Medicine and Health Sciences Commons^™

Design Of Novel Inhibitors For Ischemia/Reperfusion Injury Targeting Ferroptosis, Xuyang Wang, Qiming Deng, Jingchen Hou, Kalyan Kumar Pasunooti, Kevin C. Bermea, Kai Li, Genaro Antonio Ramirez-Correa

School of Medicine Publications

No abstract provided.

Physical Activity Modifies The Risk Of Incident Cardiac Conduction Disorders Upon Inflammation: A Population-Based Cohort Study, Haiyan Zhao, Man Li, Dan Wu, Shuohua Chen, Chenrui Zhu, Yulong Lan, Hongmin Liu, Yuntao Wu, Shouling Wu

Research outputs 2022 to 2026

BACKGROUND: Emerging evidence suggests a central role for inflammation in cardiac conduction disorder (CCD). It is unknown whether habitual physical activity could modulate the inflammation-associated risks of incident CCD in the general population. METHODS AND RESULTS: This population-based cohort was derived from the China Kailuan study, including a total of 97 192 participants without prior CCD. The end points included incident CCD and its subcategories (atrioventricular block and bundlebranch block). Systemic inflammation was indicated by the monocyte-to-lymphocyte ratio (MLR). Over a median 10.91-year follow-up, 3747 cases of CCD occurred, with 1062 cases of atrioventricular block and 2697 cases of bundle-branch …

Microvascular Autologous Breast Reconstruction With The Lateral Thigh Perforator Flap, Stefania M.H. Tuinder, Joep A.F. Van Rooij, Robert J. Allen

School of Medicine Faculty Publications

The lateral thigh perforator flap is an excellent alternative to the deep inferior epigastric artery perforator (DIEP) flap for patients with absolute or relative contraindications for a DIEP flap and adequate volume at the lateral thigh. Preoperative physical examination, preoperative markings, and radiological perforator mapping are essential for adequate surgical preparation. The flap is based on septocutaneous perforators of the lateral circumflex femoral artery, located in the posterior septum between the tensor fascia latae and the gluteus medius muscle. Being relatively stiff, septocutaneous perforators are sensitive to kinking and compression, which is important to keep in mind during flap inset. …

The Complex Molecular Epileptogenesis Landscape Of Glioblastoma, Victoria Soeung, Ralph B Puchalski, Jeffrey L Noebels

Faculty, Staff and Students Publications

The cortical microenvironment surrounding malignant glioblastoma is a source of depolarizing crosstalk favoring hyperexcitability, tumor expansion, and immune evasion. Neosynaptogenesis, excess glutamate, and altered intrinsic membrane currents contribute to excitability dyshomeostasis, yet only half of the cases develop seizures, suggesting that tumor and host genomics, along with location, rather than mass effect, play a critical role. We analyzed the spatial contours and expression of 358 clinically validated human epilepsy genes in the human glioblastoma transcriptome compared to non-tumor adult and developing cortex datasets. Nearly half, including dosage-sensitive genes whose expression levels are securely linked to monogenic epilepsy, are strikingly enriched …

Junctophilin-2 Regulates Mitochondrial Metabolism, Sasha Z Prisco, Lynn M Hartweck, Felipe Kazmirczak, Jenna B Mendelson, Stephanie L Deng, Madelyn Blake, Satadru K Lahiri, Xander H T Wehrens, Kurt W Prins

Faculty, Staff and Students Publications

No abstract provided.

Epcam-Targeted Betulinic Acid Analogue Nanotherapy Improves Therapeutic Efficacy And Induces Anti-Tumorigenic Immune Response In Colorectal Cancer Tumor Microenvironment, Debasmita Dutta, Ashique Al Hoque, Brahamacharry Paul, Jun Hyoung Park, Chinmay Chowdhury, Mohiuddin Quadir, Soumyabrata Banerjee, Arghadip Choudhury, Soumik Laha, Nayim Sepay, Priyanka Boro, Benny Abraham Kaipparettu, Biswajit Mukherjee

Faculty, Staff and Students Publications

Background: Betulinic acid (BA) has been well investigated for its antiproliferative and mitochondrial pathway-mediated apoptosis-inducing effects on various cancers. However, its poor solubility and off-target activity have limited its utility in clinical trials. Additionally, the immune modulatory role of betulinic acid analogue in the tumor microenvironment (TME) is largely unknown. Here, we designed a potential nanotherapy for colorectal cancer (CRC) with a lead betulinic acid analogue, named as 2c, carrying a 1,2,3-triazole-moiety attached to BA through a linker, found more effective than BA for inhibiting CRC cell lines, and was chosen here for this investigation. Epithelial cell adhesion molecule (EpCAM) …

Impact Of Cyp1a2 Genotypes On The Ergogenic Effects And Subjective Mood States Of Caffeine Ingestion In Resistance-Trained Women, Jessica M Prather, Christine M Florez, Amie Vargas, Bella Soto, Audrey Ross, Abby Harrison, Ariane H Secrest, Darryn S Willoughby, Sydney Kutter, Lem W Taylor

Faculty, Staff and Students Publications

Caffeine’s metabolism is determined by CYP1A2 genotypes: AC/CC (SLOW) and AA (FAST). This trial evaluated CYP1A2 genotypes’ impact on exercise and cognitive effects in 36 resistance-trained females assessed under placebo (PL) and caffeine (6 mg/kg bw anhydrous caffeine-CAF) conditions, before ingestion and throughout the session. 23andMe® (San Francisco, CA, USA) determined genotypes using saliva. Data were analyzed using two-way RMANOVA and paired-samples t-tests (p < 0.05). A significant main effect for genotype existed for leg press repetitions to failure (RTF) for CAF (p = 0.038), with the FAST group performing more repetitions than the SLOW (p = 0.027). There was a significant condition x genotype interaction for the subjective outcome index score (p = …

Comprehensive Technical Analysis Of A Kickboxing Fight In K1 Format Based On Observation, Marta Niewczas, Wojciech Wąsacz, Wiesław Chwała, Tomasz Pałka, Ewa Sobiło-Rydzik, Tadeusz Ambroży, Kristína Němá, Łukasz Rydzik

Baltic Journal of Health and Physical Activity

Introduction: Observation and specialized analysis of confrontations in combat sports are fundamental for introducing corrections in training programs and for modifying the individual technical-tactical profiles of athletes in these types of activities. These actions comprehensively assess the progress of sports activities, ultimately inspiring and guiding the direction of training in sports clubs. The aim of this study was to analyze and assess the level of the offensive structure of Kickboxing sport fights in the K1 format, in terms of global simulated sparring, in selected thematic sets. Materials and Methods: The research material consisted of a multimedia recording of 10 simulated …

Interprofessional Collaboration As A Feminist Pedagogy: A Call For The Unsettling Of Care In Health Professions Education, Ivana Guarrasi, Rhonda Cornell, Sally Clemenson

Feminist Pedagogy

No abstract provided.

The Psychosocial Effect Of Video Games In A Hand Therapy Setting, Frank Arena, Rebecca King

Summer 2024 OTD Capstone Symposium

A project that analyzes the psychosocial effects of video games as an alternative to hand therapy interventions. This project addresses the barriers of financial investment, and space requirements. This project shows the effectiveness of video games as a short-term intervention method.

Adaptive Sports In Schools For Students With Disabilities From An Occupational Therapy Perspective, Tamara Harvey, Mary Jan Greer

Summer 2024 OTD Capstone Symposium

Children with disabilities do not have as many opportunities to participate in sports and leisure activities as their peers do, which may cause them to miss out on the benefits that participating in these activities offer. There are many barriers that children with disabilities and their parents face when seeking out adaptive sports activities especially in schools. This capstone project addressed some of these barriers. A needs assessment was conducted at an elementary school, which helped guide the development and implementation of the adaptive sports program, which is discussed in detail.

Addressing The Gap In Discharge Planning From A Skilled Nursing Facility, Yaqui Del Rio, Amy Lyons-Brown

Summer 2024 OTD Capstone Symposium

This project aims to improve health management in skilled nursing facilities (SNFs) by developing and implementing a comprehensive evaluation tool designed to assess patients' readiness for discharge. The tool addresses critical factors often overlooked during discharge planning, helping to identify areas where patients may feel unprepared or uncertain. By focusing on these areas, the project seeks to enhance patient outcomes and support effective health management.

Increasing Participation For Children With Special Needs, Calvin Shin, Amy Lyons-Brown

Summer 2024 OTD Capstone Symposium

This capstone project focuses on increasing participation for children with special needs through community engagement and social interactions. The purpose of this program is to explore the needs of children with special needs and increase participation of children within the community. The goal of this project is to increase participation in children with special needs, provide opportunities for children to feel more inclusive, promote meaningful relationships between peers, parents, and staff, and improve overall quality of life.

The Experience Of Pet Ownership In Transitional Housing, Kathryn Holden Ots, Susan Macdermott Otd, Otr/L

Summer 2024 OTD Capstone Symposium

25% of people experiencing homelessness have pets, but few transitional housing programs allow pets (Rhoades et al., 2015); therefore, there is a gap in the literature about the experience of pet ownership during the transitional housing process. This study aimed to explore pet owners' experiences at a transitional housing site in San Diego County. The student interviewed two current dog owners and four recent dog owners. All participants prioritized their pets because it was their strongest relationship. The prioritization of their dogs positively and negatively influenced occupational engagement. While receiving services, owners experienced consequences when separated from their dogs, including …

Ot’S Role In Facilitating Foster Youth's Transition To College And Career Exploration, Stacey Tang, Amy Lyons-Brown

Summer 2024 OTD Capstone Symposium

Foster youths often face numerous adversities, limiting their occupational performance and ability to transition into adulthood, specifically regarding career and education. This poster explores the role of Occupational Therapy (OT) in supporting these youths as they age out of foster care, particularly focusing on college and career exploration. Using the Person-Environment-Occupation-Performance (PEOP) and KAWA River models, a needs assessment was conducted in collaboration with Foster Love, a non-profit organization. The assessment revealed gaps in resources and support for foster youths, leading to the development of workshops that foster self-reflection, emotional regulation, and goal setting as they navigate their transition into …

The Effectiveness And Safety Of Stellate Ganglion Block In The Treatment Of Symptoms From Long Covid-19: A Pilot Study, Alexa O Levey, Grant H Chen, Alexandra Ngyuen, Luis Ostrosky-Zeichner, Jamal Hasoon, Sepideh Saroukhani, Matthew Lin

Faculty, Staff and Student Publications

Purpose: Pilot study to evaluate the safety and effectiveness of stellate ganglion blocks in the treatment of symptoms related to long COVID infection.

Materials and methods: A total of 17 patients who underwent stellate ganglion block for the treatment of their long COVID symptoms were included. COMPASS-31, GAD-7, PCL-5, and Fatigue Severity Score (FSS) pre and post intervention surveys and data on baseline heartrate and post- block heart rate recorded in the EMR.

Results: A total of 94% of patients reported moderate-to-severe autonomic dysfunction pre-procedure as measured by COMPASS-31. All patients reported some degree of symptomatic improvement from the block. …

Multiple Guidance Mechanisms Control Axon Growth To Generate Precise T-Shaped Bifurcation During Dorsal Funiculus Development In The Spinal Cord, Bridget M. Curran, Kelsey R. Nickerson, Andrea R. Yung, Lisa V. Goodrich, Alexander Jaworski, Marc Tessier-Lavigne, Le Ma

Farber Institute for Neuroscience Faculty Papers

The dorsal funiculus in the spinal cord relays somatosensory information to the brain. It is made of T-shaped bifurcation of dorsal root ganglion (DRG) sensory axons. Our previous study has shown that Slit signaling is required for proper guidance during bifurcation, but loss of Slit does not affect all DRG axons. Here, we examined the role of the extracellular molecule Netrin-1 (Ntn1). Using wholemount staining with tissue clearing, we showed that mice lacking Ntn1 had axons escaping from the dorsal funiculus at the time of bifurcation. Genetic labeling confirmed that these misprojecting axons come from DRG neurons. Single axon analysis …

Treating Mothers With Postpartum Depression While In The Nicu, Arrie Belnap, Mary Jan Greer, Aimee Doughty

Summer 2024 OTD Capstone Symposium

The presentation is about an educational program developed to educate mothers with or at risk for postpartum depression (PPD) while their baby is in the neonatal intensive care unit (NICU). Mothers learned about the nature of PPD, occupations to implement to decrease symptoms of PPD, and occupations that they can participate in to care for their NICU babies. The evaluations, interventions, and outcomes of the program are discussed.

Novel 3,6-Disubstituted Pyridazine Derivatives Targeting Jnk1 Pathway: Scaffold Hopping And Hybridization-Based Design, Synthesis, Molecular Modeling, In Vitro And In Vivo Anticancer Evaluation., Mai M. Shaalan, Essam Eldin A. Osman, Yasmeen M. Attia, Olfat A. Hammam, Riham F. George, Bassem H. Naguib

Pharmacy

A series of novel 3,6-disubstituted pyridazine derivatives was designed, synthesized, and biologically evaluated as preclinical anticancer candidates. Compound 9e exhibited the highest growth inhibition against most of the NCI-60 cancer cell lines. The in vivo anticancer activity of 9e was subsequently investigated at two dose levels using the Ehrlich ascites carcinoma solid tumor animal model where a reduction in the mean tumor volume allied with necrosis induction was reported, without any signs of toxicity in the treated groups. Interestingly, compound 9e was capable of downregulating c-jun N-terminal kinase-1 (JNK1) gene expression and curbing the protein levels of its phosphorylated form, …

08.19.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Lei Cao NSF award

FDP Meeting Summaries Available

August LINC Lunch

Collaboration Opportunities

Effects Of Dietary Nitrate Supplementation On High-Intensity Cycling Sprint Performance In Recreationally Active Adults: A Systematic Review And Meta-Analysis, Rachel Tan, Jordan K. Cass, Isabella G. Lincoln, Lauren E. Wideen, Madelyn J. Nicholl, Trevor J. Molnar, Lewis A. Gough, Stephen J. Bailey, Adam Pennell

All Faculty Open Access Publications

This systematic review and meta-analysis investigated the influence of dietary nitrate supplementation on performance metrics during cycling sprint exercise according to the PRISMA guidelines. Searches were conducted on MEDLINE, PubMed, ScienceDirect, Scopus, and SPORTDiscus databases up to September 2023. Inclusion criteria were healthy recreationally active men and women who consumed nitrate-rich and nitrate-deficient beetroot juice to assess performance outcomes of mean power, peak power, time-to-peak power, and minimum power during 30-s cycling sprints. Risk of bias was assessed using the Cochrane Risk of Bias 2 and TESTEX tools and funnel plots. A random effects model was performed on six studies …

Occupational Therapy’S Role In Addressing Wellness In Underserved Communities, Kimberlyna Chheang, Amy Lyons-Brown, Anna Saavedra

Summer 2024 OTD Capstone Symposium

This capstone project addresses sociodemographic disparities in community wellness and health services in Kern County, CA, focusing on underserved communities facing trauma and systemic inequalities. In collaboration with the Community Action Partnership of Kern (CAPK) and their East Kern Family Resource Center (EKFRC), it aims to lay the foundation for community-based, tailored interventions using occupational therapy (OT) to enhance community well-being and promote access to critical services to support wellbeing.

The Role Of Occupational Therapy With Neurodiversity-Inclusive Workplace Design​, Jasmine Hou, Susan Macdermott

Summer 2024 OTD Capstone Symposium

The purpose of this capstone project is to raise awareness and understanding of neurodiversity to foster neuroinclusive work environments. By addressing employment challenges faced by the neurodiverse community, occupational therapists can support neurodistinct adults who often lack accessible services to navigate the job cycle, promote opportunities for neurodistinct individuals to succeed in the workforce, and educate employers on neuroinclusive design.

Outdoor Recreation For People With Spinal Cord Injuries: An Educational Video Series, Siarra N. Walker, Steven M. Gerardi, Heather Rennerfeldt

Summer 2024 OTD Capstone Symposium

More than 15 million people globally are living with spinal cord injury (SCI). Only half of people with SCI engage in leisure activities and approximately 71% of the population reports dissatisfaction in their leisure participation. There are numerous intrinsic and extrinsic barriers that lead to these significant declines in leisure exploration and participation, including lack of knowledge and inaccurate accessible online information. In correlation with these barriers, occupational therapy practitioners underutilize leisure participation during the rehabilitation process for people with SCI and this is an underreported topic in the literature. Occupational therapy practitioners and people with SCI lack knowledge of …

Occupational Impact Of Urinary Incontinence, Hannah Case, Karen Park

Summer 2024 OTD Capstone Symposium

The purpose of this capstone project was to conduct a research study to identify if children with UI encountered occupational impacts due to their condition, as well as their caregivers. Twelve caregivers participated in an online survey investigating the occupational impact (supports, barriers, and limitations) of being a caregiver to a child who encounters UI. The survey addressed how their child’s UI affects various occupations. The findings indicate a significant impact on leisure participation and home management. The qualitative data was acquired through unobtrusive methods, including narratives, blogs, and lived experiences, to provide the perspective of how UI affects children. …

Consideration Of Language, Culture-Education, And Advocacy For Latino Families Who Use Therapy Services, Melina Rodriguez, Rachael Fox, Mary Greer

Summer 2024 OTD Capstone Symposium

Latino families of children with ASD face additional barriers within society compared to other families, including surrounding stigma within the culture, language barriers, lack of resources, and lack of education on how to access these resources. One of the focuses of occupational therapy is to provide education and advocacy to individuals and their families who face occupational barriers. This program was created to provide education to Latino families of children diagnosed with ASD through participation in weekly sessions that cover various topics related to ASD.

Addressing The Potential Impacts Of Mental Illness Symptoms On Daily Occupations For Adolescents, Ashley Manjai, Mary Greer, Terah Harrison

Summer 2024 OTD Capstone Symposium

This presentation discusses a program developed for adolescents to address mental illness symptoms and its impact on personal hygiene, academic performance, leisure, and social participation. The modules were developed under the title "Healthy Living" to take a more holistic approach to addressing mental health and the issues teenagers face daily. This presentation will provide an overview of the program's purpose, methods, and conclusion.

Home Health Program For Newly Hired Occupational Therapists, Benjamin Elliott, Rebecca King

Summer 2024 OTD Capstone Symposium

Occupational therapists working in the field of home health care are four times lower than other settings. The program was created for newly hired OTs outlining symptoms, assessments, precautions, and interventions relevant to common diagnoses seen in home health.

Exploration Of Club Motorcycle Riding For Veteans, Dakota Strahl, Amy Lyons-Brown

Summer 2024 OTD Capstone Symposium

There is significantly limited research regarding the occupation of club motorcycle riding, and even more limited with its application to the veteran population

The study yielded 17 survey participants and 7 interview participants from the VFW MC. The study aimed to discover the benefits of club motorcycle riding for the veteran population through a Doing, Being, Becoming, and Belonging Framework. The data consisted of both quantitative and qualitative components which revealed four overall themes.

The four main themes that came from the data analysis were (1) Camaraderie, (2) Mental and Emotional Health Through Occupation, (3) Reconstruction of Identity, and (4) …

Adapted Cheerleading Program For The Pediatric Population, Hailee Cantrell, Mary Greer, Jasmine Mathew

Summer 2024 OTD Capstone Symposium

There are limited adapted programs with educated professionals that exist for children with childhood disabilities to be able to adapt activities to the specific needs of the child. Due to the limited opportunities for participation in leisure activities, these children have limited opportunities to improve physical, verbal, or emotional skills with their peers. The objective of this capstone was to create an adapted cheerleading program for the pediatric population to improve their physical, emotional, and verbal abilities as well as improve their mental health and overall quality of life.