Medicine and Health Sciences Commons^™

Exploring The Barriers And Supports Of Faith Community Nurses Serving In Alaska: A Qualitative Study, Nathan T. West, Phd, Lauren M. Kiker, Ba, Beverly R. Bateman, Msn, Rn, Fcn, Krista Jones, Dnp, Msn, Rn, Phna-Bc, Faan

International Journal of Faith Community Nursing

Decades of research exist on the public health impact of faith community nurses (FCNs), particularly congregational health promotion and disease prevention. However, the literature exploring the barriers and supports FCNs experience when serving their communities is limited. Thus, guided by Ziebarth’s (2016) conceptual framework of faith community nursing, this study explored the lived experiences of FCNs (N = 8) delivering care to faith communities in Alaska. Thematic analyses of qualitative data revealed three major themes including 1) the descriptions, characteristics, and roles performed by FCNs (e.g., active listening, policy-level recommendations); 2) barriers and other factors impacting FCNs’ delivery of care …

Is Semaglutide The Key To The Fight Against "Globesity"?, Melissa Travelsted, Maire M. Blankenship

International Journal of Faith Community Nursing

The obesity epidemic, referred to as "globesity" by the World Health Organization (WHO) in 2001, remains a critical global health issue with escalating prevalence rates. In 2022, approximately 2.5 billion adults worldwide were overweight, with 890 million classified as obese, highlighting a significant health burden and economic impact. By 2030, projections suggest over one billion individuals globally will be affected by obesity. In the United States, where more than 40% of adults are obese, healthcare costs attributed to obesity-related illnesses exceed $173 billion annually.

Obesity is defined by a body mass index (BMI) of 30 or above and significantly increases …

Unmeasured Confounding In Summary Estimates Of Maternal Periodontitis And Adverse Birth Outcomes: Meta-Analyses Of Observational Studies, May Salama, Abdullah Al-Taiar, Denise Mickenny

Graduate Student Government Association Research Conference

Abstract

Importance Maternal periodontitis has been consistently linked to adverse birth outcomes. However, a causal relationship is not established due to potential unmeasured confounding factors in observational studies and inconclusive results from randomized controlled trials.

Objective To assess the impact of unmeasured confounding factors in meta-analyses examining associations between maternal periodontal disease and preterm birth or low birth weight.

Data Sources PubMed/Medline, the Cochrane database for systematic reviews, Embase, Google Scholar, and a manual search of the reported references between 2002 and 2023.

Study Selection Systematic reviews with meta-analyses of observational studies were included if either preterm birth or low …

Investigating The Bidirectional Association Between Sociodemographic Predictors And Self-Reported Depression Among Adults In The United Arab Emirates, Mitha Abdallah Albalushi

Thesis/ Dissertation Defenses

Background: Globally, the prevalence of depression among adults is increasing, adversely affecting public health, daily functioning, and productivity. Epidemiological studies have established a strong correlation between depression and other risk factors. However, the aspects of this relationship have not been thoroughly explored in the United Arab Emirates (UAE). The aim of this study was to explore the association between self-perceived depression and other risk factors, such as sociodemographic characteristics, sleep duration, body mass index (BMI), and underlying chronic diseases such as diabetes and hypertension after adjustment for age and gender, among Emirati Adults. Methods: This cross-sectional study is part of …

Google Glass™ In Healthcare Education: A Scoping Review, David B. Gillette, Bhavana Raja

Pacific Journal of Health

Background: Google Glass™ (Glass), a wearable augmented reality device is gaining popularity in healthcare education due to its portability, affordability, and usefulness, including offering a different vantage point and potential for remote training. We conducted this scoping review to determine its applications, effectiveness, and limitations in healthcare education.

Methods: Seven electronic databases were searched for relevant studies and reports using specified search terms. Two reviewers independently screened studies for eligibility, retrieved data, and compared results.

Results: The search yielded 2,019 articles. After removing duplicates, 1,576 titles, 877 abstracts, and 408 articles were screened; 78 articles were included in this review. …

Exploration Of The Patient Experiences Of A University Lgbtq+ Community: A Preliminary Analysis, Joelle M. Kidder, Eric G. Waldon, Tracey Delnero, Michelle Brady, Kristine Himmerick, Deepti Vyas, Vienna Sa, Malinda Thao, Lindsay Gietzen

Pacific Journal of Health

PURPOSE: This qualitative study aimed to explore the lived experiences of people from a university LGBTQ+ community to inform health professional training in the interprofessional education setting.

METHODS:

Focus groups and semi-structured interviews from the University of the Pacific LGBTQ+ community were conducted by the researchers. Participants were recruited through campus-wide notification and fliers. Focus groups were held virtually on Zoom. Participants were asked to de-identify any identifying information. Informed consent and basic demographic information were obtained electronically. Participants were asked to reflect on personal experiences of their interactions within the healthcare system. The focus groups consisted of open-ended questions …

Cutaneous Adverse Effects From Diabetes Devices In Pediatric Patients With Type 1 Diabetes Mellitus: Systematic Review, Alicia Podwojniak, Joseph Flemming, Isabella J Tan, Hira Ghani, Zachary Neubauer, Anne Jones

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusions (CSIIs) are the current standard treatment devices for type 1 diabetes (T1D) management. With a high prevalence of T1D beginning in pediatrics and carrying into adulthood, insufficient glycemic control leads to poor patient outcomes. Dermatologic complications such as contact dermatitis, lipodystrophies, and inflammatory lesions are among those associated with CGM and CSII, which reduce glycemic control and patient compliance.

OBJECTIVE: This systematic review aims to explore the current literature surrounding dermatologic complications of CGM and CSII as well as the impact on patient outcomes.

METHODS: A systematic review of the …

A Protocol For Immunostaining Of Macrophages In Whole-Mount Mouse Cornea, Conjunctiva, And Lacrimal Gland, Saleh Alfuraih, Dhruv Patel, Wonsuk Choi, Karthikeyan Ramasamy, Rais Ansari, Ajay Sharma

Pharmacy Faculty Articles and Research

The healthy lacrimal functional unit contains a resident macrophage population. Here, we present a protocol for immunofluorescent staining of macrophage markers, CD11b, F4/80, and CD206, in whole-mount mouse cornea, conjunctiva, and 50-μM-thick lacrimal gland section. We describe steps for dissection, fixation, permeabilization, and blocking. We then detail procedures for the detection and spatial localization of macrophages through immunostaining and confocal imaging. This approach circumvents the need to obtain thin tissue sections and acquire macrophage images from each tissue section.

Executive Summary: Quality Improvement Initiative Personalized Interdisciplinary Fall Prevention Plan And Fall Rates At An Inpatient Rehabilitation Hospital, Kayla Jackson

Walden Dissertations and Doctoral Studies

Despite ongoing fall prevention strategies, falls continue to be a concern across healthcare organizations. There has been an identified increase in the fall rate at an inpatient rehabilitation facility (IRF) in the southeastern United States. An interprofessional and collaborative approach to fall prevention has been found to lead to a decrease in falls with injury and an increase in the culture of safety. This doctor of nursing practice (DNP) project involved an evaluation of a quality improvement (QI) initiative of a personalized interdisciplinary fall prevention plan at a rehabilitation hospital located in the southeastern region of the United States. The …

Identification And Treatment Of Ipv/Nonfatal Strangulation By First Responders, Mary L. Turner

Walden Dissertations and Doctoral Studies

Ineffective and inconsistent education focusing on domestic violence (DV)/intimate partner violence (IPV)/nonfatal strangulation identification and treatments results in first responders’ failure to move patients to a higher level of care, resulting in possible delayed complications. The purpose of the Doctor of Nursing practice (DNP) project was to determine if an educational program increased first responders’ knowledge and improved treatment of DV/IPV/nonfatal strangulation patients. Roger’s diffusion of innovation theory provided the framework throughout the educational process. The Physician Readiness to Manage Intimate Partner Violence Survey (PREMIS) tool was utilized to score the participants’ knowledge prior to and after the education. The …

Socioecological Factors Influencing The Anticipated Medical Help-Seeking Time For Breast Cancer Among Women In Togo, A Sub-Saharan Country, Komi Blewussi Aheto

Walden Dissertations and Doctoral Studies

Breast cancer remains a leading cause of death in sub-Saharan Africa (SSA). The burden of the disease in the region is partly attributed to delayed health-seeking, resulting in advanced disease presentation, delayed diagnosis, poor outcomes, and low survival. This quantitative cross-sectional study was conducted to investigate the socioecological factors that influence the anticipated medical health-seeking time for women in SSA experiencing breast cancer symptoms. The socioecological model (SEM) theoretical framework guided this study. A questionnaire was used to collect data from randomly selected (N = 343) women aged 18 years and older with no personal or familial history of breast …

Comparing Fermented Food And Vitamin E On Exercise-Mediated Nrf2/Are Activation In Middle-Aged/ Elderly: A Randomized, Double-Blind Clinical Study, Joseph Cervi, Reza Rastmanesh, Amir Moghadam-Ahmadi, Antonio Ayala, Cristiana Aperio, Aldo Lorenzetti, Maki Osato, Francesco Marotta, Antonio Nardin, Fang He

Department of Neuroscience Faculty Papers

Background: There is a compelling need to emphasize the importance of deepening the rationale behind functional foods research in molecular biology. Indeed, establishing stringent criteria to evaluate functional food interventions in disease prevention and as adjunctive therapeutic strategies offers significant opportunities for health promotion. Objective: This study investigated the effects of fermented papaya preparation (FPP®) and vitamin E on gene expression in middle-aged/elderly individuals, leveraging FPP’s established antioxidant and immune-regulatory benefits. Methods: Graded Exercise Walking Test was administered twice weekly for 6 months. Total Antioxidant capacity (TAC) and gene expression (Nrf2, NQO1, HO-1) in PBMC were measured monthly. Results: Throughout …

Determinants Of Salary Variation And The Gender Pay Gap: A Survey Of The American Association Of Hip And Knee Surgeons (Aahks) Surgeon Member Workforce, Prem N. Ramkumar, Jenna A. Bernstein, David C. Landy, David E. Demik, Justin T. Deen, Reena J. Olsen, Anna Cohen-Rosenblum

School of Medicine Faculty Publications

Background: The increased emphasis on reimbursement, diversity, and burnout in hip and knee arthroplasty necessitates a foundational understanding of the surgeon workforce. The purpose of the study was to cross sectionally survey a representative sample of the AAHKS surgeon membership on the subject of salary, practice patterns, and demographic factors to establish a baseline framework for future advocacy efforts and initiatives. Methods: An online survey was sent to AAHKS members between December 20, 2022 and January 19, 2023. Surgeon demographic data, experience, practice geography and type, and annual case volume were solicited. Univariate and multivariate analyses were performed to describe …

Bridging Public Health Research And State-Level Policy: The Texas Research-To-Policy Collaboration Project., Deanna M Hoelscher, Alexandra Van Den Berg, Amelia Roebuck, Shelby Flores-Thorpe, Kathleen Manuel, Tiffni Menendez, Christine Jovanovic, Aliya Hussaini, John T Menchaca, Elizabeth Long, D Max Crowley, J Taylor Scott

Health Services and Informatics Research

PURPOSE AND OBJECTIVES: Significant barriers to the implementation of evidence-based policy exist. Establishing an infrastructure and resources to support this process at the state level can accelerate the translation of research into practice. This study describes the adaptation and initial evaluation of the Texas Research-to-Policy Collaboration (TX RPC) Project, focusing on the adaptation process, legislative public health policy priorities, and baseline researcher policy knowledge and self-efficacy.

INTERVENTION APPROACH: The federal Research-to-Policy Collaboration (RPC) method was adapted to the Texas legislative process in 2020. Policymakers and public health researchers were recruited using direct outreach and referrals. Legislators or their aides were …

Commentary: Obstructive Sleep Apnea In The Hemodialysis Population: Are Clinicians Putting Existing Scientific Evidence Into Practice?, Aleena Jamal, Som Singh, Fawad Qureshi

SKMC Student Presentations and Publications

No abstract provided.

Endovascular Treatment Of Patients With Acute Ischemic Stroke With Tandem Lesions Presenting With Low Alberta Stroke Program Early Computed Tomography Score, Milagros Galecio-Castillo, Mudassir Farooqui, Waldo R. Guerrero, Marc Ribo, Ameer E. Hassan, Mouhammad A. Jumaa, Afshin A. Divani, Michael G. Abraham, Nils Petersen, Johanna T. Fifi

School of Medicine Publications

Background: Recent trials confirmed the efficacy and safety of endovascular thrombectomy in patients with low Alberta Stroke Program Early Computed Tomography Score (ASPECTS); however, evidence in tandem lesions is limited. This study evaluates endovascular thrombectomy safety and efficacy in patients with acute large-vessel occlusion with tandem lesions, stratified by baseline ASPECTS.

Methods and results: We conducted a retrospective analysis of data from 16 centers. Inclusion criteria included the following: age ≥18 years, anterior circulation tandem lesions, endovascular thrombectomy onset, and ≥70% internal carotid artery stenosis/occlusion. Patients were categorized into low (0-5) and high (6-10) ASPECTS. Inverse probability of treatment weighting …

Educating Mental Healthcare Staff On Using The Phq-9 In Telehealth, Anoopa M. Jacob

Walden Dissertations and Doctoral Studies

I developed a quality improvement staff educational program aimed at addressing the inconsistent use of the Patient Health Questionnaire (PHQ-9) at the project facility, which could adversely affect the quality and continuity of patient care. The need for the program was prompted by the increasing use of telehealth services and the necessity for consistent mental health evaluation tools. I aimed to educate mental health staff about evidence-based practices using the PHQ-9 in telehealth to enhance the quality of care for patients with depression in remote settings. Analytical methods included administering pre- and postintervention tests to measure changes in staff knowledge …

Nanobubble Contrast Enhanced Ultrasound Imaging: A Review, Pinunta Nittayacharn, Felipe M. Berg, Dorian Durig, Agata A. Exner

Faculty Scholarship

Contrast-enhanced ultrasound is currently used worldwide with clinical indications in cardiology and radiology, and it continues to evolve and develop through innovative technological advancements. Clinically utilized contrast agents for ultrasound consist of hydrophobic gas microbubbles stabilized with a biocompatible shell. These agents are used commonly in echocardiography, with emerging applications in cancer diagnosis and therapy. Microbubbles are a blood pool agent with diameters between 1 and 10 μm, which precludes their use in other extravascular applications. To expand the potential use of contrast-enhanced ultrasound beyond intravascular applications, sub-micron agents, often called nanobubbles or ultra-fine bubbles, have recently emerged as a …

Executive Summary: Quality Improvement Initiative Implementing Fixed Water Dispensers In An Inpatient Psychiatric Hospital, Elycia Victoria Hernandez

Walden Dissertations and Doctoral Studies

The current hydration system using water pitchers was outdated and inefficient, leading to potential risks of contamination, inconsistent hydration, and increased staff workload in this inpatient psychiatric facility. Psychiatric patients may struggle to access adequate hydration due to cognitive or behavioral limitations. Addressing this gap is essential for improving patient care, enhancing operational efficiency, and ensuring consistent access to clean water. This DNP scholarly project was an evaluation of an interprofessional team-based quality initiative to replace traditional water pitchers with fixed water dispensers in an acute inpatient psychiatric facility. The primary practice-focused question was: Will an interprofessional team reach consensus …

Brain Metastases In Sarcomas: A Multicenter Retrospective Cohort Study, Ellen Zhang, Sheima Farag, Hilary Dietz, Daniel Wang, Angela Hirbe, Kristen Ganjoo, Brian Van Tine, Shane Zaid, Aisha Miah, Vicki Keedy, Elizabeth Davis, Nam Bui

Faculty, Staff and Students Publications

Purpose: Brain metastases (BM) in sarcomas occur rarely and are associated with poor prognosis. This study is a large retrospective cohort describing the demographic and clinical characteristics of these patients, treatment strategies, and survival outcomes.

Methods: In total, 81 patients with BM from sarcomas were identified across five sarcoma centers. Demographic data, clinical presentation, and treatment modalities were analyzed.

Results: The most common histologies were leiomyosarcoma (12.3%) and undifferentiated pleomorphic sarcoma (12.3%). The median time from sarcoma diagnosis to brain metastases was 1.9 years. Upon presentation, 88.9% of patients with BM from sarcomas were symptomatic with the most common presenting …

Homozygous Variants In Wdr83os Lead To A Neurodevelopmental Disorder With Hypercholanemia, Scott Barish, Sheng-Jia Lin, Reza Maroofian, Alper Gezdirici, Hamoud Alhebby, Aurélien Trimouille, Marta Biderman Waberski, Tadahiro Mitani, Ilka Huber, Kristian Tveten, Øystein L Holla, Øyvind L Busk, Henry Houlden, Ehsan Ghayoor Karimiani, Mehran Beiraghi Toosi, Reza Shervin Badv, Paria Najarzadeh Torbati, Fatemeh Eghbal, Javad Akhondian, Ayat Al Safar, Abdulrahman Alswaid, Giovanni Zifarelli, Peter Bauer, Dana Marafi, Jawid M Fatih, Kevin Huang, Cassidy Petree, Daniel G Calame, Charlotte Von Der Lippe, Fowzan S Alkuraya, Sami Wali, James R Lupski, Gaurav K Varshney, Jennifer E Posey, Davut Pehlivan

Faculty, Staff and Students Publications

WD repeat domain 83 opposite strand (WDR83OS) encodes the 106-aa (amino acid) protein Asterix, which heterodimerizes with CCDC47 to form the PAT (protein associated with ER translocon) complex. This complex functions as a chaperone for large proteins containing transmembrane domains to ensure proper folding. Until recently, little was known about the role of WDR83OS or CCDC47 in human disease traits. However, biallelic variants in CCDC47 were identified in four unrelated families with trichohepatoneurodevelopmental syndrome, characterized by a neurodevelopmental disorder (NDD) with liver dysfunction. Three affected siblings in an additional family share a homozygous truncating WDR83OS variant and a phenotype of …

Total Retinal Thickness Is An Important Factor In Evaluating Diabetic Retinal Neurodegeneration, Noor-Us-Sabah Ahmad, Kristen Staggers, Kyungmoo Lee, Nitish Mehta, Amitha Domalpally, Benjamin J Frankfort, Yao Liu, Roomasa Channa

Faculty, Staff and Students Publications

OBJECTIVE: Macular retinal nerve fibre layer (mRNFL) and ganglion cell-inner plexiform layer thickness (GC-IPL) measurements are important markers of diabetic retinal neurodegeneration (DRN). In this cross-sectional study, we aimed to quantify the contribution of total retinal thickness (TRT) and other factors in the variation of mRNFL and GC-IPL thickness among participants with diabetes.

METHODS AND ANALYSIS: We used macular-centred spectral domain-optical coherence tomography scans from participants with diabetes in the UK Biobank. Two multiple linear regression models (prior to and after adjusting for TRT) were used to determine factors associated with mRNFL and GC-IPL thicknesses. A p value of less …

Large-Scale Application Of Clingen-Insight Apc-Specific Acmg/Amp Variant Classification Criteria Leads To Substantial Reduction In Vus, Xiaoyu Yin, Marcy Richardson, Andreas Laner, Xuemei Shi, Elisabet Ognedal, Valeria Vasta, Thomas V O Hansen, Marta Pineda, Deborah Ritter, Johan De Dunnen, Emadeldin Hassanin, Wencong Lyman Lin, Ester Borras, Karl Krahn, Margareta Nordling, Alexandra Martins, Khalid Mahmood, Emily Nadeau, Victoria Beshay, Carli Tops, Maurizio Genuardi, Tina Pesaran, Ian M Frayling, Gabriel Capellá, Andrew Latchford, Sean V Tavtigian, Carlo Maj, Sharon E Plon, Marc S Greenblatt, Finlay A Macrae, Isabel Spier, Stefan Aretz

Faculty, Staff and Students Publications

Pathogenic constitutional APC variants underlie familial adenomatous polyposis, the most common hereditary gastrointestinal polyposis syndrome. To improve variant classification and resolve the interpretative challenges of variants of uncertain significance (VUSs), APC-specific variant classification criteria were developed by the ClinGen-InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel (VCEP) based on the criteria of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP). A streamlined algorithm using the APC-specific criteria was developed and applied to assess all APC variants in ClinVar and the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) international reference APC Leiden Open Variation …

Metallomic Approach To Mercury And Selenium In The Liver Tissue Of Psectrogaster Amazonica And Raphiodon Vulpinus From The Brazilian Amazon, Izabela Bataglioli, José Vieira, Joyce Da Siva, Luane Andrade, Victor Faria, Rebeca Corcoba, Ronaldo De Almeida, Luiz Zara, Marília Buzalaf, Jiri Adamec, Pedro Padilha

School of Medicine Faculty Publications

This paper reports the results of a mercury (Hg) and selenium (Se) metallomic study in the liver tissues of Psectrogaster amazonica and Raphiodon vulpinus from the Brazilian Amazon. Two-dimensional electrophoresis, graphite furnace atomic absorption spectrometry, and liquid chromatography-tandem mass spectrometry were performed. Hg and Se determinations allowed the calculation of Hg:Se and Se:Hg molar ratio and Se values for health benefits (Se HBVs). The Se:Hg values were >1 for both fish species, whereas the Se HBVs were >5 for P. amazonica and >10 for R. vulpinus, indicating that both possess Se reserves to control Hg toxicity. The metallomic data allowed …

Addressing Practice Effects In Population-Based Studies Of Trends In Late-Life Dementia And Cognitive Impairment, Vicki A Freedman, Mengyao Hu

Faculty, Staff and Student Publications

No abstract provided.

Staff Education To Enhance Nurses’ Knowledge In Managing Alcohol Withdrawal, Nodeen Nicoal Glen

Walden Dissertations and Doctoral Studies

Summary Summary This DNP clinical practice staff education was developed to address the lack of nursing knowledge, and skills needed to assess and manage alcohol withdrawal effectively in an observation unit. Ineffective assessment and management of patients’ withdrawal symptoms may result in deterioration of their condition and require further aggressive treatment. The project aimed to educate nurses on evidence-based strategies for assessing and managing alcohol withdrawal using an evidence-based assessment tool. Sixteen nurses participated in the program to increase their understanding of alcohol withdrawal and the use of the Richmond Agitation-Sedation Scale (RASS). They completed a pretest before participating in …

Real-World Impact Of Differences In The Who And Icc Classifications Of Non-Hodgkin Lymphoma: A Leo Cohort Study Analysis, Brooj Abro, Matthew J Maurer, Thomas M Habermann, W Richard Burack, Jennifer R Chapman, Jonathon B Cohen, Jonathan W Friedberg, Giorgio Inghirami, Brad S Kahl, Melissa C Larson, Brian K Link, Izidore S Lossos, Peter Martin, Timothy J Mcdonnell, Loretta J Nastoupil, Shaun M Riska, Sergei Syrbu, Francisco Vega, Kiran R Vij, Christopher R Flowers, James R Cerhan, David L Jaye, Andrew L Feldman

Faculty, Staff and Student Publications

Recent introduction of 2 different lymphoma classifications has raised concerns about consistency in diagnosis, management, and clinical trial enrollment. Data from a large cohort reflecting real-world clinical practice suggest that differences between the classifications will affect < 1% of non-Hodgkin lymphomas.

Estimating The Number Of Polygenic Diseases Among Six Mutually Exclusive Entities Of Non-Tumors And Cancer, C I Edvard Smith, Jan A Burger, Rula Zain

Faculty, Staff and Student Publications

In the era of precision medicine with increasing amounts of sequenced cancer and non-cancer genomes of different ancestries, we here enumerate the resulting polygenic disease entities. Based on the cell number status, we first identified six fundamental types of polygenic illnesses, five of which are non-cancerous. Like complex, non-tumor disorders, neoplasms normally carry alterations in multiple genes, including in 'Drivers' and 'Passengers'. However, tumors also lack certain genetic alterations/epigenetic changes, recently named 'Goners', which are toxic for the neoplasm and potentially constitute therapeutic targets. Drivers are considered essential for malignant transformation, whereas environmental influences vary considerably among both types of …

Probabilistic Presurgical Language Fmri Atlas Of Patients With Brain Tumors, Jian Ming Teo, Vinodh A Kumar, Jina Lee, Rami W Eldaya, Ping Hou, Mu-Lan Jen, Kyle R Noll, Peng Wei, Sherise D Ferguson, Sujit S Prabhu, Max Wintermark, Ho-Ling Liu

Faculty, Staff and Student Publications

Background and purpose: Patients with brain tumors have high intersubject variation in putative language regions, which may limit the utility of straightforward application of healthy subject brain atlases in clinical scenarios. The purpose of this study was to develop a probabilistic functional brain atlas that consolidates language functional activations of sentence completion and Silent Word Generation language paradigms using a large sample of patients with brain tumors.

Materials and methods: The atlas was developed using retrospectively collected fMRI data from patients with brain tumors who underwent their first standard-of-care presurgical language fMRI scan at our institution between July 18, 2015, …

Identification Of Atypical Pediatric Diabetes Mellitus Cases Using Electronic Medical Records, Marcela F Astudillo, William E Winter, Liana K Billings, Raymond Kreienkamp, Ashok Balasubramanyam, Maria J Redondo, Mustafa Tosur

Faculty, Staff and Students Publications

INTRODUCTION: There are no established methods to identify children with atypical diabetes for further study. We aimed to develop strategies to systematically ascertain cases of atypical pediatric diabetes using electronic medical records (EMR).

RESEARCH DESIGN AND METHODS: We tested two strategies in a large pediatric hospital in the USA. Strategy 1: we designed a questionnaire to rule out typical diabetes and applied it to the EMR of 100 youth with diabetes. Strategy 2: we built three electronic queries to generate reports of three atypical pediatric diabetes phenotypes: unknown type, type 2 diabetes (T2D) diagnosed(AbNegT1D).

RESULTS: Strategy 1 identified six cases …