Medicine and Health Sciences Commons^™

Comparison Of Rigid And Elastic Registration Methods In Software-Based Targeted Prostate Biopsy: A Multi-Center Cohort Study, Serhat Çeti̇n, Serdar Çeli̇k, Murat Koparal, Güven Aslan, Sertaç Yazici, Bahadir Şahi̇n, Si̇nan Sözen, Levent Türkeri̇

Turkish Journal of Medical Sciences

Background/Aim: This study aims to compare the success rates of rigid registration (RR) and elastic registration (ER)systems in diagnosing all cancers and clinically significant prostate cancer (csPC) in software-based targeted prostate biopsies (TPBs) by performing matching analysis.Materials and Methods: The data of 2,061 patients from six centers where software-based TPB was performed were used. All cancer and csPC detection rates of the RR and ER systems were compared following Mahalanobis distance matching within the propensity score caliper method. Logistic regression analysis was applied to identify factors predicting clinically insignificant prostate cancer (ciPC) and csPC diagnoses. Additionally, the International Society of …

Evaluation Of The Relationship Between Type Of Menopause And Cognitive Functions, Meltem Durakli Ulukök, Ufuk Atlihan, Onur Yavuz

Turkish Journal of Medical Sciences

Background/aim:Menopause is often accompanied by neurological symptoms, including cognitive difficulties, especially with memory and attention. In the present study, the purpose was to examine the relationship between the timing of menopause and the cognitive performance of menopausal patients who applied to our neurology clinic with complaints of forgetfulness.Materials and methods: The data of 538 women who applied to the neurology clinic with complaints of forgetfulness between January 2018 and January 2024and underwent neuropsychological evaluations were scanned retrospectively. A total of 96 patients who applied to neurology and menopause clinics were included in the study.Results: In the present study, attention orientation, …

Exploring Patients' Views Regarding The Support And Rehabilitation Needs Of People Living With Myocardial Ischaemia And No Obstructive Coronary Arteries: A Qualitative Interview Study, Helen Humphreys, Danielle Paddock, Sarah Brown, Aynsley Cowie, Colin Berry, Susan Dawkes, Simon Nichols

Research outputs 2022 to 2026

OBJECTIVES: This study aimed to generate new qualitative insights to understand the rehabilitation needs of people living with a confirmed or presumed diagnosis of ischaemia with no obstructive coronary arteries (INOCA), explore which aspects of current cardiovascular prevention and rehabilitation programmes could meet the needs of people with INOCA and where adjustments (if any) may be appropriate. DESIGN: Semistructured qualitative interview study. PARTICIPANTS: Interviews were undertaken (n=17; 88% female, age range 31-69 years) with people with a confirmed or presumed diagnosis of INOCA. RESULTS: Findings highlighted concerns around a lack of evidence-based guidance for cardiovascular prevention and rehabilitation programmes for …

Imlunestrant, An Oral Selective Estrogen Receptor Degrader, As Monotherapy And In Combination With Targeted Therapy In Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Phase Ia/Ib Ember Study, Komal L Jhaveri, Cynthia X Ma, Et Al.

2020-Current year OA Pubs

PURPOSE: Imlunestrant is a next-generation oral selective estrogen receptor (ER) degrader designed to deliver continuous ER target inhibition, including in

METHODS: An i3+3 dose-escalation design was used, followed by dose expansions of imlunestrant as monotherapy or in combination with abemaciclib with or without aromatase inhibitor (AI), everolimus, or alpelisib. Imlunestrant was administered orally once daily and with the combination partner per label.

RESULTS: Overall, 262 patients with ER+/HER2- ABC were treated (phase Ia, n = 74; phase Ib, n = 188). Among patients who received imlunestrant monotherapy (n = 114), no dose-limiting toxicities or discontinuations occurred. At the RP2D (400 …

A Survey Of Root Canal Treatment In Kurdish Community: A Pilot Study, Adil Othman Abdullah

Polytechnic Journal

Objective To analyze and describe the techniques and procedures employed in root canal treatment in the Kurdistan Region.

Method This study was conducted in 2023 and involved a simple random sample of 210 dentists/endodontists practitioners. The survey was spread throughout both private and governmental sectors in three distinct locations within the Kurdistan Region. The study aimed to enhance dentists' awareness and knowledge of the latest devices and advanced techniques used in the field of endodontics. The data were evaluated using basic summary statistics.

Results The eighty seven percentage of the practitioners responded. The majority of participants reported using step-back instrumentation …

Physician Assistant Students As Agents Of Change Through Service-Learning Opportunities, Kelli Frost ,Ms, Pa-C, Nour Lyon ,Ms, Pa-C, Arthur Ko ,Phd, Claire Barry ,Pa-S, Michael Martin ,Mals

Jesuit Higher Education: A Journal

Community outreach and the integration of cultural competency are essential to the education and development of healthcare professionals. This article describes incorporating service-learning into a course at a Jesuit and Mercy institution as a method of building cultural competency into a Physician Assistant (PA) curriculum. The project examined how service-learning impacted students’ understanding of community needs and allowed students to reflect on their values. In addition, it aimed to inspire students to build connections with vulnerable populations and have concern for the poor and marginalized. Students participated in service opportunities with a community partner to identify and meet the needs …

Gender Segregation In Caring Labor: The Impact Of Social Norms On Career Choices, Evelyn Xinhui Cheng

CBER Conference

Women engage in work stereotypically seen as "women's work," or work based on the perceived "natural" female tendency towards caring and relational thinking (Tung 2000). In pre-reform China, Shu (2005) found that women were more concentrated in the lowerpaying collective sector compared to men in the state-owned sector, contributing to the gender wage gap. China's horizontal occupational segregation by gender has significant implications for gender pay gaps, workforce attachment, and the perceived value of caring labor in society. Feminist scholars argue that gendered norms around caring originate that conflate womanhood with nurturing (England 2005; Litt & Zimmerman 2003). The main …

Impact Of Pathogenic E. Coli In Drinking Water On The Well-Being Of Children, Aysha Khatoon

CBER Conference

Despite global advancements, unsafe drinking water is a major cause of illness, ranked as the eighth highest worldwide (Forouzanfar et al., 2015). Studies indicate that even improved water sources, can harbour faecal contamination (Shaheed et al., 2014; Bain et al., 2014b). Globally, 1.8 billion people rely on drinking water contaminated with faecal matter (Bain et al., 2014a), with pathogenic E. coli being a primary concern. In Pakistan, the situation is dire. About 25 million people, particularly children, suffer due to open defecation, leading to 53,000 child deaths annually from diarrhoea (UNICEF, 2021). Pathogenic E. coli is a significant contributor to …

Enhancing Disaster Response Competencies In Nursing Education Through Simulation-Based Training: An Integrated Literature Review, Paul Dreater

DNP Qualifying Manuscripts

Objectives: This integrated literature review aimed to identify and prioritize disaster management education content to equip undergraduate and graduate nursing students with the necessary knowledge and skills for competent disaster response.

Data sources and review method: A literature search was conducted across multiple databases, including Cochrane, CINAHL, PsycINFO, PubMed, Google Scholar, Fusion, and Scopus, using keywords such as disaster nursing, disaster preparedness, simulation, education, and mass casualty incidents. Filters restricted results to English-language studies from the past ten years within nursing education. Selected articles were reviewed and summarized to address the research question: What are the essential disaster …

Improving Diabetes Self-Management Skills Among Adults With Type 2 Diabetes Through Weekly Education, Carthia Joachim

Dissertations

Type 2 Diabetes Mellitus is one of the major health issues worldwide, which has led to many health complications, such as cardiovascular disease, nerve damage that leads to limb amputation, kidney damage, and even death (Sameer et al., 2020). Lack of self-care management is one of the reasons diabetes is becoming such an issue in society. Studies have shown that T2DM outcomes can be improved by implementing diabetes self-management education (DSME) (Hailu et al., 2019). The study evaluated the effectiveness of DSME intervention in adult patients with T2DM over 12 weeks in Orlando, Florida. Using a structured education program, the …

The Physical And Psychological Impacts Of Exercise On Hypermobile Ehlers-Danlos Syndrome: A Case Study, Savannah Posey

Honors Projects

Hypermobile Ehlers-Danlos Syndrome (hEDS) is a subtype of a series of connective tissue disorders identified by joint hypermobility and multisystemic symptoms. It is caused by a lack of collagen production affecting the body’s ability to support important structures such as muscle, bone skin, and other connective tissues. To study the physical and psychological impacts of exercise on hypermobile Ehlers-Danlos Syndrome, a seven-week, phased exercise intervention program was implemented for a nineteen-year-old male with the disease. The program consisted of three phases focused on the strengthening of the surrounding musculature of the glenohumeral joint, along with improving muscular endurance and proprioception. …

Ada News - 12/09/2024, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Intouch Week Of December 9, 2024, New York Medical College

InTouch

• NYMC Donors Make an Impact This Giving Tuesday
• Medical Students Inspire Youth During Black Men in White Coats Summit
• 29th Annual MSRF Set for December 13
• GSBMS Celebrates Friendsgiving
• NYMC Alumni/Student Fall Mixer Builds Connections and Professional Insights
• Human Milk for Extreme Preemies: A Kosher Option
• Artificial Intelligence Can Revolutionize Acute Stroke Care
• Design the Next NYMC T-Shirt
• NYMC and TU Hosts “Ninety Minutes: The Medical Magazine of the Web”
• In The Community: GSA 5K Raises Awareness for Food Insecurity, Fundraising Continues
• Faculty Spotlight: From Pupil to Professor: Alumni Lighting the Way at NYMC

Examining The Effects Of Language Barriers For Non-Native English Speakers In The Healthcare System In Northwest Ohio, Sarah Witt

Honors Projects

Hundreds of thousands of people in the state of Ohio speak a language other than English, and communication in a predominantly English-speaking state can prove not only cumbersome, but dangerous as well. Patients who have difficulties communicating with their healthcare providers experience higher rates of medical error, adverse medical reactions because of improper drug use, longer hospital stays, and more hospital readmissions than the general population. Additionally, they experience high rates of anxiety and frustration when receiving medical care, which causes resentment and mistrust of the healthcare system. This study investigated language barriers in healthcare systems across Northwest Ohio by …

H. H. Holmes: Savage Monster Or Cruel Conman?, Max Ewoldt

Bakerman Student Research Awards

No abstract provided.

Enhancing Disaster Preparedness In Nursing Education: A Quality Improvement Approach Using Simulation And Training, Paul Dreater

Doctor of Nursing Practice (DNP) Projects

Background: Natural or artificial disasters threaten safety and continuity in educational settings. The University of San Francisco School of Nursing and Health Professions (USF SONHP) identified a critical gap in its disaster preparedness, underscored by the absence of a comprehensive disaster plan. This shortfall highlights the need for an educational strategy encompassing disaster readiness and response, particularly given the potential for such events to cause substantial harm and disruption.

Local Problem: A gap analysis conducted at the USF SONHP revealed the lack of a structured disaster plan, underlining the urgent need for an initiative to develop and implement a comprehensive …

High Intracranial Pressure Following Endoscopic Third Ventriculostomy: Illustrative Case, Zachary Sokol, Rohan V. Gupta, Robert Ziechmann, Scott R. Shepard

Jefferson Hospital Staff Papers and Presentations

BACKGROUND: Endoscopic third ventriculostomy (ETV) is an effective procedure for the treatment of triventriculomegaly associated with aqueductal stenosis. However, some patients can develop severe and symptomatic intracranial pressure (ICP) elevations in the immediate postoperative period that can be monitored and treated with external ventricular drain (EVD) placement and controlled cerebrospinal fluid (CSF) diversion until the ICP normalizes and symptoms resolve.

OBSERVATIONS: The authors describe the case of a 39-year-old male who underwent ETV and intraoperative EVD placement for obstructive hydrocephalus associated with aqueductal stenosis. The patient was noted to have sustained ICP elevations in the immediate perioperative period but ultimately …

Access To Virtual Care In Behavioral Health: A Social Determinant Of Health, Patrick J. Hearle, Emily A. Smith, Richard J. Caplan, Ram A. Sharma

SKMC Student Presentations and Publications

Abstract Objective: In the wake of COVID-19, the use of virtual modalities to provide healthcare has increased significantly. While virtual care services, particularly for behavioral health encounters, have become commonplace in many healthcare systems, there is limited data describing to what extent access to virtual care is affected by social determinants of health. The present study aims to characterize the utilization of virtual (video, phone) and non-virtual (in—person office visits) behavioral health care encounters among differing socioeconomic and demographic populations in two campuses served by a tertiary care center in Delaware to identify trends and potential barriers to these services. …

12.09.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Employee Profiles

In Person Account Reconciliation and Tableau Training

NSF Proposals with Consultant or Professional Services

Delirium Screening Practices For Older Adults In Emergency Departments Across United States: A Scoping Review, Azmat Sidhu, Joy K. Luzingu, Sheneil Agyemang, Arushi M. Chalke, Grace M. Leito, Joseph A. Molina, Zhao Chen, Deborah Jean Mcclelland, Nimit Agarwal, Leah Steckler, Angela Wu

Journal of Geriatric Emergency Medicine

Delirium is commonly missed among older patients in the Emergency Department (ED). Identifying and managing patients with delirium in ED is critical to help improve health outcomes and prevent falls and readmission. There are several validated delirium screening tools but their utilization for assessing delirium in emergency department settings are still under investigation. The overall purpose of this review was to summarize information on current screening practices for delirium among older adults (65 or older) in EDs across United States and to identify current gaps in knowledge and evidence to help inform future research and practice. A comprehensive literature search …

A Multifactorial Fall Prevention Program, Virale Patel, Zeida Gutierrez

Fall 2024 OTD Capstone Symposium

Falls among older adults are a pressing public health concern, leading to significant physical, psychological, and economic consequences. This capstone project aimed to design and implement a multifactorial fall prevention program to address unmet occupational needs and enhance safety and occupational participation among long-term care residents at a skilled nursing facility. The six-week program included targeted weekly sessions focusing on behavior modification, footwear safety, adaptive equipment training, strength and balance exercises, toileting strategies, and environmental modifications. Pre- and post-program assessments utilized the Fall Efficacy Scale International (FES-I) and participant surveys to evaluate changes in confidence, fear of falling, and satisfaction …

Training Staff Members And Caregivers On Utilizing Allen Cognitive Levels To Aid Individuals Living With Alzheimer's And Dementia To Maintain Activities Of Daily Living, Kristy Boyd, Cassandra Nelson, Jennifer Summers

Fall 2024 OTD Capstone Symposium

This capstone project is about training staff members and caregivers on utilizing the Allen's cognitive levels to aid individuals living with Alzheimer's and dementia to maintain their activities of daily living by creating a program that consists of modules, physical demonstration, and a deliverable for staff members and caregivers as well as therapeutic activities and sensory regulation activities for the participants.

Itaconate Transporter Slc13a3 Impairs Tumor Immunity Via Endowing Ferroptosis Resistance, Heng Lin, Kole Tison, Yuheng Du, Paul Kirchhoff, Chan Kim, Weichao Wang, Hannah Yang, Michael Pitter, Jiali Yu, Peng Liao, Jiajia Zhou, Linda Vatan, Sara Grove, Shuang Wei, Thomas Vigil, Yatrik M Shah, Richard Mortensen, Ilona Kryczek, Lana Garmire, Jwala P Sivaccumar, Ashwin Kumar Ramesh, Ningyan Zhang, Zhiqiang An, Shaomeng Wang, Weiping Zou

The Brown Foundation: Institute of Molecular Medicine

Immune checkpoint blockade (ICB) triggers tumor ferroptosis. However, most patients are unresponsive to ICB. Tumors might evade ferroptosis in the tumor microenvironment (TME). Here, we discover SLC13A3 is an itaconate transporter in tumor cells and endows tumor ferroptosis resistance, diminishing tumor immunity and ICB efficacy. Mechanistically, tumor cells uptake itaconate via SLC13A3 from tumor-associated macrophages (TAMs), thereby activating the NRF2-SLC7A11 pathway and escaping from immune-mediated ferroptosis. Structural modeling and molecular docking analysis identify a functional inhibitor for SLC13A3 (SLC13A3i). Deletion of ACOD1 (an essential enzyme for itaconate synthesis) in macrophages, genetic ablation of SLC13A3 in tumors, or treatment with SLC13A3i …

Bowen’S Disease Mimicking Lichen Simplex Chronicus In A 56-Year-Old Filipino Man: A Case Report, Cynthia Angela Karim, Elisabeth Ryan, Reynaldo Ugalde

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Bowen's disease (BD) is a chronic skin condition presenting clinically as erythematous plaques with scales on sun-exposed areas. BD is generally regarded as a squamous cell carcinoma (SCC) in situ. In contrast, lichen simplex chronicus (LSC), also known as neurodermatitis, is a chronic skin disorder characterized by extreme pruritus. In LSC, lichenified plaques form primarily on accessible body parts due to repeated scratching or rubbing.

Case Illustration: A 56-year-old male presented with a solitary chronic plaque with a central ulcer and erosions on his left upper thigh. Dermoscopy findings were glomerular vessels and a scaly surface, which are …

Association Of Unmet Social Needs With Disease-Related Outcomes In Pediatric Patients With Sickle Cell Disease, Molly Sonenklar, Sarah Marks, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler

School of Medicine Faculty Publications

Background: Social determinants of health (SDoH) are socioeconomic factors that influence health and well-being, though when unmet can greatly contribute to health disparities. Individuals with sickle cell disease (SCD) are at increased risk of mortality, disability, and healthcare utilization. However, there are limited data linking specific social needs with disease outcomes in this population. Therefore, we sought to identify the unmet needs in one institution and their association with healthcare utilization. Methods: Children with SCD and their guardians answered demographic and SDoH questionnaires during routine Sickle Cell Clinic appointments. We defined an unmet social need as any positive answer to …

Appropriateness Of Ambulatory Antibiotic Prescribing In South Carolina, 2012–2017, Pamela Bailey, Majdi N. Al-Hasan, Julie Royer, Max Habicht, Julie Ann Justo, P. Brandon Bookstaver Pharm.D., Sharon Weissman, Hana R. Winders

Faculty Publications

This population-based cohort study examines the appropriateness of antibiotic prescribing in South Carolina via aggregated pharmacy claims data matched with diagnosis codes from medical claims. Inappropriate antibiotic prescribing decreased from 30.2% in 2012 to 22.6% in 2017 (P < 0.001) and was more common in adults >40 years old.

Adipocyte-Derived Small Extracellular Vesicles Exacerbate Diabetic Ischemic Heart Injury By Promoting Oxidative Stress And Mitochondrial-Mediated Cardiomyocyte Apoptosis, Lu Gan, Jianli Zhao, Peng Yao, Theodore A. Christopher, Bernard Lopez, Wayne B. Lau, Walter Koch, Erhe Gao, Xin-Liang Ma, Yajing Wang

Department of Emergency Medicine Faculty Papers

BACKGROUND: Diabetes increases ischemic heart injury via incompletely understood mechanisms. We recently reported that diabetic adipocytes-derived small extracellular vesicles (sEV) exacerbate myocardial reperfusion (MI/R) injury by promoting cardiomyocyte apoptosis. Combining in vitro mechanistic investigation and in vivo proof-concept demonstration, we determined the underlying molecular mechanism responsible for diabetic sEV-induced cardiomyocyte apoptosis after MI/R.

METHODS AND RESULTS: Adult mice were fed a high-fat diet (HFD) for 12 weeks. sEV were isolated from plasma or epididymal adipose tissue. HFD significantly increased the number and size of plasma- and adipocyte-derived sEV. Intramyocardial injection of an equal number of diabetic plasma sEV in nondiabetic …

¿Qué Dijo El Médico?: Creating A Procedural Preparation Booklet For Spanish-Speaking Patients And Families In The Pediatric Hospital Setting, Caitlyn Bockbrader

Honors Projects

The purpose of my Honors Project is to demonstrate the need for and creation of a resource that supports Spanish-speaking children’s ability to cope through commonly stressful medical procedures. In developing this project, I conducted a literature review on the efficacy of preparation booklets in lessening pre-procedural anxiety, cultural considerations for the Hispanic community, and current barriers to equitable language access in healthcare settings. My final product was designed to answer the following question: How can the psychosocial outcomes of Spanish-speaking children in U.S. hospitals be improved through the use of Child Life procedural preparation materials? In answering this question, …

Physical Fitness And Nutrition In Collegiate Musical Theater Programs, Alexis Ochi, Amy Morgan Ph.D, Mary-Jon Ludy Ph.D.

Honors Projects

BACKGROUND: Athleticism and physical fitness are often not the first characteristics one identifies when visualizing someone in musical theater. Watching just one performance can make it clear that dancing, acting, running, all while singing and keeping near perfect pitch requires a theater actor to be extremely fit. As well as fitness, nutrition considerations and injury prevention should also be considered due to the high physiological demand placed on these performers. Minimal research has been conducted regarding the fitness and nutritional habits of musical theater performers. PURPOSE: This study investigated the prevalence of discussions about fitness and nutrition in collegiate musical …

Wearable Surface Electromyography System To Predict Freeze Of Gait In Parkinson's Disease Patients., Anna Moore, Jinxing Li, Christopher H Contag, Luke J Currano, Connor O Pyles, David A Hinkle, Vivek Shinde Patil

Neuroscience Articles

Freezing of gait (FOG) is a disabling yet poorly understood paroxysmal gait disorder affecting the vast majority of patients with Parkinson's disease (PD) as they reach advanced stages of the disorder. Falling is one of the most disabling consequences of a FOG episode; it often results in injury and a future fear of falling, leading to diminished social engagement, a reduction in general fitness, loss of independence, and degradation of overall quality of life. Currently, there is no robust or reliable treatment against FOG in PD. In the absence of reliable and effective treatment for Parkinson's disease, alleviating the consequences …