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Articles 38161 - 38190 of 325748

Full-Text Articles in Medicine and Health Sciences

Direct-Acting Antivirals For Chronic Hepatitis C Virus Infection In Children With Malignancy: A Review Of Current Evidence And Clinical Insights, Ashrakat Galal Aboelfotoh, Ahmad Darwish Mohamad, Ahmed Megahed Hassan Jan 2025

Direct-Acting Antivirals For Chronic Hepatitis C Virus Infection In Children With Malignancy: A Review Of Current Evidence And Clinical Insights, Ashrakat Galal Aboelfotoh, Ahmad Darwish Mohamad, Ahmed Megahed Hassan

Mansoura Medical Journal

In children, hepatitis C virus (HCV) remains a serious health concern, especially those receiving cancer treatment, where repeated blood transfusions and immunosuppression significantly increase the risk of infection. The use of direct-acting antivirals (DAAs) represents a turning point in HCV management, delivering high cure rates with fewer side effects than previous therapies. In this review, we explore the latest insights into HCV epidemiology, transmission, and pathophysiology in pediatric patients, with particular attention to those facing malignancy. We will discuss the mechanisms of action, approved treatment regimens, and safety profiles of DAAs, focusing on combinations like sofosbuvir/ledipasvir in the oncology setting. …

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Pulsed Radiofrequency Of Suprascapular Nerve Versus Radiofrequency Ablation Of Articular Branches Of The Shoulder For Intractable Shoulder Pain: A Randomized Controlled Study, Elsayed M. Elemam, Mahmoud M. Alseoudy, Ahmed R. Abourezk Jan 2025

Pulsed Radiofrequency Of Suprascapular Nerve Versus Radiofrequency Ablation Of Articular Branches Of The Shoulder For Intractable Shoulder Pain: A Randomized Controlled Study, Elsayed M. Elemam, Mahmoud M. Alseoudy, Ahmed R. Abourezk

Mansoura Medical Journal

BackgroundChronic shoulder pain is frequent in the community and can cause considerable functional impairment. The suprascapular nerve (SSN) is responsible for approximately 70% of the sensory innervation to the shoulder joint.Objectives: This randomized controlled trial aimed to compare the efficacy of pulsed radiofrequency treatment of the SSN with thermal radiofrequency ablation of the articular branches of the shoulder among patients with persistent shoulder pain.Methods 82 patients were randomly allocated into two equal groups; group PRF included patients who underwent pulsed radiofrequency of the suprascapular nerve, and group TRF included patients who underwent thermal radiofrequency ablation of articular terminal branches of …

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Short Term Outcome In Pediatric Age Group Presented With Severe Head Injury, Ahmed Nazem Elafifi, Hatem Ibrahim Badr, Amr Farid Khalil, Magdy Basheer Jan 2025

Short Term Outcome In Pediatric Age Group Presented With Severe Head Injury, Ahmed Nazem Elafifi, Hatem Ibrahim Badr, Amr Farid Khalil, Magdy Basheer

Mansoura Medical Journal

Background Pediatric head injury has been recognized as a significant public health issue, frequently resulting in disability & mortality among youth, & makes significant requirements on health services Aim To evaluate the short-term results in pediatric age group presented with severe head injury at Mansoura university emergency hospital, focusing on primary outcomes such as mortality and return to normal consciousness and secondary outcomes, including disability and cognitive dysfunction, to understand survival and post-injury quality of life. Patients and methods This prospective observational research has been conducted on 86 cases presented with head trauma and was conducted for 1 year starting …

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Relationship Between Serum Micro-Rna 192 And 29c And Kidney Disease In Subjects With Type 2 Diabetes Mellitus, Amr Y. El Feky, Talaat A. Abdelaaty, Azza A. Ismail, Rania M. Elsharkawy, Mohamed F. Amara, Shimaa M. Elrahmany Jan 2025

Relationship Between Serum Micro-Rna 192 And 29c And Kidney Disease In Subjects With Type 2 Diabetes Mellitus, Amr Y. El Feky, Talaat A. Abdelaaty, Azza A. Ismail, Rania M. Elsharkawy, Mohamed F. Amara, Shimaa M. Elrahmany

Mansoura Medical Journal

Background Diabetic kidney disease (DKD) is a frequent and serious complication of type 2 diabetes mellitus (T2DM). This study aimed to assess the relationship between micro- RNA (miRNA)-192 and miRNA-29c expression and DKD in patients with T2DM. Patients and methods A case-control study was conducted with 160 participants: 40 T2DM patients with DKD, 40 T2DM patients without DKD, and 80 healthy controls. Plasma levels of miRNA-192 and miRNA-29c were quantified using quantitative reverse transcription PCR. Diagnostic accuracy was assessed via ROC curve analysis. Multivariate logistic regression identified predictors of DKD. Results Micro RNA-192 expression was significantly elevated while miRNA-29c expression …

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Predictive Value Of Procalcitonin In Patients With Hepatitis C Virus Related Liver Cirrhosis And Sepsis, Omar Abdallah, Elshimaa Saad Eleraky, Doaa A. A. Abdeldayem, Mohamed Hossam El-Dein Zaghloul, Mohamed El-Saadany Jan 2025

Predictive Value Of Procalcitonin In Patients With Hepatitis C Virus Related Liver Cirrhosis And Sepsis, Omar Abdallah, Elshimaa Saad Eleraky, Doaa A. A. Abdeldayem, Mohamed Hossam El-Dein Zaghloul, Mohamed El-Saadany

Mansoura Medical Journal

Infection is a major source of morbidity and mortality in patients with liver cirrhosis. In about 30% of patients, bacterial infection is present on admission or develop during hospitalisation. Early detection of bacterial infection in patients with decompensated cirrhosis remain a major challenge, where time plays a crucial role. This study was conducted aiming to find the prognostic value of PCT in the patients with liver cirrhosis presenting with sepsis. During the period from June 2021 to December 2021, 75 subjects were enrolled. 50 patients with Hepatitis-C Virus (HCV) cirrhosis with sepsis. 25 patients had compensated cirrhosis while the other …

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The Effect Of Parathyroidectomy Compared To Pharmacological Treatment On Biochemical Markers And Quality Of Life Among Maintenance Hemodialysis Patients With Secondary Hyperparathyroidism, Ahmed Bahie, Dina Abd El Halim Shahin, Magdy Elsaid Abd Elmagid Samour, Elshahat Ali Ahmed Mohamed Yousef Jan 2025

The Effect Of Parathyroidectomy Compared To Pharmacological Treatment On Biochemical Markers And Quality Of Life Among Maintenance Hemodialysis Patients With Secondary Hyperparathyroidism, Ahmed Bahie, Dina Abd El Halim Shahin, Magdy Elsaid Abd Elmagid Samour, Elshahat Ali Ahmed Mohamed Yousef

Mansoura Medical Journal

Background One-third of maintenance hemodialysis (HD) patients develop severe secondary hyperparathyroidism (SHPT). Parathyroidectomy (PTx) is recommended for resistant SHPT, but calcimimetics have reduced the need for surgery. Aim of the work: to compare biochemical and QoL parameters in HD patients with SHPT who underwent PTx to those treated medically. Subject and methods in a cross-sectional study, 200 maintenance HD patients in two equal groups: A (patients on medical treatment) and B (PTx patients). In Group A, 32 patients received Cinacalcet. A thorough history, anthropometrics, clinical examination, Electrocardiography and full laboratory tests including serum calcium (sCa), phosphorus (sPhos), intact parathormone (iPTH) …

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Application Of Milan System In Cytological Diagnosis Of Salivary Gland Lesions And Its Association With Histopathology, Asmaa Sabry Gad, Heba Salah Eldin Hany, Wagdi Fawzi Elkashef, Mie Ali Mohamed Jan 2025

Application Of Milan System In Cytological Diagnosis Of Salivary Gland Lesions And Its Association With Histopathology, Asmaa Sabry Gad, Heba Salah Eldin Hany, Wagdi Fawzi Elkashef, Mie Ali Mohamed

Mansoura Medical Journal

Background: Salivary gland harbors a wide variety of non-neoplastic & neoplastic conditions that show heterogenicity in the same tumor tissue. The Milan System for Reporting Salivary Gland Cytology was designated to offer a standardized universally accepted reporting format for Salivary Gland FNAC. Aim: To apply Milan system for salivary gland and assess its accuracy by comparing the cytology and histopathology. Methods: In this retrospective study, the Milan system was applied on 81 FNAC cases referred to pathology lab at Oncology Centre Mansoura University during 5 years & compared results with postoperative biopsy. For cytological samples, Hematoxylin & Eosin-stained smears, cell …

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Antifibrotic Effects Of Fucoidan Compound On Experimental Hepatic Schistosomiasis, Eman Alaa Eldin Nazir Mohamed, Nairmen Nabih Ahmed, Suzan Hassan Elgendy, Zeinab Mohamed Ahmed Gawesh, Soha Ibrahim Awad Jan 2025

Antifibrotic Effects Of Fucoidan Compound On Experimental Hepatic Schistosomiasis, Eman Alaa Eldin Nazir Mohamed, Nairmen Nabih Ahmed, Suzan Hassan Elgendy, Zeinab Mohamed Ahmed Gawesh, Soha Ibrahim Awad

Mansoura Medical Journal

Background Schistosomiasis is a prevalent fibrotic disease characterized by inflammation and fibrous tissue deposition around Schistosoma eggs trapped in the hepatic tissue. This work aimed to evaluate the anti-fibrotic and anti-parasitic effects of fucoidan during the chronic phase of experimental schistosomiasis-mansoni in mice. Methods Sixty female Swiss albino mice were allocated into six groups; non-infected unmanaged mice group, infected unmanaged mice group, non-infected fucoidanmanaged mice group, infected fucoidan-managed mice group, infected PZQ-managed mice group, and infected combined fucoidan and PZQ managed mice. Every liver tissue was examined parasitologically, histopathologically, and by anti-transforming growth factor-beta (TGF-β) immunohistochemically. Serum was used to …

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St-Segment Resolution As A Predictor Of Short-Term Clinical Outcomes In Patients With Acute Anterior St-Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention, Mohamed Ali Nada, Eid Mohamed Daoud, Ahmed Mohamed Reda Jan 2025

St-Segment Resolution As A Predictor Of Short-Term Clinical Outcomes In Patients With Acute Anterior St-Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention, Mohamed Ali Nada, Eid Mohamed Daoud, Ahmed Mohamed Reda

Mansoura Medical Journal

Background: Acute anterior ST-elevation myocardial infarction (STEMI) carries a high risk of adverse outcomes despite advances in reperfusion therapy. ST-segment resolution (STR) on electrocardiography has been proposed as a simple marker of myocardial reperfusion and predictor of clinical, but its prognostic role in routine practice remains debated. Aim of the Work: To assess the efficacy of ST-segment resolution as a predictor of short-term clinical outcomes in patients with acute anterior STEMI undergoing primary percutaneous coronary intervention (PCI). Patients and Methods: A prospective observational study was conducted at Mansoura University Cardiology Department between January and June 2024. 98 patients with anterior …

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Interleukin-38 Serum Level In Nonsegmental Vitiligo Patients And Its Correlation With Disease Activity And Disease Severity, Aya Adel, Mohammed El- Kamel, Manar Ali Hassan Jan 2025

Interleukin-38 Serum Level In Nonsegmental Vitiligo Patients And Its Correlation With Disease Activity And Disease Severity, Aya Adel, Mohammed El- Kamel, Manar Ali Hassan

Mansoura Medical Journal

Background Vitiligo is a multifactorial disease in which autoimmunity plays a central role. Interleukin (IL)-38, an innate immune cytokine secreted by keratinocytes and other cells, is believed to have a role in vitiligo progression. Aim To assess the serum levels of IL-38 in cases with non-segmental vitiligo and to examine its correlation to disease severity and disease activity. Methods This case control study included 60 patients with vitiligo and 20 healthy subjects as a control group. According to the disease severity, the cases were allocated into three groups: mild, moderate and severe. Each group included 20 patients. The affected body …

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The Use Of Coronary Sinus Diameter Measurements To Distinguish Atrioventricular Nodal Reentrant Tachycardia From Atrioventricular Reentrant Tachycardia, Mohamed Ibrahim Ataalla Khalil, Sherif Abd El Salam Sakr, Hany Mahmoud Abd Elshakour, Hoda Mohamed Sobh Jan 2025

The Use Of Coronary Sinus Diameter Measurements To Distinguish Atrioventricular Nodal Reentrant Tachycardia From Atrioventricular Reentrant Tachycardia, Mohamed Ibrahim Ataalla Khalil, Sherif Abd El Salam Sakr, Hany Mahmoud Abd Elshakour, Hoda Mohamed Sobh

Mansoura Medical Journal

Background: Supraventricular tachycardia (SVT) is a common clinical arrhythmia, with atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular reentrant tachycardia (AVRT) being the most frequent subtypes. Distinguishing between these arrhythmias is crucial for determining the appropriate treatment strategy. Aim: To evaluate the clinical utility of echocardiographic measurement of coronary sinus (CS) diameter in distinguishing AVNRT from AVRT. Methods: This prospective descriptive study included 54 patients with narrow complex tachycardia who underwent echocardiography then electrophysiology study (EPS). CS diameter was measured at the ostium and 1 cm distal using 2D echocardiography then CS ostium area by 4D echocardiography was measured. Results: Patients …

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The Impact Of Effective Diabetes Management On Reducing Burden In Elderly Patients: A Case-Control Study, Eslam Abdelhamid Mohamed, Mohamed A. Helaly, Ahmed Albehairy Jan 2025

The Impact Of Effective Diabetes Management On Reducing Burden In Elderly Patients: A Case-Control Study, Eslam Abdelhamid Mohamed, Mohamed A. Helaly, Ahmed Albehairy

Mansoura Medical Journal

Background and aim: Elderly individuals with diabetes mellitus (DM) are more prone to experiencing common geriatric syndromes, which include impaired cognition, dementia, frailty, falls, fractures, urinary incontinence, and disability. These can significantly impair their quality of life (QoL) and could conflict with anti-diabetic medication. Therefore, we aim to evaluate the impact of controlling diabetes on the overall burden of diabetes in the elderly. Materials and Methods: 100 elderly patients over sixty-five with type 2 diabetes mellitus (T2DM) were selected from Mansoura Specialized Medical Hospital (MSMH) between April 2022 and February 2023. The patients were divided into two groups: fifty diabetic …

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Could Angiopioetin-1 & Angiopioetin-2 Be Considered A Predictor For Community Acquired Pneumonia Severity And Phenotypes, Magdy Mohamed Zedan, Nashwa Abusamra, Engy Osman, Rania Mohammed Emad Eldin Eldersy Jan 2025

Could Angiopioetin-1 & Angiopioetin-2 Be Considered A Predictor For Community Acquired Pneumonia Severity And Phenotypes, Magdy Mohamed Zedan, Nashwa Abusamra, Engy Osman, Rania Mohammed Emad Eldin Eldersy

Mansoura Medical Journal

Background: Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide and the role of biomarkers in pneumonia has been evaluated in many clinical areas. Angiopoietin-1 and Angiopoietin -2 are glycoproteins that play role in vascular development, angiogenesis, and permeability. Aim: To conduct a trial for phenotyping and endotyping of pneumonia using Angiopoietins-1 and Angiopoietin -2. Subjects and methods: This case-control study included 30 cases and 29 controls of matched age and sex. to investigate Angiopioetin-1 & -2 serum levels in both groups and then evaluated the possible association between serum Angiopoietin -1&-2 in different pneumonia phenotypes. Results: …

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Factors Affecting In-Hospital Mortality After Sudden Cardiac Arrest In The Emergency Department: A Retrospective Cohort Study, Erkan Boğa, Abdullah Algın Jan 2025

Factors Affecting In-Hospital Mortality After Sudden Cardiac Arrest In The Emergency Department: A Retrospective Cohort Study, Erkan Boğa, Abdullah Algın

Mansoura Medical Journal

Giriş: Ani kalp hastalıkları (SCA), özellikle acil serviste (AS) yüksek hastane içi ölüm tutarları ve önemli bir tıbbi acil durumları. Prognostik bilgilerin belirlenmesi, sonuçların değiştirilmesi için çok önemlidir. Amaç: Acil serviste SCA'lı hastane içi ölümle sağlanan klinik ve demografik oranların belirlenmesi. Yöntemler: Bu retrospektif kohort çalışmaları Ocak 2023 ile Aralık 2024 arasında üçüncü basamaktaki bir hastanenin AS'sinde SCA'nın 345 yıl boyunca geçirdiği süre dahil edildi. Demografik özellikler, türü olmayan yayılma, durma özellikleri, resüsitasyon süresi, laboratuvar gelişimi ve patoloji durumuyla ilgili veriler toplandı. Bağımsız ölüm öngörmelerini belirlemek için lojistik regresyon kaydı. Sonuçlar: Hastane içi ölüm %38,3 idi. Çok değişkenli analiz, resüsitasyon …

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Aprepitant Ameliorates Cyclophosphamide-Induced Testicular Toxicity In Mice Via Suppression Of P38 Mitogen-Activated Protein Kinase, Suzan Awad Abdelghany Morsy, Amira H. Eltrawy, Nehal Adel Khalil, Abd Elaziz Mm, Nourhan Mohamed Mohamed Saeed, Gehad M. Khamis Jan 2025

Aprepitant Ameliorates Cyclophosphamide-Induced Testicular Toxicity In Mice Via Suppression Of P38 Mitogen-Activated Protein Kinase, Suzan Awad Abdelghany Morsy, Amira H. Eltrawy, Nehal Adel Khalil, Abd Elaziz Mm, Nourhan Mohamed Mohamed Saeed, Gehad M. Khamis

Mansoura Medical Journal

Background: While cyclophosphamide (CP) is a commonly used immunosuppressant and anticancer drug, it has a high risk of testicular toxicity. The current study evaluated the protective and therapeutic actions of aprepitant (APR), a neurokinin-1 receptor blocker, against CP-induced testicular toxicity in mice and the role of oxidative stress and phosphorylated P38 mitogen-activated protein kinase (p-P38 MAPK) in this action.Methods: Forty male mice were assigned to four groups: control (vehicle only), CP-induced testicular toxicity (single 200 mg/kg intraperitoneal CP dose), APRprotected (20 mg/kg/day APR starting one day before CP, continued for 30 days), and APR-treated (same APR dose starting one hour …

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Relation Between Serum Vitamin D Level And Disease Activity In Rheumatoid Arthritis, Mohamed Hussein Salem, Nahed Abdullah Hassan, Adel Ibrahim Abdelsalam, Fatma Hamdy Jan 2025

Relation Between Serum Vitamin D Level And Disease Activity In Rheumatoid Arthritis, Mohamed Hussein Salem, Nahed Abdullah Hassan, Adel Ibrahim Abdelsalam, Fatma Hamdy

Mansoura Medical Journal

Background The role of vitamin D in the pathogenesis of rheumatoid arthritis is controversial. This study aims to assess the relation between vitamin D level and rheumatoid arthritis disease activity. Patients and methods This study was conducted on 80 rheumatoid arthritis (RA) patients beside 40 healthy persons. Vitamin D level was assessed in all participants. Rheumatoid activity was assessed using DAS28 (disease activity score). RA patients were classified according to DAS 28 into two groups: active group and remission group. Results The median for vitamin D level in RA group was 23.5ng/ml. There was no statistically significant difference in serum …

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Ultrasonic Criteria For The Selection Of Rib Graft For Laryngotracheal Reconstruction, Mohamed Abdulaziz Farah, Hazem Emam Amer, Ahmed Abdelfattah Elsobki, Mahitab M. Rashad Ghoneim, Ahmed Abdoo Elzhzahy Jan 2025

Ultrasonic Criteria For The Selection Of Rib Graft For Laryngotracheal Reconstruction, Mohamed Abdulaziz Farah, Hazem Emam Amer, Ahmed Abdelfattah Elsobki, Mahitab M. Rashad Ghoneim, Ahmed Abdoo Elzhzahy

Mansoura Medical Journal

Background Laryngotracheal reconstruction (LTR) is a well-established surgical procedure for the management of pediatric subglottic stenosis, with rib cartilage grafts. This study was conducted to evaluate preoperative and intraoperative discrepancies of rib graft used in laryngotracheal reconstruction using ultrasonic criteria in terms of their height, thickness, and length. Methods This prospective cohort study was conducted on 10 pediatric patients who underwent LTR at Mansoura University Hospitals. Preoperative ultrasonography was performed on the right 4th, 5th, and 6th rib cartilages, measuring height, thickness, and length. These measurements were then directly compared with intraoperative dimensions of the harvested cartilage. Results There was …

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The Association Between Stress-Related Disorders And Chronic Pelvic Pain Syndrome In Males: A Narrative Review, Abdinur Jama Farah, Mohammed Hegazy Abdulhalem, Wafaa Abdel-Hakim El-Bahaey, Ahmed Sobhy El Hefnawy Jan 2025

The Association Between Stress-Related Disorders And Chronic Pelvic Pain Syndrome In Males: A Narrative Review, Abdinur Jama Farah, Mohammed Hegazy Abdulhalem, Wafaa Abdel-Hakim El-Bahaey, Ahmed Sobhy El Hefnawy

Mansoura Medical Journal

Background Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) in males is a multifactorial clinical syndrome with significant impact on quality of life (QoL). Objective To explore the link between psychological stress and chronic pelvic pain in males through reviewing the relevant articles in CPPS literature. Review summary CPPS in males is a complex condition marked by persistent pelvic pain, urinary symptoms, and sexual dysfunction without identifiable infection or pathology. Its unclear etiology and significant impact on quality of life make it a challenging clinical problem. Growing evidence suggests that psychological stress plays a key role in symptom onset and persistence by …

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Evaluation Of Serum Ischemia Modified Albumin Level In Male With Androgenic Alopecia, Eman Elnigomy Mahmoud Elnigomy, Fawzia Ameen Saafan, Noha Mohamed Sherif Salah, Mohammed Samir Sultan Jan 2025

Evaluation Of Serum Ischemia Modified Albumin Level In Male With Androgenic Alopecia, Eman Elnigomy Mahmoud Elnigomy, Fawzia Ameen Saafan, Noha Mohamed Sherif Salah, Mohammed Samir Sultan

Mansoura Medical Journal

Introduction Androgenic alopecia (AGA) is the most common type of progressive hair loss in men, influenced by genetic and hormonal factors. Recent studies suggest that oxidative stress may play a role in its pathogenesis. Serum ischemia-modified albumin (IMA), a biomarker of oxidative stress, could provide insights into disease activity and severity in AGA patients. Aim The purpose of this study was to evaluate serum level of ischemia-modified albumin in male patient with androgenetic alopecia in comparison with healthy control. Patients and Methods This case-control study included 45 male patients with androgenetic alopecia and 45 age- and sex-matched healthy controls, recruited …

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Outcomes Of Expansion Sphincter Pharyngoplasty In Multilevel Lateral Pharyngeal Wall Collapse In Obstructive Sleep Apnea, Esraa Moustafa, Hisham Atef Ebada, Ahmed El-Sobki, Mohamed Mostafa Elsaher Jan 2025

Outcomes Of Expansion Sphincter Pharyngoplasty In Multilevel Lateral Pharyngeal Wall Collapse In Obstructive Sleep Apnea, Esraa Moustafa, Hisham Atef Ebada, Ahmed El-Sobki, Mohamed Mostafa Elsaher

Mansoura Medical Journal

Background: since its introduction in 2006, Since its introduction, expansion sphincter pharyngoplasty (ESP) has demonstrated significant efficacy in the management of pharyngeal collapse among patients with obstructive sleep apnea syndrome (OSAS). The aim of the current study is to investigate the effectiveness of ESP in multi-level pharyngeal wall collapse in patients with OSAS. Methods: This prospective study was conducted in the Otorhinolaryngology Department, Faculty of Medicine, Mansoura University, Egypt over 1.5 years (June 2023 – December 2024). The study included 29 patients with OSAS who underwent ESP to manage multilevel pharyngeal wall collapse. The outcomes were evaluated based on the …

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Interplay Between Amiodarone And Statins: Experimental Evidence Of Synergistic Hepatotoxicity, Hager Zaki Elghareb, Abdel-Motaal M. Fouda, Mohamed Mahmoud Elhadidi, Ahmed Abdel-Monem Elmetwally Jan 2025

Interplay Between Amiodarone And Statins: Experimental Evidence Of Synergistic Hepatotoxicity, Hager Zaki Elghareb, Abdel-Motaal M. Fouda, Mohamed Mahmoud Elhadidi, Ahmed Abdel-Monem Elmetwally

Mansoura Medical Journal

Background: Drug-induced liver injury (DILI) continues to be a main contributor to acute liver failure. So, this study aimed to investigate interactions between amiodarone and atorvastatin concerning hepatic safety, due to increasing clinical practice of their combination for optimal arrhythmia control. Methods: Forty male Sprague Dawley rats were randomly divided into four groups (10 in each group). Group 1 was control group receiving normal saline. Group 2 received Amiodarone-only \ (administered 30 mg/kg/day orally). Group 3 received Atorvastatin only (administered 10 mg/kg/day orally). Group 4 received combination of both amiodarone and atorvastatin in same previous doses. All drugs were dissolved …

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Study Of Heat Shock Protein 70 In Serum Of Cancer Breast Patients, Dina Adel Denewer, Fatma Abbas Auf, Khaled M. Abdelwahab, Mona Elwassefy Jan 2025

Study Of Heat Shock Protein 70 In Serum Of Cancer Breast Patients, Dina Adel Denewer, Fatma Abbas Auf, Khaled M. Abdelwahab, Mona Elwassefy

Mansoura Medical Journal

Background Breast cancer (BC) is the most frequent malignancy affecting women worldwide. Heat shock proteins (HSPs) are a family of proteins that are important for the maintenance of cell homeostasis. HSPs have been overexpressed in many tumours, including BCs, lung, gastric, ovarian, endometrial and colon Aim To evaluate the relation between serum levels of HSP70 and BC in Egyptians and its impact on tumour characteristics and different histopathological types of BC. Methods This a case-control study conducted on 70 cases of newly diagnosed BC and the control group included 19 apparently healthy age and sex matched subjects. Full clinical examination …

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Relationship Between Down Syndrome And Attention Deficit Hyperactivity Disorder And The Role Of Fkbp5 Gene: A Review Of Current Evidence, Israa A. Elsawi, Dina Salama Abd-Elmagid, Doaa Shahin, Mohamed Rizk Khodair, Sohier Yahia Jan 2025

Relationship Between Down Syndrome And Attention Deficit Hyperactivity Disorder And The Role Of Fkbp5 Gene: A Review Of Current Evidence, Israa A. Elsawi, Dina Salama Abd-Elmagid, Doaa Shahin, Mohamed Rizk Khodair, Sohier Yahia

Mansoura Medical Journal

The most prevalent chromosomal disorder is Down syndrome (DS). Neurodevelopmental disorders are highly associated with Down syndrome, such as attention deficit hyperactivity disorder (ADHD). Down syndrome is also distinguished by intellectual disability and developmental delays, with many affected individuals presenting manifestations of ADHD like inattention or hyperactivity. Differentiating ADHD from overlapping DS-related cognitive deficits remains a diagnostic dilemma. The FKBP5 gene, particularly the rs7748266 polymorphism, has been implicated in modulating stress response pathways linked to ADHD susceptibility. This review summarizes the relationship between DS and ADHD and explores the emerging role of FKBP5 rs7748266 in this context. This may later …

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Comparison Of The Efficacy Of Topical Cetirizine 1% Versus Topical Minoxidil 5% Solution In Treatment Of Male Androgenetic Alopecia, Hadeer Samy Abd-Elfattah, Bothaina Mahrous Ghanem, Farid Abd-Elreheim Badria, Mohammed Samir Sultan Jan 2025

Comparison Of The Efficacy Of Topical Cetirizine 1% Versus Topical Minoxidil 5% Solution In Treatment Of Male Androgenetic Alopecia, Hadeer Samy Abd-Elfattah, Bothaina Mahrous Ghanem, Farid Abd-Elreheim Badria, Mohammed Samir Sultan

Mansoura Medical Journal

Background: Androgenetic alopecia (AGA) is a common form of non-scaring hair loss characterized by extensive miniaturization of scalp hair follicles. Minoxidil is a standard topical treatment. Cetirizine, an antihistamine with anti-inflammatory properties, may be beneficial by modulating prostaglandins—specifically by inhibiting PGD2 and promoting PGE2, both of which have essential roles in hair cycle regulation. Aim: To compare the efficacy and safety of topical cetirizine 1% versus minoxidil 5% in treating male AGA. Patients and Methods: Forty male patients were randomly allocated in this randomized controlled study to receive topical cetirizine 1% or minoxidil 5%. Clinical photographs and dermoscopic evaluations were …

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Cyclooxygenase-2 Gene Variant In Egyptian Patients With Type 2 Diabetes Mellitus With Correlation To Lipid Profile And Markers Of Oxidative Stress, Shereen A. Mourad, Mohammed M. El Arman, Abeer Mesbah, Amany R. Youssef, Tarek Gouda, Hyam Sameh Nada, Doaa A. El-Hanafy Jan 2025

Cyclooxygenase-2 Gene Variant In Egyptian Patients With Type 2 Diabetes Mellitus With Correlation To Lipid Profile And Markers Of Oxidative Stress, Shereen A. Mourad, Mohammed M. El Arman, Abeer Mesbah, Amany R. Youssef, Tarek Gouda, Hyam Sameh Nada, Doaa A. El-Hanafy

Mansoura Medical Journal

Background: Cyclooxygenase-2 (COX-2) is an enzyme responsible for the conversion of arachidonic acid into prostaglandins. Despite previous studies, there is controversy considering the exact role of COX-2 in the pathogenesis of type 2 diabetes mellitus (T2DM) and its related adverse cardiovascular events. We aimed to examine the association between COX-2 rs20417 genetic polymorphism with increasing susceptibility to T2DM and whether it enhances the development of cardiovascular complications in T2DM. Methods: A total of 244 individuals were recruited, including 164 T2DM patients (further subdivided into uncomplicated and cardio-complicated cases) and 80 healthy control subjects. The different genotypes for the COX-2 rs20417 …

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Evaluation Of Safety And Efficacy Of Autologous Platelet-Rich Fibrin In The Treatment Of Psoriasis Vulgaris, Hajar Esamelddin, Maha Elgyyar, Mohamed Sultan Jan 2025

Evaluation Of Safety And Efficacy Of Autologous Platelet-Rich Fibrin In The Treatment Of Psoriasis Vulgaris, Hajar Esamelddin, Maha Elgyyar, Mohamed Sultan

Mansoura Medical Journal

Background: Psoriasis is a chronic, immune-mediated dermatosis characterized by dysregulated cutaneous immunity. Platelet-rich fibrin (PRF), an autologous biomaterial concentrated with immunomodulatory cytokines and growth factors, presents a potential novel therapeutic approach by modulating localized inflammatory pathways. Objective: This study aimed to assess the efficacy and safety of a topical and intralesionally autologous PRF protocol in patients with localized plaque psoriasis. Methods: In a prospective single-arm trial, sixty adults with mild-to-moderate localized plaque psoriasis (BSA ≤10%, PASI ≤10) were enrolled. PRF was prepared from peripheral blood via low-speed centrifugation without anti-coagulant. Treatment involved bi-weekly intralesionally injections and topical massage of the …

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Comparison Of Baumgaertner Reduction Quality Criteria , Chang Criteria And Ap3×Ml3 Classification And Their Ability To Predict Mechanical Complications Of Trochanteric Fractures Fixed With Proximal Femoral Nail, Amr Elhadidy Elhadidy, Ahmed Abdelbadie Ibrahim, Sallam Ibrahim Fawzy, Ehab Youssef Hassanin Jan 2025

Comparison Of Baumgaertner Reduction Quality Criteria , Chang Criteria And Ap3×Ml3 Classification And Their Ability To Predict Mechanical Complications Of Trochanteric Fractures Fixed With Proximal Femoral Nail, Amr Elhadidy Elhadidy, Ahmed Abdelbadie Ibrahim, Sallam Ibrahim Fawzy, Ehab Youssef Hassanin

Mansoura Medical Journal

Background Trochanteric fractures are common injuries among the elderly. Despite advances in fixation with proximal femoral nails (PFN), Mechanical complication remain significant. Several reduction quality systems have been proposed, but their predictive value and reproducibility remain debated. Aim To evaluate and compare the predictive value and reproducibility of Baumgaertner Reduction Quality Criteria (BRQC), Chang Reduction Quality Criteria (CRQC), and AP3×ML3 classification in patients with AO Foundation/Orthopaedic Trauma Association (AO/OTA) 31-A1 and 31-A2 trochanteric fractures fixed with PFN. Methods A prospective observational study was conducted on 146 patients with 31-A1 and A2 trochanteric fractures treated by PFN. Postoperative radiographs were assessed …

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Application Of The Papanicolaou Society Of Cytopathology (Psc) System For Reporting Endoscopic Ultrasound-Guided Fine-Needle Aspiration (Eus-Fna) Of Pancreatic Lesions, Sara Saad Abd El-Razik, Rehab Talaat El-Desoky, Khadiga Mohamed Ali, Amal Abd El Hafez Jan 2025

Application Of The Papanicolaou Society Of Cytopathology (Psc) System For Reporting Endoscopic Ultrasound-Guided Fine-Needle Aspiration (Eus-Fna) Of Pancreatic Lesions, Sara Saad Abd El-Razik, Rehab Talaat El-Desoky, Khadiga Mohamed Ali, Amal Abd El Hafez

Mansoura Medical Journal

Background: The Papanicolaou Society of Cytopathology (PSC) Reporting System presented a six-category classification system to stereotype the pathological clarification of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) samples. This study aimed to evaluate the accurateness of the PSC system in interpreting and reporting EUS-FNA of pancreatic lesions. Methods: A retrospective study with inter-observer analysis was performed on cytological samples got from patients who experienced EUS-FNA for pancreatic lesions from January 2018 to December 2022. Smears were observed by pathologists who were blinded to the final radiologic and pathologic data, applied the criteria of PSC System. Statistical examination was performed. Results: The study …

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Role Of Calbindin2 In Male Infertility With Oligozoospermia And Asthenoteratozoospermia, Ashraf H. A. Hassan, Adel A. E. Zalata, Sherif R. Ismail, Hebatullah Ahmed Elsayed Jan 2025

Role Of Calbindin2 In Male Infertility With Oligozoospermia And Asthenoteratozoospermia, Ashraf H. A. Hassan, Adel A. E. Zalata, Sherif R. Ismail, Hebatullah Ahmed Elsayed

Mansoura Medical Journal

Introduction: Male infertility may account for almost half of all cases of infertility. This is commonly linked to compromised sperm characteristics, such as shape, concentration, and motility. Recent studies have suggested a role for calcium-binding proteins, including Calbindin 2 (CALB2), in spermatogenesis and male reproductive function. Aim: The purpose of this study was to assess the association between male infertility in cases of oligozoospermia and asthenoteratozoospermia and seminal Calbindin 2 levels. Patients and Methods: A case-control study was performed on 90 men (45 infertile, 45 fertile controls). Semen parameters, oxidative stress, hormone levels, DNA fragmentation, acrosin activity, and seminal CALB2 …

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Clinical And Radiological Outcomes Of Posterior Malleolar Fractures Fixation Through Posterolateral Approach: A Prospective Case Series Study, Mohammed Abdulrafei Farag, Ahmed Elsayed Elhawary, Ahmed Salah-Eldeen Zaghloul Jan 2025

Clinical And Radiological Outcomes Of Posterior Malleolar Fractures Fixation Through Posterolateral Approach: A Prospective Case Series Study, Mohammed Abdulrafei Farag, Ahmed Elsayed Elhawary, Ahmed Salah-Eldeen Zaghloul

Mansoura Medical Journal

Background: Posterior malleolar fractures are frequently associated with other malleolar injuries and significantly affect ankle stability through the posterior tibiofibular ligament. CT imaging is vital for preoperative classification, fragment size measurement, and syndesmotic evaluation. Objective: To assess clinical and radiological outcomes of posterior malleolar fractures treated using the posterolateral approach. Methods: This prospective case series included 20 skeletally mature patients treated between March 2022 and January 2024. Preoperative evaluation included radiographs and CT scans for classification, fragment size, articular step-off, and syndesmotic injury. Postoperative reduction and alignment were assessed with X-ray and CT. Functional outcomes were evaluated at ≥6 months …

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