Medicine and Health Sciences Commons^™

Machine Learning-Driven Prediction Of Severe Thrombocytopenia Risk In Crrt Patients, Michael Li, Divakar Sharma Md

Research Scholars

No abstract provided.

Macrophage Depletion Protects Against Cisplatin-Induced Ototoxicity And Nephrotoxicity, Cathy Yea Won Sung, Naoki Hayase, Peter S T Yuen, John Lee, Katharine Fernandez, Xuzhen Hu, Hui Cheng, Robert A Star, Mark E Warchol, Lisa L Cunningham

2020-Current year OA Pubs

Cisplatin is a widely used anticancer drug with notable side effects including ototoxicity and nephrotoxicity. Macrophages, the major resident immune cells in the cochlea and kidney, are important drivers of both inflammatory and tissue repair responses. To investigate the roles of macrophages in cisplatin-induced toxicities, we used PLX3397, a U.S. Food and Drug Administration-approved inhibitor of the colony-stimulating factor 1 receptor, to eliminate tissue-resident macrophages. Mice treated with cisplatin alone had considerable hearing loss (ototoxicity) and kidney injury (nephrotoxicity). Macrophage ablation resulted in significantly reduced hearing loss and had greater outer hair cell survival. Macrophage ablation also protected against cisplatin-induced …

Penetrating Posterior Urethral Injuries: Case Report And Management Strategies, Seyed Sajjad Tabei, Brandon Lippold, Wesley Baas, Gregory Murphy

2020-Current year OA Pubs

Penetrating posterior urethral trauma from gunshot wounds (GSW) is rare and requires prompt treatment to minimize complications. Data regarding the management of such cases is scarce in the literature and poorly addressed in the guidelines. Different management approaches exist, including urinary diversion with immediate versus delayed urethroplasty/fistula repair. We present our case series to add to our experience to the literature. Three patients aged 18-44 presented with ballistic posterior urethra injuries from GSW. Initial management involved urethral catheter placement, with one patient requiring operative placement of urethral and suprapubic catheters (SPTs). Complications included recurrent membranous stricture, urinary retention, rectourethral fistula, …

The Effect Of Vision Therapy In Post Concussion Recovery, Alexandra Kundek, Mark Cipolle Md, David Clark, Eden Hunt Md, Daniele Shollenberger Crnp

Research Scholars

No abstract provided.

Optimizing Diversity, Equity, And Inclusion (Dei) In Graduate Medical Education (Gme) At Lvhn, Paulina Royzman, Joseph E. Patruno Md, Robert Sweeny Mha

Research Scholars

No abstract provided.

Comparative Efficacy Of Transthoracic Vs. Transesophageal Echocardiogram In Diagnosing Endocarditis, Mackenzie Johnstone, Raul E Davaro Md

Research Scholars

No abstract provided.

Accuracy Of Rapid On-Site Cytology (Rose) For The Diagnosis Of Peripheral Lung Nodules During Robotic Bronchoscopy, Carly Mehta, Daniel Schwed-Lustgarten Md, Brian Civic Md

Research Scholars

No abstract provided.

Prevention Of Pressure Injuries Caused By Endotracheal Tube (Ett) Securement Devices, Grace M. Hercik, Kenneth Miller Med, Rrt-Nps, Daniel R Ofak Mha, Rrt-Nps

Research Scholars

No abstract provided.

Analyzing Patient Outcomes And Slp Perspectives To Prepare For The Onboarding Of Fees, Kaitlyn Shaffer, Kasey Hutter Ms, Ccc-Slp

Research Scholars

No abstract provided.

Performance Of A Biodegradable Temporary Matrix In Clinical Practice, Laetitia Roegner, Kurt Glaeser, Sigrid A. Blome-Eberwein Md

Research Scholars

No abstract provided.

Mitral Valve Surgery Outcomes For Severe Mitral Annular Calcification (Mac), Hoang Quach, Bryan D. Nelson Mba, Nr-P, James K. Wu Md

Research Scholars

No abstract provided.

Comparision Of Combination Test (Ct And Troponin) Against The Gold Standard Echocardiogram To Assess Right Ventricular Dysfunction In Acute Pulmonary Embolism, Nandini Venkiteswaran, Divakar Sharma Md

Research Scholars

No abstract provided.

Evaluating Influence Of Pharmaceutical Detailing On Osteoporosis Management In Outpatient Primary Care Settings, Sarah Davenport, Grant M. Greenberg M.D., M.H.S.A., M.A.

Research Scholars

No abstract provided.

Residency Redesign: Building Sustainable Family Medicine Residency Learning Networks (First Place), Athira Shastry, Drew Keister Md, Nyann Biery Dhsc, Karla J Felix Phd

Research Scholars

No abstract provided.

Powering Master Adaptive Learning: How Family Medicine Residents Embody A Growth Mindset, Prital Prabhu, Drew Keister Md, Karla J Felix Phd

Research Scholars

No abstract provided.

Exploring Contributors To Cervical Cancer Disparities In Hispanic Women Across Lehigh Valley Hot Spots: A Mixed Methods Analysis, Jocelyn Mertz, Roya Hamadani Mph, Nicole M. Burgess Bs, Melanie B. Johnson Mpa, Autumn Kieber-Emmons Md, Mph

Research Scholars

No abstract provided.

Firearm Injury Prevention Through Design And Delivery Of A Gun Lock Distribution, Afiya Bentinck, Melissa Mee Bsw

Research Scholars

No abstract provided.

Streamlining Split Flow: Evaluating Emergency Department Efficiency, Hope Boldizar, Rose Morgan, Cayden Rex, Kathleen E. Kane Md

Research Scholars

No abstract provided.

Mapping The Lived Experience: Access To Food And Green Spaces In Franklin Park, Allia Proctor, Cheryl Arndt Phd, Samantha A. Shaak Phd

Research Scholars

No abstract provided.

Evaluating The Validity Of Telehealth Nutrition Focused Physical Assessment For Malnutrition Diagnosis: A Comparative Study, Olivia Ahn, Melissa Faura Rd, Ldn, Ann Flickinger Ms, Rd, Ldn

Research Scholars

No abstract provided.

Analysis Of The Ed Pharmacy Process: From Medication Order To Administration, Hope Boldizar, Kathleen E. Kane Md, Beth Lally Pharmd

Research Scholars

No abstract provided.

Aso Author Reflections: The Association Between Sentinel Lymph Node Biopsy And Melanoma-Specific Survival In The Elderly, Luke D. Rothermel

Faculty Scholarship

No abstract provided.

In Silico Analysis Of The Rop29 Protein As A Vaccine Candidate Against Toxoplasma Gondii, Amir Karimipour-Saryazdi, Fatemeh Ghaffarifar, Abdolhossein Dalimi, Masoud Foroutan, John Horton, Javid Sadraei

Faculty, Staff and Student Publications

The progression of Toxoplasma gondii (T. gondii) invasion is aided by rhoptry proteins (ROPs), which are also crucial for the parasite's survival in host cells. In this study, in silico analysis was performed to examine the various aspects of the ROP29 protein, such as physicochemical properties, potential T- and B-cell epitopes, and other significant features. The research revealed that there were 55 possible sites for posttranslational modification in the ROP29 protein. The secondary structure of the ROP29 protein consists of a random coil, an alpha-helix, and an extended strand, which account for 49.69%, 36.81%, and 13.50%, respectively. Moreover, …

Detection Of Diffusely Abnormal White Matter In Multiple Sclerosis On Multiparametric Brain Mri Using Semi-Supervised Deep Learning, Benjamin C Musall, Refaat E Gabr, Yanyu Yang, Arash Kamali, John A Lincoln, Michael A Jacobs, Vi Ly, Xi Luo, Jerry S Wolinsky, Ponnada A Narayana, Khader M Hasan

Faculty, Staff and Student Publications

In addition to focal lesions, diffusely abnormal white matter (DAWM) is seen on brain MRI of multiple sclerosis (MS) patients and may represent early or distinct disease processes. The role of MRI-observed DAWM is understudied due to a lack of automated assessment methods. Supervised deep learning (DL) methods are highly capable in this domain, but require large sets of labeled data. To overcome this challenge, a DL-based network (DAWM-Net) was trained using semi-supervised learning on a limited set of labeled data for segmentation of DAWM, focal lesions, and normal-appearing brain tissues on multiparametric MRI. DAWM-Net segmentation performance was compared to …

The Impact Of The Covid-19 Pandemic On The Incidence Of Sexual Assaults And Victim Services, Jessica Hunter

Student Works

The Impact of the Covid-19 Pandemic on the Incidence of Sexual Assaults and Victim Services

Purpose: The purpose of this literature review is to discuss incidents/rates of sexual assaults (SA), access to or accessibility of SA victim services, and the utilization of SA services during the COVID-19 pandemic.

Background: In the U.S., 1 in 5 women experience rape or attempted rape, while 1 in 4 men experience some form of sexual violence in their lifetime. Additionally, SAs affect roughly one-third of the world's population, making SA a prominent problem worldwide.

Methods: Electronic searches in CINHAL and MEDLINE were performed using …

The Design And Impact Of Interactive Online Modules For Dental Faculty Calibration, Meixun Zheng, Debra Woo, Kim Benton

Pacific Faculty Work

The diverse backgrounds of health professions faculty often result in inconsistent teaching, clinical techniques, and feedback for students. Faculty calibration is essential for uniform, high-quality instruction. However, scheduling training sessions is challenging due to faculty availability. This study introduces a self-paced, interactive online approach to dental faculty calibration. Four self-paced online modules were developed using an interactive cloud-based platform. A variety of learning activities were interspersed throughout the module to promote active learning. A survey captured faculty’s perception of the online format. ANOVA analyses examined differences in perceived effectiveness of the online format between full-time, part-time, and adjunct faculty. The …

Impact Of Covid-19 On Dental Students’ Mental Health Status And Perception Of Sars-Cov-2 Vaccine, Man Hung, Nicole Hablitzel, Sharon Su, Samantha Melnitsky, Amir Mohajeri

Pacific Faculty Work

The COVID-19 pandemic disrupted dental education significantly, forcing adaptations in both didactic and clinical curricula. This study evaluates the impact of COVID-19 on dental students’ mental health and perceptions of the SARS-CoV-2 vaccine. An anonymous online survey was administered to dental students at Roseman University of Health Sciences, focusing on health experiences and vaccination perceptions. Results showed 56.8% of students were concerned about their emotional health, 82.1% felt stressed, and 60.6% felt depressed. About 81.9% received the vaccine, with 75.5% believing it effective, though only 55.3% supported mandatory vaccination. The pandemic negatively impacted students’ emotional health, indicating a need for …

Salivary Proteins In Human Acquired Enamel Pellicle (Aep) On Eroded And Uneroded Teeth In Patients With Gastro-Oesophageal Reflux Disease (Gord), Rasha Alharthi, Mahdi Mutahar, David Bartlett, Jafar Jafari, Rebecca Moazzez

Pacific Faculty Work

The aim of this in vivo study was to compare total protein present in the salivary films (F) and acquired enamel pellicle (AEP) on eroded and non-eroded surfaces in patients suffering from GORD symptoms with and without GORD diagnosis (GORD, No-GORD). Thirty-nine patients suffering from GORD symptoms and erosive tooth wear on lower first molars and an unaffected posterior occlusal surface in the same quadrant were recruited from Guy’s hospital, London. Salivary film and AEP were collected from the eroded and uneroded occlusal surfaces, using 0.5% sodium dodecyl sulphate (SDS)-soaked filter papers. Total protein concentration was analysed using bicinchoninic acid …

A Retrospective Quantitative Comparison Of Auto-Planning Vs. Manual-Planning For Large Breast Patients, Olivia R. Smiley

Masters Projects

Breast cancer is the most prevalent cancer among women in the United States, with many patients undergoing whole breast irradiation (WBI) following lumpectomy. Dosimetrists face challenges in planning WBI for patients with large breasts due to issues related to hotspots, dose uniformity, and extended planning times. Auto-planning tools like EZFluence, which use artificial intelligence, offer potential improvements in planning efficiency and dose distribution. This retrospective quantitative study compares auto-planning using EZFluence with manual planning for 10 large breast patients, aiming to reduce hotspots, achieve a more homogeneous dose, minimize doses to organs at risk (OARs), reduce monitor units (MUs), and …

Risk Factors Associated With Pyogenic Spinal Infections Among Intravenous Drug Users And Nonusers, Vivek Biololikar, Brendan Gleason, Lee Kripke, Robert Merrill, Colin Whitaker, Jon Handal

Einstein Health Papers

PURPOSE: To identify the differences in patient factors, presentation, treatment course, and outcomes of intravenous drug users (IVDA) vs. nonusers (non-IVDA) presenting with pyogenic spinal infections.

METHODS: We identified all cases involving spinal infections at our institution between May 2017 and January 2023. Postsurgical infections were excluded, and patients were separated into IVDA and non-IVDA groups. The patient charts were reviewed and analyzed for statistical or clinically significant differences using RStudio (2019 version 3.6.2). Our institutional review board approved this study, IRB# 2020-277, iRISID-2023-1384.

RESULTS: Fifty patients (29 males and 21 females) with primary pyogenic spinal infections were included in …