, Yuqing Chen, Racel Cela, Alexis Castellon, Alyssa A Tran, Isabel Lorenzo, D Nicole Meyers, Shixia Huang, Alicia Turner, Vinitha Shenava, Maegen Wallace, Eric Orwoll, Dongsu Park, Catherine G Ambrose, Sandesh Cs Nagamani, Jason D Heaney, Brendan H Lee

Faculty, Staff and Students Publications

Osteogenesis imperfecta (OI) type V is the second most common form of OI, distinguished by hyperplastic callus formation and calcification of the interosseous membranes, in addition to the bone fragility. It is caused by a recurrent, dominant pathogenic variant (c.-14C>T) in interferon-induced transmembrane protein 5 (IFITM5). Here, we generated a conditional Rosa26-knockin mouse model to study the mechanistic consequences of the recurrent mutation. Expression of the mutant Ifitm5 in osteo-chondroprogenitor or chondrogenic cells resulted in low bone mass and growth retardation. Mutant limbs showed impaired endochondral ossification, cartilage overgrowth, and abnormal growth plate architecture. The cartilage phenotype correlates with …

Efficacy And Safety Of Esmethadone (Rel-1017) In Patients With Major Depressive Disorder And Inadequate Response To Standard Antidepressants: A Phase 3 Randomized Controlled Trial, Maurizio Fava, Stephen M Stahl, Luca Pani, Sara De Martin, Andrew J Cutler, Vladimir Maletic, Charles W Gorodetzky, Frank J Vocci, Frank L Sapienza, Thomas R Kosten, Cornelia Kröger, Paggard Champasa, Cedric O'Gorman, Clotilde Guidetti, Andrea Alimonti, Stefano Comai, Andrea Mattarei, Franco Folli, David Bushnell, Sergio Traversa, Charles E Inturrisi, Paolo L Manfredi, Marco Pappagallo

Faculty, Staff and Students Publications

No abstract provided.

Maldi Imaging Mass Spectrometry Visualizes The Distribution Of Antidepressant Duloxetine And Its Major Metabolites In Mouse Brain, Liver, Kidney, And Spleen Tissues, Saleh M Khalil, Xuan Qin, John M Hakenjos, Jian Wang, Zhaoyong Hu, Xinli Liu, Jin Wang, Mirjana Maletic-Savatic, Kevin R Mackenzie, Martin M Matzuk, Feng Li

Faculty, Staff and Student Publications

Imaging mass spectrometry (IMS) is a powerful tool for mapping the spatial distribution of unlabeled drugs and metabolites that may find application in assessing drug delivery, explaining drug efficacy, and identifying potential toxicity. This study focuses on determining the spatial distribution of the antidepressant duloxetine, which is widely prescribed despite common adverse effects (liver injury, constant headaches) whose mechanisms are not fully understood. We used high-resolution IMS with matrix-assisted laser desorption/ionization to examine the distribution of duloxetine and its major metabolites in four mouse organs where it may contribute to efficacy or toxicity: brain, liver, kidney, and spleen. In none …

Incidence Of Orbital Mucocele Following Orbital Floor Fracture Repair, Adeem M. Nachabe, Genevieve E. Messa, Jonathan C. Boraski

School of Medicine Faculty Publications

Mucoceles can often present as a complication after prior sinus surgery or maxillofacial trauma when mucosal drainage is obstructed. Their presence in the orbit following orbital wall fracture and subsequent repair represent an exceedingly rare complication whose occurrence is limited to a few reported cases in the literature. In these patients, continuous cyst expansion and subsequent mass effect may lead to ophthalmic symptoms, including orbital pain, proptosis, diplopia, and globe dystopia. We report the discovery of an orbital mucocele after orbital floor fracture repair and its possible association with the nonporous reconstruction plate utilized for fixation. When a patient with …

Roadside Head Trauma In A Middle-Aged Man, Ian Michael Crimmins, David Isaac Beran

School of Medicine Faculty Publications

No abstract provided.

Flattening Morrison's Beloved: The Limits Of Psychoanalysis In Literary Criticism, A Literature Review, Isaac Vanhook

University Honors Theses

Toni Morrison's Beloved was first published in 1987 and has amassed a wide range of scholarship throughout the years; with some literary scholars using psychoanalysis to suggest a reading of Beloved. Because of the volume of scholarship and Beloved's plot--dealing with a mother who represses the memory of killing her daughter, Beloved--I found it to be perfect for the scope of this project. This literature review focuses on the sometimes reductive qualities of psychoanalyzing Beloved (such as the Freudian universal psychoanalytic subject, and the 'drawbacks' of object relations theory), while also discussing some revelatory qualities via the same …

The Health Risks Of Deportation: Impacts Of Family Separation On Relationships And Wellbeing In Latinx Communities, Shantay Rhea Rocha

University Honors Theses

Anti-immigration policy and deportation practices create multifaceted implications for Latinx communities in the United States. A comprehensive literature review drawing from public health and immigration studies was used to examine the direct and indirect implications of separation of families due to deportation. This thesis synthesizes existing research to illuminate the health threats pertaining to Latinx wellbeing in the context of being undocumented and fearing being separated from their family. Addressing the dimensions of deportation-related health risks, policy makers, health care professionals, and community organizations can work towards promoting Latinx health and well-being in the U.S. to mitigate the health consequences …