Medicine and Health Sciences Commons^™

Transcriptomic Analysis Reveals The Anti-Cancer Effect Of Gestational Mesenchymal Stem Cell Secretome, Salvatore Vaiasicca, Gianmarco Melone, David W James, Marcos Quintela, Jing Xiao, Seydou Yao, Richard H Finnell, Robert S Conlan, Lewis W Francis, Bruna Corradetti

Faculty, Staff and Students Publications

The environment created during embryogenesis contributes to reducing aberrations that drive structural malformations and tumorigenesis. In this study, we investigate the anti-cancer effect of mesenchymal stem cells (MSCs) derived from 2 different gestational tissues, the amniotic fluid (AF) and the chorionic villi (CV), with emphasis on their secretome. Transcriptomic analysis was performed on patient-derived AF- and CV-MSCs collected during prenatal diagnosis and identified both mRNAs and lncRNAs, involved in tissue homeostasis and inhibiting biological processes associated with the etiology of aggressive cancers while regulating immune pathways shown to be important in chronic disorders. Secretome enrichment analysis also identified soluble moieties …

Early Depletion Of Gut Microbiota Shape Oligodendrocyte Response After Traumatic Brain Injury, Kirill Shumilov, Allen Ni, Maria Garcia-Bonilla, Marta Celorrio, Stuart H Friess

2020-Current year OA Pubs

BACKGROUND: This study is a cost-effectiveness study of two implementation strategies designed to train therapists in college and university counseling centers to deliver interpersonal psychotherapy. Costs of implementing a train-the-trainer (TTT) strategy versus an expert consultation strategy were estimated, and their relative effects upon therapist outcomes were calculated and compared.

METHODS: Twenty four counseling centers were recruited across the United States. These centers were randomized to either a TTT (experimental) condition, in which an in-house therapist trained other center therapists, or an expert consultation condition, in which center therapists participated in a workshop and received 12 months of ongoing supervision. …

Electroencephalogram Alpha Oscillations In Stroke Recovery: Insights Into Neural Mechanisms From Combined Transcranial Direct Current Stimulation And Mirror Therapy In Relation To Activities Of Daily Life, Chia-Lun Liu, Ya-Wen Tu, Ming-Wei Li, Ku-Chou Chang, Chih-Hung Chang, Chih-Kuang Chen, Ching-Yi Wu

2020-Current year OA Pubs

The goal of stroke rehabilitation is to establish a robust protocol for patients to live independently in community. Firstly, we examined the impact of 3 hybridized transcranial direct current stimulation (tDCS)-mirror therapy interventions on activities of daily life (ADL) in stroke patients. Secondly, we explored the underlying therapeutic mechanisms with theory-driven electroencephalography (EEG) indexes in the alpha band. This was achieved by identifying the unique contributions of alpha power in motor production to ADL in relation to the premotor cortex (PMC), primary cortex (M1), and Sham tDCS with mirror therapy. The results showed that, although post-intervention ADL improvement was comparable …

Langerhans Cell Histiocytosis: Nacho Update On Progress, Chaos, And Opportunity On The Path To Rational Cures, Kevin Bielamowicz, Peter Dimitrion, Oussama Abla, Simon Bomken, Patrick Campbell, Matthew Collin, Barbara Degar, Eli L Diamond, Olive S Eckstein, Nader El-Mallawany, Mark Fluchel, Gaurav Goyal, Michael M Henry, Michelle Hermiston, Michael Hogarty, Michael Jeng, Rima Jubran, Joseph Lubega, Ashish Kumar, Stephan Ladisch, Kenneth L Mcclain, Miriam Merad, Qing-Sheng Mi, D Williams Parsons, Erin Peckham-Gregory, Jennifer Picarsic, Zachary D Prudowsky, Barrett J Rollins, Peter H Shaw, Birte Wistinghausen, Carlos Rodriguez-Galindo, Carl E Allen, North American Consortium For Histiocytosis

Faculty, Staff and Students Publications

Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder characterized by lesions with CD1a-positive/Langerin (CD207)-positive histiocytes and inflammatory infiltrate that can cause local tissue damage and systemic inflammation. Clinical presentations range from single lesions with minimal impact to life-threatening disseminated disease. Therapy for systemic LCH has been established through serial trials empirically testing different chemotherapy agents and durations of therapy. However, fewer than 50% of patients who have disseminated disease are cured with the current standard-of-care vinblastine/prednisone/(mercaptopurine), and treatment failure is associated with long-term morbidity, including the risk of LCH-associated neurodegeneration. Historically, the nature of LCH-whether a reactive condition versus …

A Presentation Of Acute On Chronic Pancreatitis Complicated By Pancreaticopleural Fistula Leading To Bilateral Exudative Pleural Effusions And Empyema, Ashruta Patel, Do, Ms

The Journal of Integrated Primary Care

This case report highlights a rare but serious complication of acute pancreatitis, where pancreatic juice drains into the pleural space, causing bilateral exudative pleural effusions and potentially leading to empyema. The patient's history of alcohol abuse and splenic vein thrombosis likely contributed to the development of this complication. The clinical presentation, including progressive shortness of breath and pleuritic chest pain, along with findings on examination and imaging, prompted further investigation. The MRI findings of a pancreaticopleural fistula, along with a pseudocyst, were significant in diagnosing the condition. Treatment involved a multidisciplinary approach, including antibiotic therapy, chest tube placement to drain …

A Mixed Methods Acceptability And Feasibility Study Of A Patient-Initiated Approach To Increasing Weight Communication In Primary Care, Jocelyn E. Remmert, Leon Mccrea, Nicole T. Crane, Adam Gilden, Meghan L. Butryn

The Journal of Integrated Primary Care

Background: Weight discussions between patients and physicians can have a positive impact on patients’ health, yet they occur infrequently in primary care. No study to date has promoted patient-initiated weight discussions. This study aimed to test the feasibility, acceptability, and explore trends of the effect of a waiting room-based pamphlet intervention to promote patient-initiated weight discussions.

Methods: Adults (n=60) with overweight or obesity attending a primary care appointment were recruited from the waiting room and randomized to receive the intervention pamphlet or to a non-intervention control condition. All participants attended their appointment and completed post-appointment assessments.

Results: Three …

Case Report Of A Brief Modular Anxiety Intervention For Integrated Primary Care: Addressing Clinician Feasibility Concerns And Barriers To Using Manualized Treatments, Katherine Buckheit, Robyn L. Shepardson, Luke Mitzel, Risa B. Weisberg, Stephen A. Maisto, Jennifer Funderburk

The Journal of Integrated Primary Care

Individuals with anxiety symptoms commonly present in primary care settings and prefer behavioral health (versus pharmacotherapy) treatment, but behavioral health interventions are underutilized. Primary care behavioral health (PCBH) models, in which embedded behavioral health providers deliver behavioral treatment in primary care, may help address the gap in provision of anxiety treatment. However, evidence-based anxiety treatment options feasible for delivery in primary care are limited, and clinicians often report concerns about using manualized interventions. Recent recommendations by the U.S. Preventative Services Task Force to increase anxiety screening among adults in primary care may result in increased identification of individuals with anxiety …

Employing Interactive Architecture Techniques In Architectural Design Methodologies To Retrieve Ancient Egyptian Identity, Dina Elwy Aly Hamed Hussein Dr. Lobna Abd-Allah Abd-Elfattah Agha , Dr. Azza Sobhi Ragab Elsakka

Journal of Engineering Research

Architectural projects often rely on modern technologies like smart architecture and environmental treatments, neglecting the principles and philosophy that reflect civilization, ideas, culture, and traditions. This leads to short-lived buildings that depend on these technologies without any purpose of preserving them. Technicians must constantly renew technology to improve production and without benefits, as threats of superior artificial intelligence have been warned, that autonomous machines may perform tasks without programmers understanding how to reach this level. Instead of relying solely on environmental or smart technology, we should make technology serve the design idea rather than relying solely on it. Considering this, …

The Effect Of Lighting In Color In The Interior Space Of The Residential Unit, Abd Elbary Eldininy Abd Elbary Eldininy

Journal of Engineering Research

ABSTRACT: Humanity is spending more and more time indoors, both at work and at home - with studies showing that we now spend 87% of our lives indoors. Residential environ ments both positively affect the mood and well-being of its occupants, just as places with poor and uncomfortable lighting and colors can make life miserable. This is why we are interested in this issue. The importance of knowing the issues of lighting and colors in order to obtain a well thought-out interior design. The interior designer has the ability to control in the quality of lighting of various types, artificial …

Green Facade Strategy To Mitigate Heat Islands, Arch. Aya Gamal Abdel Hamid Muhammad Prof. Mai Wahba Madkour... Dr. Rania Elghamry Ashmawy Tolba Elakab

Journal of Engineering Research

In the beginning of the twentieth century and the occurrence of the economic crisis that accompanied by a climate crisis, that one of its indicators the rise in temperatures and the formation of hot zones, especially in crowded cities, including Cairo in particular, as it is considered one of the crowded cities in the world, and this noticeable rise in temperatures in Some areas where hot zones form are called heat islands. This results because of the nature of the urban environment, which has a high building density, little natural landscape, and human and industrial activities that has a negative …

Light Structure Building Technology Towards Sustainable Environmental Design, Sally El-Sayed Prof. Dr. Mai Wahba Madkour2, Prof. Dr. Marwa Ahmed Kamer El-Dawla3

Journal of Engineering Research

The building and construction industry is one of the most important sectors globally , as it plays a vital role in providing housing and infrastructure that meets the needs of various communities , However , this industry is considered one of the largest contributors of negative environmental impacts in terms of consuming huge amounts of natural resources in an unsustainable manner and a subsequent increase in energy consumption .Therefore, it was necessary to find solutions and explore for new and sustainable construction methods to alleviate these problems .This research paper will focus on the use of light buildings and their …

Available Building Technology As A Tool For Developing Construction And Structure Systems., J. Q. . Nader Ibrahim Ismael

Journal of Engineering Research

The research aims to study the impact of available building technology in each era in the development of the constructional thought and implementation techniques used and its impact on the development of different types of buildings, through the emergence of different types of buildings and the development of buildings types in terms of shape and height, through the development of building materials used Whether construction materials or finishing materials, as well as used construction techniques and equipment, and the impact of all on the development of construction thought and construction systems through different eras . The research also represents an …

Increasing Occupancy Rates In Coastal Tourism Development At The Regional Level In Support Of A Sustainable Quality Of Life In Egypt, عبدالرحمن محمد عبدالقادر موسي

Journal of Engineering Research

إن استغلال الفراغات التي تمثل أكثر من 80% من مساحة المنتجعات السياحية الساحلية في الأنشطة الرياضية والترفيهية والثقافية والاجتماعية وتوفير الخدمات المختلفة عن طريق دعم الخدمات الإلكترونية التي تساعد الزائرين في قضاء وقت أكبر بتلك القري السياحية، مع تعلم السباحة وركوب الدرجات والتجديف والتسلق وركوب الخيل دعما لجودة الحياة ، حيث التمتع بالهواء المتجدد القادم من البحر بعيدا عن التلوث والضوضاء، ولزيادة الاستفادة والدعم يتم توفير وحدات فندقة لغير الملاك لزيادة الزوار والاتفاق مع المدارس والجامعات لتنشيط تلك الرحلات للشواطئ وممارسة الأنشطة المميزة لهؤلاء الشباب والاستفادة من الخدمات الجيدة والفراغات الصحية والهواء المتجدد وتعلم الرياضات الشاطئية المفيدة وذلك الاتجاه من …

Green Architecture Strategies To Achieve Sustainability In Buildings, Azza Sobhi Ragab Elsakka J. Q. Assos., Menna Ashraf Saeid Ali

Journal of Engineering Research

في الوقت الحالي توجد حاجة مُلحة لتطبيق معايير الاستدامة التي تعني المحافظة على الموارد الحالية و استخدامها بحيث لا تقل استفادة الأجيال القادمة من تلك الموارد ، و للاستدامة عدة جوانب لتطبيقها أحد تلك التطبيقات هي العمارة الخضراء ، العمارة الخضراء مرت بعدة مراحل بدءاً من القرن السابع عشر ( منذ العصر العثماني الاسلامي ) من خلال وجود بعض الأساليب الغير مباشرة في التصميم التي توفر التهوية و الإضاءة الطبيعية و حتى عصرنا هذا، حيث وُجد تقييم لأداء المبنى الأخضر من حيث أسلوب التصميم و الإنشاء بحيث لا يؤثر على البيئة تأثير سلبي و ما زال التطوير مستمر في إنشاء …

Enhancing Daylight Using Sustainable Natural Lighting Techniques In Modern Architecture, سارة حسني شعلان أ.م.د/ لبني عبد الفتاح أغا

Journal of Engineering Research

Natural lighting is one of the basic criteria for the architectural design process. It is one of the most important data that contributes to the design of architectural spaces and the manifestation of aesthetic values. In light of the global technological development and the scientific and information revolution, the role of the architect comes in highlighting the importance of natural lighting and its positive role in human biology, and reducing effort and psychological pressure in the event of Its use is an alternative to artificial lighting, as it increases human efficiency and achievement at work, in addition to giving a …

The Impact Of Green Infrastructure On Urban Heat Island Phenomenon In Existing Cities, Neveen Youssef Azmy Basant Elsayed Abu-Farrag, Walaa Abou El-Haggag Mehanna

Journal of Engineering Research

Rapid urbanization and overpopulation, along with a lack of green space, led to an increase in air temperature, lowering the rate of thermal comfort in dense urban areas, decreasing air quality, and increasing the urban heat island (UHI) phenomenon, particularly in existing cities. As a result, the research aims to reduce the UHI effect and improve the thermal performance of existing Egyptian cities by adopting green infrastructure (GI) principles and demonstrating their effectiveness on the UHI phenomenon. This research concentrates on the UHI phenomenon as one of the environmental issues facing urbanization and includes a review of green infrastructure (GI) …

Optimizing Fenestration Systems In Residential Buildings: A Parametric Analysis Of Egyptian Energy Codes' Impact On Thermal Comfort, Wafik El-Menshawi Ali F. Bakr , Amira A.Fathi

Journal of Engineering Research

- Fenestration systems, such as windows, doors, and skylights, play a crucial role in improving thermal comfort and reducing energy consumption in buildings. In Egypt, the energy code establishes standards for fenestration systems to promote energy efficiency and carbon emission reduction. Residential buildings account for a significant portion of total energy consumption, making the optimization of fenestration systems essential. This research focuses on studying the optimization of fenestration systems in Egyptian residential buildings through parametric analysis, considering energy standards and their impact on total energy gain and thermal comfort. The paper examines existing energy codes for fenestration systems and explores …

Towards Green Cities As An Approach To Achieve Climate Change Adaptation, Noha H. Hefnawy Nouran M. Ibrahim

Journal of Engineering Research

Climate change is a complicated problem and there is an urgent need for climate change adaptation. Cities are the primary drivers of social, economic, and technical progress. Green Cities are cities that show high environmental performance relative to adapting risks derived from climate change while maximizing the economic and social co-benefits. The Authors adopted a data collection strategy to review the issues, and difficulties caused by climate change and how green cities could assist in addressing them, then adopted a case study analysis to analyze the strategies used by Sharm El Sheikh in the transition to green city. The study …

Using Recycled Materials Towards Sustainable, Eco-Friendly Building In Hot Regions – A Review, Mai W. Madkour Hosny A. Dewer, And Shaimaa M. Refaat

Journal of Engineering Research

Due to population growth and increased urban activity, there is a rise in waste production, which poses health and environmental risks. Additionally, the extraction and transportation of natural resources to places of employment require significant energy consumption, and the world has therefore moved to seek new alternatives away from traditional construction methods by recycling building materials such as concrete, brick, glass, wood, etc., or using new building materials such as rice straw, plastics, corks, etc., taking into account architectural design. The research is aimed at demonstrating that recycled materials have the potential to perform a better environmental performance by preserving …

Sustainable Design In Open Service Campus Areas (The American University In Cairo As A Model), مصطفى منصور عبد المجي أ.م.د. زينب لطفى عبدالحكيم خليفة

Journal of Engineering Research

إن الجامعات المستدامة تعد اتجاهاً مستقبلياً معاصراً لابد أن تحرص مؤسسات التعليم العالي على تبني مبادئه، ووضع خارطة طريق مستقبلية، وتتطلب استدامة الجامعات مواجهة الكثير من التحديات الجغرافية لضمان توفير بيئة آمنه ومريحة مع الحد الأدنى من الهدر، وإيلاء اهتمام خاص لاحتياجات الطلاب وجميع العاملين بالجامعة، والقدرة على تخطيط وإدارة الحيزات الخدمية المفتوحة بها وإقامة المنشآت المستدامة.

Agile Vs Waterfall As An Approach For Effective Management Practices In Fit Out Projects (Preferences Of Project Managers), Moutaz M. El Baz 1

Journal of Engineering Research

Optimum time, cost & quality are the key objectives in managing fit-out projects. Waterfall and Agile are the most common approaches for achieving the project objectives. To determine the optimal managerial approach for fit-out projects, it was essential to study the project life cycle & phases, waterfall & agile methodologies & phases and the project management performance indicators. To achieve the research goals, a data gathering/analysis performed among three steps. Firstly, by performing qualitative research through semi-structured interviews with project management experts to verify the research hypothesis. Secondly, through studying the project & project management life cycle, phases and characteristics …

Improving Home Designs For Disease Prevention In Gated Communities And Satisfying Living Space Needs In Egypt: A Post-Pandemic Living Assessment, A. Moustafa Kamel Neveen Youssef Azmy, Shahira Sharaf Eldin

Journal of Engineering Research

Abstract Pandemics such as SARS and COVID-19 have highlighted the importance of preventing and controlling diseases. Virus transmission in residential buildings, especially multi-unit apartment complexes, has prompted calls for innovative housing designs. While Western countries prioritize physical and mental health in residential building design, China focuses on comfort, aesthetics, appearance, and lifestyle.

Studying The Problems Of Delayed Receipt Of University Buildings In Egypt During The Corona Pandemic, أ.د / مروه قمر الدولة أ.د / لبنى أغا

Journal of Engineering Research

على الرغم من وجود العديد من الدراسات السابقة في مجال تأخير مشاريع البناء. إلا أن هناك أبحاث محدودة جدًا تتناول تأثير كورونا على عوامل تأخر مشاريع البناء. وعليه فإن هذا البحث يتناول آراء المتخصصين حول تأثير جائحة كورونا على العوامل المسببة للتأخير في عملية البناء في مصر. ومن المتوقع أن تساهم نتائج هذا البحث في دراسة العوامل المسببة لهذا التأخير ومحاولة تقديم بعض التوصيات التي تساهم في وضع الخطط المستقبلية لمواجهة الظروف الاستثنائية المماثلة، يهدف هذا البحث إلى قياس أهمية العوامل المسببة للتأخير في عمليات البناء في مصر على مستوى المباني الجامعية بعد جائحة كورونا، وللوصول الى ذلك الهدف اتخذت …

The Design Of The Outer Casing Is Compatible With The Hot Climate Environment, حازم عز الدين قاسم نوبى محمد حسن مصطفى محمد سيد

Journal of Engineering Research

تعتبر المبانى العالية أحد أقل أنماط المبانى توافقاً مع البيئة والمناخ، وذلك بسبب إنعزالها عن النسيج العمرانى المحيط وتعرضها للعديد من العوامل المناخية بشكل أكبر من المبانى المنخفضة، لذا يعتبر الغلاف الخارجى هو العنصر الأهم فى تصميم المبنى العالي لكونه بمثابة الجدار الفاصل بين البيئة الخارجية ذات الظروف المناخية القاسية وبين البيئة الداخلية التى يجب الوصول فيها لراحة المستخدم الحرارية، حيث يعد الغلاف الخارجى هو المسئول عن ما يقرب من 60% من إجمالى الطاقة التى يستهلكها المبنى العالى وذلك فى أعمال التبريد والتهوية الصناعية [1].

Design Characteristics Of The External Envelope Of Modern High-Rise Buildings In Egypt: Concepts And Indicators Of Energy Performance, حازم عز الدين قاسم ، نوبى محمد حسن، مصطفى محمد سيد

Journal of Engineering Research

إعتمدت الدولة المصرية فى الآونة الأخيرة نمط المبانى العالية فى مخططاتها لمراكز مدن الجيل الرابع الجديدة الجارى إنشاؤها فى العديد من المناطق، وذلك فى إطار سعى الدولة لتغيير الخريطة العمرانية والتوسع في الإستثمار العقاري وخلق مجتمعات مواكبة للتطور العمراني والتكنولوجي بما يتوافق مع رؤية مصر٢٠٣٠، ومع البدء فى ظهور وإعتماد العشرات من مشروعات المبانى العالية فى مصر، أصبح من الضرورى دراسة تصميم الغلاف الخارجى لتلك المبانى ومدى ملاءمته للمناخ والبيئة المحلية، وذلك بهدف الوصول لأفضل أداء للطاقة وأعلى كفاءة للإستهلاك.

An Analytical Study Of Key Performance Indicators For Knowledge Management In Construction Companies, Marwa. M. Ahmed Ayman A.E. Othman, Essam Eldin. K. Mahrous

Journal of Engineering Research

The construction and building industry plays a pivotal role in both national and global economies, necessitating a focused approach in knowledge management (KM) strategies amid current market disruptions and economic uncertainties. For construction companies to plan and develop effective KM strategies, they must be measured and incorporated within the key performance indicators (KPIs) relevant to construction companies. This research paper aims to review literature on knowledge management performance indicators (KM PIs) and rank their importance within the KPIs of contracting companies. Statistical analysis revealed that previous studies neglect KM PIs, such as, as some important techniques for KM, such as …

Heritage Preservation In Egyptian Villages And Centers, Azza Elsakka Ahmed Abdalwahaab , Ebtehal Fady Shareef

Journal of Engineering Research

Heritage holds deep significance as a collective memory and a source of pride for any society. However, in today's world, it has evolved beyond its symbolic status and emerged as a crucial factor in human development across various dimensions. Preserving and restoring heritage has thus become an urgent issue that demands extensive cooperation between governments, international society, and community associations.

Eco-Urbanism: Integrating The Transformation Of Sustainability Into City Design, Mira Ibrahim Helmi

Journal of Engineering Research

Eco-Urbanism, as a contemporary approach to city design, strives to seamlessly embed sustainability into the very fabric of urban environments. This abstract delves into the fundamental principles & aspirations of Eco-Urbanism, illustrating its commitment to catalysing a paradigm shift that harmonizes ecological, economic, social dimensions within cities. In a world increasingly defined by urbanization and ecological challenges, Eco-Urbanism emerges as an imperative response to the imperative for sustainable urban planning. It envisions cities that are not merely centres of growth but are purposefully designed to coexist with and protect their natural surroundings, nurture economic vitality, and champion social inclusivity. Key …

Assessing The Carbon Footprint And Environmental Consequences Of High-Pressure Laminate Utilization., Mira Ibrahim Helmi

Journal of Engineering Research

High-Pressure Laminate (HPL) stands as a prominent engineered decorative surface material, comprising layers of paper, resin, laminate, widely utilized in furniture, countertops, flooring, and wall panels. This study investigates the environmental impact of HPL through the lens of its carbon footprint, a metric quantifying the carbon dioxide emissions associated with its entire life cycle. A notable finding from the European Panel Federation (EPF) suggests that the carbon footprint of HPL approximates 1.2 kg CO2 eq/m2, revealing the emission intensity per square meter of produced material. [1]

Diversity In Harmony: Creating The Built Environment’S Future, Doaa Mustafa Hashim Abu Zaid Ahmed Albadri

Journal of Engineering Research

The research paper investigates the relationship between the architectural history , innovative design and artifical intelligence ( AI) in shaping the built environment of the future. It investigates architects' ongoing efforts to push past design limitations using AI, with a focus on the expressive capacity of historical architectural materials. It addresses the transformation nature of generative design, emphasizing an iterative process using AI tools. The research paper makes a link between generative design as well as emerging forms of architecture by referencing the Dancism Movement using AI Midjourney tool. A case study demonstrates DANCISM Movement patterns, redefining high-rise buildings by …