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Full-Text Articles in Medicine and Health Sciences

Extra Of Extracorporeal: Use Of Vv-Ecmo In Complex Tracheal Ring Resection Surgery, Saurabh Ashok Holamb Mr, Ravinath Swami Mr May 2026

Extra Of Extracorporeal: Use Of Vv-Ecmo In Complex Tracheal Ring Resection Surgery, Saurabh Ashok Holamb Mr, Ravinath Swami Mr

Journal Of Indian Physician Associates

 Abstract

Background:

Tracheal stenosis may arise from congenital malformation, trauma, prolonged intubation, or malignancy. Surgical correction of such lesions poses a major challenge, especially when airway management becomes difficult due to the location and extent of narrowing.

Case Summary:

We report a case of a 64-year-old male with circumferential thickening of the trachea at the D2–D3 level, exhibiting a 1.3cm long segmental narrowing. The patient underwent tracheal ring resection with veno-venous extracorporeal membrane oxygenation (VV-ECMO) support. Two apnea periods were maintained intraoperatively, totaling 3.5 hours, with stable hemodynamics and 100% oxygen saturation throughout. ECMO support was continued overnight as a …


Stereotactic Radiosurgery For Unruptured Arteriovenous Malformation Of The Left Medial Temporal Lobe In A Young Female, Muhammed Suhail S, Gajalakshmi M Bpa, Danish Ansari Brt May 2026

Stereotactic Radiosurgery For Unruptured Arteriovenous Malformation Of The Left Medial Temporal Lobe In A Young Female, Muhammed Suhail S, Gajalakshmi M Bpa, Danish Ansari Brt

Journal Of Indian Physician Associates

Background

Arteriovenous malformations (AVMs) are congenital vascular anomalies that can be present with seizures or hemorrhage. Management strategies vary based on Spetzler-Martin (SM) grading.

Case Presentation

I report a case of a 22-year-old female presenting with recurrent seizures due to an unruptured AVM (SM Grade 3) located in the left medial temporal lobe. Diagnosis was established using MRI and Digital Subtraction Angiography (DSA).

Intervention

The patient underwent single-fraction stereotactic radio-surgery (SRS) with curative intent using a TrueBeam linear accelerator.

Outcome

Post-treatment course was uneventful, and the patient was discharged in stable condition with excellent seizure control and progressive nidus reduction …


Endo-Epicardial Ventricular Tachycardia Ablation In Arrhythmogenic Right Ventricular Cardiomyopathy- A Case Report, Selva Maheswari M Dr, Sharon Jabamalar Dr, Usnish Adhikari Dr, Deep Chandh Raja S Dr May 2026

Endo-Epicardial Ventricular Tachycardia Ablation In Arrhythmogenic Right Ventricular Cardiomyopathy- A Case Report, Selva Maheswari M Dr, Sharon Jabamalar Dr, Usnish Adhikari Dr, Deep Chandh Raja S Dr

Journal Of Indian Physician Associates

ABSTRACT:

Background

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare genetic disorder marked by progressive fibrofatty replacement of the right ventricle, causing life-threatening ventricular arrhythmias and sudden cardiac death (SCD). It is predominantly seen in young adults. As the substrate often involves both RV endocardium & epicardium, conventional ablation is often not successful. One of the effective therapies is combined endo- epicardial ablation, which gives good arrhythmia control and reduction of AICD (Automated Implantable Cardioverter Defibrillator) shock. Here we present two such cases.

Methods

Two patients presented with history of recurrent ventricular tachycardia (VT) which were reverted with DC (Direct …


From Confidence To Competence: Embedding Critical Genai Literacy In Physician Associate Education, Chanceeth Chandrakanthan, Amy H. Donaldson-Perrott Mrs, Jane Secker, Julie Voce, Tamara S. Ritsema May 2026

From Confidence To Competence: Embedding Critical Genai Literacy In Physician Associate Education, Chanceeth Chandrakanthan, Amy H. Donaldson-Perrott Mrs, Jane Secker, Julie Voce, Tamara S. Ritsema

Journal Of Indian Physician Associates

Background: Generative artificial intelligence is now embedded in how many healthcare students learn. Tools provide rapid explanations, summaries and practice questions, but use does not equal AI literacy, particularly where accuracy, medicines safety and guideline alignment matter.

Objective: To describe current use of generative AI by Physician Associate students and outline a practical approach to teaching critical AI literacy.

Methods: Educational evaluation using three activities: (1) baseline survey of students about use and attitudes, (2) an embedded compare and critique session in applied pharmacology where small groups assessed AI answers against trusted UK sources, including BNF and NICE guidance, followed …


Evaluating The Suitability Of The Berg Balance Scale For Assessing Balance In Diabetes With And Without Prior Covid-19: A Methods-Validation Study, Garima Kaushik Dr, Sheetal Malhan Dr., Apoorva Tiwari Dr, Vishakha Daga Dr May 2026

Evaluating The Suitability Of The Berg Balance Scale For Assessing Balance In Diabetes With And Without Prior Covid-19: A Methods-Validation Study, Garima Kaushik Dr, Sheetal Malhan Dr., Apoorva Tiwari Dr, Vishakha Daga Dr

Journal Of Indian Physician Associates

ABSTRACT

Background: Balance impairment in diabetes mellitus is predominantly driven by somatosensory loss secondary to peripheral neuropathy. The Berg Balance Scale (BBS) is widely used to evaluate functional balance, yet it mainly reflects motor performance and may not adequately represent sensory mechanisms. Following COVID-19, additional concerns regarding deconditioning have emerged, but interpretation depends on the measurement tool employed.

Objective: To examine the construct behavior and suitability of the BBS for assessing balance in individuals with diabetes with and without prior COVID-19 infection, and to determine whether the scale reflects known determinants of diabetic imbalance.

Methods: A cross-sectional analysis was conducted …


Exploring Identity Through Clay: A Humanistic Art Therapy Case Study With A Blind Chinese Adoptee, Virginia Jade Leicht May 2026

Exploring Identity Through Clay: A Humanistic Art Therapy Case Study With A Blind Chinese Adoptee, Virginia Jade Leicht

Expressive Therapies Theses

This qualitative case study explored how working with clay in art therapy can help support a blind man’s identity exploration. This paper addresses the problem of many traditional therapeutic approaches within the art therapy realm: They rely too heavily on visual engagement, which can limit the accessibility and opportunities for self-exploration and identity development for those who are blind. The study was grounded in current research and foundational theories based on the humanistic art therapy approach. Clay is considered an accessible medium that engages multiple senses and allows for emotional exploration and meaning making, specifically through tactile and sensory-based engagement …


Reimagining Occupational Therapy Fieldwork Mentorship Through A Cultural Wealth Lens: A World Café Study, Nandita A. Singh, Mph, Otr/L May 2026

Reimagining Occupational Therapy Fieldwork Mentorship Through A Cultural Wealth Lens: A World Café Study, Nandita A. Singh, Mph, Otr/L

Post-Professional Occupational Therapy Doctorate Culminating Presentations

Introduction: Occupational therapy (OT) fieldwork education plays a critical role in professional socialization; however, supervision models often privilege dominant sociocultural norms, disadvantaging students from non-dominant cultural and linguistic backgrounds and potentially limiting equitable workforce preparation.

Objectives: To examine how OT fieldwork partners conceptualize reciprocal mentorship within fieldwork education identify strategies grounded in Community Cultural Wealth (CCW) to support inclusive communication and strengths-based professional development.

Methods: Participatory qualitative study using a virtual World Café methodology, involving United States-based academic and clinical OT fieldwork contexts. Data were collected through audio-recorded discussions, digital whiteboards, and reflexive memos, and were analyzed using Braun …


How Do Autobiographical Memory Abilities Compare With Other Cognitive Functions In An Adult Presenting With Hsam (Highly Superior Autobiographical Memory) And Autism? A Case Study., Emilia Rzeszutek, Dr. Jamie Mayer May 2026

How Do Autobiographical Memory Abilities Compare With Other Cognitive Functions In An Adult Presenting With Hsam (Highly Superior Autobiographical Memory) And Autism? A Case Study., Emilia Rzeszutek, Dr. Jamie Mayer

Honors Capstones

Autism Spectrum Disorder (ASD) is a condition widely researched in relation to social communication differences and challenges in areas such as memory and executive functioning. Many areas of research highlight ASD’s deficits, shortcomings, and risk factors. However, research has begun to recognize that autistic individuals demonstrate cognitive strengths that differ from typical patterns of functioning. An example of such ability is Highly Superior Autobiographical Memory (HSAM), a rare phenomenon characterized by the ability to recall specific life events with remarkable accuracy and detail. This study was conducted on a 25-year-old male diagnosed with ASD and presents with characteristics of HSAM. …


Developing Engagement Programming To Increase Leisure Participation Among Individuals Living With Cognitive Impairments, Anthony Valentino, Bethany Horne Otd, Ms, Otr/L May 2026

Developing Engagement Programming To Increase Leisure Participation Among Individuals Living With Cognitive Impairments, Anthony Valentino, Bethany Horne Otd, Ms, Otr/L

Occupational Therapy Doctorate Capstones

Low-cost leisure activities are implemented at The Bridge Center to increase engagement and promote health and well-being. This program incorporates occupational therapy perspectives to promote engagement through meaningful activities to expand people with cognitive impairments opportunities. The results of this project will provide intrinsic benefits to people with cognitive impairments and aid the development of future projects at The Bridge Center.


The Efficacy Of An Educational Program On The Benefits Of Aquatic Therapy: An Occupational Therapy Perspective, Matile Kaplan, Kathryn Burke Otd, Otr/L May 2026

The Efficacy Of An Educational Program On The Benefits Of Aquatic Therapy: An Occupational Therapy Perspective, Matile Kaplan, Kathryn Burke Otd, Otr/L

Occupational Therapy Doctorate Capstones

Aquatic therapy has been a therapeutic modality since 2400 B.C and offers multisystem physiological effects including cardiovascular, musculoskeletal, immune, gastrointestinal, and more. The aquatic environment offers buoyancy, hydrostatic pressure, resistance, and drag force to ease engagement and recovery. Individuals have a higher rate of participation in aquatic therapy compared to on-land therapy, although referral rates are low due to the existing perceptions and insufficient awareness of the benefits.


Educating Birthing Professionals About The Benefits Of Occupational And Physical Therapy In The Acute Postpartum Period, Jayde Monteiro, Kathryn Burke Otd, Otr/L May 2026

Educating Birthing Professionals About The Benefits Of Occupational And Physical Therapy In The Acute Postpartum Period, Jayde Monteiro, Kathryn Burke Otd, Otr/L

Occupational Therapy Doctorate Capstones

Purpose: Across all developed countries, the US has the highest maternal mortality rate. The acute postpartum period is considered the first 6 weeks after birth and is often the most prevalent time medical complications arise. Currently there is a trend of OT and PT referral after these complications have already happened negatively impacted patients. To bring awareness and relevance to acute postpartum OT and PT, birthing professionals need more education to gain knowledge on how therapy can produce successful recovery outcomes in their patients. The research question "How does online educational programming increase birthing professionals’ knowledge about the benefits of …


Choosing Your Line: Training Adaptive Ski Instructors How To Facilitate Occupational Participation For Individuals With Complex Communication Needs., Jordan E. Chizmadia, Monique Dawes Otd, Otr/L Cpam May 2026

Choosing Your Line: Training Adaptive Ski Instructors How To Facilitate Occupational Participation For Individuals With Complex Communication Needs., Jordan E. Chizmadia, Monique Dawes Otd, Otr/L Cpam

Occupational Therapy Doctorate Capstones

The project will explore communication methods for individuals with complex communication needs (CCN) in adaptive skiing, focusing on alternative communication methods and the development of a Picture Exchange Communication System. A communication training program for ski instructors will be implemented. Findings will advance occupational therapy by highlighting the role of self-directed communication and autonomy in promoting occupational engagement for individuals with CCN.


Advancing Social-Emotional Wellness In Adolescents Through Structured Physical Fitness Programming, Serena Mora, Tania Rose Otd, Otr/L, Amy Wheadon Otd, Otr/L May 2026

Advancing Social-Emotional Wellness In Adolescents Through Structured Physical Fitness Programming, Serena Mora, Tania Rose Otd, Otr/L, Amy Wheadon Otd, Otr/L

Occupational Therapy Doctorate Capstones

Neurodivergent (ND) adolescents tend to struggle with participating in physical activity (PA) compared to their neurotypical (NT) peers. Current programs available that focus on PA are competitive and can add anxiety to an already difficult adjustment. This doctoral capstone project investigates the effect of participation in PA on social emotional well-being in ND adolescents. An 8-week PA program was created and implemented in this pre-post test quasi-experimental study.


Investigating The Sensory Needs Of Bereaved Children In A Therapeutic Group Setting, Eleanor Gemma, Bethany Horne Otd, Ms, Otr/L May 2026

Investigating The Sensory Needs Of Bereaved Children In A Therapeutic Group Setting, Eleanor Gemma, Bethany Horne Otd, Ms, Otr/L

Occupational Therapy Doctorate Capstones

Childhood bereavement is experienced by one in eleven children by age eighteen and is associated with a range of symptoms that impact function (Judi’s House, 2024; Stikkelbroek et al., 2016). Bereaved children often show increased internalizing symptoms for more than two years following loss and demonstrate challenges with self-regulation, which can impact a child’s participation in their everyday environments (Edgar-Bailey & Kress, 2010; Stikkelbroek et al., 2016). While dysregulation has been researched in children exposed to other forms of trauma, it and the resulting sensory needs of bereaved children are largely unexplored. This occupational therapy capstone project utilized mixed methods …


Effectiveness Of Occupation-Based Mindfulness Strategies For Older Adults Experiencing Anxiety Or Depression, Jennifer G. Macnie, Kathryn Burke Otd, Otr/L May 2026

Effectiveness Of Occupation-Based Mindfulness Strategies For Older Adults Experiencing Anxiety Or Depression, Jennifer G. Macnie, Kathryn Burke Otd, Otr/L

Occupational Therapy Doctorate Capstones

The purpose of this capstone is to gain an understanding of how sensory-based mindfulness strategies impact feelings of anxiety and depression amongst older adults living in an assisted living facility. Anxiety and depression are extremely prevalent among residents in assisted living facilities, with depression affecting 29% of older adults and anxiety affecting 20%. In light of the fact that mental health amongst older adults is often overlooked in assisted living facilities, it is necessary to evaluate the potential benefits of mindfulness strategies on feelings of anxiety and depression amongst this population. An investigation of how sensory based mindfulness strategies impact …


Advancing Neurodiverse-Affirming Care: Educating Caregivers To Improve Knowledge And Confidence​, Olivia Miller, Bethany Horne Otd, Ms, Otr/L May 2026

Advancing Neurodiverse-Affirming Care: Educating Caregivers To Improve Knowledge And Confidence​, Olivia Miller, Bethany Horne Otd, Ms, Otr/L

Occupational Therapy Doctorate Capstones

This capstone project aimed to implement a six-week education course on neurodiverse-affirming care to caregivers of neurodiverse children at Extraordinary Kids Therapy outpatient clinic in Chepachet RI. The goal of this capstone project was to increase confidence and knowledge of neurodiverse-affirming care in the caregivers participating in the course. To analyze the impact of the education course, pre and post surveys, along with semi-structured asynchronous zoom interviews were administered and analyzed.


Building Adolescents' Social Emotional Wellness Through Physical Fitness Programming, Serena Mora, Tania Rosa Otd, Otr/L May 2026

Building Adolescents' Social Emotional Wellness Through Physical Fitness Programming, Serena Mora, Tania Rosa Otd, Otr/L

Occupational Therapy Doctorate Capstones

Neurodivergent (ND) adolescents tend to struggle with participating in physical activity (PA) compared to their neurotypical (NT) peers. Current programs available that focus on PA are competitive and can add anxiety to an already difficult adjustment. This scoping review investigates the effect of participation in PA on behaviors and well-being connected to ND conditions.


A Multifaceted Approach To Managing Agitation In Assisted Living Residents With Dementia ​, Emily Hamed May 2026

A Multifaceted Approach To Managing Agitation In Assisted Living Residents With Dementia ​, Emily Hamed

Occupational Therapy Doctorate Capstones

Purpose: Dementia is a growing concern and will continue to increase. One symptom of dementia is agitation, which can be disruptive in an assisted living facility (ALF) and can impact quality of life for residents and caregivers/staff. Evidence shows that creating a conducive environment and equipping staff with skills can lead to better resident outcomes (Wong et al., 2024). This capstone project aims to address agitation by implementing physical and social environmental modifications in an (ALF). Design: This quasi-experimental mixed methods design will be conducted in an ALF to measure resident agitation pre and post intervention and staff confidence in …


“Empowering Peer Mentorship” Developing Best Practices Of Peer Mentoring At Empowersci Inc., Caitlyn Menard, Monique Dawes Otd, Otr/L Cpam May 2026

“Empowering Peer Mentorship” Developing Best Practices Of Peer Mentoring At Empowersci Inc., Caitlyn Menard, Monique Dawes Otd, Otr/L Cpam

Occupational Therapy Doctorate Capstones

Each Year, 250,000-500,000 people sustain a spinal cord injury (SCI) , facing challenges in social participation, quality of life, activities of daily living (ADLs), returning to work, and unmet needs in mental health, self-efficacy, and community mobility (Beauchamp et al., 2016 & Divanoglou et al., 2017). While interdisciplinary rehabilitation and peer mentorship aim to support adaptation, growth, and independence, there remains a lack of standardization in adequately preparing individuals for the peer mentor role (Rocchi et al., 2022). Aim: EmpowerSCI is a nonprofit organization that aims to bridge the gap in rehabilitation by offering in-person, holistic residential programming. EmpowerSCI currently …


Teacher Perceptions Of The Impact Of Sensory Integration And Processing On Student Occupational Engagement, Kyla Campbell, Colleen Cameron Whiting May 2026

Teacher Perceptions Of The Impact Of Sensory Integration And Processing On Student Occupational Engagement, Kyla Campbell, Colleen Cameron Whiting

Occupational Therapy Doctorate Capstones

Sensory Integration (SI) is defined as the brain's ability to organize and respond to information within the body and environment. School-aged children begin school with varying difficulties in SI and processing, which affects their social and academic performances. The field of occupational therapy (OT) promotes engagement in meaningful activities, in which going to school and participating in activities is vital to a child's development and wellbeing. The school setting is the second-largest employer of occupational therapy practitioners (OTPs) in the United States. Children with SI and processing difficulties have decreased participation in the classroom compared to their peers with typical …


Understanding Occupational Therapy Referral Patterns And Knowledge Gaps Among United States Medical Providers, Zachery Edwards, Shannon Strate Otd, Ms Otr/L May 2026

Understanding Occupational Therapy Referral Patterns And Knowledge Gaps Among United States Medical Providers, Zachery Edwards, Shannon Strate Otd, Ms Otr/L

Occupational Therapy Doctorate Capstones

Medical providers in the United States (US) have limited education and understanding of occupational therapy’s (OTs) full scope of practice (SOP), contributing to reduced access to OT services and potential negative consequences for client outcomes, interprofessional collaboration, and the profession’s viability (Rouch et al., 2022; Vij, 2023). This study aimed to examine US medical providers perspectives on OT utilization and identify areas of desired knowledge. Qualitative data was attained via a national survey administered to medical providers with analysis focused on responses to question three (Q3): “Why don't you refer clients to OT?” (n=424) and question six (Q6): “If you …


Utilization And Impacts Of Pediatric Caregiver Programming On Therapeutic Engagement And Wellbeing: A Pilot Program, Venisa Rodriguez, Tania Rose Otd, Otr/L May 2026

Utilization And Impacts Of Pediatric Caregiver Programming On Therapeutic Engagement And Wellbeing: A Pilot Program, Venisa Rodriguez, Tania Rose Otd, Otr/L

Occupational Therapy Doctorate Capstones

Purpose: The proposed doctoral capstone aims to measure the utilization and impacts of pediatric caregiver programming on therapeutic engagement and wellbeing. A scoping literature review and needs assessment of pediatric caregivers of children receiving OT services found that limited access to quality, caregiver-specific resources and programming impact the wellbeing of caregivers, their ability to care for their child, and their confidence and ability to engage in the therapeutic process. The literature points to a want and need for caregiver-specific programming and the use of a family-centered care approach to improve caregiver and child outcomes.

Design: This study will utilize a …


Development Of A Unique Surgical Implant To Address The Development Of Iatrogenic Trigeminal Neuralgia Following Maxillomandibular Advancement Surgery For Osa, Erika L. Manning, Kun Yoon, Robert Diecidue, Joseph Harrington May 2026

Development Of A Unique Surgical Implant To Address The Development Of Iatrogenic Trigeminal Neuralgia Following Maxillomandibular Advancement Surgery For Osa, Erika L. Manning, Kun Yoon, Robert Diecidue, Joseph Harrington

Department of Oral and Maxillofacial Surgery Faculty Papers

A 58 y/o male with no significant past medical history presented in 2021 with obstructive sleep apnea (OSA), including trouble breathing through his nose due to hypoplastic maxilla, retrognathic mandible and chin, and microgenia. He underwent a LeFort 1 maxillary osteotomy, bilateral sagittal split osteotomy (BSSO), and genioplasty with fat graft on 2/10/2022. Postoperatively, the patient developed moderate pain and facial edema, which progressed into hypoesthesia with pain in the face with a sensation of fullness in the left ear and left masseter tightness. He also developed a positive Tinel sign in the left mandibular area and was diagnosed with …


Evaluating The Impact Of A Meaningful Recognition Bundle On The Health Of The Emergency Department Work Environment And Emergency Nurse Burnout, Sean Truesdell May 2026

Evaluating The Impact Of A Meaningful Recognition Bundle On The Health Of The Emergency Department Work Environment And Emergency Nurse Burnout, Sean Truesdell

Doctoral Projects

Background: The health of the work environment significantly influences emergency nurse practice. The Emergency Nurses Association and the American Association of Critical-Care Nurses have called for the establishment of a healthy work environment (HWE) to improve outcomes, reduce burnout and turnover, and increase job satisfaction. Meaningful recognition is consistently among the lowest-performing HWE standards. Purpose: To implement a bundle of meaningful recognition elements in the Emergency Department (ED) and evaluate the outcomes. Methods: A quality improvement project was conducted in the ED of a non-profit community health system in Northern California. The Healthy Work Environment Assessment Tool (HWEAT) and Oldenburg …


Advancing Equitable Nurse Assignments Through Nursing Workload Score Categorization In An Adaptable Acuity Unit At An Academic Health Center, Moses Albaniel May 2026

Advancing Equitable Nurse Assignments Through Nursing Workload Score Categorization In An Adaptable Acuity Unit At An Academic Health Center, Moses Albaniel

Doctoral Projects

Inpatient nursing shift assignments often rely on clinical judgment, which can lead to inequitable workload distribution on mixed‑acuity units. This quality improvement project evaluated assignment equity using the coefficient of variation (CV) of nursing workload acuity scores and examined the relationship between workload balance and perceived assignment burden. A single‑group pretest–posttest design was implemented on a cardiac adaptable acuity unit at Stanford Health Care over a 12‑week period, encompassing 168 shifts from December 14, 2025, to March 7, 2026. The intervention, implemented with 11 charge nurses, combined structured charge nurse education with an optimized Epic Reporting Workbench tool incorporating dynamic …


Metabolic Dysfunction And Metabolic Management In Episodic Migraine, Delora E. Denney, Michael J. Marmura May 2026

Metabolic Dysfunction And Metabolic Management In Episodic Migraine, Delora E. Denney, Michael J. Marmura

Department of Jefferson Headache Center Papers and Presentations

PURPOSE OF REVIEW: Evidence suggests a significant link between migraine and metabolic syndrome,, especially in those with chronic or refractory migraine. Weight loss and exercise may effectively prevent migraine. Here, we review the evidence behind exercise and weight loss as migraine treatments.

RECENT FINDINGS: While metabolic syndrome and pain have long had a known association, only recently have strong studies demonstrated a higher risk of developing metabolic syndrome in people with migraine. Additionally, other sequelae of metabolic syndrome, obesity, hypertension, hypercoagulability, and diabetes also interplay with migraine. New medications like GLP-1 agonists may be a potential treatment for migraine as …


Antibody-Drug Conjugates Beyond Her2 In Non-Small Cell Lung Cancer (Nsclc): Mechanisms, Emerging Targets, And Future Directions., Ahmed Ismail, Aakash Desai, George R Simon, Yanis Boumber May 2026

Antibody-Drug Conjugates Beyond Her2 In Non-Small Cell Lung Cancer (Nsclc): Mechanisms, Emerging Targets, And Future Directions., Ahmed Ismail, Aakash Desai, George R Simon, Yanis Boumber

Oncology Articles

Antibody-drug conjugates (ADCs) are a rapidly evolving class of oncology therapeutics that enable precise delivery of potent cytotoxic agents to tumor cells while minimizing systemic toxicity. While HER2-targeted ADCs such as trastuzumab deruxtecan (T-DXd) in HER2-mutant, Datopotamab deruxtecan (Dato-Dxd) in EGFR-mutant, and telisotumumab vedotin (Teliso-V) in MET IHC 3+ expressing lung cancer have already established a clinical role in non-small cell lung cancer (NSCLC), multiple ADCs targeting alternative antigens, including additional TROP2 ADCs, HER3, MET, CEACAM5, B7-H3, Nectin-4, and others, are now in advanced clinical development. This review synthesizes the current evidence for non-HER2 ADCs in NSCLC, highlighting mechanisms of …


Experiences Of Discrimination, Paternal Support, And Hypertensive Disorders Of Pregnancy (Hdp) In The Miehr Study, Houston, Texas, Tahereh Alinia, Elaine Symanski, Juan Manuel Alvarez, Kristina Walker Whitworth May 2026

Experiences Of Discrimination, Paternal Support, And Hypertensive Disorders Of Pregnancy (Hdp) In The Miehr Study, Houston, Texas, Tahereh Alinia, Elaine Symanski, Juan Manuel Alvarez, Kristina Walker Whitworth

Faculty, Staff and Students Publications

Background: Discrimination is a psychosocial stressor that, through activation of stress-response pathways, may influence risk of adverse perinatal health outcomes. However, few studies have evaluated the association between discrimination and hypertensive disorders of pregnancy (HDP), and none have explored effect modification by race or paternal support, which may buffer the adverse effects of discrimination.

Methods: We included 1,847 non-Hispanic Black and White participants from the Maternal and Infant Environmental Health Riskscape (MIEHR) study. Krieger's validated Experiences of Discrimination (EOD) scale was used to assess occurrence (yes/no) and frequency (once, 2-3, ≥ 4 times) of discrimination in nine situations. We created …


Personalized Treatment Of Chronic Tendinopathy Using Ultrasound And Neuroimmune Markers: A Narrative Review, Rohan Phadke, Samer Salman, Kirtan Patel, Jad Wardeh, Akhil Marupudi, Rahul Kumar, Arbaz A. Momin, Alireza Tavakkoli May 2026

Personalized Treatment Of Chronic Tendinopathy Using Ultrasound And Neuroimmune Markers: A Narrative Review, Rohan Phadke, Samer Salman, Kirtan Patel, Jad Wardeh, Akhil Marupudi, Rahul Kumar, Arbaz A. Momin, Alireza Tavakkoli

Department of Neurosurgery Faculty Papers

Introduction: : Chronic tendinopathy affects approximately 30% of musculoskeletal consultations, yet treatment outcomes remain inconsistent despite numerous available interventions. This variability stems from the absence of validated frameworks to match individual patients to optimal treatments based on underlying pathophysiology. To synthesize current evidence on ultrasound imaging biomarkers, neuroimmune mechanisms, and interventional therapies in chronic tendinopathy, and propose a clinically applicable framework integrating ultrasound phenotyping with neuroimmune assessment to guide personalized treatment selection. Methods: A systematic literature search was conducted across PubMed, Scopus, and Web of Science through December 2025. Studies examining ultrasound/elastography imaging, neuroimmune mechanisms, or treatment interventions in chronic …


Morphological Assessment Of Stage Hh38 Of The Japanese Quail (Coturnix Japonica) Heart By Micro-Sonogram, Jaden Roe, Ashlyn Benavides, Michael B. Filla, Douglas C. Bittel, Whitney Shae, Geetha Haligheri, James E. O'Brien, Nataliya Kibiryeva May 2026

Morphological Assessment Of Stage Hh38 Of The Japanese Quail (Coturnix Japonica) Heart By Micro-Sonogram, Jaden Roe, Ashlyn Benavides, Michael B. Filla, Douglas C. Bittel, Whitney Shae, Geetha Haligheri, James E. O'Brien, Nataliya Kibiryeva

Manuscripts, Articles, Book Chapters and Other Papers

A challenge of studying mammalian cardiac embryogenesis is the limited ability to perform experimental manipulations in animal models. The avian embryo is widely accepted as a model for mammalian heart developmental studies. In this study, we establish the methodology and protocols for studying the Japanese quail (Coturnix japonica) heart at embryonic day 10 (HH38) using the FUJIFILM VisualSonics Vevo 3100 ultrasound system equipped with a MX550D small animal cardiology transducer. These protocols were designed to measure right ventricular wall thickness, pulmonary artery diameter, and the outflow velocities of the right ventricular outflow tract (RVOT) and the pulmonary artery …