Medicine and Health Sciences Commons^™

Role Of Titanium-Reinforced Platelet-Rich Fibrin In Periodontal Tissue Regeneration-A Systematic Review, Bhavya Manchala, Anurag Teju, Mohan Kumar Pasupuleti, Gautami S Penmetsa, Sruthima Gottumukkala, Venkata Lakshmi

Journal of Dentistry Indonesia

Objective: The objective of the study is to demonstrate the efficacy of Titanium reinforced platelet-rich fibrin (T-PRF) as the sole biomaterial amongst the biologics in periodontal regeneration of both soft and hard tissues. Methods: A PUBMED database search is conducted from August 2013 to August 2023. Only original articles, including Randomized controlled clinical trials, cross-sectional studies, prospective studies, and case-control studies, were included. The studies will be analyzed regarding the outcome of the association between T-PRF and periodontal regeneration of both hard and soft tissue. Results: From 35 articles identified, 8 RCTs were included. The use of …

Avicennia Marina Mangrove Plant Mediated Selenium Nanoparticles And Their Therapeutic Activity Against Oral Pathogens And Other Biological Properties, Kannan Kamala, Pitchiah Sivaperumal, Dhanraj Ganapathy

Journal of Dentistry Indonesia

In the last few decades nanoparticles are widely used in the control of many pathogenic bacteria, fungi, viruses, and cancer growth both in-vitro and in-vivo. A marine plant of Avicennia marina is widely used in traditional medicine for diabetes, inflammation and skin diseases. Objective: In general Avicennia marina has been used as a traditional medicine to treat various diseases and it has shown significant inhibition against various pathogen and the formation of free radicals. Also, the plant A.marina mediated selenium nanoparticles has therapeutic activity has promising to develop biocompatible new cost effective treatment for various oral diseases. Methods: …

Remineralization Potential Of Grape Seed Extract On Artificial Enamel Caries Lesions, Serif Alpcan Ozden, Esra Oz

Journal of Dentistry Indonesia

Objective: This study aimed at a comparative analysis of the remineralization potential of grape seed extract (GSE) alone, together with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and/or acidulated phosphate fluoride (APF). Methods: The samples were randomly divided into seven groups according to the treatment used: 25% GSE, 1.23% APF (Gelato APF gel), and CPP-ACP (GC Tooth Mousse). The samples in group 7 received no treatment as a control group. All specimens were subjected to pH cycling for two weeks. Surface microhardness analyses were performed at baseline, after demineralization and remineralization. Data were analyzed using one-way analysis of variance (ANOVA), …

In Silico Modelling And Docking Simulation Of Egfr-Targeted Diphtheria Toxin Chimera With Various Targeting Moieties, Muhammad Afif Naufal Bmed, Benedictus Ansell Susanto Bmed, Talitha Dinda Gunawan Bmed, Azhar Ridha Lukman Bmed, Alifa Rahma Rizqina Bmed, Muhammad Misbahul Fuad Bmed

Indonesian Journal of Medical Chemistry and Bioinformatics

Introduction: Cancer is a major etiology of death worldwide due to high mortality and suboptimal medicine. However, an emerging field, targeted therapy enabled a more selective and effective therapeutic action. This article aims to analyze in-silico the hypothetical targeted therapy agent that is combinations of conjugate consisting of EGFR targeting moieties and diphtheria toxin (DT-390).

Method: Our novel peptide is a conjugate of a novel EGFR targeting peptide and DT-390, forming a chimera. The tertiary structure was predicted using AlphaFold 2.0. The best IDDT scoring and stereochemistry profiles were utilized. The HADDOCK2.4 webserver modelled the docking between our …

Unveiling Environmental Justice In Two Us Cities Through Greenspace Accessibility And Visible Greenness Exposure, Md Shahinoor Rahman, Mahbubur Meenar, S. M. Labib, Ted Howell, Deepti Adlakha, Ben Woodward

School of Public Health Faculty Publications

Uneven access to greenspaces or visible greenness is an environmental justice (EJ) issue. In this paper, we use a social equity lens to develop geospatial models that measure convenient walking access to urban greenspaces such as parks and street-level green exposure en route to greenspaces. We utilized earth science, geospatial, and demographic datasets to develop two models—Greenspace Accessibility and Visible Greenness Exposure—and applied them in Camden and Jersey City, USA, two communities experiencing environmental injustices. Modeling results show that greenspace accessibility is a concern in both cities, with Jersey City experiencing more prominent disparities. We observed significant positive relationships in …

Comprehensive Analysis Of Substernal Lead Removal: Experience From Ev Icd Pilot, Pivotal, And Continued Access Studies., Venkata Sagi, Francis Murgatroyd, Lucas V A Boersma, Jaimie Manlucu, Bradley P Knight, Christophe Leclercq, Anish Amin, Ulrika Maria Birgersdotter-Green, Joseph Yat Sun Chan, Henri Roukoz, Mauro Biffi, Haris Haqqani, Russell Denman, Christopher Wiggenhorn, Thomas R Holmes, Thomas Lulic, Paul Friedman, Ian Crozier

Heart and Vascular Articles

AIMS: The extravascular implantable cardioverter-defibrillator (EV ICD) has been shown to be safe and effective for patients at risk of sudden cardiac death, but little is known about EV ICD lead removal in humans. This analysis aimed to characterize the EV ICD lead removal experience thus far.

METHODS AND RESULTS: This was a retrospective analysis of lead removals from the EV ICD Pilot, Pivotal, and Continued Access Studies. Patients with a successful EV ICD implant who underwent lead removal were included. The main objective was lead removal success. Ancillary objectives included characterizing technique used, procedure complications, and reimplantation status. An …

Rasch Validation Of Arabic Scale Of Mental Health (Asmh) In Indonesian Version To Measure Adolescent Mental Health, Dody Hartanto, Mufied Fauziah, Yenni Rizal, Imam Azhari, Ratu Matahari, Parhan Fauzan, Nuri Cholidah Hanum, Diki Herdiansyah

Jurnal Kajian Bimbingan dan Konseling

Mental health is a crucial aspect for adolescents, as those with poor mental health may experience conditions ranging from depression and anxiety disorders to suicidal tendencies. Identifying mental health issues is essential, necessitating an instrument to assess adolescent mental health. This study aims to adapt the Arabic Scale of Mental Health (ASMH) into Indonesian and evaluate its validity using the Rasch model. The adaptation process followed the Procedures and Guidelines for Translating Counselling Assessment as outlined by Lenz, Gómez Soler, Dell'Aquilla, and Uribe. The translated instrument was administered to 685 high school and vocational school students from Yogyakarta. The instrument …

Relationship Between Academic Burnout And Academic Resilience Manifest In Prospective Counselors During The New Normal Era, Indriyana Rachmawati, Moh Farozin, Agus Basuki

Jurnal Kajian Bimbingan dan Konseling

Academic resilience has become an interesting topic of discussion as a result of the increase in academic burnout experienced by prospective counselors recently as a result of increasing academic assignments. Prospective counselors who experience academic burnout generally have poor academic resilience because they feel tired or bored with academic tasks while still studying, and this has an impact on the resulting performance. This research aims to determine the relationship between academic burnout and the academic resilience of prospective counselors. We used a quantitative research method, employing a correlation research design, to reveal the relationship between the two. The research sample …

Development Of Metaverse-Based Virtual Reality Counseling: Technology-Assisted Psychological Services For Students With Disabilities, Imam Ariffudin, Muhammad Nur Hudha, Akhmad Zaini, Ajeng Intan Nur Rahmawati

Jurnal Kajian Bimbingan dan Konseling

This study aims to develop a metaverse-based Virtual Reality Counseling (VRC) medium to support psychological services for students with special needs. The research method used is the research and development method with the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation). The results show that the metaverse-based VRC medium has met the media acceptability aspects, making it feasible for effective implementation. Additionally, experimental results indicate a decrease in the levels of mental health disorders experienced by the counselees after undergoing individual counseling assisted by the metaverse-based VRC medium. The impact of this study suggests that the metaverse-based VRC medium is …

Boosting Teacher Work Engagement: The Role Of Self-Efficacy, Resilience, And Personality Traits, Ajar Dirgantoro, Nur Eva, Fattah Hanurrawan, Imanuel Hitipeuw

Jurnal Kajian Bimbingan dan Konseling

The role of a teacher in the world of education greatly affects how the quality of students with the expected changes cannot be separated from the responsibility of a teacher in educating, guiding, motivating and being a facilitator for these students. However, low work involvement by teachers is not able to achieve organizational or school success in producing quality successors. The intended work engagement is a series of results from the teacher's self-efficacy and resilience towards himself and work tasks. This study aims to empirically examine the effect of self-efficacy and resilience on teacher work engagement with personality traits as …

Psychological Dynamics Among Adolescents With Self-Harm Behavior Based On Rational Emotive Behavior Therapy, Hengki Tri Hidayatullah, Arbin Janu Setiyowati, Irene Maya Simon, Riyani Indriyati, Maria Teresa Mattingly

Jurnal Kajian Bimbingan dan Konseling

The objective of this study was to ascertain the psychological underpinnings of self-harm behaviors among adolescents, with a particular emphasis on the tenets of rational emotive behavior therapy (REBT). Additionally, this study aimed to elucidate the various forms of self-harm behaviors and the underlying factors that contribute to these behaviors in adolescents. This research employed a qualitative approach with a phenomenological research design. The research subjects were students at State Senior High School 1 Batu, Indonesia, selected based on certain criteria in accordance with the research needs (purposive sampling). The results demonstrate three key aspects of the psychological dynamics of …

Stie: Single-Cell Level Deconvolution, Convolution, And Clustering In In Situ Capturing-Based Spatial Transcriptomics, Shijia Zhu, Naoto Kubota, Shidan Wang, Tao Wang, Guanghua Xiao, Yujin Hoshida

Faculty, Staff and Student Publications

In in situ capturing-based spatial transcriptomics, spots of the same size and printed at fixed locations cannot precisely capture the randomly-located single cells, therefore inherently failing to profile transcriptome at the single-cell level. To this end, we present STIE, an Expectation Maximization algorithm that aligns the spatial transcriptome to its matched histology image-based nuclear morphology and recovers missing cells from ~70% gap area, thereby achieving the real single-cell level and whole-slide scale deconvolution, convolution, and clustering for both low- and high-resolution spots. STIE characterizes cell-type-specific gene expression and demonstrates outperforming concordance with true cell-type-specific transcriptomic signatures than the other spot- …

Micronuclear Collapse From Oxidative Damage, Melody Di Bona, Yanyang Chen, Albert S Agustinus, Alice Mazzagatti, Mercedes A Duran, Matthew Deyell, Daniel Bronder, James Hickling, Christy Hong, Lorenzo Scipioni, Giulia Tedeschi, Sara Martin, Jun Li, Aušrinė Ruzgaitė, Nadeem Riaz, Parin Shah, Edridge K D'Souza, D Zack Brodtman, Simone Sidoli, Bill Diplas, Manisha Jalan, Nancy Y Lee, Alban Ordureau, Benjamin Izar, Ashley M Laughney, Simon Powell, Enrico Gratton, Stefano Santaguida, John Maciejowski, Peter Ly, Thomas M Jeitner, Samuel F Bakhoum

Faculty, Staff and Student Publications

Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear rupture catalyzes chromosomal rearrangements, epigenetic abnormalities, and inflammation, yet mechanisms safeguarding micronuclear integrity are poorly understood. In this study, we found that mitochondria-derived reactive oxygen species (ROS) disrupt micronuclei by promoting a noncanonical function of charged multivesicular body protein 7 (CHMP7), a scaffolding protein for the membrane repair complex known as endosomal sorting complex required for transport III (ESCRT-III). ROS retained CHMP7 in micronuclei while disrupting its interaction with other ESCRT-III components. ROS-induced cysteine oxidation stimulated CHMP7 oligomerization and …

Identification Of A0 Minimum Ablative Margins For Colorectal Liver Metastases: Multicentre, Retrospective Study Using Deformable Ct Registration And Artificial Intelligence-Based Autosegmentation, Iwan Paolucci, Jessica Albuquerque Marques Silva, Yuan-Mao Lin, Gregor Laimer, Valentina Cignini, Francesca Menchini, Marcio Meira, Alexander Shieh, Caleb O'Connor, Kyle A Jones, Carlo Gazzera, Paolo Fonio, Kristy K Brock, Marco Calandri, Marcos Menezes, Reto Bale, Bruno C Odisio

Faculty, Staff and Student Publications

Background: Several ablation confirmation software methods for minimum ablative margin assessment have recently been developed to improve local outcomes for patients undergoing thermal ablation of colorectal liver metastases. Previous assessments were limited to single institutions mostly at the place of development. The aim of this study was to validate the previously identified 5 mm minimum ablative margin (A0) using autosegmentation and biomechanical deformable image registration in a multi-institutional setting.

Methods: This was a multicentre, retrospective study including patients with colorectal liver metastases undergoing CT- or ultrasound-guided microwave or radiofrequency ablation during 2009-2022, reporting 3-year local disease progression (residual unablated tumour …

Inhibition Of Ulk1/2 And Kras G12c Controls Tumor Growth In Preclinical Models Of Lung Cancer, Phaedra C Ghazi, Kayla T O'Toole, Sanjana Srinivas Boggaram, Michael T Scherzer, Mark R Silvis, Yun Zhang, Madhumita Bogdan, Bryan D Smith, Guillermina Lozano, Daniel L Flynn, Eric L Snyder, Conan G Kinsey, Martin Mcmahon

Faculty, Staff and Student Publications

Mutational activation of KRAS occurs commonly in lung carcinogenesis and, with the recent U.S. Food and Drug Administration approval of covalent inhibitors of KRASG12C such as sotorasib or adagrasib, KRAS oncoproteins are important pharmacological targets in non-small cell lung cancer (NSCLC). However, not all KRASG12C-driven NSCLCs respond to these inhibitors, and the emergence of drug resistance in those patients who do respond can be rapid and pleiotropic. Hence, based on a backbone of covalent inhibition of KRASG12C, efforts are underway to develop effective combination therapies. Here, we report that the inhibition of KRASG12C signaling increases autophagy in KRASG12C-expressing lung cancer …

Successful Management Of Pre-Existing Psoriatic Arthritis Through Targeting The Il-23/Il-17 Axis In Cancer Patients Receiving Immune Checkpoint Inhibitor Therapy: A Case Series, Yuanteng Jeff Li, Pavlos Msaouel, Matthew Campbell, Patrick Hwu, Adi Diab, Sang T Kim

Faculty, Staff and Student Publications

BACKGROUND: Immune checkpoint inhibitors (ICIs) have significantly improved outcomes for patients with cancer. However, these therapies are associated with adverse events including de novo immune-related adverse events or flare of pre-exiting autoimmune disorders. Up to 80% of patients with cancer and pre-existing psoriasis (PsO) or psoriatic arthritis (PsA) experience PsO/PsA flare after initiating ICIs. Targeting the interleukin (IL)-17/IL-23 axis is a mainstream of the PsO/PsA treatment. However, whether this treatment can effectively control PsO/PsA with ICI exposure while preserving anti-tumour efficacy remains unknown.

CASE REPORTS: We report three patients with PsA and cancer, who received ICIs for their cancer treatment. …

Brief Report: Incidence And Outcomes Of Pediatric Tracheal Intubation-Associated Cardiac Arrests In The Icu-Resus Clinical Trial, Akira Nishisaki, Ron Reeder, Elizabeth Laverriere Mcgovern, Tageldin Ahmed, Michael Bell, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph Carcillo, Todd Carpenter, Wesley Diddle, Myke Federman, Ericka Fink, Deborah Franzon, Aisha Frazier, Stuart Friess, Kathryn Graham, Mark Hall, David Hehir, Christopher M Horvat, Leanna Huard, Tensing Maa, Arushi Manga, Patrick Mcquillen, Kathleen Meert, Ryan Morgan, Peter Mourani, Vinay Nadkarni, Maryam Naim, Daniel Notterman, Chella Palmer, Anil Sapru, Carleen Schneiter, Matthew Sharron, Neeraj Srivastava, Shirley Viteri, David Wessel, Heather Wolfe, Andrew Yates, Athena Zuppa, Robert Sutton, Robert Berg

Department of Pediatrics Faculty Papers

BACKGROUND: Tracheal intubation (TI)-associated cardiac arrest (TI-CA) occurs in 1.7% of pediatric ICU TIs. Our objective was to evaluate resuscitation characteristics and outcomes between cardiac arrest patients with and without TI-CA.

METHODS: Secondary analysis of cardiac arrest patients in both ICU-RESUS trial and ancillary CPR-NOVA study. The primary exposure was TI-CA, defined as cardiac arrest occurred during TI procedure or within 20 min after endotracheal tube placement. The primary outcome was survival to hospital discharge with favorable neurological outcome (Pediatric Cerebral Performance Category score 1-3 or unchanged).

RESULTS: Among 315 children with cardiac arrests, 48 (15.2%) met criteria for TI-CA. …

Barriers And Facilitators To Administering Burn Pit Registry Exams In Vha Facilities, Patricia V Chen, Israel C Christie, Kyler M Godwin, Jaehwan Han, Nisha Jani, Anays Sotolongo, Asma Ali, Drew A Helmer

Faculty and Staff Publications

Introduction: The Veterans Health Administration (VHA) established the Airborne Hazards and Open Burn Pit Registry (AHOBPR) in 2014 to address exposure concerns for veterans who have served in military operations in Southwest Asia and Afghanistan. By 2021, over 236,086 veterans completed the online questionnaire and 60% requested an AHOBPR examination. Of those requesting an exam, only 12% had an exam recorded in their medical record. This article summarizes barriers and facilitators to delivering AHOBPR exams and shares lessons learned from facilities who have successfully implemented burn pit exams for veterans.

Materials and methods: We (I.C.C and J.H.) constructed a key …

Persistent Mri Findings Unique To Blast And Repetitive Mild Tbi: Analysis Of The Cenc/Limbic Cohort Injury Characteristics, David F Tate, Benjamin S C Wade, Carmen S Velez, Erin D Bigler, Nicholas D Davenport, Emily L Dennis, Carrie Esopenko, Sidney R Hinds, Jacob Kean, Eamonn Kennedy, Kimbra Kenney, Andrew R Mayer, Mary R Newsome, Carissa L Philippi, Mary J Pugh, Randall S Scheibel, Brian A Taylor, Maya Troyanskaya, John K Werner, Gerald E York, William Walker, Elisabeth A Wilde

Faculty, Staff and Students Publications

Introduction: MRI represents one of the clinical tools at the forefront of research efforts aimed at identifying diagnostic and prognostic biomarkers following traumatic brain injury (TBI). Both volumetric and diffusion MRI findings in mild TBI (mTBI) are mixed, making the findings difficult to interpret. As such, additional research is needed to continue to elucidate the relationship between the clinical features of mTBI and quantitative MRI measurements.

Material and methods: Volumetric and diffusion imaging data in a sample of 976 veterans and service members from the Chronic Effects of Neurotrauma Consortium and now the Long-Term Impact of Military-Relevant Brain Injury Consortium …

Deployment-Related Cigarette Smoking Behaviors And Pulmonary Function Among Us Veterans, Jennifer R Maccarone, Olivia R Sterns, Andrew Timmons, Anna M Korpak, Nicholas L Smith, Karen S Nakayama, Coleen P Baird, Paul Ciminera, Farrah Kheradmand, Vincent S Fan, Jaime E Hart, Petros Koutrakis, Michael Jerrett, Ware G Kuschner, Octavian C Ioachimescu, Philippe R Montgrain, Susan P Proctor, Carrie A Redlich, Christine H Wendt, Paul D Blanc, Eric Garshick, Emily S Wan

Faculty, Staff and Students Publications

Introduction: The effects of smoking on lung function among post-9/11 Veterans deployed to environments with high levels of ambient particulate matter are incompletely understood.

Materials and methods: We analyzed interim data (04/2018-03/2020) from the Veterans Affairs (VA) Cooperative Studies Program #595, "Service and Health Among Deployed Veterans". Veterans with ≥1 land-based deployments enrolled at 1 of 6 regional Veterans Affairs sites completed questionnaires and spirometry. Multivariable linear regression models assessed associations between cigarette smoking (cumulative, deployment-related and non-deployment-related) with pulmonary function.

Results: Among 1,836 participants (mean age 40.7 ± 9.6, 88.6% male), 44.8% (n = 822) were ever-smokers (mean age …

Histone H3.3 Lysine 9 And 27 Control Repressive Chromatin At Cryptic Enhancers And Bivalent Promoters, Matteo Trovato, Daria Bunina, Umut Yildiz, Nadine Fernandez-Novel Marx, Michael Uckelmann, Vita Levina, Yekaterina Perez, Ana Janeva, Benjamin A Garcia, Chen Davidovich, Judith B Zaugg, Kyung-Min Noh

2020-Current year OA Pubs

Histone modifications are associated with distinct transcriptional states, but it is unclear whether they instruct gene expression. To investigate this, we mutate histone H3.3 K9 and K27 residues in mouse embryonic stem cells (mESCs). Here, we find that H3.3K9 is essential for controlling specific distal intergenic regions and for proper H3K27me3 deposition at promoters. The H3.3K9A mutation resulted in decreased H3K9me3 at regions encompassing endogenous retroviruses and induced a gain of H3K27ac and nascent transcription. These changes in the chromatin environment unleash cryptic enhancers, resulting in the activation of distinctive transcriptional programs and culminating in protein expression normally restricted to …

Association Between Growth Differentiation Factor-15 And Adverse Outcomes Among Patients With Heart Failure: A Systematic Literature Review, Ali Javaheri, Mualla Ozcan, Lauren Moubarak, Karen E Smoyer, Michelle I Rossulek, James H Revkin, John D Groarke, Lisa C Tarasenko, Mikhail N Kosiborod

2020-Current year OA Pubs

Growth differentiation factor-15 (GDF-15) is an emerging biomarker in several conditions. This SLR, conducted following PRISMA guidelines, examined the association between GDF-15 concentration and range of adverse outcomes in patients with heart failure (HF). Publications were identified from Embase® and Medline® bibliographic databases between January 1, 2014, and August 23, 2022 (congress abstracts: January 1, 2020, to August 23, 2022). Sixty-three publications met the eligibility criteria (55 manuscripts and 8 abstracts; 45 observational studies and 18 post hoc analyses of randomized controlled trials [RCTs]). Of the 19 outcomes identified, the most frequently reported longitudinal outcomes were mortality (n = 32 …

Brief Report: Incidence And Outcomes Of Pediatric Tracheal Intubation-Associated Cardiac Arrests In The Icu-Resus Clinical Trial, Akira Nishisaki, Stuart H Friess, Arushi Manga, Et Al.

2020-Current year OA Pubs

BACKGROUND: Tracheal intubation (TI)-associated cardiac arrest (TI-CA) occurs in 1.7% of pediatric ICU TIs. Our objective was to evaluate resuscitation characteristics and outcomes between cardiac arrest patients with and without TI-CA.

METHODS: Secondary analysis of cardiac arrest patients in both ICU-RESUS trial and ancillary CPR-NOVA study. The primary exposure was TI-CA, defined as cardiac arrest occurred during TI procedure or within 20 min after endotracheal tube placement. The primary outcome was survival to hospital discharge with favorable neurological outcome (Pediatric Cerebral Performance Category score 1-3 or unchanged).

RESULTS: Among 315 children with cardiac arrests, 48 (15.2%) met criteria for TI-CA. …

Mom Is Back, Barbara Rollins

Virginia Dental Journal

For several years Mission of Mercy (MOM) events were curtailed as the risks from COVID-19 outweighed the benefits of the free dental care provided by MOM. While COVID is still with us, the risks of delivering dental care in a large group setting were judged to be manageable by the Virginia Dental Association Foundation’s Board of Directors, and MOM project plans moved forward. As such, “MOM IS BACK!” became the rallying motto, and the number of MOM events increased to nine projects in 2022. Through those nine MOM (and Mini-MOM) projects, some 1,029 patients across the state received over $1.3 …

Ethics And Professionalism, Dana Chamberlain Dds

Virginia Dental Journal

This article examines professionalism in dental ethics, based on a working draft of the 2017 Dental Ethics Primer by Drs. Bruce Peltier and Larry Jenson. It highlights the complexities of ethical decision-making and the responsibilities of dental professionals, who must balance autonomy with a commitment to competence and ethical conduct. The article outlines five key components of professionalism, emphasizing the importance of continuous education, adherence to ethical standards, and the willingness to prioritize patient care over personal interests. True professionalism is portrayed as service-oriented and deeply rooted in trust and ethical responsibility.

Through The Looking Glass, Sarah Glass Dds

Virginia Dental Journal

This article offers a sampling of the fantastical world of oral pathology It includes example images and discusses osseous choristoma, squamous cell carcinoma, traumatic ulcerative granuloma with stromal eosinophilia (TUGSE).

Take Action To Address Virginia’S Dental Workforce Needs, Ryan Dunn

Virginia Dental Journal

This article lays out the facts about the dental workforce situation in Virginia and offers potential solutions. The state's dental workforce is under pressure, with rising demand for dental assistants and hygienists and ongoing hiring challenges exacerbated by the pandemic. Despite having more dentists than the national average, rural areas still face shortages. The Virginia Dental Association (VDA) encourages members to support local dental programs, share their workforce challenges, and participate in advocacy efforts. The VDA is actively involved in finding both short-term and long-term solutions to meet the state's dental care needs.

Va Dent J January, February & March 2023

Virginia Dental Journal

In the January, February and March 2023 issue, the reader will find the following feature articles:

• An Interview with Dr. Richard Roadcap: Virginia Dental Journal Editor (2007 – 2023)
• Through the Looking Glass: The Fantastical World of Oral Pathology
• Treatment Access and Outcomes for Craniofacial Care: Patient and Parent Perspectives
• Cheiloscopy
• We’re Taking on the Fight tor Fairness and Transparency: We Need More Dentists to Join the Fight
• Serving the Petersburg Community: VDA Foundation Collaboration with Central Virginia Health Services

This issue includes regular columns with regional news impacting the Virginia membership including: editorial and perspectives columns, legal, association activities, …

Medical School Watercooler Newsletter - August 29, 2024, Lindsay Hughes

Watercooler Newsletter

This is the August 29, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include

• Medical students publish research study on match outcomes of neurosurgery residents
• Now accepting nominations for 2025 Medical Alumni Association Awards
• Alexeyev receives $1 million NSF grant to develop ‘designer' mitochondria
• Hall joins USA Health as emergency medicine physician
• New hospitalist volunteers her time and training here and abroad 

Combination Therapy Of Ido1 Inhibition And Anti-Pd1 Mediates Anti-Tumor Immunity By Promoting Memory Immunity Development And Cytotoxicity Of Γδ T And Nk Cells Via Il-2 Signaling And By Overcoming Pro-Tumor Effects Of Tgf-Β Signaling, Hyuk Jee

Dartmouth College Master’s Theses

Cutaneous melanoma is the most aggressive form of skin cancer even though it takes only about 1% of all skin cancers. Even among all cutaneous melanomas, NRAS-mutant melanoma is more aggressive than any other, and about 10-25% of all cutaneous melanoma cases have mutations in NRAS. NRAS is a member of the RAS family of proto-oncogenic GTPase proteins, and it plays a key role in signal transduction pathways responsible for cellular survival, proliferation, and metabolism. Immunotherapy is the first line of defense against NRAS-mutant melanoma because, despite tremendous efforts made for decades, it has not been successful to develop small …