Medicine and Health Sciences Commons^™

Changes In Lean Body Mass With Glucagon-Like Peptide-1-Based Therapies And Mitigation Strategies, Ian J. Neeland

Faculty Scholarship

Weight loss induced by glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual glucagon-like peptide-1 receptor (GLP-1R)/glucose-dependent insulinotropic polypeptide receptor agonists is coming closer to the magnitudes achieved with surgery. However, with greater weight loss there is concern about potential side effects on muscle quantity (mass), health and function. There is heterogeneity in the reported effects of GLP-1-based therapies on lean mass changes in clinical trials: in some studies, reductions in lean mass range between 40% and 60% as a proportion of total weight lost, while other studies show lean mass reductions of approximately 15% or less of total weight lost. There …

Reporting Clinical Cases: Advancing Homoeopathy, One Case At A Time, Subhash Kaushik

Indian Journal of Research in Homoeopathy

Case reports have been invariably contributing to the research world in their own way. They remain a popular genre among the readers, especially the clinicians who lay their hands upon a clinical journal with an interest to pick new knowledge about a certain disease or a drug than to learn about new evidence generated through statistical calculations. Its presence in medical literature is reported to be quite ancient, with some evidence dated back to the Egyptian antiquity. In fact, a well-documented case report is a representative version of many similar clinical success stories.

Management Of Psychosis With Individualised Homoeopathic Medicines: A Case Series, Karunakara Moorthi, Susu Pertin, Mohan Narvelil Devasia

Indian Journal of Research in Homoeopathy

Background: Psychosis is a clinical syndrome. The main clinical signs of psychosis are delusion and hallucination. It is a crucial focus of diagnosis and treatment in neurologic and psychiatric practice since it functionally disturbs numerous psychiatric, neurodevelopmental, neurologic and medical diseases.

Case summary: The World Health Organization Quality of Life Scale and the Brief Psychiatric Rating Scale were used to evaluate the patients. The outcomes in all the cases suggested that homoeopathic treatment can play a significant role in easing psychotic symptoms and restoring the patient’s ability to understand. The most frequently prescribed medicines and potencies in these cases were …

Homoeopathic Treatment Of Oral Leucoplakia: A Case Report, Suraia Parveen, Zeeshan Ahmed

Indian Journal of Research in Homoeopathy

Introduction: Oral leucoplakia (OL), a premalignant lesion which is more frequently encountered in elderly people, is defined as a white lesion of the oral mucosa. Smoking is one of the most common risk factors. Conventionally, surgical excision is the most recommended treatment option for OL. Case Summary: A 55-year-old male presented with the complaint of a whitish lesion inside the left angle of the mouth (buccal mucosa) for the past 1½ years. The case was clinically diagnosed as OL. He was advised for surgical excision, but he preferred to go for homoeopathic treatment. Based on characteristic symptoms, repertorial analysis and …

Resolution Of Subdural Hygroma With Homoeopathy: A Case Report, Partha Pratim Pal, Tania Chatterjee

Indian Journal of Research in Homoeopathy

Introduction: Subdural hygroma (SDH) is a collection of cerebrospinal fluid in the subdural space which may be idiopathic, traumatic or post-surgical occurring mostly in elderly patients. Case Summary: A 42-year-old female reported an acute complaint of compressing headache. The headache persisted even after initial prescriptions of Ruta graveolens 30C and 200C, which did not alleviate the condition. Further evaluation was done with a computed tomography scan, which revealed left-sided SDH. Tuberculinum 1M was prescribed, but even though the pain subsided, profuse, watery discharge began to ooze from both the ears and nose, which eventually stopped spontaneously. After six months, the …

Management Of Post-Operative Breast Nodules With Homoeopathy: A Case Report, Nisanth K.M. Nambison, Smita N. Nambison, Abhishek D. Dwivedi, Nisha Chakravarty

Indian Journal of Research in Homoeopathy

Introduction: Palpable masses after mastectomy are commonly detected by patients or their physicians. Imaging of palpable masses is advised following a complete history and physical examination. This is a case of breast nodules occurring after the removal of cancerous tissue in the breast. Homoeopathy, with its holistic approach, can treat the disease by addressing its multifactorial origin.

Case summary: A 71-year-old female, diagnosed with post-operative breast nodules after surgical excision of mucinous carcinoma portion of the left breast, was treated with individualised homoeopathic treatment for six months with subsequent improvement. This case provides preliminary evidence for the potential usefulness of …

Homoeopathic Medicine Arsenic Album 200c In Treatment Of Plaque Psoriasis: A Case Report, Neha Nagar, Ravi K. Poswal, Ajay Kumar, Kanak Singhal

Indian Journal of Research in Homoeopathy

Introduction: Psoriasis is a non-communicable, chronic, mostly painful, disfiguring disease. It can have a negative impact on patients’ quality of life, which may occur at any age. The conventional treatment includes local and systemic therapies, as well as phototherapy. The need for treatment is usually lifelong as remission occurs quite frequently. Case Summary: We present here a case report of a 32-year-old woman with psoriatic lesions all over the body for 15 years with intolerable itching. The present case was completely cured after 1 year 6 months of regular treatment with individualised homoeopathic medicine without any adverse effects. After detailed …

Plantar Warts Treated With Homoeopathic Medicine Antimonium Crudum: A Case Report, Laijun Nahar, Ruma Debbarma

Indian Journal of Research in Homoeopathy

Introduction: Plantar warts are cutaneous lesions brought on by human papilloma virus infection. There is a range of alternative treatment available for it, including cryotherapy, chemical cauterisation, curettage, electrodessication and laser removal. However, a majority of these treatments can leave scars or may provide only temporary relief. Case Summary: A 19-year-old female presented with multiple, right-sided plantar warts and was successfully treated by a single, individualised homoeopathic medicine, Antimonium crudum 200C for two months. The improvement was assessed through photographs taken in subsequent follow-up visits. The case was monitored further for a period of six months without any recurrence. This …

Individualised Homoeopathic Treatment For Pilonidal Sinus: A Case Report, Sumit Paliwal, Laijun Nahar, Rachna Paliwal

Indian Journal of Research in Homoeopathy

Introduction: Pilonidal sinus is a very common inflammatory disease of the gluteal region. The most common site of occurrence is the natal cleft. It can cause discomfort, absence from work and social embarrassment. There is no single, widely accepted therapy available for this condition. In most cases, the treatment option for this disease is surgical intervention, but recurrences following surgery are common. Case Summary: A 15-year-old male patient reported discharge from the sinus cavity in the natal cleft along with pain and discomfort. Nitric acid, a homoeopathic medicine, was prescribed during the initial consultation and the patient was followed …

Diabetic Foot Ulcer Treated With The Homoeopathic Medicine Lachesis Mutus In Millesimal Potencies: A Case Report, Lalith Singh, Raja Manoharan, Niharika Shaw, Saleem Ansari

Indian Journal of Research in Homoeopathy

Introduction: Diabetic foot ulcer (DFU) is the most common neuropathic complication of diabetes. Uncontrolled diabetes and improper foot care lead to serious conditions like DFU from minor injuries. Regular dressing and proper foot care are required for its improvement. Patients are left with no other option than amputation of the limb. Dressing for a longer period seems not convenient and feasible at the patient’s end. DFU also has wet gangrene as one of its major complications. Case Summary: This case report presents a case of a diabetic patient complaining of a foot ulcer for the past nine years, following the …

Research Highlights, Shatakshi Bhardwaj, Archna Nagar

Indian Journal of Research in Homoeopathy

Research Highlights

Roles Of Mitochondrial Chchd2 And Gpcr-Associated Β-Arrestin2 In The Pathogenesis Of Lewy Body Disorders, Teresa R. Kee

USF Tampa Graduate Theses and Dissertations

Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) is a mitochondrial protein that plays important roles in cristae structure, oxidative phosphorylation, and apoptosis. Multiple mutations in CHCHD2 have been associated with Lewy body disorders (LBDs), such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), with the CHCHD2T61I mutation being the most widely studied. We generated the first transgenic mouse models expressing human CHCHD2WT and the PD-linked CHCHD2T61I mutation driven by the mPrP promoter. CHCHD2T61I Tg, but not CHCHD2WT Tg mice exhibit perinuclear mitochondrial aggregates, neuroinflammation, and have impaired long-term synaptic plasticity associated with synaptic dysfunction. Dopaminergic neurodegeneration, a hallmark of PD, …

Infantile Haemangioma Treated With Homoeopathy: A Case Report, Harpreet Kaur, Ravinder Singh

Indian Journal of Research in Homoeopathy

Introduction: Infantile haemangiomas (IH) are common benign tumours of infancy. Approximately, one in ten infants gets affected. The male-tofemale ratio is variable, with some reports suggesting that females are more prone than males. In India, the prevalence of IH in various studies has been reported as varying from 0.1% to 0.28%. The head and neck are the regions where most of the haemangiomas are located. The lesions are apparent soon after birth and are followed by rapid proliferation during the first year of life and a gradual involution occurs over the next five to ten years. Case summary: …

Management Of Tinea Corporis With The Minimum Doses Of Homoeopathic Nosode Psorinum: A Case Report, Punam Kumari, Shivam Kumar, Renu Verma

Indian Journal of Research in Homoeopathy

Introduction: Tinea corporis (TC) is the most common superficial fungal infection of the skin that invades and grows in dead keratin. The topical treatment causes suppression of TC and with the effect of it, a repeated episode of relapse occurs, which hampers the quality of life of the patient. Case Summary: This case of TC, with extensive spread on the body, demonstrates the curative effect of homoeopathic medicine with minimum dosage. A 64-year-old male diagnosed with TC was treated successfully with individualised homoeopathic medicine for seven months. The outcome was assessed through before-and-after-treatment photographs. Dermatology Life Quality Index (DLQI) score …

A Case Report Of Attention Deficit Hyperactivity Disorder In Preschool Children Treated With Individualised, Constitutional Homoeopathic Medicine, Karunakara Moorthi, Lalitha K S

Indian Journal of Research in Homoeopathy

Introduction: Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric disorder affecting children of all ages, including preschoolers, adolescents, and adults worldwide. ADHD patients often face challenges in academic and social settings. Notably, pre-school children are more likely to exhibit hyperactive-impulsive symptoms than school-age children. Research on treating pre-schoolers with ADHD is limited compared to older children. This case report demonstrates the treatment of ADHD in pre-schoolers using individualised homoeopathic remedies. Case Summary: A 4-year-old boy presented with a 2-year history of symptoms, such as restlessness, easy distractibility and aggressive behaviour. After assessing the case, the institute’s psychiatric consultant diagnosed it …

Laryngopharyngeal Reflux Disease With Vocal Cord Oedema Treated With Individualised Homoeopathic Medicine: A Case Report, Partha Pratim Pal, Laijun Nahar

Indian Journal of Research in Homoeopathy

Introduction: The diagnosis of laryngopharyngeal reflux disease (LPRD) is still ambiguous due to limited and cumbersome diagnostic standards. To achieve regression of both symptoms and laryngeal findings due to LPRD, it typically requires more vigorous and sustained treatment. In certain patients with chronic acid or non-acid reflux, surgery may be helpful. Case Summary: This is the case of a 68-year-old man who was diagnosed with LPRD and had vocal cord oedema. Individualised homoeopathic medicine, Natrum sulphuricum, was prescribed, and the patient improved steadily in terms of signs and symptoms and had no further complaints at the end of 16 …

Cutaneous Warts Treated With A Single Dose Of The Homoeopathic Medicine Carcinosin 200c: An Evidence-Based Case Report, Sivakumar K, Mamatha Mohan

Indian Journal of Research in Homoeopathy

Introduction: Cutaneous warts are hyperkeratotic protrusions over the skin caused by human papilloma virus (HPV). These are common throughout the world. Cutaneous warts can occur at any age but are unusual in early childhood and infancy. Warts are often diagnosed clinically on physical examination, but some dysplastic lesions may require laboratory confirmation of HPV. Spontaneous clearance is not always possible, and offering a reliable prognosis to the individual case is impossible. Even though warts are frequently encountered in the day-to-day practice of homoeopathy, and the results are promising, there are limited research studies available in the online database. Case Summary: …

The Influence Of Childhood Trauma On Dna Methylation Patterns And Sex-Specific Cortisol Stress Reactivity: A Secondary Analysis, Isabella F. Correia

USF Tampa Graduate Theses and Dissertations

Childhood trauma has been shown to significantly impact physical and mental health outcomes, leading to conditions such as heart disease, diabetes, depression, and difficulties in decision-making and maintaining relationships. Exposure to such trauma has the potential to dysregulate an individual’s stress response system, resulting in abnormal cortisol levels. Many studies suggest a lasting impact of early-life stress on DNA methylation patterns and, separately, cortisol stress reactivity. In addition, there are known sex differences in exposure to childhood trauma and cortisol reactivity; yet studies to date have not investigated whether there is an association to DNA methylation. This study utilized a …

Cgmp Compliant One-Step, One-Pot Automated [18f]Fbntp Production For Clinical Imaging Of Mitochondrial Activity, Mai Lin, Cong-Dat Pham, Robert T Ta, H Charles Manning

Faculty, Staff and Student Publications

Background

4-[18F]fluorobenzyl-triphenylphosphonium ([18F]FBnTP) is a lipophilic cation PET tracer. The cellular uptake of [18F]FBnTP is correlated with oxidative phosphorylation by mitochondria, which has been associated with multiple critical diseases. To date, [18F]FBnTP has been successfully applied for imaging myocardial perfusion, assessment of severity of coronary artery stenosis, delineation of the ischemic area after transient coronary occlusion, and detection/quantification of apoptosis in various animal models. Recent preclinical and clinical studies have also expanded the possibilities of using [18F]FBnTP in oncological diagnosis and therapeutic monitoring. However, [18F]FBnTP is typically prepared through a tediously lengthy four-step, three-pot reaction and required multiple synthesizer modules; …

The Significant Associations Between Epigenetic Clocks And Bladder Cancer Risks, Yang Deng, Chia-Wen Tsai, Wen-Shin Chang, Yifan Xu, Maosheng Huang, Da-Tian Bau, Jian Gu

Faculty, Staff and Student Publications

Bladder cancer is an age-related disease, with over three-quarters of cases occurring in individuals aged 65 years and older. Accelerated biological aging has been linked to elevated cancer risks. Epigenetic clocks serve as excellent predictors of biological age, yet it remains unclear whether they are associated with bladder cancer risk. In this large case-control study, we assessed the associations between four well-established epigenetic clocks-HannumAge, HorvathAge, GrimAge, and PhenoAge-and bladder cancer risk. Utilizing single nucleotide polymorphisms (SNPs), which were identified in a genome-wide association study (GWAS), linked to these clocks as instruments, we constructed a weighted genetic risk score (GRS) for …

Developing A Fit-For-Purpose Composite Symptom Score As A Symptom Burden Endpoint For Clinical Trials In Patients With Malignant Pleural Mesothelioma, Charles S Cleeland, Karen N Keating, Brian Cuffel, Cem Elbi, Jonathan M Siegel, Christoph Gerlinger, Tara Symonds, Jeff A Sloan, Amylou C Dueck, Andrew Bottomley, Xin Shelley Wang, Loretta A Williams, Tito R Mendoza

Faculty, Staff and Student Publications

We developed a composite symptom score (CSS) representing disease-related symptom burden over time in patients with malignant pleural mesothelioma (MPM). Longitudinal data were collected from an open-label Phase IIB study in which 239 patients completed the validated MD Anderson Symptom Inventory for MPM (MDASI-MPM). A blinded, independent review committee of external patient-reported outcomes experts advised on MDASI-MPM symptoms to include in the CSS. Through iterative analyses of potential symptom-item combinations, 5 MPM symptoms (pain, fatigue, shortness of breath, muscle weakness, coughing) were selected. The CSS correlated strongly with the full MDASI-MPM symptom set (0.92-0.94) and the Lung Cancer Symptom Scale-Mesothelioma …

The Role Of Spontaneous Activity In Maturation Of The Calyx Of Held Nerve Terminal And Its Synaptic Target In The Medial Nucleus Of The Trapezoid Body, Daniel Tatsuo Heller

USF Tampa Graduate Theses and Dissertations

Neural circuit formation is a complex process involving synergistic roles between neurons and glial cells regulated by coordinated genetic and molecular cues and activity-dependent mechanisms. The canonical pathway for synapse formation begins with neurogenesis and migration followed by axonal outgrowth and dendritic arborization allowing for the capture and formation of nascent synapses. These initial synaptic contacts are exuberant in nature ensuring proper neural connectivity and undergo a period of pruning of superfluous inputs followed by maturation and strengthening of the remaining contacts. This maturation includes pre- and postsynaptic specialization of the active zone, localization and clustering of ion channels, and …

The Frailty Trajectory's Additional Edge Over The Frailty Index: Retrospective Cohort Study Of Veterans With Heart Failure, Javad Razjouyan, Ariela R Orkaby, Molly J Horstman, Parag Goyal, Orna Intrator, Aanand D Naik

Faculty, Staff and Students Publications

No abstract provided.

Benefits Of Acceptance And Commitment Therapy (Act) For Chronic Pain, Maria Kleinstaeuber, Ashley Yaugher, Emily Roundy, Michael Levin

All Current Publications

Chronic pain is a common experience for people and can be difficult to manage. However, there are many evidence-based and effective psychological treatments for chronic pain to help people improve their lives. One of these is acceptance and commitment therapy, or ACT. ACT teaches how to accept pain and live a life full of meaning and quality, with pain. It helps individuals increase their quality of life through mindfulness-based methods, experiential processing, and a focus on values, goals, and actions. ACT has been shown to be effective in reducing pain and improving pain management and personal well-being. Consult the resources …

A Systematic Review Of Telehealth Utilization For Bowel Management Programs In Pediatric Colorectal Surgery., Elizaveta Bokova, Ismael Elhalaby, Seth Saylors, Irene Isabel P. Lim, Rebecca M. Rentea

Manuscripts, Articles, Book Chapters and Other Papers

Recent advancements in pediatric surgery have embraced telehealth (TH) modalities, transitioning from traditional in-person consultations to virtual care. This shift has broadened access to healthcare, potentially enhancing affordability, patient and caregiver satisfaction, and clinical outcomes. In pediatric colorectal surgery, telehealth has been effectively utilized to support Bowel Management Programs (BMPs) for children suffering from constipation and fecal incontinence. A systematic review was conducted to assess the effectiveness of virtual BMPs, analyzing studies from January 2010 to December 2023, sourced from MEDLINE (via PubMed), Embase, and the Cochrane Library, with five studies included. Remote BMPs, implemented through video or telephone consultations, …

Beyond The Airway, Volume 1, Issue 1, May 2024

Beyond the Airway

Table of Contents

3 - Foreword from the Editors-In-Chief

4 - A message from Dr. Eric S. Schwenk

5 - An Interview with Dr. Rishi Kothari

7 - Anesthesia Considerations for Patients on Semaglutide

9 - An Interview with Dr. Jeffrey Mojica

11 - The National Resident Matching Program (NRMP) Match: Is Anesthesiology Becoming More Competitive?

13 - An Interview with Dr. Katherine Dillon and Dr. Matteo Petrera

15 - History of Ketamine in Anesthesia

17 - Editorial Staff

Deciphering Dyspnea: Exercise-Related Flail Mitral Valve Masquerading As Pneumonia, Mehtab Galeh, Amjad Nader, Rania Esteitie

Journal of Shock and Hemodynamics

A 62-year-old male presented with a sudden onset of dyspnea following a racquetball session. Vital signs revealed a blood pressure of 136/63 mm Hg, heart rate of 116 beats/min, respiratory rate of 26 breaths/min, temperature of 98.7º F, and oxygen saturation of 85% on room air. The physical examination was notable for tachycardia, no audible murmur, and bilateral coarse breath sounds on lung auscultation. Pertinent laboratory data showed leukocytosis, elevated lactic acidosis, and elevated brain natriuretic peptide. Arterial blood gas analysis on room air revealed a pH of 7.39, partial pressure of carbon dioxide of 32 mm Hg, and arterial …

Sport Health Care Providers Knowledge Of Pain-Relieving Medications Including Opioids, Jackie Vandertuin, Dalya Abdulla, Stephanie Lowther, Miranda Manolakos

Internet Journal of Allied Health Sciences and Practice

Background: Sport health care providers (SHCP) frequently field inquiries from athletes and key stakeholders regarding pain-relieving procedures, including medications. Purpose: This study sought to investigate the knowledge and role of SHCPs in managing and dispensing pain-relieving medications (PRMs), including opioids, for Canadian athletes. Method: Certified athletic therapists, registered sport massage therapists, licensed doctor of chiropractic sport sciences, and registered physiotherapists were sent an online survey. Percentage responses for each question as well Chi-squared analyses to determine potential interactions between questions were calculated. Results: Findings revealed a significant majority of participants (80%) self-reported having a “great deal” or “some” knowledge about …

Director Of Clinical Education Training In Doctor Of Physical Therapy Programs, Michele (Shelly) Lewis, Eric Folkins

Internet Journal of Allied Health Sciences and Practice

Purpose: Directors of clinical education (DCEs) need knowledge and skills in many areas to succeed in their roles.Not only does the DCE need to master the traditional faculty roles of scholarship, service, and teaching, but the DCE also needs to become competent in administrative duties. Lack of training, especially in research, can negatively affect the DCEs’ ability to perform their responsibilities effectively and efficiently. In this study, we aimed to examine how DCEs learn their numerous roles and how training and experience influence self-perceived competence. Method: In this quantitative, non-experimental study, we used an online survey to obtain information from …

Perspectives Of Medical And Dental Undergraduate Students On Educational Strategies During And Post Covid-19 Lockdown, Syed Junaid Hasan, Syed Yawar Ali Abidi, Samira Adnan, Muhammad Elham Habib, Maham Muneeb Lone, Isma Sajjad, Jamshed Ahmed

Internet Journal of Allied Health Sciences and Practice

Introduction After the emergence and declaration of Covid-19 as a pandemic in March 2019, many countries implemented lockdown with cessation of essential and non-essential activities including educational and academic processes, in order to restrict the spread of the disease,. This necessitated the shift of education from face -to-face conventional methods towards online teaching and assessment practices in all domains, including medicine. This study determined the perspectives and level of satisfaction of medical and dental undergraduate students regarding the online teaching and assessment modes practiced during and after Covid-19 lockdown period. Method: The study was conducted at various medical and dental …