Medicine and Health Sciences Commons^™

Endovascular Removal Of A Symptomatic Intracranial Foreign Body Via Contact Aspiration: Illustrative Case, Jared M. Robichaux, Sarah E. Lawhon, Taylor W. Girolamo, Kapland Q. Owens, Lucido L. Ponce Mejia

School of Medicine Faculty Publications

BACKGROUND: With the growing utilization of general endovascular techniques, iatrogenic endovascular foreign bodies have become more prevalent. Contact aspiration has proven to be a valuable technique in treating ischemic strokes by removing the intraluminal thrombus causing cerebral perfusion deficits and neurological symptoms. The authors present a case of the removal of a foreign body from the vasculature via contact aspiration, which had embolized in a delayed fashion after aortic valve replacement. OBSERVATIONS: A 54-year-old male developed intermittent left-sided weakness 8 days after aortic valve replacement. A head computed tomography scan showed a metallic foreign body within the origin of the …

Natural Language Processing For Precise Identification Of Primary Tumor Histology And Radiation Necrosis In Stereotactic Radiosurgery Patients, Mario Fugal

MUSC Theses and Dissertations

The management of brain metastases and their associated complications, such as radiation necrosis, has long posed significant challenges in radiation oncology. Stereotactic radiosurgery (SRS) is a key treatment modality for patients with brain metastases, yet the complexity of metastatic disease and limitations in diagnostic coding systems, such as the International Classification of Diseases (ICD), often obstruct the accurate extraction of critical information from electronic health records (EHRs). This difficulty especially impacts the identification of primary tumor histology and the detection of post-treatment complications like radiation necrosis (RN), both of which are crucial for improving clinical outcomes and conducting robust observational …

11.18.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Director of Research Lab Safety

GIS Day

Tech Startup Weekend

NSF Virtual Grants Conference

Interprofessional Approach To Anxiety And Depression, John M. Sedrak, Benjamin Jones, Dominique Denbow, Ezra Aistrop-Gormley

CAIEP Fall Showcase 2024

A multidisciplinary approach for treating a patient from El Paso, Texas, with complex social and psychiatric challenges, including comorbid depression and anxiety. She faces limited access to resources, a sparse support system, and escalating social barriers. Environmental stressors, such as traffic pollution that exacerbates her asthma, and minimal community engagement further impact her mental health. An interprofessional care plan included mental health counseling, community outreach to enhance social support, and medical management to comprehensively address her interconnected health needs.

Hpv In Men: Prevalence, Transmission Dynamics, And Health Implications, Gia Citrino

Student Papers, Posters & Projects

Human Papilloma Virus (HPV) is a culmination of over 200 known viruses. Most of these strains of viruses do not have any negative effect on humans. There are a handful of known strains that are high-risk and if infected, could lead to common warts, genital warts, or even cancer. Human Papilloma Virus effects both men and women but research has a focus on women. In 2019, HPV caused an estimated 620,000 cancer cases in women and 70,000 cancer cases in men (WHO, 2024). There are many ways to protect oneself from infection, for example, limiting sexual partners, using protection such …

The Southern Nevada Care Economy: Challenges And Opportunities, Tripp Umbach

Policy Briefs and Reports

National policymakers increasingly recognize the care economy as an essential economic driver, contributing $648 billion annually to the U.S. economy and supporting 3.6 million jobs. The care economy is also critical in driving economic development and prosperity in Southern Nevada. Yet, as this Tripp Umbach analysis finds, Southern Nevada’s care economy dramatically underperforms compared to national benchmarks and peer regions. High caregiving costs and limited access to care for children, seniors, and individuals with disabilities in Southern Nevada strain families, businesses, and public resources. This burden reduces workforce participation, productivity, and economic growth. Low pay and high turnover among care …

Clinical Practice Guidelines For Fall Prevention In The Neurology Unit, Jorge Martin Fernandez

Walden Dissertations and Doctoral Studies

This clinical practice guideline (CPG) initiative addressed the rising patient fall rates at an inpatient general care neurology unit (GCNU) in North Carolina. Falls are a leading cause of preventable injury, yet the facility lacked evidence-based (EB) fall prevention practices. This doctoral project developed a CPG for GCNU fall prevention, which was evaluated by an expert panel using the AGREE II instrument. A literature review identified 20 studies assessed via the Johns Hopkins model, which informed the CPG. Expert review scored the CPG at 100% in all domains, leading to its approval for clinical use. Key recommendations include CPG expansion, …

Association Of Binge Alcohol Use With Functional Outcomes Among Individuals With Covid-19 Infection, Sebastian T. Tong, Michael Gottlieb, Imtiaz Ebna Mannan, Zihan Zheng, Manisha Sinha, Michelle Santangelo, Kristyn Gatling, Efrat Kean, Phillip Watts, Ralph Wang, Juan Carlos Montoy, Ahamed Idris, Samuel Macdonald, Ryan Huebinger, Mandy Hill, Kelli N O'Laughlin, Nicole L. Gentile, Jocelyn Dorney, Caitlin Malicki, Joann G. Elmore, Kate Diaz Roldan, Gary Chan, Zhenqiu Lin, Robert A. Weinstein, Kari A. Stephens

Department of Medicine Faculty Papers

AIMS: Alcohol consumption along with negative sequelae from excess alcohol intake increased during the COVID-19 pandemic. We evaluated the association between binge alcohol use and long-term functional outcomes among COVID-19-positive individuals.

METHODS: Using a prospective, longitudinal, multisite cohort study design, we evaluated the association between binge alcohol use and mental and physical functional outcomes using Patient-Reported Outcomes Measurement Information System (PROMIS)-29 scores three and six months postinfection. Eligible patients were those who presented with COVID-19-like symptoms, tested positive for COVID-19, and completed a three-month survey. Binge drinking was identified at the time of infection using the Tobacco, Alcohol, Prescription medication …

Clarification Regarding The Psychiatrist's Role: Psychiatric Care Versus Psychosocial Support-Reply To Akerson Et Al, Sindhura Vangala, Roy Williams Jr, Cara M Buskmiller, Jessian L Munoz

Faculty, Staff and Students Publications

No abstract provided.

Tumor-Associated Antigen Prediction Using A Single-Sample Gene Expression State Inference Algorithm, Xinpei Yi, Hongwei Zhao, Shunjie Hu, Liangqing Dong, Yongchao Dou, Jing Li, Qiang Gao, Bing Zhang

Faculty, Staff and Students Publications

We developed a Bayesian-based algorithm to infer gene expression states in individual samples and incorporated it into a workflow to identify tumor-associated antigens (TAAs) across 33 cancer types using RNA sequencing (RNA-seq) data from the Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA). Our analysis identified 212 candidate TAAs, with 78 validated in independent RNA-seq datasets spanning seven cancer types. Eighteen of these TAAs were further corroborated by proteomics data, including 10 linked to liver cancer. We predicted that 38 peptides derived from these 10 TAAs would bind strongly to HLA-A02, the most common HLA allele. Experimental validation confirmed …

Life History Of Men Who Experienced Childhood Maternal Absence, Renice Obure

USF Tampa Graduate Theses and Dissertations

This dissertation project explored the impact of childhood maternal absence on the life history outcomes of adult men. An integrated theoretical model of developmental-evolutionary framework was developed to guide research design and conduct. This model combined sex-differentiated life history framework and fathering resource theory. The study consisted of three components: a scoping review of 29 relevant studies conducted in the United States between 1990-2023, a quantitative analysis of the National Longitudinal Study of Adolescent and Adult Health (Add Health) waves I and IV (n=6932), and a qualitative analysis of in-depth interviews with a sample of 22 fathers who experienced childhood …

Camkk2: Bridging The Gap Between Ca2+ Signaling And Energy-Sensing, Luke M Mcaloon, Abbey G Muller, Kevin Nay, Eudora L Lu, Benoit Smeuninx, Anthony R Means, Mark A Febbraio, John W Scott

Faculty, Staff and Students Publications

Calcium (Ca2+) ions are ubiquitous and indispensable signaling messengers that regulate virtually every cell function. The unique ability of Ca2+ to regulate so many different processes yet cause stimulus specific changes in cell function requires sensing and decoding of Ca2+ signals. Ca2+-sensing proteins, such as calmodulin, decode Ca2+ signals by binding and modifying the function of a diverse range of effector proteins. These effectors include the Ca2+-calmodulin dependent protein kinase kinase-2 (CaMKK2) enzyme, which is the core component of a signaling cascade that plays a key role in important physiological and pathophysiological processes, including brain function and cancer. In addition …

The Pipeline Embolization Device For The Treatment Of Intracranial Aneurysms In Pediatric Patients With Tuberous Sclerosis Complex: Illustrative Cases, Eveline Teresa Hidalgo, Eric A Grin, Omar Tanweer, Cordelia Orillac, Jason K Chu, Peter Kan, Howard L Weiner

Faculty, Staff and Students Publications

BACKGROUND: Tuberous sclerosis complex (TSC) is a neurocutaneous disorder characterized by the multisystem development of benign tumors. Patients with TSC are also at an increased risk of developing intracranial aneurysms early in life. While aneurysms have historically been treated with open surgical clipping, endovascular approaches are increasingly being used in both pediatric and adult populations.

OBSERVATIONS: In this case series, the authors report the endovascular treatment of three young patients with TSC and fusiform intracranial aneurysms using the Pipeline embolization device (PED) for flow diversion of the affected artery. In all cases, complete aneurysm occlusion was observed, with good parent …

Leptin Levels Are Associated With Coronary Artery Calcification In Patients With Advanced Prostate Cancer, Efstratios Koutroumpakis, Neha Venkatesh, Ana Aparicio, Juhee Song, Theocharis Panaretakis, Anita Deswal, Christopher J Logothetis, Daniel E Frigo, Andrew W Hahn

Faculty, Staff and Student Publications

Background: Convergent data suggest that advanced prostate cancer and coronary heart disease (CHD) share biological vulnerabilities that may be linked to adiposity. Here we explore whether leptin, as a marker and mediator of adiposity, could link prostate cancer to CHD.

Methods: Patients with metastatic castration-resistant prostate cancer (mCRPC) enrolled in a phase II trial (NCT02703623) studying androgen deprivation therapy, abiraterone, prednisone, and apalutamide were eligible if they had plasma and a chest CT scan available. Coronary artery calcium (CAC) scores and adipokine levels were measured upon enrollment.

Results: Of 164 patients, 87% were white. The mean age was …

Genomic And Transcriptomic Analyses Identify Distinctive Features Of Triple-Negative Inflammatory Breast Cancer, Xiaoping Wang, Li Zhao, Xingzhi Song, Xiaogang Wu, Savitri Krishnamurthy, Takashi Semba, Shan Shao, Mark Knafl, Larry W Coffer, Angela Alexander, Anita Vines, Swetha Bopparaju, Wendy A Woodward, Randy Chu, Jianhua Zhang, Clinton Yam, Lenora W M Loo, Azadeh Nasrazadani, Le-Petross Huong, Scott E Woodman, Andrew Futreal, Debu Tripathy, Naoto T Ueno

Faculty, Staff and Student Publications

Triple-negative inflammatory breast cancer (TN-IBC) is the most aggressive type of breast cancer, yet its defining genomic, molecular, and immunological features remain largely unknown. In this study, we performed the largest and most comprehensive genomic and transcriptomic analyses of prospectively collected TN-IBC patient samples from a phase II clinical trial (ClinicalTrials.gov, NCT02876107, registered on August 22, 2016) and compared them to similarly analyzed stage III TN-non-IBC patient samples (ClinicalTrials.gov, NCT02276443, registered on October 21, 2014). We found that TN-IBC tumors have distinctive genomic, molecular, and immunological characteristics, including a lower tumor mutation load than TN-non-IBC, and an association …

Long-Term Outcomes Following Posterior Fossa Decompression In Pediatric Patients With Chiari Malformation Type 1, A Population-Based Cohort Study, Victor Gabriel El-Hajj, Erik Öhlén, Ulrika Sandvik, Jenny Pettersson-Segerlind, Elias Atallah, Pascal Jabbour, Mohamad Bydon, David J. Daniels, Adrian Elmi-Terander, Erik Edström

Department of Neurosurgery Faculty Papers

OBJECTIVE: Posterior fossa decompression for Chiari malformation type I (Chiari 1) is effective and associated with a low risk of complication. However, up to 20% of patients may experience continued deficits or recurring symptoms after surgical intervention. For pediatric patients, there are no established tools to predict outcomes, and the risk factors for unfavorable postoperative outcomes are poorly understood. Hence, our aim was to investigate baseline data and early postoperative predictors of poor outcomes as determined by the Chicago Chiari outcome scale (CCOS).

METHODS: All pediatric patients (< 18 years) receiving a posterior fossa decompression for Chiari 1 between the years of 2005 and 2020 at the study center were eligible for inclusion. Patients with congenital anomalies were excluded.

RESULTS: Seventy-one pediatric patients with a median age of 9 years were …

Consensus Definition Of A Radiologically Healed Fistula On Magnetic Resonance Imaging In Perianal Crohn's Disease: An International Delphi Study, Easan Anand, Jalpa Devi, Shivani Joshi, Anna Antoniou, Michelle Doering, Jaap Stoker, Phillip Lung, Ailsa L Hart, David H Ballard, Parakkal Deepak, Phil Tozer

2020-Current year OA Pubs

INTRODUCTION: Perianal fistulising Crohn's disease (pfCD) is a distinct and debilitating phenotype seen in around one-third of patients with CD. Clinical trials in pfCD are increasingly using magnetic resonance imaging (MRI) criteria as a primary endpoint, but there is heterogeneity in the radiological definition of a healed perianal fistula that currently limits our ability to perform meaningful meta-analyses of studies. Our aim is to standardise outcomes through the generation of an international consensus definition of a radiologically healed fistula.

METHODS AND ANALYSIS: This international Delphi consensus study employs a two-part strategy.The first is a systematic review to identify a longlist …

Circulating Blood Circular Rna In Parkinson's Disease; From Involvement In Pathology To Diagnostic Tools In At-Risk Individuals, Aleksandra Beric, Yichen Sun, Santiago Sanchez, Charissa Martin, Tyler Powell, Ravindra Kumar, Jose Adrian Pardo, Gauri Darekar, Jessie Sanford, Devin Dikec, Bridget Phillips, Juan A Botia, Carlos Cruchaga, Laura Ibanez

2020-Current year OA Pubs

To identify circRNAs associated with Parkinson's disease (PD) we leveraged two of the largest publicly available studies with longitudinal clinical and blood transcriptomic data. We performed a cross-sectional study utilizing the last visit of each participant (N = 1848), and a longitudinal analysis that included 1166 participants with at least two time points. We identified 192 differentially expressed circRNAs, with effects that were sustained during disease, in mutation carriers, and diverse ancestry. The 192 circRNAs were leveraged to distinguish between PD and healthy participants with a ROC AUC of 0.797. Further, 71 circRNAs were sufficient to distinguish between genetic PD …

Comparative Neurofilament Light Chain Trajectories In Csf And Plasma In Autosomal Dominant Alzheimer's Disease, Anna Hofmann, Jorge J Llibre-Guerra, Richard J Perrin, Laura Ibanez, Randall J Bateman, Eric Mcdade, Brian A Gordon, Et Al.

2020-Current year OA Pubs

Disease-modifying therapies for Alzheimer's disease (AD) are likely to be most beneficial when initiated in the presymptomatic phase. To track the benefit of such interventions, fluid biomarkers are of great importance, with neurofilament light chain protein (NfL) showing promise for monitoring neurodegeneration and predicting cognitive outcomes. Here, we update and complement previous findings from the Dominantly Inherited Alzheimer Network Observational Study by using matched cross-sectional and longitudinal cerebrospinal fluid (CSF) and plasma samples from 567 individuals, allowing timely comparative analyses of CSF and blood trajectories across the entire disease spectrum. CSF and plasma trajectories were similar at presymptomatic stages, discriminating …

Reconstitution Of Arp2/3-Nucleated Actin Assembly With Proteins Cp, V-1, And Carmil, Olivia L Mooren, Patrick Mcconnell, James D Debrecht, Anshuman Jaysingh, John A Cooper

2020-Current year OA Pubs

Actin polymerization is often associated with membrane proteins containing capping-protein-interacting (CPI) motifs, such as capping protein, Arp2/3, myosin I linker (CARMIL), CD2AP, and WASHCAP/Fam21. CPI motifs bind directly to actin-capping protein (CP), and this interaction weakens the binding of CP to barbed ends of actin filaments, lessening the ability of CP to functionally cap those ends. The protein V-1/myotrophin binds to the F-actin-binding site on CP and sterically blocks CP from binding barbed ends. CPI-motif proteins also weaken the binding between V-1 and CP, which decreases the inhibitory effects of V-1, thereby freeing CP to cap barbed ends. Here, we …

Nature Healing Mental Stress: What U.S. Healthcare Can Learn From Other Nations, Shannon Frank-Richter, Lindsay Gietzen

Pacific Journal of Health

The United States healthcare system lags many developed nations in healthcare access and practices, especially surrounding ecotherapy [1]. Ecotherapy is the practice of mindfulness in tandem with intentional immersion among natural spaces or with natural elements. Research from Asia, Europe and Canada indicate immense benefits from ecotherapy, or mindful nature immersion, as an effective treatment for burnout and stress. By adopting regular nature engagement, the U.S. could significantly improve mental health and reduce occupational stress. This literature review examines how nature immersion, especially with mindfulness, positively affects the brain and nervous system. Key components in nature are identified, such as …

Effect Of Telehealth Interventions On Hypertension Management In A Veterans Affairs Community-Based Outpatient Clinic (Cboc), Cherilyn Schumacher

Student Scholarly Projects

Practice Problem: Per U.S. Department of Veterans Affairs (2020), hypertension (HTN) is prevalent in active and retired military personnel with 13% of those in active duty and in “more than one in three Veterans…making it the most common chronic condition for Veterans” (p. 1). Per the Electronic Quality Measure (eQM) portal, a PACT clinic in a CBOC is scoring well below the national and facility benchmarks, showing a need for an intervention that will improve HTN management.

PICOT: For current veteran patients ages 18-85 assigned to a PACT (P), what is the effect of nurse-led telehealth blood pressure …

Enhancing Neonatal Resuscitation Optimizing Epinephrine Dosing And Improving Communication, Sonsare Holtzclaw

MSN Student Capstones

No abstract provided.

Improving Surgical Turnover Times, Jessica Palmer

MSN Student Capstones

No abstract provided.

Navigating Pediatric Fever: Diagnosis, Treatment And Parental Guidance, Marquita D. Mack

MSN Student Capstones

No abstract provided.

Safety Issues Due To Inadequate Utilization Of Policies And Procedures To Identify And Confiscate Dangerous Contraband Found On Patients, Onyinye Uche

MSN Student Capstones

No abstract provided.

Understanding And Enhancing Health Literacy In The Management Of Oncology Patients, Sarata Saidykhan

MSN Student Capstones

No abstract provided.

Enhancing Pain Management Practices In An Orthopedic Medical-Surgical Unit, Christiana Owusu

MSN Student Capstones

No abstract provided.

Increasing Operating Room Efficiency Through A Case Cart Facilitation And Staging Process, Susan Tomco

MSN Student Capstones

No abstract provided.

Fall Reduction In The Emergency Department, Victoria Barbee

MSN Student Capstones

No abstract provided.