Medicine and Health Sciences Commons^™

A Comprehensive Scoping Review Of Snoezelen Room In Occupational Therapy Best Practices, Muhammad Hidayat Sahid, Andriani Pratiwi, Mohamad Ghazali Masuri, Akehsan Dahlan

Jurnal Epidemiologi Kesehatan Indonesia

Penelitian ini merupakan analisis komprehensif terhadap literatur, penelitian, dan sumber daya yang terkait dengan ruang Snoezelen, dengan tujuan menyajikan gambaran mengenai manfaat, praktik terbaik, dan potensi aplikasi dari lingkungan multi-sensorik ini. Tinjauan ini mensintesis dan menganalisis secara kritis informasi yang tersedia untuk berkontribusi pada pemahaman dan implementasi ruang Snoezelen bagi individu dengan kebutuhan beragam. Pencarian sistematis basis data elektronik, termasuk PubMed, PsycINFO, dan CINAHL, bersama dengan pencarian manual pada daftar referensi, mengidentifikasi 27 artikel relevan yang memenuhi kriteria inklusi. Proses seleksi yang ketat memastikan inklusi sumber yang berkualitas tinggi dan relevan. Metode ekstraksi dan sintesis data digunakan untuk mengidentifikasi tema …

Hubungan Campak Dengan Berat Badan Kurang Pada Anak Usia 24-59 Bulan Di Indonesia (Analisis Data Survei Status Gizi Indonesia 2021), Wiandhari Esa Gautami, Mondastri Korib Sudaryo

Jurnal Epidemiologi Kesehatan Indonesia

Berat badan kurang atau underweight merupakan masalah gizi kurang yang diukur dengan perbandingan berat badan dan umur. Berat badan kurang pada balita akan mempengaruhi pertumbuhan fisik, kemampuan kognitif, meningkatkan risiko kematian dan penularan infeksi penyakit, salah satu penyakit infeksi yang umum terjadi pada balita adalah campak. Tujuan penelitian ini adalah mengetahui hubungan infeksi campak dengan berat badan kurang pada balita usia 24-59 bulan di Indonesia, dengan mengontrol variabel kovariat diantaranya jenis kelamin, usia, pendidikan ibu BBLR, riwayat TB paru, riwayat diare, riwayat ISPA, riwayat imunisasi campak dan pola makan. Studi ini menggunakan data Survei Status Gizi Indonesia (SSGI) di 34 …

Pengaruh Komplikasi Kehamilan Terhadap Kematian Neonatal Dini Di Indonesia: Analisis Data Survei Demografi Dan Kesehatan Indonesia (Sdki) 2017, Fatimah Fatimah, Asri Adisasmita Prof

Jurnal Epidemiologi Kesehatan Indonesia

Kematian neonatal dini merupakan penyumbang 2/3 dari kematian neonatal yang merupakan indikator derajat kesejahteraan dan kesehatan bangsa. Tingkat kematian bayi di Indonesia masih cukup tinggi jika dibandingkan dengan negaranegara Asia lainnya. Komplikasi selama kehamilan diduga sebagai salah satu faktor utama penyebab kematian neonatal dini. Tujuan dari penelitian ini adalah untuk menentukan sejauh mana hubungan antara komplikasi kehamilan dan kematian neonatal dini di Indonesia. Penelitian ini mengadopsi pendekatan crosssectional menggunakan set data yang digunakan berasal dari Survei Demografi Kesehatan Indonesia 2017. Variabel dependen pada studi ini adalah kematian neonatal dini dari anak terakhir yang dilahirkan responden yang berusia 15 – 49 …

Hubungan Komorbiditas Terhadap Kondisi Akhir Pasien Covid-19 Di Rsud Siti Fatimah Provinsi Sumatera Selatan, Dewie Suranti

Jurnal Epidemiologi Kesehatan Indonesia

Pada tahun 2021, Indonesia menempati peringkat pertama dengan kasus COVID-19 terbanyak di ASEAN. Angka kematian COVID-19 di Indonesia sebesar 3,4% dan peringkat ke-5 ditempati oleh Provinsi Sumatera Selatan. Penelitian terdahulu menunjukkan komorbiditas berkontribusi terhadap kematian pasien COVID-19 disertai usia dan jenis kelamin. Penelitian ini bertujuan untuk menganalisis peran usia, jenis kelamin, dan komorbiditas terhadap kondisi akhir pasien COVID-19 di RSUD Siti Fatimah. Metode penelitian menggunakan desain cohort retrospective dengan analisis cox regression pendekatan model proportional hazard. Penelitian ini menggunakan data sekunder yaitu rekam medik pasien terkonfirmasi COVID-19 di RSUD Siti Fatimah dari Januari-Desember 2021 berjumlah 928 pasien yang diambil dengan …

A Non-Invasive Ai-Based System For Precise Grading Of Anosmia In Covid-19 Using Neuroimaging, Hossam Magdy Balaha, Mayada Elgendy, Ahmed Alksas, Mohamed Shehata, Norah Saleh Alghamdi, Fatma Taher, Mohammed Ghazal, Mahitab Ghoneim, Eslam Hamed Abdou, Fatma Sherif, Ahmed Elgarayhi, Mohammed Sallah, Mohamed Abdelbadie Salem, Elsharawy Kamal, Harpal Sandhu, Ayman El-Baz

All Works

COVID-19 (Coronavirus), an acute respiratory disorder, is caused by SARS-CoV-2 (coronavirus severe acute respiratory syndrome). The high prevalence of COVID-19 infection has drawn attention to a frequent illness symptom: olfactory and gustatory dysfunction. The primary purpose of this manuscript is to create a Computer-Assisted Diagnostic (CAD) system to determine whether a COVID-19 patient has normal, mild, or severe anosmia. To achieve this goal, we used fluid-attenuated inversion recovery (FLAIR) Magnetic Resonance Imaging (FLAIR-MRI) and Diffusion Tensor Imaging (DTI) to extract the appearance, morphological, and diffusivity markers from the olfactory nerve. The proposed system begins with the identification of the olfactory …

Hubungan Penyakit Jantung Koroner Dengan Kebugaran Jasmani Pada Jemaah Haji Di Provinsi Dki Jakarta Tahun 2023, Yanti Herawati, Mondastri Korib Sudaryo

Jurnal Epidemiologi Kesehatan Indonesia

Haji adalah ibadah yang membutuhkan jasmani sehat juga bugar. Permenkes terkait tentang Istithaah Kesehatan Jemaah Haji Nomor 15 Tahun 2016 membawa konsekuensi mengedepankan pemeriksaan juga pembinaan kesehatan bagi jemaah haji sehingga mampu menyelesaikan seluruh ritual ibadahnya sesuai syariat Islam. Penelitian ini bertujuan untuk menganalisis hubungan Penyakit Jantung Koroner (PJK) terhadap kebugaran jasmani jemaah haji di Provinsi DKI Jakarta Tahun 2023. Desain studi penelitian menggunakan kohort restrospektif, dengan total sampling sebanyak 4.779 sampel serta menggunakan data sekunder dari aplikasi Siskohatkes Kementerian Kesehatan RI tahun 2023. Kriteria pemilihan sampel adalah responden yang mempunyai data pemeriksaan kesehatan tahap kedua dan hasil pengukuran kebugaran …

Echo Rehabilitation Project: The Context For Developing System Partner Collaboration To Overcome Challenges In Rural Community Neurological Rehabilitation Provision, Angela Gibbon

South West Clinical School Journal

#400WORDS: RESEARCH + ACTION

Perceptions Of Advanced Practitioners In Mental Health: Findings From A Literature Review, Chloe Parkin

South West Clinical School Journal

#400WORDS: RESEARCH + ACTION

Collaborative Learning In Practice (Cliptm) In Mental Health Inpatient Settings: A Survey Of Student Nurses And Registered Nurses’ Experiences, Kerry Siau

South West Clinical School Journal

#400WORDS: CHIEF NURSING OFFICER’S RESEARCH FELLOWS EVIDENCE IMPLEMENTATION PROJECTS

The Chief Nurse Research Fellowship: My Clinical Academic Experience, Lucy Yarnold

South West Clinical School Journal

No abstract provided.

Severe Febrile Neutropenia And Pancytopenia In A Patient With Advanced Hepatocellular Carcinoma Treated With Atezolizumab And Bevacizumab: A Case Report, Shadi Chamseddine, Michael Lapelusa, Kristen Carter, Van Nguyen, Yehia I Mohamed, Yara Sakr, Cristhiam M Rojas-Hernandez, Rikita I Hatia, Manal Hassan, John A Goss, Khaled M Elsayes, Asif Rashid, Ryan Sun, Hop Sanderson Tran Cao, Hesham M Amin, Ahmed O Kaseb

Faculty, Staff and Student Publications

BACKGROUND: Immune checkpoint inhibitors (ICIs), agents that stimulate T-cell function, have become the standard first-line treatment for unresectable hepatocellular carcinoma (HCC). However, they may also cause immune-related adverse events (irAEs), which are rare and have not been extensively reported. Here, we describe a case of severe febrile neutropenia and pancytopenia after atezolizumab plus bevacizumab (atezo/bev) therapy and its treatment course.

CASE DESCRIPTION: The combination of atezo/bev was initiated as the first-line treatment for a man in his early 50s, who was diagnosed with unresectable HCC. The first treatment cycle was administered in the outpatient setting, and the patient developed a …

Impact Of Gut Health And Microbiome On Autism Spectrum Disorder, Sik Yu So, Tor C Savidge

Faculty, Staff and Students Publications

No abstract provided.

Analisis Penerapan Activity-Based Costing Tindakan Debridemen Bedah Pada Diagnosis Tunggal Di Kamar Operasi Rskd Duren Sawit Tahun 2022, Reynaldi Fattah Zakaria, Mardiati Nadjib

Jurnal Ekonomi Kesehatan Indonesia

In 2022, RSKD Duren Sawit has officially held operating room services. The demand for more comprehensive operating room services increased rapidly. The temporary operating room rates were set by adapting the rates of other regional hospitals and the Governor of DKI Jakarta's regulations. There is a huge difference in costs between the hospital rates and the INA-CBGs claim rates, especially for surgical debridement performed in the operating room. One of the factors causing the difference is the undetermined cost for debridement based on the unit cost component. Knowing the unit-cost debridement in the operating room according to the cost per …

Determinan Kegagalan Pengobatan Pada Pasien Tuberkulosis Sensitif Obat Dewasa Di Provinsi Jawa Tengah Tahun 2022, Elizabeth Wulandari, Sudarto Ronoatmodjo

Jurnal Epidemiologi Kesehatan Indonesia

Tuberkulosis (TB) adalah salah satu penyakit menular penyebab kematian tertinggi di dunia. Pada populasi pasien TB, terdapat banyak faktor yang dapat meningkatkan risiko kejadian yang tidak diharapkan dari pengobatan. Tujuan dari penelitian ini adalah untuk mengidentifikasi faktor-faktor yang berhubungan dengan kegagalan pengobatan pada pasien TB dewasa di Provinsi Jawa Tengah pada tahun 2022. Studi cross-sectional ini menganalisis data sekunder dari Sistem Informasi TB (SITB), menggunakan 14.542 sampel yang memenuhi kriteria inklusi dan eksklusi. Pasien TB berusia >15 tahun dan terdapat hasil pengobatan merupakan kriteria inklusi dalam penelitian ini. Kegagalan pengobatan merupakan variabel dependen dan variabel independennya adalah usia, jenis kelamin, …

Gambaran Diagnosis Tbc Di Indonesia Tahun 2020-2022, Siti Zaenab, Sudarto Ronoatmodjo, Muharnis Putri

Jurnal Epidemiologi Kesehatan Indonesia

Tantangan utama dalam pemberatasan TBC di Indonesia ialah mengenai penemuan kasus TBC, diagnosis merupakan salah satu strategi utama dalam penemuan kasus TBC, diperlukan informasi mengenai gambaran ketersediaan akses universal diagnosis TBC di Indonesia tahun 2020-2022 sehingga kasus TBC tersebut dapat diobati sampai sembuh dan tercapainya eliminasi TBC di tahun 2030. Tujuan dari dilakukannya studi ini ialah untuk memberikan gambaran diagnosis TBC yang ada di Indonesia pada tahun 2020-2022, studi dilakukan menggunakan data surveilans TBC (SITB) milik Kementerian Kesehatan RI. Data yang akan dievaluasi merupakan seluruh terduga TBC yang datang ke Fasyankes dan tercatat di SITB. Hasilnya adalah pada tahun 2020 …

Hubungan Riwayat Komplikasi Kehamilan Dengan Kejadian Perdarahan Pasca Salin Di Indonesia (Analisis Data Survei Demografi Dan Kesehatan Indonesia 2017), Dewiyana Dewiyana, Trisari Anggondowati

Jurnal Epidemiologi Kesehatan Indonesia

Perdarahan Pasca Salin (PPS) merupakan salah satu penyebab utama kematian ibu secara global dan di Indonesia. Berdasarkan Survei Demografi dan Kesehatan Indonesia (SDKI) 2017, masalah kesehatan terbesar yang dikhawatirkan oleh para ibu yang dapat membahayakan seorang wanita ketika melahirkan adalah ibu mengalami PPS (28%). Memprediksi risiko PPS adalah bagian penting dari skrining prenatal dan penilaian pada kehamilan dan persalinan sangat bergantung pada akurasi riwayat kehamilan. Studi cross-sectional ini bertujuan mengetahui hubungan antara riwayat komplikasi kehamilan dengan perdarahan pasca salin di Indonesia menggunakan SDKI 2017. Responden adalah Wanita Usia Subur (WUS) 15-49 tahun yang melahirkan anak terakhir secara per vaginam sebelum …

Determinan Kejadian Hipertensi Pada Sopir Angkot Di Terminal Depok, Khairal Ummah, Fajaria Nurcandra, Balqis Hiri Bahasoan

Jurnal Epidemiologi Kesehatan Indonesia

Hipertensi masih menjadi masalah kesehatan masyarakat dan menjadi faktor penyebab berkembangnya penyakit kardiovaskular. Indonesia memiliki prevalensi hipertensi tertinggi di kawasan Asia Tenggara hipertensi yaitu sebesar 41%. Kota Depok menjadi wilayah dengan prevalensi hipertensi tertinggi yaitu sebesar 22,7%. Oleh karena itu tujuan dilakukannya penelitian ini adalah untuk mengetahui faktor-faktor hipertensi pada sopir angkot di terminal Depok. Studi cross sectional dengan jumlah sampel 84 angkot yang diwawancara menggunakan kuesioner dan tensimeter yang dilakukan pada bulan Mei-Juni 2018. Sopir-sopir tersebut dipilih secara purposive sampling dan dilakukan analisis menggunakan uji regresi logistik. Proporsi hipertensi pada sopir angkot yaitu sebesar 64,5%. Variabel yang memiliki hubungan …

Hubungan Antara Partisipasi Dalam Pengambilan Keputusan Kesehatan Perempuan Dengan Kehamilan Yang Tidak Diinginkan, Maria Anastasia Audrey, Sudarto Ronoatmodjo

Jurnal Epidemiologi Kesehatan Indonesia

Prevalensi Kehamilan Tidak Diinginkan (KTD) di Indonesia mencapai 10,7% pada tahun 2021. Pada wanita yang sudah menikah, keputusan kesehatan mencakup keputusan tentang kontrasepsi, yang idealnya melibatkan partisipasi perempuan bersama suaminya agar dapat dilakukan secara konsisten sehingga dapat mencegah KTD. Namun, data tahun 2017 menunjukkan proporsi pengambilan keputusan kesehatan perempuan yang dilakukan perempuan bersama suami hanya sebesar 43,7%. Penelitian ini bertujuan untuk mengetahui hubungan antara partisipasi bersama antara istri dan suami dalam pengambilan keputusan kesehatan perempuan dengan terjadinya KTD. Penelitian ini menggunakan desain studi crosssectional dengan menganalisis data Survei Demografi dan Kesehatan Indonesia tahun 2017. Kriteria inklusi sampel adalah perempuan yang …

Analisis Pembiayaan Berdasarkan Lama Rawat Pasien Bpjs Diabetes Melitus Tipe Ii Komplikasi Sirkulasi Perifer Di Rsu Pku Muhammadiyah Bantul, Firman Firman, Kartika Lestari

Jurnal Ekonomi Kesehatan Indonesia

Length of stay (LOS) can increase hospital rates and become a cost issue for patients, potentially resulting in a discrepancy between hospital rates and INA-CBGs rates at the hospital. This study aims to determine the difference between the actual costs and BPJS claim costs for diabetic patients based on the length of stay and class level. The research method is observational with a descriptive approach. The data collection technique used retrospective medical record data from 50 patients. The results showed that the largest average difference between hospital costs and BPJS claim costs was for patients with a length of stay …

Gambaran Klaim Pelayanan Dialisis Di Rumah Sakit Dan Rekomendasi Kebijakan Di Level Daerah: Studi Kasus Kota Pematangsiantar, Syarif Rahman Hasibuan, Chandra Istanti Prasetyo, Ede Surya Darmawan, Vetty Yulianty Permanasari

Jurnal Ekonomi Kesehatan Indonesia

Chronic kidney disease is a global health issue affecting more than 10% of the world's population and poses a significant disease burden, especially in developing countries. In Indonesia, the National Health Insurance program (JKN) has enabled access to dialysis care for patients with chronic kidney failure, but it also presents challenges in sustaining financing. This study aims to analyze the trends in dialysis service claims in Pematangsiantar City during the period from 2017 to 2022 and project the service needs until 2025. The research design is descriptive-analytic, using claim data from BPJS Health related to dialysis procedures. Analysis is conducted …

Assessing The Impact Of Tuberculosis On Economic Growth In Asean Countries: A Conceptual Framework And Panel Data Analysis, Agus Fitriangga, Alex Alex

Jurnal Ekonomi Kesehatan Indonesia

Tuberculosis (TB) remains a major global health issue, particularly in Southeast Asia, where its impact extends beyond public health to affect economic performance. This study evaluates the economic implications of TB incidence on gross domestic product (GDP) growth across eight ASEAN countries from 2000 to 2020. We employed a panel data regression approach, utilizing Common Effect Model (CEM), Fixed Effects Model (FEM), and Random Effects Model (REM) to analyze the relationship between TB incidence and economic growth. The dataset included annual GDP figures, TB incidence rates, foreign direct investment (FDI), labor force size, and trade openness, sourced from international databases. …

Analysis Of Accessibility Of People With Sensory Disabilities In Rsud Pasar Minggu, Daffaldo Suryoputra, Masyitoh Basabih, Fify Mulyani

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

People with a disability is someone who has conditions, whether physically and mentally that make a person experience difficulty in certain conditions and interact with their environment. Pasar Minggu Regional Hospital (RSUD Pasar Minggu) has achieved a general patient satisfaction indicator with satisfaction rate of 90% in 2022. This satisfaction indicator mainly comes from infrastructure and facility factors, along with the competence of service providers and costs. As a regional referral hospital, this hospital certainly has patients with physical limitations due to disabilities or illnesses. To ensure patient satisfaction can also be felt by patients with physical limitations, this study …

Strategi Optimalisasi Klaim Jaminan Kesehatan Nasional Di Unit Casemix Rumah Sakit “X” Blitar, Nurfathina Syahira, Achmad Jaelani Rusdi, Prima Soultoni Akbar

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The funding for patient care of participants of the Social Security Administering Body (BPJS) Health in hospitals is carried out through a claim mechanism. This study aims to design a strategy to optimize the claims for patient care costs for BPJS participants at Hospital "X" in Blitar. The study is conducted with a descriptive qualitative approach, and data collection is done through interviews and Focus Group Discussions (FGD). The informants consist of a doctor and four coders in the casemix unit. The study begins with an analysis of the claim service system situation, focusing on strengths, weaknesses, opportunities, and threats …

Analisis Implementasi Aplikasi Mobile System Pada Sistem Informasi Manajemen Di Rumah Sakit Umum Daerah (Rsud) Budhi Asih, Annisa Apriani Safitri, Mustakim Mustakim

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Hospital Information System (HIS) or Hospital Management Information System (SIMRS) is important in supporting the entire hospital process through information technology. Budi Asih Regional Hospital has a Hospital Information System in its management but still has various issues and challenges in its implementation. This study uses qualitative methods, informant selection with purposive sampling, and data collection techniques through in-depth interviews, observations, and document analysis. Information systems are part of organizational resources for decision-making regarding leadership needs. The Management Information System must be designed by considering data architecture including automated codification in an integrated manner such as statistics, mapping for further …

Method Development, Validation And Forced Degradation Studies Of Dapagliflozin And Pioglitazone Hydrochlorides In Synthetic Mixtures By Rp-Hplc, Tarang Patel, Harpalsinh Rathod

Discovery Day

A simple, sensitive, robust, precise, and efficient RP-HPLC approach for the simultaneous determination of Dapagliflozin and Pioglitazone Hydrochloride in Synthetic Mixture. As per ICH Q2 (R1) guidelines, the final chromatographic conditions were Optimized with a mobile phase ratio of (25:75% v/v) in ACN: Potassium Dihydrogen Phosphate Buffer (pH 4) was adjusted by adding OPA at a flow rate of 1 mL/min, column temperature of 30 °C, injection volume of 20 μL, Kromstar Vertex C18 analytical column, and UV detection at 228 nm wavelength. Dapagliflozin and Pioglitazone Hydrochloride reported retention times of 3 min and 6.5 min, respectively. Validation of a …

Disability Among Older Adults With Hypertension In Southeast Asia: A Scoping Review, Utoomporn Wongsin, Arnat Wannasri, Dichapong Pongpattrachai, Tuo-Yu Chen

Journal of Demography

Background: The prevalence of chronic disease and disability is expected to increase when age increases. This study aims to investigate the published articles related to disability among older adults living with hypertension in Southeast Asia.

Study Design: A scoping review

Data source: Web of science, Pubmed, CINAHL ,Cochrane and a google search, from 2000 to 2023.

Results: There were six observational studies from Indonesia, Vietnam, Malaysia, and Thailand met our inclusion criteria. The studies mainly focus on investigating the prevalence, risk factors and sex difference in risk factors associated with disabilities among the older adults.

Conclusion: Our scoping review has …

Thoracic Canal Morphology On Preoperative Magnetic Resonance Imaging In Spinal Cord Stimulation Patients, Kevin Hines, Christian Tran, Anusha Koka, Nikolaos Mouchtouris, Karim Hafazalla, Ellina Hattar, Chengyuan Wu, Ashwini Sharan

Department of Neurosurgery Faculty Papers

INTRODUCTION: In high-frequency spinal cord stimulation anatomic placement targeting of the T9-10 disc space is based on "empiric" results that are best replicated with coverage broadly from T8 to T10. This study contains the largest cohort of patients evaluating low thoracic morphology and seeks to address the lack of MRI morphological analysis in literature.

METHODS: This study was a retrospective review of a database of 101 consecutive patients undergoing permanent implant of thoracic SCS for chronic pain. Measurements were carried out on preoperative MRI imaging. Anteroposterior (AP) and lateral dimensions of the spinal cord as well as dural sac were …

Neonatal Nurses’ Intention To Stay In The Nicu, Carolyn Penn-Griffin

Walden Dissertations and Doctoral Studies

Neonatal nursing leaders and national health care organizations within the United States are concerned about the recent shortage of skilled and experienced neonatal intensive care unit (NICU) nurses that may reduce the quality of care delivered to NICU patients. NICU nurses are passionate about caring for premature and ill full-term infants and providing educational and emotional support for their parents, some NICU nurses remain in the NICU long-term, yet others contemplate leaving the specialty. The purpose of this qualitative interpretative phenomenological research guided by Martin Fishbein and Ajezen’s theory of reasoned action was to explore the lived experiences of NICU …

Proteoglycans Of Basement Membranes: Crucial Controllers Of Angiogenesis, Neurogenesis, And Autophagy, Maurizio Mongiat, Gabriel Pascal, Evelina Poletto, Davion M. Williams, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Anti-angiogenic therapy is an established method for the treatment of several cancers and vascular-related diseases. Most of the agents employed target the vascular endothelial growth factor A, the major cytokine stimulating angiogenesis. However, the efficacy of these treatments is limited by the onset of drug resistance. Therefore, it is of fundamental importance to better understand the mechanisms that regulate angiogenesis and the microenvironmental cues that play significant role and influence patient treatment and outcome. In this context, here we review the importance of the three basement membrane heparan sulfate proteoglycans (HSPGs), namely perlecan, agrin and collagen XVIII. These HSPGs are …

Risk Of Anthracycline-Induced Cardiac Dysfunction In Adolescent And Young Adult (Aya) Cancer Survivors: Role Of Genetic Susceptibility Loci, Lily K Stafford, Xiaohui Tang, Amanda Brandt, Jianzhong Ma, Jose Banchs, J Andrew Livingston, Michael E Roth, Alanna C Morrison, Michelle A T Hildebrandt

Faculty, Staff and Student Publications

There is a known genetic susceptibility to anthracycline-induced cardiac dysfunction in childhood cancer survivors, but this has not been adequately shown in adolescent and young adult (AYA) patients. Our aim was to determine if the previously identified variants associated with cardiac dysfunction in childhood cancer patients affect AYA cancer patients similarly. Forty-five variants were selected for analysis in 253 AYAs previously treated with anthracyclines. We identified four variants that were associated with cardiac dysfunction: SLC10A2:rs7319981 (p = 0.017), SLC22A17:rs4982753 (p = 0.019), HAS3:rs2232228 (p = 0.023), and RARG:rs2229774 (p = 0.050). HAS3:rs2232228 and SLC10A2:rs7319981 displayed significant effects in our AYA …