Medicine and Health Sciences Commons^™

Clinical Practice Guideline: Shared Decision Making For Patients With Mental Health Disorders, Karen Rose Grant-Simmons

Walden Dissertations and Doctoral Studies

Summary This project was a clinical practice guideline (CPG) for practitioners who deliver healthcare services to patients living with mental health disorders. The practice problem addressed by this CPG was lack of mental health patient inclusion in terms of determining treatment plans of care. In back-to-back patient satisfaction surveys, patients indicated they would like to have more say in their treatment plans. The practice problem was important to increase patient input in clinical decision-making practices of practitioners. The project question was: Does evidence support development of a CPG for mental health patient-centered input regarding treatment plans of care that was …

The Anti-Inflammatory Diet Prescription For Optimal Oral Health, Liz Pearson Rd

Metro Denver Dental Society Articulator Magazine

This article explores the impact of an anti-inflammatory diet on periodontal health, highlighting research that supports its role in reducing inflammation and preventing periodontal disease. It emphasizes the benefits of diets such as the Mediterranean and Nordic diets, which can improve oral health outcomes, reduce tooth loss, and complement traditional dental treatments.

Intouch Week Of December 2, 2024, New York Medical College

InTouch

• NYMC Welcomes Wellness Ambassadors for the Academic Year
• SOM Class of 2028 Celebrates End of First Block of Classes at Friendsgiving
• Age is Just a Number: Study Shows Older Donor Livers Hold the Key to Saving More Lives
• Feature Your Artwork on the Chironian Back Cover
• Pediatrics Interest Group Volunteers Serve Families at Ronald McDonald House
• Faculty Spotlight: From Pupil to Professor: Alumni Lighting the Way at NYMC
• Student Spotlight: Danielle Diegisser Pushes the Limits in Metabolic Research

Neurofeedback: New Territories And Neurocognitive Mechanisms Of Endogenous Neuromodulation, James Sulzer, T Dorina Papageorgiou, Rainer Goebel, Talma Hendler

Faculty, Staff and Students Publications

Neurofeedback (NF) is endogenous neuromodulation of circumscribed brain circuitry. While its use of real-time brain activity in a closed-loop system is similar to brain-computer interfaces, instead of controlling an external device like the latter, the goal of NF is to change a targeted brain function. In this special issue on NF, we present current and future methods for extracting and manipulating neural function, how these methods may reveal new insights about brain function, applications, and rarely discussed ethical considerations of guiding and interpreting the brain activity of others. Together, the articles in this issue outline the possibilities of NF use …

Childhood Exposure To Interparental Physical Violence And Adult Cardiovascular Disease, Cancan Cui, Lin Liu, Haibin Li, Yitian Qi, Jiayin Song, Ning Han, Zhijia Wang, Xinyun Shang, Chen Sheng, Lois Balmer, Zhiyuan Wu

Research outputs 2022 to 2026

Importance: Childhood adverse experiences have been linked with long-term risk of cardiovascular disease (CVD), yet the transgenerational associations between interparental behaviors and CVD remain poorly understood. Objectives: To explore the association between exposure to childhood interparental physical violence and the subsequent risk of CVD and to examine whether the association is modified by adult depressive symptoms. Design, Setting, and Participants: This population-based cohort study included data from the China Health and Retirement Longitudinal Study (CHARLS), an ongoing study recruiting individuals aged 45 years or older, dated between June 1, 2011, and December 31, 2020, with a follow-up duration of 9 …

Alphafold2-Based Characterization Of Apo And Holo Protein Structures And Conformational Ensembles Using Randomized Alanine Sequence Scanning Adaptation: Capturing Shared Signature Dynamics And Ligand-Induced Conformational Changes, Nishank Raisinghani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Proteins often exist in multiple conformational states, influenced by the binding of ligands or substrates. The study of these states, particularly the apo (unbound) and holo (ligand-bound) forms, is crucial for understanding protein function, dynamics, and interactions. In the current study, we use AlphaFold2, which combines randomized alanine sequence masking with shallow multiple sequence alignment subsampling to expand the conformational diversity of the predicted structural ensembles and capture conformational changes between apo and holo protein forms. Using several well-established datasets of structurally diverse apo-holo protein pairs, the proposed approach enables robust predictions of apo and holo structures and conformational ensembles, …

Screensafefuture: A Parent-Empathetic And Pragmatic Mhealth Application For Toddlers' Brain Development Addressing Screen-Addiction Challenges, Nafisa Anjum, Md. Mehedi Hasan, Syeda Umme Salma, Liang Zhao, Maria Valero, Nazmus Sakib

Faculty Articles

The surging incidents of infants and toddlers screen addiction in the United States are becoming a pressing concern, given its compound impact on cognitive, mental, and physical growth. To address this era's critical child health and development problem, in this paper an innovative mHealth application—ScreenSafeFuture—is proposed. ScreenSafeFuture provides practical solutions that seamlessly fit into parents' busy lifestyles, acknowledging the effectiveness and convenience of smartphones as a healthcare tool. The solution includes essential features designed to enhance the experience between parents and their children under 3 years old encompassing an alternative activity advocator for a personalized parent-offspring scenario, screen time tracking …

Individualized Functional Magnetic Resonance Imaging Neuromodulation Enhances Visuospatial Perception: A Proof-Of-Concept Study, Anthony Allam, Vincent Allam, Sandy Reddy, Eric M Rohren, Sameer A Sheth, Emmanouil Froudarakis, T Dorina Papageorgiou

Duncan NRI Faculty and Staff Publications

This proof-of-concept study uses individualized functional magnetic resonance imaging neuromodulation (iNM) to explore the mechanisms that enhance BOLD signals in visuospatial perception (VP) networks that are crucial for navigation. Healthy participants (n = 8) performed a VP up- and down-direction discrimination task at full and subthreshold coherence through peripheral vision, and superimposed direction through visual imagery (VI) at central space under iNM and control conditions. iNM targets individualized anatomical and functional middle- and medial-superior temporal (MST) networks that control VP. We found that iNM engaged selective exteroceptive and interoceptive attention (SEIA) and motor planning (MP) networks. Specifically, iNM increased …

Developing Nursing Education In A Low-Income Country, Kalyn M. Renbarger, Jane Frances Anyango, Joshua Kanaabi Muliira

School of Nursing Faculty Publications

Background

Methods

Genome-Wide Association Analyses Identify Distinct Genetic Architectures For Age-Related Macular Degeneration Across Ancestries, Bryan R. Gorman, Georgios Voloudakis, Robert P. Igo Jr., Tyler Kinzy, Christopher W. Halladay, Tim B. Bigdeli, Biao Zeng, Sanan Venkatesh, Matthew P. Johnson, John Blangero

School of Medicine Publications

To effectively reduce vision loss due to age-related macular generation (AMD) on a global scale, knowledge of its genetic architecture in diverse populations is necessary. A critical element, AMD risk profiles in African and Hispanic/Latino ancestries, remains largely unknown. We combined data in the Million Veteran Program with five other cohorts to conduct the first multi-ancestry genome-wide association study of AMD and discovered 63 loci (30 novel). We observe marked cross-ancestry heterogeneity at major risk loci, especially in African-ancestry populations which demonstrate a primary signal in a major histocompatibility complex class II haplotype and reduced risk at the established CFH …

A Latent Class Assessment Of Healthcare Access Factors And Disparities In Breast Cancer Care Timeliness, Matthew Dunn, Didong Li, Marc Emerson, Caroline Thompson, Hazel Nichols, Sarah Van Alsten, Mya Roberson, Stephanie Wheeler, Lisa Carey, Terry Hyslop, Jennifer Elston Lafata, Melissa Troester

Kimmel Cancer Center Faculty Papers

BACKGROUND: Delays in breast cancer diagnosis and treatment lead to worse survival and quality of life. Racial disparities in care timeliness have been reported, but few studies have examined access at multiple points along the care continuum (diagnosis, treatment initiation, treatment duration, and genomic testing).

METHODS AND FINDINGS: The Carolina Breast Cancer Study (CBCS) Phase 3 is a population-based, case-only cohort (n = 2,998, 50% black) of patients with invasive breast cancer diagnoses (2008 to 2013). We used latent class analysis (LCA) to group participants based on patterns of factors within 3 separate domains: socioeconomic status ("SES"), "care barriers," and …

Concomitant Epidural And Longitudinal Anterior Spinal Artery Contrast Spread In A Lumbar Transforaminal Epidural Steroid Injection (Tfesi), Philip J. Koehler Iii, Paul M. Kitei, David S. Stolzenberg, Elaine H. Hatch

Rothman Institute Papers

A 78-year-old female with a remote history of L3-4 decompression and fusion presented with several months of low back and radicular leg pain. MRI revealed moderate L2-L3 spinal canal stenosis, ligamentum flavum infolding, moderate bilateral foraminal stenosis, and a grade I retrolisthesis. A right sided L2-L3 TFESI was performed using multiplanar fluoroscopic imaging with a subpedicular supraneural approach. During live iodinated contrast injection, imaging revealed concomitant epidural and central arterial contrast spread. The needle was retracted and repeat live fluoroscopic imaging demonstrated no vascular uptake. Desired epidural and nerve root contrast spread remained in place with repeat still imaging. Dexamethasone …

Predictors Of Mortality In African Americans With Alzheimer’S Disease-Related Dementias, Latrice Camille Noonan

Walden Dissertations and Doctoral Studies

Alzheimer’s disease-related dementia (ADRD) is a leading cause of death worldwide. There is a need to identify the link between modifiable risk factors and the association with ADRD mortality. This study addresses the disproportionately high burden of ADRD among African Americans, aiming to inform targeted prevention strategies and promote health equity. In this study, the longitudinal relationship between ADRD mortality and the presences of diabetes, smoking, and obesity among older African Americans residing in the United States was examined, while controlling for age, gender, education, and socioeconomic status. The biopsychosocial model served as the theoretical framework for this study. The …

Staff Education To Improve Antipsychotic Medication Adherence, Muhammad J. Matlub

Walden Dissertations and Doctoral Studies

This staff educational project addressed a gap in practice involving minimal nursing intervention to support antipsychotic medication adherence. Antipsychotic medication nonadherence results in undermanaged schizophrenia, which is associated with relapse psychotic episodes, suicidality, and violence. Therefore, the project’s purpose was to educate the providers on long-acting injectable (LAI) antipsychotic medication to facilitate the use of the medications to address antipsychotic medication nonadherence. Eight providers were involved in the educational intervention and were educated on the LAI antipsychotic treatment intervention through an interactive educational session. Knowledge surveys were administered before and after the educational intervention. The collected data were analyzed using …

Understanding Orthopaedic Infections: A Conceptual Approach, Gregory Laborde, Christopher Bloise, George Karam

School of Medicine Faculty Publications

BACKGROUND: Memorizing mounds of facts without having an effective conceptual framework to store them is often an unsuccessful learning style because memory frequently fails without understanding. To accomplish this goal, we offer a framework of ideas called "concept maps". Of the many strategies for metacognition (that is, thinking about thinking), concept mapping is proven to improve meaningful and independent learning. We used this approach to guide understanding of common orthopaedic infections. This paper is not meant to serve as an approach on how to treat, but rather as a storage system with the ability to assist in understanding orthopaedic infections. …

A Comparison Of Vestibular Function In Young Adult Musicians And Non-Musician Peers, Alexandria W. Greene, Ashley G. Flagge, Nicholas S. Stanley

Ashley Flagge Publications

Purpose: The majority of college-level musicians exceed the daily recommended noise dose level during instrumental practices and performances, although less than one-third report wearing hearing protection while playing their instruments. Although the hazardous effects of music on the auditory system have been established, even in young adult musicians still early in their musical careers, the effects of music on the vestibular system are still unclear. The purpose of the present study was to examine vestibular/balance differences between young adult musicians and non-musicians to determine the effects of music exposure on the vestibular system.

Method: Young adult participants aged 18-27 years …

Adiposity Throughout Adulthood And Risk Of Young-Onset Breast Cancer Tumor Subtypes In The Young Women's Health History Study, Lydia Marcus Post, Dorothy R. Pathak, Ann S. Hamilton, Kelly A. Hirko, Richard T. Houang, Emily H. Guseman, Dan Sanfelippo, Nicole Bohme Carnegie, L. Karl Olson, Hallgeir Rui, Ann G. Schwartz, Ellen M. Velie

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

BACKGROUND: The role of adult adiposity in young-onset breast cancer (YOBC) subtype risk is not well understood.

METHODS: In this population-based case (n = 1812)-control (n = 1,381) study of invasive YOBC (ages <50 >years), cases were identified from the Los Angeles County and Metropolitan Detroit Surveillance, Epidemiology, and End Results registries, 2010 to 2015. Area-based, frequency-matched controls were sampled from the 2010 Census. General adiposity [body mass index (BMI)] and central adiposity (waist circumference and waist-to-height ratio) across adulthood and covariates were collected from in-person interviews and measurements. ORs and 95% confidence intervals (CI) for adiposity and YOBC tumor subtypes …

Estimated Vaccine Effectiveness For Pediatric Patients With Severe Influenza, 2015-2020., Kelsey M. Sumner, Leila C. Sahni, Julie A. Boom, Natasha B. Halasa, Laura S. Stewart, Janet A. Englund, Eileen J. Klein, Mary A. Staat, Elizabeth P. Schlaudecker, Rangaraj Selvarangan, Christopher J. Harrison, Geoffrey A. Weinberg, Peter G. Szilagyi, Monica N. Singer, Parvin H. Azimi, Benjamin R. Clopper, Heidi L. Moline, Emma K. Noble, John V. Williams, Marian G. Michaels, Samantha M. Olson, New Vaccine Surveillance Network Collaborators

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Increasing the understanding of vaccine effectiveness (VE) against levels of severe influenza in children could help increase uptake of influenza vaccination and strengthen vaccine policies globally.

OBJECTIVE: To investigate VE in children by severity of influenza illness.

DESIGN, SETTING, AND PARTICIPANTS: This case-control study with a test-negative design used data from 8 participating medical centers located in geographically different US states in the New Vaccine Surveillance Network from November 6, 2015, through April 8, 2020. Participants included children 6 months through 17 years of age who were hospitalized or presented to an emergency department (ED) with acute respiratory illness. …

Connected For Joy: The Power Of Relationships In Cultivating Happiness, Amisha Singh Dds, Edd

Metro Denver Dental Society Articulator Magazine

This article explores the profound connection between human happiness and meaningful relationships. It discusses the critical role of human connection in promoting health and longevity, the impact of social isolation on well-being and the call to action to mend the social fabric. The piece also reflects on how organized dentistry fosters community, mentorship and connection, offering a vital antidote to loneliness in the dental profession.

A Different Spin On An Old Solution For Oral Health In Long-Term Care, Brooke Fukuoka Dmd

Metro Denver Dental Society Articulator Magazine

This article explores the challenges of providing oral health care in long-term care facilities, emphasizing the complexities faced by caregivers in managing oral hygiene for elderly residents. It discusses the importance of caregiver education and training, the time constraints involved, and a solution involving dental team members visiting weekly to provide assisted oral hygiene, highlighting the value of dental hygiene students in improving patient care and fostering professional development.

Beyond Dentistry: Achieving Personal And Professional Balance, Laura Brenner Dds

Metro Denver Dental Society Articulator Magazine

This article explores the challenges dental professionals face in balancing personal fulfillment with career obligations. It emphasizes the importance of self-awareness, aligning career with personal values, and rediscovering identity beyond the profession to achieve true well-being and rekindle passion for dentistry.

Biodata Drives Treatment Success, Steve Carstensen Dds

Metro Denver Dental Society Articulator Magazine

This article explores the growing role of biosignals and digital health technologies in dentistry, emphasizing how devices like wearable rings and sensors are enhancing the diagnosis and management of conditions such as obstructive sleep apnea, periodontal disease and chronic pain. By integrating biosignal data into patient care, dentists can provide more precise, personalized treatments, improving outcomes and supporting collaboration with primary care providers in managing chronic diseases.

The Power Of Prevention: Integrating Dental And Cardiovascular Care With The Baledoneen Method™, Amy Doneen Dnp

Metro Denver Dental Society Articulator Magazine

This article details the BaleDoneen Method™ which offers a collaborative, science-based approach to preventing and managing cardiovascular disease (CVD) by targeting the root causes of arterial plaque formation. This method integrates dental care by addressing high-risk periodontal pathogens, recognizing the critical connection between oral health and vascular health, and emphasizes the importance of personalized care to reduce systemic inflammation and cardiovascular risk.

Articulator Q4 2024

Metro Denver Dental Society Articulator Magazine

This issue serves as a preview for the 117^th Rocky Mountain Dental Convention (RMDC) and features articles from subject matter experts speaking at the convention in January 2025. Content includes:

• A Reflection from MDDS Co-Editor, Dr. Amisha Singh on the connection between human happiness and meaningful relationships.
• A feature from Registered Dietician, Ms. Liz Pearson, on the impacts an anti-inflammatory diet can have on oral and periodontal health.
• A feature from Dr. Brooke Fukuoka on the challenges of providing oral health care to residents in long-term care and assisted living facilities.
• An article from professional career coach, Dr. Laura …

Increasing Nursing Staff Knowledge On Medication Nonadherence Among Mental Health Patients, Princess Ndidi Amadi

Walden Dissertations and Doctoral Studies

Medication nonadherence is a challenge among patients with severe mental health disorders, increasing the patients’ risk for exacerbations of psychosis and relapse, which may result in hospital emergency room visits and hospital admissions. In patients with schizophrenia, major depressive disorders, and bipolar disorders, the mean medication nonadherence is 49%. While no single strategy works, a combination of behavioral and educational strategies has been shown to improve patient adherence to their medication regimen. The purpose of the Doctor of Nursing Practice project was to increase healthcare professionals’ knowledge of behavioral and educational strategies to improve medication adherence among patients with severe …

It’S Time To Get Hyped!, Brian Gurinsky

Metro Denver Dental Society Articulator Magazine

Dr. Brian Gurinsky, Chair of the 117th Rocky Mountain Dental Convention (RMDC), shares exciting highlights of the upcoming event. He emphasizes diverse learning formats such as lectures, hands-on workshops, Industry Ally sessions, and Professional Industry Panels featuring thought leaders. Additional features include dynamic speakers, on-demand course access, a vibrant Expo Hall, fun social events and unique wellness activities like Puppy Playtime, oral health screening and more.

Excess Mortality In Persons With Concurrent Hiv And Cancer Diagnoses: A Retrospective Cohort Study, Kamaria L Lee, Varada Sarovar, Jennifer O Lam, Wendy A Leyden, Stacey E Alexeeff, Alexandra N Lea, Rulin C Hechter, Haihong Hu, Julia L Marcus, Qing Yuan, Jennifer R Kramer, Lilie L Lin, Elizabeth Y Chiao, William J Towner, Michael A Horberg, Michael J Silverberg

Center for Medical Ethics and Health Policy Staff Publications

Background: With extended lifespans for people with human immunodeficiency virus (PWH), there is a corresponding increased burden of chronic illnesses, including cancer. Our objective was to estimate the excess mortality among PWH with cancer compared with people without HIV (PWoH), accounting for the higher background mortality in the general PWH population.

Methods: We identified 39,000 PWH and 387,767 demographically matched PWoH in three integrated healthcare systems from 2000 to 2016. We estimated excess mortality among PWH with cancer, computed as the cancer mortality rate difference-in-difference comparing PWH and PWoH. We evaluated five cancer groups: any cancer; virus-, human papillomavirus-, and …

Educating Providers On Effective Prescribing Of Benzodiazepine, Juliana Nwakamma

Walden Dissertations and Doctoral Studies

The goal of this initiative is to increase provider confidence, improve patient outcomes, and foster constructive societal change by teaching healthcare professionals how to prescribe benzodiazepines safely and effectively. Many doctors prescribe benzodiazepines to treat anxiety, sleeplessness, and seizures, but using them comes with serious hazards, such as dependence, withdrawal, and overdosing, particularly when taken with other drugs like opioids. Taking these concerns into consideration, my study intends to close gaps in prescribing practices by creating an evidence-based education program specifically designed for healthcare professionals. The course emphasizes effective prescribing techniques, methods for weaning chronic users, and benzodiazepine substitutes such …

Effectiveness Of Eucalyptus For Pain Management: An Integrative Review, Taylor Stone, Jennifer Tran

Master's Projects

This integrative review examines eucalyptus essential oil effectiveness for pain, particularly as an alternative to opioids. An extensive literature search was conducted across multiple databases, including Joanna Briggs Institue, Cochrane, CINAHL, PubMed, and Scopus, focusing on studies examining eucalyptus oil’s analgesic properties, along with its effectiveness when used alone or in conjunction with complementary therapies like massage and acupuncture. Analysis identified three key themes: (1) the effectiveness of eucalyptus oil in pain reduction across various acute and chronic pain conditions, (2) its role in potentially reducing reliance on pharmaceutical pain relief, and (3) its capacity to enhance the effectiveness of …

D101n: A Unique And Ill-Understood Familial Als-Related Sod1 Mutant, Analisa Lott

Honors Program Theses and Research Projects

Background: Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, with 90% of documented cases considered sporadic and about 10% showing a hereditary link; such cases are deemed as familial ALS (fALS). Superoxide dismutase (SOD), a copper-zinc binding enzyme that protects cells from damaging free radicals, has been linked to fALS with certain toxic gain of function mutations, such as the D101N mutant. The human SOD1 D101N mutant has been shown to be associated with rapidly progressing neurodegeneration yet is less prone to aggregation than similar mutants, but its deviation from wild-type (WT) SOD1 remains misunderstood.

Objective: Although the D101N …