Medicine and Health Sciences Commons^™

Exploring The Relationship Between Covid-19 Transmission And Population Mobility Over Time, Tanmoy Bhowmik, Naveen Eluru

Civil and Environmental Engineering Faculty Publications and Presentations

This study explores the dynamic relationship between COVID-19 transmission and transportation mobility, with an emphasis on understanding the time-varying bidirectional interplay across the different phases of the pandemic. To gain insight into this relationship, we analyzed county-level data on transmission and mobility patterns from the United States over a 74-week period using a comprehensive list of factors including: temporal factors, socio-demographics, health indicators, health care infrastructure attributes, and spatial factors. For our analysis, we proposed a simultaneous econometric model system that explicitly accounts for the bidirectional relationship between COVID-19 transmission and mobility patterns while also accounting for the influence of …

Generalized Encoding Of The Relative Subjective Value Of Cognitive Effort In The Dorsal Acc, Jennifer L Crawford, Rachel E Brough, Sarah A Eisenstein, Jonathan E Peelle, Todd S Braver

2020-Current year OA Pubs

Making choices about whether and when to engage cognitive effort are a common feature of everyday experience, with important consequences for academic, career, and health outcomes. Yet, despite their hypothesized importance, very little is understood about the underlying mechanisms that support this form of human cost-benefit decision-making. To investigate these mechanisms, we used the Cognitive Effort Discounting Paradigm (Cog-ED) during fMRI scanning to precisely quantify the neural encoding of varying cognitive effort demands relative to reward outcomes, within two distinct cognitive domains (working memory, speech comprehension). The findings provide strong evidence that the dorsal anterior cingulate cortex (dACC) plays a …

Positron Emission Tomography (Pet) In Presurgical Planning Of Anterior Temporal Lobectomy: A Systematic Review Of Efficacy And Limitations, Eric M. Teichner, Robert C Subtirelu, Shiv Patil, Chitra Parikh, Arjun Ashok, Sahithi Talasila, Victoria Anderson, Talha Khan, Yvonne Su, Thomas Werner, Abass Alavi, Mona-Elisabeth Revheim

SKMC Student Presentations and Publications

INTRODUCTION: Temporal lobe epilepsy (TLE), a debilitating neurological disorder, necessitates refined diagnostic and treatment strategies. This comprehensive review appraises the potential of positron emission tomography (PET) in enhancing the presurgical planning of Anterior Temporal Lobectomy (ATL) for patients afflicted with TLE.

METHODS: A comprehensive literature search was conducted using the PubMed, SCOPUS, and ScienceDirect databases from 1985 to 2022, following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for studies investigating PET and ATL. This review studied a range of radiotracers, including FDG, H

RESULTS: A total of 52 studies were included in the final analysis. Our …

Synovial Fluid Cutibacterium Acnes Antigen Is Detected Among Shoulder Samples With High Inflammation And Early Culture Growth, Krista Toler, Pearl Paranjape, Alex Mclaren, Thomas Jefferson University

Rothman Institute Papers

Background: An emerging paradigm suggests that positive Cutibacterium acnes shoulder cultures can result from either true infection or contamination, with true infections demonstrating a host inflammatory response and early culture growth. This clinical retrospective study examines the relationship between C. acnes antigen, C. acnes culture results, and inflammation.

Methods: From January 2021 to July 2023, 1,365 periprosthetic synovial fluid samples from 347 institutions were tested for shoulder infection at a centralized clinical laboratory. A biomarker scoring system based on the 2018 International Consensus Meeting (ICM) definition was utilized to assign each sample an inflammation score. Associations between inflammation, culture results, …

Removal Of Common Antimicrobial Agents By Sustained Low- Efficiency Dialysis, Joanna Q. Hudson Pharmd, Bcps, Fasn, Fccp, Madelyn N. Hilgers Bs, Pharmd Candidate, Elvira O. Gosmanova Md

Faculty Publications

Adequate dosing of antimicrobials is paramount for treating infections in critically ill patients undergoing kidney replacement therapy; however, little is known about antimicrobial removal by sustained low-efficiency dialysis (SLED). The objective was to quantify the removal of cefepime, daptomycin, meropenem, piperacillin–tazobactam, and vancomycin in patients undergoing SLED. Adult patients ≥18 years with acute kidney injury (AKI) or end-stage kidney disease receiving one of the select antimicrobials and requiring SLED were included. Blood and dialysate flow rates were maintained at 250 and 100 mL/min, respectively. Simultaneous arterial and venous blood samples for the analysis of antibiotic concentrations were collected hourly for …

Obesity-Facilitated Colon Cancer Progression Is Mediated By Increased Diacylglycerol O-Acyltransferases 1 And 2 Levels, Jenisha Ghimire, Morgan E. Collins, Patricia Snarski, Angelle N. King, Emmanuelle Ruiz, Rida Iftikhar, Harrison M. Penrose, Krzysztof Moroz, Tyler Rorison, Melody Baddoo, Muhammad Anas Naeem, Arnold H. Zea, Scott T. Magness, Erik F. Flemington, Susan E. Crawford, Suzana D. Savkovic

School of Medicine Faculty Publications

BACKGROUND & AIMS: The obesity epidemic is associated with increased colon cancer progression. As lipid droplets (LDs) fuel tumor growth, we aimed to determine the significance of diacyltransferases (diacylglycerol o-acyltransferases 1 and 2 [DGAT1/2]), responsible for LD biogenesis, in obesity-mediated colonic tumorigenesis. METHODS: Human colon cancer samples, colon cancer cells, colonospheres, and Apc colon cancer mouse model on a high-fat diet were employed. For DGAT1/2 inhibition, enzymatic inhibitors and small interfering RNA were used. Expression, pathways, cell cycle, and growth were assessed. Bioinformatic analyses of CUT&RUN and RNA sequencing data were performed. RESULTS: DGAT1/2 levels in human colon cancer tissue …

Nanofiber-Hydrogel Composite Scaffold Fabrication Methods For Peripheral Nerve Regeneration, Jacob Lee Carter

Theses and Dissertations

Nerve graft conduits (NGCs) are a rapidly advancing field for treating peripheral nerve injuries that aim to guide the growth of regenerating axons across damaged gaps. A more effective NGC can be manufactured by combining the use of nanofibers to act as guidewires within a 3-D hydrogel that imitates the extracellular matrix of nerve tissue. Several methods have been developed to embed aligned nanofibers in an ordered architecture within a hydrogel matrix. The first method involves layer-by-layer additive manufacturing to create NGCs with rows of polycaprolactone (PCL) nanofibers surrounded by a gelatin methacrylate (GelMe) hydrogel in a 3-D structure. A …

Global Trends In Type 1 Diabetes In Adolescents And Young Adults (1990–2019), Jessy Louisa Silfer, Ksenia N. Tonyushkina

Faculty Scholarship

The study by Gong et al. examines the increases in the incidence, prevalence, and burden trends of type 1 diabetes (T1D) in adolescents and young adults over a 30-year span (1990 – 2019) by age, sex, and geographical regions based on the data from the 204 countries and territories included in the Global Burden of Disease (GBD) collaborative.1 Burden is defined as a combination of mortality rates and disability adjusted life year (DALY) indexes. The results of this 3-decade study should be interpreted within the milieu of improvements in the diagnosis and treatment of T1D over this period as well …

Exploring Barriers To Effective Covid-19 Risk Mitigation, Recovery, And Chronic Disease Self-Management: A Qualitative Multilevel Perspective, Gayenell S. Magwood Phd, Rn, Faha, Faan, Charles Ellis, Chanita Hughes Halbert, Ebony Allen Toussaint, Jewel Scott Phd, Rn, Fnp-C, Lynne S. Nemeth

Publications

INTRODUCTION: Many research activities have focused on SARS-CoV-2 infection and subsequent COVID-19 respiratory illness during the pandemic. However, significant racial inequities emerged months after the COVID-19 pandemic began. The similarity between racial/ ethnic disparities in COVID-19 and those for other diseases raised awareness about the context for risk exposure and healthcare access. The purpose of this study is to examine social and structural determinants of health among COVID-19 survivors, carepartners, and the perspectives of healthcare stakeholders who experienced disruption during the early pandemic. MATERIAL AND METHODS: A purposive sample of interviews (n=9) and focus groups (n=10) were used to collect …

Exploring Barriers To Effective Covid-19 Risk Mitigation, Recovery, And Chronic Disease Self-Management: A Qualitative Multilevel Perspective, Gayenell S. Magwood Phd, Rn, Faha, Faan, Charles Ellis Jr, Chanita Hughes Halbert, Ebony Allen Toussaint, Jewel Scott Phd, Rn, Fnp-C, Lynne S. Nemeth

Faculty Publications

Introduction: Many research activities have focused on SARS-CoV-2 infection and subsequent COVID-19 respiratory illness during the pandemic. However, significant racial inequities emerged months after the COVID-19 pandemic began. The similarity between racial/ ethnic disparities in COVID-19 and those for other diseases raised awareness about the context for risk exposure and healthcare access. The purpose of this study is to examine social and structural determinants of health among COVID-19 survivors, carepartners, and the perspectives of healthcare stakeholders who experienced disruption during the early pandemic.
Material and methods: A purposive sample of interviews (n=9) and focus groups (n=10) were used to collect …

Influences Of Quality Of Maternal Care And Environmental Enrichment On Associative Memory Function In Rats With Early Life Lead Exposure, Jay S. Schneider, Courtney Williams, Shamaila Zafar, Jaehyun Joo, Blanca E. Himes

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

INTRODUCTION: Children in low socioeconomic status (SES) communities are at higher risk of exposure to lead (Pb) and potentially more severe adverse outcomes from Pb exposures. While the factors encompassing SES are complex, low SES households often have less enriching home environments and parent-child interactions. This study investigated the extent to which environmental/behavioral factors (quality of maternal care and richness of the postnatal environment) may modify adverse effects from Pb exposure.

METHODS: Long-Evans female rats were randomly assigned to Control (no Pb), Early Postnatal (EPN: birth through weaning), or Perinatal (PERI: 14 days pre-mating through weaning) Pb exposure groups. From …

Adaptation Of The Socioecological Model To Address Disparities In Engagement Of Black Men In Prostate Cancer Genetic Testing, Amy Leader, Timothy Rebbeck, William Oh, Alpa Patel, Eric Winer, Leeann Bailey, Leonard Gomella, Crystal Lumpkins, Isla Garraway, Lisa Aiello, Monica Baskin, Heather H Cheng, Kathleen Cooney, Amanda Ganzak, Daniel George, Susan Halabi, Feighanne Hathaway, Claire Healy, Joseph W Kim, Michael Leapman, Stacy Loeb, Kara Maxwell, Christopher Mcnair, Todd Morgan, Breanne Prindeville, Howard R Soule, Whitney Steward, Sakinah Suttiratana, Mary-Ellen Taplin, Kosj Yamoah, Thierry Fortune, Kris Bennett, Joshua Blanding-Godbolt, Laura Gross, Veda Giri

Department of Medical Oncology Faculty Papers

BACKGROUND: Black men consistently have higher rates of prostate cancer (PCA)- related mortality. Advances in PCA treatment, screening, and hereditary cancer assessment center around germline testing (GT). Of concern is the significant under-engagement of Black males in PCA GT, limiting the benefit of precision therapy and tailored cancer screening despite longstanding awareness of these disparities. To address these critical disparities, the Socioecological Model (SEM) was employed to develop comprehensive recommendations to overcome barriers and implement equitable strategies to engage Black males in PCA GT.

METHODS: Clinical/research experts, national organization leaders, and community stakeholders spanning multiple regions in US and Africa …

Rethinking Health Systems Responsiveness In Low- And Middle-Income Countries: Validation Study, Meesha Iqbal, Cecilia Ganduglia Cazaban, Robert Morgan, Cici Bauer, Sameen Siddiqi

Faculty, Staff and Student Publications

BACKGROUND: Health systems responsiveness (HSR) is the ability of systems to respond to legitimate non-health expectations of the population. The concept of HSR by the World Health Organization (WHO) includes respect for dignity, individual autonomy, confidentiality, prompt attention to care, availability of basic amenities, choice of provider, access to social support networks, and clarity of communication. The WHO tool is applied globally to assess HSR in low, middle, and high-income countries.

OBJECTIVE: We have revised the conceptual framework of HSR following a rigorous systematic review and made it specific for low- and middle-income countries (L&MICs). This study is designed to …

Fueling The Heart: What Are The Optimal Dietary Strategies In Heart Failure?, Anahita Ataran, Alexander Pompian, Hamidreza Hajirezaei, Rehman Lodhi, Ali Javaheri

2020-Current year OA Pubs

OBJECTIVES: Heart failure (HF) is a global health concern with rising incidence and poor prognosis. While the essential role of nutritional and dietary strategies in HF patients is acknowledged in the existing scientific guidelines and clinical practice, there are no comprehensive nutritional recommendations for optimal dietary management of HF.

METHODS: In this review, we discuss results from recent studies on the obesity paradox and the effects of calorie restriction and weight loss, intermittent fasting, the Western diet, the Mediterranean diet, the ketogenic diet, and the DASH diet on HF progression.

RESULTS: Many of these strategies remain under clinical and basic …

Design Of A Tool Capable Of Assessing Environmental Sociocultural Physical Factors Influencing Women's Decisions On When And Where To Toilet Within Real-World Settings: Protocol For The Build And Usability Testing Of A Mobile App For Use By Community-Dwelling Women, Janis M Miller, Jean F Wyman, Lawrence An, Haitao Chu, Cynthia S Fok, Missy Lavender, Cora Elizabeth Lewis, Alayne D Markland, Leslie M Rickey, Ying Sheng, Siobhan Sutcliffe, Lisa Kane Low, Elizabeth R Mueller

2020-Current year OA Pubs

BACKGROUND: Although surveys and apps are available for women to report urination and bladder symptoms, they do not include their decisions regarding toileting. Real-world factors can interfere with toileting decisions, which may then influence bladder health. This premise lacks data per want of a robust data collection tool.

OBJECTIVE: The Prevention of Lower Urinary Tract Symptoms (PLUS) research consortium engaged a transdisciplinary team to build and test WhereIGo, a mobile data collection app for Android and iOS. The design goal was a comprehensive reporting system for capturing environmental, sociocultural, and physical factors that influence women's decisions for toileting. Aims include …

Effect Of Whole Bowel Irrigation For Ingested Lead-Containing Foreign Bodies: A Pediatric Case Series, Frank Dicker, Michael Mullins, David Liss

2020-Current year OA Pubs

No abstract provided.

Benzodiazepine Receipt In Adults With Psychogenic Non-Epileptic Seizures In The Usa, Kevin Young Xu, Fábio A Nascimento, Binx Yezhe Lin, Tae Woo Park, Donovan T Maust, Hillary Samples, Greta A Bushnell

2020-Current year OA Pubs

BACKGROUND: Characterising benzodiazepine (BZD) prescribing to individuals with psychogenic non-epileptic seizures (PNES) is important for optimising PNES outcomes, but existing data is lacking.

METHODS: Using a nationwide administrative claims database (2016-2022), incident PNES was defined as an International classification of diseases, tenth revision, clinical modification (ICD-10-CM) diagnosis in an inpatient or outpatient healthcare encounter after a 1-year period with no documented diagnosis. We described clinical characteristics of adults with incident PNES and estimated the prevalence of outpatient BZD treatment in the baseline year and 30-day follow-up period, with secondary analyses stratifying by baseline ES, anxiety and/or insomnia diagnoses, representing common …

Efficiency Of One Against One Game Situations In Polish Soccer National Team And Their Opponents During Uefa European Championship Matches, Andrzej Szwarc, Krzysztof Kromke, Henryk Duda, Andrzej Soroka, Lukasz Radziminski

Baltic Journal of Health and Physical Activity

Introduction: The purpose of this study was to assess the efficiency in one against one (1v1) game situations of Polish national team soccer players and their opponents in 12 matches of the group stage in 4 consecutive cup finals at the European Championship in the years 2008–2021. Material and methods: Audio-visual records of matches were analysed and data about the game were recorded on a self-developed observation sheet. Activity, effectiveness and reliability of individual offensive and defensive actions were assessed in the context of implementation of the game objectives. Results: It was found that the Polish players were involved in …

Wmdds Bulletin Winter 2021

West Michigan District Dental Society Bulletin

In the Winter 2021 issue, the reader will find the following feature articles:

• Seeking Out COVID-19 Vaccine Information
• Dentists Beyond the Chair: Trap and Skeet Shooting, Judd Carroll, DMD

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Spring 2021

West Michigan District Dental Society Bulletin

In the Spring 2021 issue, the reader will find the following feature articles:

• Be Part of the Solution: The Dental Needs of Refugee and Immigrant Youth
• Dentists Beyond the Chair: Monoskiing, Jeffrey Heinz, DDS, MSD

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Summer 2021

West Michigan District Dental Society Bulletin

In the Summer 2021 issue, the reader will find the following feature articles:

• Doppelgangers: Katie Swan and Katie Swanson
• GRCC 2021 Graduation Highlights

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Holiday 2021

West Michigan District Dental Society Bulletin

In the Holiday 2021 issue, the reader will find the following feature articles:

• Spectrum Health Youth Behavioral Health Initiatives: Increasing Dental Provider Awareness
• Dentists Doing Good: Local WMDDS Dentists Doing GREAT
• Free CE and Certification: Penn Dental Medicine’s Person with Disabilities Series

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Wmdds Bulletin Fall 2021

West Michigan District Dental Society Bulletin

In the Fall 2021 issue, the reader will find the following feature articles:

• Cover Story: Introducing Maxillofacial Prosthodontics to West Michigan
• Dentists Beyond the Chair: Wolverine One

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Perceptions Of Pharmacy Students Towards The Transition To Online Communication In Learning: Lessons From The Covid-19 Pandemic, Wejdan Shroukh Dr

Middle East Journal of Communication Studies

This study aims to explore the experiences of pharmacy students at Middle East University (MEU) in the transition to online communication in pharmacy education during the COVID-19 pandemic in the academic year 2021/2022.The current study follows an inductive qualitative research design based on conducting semi-structured interviews with students. Thematic analysis of data was carried out, and the six phases of analysis described by Braun and Clarke were followed. Data analysis yielded the following themes: acceptance of the transition to online communication in pharmacy education, the perceived difficulty of online courses delivered during the pandemic, drawbacks of online communication in pharmacy …

2024 September 17 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Trends In Pediatric Opioid Prescribing And Use, Robert W. Steele, Michelle Dephillips

Pediatrics in Practice: A CME Podcast

In this episode, Dr. Michelle DePhillips leads a discussion focusing on the rising trend in opioid prescribing, and its effects on global health.

Click here to stream the podcast episode.

System And Method For Autometic Labeling Of Pathology Images, Kevin Lee Matlock, Ganapati Srinivasa, Carlo Bifulco, Brian D. Piening

Technology Transfer - Patents

No abstract provided.

Mapping Health-Related Quality Of Life Of Children And Families Receiving Pediatric Invasive Home Mechanical Ventilation: A Scoping Review Protocol, Keisha White Makinde, Maysara Mitchell, Alexandra F Merz, Michael Youssef

2020-Current year OA Pubs

BACKGROUND: Children utilizing invasive home mechanical ventilation (administered via tracheostomy tube) receive intensive care at home without the support of trained staff typically present in an intensive care unit; within the context of worsening home nursing shortages, much of the 24/7 care burden falls to families which are likely under supported. Prior reviews have explored the quality of life of children receiving various forms of mechanical ventilation, without addressing the impact on the family. Additionally, the literature inconsistently differentiates the unique experience of families with children using invasive home mechanical ventilation from non-invasive, which has lower morbidity and mortality and …

Heat-Related Emergencies In The Older Adult, Michelle I. Suh

Journal of Geriatric Emergency Medicine

n/a

Impact Of An Online Decision Support Tool For Ductal Carcinoma In Situ (Dcis) Using A Pre-Post Design (Aft-25), Elissa Ozanne, Kellyn Maves, Angela Tramontano, Thomas Lynch, Alastair Thompson, Ann Partridge, Elizabeth Frank, Deborah Collyar, Desiree Basila, Donna Pinto, Terry Hyslop, Marc Ryser, Shoshana Rosenberg, E. Shelley Hwang, Rinaa Punglia

Department of Pharmacology and Experimental Therapeutics Faculty Papers

BACKGROUND: The heterogeneous biology of ductal carcinoma in situ (DCIS), as well as the variable outcomes, in the setting of numerous treatment options have led to prognostic uncertainty. Consequently, making treatment decisions is challenging and necessitates involved communication between patient and provider about the risks and benefits. We developed and investigated an interactive decision support tool (DST) designed to improve communication of treatment options and related long-term risks for individuals diagnosed with DCIS.

FINDINGS: The DST was developed for use by individuals aged > 40 years with DCIS and is based on a disease simulation model that integrates empirical data and …