Medicine and Health Sciences Commons^™

A047: Research On The Structure And Scale Of Service Quality Of Sports Park, Liping Xu, Zhihua Yin, Jian Wang

International Journal of Physical Activity and Health

Background/Purpose: Since the "14th Five-Year Plan" period, with the vigorous promotion of China and the provincial and municipal governments, the number of sports parks has shown a continuous positive trend of growth. While accelerating the construction progress, how to improve the service quality of sports parks should become the primary issue that needs to be solved to promote the sustainable and healthy development of sports parks. Therefore, based on the perspective of public demand, this study formed a scientific assessment scale by exploring the specific content structure contained in the service quality of sports parks, to promote the high-quality development …

Biological Validation Of Peak-Width Of Skeletonized Mean Diffusivity As A Vcid Biomarker: The Markvcid Consortium, Alison M Luckey, Saptaparni Ghosh, Chen-Pin Wang, Alexa Beiser, Rebecca Bernal, Zhiguang Li, Djass Mbangdadji, Elyas Fadaee, Haykel Snoussi, Angel Gabriel Velarde Dediós, Hector A Trevino, Monica Goss, Laura J Hillmer, Christopher E Bauer, Adam M Staffaroni, Lara Stables, Marilyn Albert, Jayandra J Himali, Thomas H Mosley, Lars Forsberg, Vilmundur Guðnason, Baljeet Singh, Herpreet Singh, Kristin Schwab, Joel H Kramer, Gary A Rosenberg, Karl G Helmer, Steven M Greenberg, Mohamad Habes, Danny J J Wang, Brian T Gold, Hanzhang Lu, Arvind Caprihan, Myriam Fornage, Lenore J Launer, Konstantinos Arfanakis, Sudha Seshadri, Charles Decarli, Pauline Maillard, Claudia L Satizabal

Faculty, Staff and Student Publications

BACKGROUND: Peak-width of skeletonized mean diffusivity (PSMD), a neuroimaging marker of cerebral small vessel disease (SVD), has shown excellent instrumental properties. Here, we extend our work to perform a biological validation of PSMD.

METHODS: We included 396 participants from the Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID-1) Consortium and three replication samples (Cohorts for Heart and Aging Research in Genomic Epidemiology = 6172, Rush University Medical Center = 287, University of California Davis Alzheimer's Disease Research Center = 567). PSMD was derived from diffusion tensor imaging using an automated algorithm. We related PSMD to a composite measure …

The Scoop, Vol. 11 Issue 9, December 2024, Health Sciences Library

Volume 11

Latest news and updates from the Health Sciences Library in our monthly newsletter for December 2024. Please see page 2 for a text-only version of this issue!

Comparison Of The Effect Of Heavy Pulls Vs Light Powers On A Subsequent Clean In Trained Athletes, Luke Devirgiliis

Electronic Theses and Dissertations

The sport of weightlifting has been competed since the first modern Olympiad. Competition in weightlifting consists of 3 attempts the snatch and clean and jerk declared by the athlete and their coach prior to the starting of the lift. While waiting for the athlete’s lift, waiting periods can change and warm up attempts may need to be adjusted. Often, coaches prescribe either a complete “light power” or partial “heavy pull” repetition of the competed movement during a long wait. Previous literature indicates that a heavier stimulus may cause a “post-activation potentiation”, or “post-activation performance enhancement” effect on the subsequent lift. …

Self-Rated Interprofessionalism Between Allied Health Professionals, Courtney Andrews

Electronic Theses and Dissertations

Preventable deaths due to medical errors are a significant cause of death in the United States. Decreased communication and collaboration has been cited as a potential reason for these preventable medical errors. Interprofessional practice (IPP) is a service delivery method where medical professionals from different disciplines intentionally work together in order to provide collaborated and collective care for patients. Interprofessional education (IPE) training programs are becoming more common in healthcare education, and have been cited as one way to improve IPP among healthcare providers. However, gaps exist in the literature regarding how to best structure and implement these programs so …

Enhancing Warning Signs Of Mental Health Literacy: Evaluating A Digital Base Intervention For Health Profession Students, Nashwa Ibrahim

Nursing

Background: Despite its importance, Mental health literacy (MHL) among nursing and other health profession students often remains inadequate, potentially impacting their future roles as healthcare providers. This inadequacy can lead to delayed or inappropriate care for individuals with mental health concerns, perpetuating adverse outcomes and increasing the burden on healthcare systems. Aim: To evaluate a digital-based intervention designed to enhance the warning signs of mental health literacy among health profession students. Design: A quasi-experimental, one-group pretest-posttest study design was used to conduct the current study. Methods: A non-randomized trial was conducted using digital mental health literacy intervention about the warning …

Relationship Between Nursing Care Provided For Children On Mechanical Ventilation And Their Clinical Outcomes, Marwa G. Abouheiba, Nehad S. Basiouny

Nursing

Background: Indication of mechanical ventilation are variable and diverse. It is required whenever the child is unable to maintain adequate alveolar oxygenation or ventilation. Objective: To assess the relationship between provided nursing care for children on mechanical ventilation and their clinical outcomes. Setting: The Pediatric Intensive Care Unit (PICU) of Alexandria University Children’s Hospital (AUCH)at El-Shatby. Subjects: Study subjects were included both nurses and children. The first part of the study are all nurses (30) worked at the previously mentioned setting were included this inclusion was regardless of their level of education and years of experience. The second part is …

Relationship Between Nursing Care Provided For Children Postextubated From Mechanical Ventilation And Their Reventilation., Marwa G. Abouheiba, Magda E. Youssef

Nursing

Background: Respiratory failure requires mechanical ventilation to maintain gas exchange. Extubation means endotracheal tube removal, where ventilated children maintain an efficient gas exchange without ventilatory support. If extubation fails, the children will need reventilation. Therefore, after extubation, children must receive proper nursing care to prevent reventilation. Aim: This study aims to identify the relationship between nursing care provided for children post-extubated from mechanical ventilation and their reventilation. Settings: The study was conducted at the Pediatric Intensive Care Unit of Alexandria University Children’s Hospital at El-Shatby. Subjects: A convenient sample of 50 extubated children and all nurses provided care to these …

The Fields Of Care Project: Diabetes Education For Agricultural Laborers Of Stockton, California, Matthew Medel, Juan Fernando Rosero, Valerie Visochin, Antonella Winer

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.

Promoting Mental Health For Graduate Students: The Mind Matters Initiative, Kelly Donahoe, Marissa Marchman, Anna Ramos, Silvia Reyes

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.

Empowering Community Health Promoters For Healthy Births In Sega, Kenya, Melissa Castro, Trang Ha, Dominique Tagupa, Kaliah Vang

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.

Enhancing Wellbeing In The Assisted Living Setting: Musical Memories And Pill Prep, Kinsey Hopkins, Audrey Maskiewicz, Ashley Nguyen, Kailynne Van Winkle

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.

Eat To ‘Beet’ Disease Through Improving Nutrition Literacy To Empower Citizens Of Oak Park, Ca, Lillian Messer, Erin Skowron, Isabelle Tankka, Geth Wu

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.

Care Beyond Incarceration: Grassroots Support For Community Reentry Success, Chelsea Bigelow, Rachel Bovenizer, Jessica Lebedeff

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.

Physicochemical Property Effects On Immune Modulating Polymeric Nanoparticles: Potential Applications In Spinal Cord Injury, Daniel J. Kolpek, Jaechang Kim, Hisham Mohammed, John C. Gensel, Jonghyuck Park

Markey Cancer Center Faculty Publications

Nanoparticles (NPs) offer promising potential as therapeutic agents for inflammation-related diseases, owing to their capabilities in drug delivery and immune modulation. In preclinical studies focusing on spinal cord injury (SCI), polymeric NPs have demonstrated the ability to reprogram innate immune cells. This reprogramming results in redirecting immune cells away from the injury site, downregulating pro-inflammatory signaling, and promoting a regenerative environment post-injury. However, to fully understand the mechanisms driving these effects and maximize therapeutic efficacy, it is crucial to assess NP interactions with innate immune cells. This review examines how the physicochemical properties of polymeric NPs influence their modulation of …

Independent Evolution Of Oleate Hydratase Clades In Bacillales Reflects Molecular Convergence, Robert J. Neff, Priscilla C. Lages, Shannon K. Donworth, James D. Brien, Christopher D. Radka

Markey Cancer Center Faculty Publications

Oleate hydratase (OhyA), a flavoenzyme that catalyzes the hydration of unsaturated fatty acids, has been identified in various Bacillales organisms, including those in the Listeria, Lysinibacillus, Paenibacillus, and Staphylococcus genera. In this study, we combine structural biology with molecular and phylogenetic analyses to investigate the evolutionary dynamics of the OhyA protein family within the Bacillales order. Our evolutionary analysis reveals two distinct OhyA clades (clade I and clade II) within Bacillales that, while sharing catalytic function, exhibit significant genomic and structural differences. Our findings suggest that these OhyA clades originated from independent evolutionary processes through convergent evolution rather than gene …

Msw Portfolio, Dallin C. Ball

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Understanding The Rising Use Of Fentanyl And The Impact Social Media Plays, Richard Omar Lopez

Electronic Theses, Projects, and Dissertations

This study examines how social media platforms like Reddit can be utilized to compare the discourse around fentanyl and recreational drug use. A dataset of 2549 personal experience posts were collected on fentanyl and other recreational drug use. Where the methodology included targeted queries, text processing, and natural language process (NLP) techniques such as sentiment analysis and topic modeling. Results indicate that fentanyl related discourse on Reddit was more likely to carry a cautious or neutral sentient, emphasizing its health risks or addiction. Contrasting the more positive sentiment recreational drugs carry, especially marijuana. Finding that Reddit plays a vital role …

Discrimination, Sexual Orientation, And Alcohol Amongst Latine, Brian Juarez

Electronic Theses, Projects, and Dissertations

Existing research acknowledges the influence of discrimination on alcohol use, this study emphasizes the equally significant role of sexual orientation on alcohol use. Associations between these factors and alcohol consumption demonstrate the necessity for ongoing research to analyze their intricate relationships and subsequent health outcomes. This study highlights the crucial need for an in-depth exploration of discrimination as well as marginalized identities as contributing factors in alcohol consumption.

Using a quantitative approach to assess secondary data gathered from the National Alcohol Surveys (NAS), this paper underscores the importance of a comprehensive and timely approach to research the multifaceted impact of …

Comparative Assessment Of Machine Learning And Deep Learning Models For Drug Effectiveness Using Sentiment Analysis, Blessing Ogechukwu Nwogu

Electronic Theses, Projects, and Dissertations

In recent years, the proliferation of online patient-generated drug reviews has created a valuable resource for assessing drug effectiveness and patient satisfaction, with sentiment analysis emerging as a powerful tool for extracting insights from this unstructured data.

This culminating research project conducted a comparative analysis of traditional Machine Learning (ML) and Deep Learning (DL) models for assessing drug effectiveness using sentiment analysis of participant reviews. The research aimed to evaluate the performance of Support Vector Machine (SVM), XGBoost, Random Forest, Long Short-Term Memory (LSTM), and Bidirectional Encoder Representations from Transformers (BERT) models in this context. This culminating research project addressed …

Forty-Eight-Month Clinical Outcomes Of Patients Over 60 Years Old In A Prospective, Controlled, Multicenter Study Evaluating Two-Level Cervical Disc Arthroplasty With A Peek-On-Ceramic Artificial Disc, Andrew Park, Richard Guyer, Pierce Nunley, Ashvin Patel, Jad Khalil, James Yue, Arman Khachatryan, K Brandon Strenge, Hyun Bae, Christopher Good, Rick Sasso

Conference Presentation Abstracts

Introduction: Cervical total disc replacement (cTDR) has gained acceptance as a treatment for symptomatic disc degeneration with symptoms of radiculopathy with/without myelopathy. While clinical outcomes of cTDR have consistently been reported to be similar or superior to those of cervical discectomy and fusion, there are limited reports addressing differences related to patient age. The purpose of this study was to compare the 4-year results of two-level PEEKon-ceramic cervical TDR for patients ≥60 years old to those < 60. Materials and Methods: Data were from the prospective Food and Drug Administration (FDA) Investigational Device Exemption (IDE) trial for the Simplify cervical disc. The study included 145 patients who completed 4-year follow-up, of which 124 were < 60 years old at the time of surgery and 21 were ≥60 years. All patients were treated for two-level cervical disc degeneration with radiculopathy and/or myelopathy. Clinical outcome was based on the Neck Disability Index (NDI), neck pain and arm pain intensity scores (10-point scale), and neurologic status. Radiographic measures included flexion/extension (F/E) range of motion (ROM), disc space height, heterotopic ossification, and adjacent-level degeneration based on Kellgren-Lawrence grading. Mean 48-month outcomes for patients ≥60 years old were compared to those of patients < 60. Radiographs were evaluated by an independent lab specializing in image assessment. Results: Of the outcomes reviewed, only one statistically significant difference was detected based on age group. The mean change in F/E ROM from baseline to 48 months at the inferior index level was 3.33° (< 60) and -0.19° (≥60) (p=0.01). At the superior index level, the difference was not significant (1.80° (< 60) vs. 0.12° (≥60); p=0.20). The difference in change in global ROM was also not significant (5.67° (< 60) vs. 0.77° (≥60); p=0.07). Statistically significant differences were not seen for the other outcomes assessed: mean change in NDI, mean change in neck pain, mean change in arm pain. Neurologic status was normal in 93.6% of the < 60 age group and 100.0% of the ≥60 group (p=0.24). The mean change in average disc height from baseline to 48 months was similar in both groups. The distribution of Kellgren-Lawrence grades (none, doubtful, minimal, moderate, and severe) was also similar for each age group for the level above and below the surgical levels (p=0.88 above, p=0.49 below) and the rate of radiographically relevant HO (grade 3 or 4) was comparable between age groups (superior level (p=0.49); inferior level (p=0.20)). Through latest follow-up, there were zero secondary surgical interventions in the ≥60 cohort and 9 in the < 60 cohort. Conclusion: This study found that patients ≥60 years of age who were treated with PEEK-on-ceramic TDR at two levels had comparable clinical and radiographic outcomes to patients < 60 years of age through 4-year follow-up. These results affirm that cervical TDR performs similarly in patients ≥60 versus those < 60, although the small sample size of patients ≥60 years of age is a limitation.

What Is The Difference Of A Decade Of Experience? Comparing Two Multi-Center, Prospective, Randomized Clinical Investigational Device Exemption Trials Of An Approved Tdr At Two Contiguous Levels Of The Cervical Spine, Ashvin Patel, Jad Khalil, Brian Perri, Celeste Abjornson, Feheem Sandhu, Armen Khachatryan, Pierce Nunley

Conference Presentation Abstracts

Introduction: In 2013, the first Investigational Device Exemption (IDE) clinical trial for the treatment of Symptomatic Cervical Disc Disease (SCDD) at two contiguous levels was approved for an unconstrained Total Disc Replacement (cTDR). A decade later, this same device was the control arm of a new IDE trial at 2 levels. Although different investigators, the objective of this analysis was to explore if a decade of knowledge demonstrated a significant improvement in patient outcomes compared to the original trial. Materials and Methods: Both studies were prospective, randomized, multi-center, controlled IDE clinical trials with similar inclusion/exclusion criteria and study designs. The …

Exercise Therapy Rescues Skeletal Muscle Dysfunction And Exercise Intolerance In Cardiometabolic Hfpef, Heather Quiriarte, Robert C. Noland, James E. Stampley, Gregory Davis, Zhen Li, Eunhan Cho, Youyoung Kim, Jake Doiron, Guillaume Spielmann, Sujoy Ghosh, Sanjiv J. Shah, Brian A. Irving, David J. Lefer, Timothy D. Allerton

School of Graduate Studies Faculty Publications

Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a “2-hit” model of HFpEF, we investigated the ability of exercise therapy (voluntary wheel running) to reverse skeletal muscle dysfunction and exercise intolerance. Using state-of-the-art metabolic cages and a multiomic approach, we demonstrate exercise can rescue dysfunctional skeletal muscle lipid and branched-chain amino acid oxidation and restore exercise capacity in mice with cardiometabolic HFpEF. These results underscore the importance of skeletal muscle metabolism to improve exercise intolerance in HFpEF.

Bactericidal Mechanism Of Peracetic Acid Against Salmonella Mediated By Reactive Oxygen Species, Mohammed Khalid Wheib Al-Doury

Graduate Theses and Dissertations

Peracetic acid (PAA) is extensively used as a bactericidal agent in poultry processing to reduce foodborne pathogens, including Salmonella enterica serotype Typhimurium (S. Typhimurium). Despite its widespread application, the exact mechanisms underlying its bactericidal effects, particularly the role of reactive oxygen species (ROS), remain incompletely understood. This dissertation examines the role of ROS in PAA-mediated bacterial killing and explores both genetic and metabolic factors that influence bacterial susceptibility to PAA. Findings from these studies have implications for enhancing the efficacy of PAA, thereby improving food safety practices in the industry.

The first study investigates ROS as a central component …

Service Provider Perceptions Of Systems Serving Individuals Experiencing Homelessness: A Needs Assessment And Strategic Plan In Johnson City, Tn, Opal Frye-Clark

Electronic Theses and Dissertations

This Integrated Learning Experience (ILE) investigates service providers' perceptions of Johnson City, Tennessee's homelessness services, aiming to inform a city-wide strategic plan for reduction. Employing a mixed-methods approach, the study gathered qualitative data through in-depth interviews with service providers in 2022 and quantitative data via a 2024 survey. The research focused on those directly involved in serving or significantly influencing the lives of individuals experiencing homelessness (IEH). Three key aims guided the investigation: (1) To analyze provider perspectives to identify community assets, opportunities, barriers, and unmet needs, informing a comprehensive needs assessment; (2) To refine these findings through SWOT analysis …

The Bacterial Cell Wall Components Lipopolysaccharide And Peptidoglycan Initiate Divergent Local Tissue And Systemic Inflammatory Response Profiles In The Chicken Model, Kristen A. Byrne, Gisela F. Erf

Poultry Science Faculty Publications and Presentations

The innate immune system plays an important role in the early defense against pathogens. To better understand the chicken’s innate inflammatory responses, we concurrently examined the cellular responses at the injection site and in the blood following intradermal (i.d.) injections of lipopolysaccharide (LPS) or peptidoglycan (PGN) into the pulp of growing feathers (GFs). Both LPS from Gram-negative bacteria and PGN from Gram-positive bacteria are potent stimulators of innate inflammatory responses. The time-course study conducted revealed similarly elevated levels of heterophils and macrophages in injected GF-pulps during the first 24 h for both LPS and PGN. However, PGN also stimulated rapid …

Malnutrition And Risks Of Atrial Fibrillation Recurrence After Catheter Ablation, Phuuwadith Wattanachayakul, Thitiphan Srikulmontri, Vitchapong Prasitsumrit, Thanathip Suenghataiphorn, Pojsakorn Danpanichkul, Jakrin Kewcharoen, Nipith Charoenngam, Sumeet Mainigi

Einstein Health Papers

BACKGROUND: Recent data showed an association between malnutrition and increased all-cause mortality and thromboembolic risk in patients with atrial fibrillation (AF). However, the impact of malnutrition on the clinical outcomes for patients undergoing catheter ablation for AF is still debated. Our study aimed to examine this relationship using all existing available data.

METHODS: We conducted a systematic review of MEDLINE and EMBASE databases from inception to April 2024, analyzing the association between malnutrition, assessed by the Geriatric Nutritional Risk Index (GNRI), and the risk of AF recurrence in patients who underwent catheter ablation for AF, compared to those without malnutrition. …

Sexual Orientation, Gender Identity And Virologic Failure Among People With Hiv: A Cohort Study In All Of Us Research Program, Fanghui Shi, Ruilie Cai, Buwei He, Xiaoming Li Ph.D., Xueying Yang Ph.D., Sharon Weissman, Bankole Olatosi Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Background: Sexual and gender minorities (SGMs) are at higher risk of HIV incidence compared to their heterosexual cisgender counterparts. Despite the high HIV disease burden among SGMs, there was limited data on whether they are at higher risk of virologic failure, which may lead to potential disease progression and increased transmission risk. The All of Us (AoU) Research Program, a national community-engaged program aiming to improve health and facilitate health equity in the United States by partnering with one million participants, provides a promising resource for identifying a diverse and large volunteer TGD cohort. Leveraging various data sources available through …

Efficacy And Feasibility Of Intradialytic Plantar Electrical Stimulation In Patients With Diabetes: A Randomized Double-Blind Controlled Trial, Myeounggon Lee, Abdullah Hamad, Mehrnaz Azarian, Jaewon Beom, Abderrahman Ouattas, Mohammad Dehghan Rouzi, Naima Rodriguez, Nhi Quach, Rania Ibrahim, Mincy Mathew, Talal Talal, Fadwa Al-Ali, Bijan Najafi

Center on Aging Staff Publications

Objective: This study investigates the efficacy and feasibility of electrical stimulation (E-Stim) on sensory fibers of the plantar region during hemodialysis sessions, aiming to improve mobility in patients with diabetes by providing a connection between E-Stim and enhanced mobility with minimal patient effort required.

Research design and methods: Participants aged ≥18 years with diabetes undergoing hemodialysis and able to walk at least 10 m with or without aid were recruited and divided into an intervention group receiving 1-h intradialytic E-Stim three times a week and a control group using an identical nonfunctional device for 12 weeks. Gait, physical activity, patient-reported …

The Dynamic Risk Factors Of Cardiovascular Disease Among People Living With Hiv: A Real-World Data Study, Ziang Liu, Jiajia Zhang Ph.D., Xueying Yang Ph.D., Haoyuan Gao, Shujie Chen, Sharon Weissman, Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Background: This study aims to investigate the incidence and dynamic risk factors for cardiovascular diseases (CVD) among people living with HIV (PLWH).

Methods: In this population-based statewide cohort study, we utilized integrated electronic health records data to identify adult (age ≥ 18) who were diagnosed with HIV between 2006 and 2019 and were CVD event-free at the HIV diagnosis in South Carolina. The associations of HIV-related factors and traditional risk factors with the CVD incidence were investigated during the overall study period, and by different follow-up periods (i.e., 0-5yrs, 6-10yrs 11-15yrs) using multivariable logistic regression models.

Results: Among 9,082 eligible …