Medicine and Health Sciences Commons^™

At A Crossroads: The Crucial Role Of Pharmacists In Healthcare Teams To End The Hiv Epidemic, Jerika Lam, Jennifer M. Cocohoba

Pharmacy Faculty Articles and Research

"Therapeutic advances in treatment and prevention have slowed the human immunodeficiency virus (HIV) epidemic, yet the virus and complications related to it still claim an alarming 630,000 lives globally every year.^1,2 The United States’ goals for the Ending the HIV Epidemic (EHE) initiative include reducing new infections by 90% by the year 2030 and advancing health equity through key treatment and prevention initiatives.³ Multiple agencies, professions, and patient groups are working diligently to achieve the EHE goals. Pharmacists have long recognized that our profession is a key resource in ending the HIV epidemic. We demonstrate this in the …

Longitudinal Development Of Resting-State Functional Connectivity In Adolescents With And Without Internalizing Disorders, Eline F. Roelofs, Janna Marie Bas-Hoogendam, Anderson M. Winkler, Nic J.A. Van Der Wee, Robert R.J. M. Vermeiren

School of Medicine Publications

Longitudinal studies using resting-state functional magnetic resonance imaging (rs-fMRI) focused on adolescent internalizing psychopathology are scarce and have mostly investigated standardized treatment effects on functional connectivity (FC) of the full amygdala. The role of amygdala subregions and large resting-state networks had yet to be elucidated, and treatment is in practice often personalized. Here, longitudinal FC development of amygdala subregions and whole-brain networks are investigated in a clinically representative sample. Treatment-naïve adolescents with clinical depression and comorbid anxiety who started care-as-usual (n = 23; INT) and healthy controls (n = 24; HC) participated in rs-fMRI scans and questionnaires at baseline (before …

Amino Acid-Based Protein-Mimic Hydrogel Incorporating Pro-Regenerative Lipid Mediator And Microvascular Fragments Promotes The Healing Of Deep Burn Wounds, Yan Lu, Shanchun Su, Chih Chang Chu, Yuichi Kobayashi, Abdul Razak Masoud, Hongying Peng, Nathan Lien, Mingyu He, Christopher Vuong, Ryan Tran, Song Hong

School of Medicine Faculty Publications

Pro-regenerative lipid mediator 1 (PreM1) is a specialized pro-resolving lipid mediator that promotes wound healing and regenerative functions of mesenchymal stem cells (MSCs), endothelial cells, and macrophages. The healing of third-degree (3°) burns and regenerative functions of MSCs are enhanced by ACgel1, an arginine-and-chitosan-based protein-mimic hybrid hydrogel. Adipose-tissue derived microvascular fragments (MVFs) are native vascularization units and a rich source of MSCs, endothelial cells, and perivascular cells for tissue regeneration. Here we describe an innovative PreM1-MVFs-ACgel1 construct that incorporated PreM1 and MVFs into ACgel1 via optimal design and fabrication. This construct delivered PreM1 to 3°-burn wounds at least up to …

Chronic Graft-Versus-Host Disease: Unresolved Complication Or Ancient History?, Joseph A Pidala, Ted A Gooley, Leo Luznik, Bruce R Blazar

Faculty, Staff and Students Publications

Chronic graft-versus-host disease (cGVHD) is associated with morbidity, mortality, impaired quality of life, prolonged immunosuppressive therapy, and infection risk after allogeneic hematopoietic cell transplantation (HCT). Major strides have occurred in the understanding of cGVHD biology; National Institutes of Health Consensus meetings have refined rigorous approaches to diagnosis, staging, and response criteria; major interventional trials have established standard benchmarks for treatment outcome; and 3 agents to date have been US Food and Drug Administration approved for treating corticosteroid-refractory cGVHD. Promising results from several recent trials have led some, but not others, to conclude that the risk of developing cGVHD is sufficiently …

Using Syndromic Surveillance For Unintentional And Undetermined Intent Drowning Surveillance In A Large Metropolitan Area, Rohit P Shenoi, Briana Moreland, Jennifer L Jones, Nicholas Peoples, Elizabeth A Camp, Ned Levine

Faculty, Staff and Students Publications

INTRODUCTION: A drowning definition is available for use with National Syndromic Surveillance Program (NSSP) data. However, its accuracy in capturing drowning emergency department and urgent care visits at the regional level is unknown. We tested the ability of the syndromic surveillance (SS) definition in capturing unintentional and undetermined intent drowning (UUID) and describe UUID SS visit trends in a large metropolitan area.

METHODS: We applied the drowning definition to NSSP data from 2016 to 2022 for the 8-county metropolitan Houston region. We queried the dataset for UUID ICD-10-CM codes and manually reviewed the chief complaint (CC) and discharge diagnosis (DD) …

Sequencing-Based Detection Of Avian Influenza A(H5n1) Virus In Wastewater In Ten Cities, Michael J Tisza, Blake M Hanson, Justin R Clark, Li Wang, Katelyn Payne, Matthew C Ross, Kristina D Mena, Anna Gitter, Sara J Javornik Cregeen, Juwan Cormier, Vasanthi Avadhanula, Austen Terwilliger, John Balliew, Fuqing Wu, Janelle Rios, Jennifer Deegan, Pedro A Piedra, Joseph F Petrosino, Eric Boerwinkle, Anthony W Maresso

Faculty, Staff and Student Publications

No abstract provided.

Relationship Between Opioid Treatment And Nonpharmacological Chronic Pain Management Interventions And Perceived Effectiveness Of Managing Chronic Pain In African American Adults, Bona Eze

Walden Dissertations and Doctoral Studies

Chronic pain impacts all areas of life for most Americans, but the issue is particularly salient among African Americans (AAs) as they face adverse pain outcomes. There is little understanding of pain management strategies used by AAs to inform pain management recommendations. The purpose of this study, guided by the COM-B model and biopsychosocial theory, was to determine if there were a relationships between opioid treatment and perceived effectiveness of managing chronic pain in AA adults who are 18 years and older as well as between nonpharmacological interventions (physical therapy, chiropractic care, talk therapy, self-management program, yoga, massage) and perceived …

Early Results Of An Innovative Scalable Digital Treatment For Diabetes Distress In Families Of School-Age Children With Type 1 Diabetes., Susana R. Patton, Jessica S. Pierce, Nicole Kahhan, Matthew Benson, Mark A. Clements, Larry A. Fox

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: This paper reports on the initial outcomes of a new mHealth intervention to reduce diabetes distress (DD) in families of school-age children living with type 1 diabetes (T1D) entitled, 'Remedy to Diabetes Distress' (R2D2).

METHODS: We randomized 34 families (mean child age = 10 ± 1.4 years; 53% male, 85% White, mean HbA1c = 7.24 ± 0.71%) to one of three delivery arms differing only by number of telehealth visits over a 10-week period: zero visits = self-guided (SG), three visits = enhanced self-guided (ESG), or eight visits = video visits (VV). All families had 24 × 7 access …

Effect Of An In-Home Palivizumab Administration Program For Children With Medical Complexity, Hina Emanuel, Aravind Yadav, Julie C Eapan, Maria Caldas-Vasquez, Tomika S Harris, Katrina Mcbeth, Fatima Boricha, Janice John, Ivan G Magana Ceballos, Giuseppe N Colasurdo, Maria E Tellez, Tina Reddy, Wilfredo De Jesús-Rojas, Ricardo A Mosquera

Faculty, Staff and Student Publications

Background: In-home palivizumab administration programs (PH) have shown promise in reducing RSV-associated infections. These programs may be particularly beneficial for children with medical complexity (CMC) by limiting their exposure to healthcare-associated infections (HAIs) from non-RSV-related pathogens during transportation and visits to medical facilities.

Methods: In this prospective study, 41 children with CMC less than 2 years of age were randomized by their health insurance to receive PH or in the clinic (PC) during the RSV season (October 2018-April 2019). Patients were stratified by home ventilation. The primary outcome was the total number of face-to-face encounters. Secondary outcomes were unscheduled clinic …

Sequencing-Based Detection Of Avian Influenza A(H5n1) Virus In Wastewater In Ten Cities, Michael J Tisza, Blake M Hanson, Justin R Clark, Li Wang, Katelyn Payne, Matthew C Ross, Kristina D Mena, Anna Gitter, Sara J Javornik Cregeen, Juwan Cormier, Vasanthi Avadhanula, Austen Terwilliger, John Balliew, Fuqing Wu, Janelle Rios, Jennifer Deegan, Pedro A Piedra, Joseph F Petrosino, Eric Boerwinkle, Anthony W Maresso

Faculty, Staff and Students Publications

No abstract provided.

Molecular Testing Of Environmental Samples As A Potential Source To Estimate Parasite Infection, Rojelio Mejia, Barton Slatko, Cristina Almazan, Ruben Cimino, Alejandro Krolewiecki, Natalia Montellano Duran, Jacob Edwin Valera Aspetty, Paola Andrea Vargas, Chiara Cássia Oliveira Amorim, Stefan Michael Geiger, Ricardo Toshio Fujiwara, Juan David Ramirez, Luz Marina Llangarí-Arizo, Irene Guadalupe, Liliana E Villanueva-Lizama, Julio Vladimir Cruz-Chan, María Leticia Ojeda, Eva Mereles Aranda, Sandra Ocampos Benedetti, Maritza Dalí Camones Rivera, Eddyson Montalvo Sabino, Carlos Pineda, Eric J Wetzel, Philip J Cooper

Faculty, Staff and Students Publications

We discuss the potential usefulness of molecular testing of soil, dust, and water samples to detect medically important parasites, and where such testing could be used to supplement stool sampling in humans. A wide variety of parasites including protozoa and helminths, many of which are zoonotic, have an important infection reservoir in the environment. In some cases, this environmental period is essential for further parasite development. We describe the progress in implementing methods for the molecular detection of these parasites in soil across eight collaborating centers in Latin America and represent a variety of potential applications in improving our understanding …

Untargeted Metabolomic Biomarker Discovery For The Detection Of Ectopic Pregnancy, Onur Turkoglu, Ayse Citil, Ceren Katar, Ismail Mert, Robert A Quinn, Ray O Bahado-Singh, Stewart F Graham

Faculty, Staff and Students Publications

Ectopic pregnancy (EP) is the leading cause of maternal morbidity and mortality in the first trimester. Using an untargeted metabolomic approach, we sought to identify putative plasma biomarkers using tandem liquid chromatography-mass spectrometry for the detection of tubal EP. This case-control study included the prospective recruitment of 50 tubal EP cases and 50 early intrauterine pregnancy controls. To avoid over-fitting, logistic regression models were developed in a randomly selected discovery group (30 cases vs. 30 controls) and validated in the test group (20 cases vs. 20 controls). In total, 585 mass spectral features were detected, of which 221 molecular features …

Study Protocol For Writing To Heal: A Culturally Based Brief Expressive Writing Intervention For Chinese Immigrant Breast Cancer Survivors, Qian Lu, Di Lun, Lenna Dawkins-Moultin, Yisheng Li, Minxing Chen, Sharon Hermes Giordano, James W Pennebaker, Lucy Young, Carol Wang

Faculty, Staff and Student Publications

BACKGROUND: This study uses a randomized controlled trial (RCT) to test the health benefits of expressive writing that is culturally adapted for Chinese immigrant breast cancer survivors (BCSs) and to characterize how acculturation moderates the effects of expressive writing interventions.

METHODS: We will recruit Chinese immigrant BCSs (N = 240) diagnosed with stage 0-III breast cancer and within 5 years of completion of primary treatment. Recruitment will occur primarily through community-based organizations and cancer registries. Participants will be randomly assigned either to a control condition to write about neutral topics or to one of two intervention conditions, self-regulation or self-cultivation, …

Durations Of Antibiotic Treatment For Acute Otitis Media And Variability In Prescribed Durations Across Two Large Academic Health Systems, Sophie E Katz, Timothy C Jenkins, Amy B Stein, Gale Thomas, Nancy Koenig, Gary Lucas Starnes, Jason G Newland, Ritu Banerjee, Holly M Frost

2020-Current year OA Pubs

BACKGROUND: Acute otitis media (AOM) accounts for roughly 25% of antibiotics prescribed to children annually. Despite national guidelines that recommend short (5-7 days) durations of antibiotics for children 2 years and older with AOM, most receive long (10 day) courses. This study aims to evaluate antibiotic durations prescribed for children aged 2-17 years with uncomplicated AOM across two pediatric academic health systems, and to assess the variability in prescribed durations between and within each system.

METHODS: Electronic medical record data from 135 care locations at two health systems were retrospectively analyzed. Outpatient encounters for children aged 2-17 years with a …

Treatment Outcomes Among Patients With A Positive Candida Culture Close To Randomization Receiving Rezafungin Or Caspofungin In The Restore Study, Alex Soriano, Marin Kollef, Et Al.

2020-Current year OA Pubs

BACKGROUND: Rezafungin, a novel, once-weekly echinocandin for the treatment of candidemia and/or invasive candidiasis (IC) was noninferior to caspofungin for day 30 all-cause mortality (ACM) and day 14 global cure in the phase 3 ReSTORE trial (NCT03667690). We conducted preplanned subgroup analyses for patients with a positive culture close to randomization in ReSTORE.

METHODS: ReSTORE was a multicenter, double-blind, double-dummy, randomized trial in patients aged ≥18 years with candidemia and/or IC treated with once-weekly intravenous rezafungin (400 mg/200 mg) or once-daily intravenous caspofungin (70 mg/50 mg). This analysis comprised patients with a positive blood culture drawn between 12 hours before …

A Meta-Analysis Comparing Surgical Site Wound Infection Following Single-Incision Versus Multiple-Incision Video-Assisted Thoracoscopic Surgery Lobectomy For Patients With Lung Cancer, Zainab Ayad

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background

A meta-analysis was conducted to evaluate the impact of single-incision (SI) versus multiple-incision (MI) video-assisted thoracoscopic surgery (VATS) lobectomy on surgical site wound length (SSWL) and surgical site wound infection (SSWI) in lung cancer (LC) patients.

Methods

Inclusive literature research till March 2023 was done and 598 interconnected researches were revised. The 8 picked researches, enclosed 1542 LC persons were in the utilized researches' starting point, 310 of them were utilizing SI, and 232 were utilizing MI. Odds ratio (OR) and 95% confidence intervals (CIs) were utilized to appraise the effect of SI compared to MI VATS lobectomy for …

Effect Of Antibiotic Prophylaxis On Surgical Site Wound Infection In Third Molar Surgery: A Meta-Analysis, Mohamed Atif Elkholy, Sayed Rashed Fashkal

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The objective of this meta-analysis is to assess the impact of antibiotic prophylaxis (AP) on surgical site wound infection (SSWI) throughout third molar surgery (TMS).

A meta-analysis was conducted using examinations that compared AP to placebo for TMS from different languages that satisfied the inclusion criteria. Applying dichotomous random or fixed effect models, the findings of these studies were analysed, and the Odd Ratio (OR) was calculated with 95% confidence intervals (CIs).

A total of 18 studies conducted between 2001 and 2023 were included in the present analysis. These studies initially included 4063 individuals with TMS.

A substantial reduction in …

D -∝- Tpgs/ Poloxamer 188 Mixed Micelles For The Oral Delivery Of Azelnidipine: Preparation And In Vitro Evaluation, Ali Kathem Ala Allah, Shaimaa Nazar Abd Alhammid

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Azelnidipine is a calcium channel blocker with low water solubility and high lipophilicity and is intended for treating angina pectoris and hypertension. This study aimed to increase and enhances the solubility of azelnidipine through its incorporation in D - - tocopheryl polyethylene glycol/polyxamer188 (TPGS/P188) micelles for oral administration and substantially increasing the extent of drug absorption.

Nine formulations (A₁-A₉) were prepared by direct dissolution method using a combination of D- - TPGS 1000 succinate and Poloxamer 188. The size of the particle, polydispersity index (PDI), surface charge, and entrapment capacity were measured. The optimum formula …

Evaluation Of Nursing Care Documentation And Administration At Emergency Unite: Comparative Study, Ali Refak Lazem, Huda Baker Hassan

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Objectives: to evaluate of nursing care documentation and administration at emergency unite, and find the relationship between Nursing care documentation and administration and demographic characteristic of nurses.

Method: An Observational design study was conducted from the 25 December 2023 to 30 April 2024. The study setting was conducted at the emergency department in AI-Hussein Teaching Hospital, Al-shatra General Hospital in Dhi-Qar governorate/Iraq. Study Sample A convenient sample (non-probability) involving (103 nurses:60 in Al-Hussien Hospital and 43 in Al-Shatra Hospital). The practices were evaluated by using the self-report questionner and observational checklist. The data analysis through descriptive and interferential statistics …

Occurrence And Diversity Of Staphylococcus From Women With Breast Abscess And Mastitis, Rana Adnan M. Al-Wataify, Maysaa S.M. Al-Shukri, Mohend A.N Al-Shalah

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Mastitis is inflammatory that can effect women at every time , it is predominant occur in women during breastfeeding. Staphylococcus are the most common pathogens causative agents of mastitis.The clincal samples were collection from women with different age group from patients who admitted to Al-Hilla General teaching hospital (breast cancer consultation and outpatient clinics) for the period from August2023 to Januray2024.This study included 80 patient suffered from breast infection or mastitis, this result show that 45(56%) from total samples having breast abscesses and 35(44%) having mastitis.The isolating bacterial causes according of total samples that having S.aureus 20(25%), S.epidermides 10 (12.5%),other …

Economic Factors Affecting Patients Who Use Safety Net Clinics And Food Insecurity In Rio Grande Valley, Michael Machiorlatti, Cliff Clark, Deepu George

Research Colloquium

Food insecurity (FI) is a pervasive problem. It is linked to education and parental SES. The burden is not distributed equally. Younger and older groups are at greater risk along with those who identify with marginalized groups. The purpose of this study was examine how self-reported social determinants are associated with FI in the lower Rio Grande Valley.

The study was conducted at safety net clinics (14) in the RGV from April 1, 2021, to Dec 1, 2021. A common instrument was developed used across the clinics. Goals were to identify what social determinants of health are clients of each …

Autologous Biovesicles Targeted Against Tumor’S Fibrotic Milieu For Management Of Pdac Patients, Sheema Khan

Research Colloquium

Background: One of the major challenges in pancreatic cancer treatment is the management of PDAC following tumor relapse. Relapse may be locoregional and/or metastatic and is highly resistant and impermeable due to a fibrotic stromal tumor microenvironment. Due to highly complex histo-architecture and suboptimal drug accumulation, pancreatic tumors do not respond well to the conventional therapeutic modalities. The application of extracellular vehicles (Evs) is increasing in the field of medicine due to their inherent characteristics as biological cargo vehicles. Therefore, this study investigates the utilization of autologous EVs derived from stromal cells of patient’s matched adjacent normal tissues (NAF-EVs) for …

Interprofessional Learners Lead A Public Health Campaign Addressing Covid-19 Disparities In A Hispanic Community: Lessons Learned And Recommendations, Sabrina R. Orta, Chelsea Chang, Daniela Santos Cantu, Luis R. Torres-Hostos, Giuiseppe Allan Fonseca

Research Colloquium

Purpose:Addressing health disparities through community-engagement and interdisciplinary partnerships is increasingly critical. We designed a learner-led, interdisciplinary, public health campaign for a largely Hispanic community, with the goals of building interdisciplinary leadership skills, engaging learners to address COVID-19 inequities, and disseminating insights learned.

Description: Faculty and students from University of Texas Rio Grande Valley Schools of Medicine and Social Work partnered with RGV community leaders to pilot an interprofessional education program. A 12-member learner team composed of medical students, resident physicians, and social work students was selected from an applicant pool. Learners embarked in interactive didactic sessions to improve their …

Dementia And Stroke Risk Associated With Brain Artery Luminal Diameters, Jesus D. Melgarejo

Research Colloquium

Importance: It is unclear whether brain artery diameters measured on conventional T2-weighted brain MRI images relate to dementia and stroke outcomes across distinct populations.

We aimed this study to evaluate the association of T2-weighted brain artery luminal diameters with dementia and stroke in three distinct population‑based studies.

Methods: Three longitudinal population-based studies with 8420 adults >40 years old (Northern Manhattan Study [NOMAS] from the United States, and the Rotterdam Study [RS], from the Netherlands, and Three-City, from France) with brain MRI scans obtained between 1999 and 2015. The median follow-up time for clinical events ranged between 7 and 12.5 years. …

Gathering And Using Demographic Data For The Rio Grande Valley, Jennifer Cahn, Aniella N. Perez

Research Colloquium

Background: “Statistics are people with the tears wiped away.” Dr. Irving J. Selikoff Statistics, as the quote above suggests, often seem very removed from the lived experience of individuals, particularly in regard to their health concerns. Yet used well, demographic statistics can paint a clear, objective picture of the population being studied, significantly strengthening the validity of research as well as justifying requests for resources such as grant funding.

Method: As a tool for UTRGV researchers, research administrative staff in the School of Medicine have created a demographic table of key data on basic population characteristics including economics, education and …

Novel Strategy To Make Kras Targeted Therapies More Effective For Pdac Treatment, Ana Martinez Bulnes, Melissa Elizondo, Juan Tueme, Aisha Sharif, Orlando Garcia, Poornima Devi Shaji, Swathi Holla, Nirnoy Dan, Anupam Dhasmana, Shabnam Malik, Murali M. Yallapu, Stephen W. Behrman, Subhash C. Chauhan, Sheema Khan

Research Colloquium

Introduction: Pancreatic Ductal Adenocarcinoma (PDAC) patients exhibit extremely poor prognosis. KRAS mutation on codon-12 is present in 70–95% of PDAC cases and it drives PDAC growth and progression. Galectin-1 (Gal-1) is present in both PDAC and stromal cells, being involved in tumor microenvironment, immune cell activation and metastasis. Therefore, this study discusses the efficiency of combined inhibition of mutated KRAS^G12D and Gal-1 inhibition to effectively suppress PDAC growth and progression. For this we have delivered KRAS^G12D inhibiting siRNA (siKRAS^G12D) using a superparamagnetic iron oxide nanoparticle (SPION) and a galectin inhibitor.

Methods: SPION nano-formulation was used to …

Patient Navigation Services In The Rio Grande Valley: Impacts On Clinicians, Students, And Patients, Sabrina R. Orta, Saba Suleman, Samuel Alvarez, Miguel Garza, Ruayda Bouls, John Ronnau, Shawn P. Saladin, Aracely Ramirez

Research Colloquium

Purpose: Health professions students of the UTRGV AHEC Scholars Program sought to improve coordination of care and reduce barriers to care recommendations for patients of the UTHealthRGV AHEC clinics. We enacted a student-run multidisciplinary health care system navigation intervention, to address health disparities experienced by residents of colonias in the RGV.

Description: Health professions students voluntarily signed up to become “health care system navigators” (HCSNs) as part of a community-engagement activity sponsored by the AHEC Scholars Program. Students received informal training from AHEC staff in the use of the clinic EMR related to identifying patient contact information, documenting …

Pain Control, Cost Efficacy, And Patient Satisfaction Associated With Outpatient Total Ankle Arthroplasty, Myung-Jin Cha, Jennifer Adams

Research Colloquium

Introduction: There has been a drastic increase in the number of total ankle arthroplasty (TAA) procedures within the past twenty years. The trend for outpatient surgery is growing in the field of orthopaedics, and protocols now are well established for hip or knee arthroplasty. In this paper we review the recent developments in anesthesia for total ankle arthroplasty.

Methods: A comprehensive review of the current literature on the use of anesthesia in the context of outpatient total ankle arthroplasty was conducted. Search terms for PubMed included: Total ankle replacement surgery, TAA anesthesia, outpatient TAA, inpatient TAA.

Results: Preliminary results included …

A Case Of Lead-Induced Severe Tricuspid Regurgitation And Right-Sided Heart Failure, Elizabeth Akpan-Smart, Shyama Appareddy, Duc Khiem Ng, Michaela Q. Iglesia, Ayman Khaddam, Henry Kwang, Eduardo Flores

Research Colloquium

Background: Tricuspid regurgitation (TR) is a complication that can occur during defibrillator implantation procedures, particularly when the leads are placed in the right ventricle. TR is caused when the tricuspid valve does not close properly, causing blood to backflow to the right atrium during systole resulting in heart failure. The exact causes of TR after lead placement are not completely understood, but it is thought to be related to entrapment, impingement, perforation and adhesion of pacemaker leads. TR that develops from lead implantation has been associated with increased hospitalizations and decreased long-term survival. Our patient’s TR was multifactorial and …

It Is Not Pcp; It Is Cyclophosphamide Induced Toxicity, Mery Bartl, Yilen Karen Ng-Wong, Blesset Alexander, Josenny L. Rodriguez-Paez, Jose G. Gomez Casanovas, Christine Loftis, Andres Suarez Parraga

Research Colloquium

Background: Cyclophosphamide (CYC) is an immunosuppressive medication used to treat life threatening complications of various rheumatic diseases like vasculitis and systemic lupus erythematosus. 1% of patients on this medication develop pneumonitis. When considering CYC induced lung toxicity, other etiologies such as opportunistic infections and diffuse alveolar hemorrhage should be ruled out.

Case presentation: The patient is an 83-year-old woman with a past medical history of microscopic polyangiitis, and hypothyroidism who presented with progressive dyspnea at rest, exacerbated on exertion, associated with orthopnea. The patient was admitted due to acute on chronic hypoxemic respiratory failure with multifactorial etiology and heart failure …