Medicine and Health Sciences Commons^™

Glycemic Control In Diabetic Patients Improved Overall Lung Cancer Survival Across Diverse Populations, Wayne Y Wu, Brian Luke, Xiao-Cheng Wu, J Jack Lee, Yong Yi, Samuel C Okpechi, Barry Gause, Paras Mehta, Steven I Sherman, Augusto Ochoa, Ethan Dmitrovsky, Xi Liu

Faculty, Staff and Student Publications

Background: The consequence of diabetes on lung cancer overall survival (OS) is debated. This retrospective study used 2 large lung cancer databases to assess comprehensively diabetes effects on lung cancer OS in diverse demographic populations, including health disparity.

Methods: The University of Texas MD Anderson Cancer Center database (32 643 lung cancer patients with 11 973 patients with diabetes) was extracted from electronic health records (EHRs) using natural language processing (NLP). Associations were between diabetes and lung cancer prognostic features (age, sex, race, body mass index [BMI], insurance status, smoking, stage, and histopathology). Hemoglobin A1C (HgbA1c) and glucose levels assessed …

Scintruler: Guiding The Integration Of Multiple Single-Cell Rna-Seq Datasets With A Novel Statistical Metric, Yue Lyu, Steven H Lin, Hao Wu, Ziyi Li

Faculty, Staff and Student Publications

Motivation: The growing number of single-cell RNA-seq (scRNA-seq) studies highlights the potential benefits of integrating multiple datasets, such as augmenting sample sizes and enhancing analytical robustness. Inherent diversity and batch discrepancies within samples or across studies continue to pose significant challenges for computational analyses. Questions persist in practice, lacking definitive answers: Should we use a specific integration method or opt for simply merging the datasets during joint analysis? Among all the existing data integration methods, which one is more suitable in specific scenarios?

Result: To fill the gap, we introduce SCIntRuler, a novel statistical metric for guiding the integration of …

The Il-6 Hypothesis In Covid-19: A Phase 2, Randomised, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of Free Il-6 Sequestration By The Monoclonal Antibody Sirukumab In Severe And Critical Covid-19, Robert L. Gottlieb, Meredith Clement, Paul Cook, Audra Deveikis, Kap Sum Foong, Philip Robinson, Jihad Slim, Cedric W. Spak, Annemie Buelens, Katleen Callewaert, Sandra De Meyer, Wai Ling Mo, Inge Verbrugge, Liesbeth Van Wesenbeeck, Yanli Zhuang, Jason W. Chien, Magda Opsomer, Erika Van Landuyt

School of Medicine Faculty Publications

Background: Upregulation of IL-6 has been associated with worse prognosis in COVID-19 patients. Impact on IL-6 signalling has mostly been limited to clinical outcomes in IL-6 receptor antagonist trials. Methods: We performed a phase 2, randomised, double-blind, placebo-controlled trial (NCT04380961) of US-based hospitalised adults (< 85 years) with laboratory-confirmed SARS-CoV-2 infection and severe (low levels of supplemental oxygen) or critical disease (high levels of oxygen supplementation). Patients received sirukumab 5 mg/kg or placebo single dose IV on Day 1 plus standard of care. The primary endpoint was time to sustained clinical improvement up to Day 28 based on an ordinal scale. Secondary endpoints included clinical improvement, all-cause mortality, and safety. Following an interim analysis, the protocol was amended to only recruit patients with critical COVID-19. Findings: From May 2020 to March 2021, 209 patients were randomised; 112 had critical disease (72 sirukumab, 40 placebo) at baseline. Median time to sustained clinical improvement in critical patients was 17 and 23 days in the sirukumab and placebo groups (HR, 1∙1; 95% CI, 0∙66–1∙88; p > 0∙05). At Day 28, 59∙4% versus 55∙0% of patients achieved clinical improvement with sirukumab versus placebo and rates of all-cause mortality were 24∙6% versus 30∙0%, respectively. Rates of grade ≥ 3 adverse events were comparable between the sirukumab and placebo groups (25∙9% vs 32∙9%; all patients). Interpretation: In critical COVID-19 patients who received sirukumab, there …

Optimizing Tigertriever Adjustable Stentriever Technique: Operators’ Experience, Brian Jankowitz, Eitan Abergel, Ronit Agid, Abdul Rahman Al-Schameri, Krzysztof Bartosz Kądziołka, Allan Brook, Michael Diepers, Jeffrey Farkas, Johanna Fifi, Sebastian Fischer, Chirag Gandhi, Reid Gooch, Ramesh Grandhi, Guglielmo Pero, Guy Raphaeli, Sudipta Roychowdhury, Shahram Majidi, Christian Paul Stracke, Nader Sourour, Omar Tanweer, Satoshi Tateshima, Phil Taussky, Martin Wiesmann, Albert Yoo, Daniel W Zumofen, Justin Singer

Faculty, Staff and Students Publications

The Tigertriever is a novel, radially adjustable stentriever that addresses limitations in traditional mechanical thrombectomy devices by providing enhanced user control over clot integration. This provides the ability to adapt to patient-specific factors such as varying vessel sizes and clot compositions and may be particularly crucial for ensuring efficacy and safety in distal locations. This consensus paper synthesizes the clinical techniques from a consortium of experienced international operators. It outlines the current data on the Tigertriever, discusses the new operator-controlled capabilities, and provides a recommended approach for both proximal and distal mechanical thrombectomy, emphasizing the "FLEX" approach (Fast Controlled Expansion …

Overcoming Disparities In Hepatocellular Carcinoma Outcomes In First Nations Australians: A Strategic Plan For Action, Jessica Howell, Troy Combo, Paula Binks, Kylie Bragg, Sarah Bukulatjpi, Kirsty Campbell, Paul J. Clark, Melissa Carroll, Jane Davies, Teresa De Santis, Kate R. Muller, Bella Nguyen, John K. Olynyk, Nicholas Shackel, Patricia C. Valery, Alan J. Wigg, Jacob George, Stuart K. Roberts

Research outputs 2022 to 2026

No abstract provided.

Setrusumab For The Treatment Of Osteogenesis Imperfecta: 12-Month Results From The Phase 2b Asteroid Study, Francis H Glorieux, Bente Langdahl, Roland Chapurlat, Suzanne Jan De Beur, Vernon Reid Sutton, Kenneth E S Poole, Kathryn M Dahir, Eric S Orwoll, Bettina M Willie, Nicholas Mikolajewicz, Elizabeth Zimmermann, Seyedmahdi Hosseinitabatabaei, Michael S Ominsky, Chris Saville, James Clancy, Alastair Mackinnon, Arun Mistry, Muhammad K Javaid

Faculty, Staff and Students Publications

Osteogenesis imperfecta (OI) is a rare genetic disorder commonly caused by variants of the type I collagen genes COL1A1 and COL1A2. OI is associated with increased bone fragility, bone deformities, bone pain, and reduced growth. Setrusumab, a neutralizing antibody to sclerostin, increased areal bone mineral density (aBMD) in a 21-week phase 2a dose escalation study. The phase 2b Asteroid (NCT03118570) study evaluated the efficacy and safety of setrusumab in adults. Adults with a clinical diagnosis of OI type I, III, or IV, a pathogenic variant in COL1A1/A2, and a recent fragility fracture were randomized 1:1:1:1 to receive 2, 8, or …

Peritoneal Baclofen Pump Migration: A Rare Complication Of Subfascial Placement Illustrative Cases, Ashley Ricciardelli, Jordan Guntin, Joshua Korb, Daniel J Curry, Nisha Gadgil

Faculty, Staff and Students Publications

BACKGROUND: The intrathecal baclofen pump is an effective treatment option for patients with severe spasticity. In children, subfascial pump placement is often preferred given concerns for infection and wound healing. However, this approach is not without risk, and rare complications, such as peritoneal pump migration, can occur.

OBSERVATIONS: The authors describe three pediatric cases of peritoneal pump migration at their institution over the past 14 years (3/545, 0.5%). All three patients had low body weight (below the 39th percentile), and two had scoliosis requiring surgery. All pumps had been placed using the subfascial technique. The first case occurred 6 months …

Fetal Mavs And Type I Ifn Signaling Pathways Control Zikv Infection In The Placenta And Maternal Decidua, Yael Alippe, Leran Wang, Reyan Coskun, Stéfanie P Muraro, Fang R Zhao, Michelle Elam-Noll, J Michael White, Daiana M Vota, Vanesa C Hauk, Jeffrey I Gordon, Scott A Handley, Michael S Diamond

2020-Current year OA Pubs

The contribution of placental immune responses to congenital Zika virus (ZIKV) syndrome remains poorly understood. Here, we leveraged a mouse model of ZIKV infection to identify mechanisms of innate immune restriction exclusively in the fetal compartment of the placenta. ZIKV principally infected mononuclear trophoblasts in the junctional zone, which was limited by mitochondrial antiviral-signaling protein (MAVS) and type I interferon (IFN) signaling mechanisms. Single nuclear RNA sequencing revealed MAVS-dependent expression of IFN-stimulated genes (ISGs) in spongiotrophoblasts but not in other placental cells that use alternate pathways to induce ISGs. ZIKV infection of Ifnar1-/- or Mavs-/- placentas was associated with greater …

Analysis Of Ductal Carcinoma In Situ By Self-Reported Race Reveals Molecular Differences Related To Outcome, Siri H Strand, Graham A Colditz, Et Al.

2020-Current year OA Pubs

BACKGROUND: Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer (IBC). Studies have indicated differences in DCIS outcome based on race or ethnicity, but molecular differences have not been investigated.

METHODS: We examined the molecular profile of DCIS by self-reported race (SRR) and outcome groups in Black (n = 99) and White (n = 191) women in a large DCIS case-control cohort study with longitudinal follow up.

RESULTS: Gene expression and pathway analyses suggested that different genes and pathways are involved in diagnosis and ipsilateral breast outcome (DCIS or IBC) after DCIS treatment in White versus …

Catalyst For Change: Evaluating The Effects Of The Citizen Nurse Education, Kathleen M. Clark Dnp, Rn, Amy K. Nelson Phd, Rn, Katherine Martin Phd, Aprn, Cnm, Michelle Ullery Dnp, Aprn, Cnp, Elaine Eschenbacher Ma

Faculty Authored Articles

Background:

The purpose of this qualitative study was to evaluate the effects of curricular changes made to foster graduate students' understanding of how they can be catalysts of change. For more than a decade, the concept of the citizen nurse has been woven into coursework in nursing education, thus indicating an evaluation process was needed.

Method:

Ten oral history interviews were completed with current students or alumni. Data were analyzed for codes, allowing the final themes to emerge.

Results:

Two main themes emerged. Students reported (1) having a new understanding of what it means to be a nurse and (2) …

Himmelfarb Headlines - September/October 2024, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News, information, and resources relating to Himmelfarb Library that is of interest to patrons.

Understanding Your Sepsis Diagnosis (Español), Providence Mmhm

Posters with QR Codes

Please see additional files:

1. Patient Education Graphic: Understand Your Sepsis Diagnosis
2. Patient Education Flyer: SEPTICEMIA Todo lo que necesita saber / SEPSIS What You Need to Know (Spanish)

The Behavioral Medicine Nurse - An Innovative Approach To Today's Challenges, Gina Stjean Rn, Debra Baker Rn, Megan Thompson Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Evaluating The Perceived Value Of Holistic Certification Among Nurses Using The Pvct-12 Tool, Cidalia Vital Rn, Deborah Naglieri-Prescod Phd, Cynthia Peterson Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Breaking New Ground: An Innovative Approach To Standardizing Behavioral Health Onboarding Education In The Pediatric Emergency Department, Kristen Whitehead Rn, Mikaela Decosmo Rn, Elizabeth Farrell Bs

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

The Development And Testing Of An Instrument To Measure Perceptions Of Body Art Among Nurse Educators And Nursing Students, Deana Nunes Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Developing A Device For Confidential And Unbiased Sound Identification: Research For Noise Reduction In Healthcare Settings, Seonhun Lee Ms, Gina Georgadarellis Ms, Brenda Nyarko Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Navigating Safe Discharge: Improving Medication Reconciliation On Springfield 3 Discharge, Christina Raco Rn, Lucy Francisco Rn, Kimberly Bean Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Collaboration Between Nurses & Engineers: Design Of A Defibrillator Handle, Gina Georgadarellis Ms, Seohun Lee Ms, Ken Suzuki

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Improving Identification And Care Delivery To Visually Impaired Patients Through A Nurse Practice Guideline, Anne-Marie Albano Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Travel Nurses: A Review Of The Literature, Sarah Romain Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Use Of The Georgie Pediatric Gown To Improve Compliance To The Safe Sleep Bundle, Stephanie Adam Rn, Trish Fontaine Rn, Jennifer Gardner

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Sips Of Joy: Providing Positive Affirmations To Oncology Patients, Krystal Aguayo Rn, Mary Godin Rn, Brooke Chisholm Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Just Breathe: The Box Breathing Technique With Nicu Nurses, Amy Belanger Rn, Brenda Jones Rn, Jennifer Marion Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Caring Moments For Healthcare Staff On An Acute Care Floor, David Bennett Rn, Janine Cardello Rn, Ilene Matos

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Acts Of Random Kindness In A Level 1 Trauma Center, Kelly Famiglietti Rn, Loretta Kapinos Rn, Jessica Hannington Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Confusion Assessment Method Compliance And Importance, Caitlyn Waddell Rn, Cidalia Vital Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

A Mindful Moment: Using Mindfulness To Combat Burnout, Colleen Bennett Rn, Shannon Dube Rn, Jacquelyn Fouche Rn, Cidalia Vital Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Transformation Of A System-Wide Nursing Team Orientation: Bridging The Past With The Future, Arlene Kruzel Rn, Stephanie Swan Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.

Supporting Onboarding & Achieving Role Readiness Education Program: Nurse Residents “Soarr” Into Nsi Speed Dating, Julie Racicot Rn

Holistic & Nursing Scholarship Symposium - 2024

No abstract provided.