Medicine and Health Sciences Commons^™

Planned Changes To Nurse Leadership, Staffing And Skill-Mix: Impact On The Working Environment, Job Satisfaction And Intention To Leave, Noeleen Brady, Selena O'Connell, David Gilligan, Caoimhe Madden, Lisa Gannon, Victoria Howson, Jane E. Ball, Aileen Murphy, Peter Griffiths, Christine Duffield, P. Anne Scott, Vera J.C. Mc Carthy, Jonathan Drennan

Research outputs 2022 to 2026

Introduction: Job satisfaction and intention to leave have been consistently linked to the working environment. However, there are few studies of interventions for improving the environment or staff outcomes. Aim: To determine the impact of implementing a framework for safe nurse staffing on the environment and staff outcomes. This involved an assessment of required nursing hours per patient day, supernumerary nurse in charge and minimum 80:20 skill-mix, with intentional changes in staffing if required. Design: A pre-post observational design. Methods: This was a prospective observational study in six medical and/or surgical wards across three acute hospitals in Ireland. The outcomes …

Psychotropic Polypharmacy In Dementia: A Retrospective Analysis For People With Neuropsychiatric Symptoms Referred To An Australian Dementia Support Service, Mustafa Atee, Andrew Stafford, Daniel Whiting, Ya Ping Lee, Christopher Morrow, Guillaume Nyakaboyi, Ella Warnes, Thomas Morris

Research outputs 2022 to 2026

Background and Objectives: Despite their limited benefits and serious adverse effects, psychotropics remain frequently prescribed for neuropsychiatric symptoms (NPS) of dementia. Psychotropic polypharmacy, the use of two or more concomitant psychotropic medications, is therefore not recommended for people with dementia. The objectives of this study were to investigate the prevalence of psychotropic polypharmacy in Australians living with dementia whose caregivers sought external NPS support from Dementia Support Australia (DSA; the national provider of NPS support) and the association of psychotropic polypharmacy with their demographics and NPS characteristics. Methods: A retrospective cross-sectional study of a subset of DSA referrals at baseline …

Rapid Diagnosis Of Bacterial Vaginosis Using Machine-Learning-Assisted Surface-Enhanced Raman Spectroscopy Of Human Vaginal Fluids, Xin Ru Wen, Jia Wei Tang, Jie Chen, Hui Min Chen, Muhammad Usman, Quan Yuan, Yu Rong Tang, Yu Dong Zhang, Hui Jin Chen, Liang Wang

Research outputs 2022 to 2026

Bacterial vaginosis (BV) is an abnormal gynecological condition caused by the overgrowth of specific bacteria in the vagina. This study aims to develop a novel method for BV detection by integrating surface-enhanced Raman scattering (SERS) with machine learning (ML) algorithms. Vaginal fluid samples were classified as BV positive or BV negative using the BVBlue Test and clinical microscopy, followed by SERS spectral acquisition to construct the data set. Preliminary SERS spectral analysis revealed notable disparities in characteristic peak features. Multiple ML models were constructed and optimized, with the convolutional neural network (CNN) model achieving the highest prediction accuracy at 99%. …

The Changes In Health-Related Quality Of Life After Attending Cardiac Rehabilitation: A Qualitative Systematic Review Of The Perspective Of Patients Living With Heart Disease, Amineh Rashidi, Lisa Whitehead, Helena Halton, Lisa Munro, Ian Jones, Lisa Newson

Research outputs 2022 to 2026

Background Although the benefits of engaging in cardiac rehabilitation are well established, patient perceptions of the changes in their health-related quality of life are poorly documented. This systematic review synthesized qualitative studies on patients’ perspectives of change in their health-related quality of life after attending cardiac rehabilitation. Objective To identify and synthesize the best available evidence on the perspective of patients living with heart disease about the changes in their health-related quality of life after attending cardiac rehabilitation. Methods Eight databases were used to identify relevant papers published in English and peer-reviewed, and no date restrictions were considered for the …

The Physiological Consequences Of And Recovery Following The Australian Special Forces Selection Course, Angela C. Uphill, Kristina L. Kendall, Bradley A. Baker, Stuart N. Guppy, Hannah M. Brown, Michael Vacher, Bradley C. Nindl, G. Gregory Haff

Research outputs 2022 to 2026

This study aimed to determine the energy requirements, physiological consequences, and recovery rate from the Australian Special Forces Selection Course. Ninety-three male soldiers (mean ± SD, 28.1 ± 3.6 years, 1.81 ± 0.1 m, 85.1 ± 8.1 kg) vol-unteered for this study. Body composition via dual-energy X-ray absorptiometry, hormones and resting metabolic rate were assessed before, immediately after, and at 1, 3, 5, and 8 weeks post-course. Energy expenditure, assessed via doubly-labelled water during the first 10 days of the course significantly exceeded energy intake (expenditure: 7680 ± 1095 kcal. day–1, in-take: 3859 ± 704 kcal. day– 1). Body mass …

Web-Based Application For Reducing Methamphetamine Use Among Aboriginal And Torres Strait Islander People: Randomized Waitlist Controlled Trial, Rachel Reilly, Rebecca Mcketin, Federica Barzi, Tayla Degan, Nadine Ezard, Katherine Conigrave, Julia Butt, Yvette Roe, Handan Wand, Brendan Quinn, Wade Longbottom, Carla Treloar, Adrian Dunlop, James Ward

Research outputs 2022 to 2026

Background: Digital interventions can help to overcome barriers to care, including stigma, geographical distance, and a lack of culturally appropriate treatment options. “We Can Do This” is a web-based app that was designed with input from cultural advisors and end users to support Aboriginal and Torres Strait Islander people seeking to stop or reduce their use of methamphetamine and increase psychosocial well-being.

Objective: This study aimed to evaluate the effectiveness of the “We Can Do This” web-based app as a psychosocial treatment for Aboriginal and Torres Strait Islander people who use methamphetamine.

Methods: The web app was evaluated using a …

Weight Stigma Amongst Nurses And Nursing Students: A Scoping Review Of Direct And Comparative Evidence, Mahshid Fonoudi, Beverley Ewens, Amanda Towell-Barnard

Research outputs 2022 to 2026

Aim: To map both direct and comparative research on weight stigma amongst nurses and nursing students by identifying the extent, range and nature of studies and identify the gaps in this area. Design: Scoping review, following the Joanna Briggs Institute (JBI) guidelines. Data Sources: Seven databases including MEDLINE, Web of Science, CINAHL, Embase, Scopus, PsycINFO and Cochrane Library, in addition to Google Scholar and Open Access Theses and Dissertations were systematically searched in August 2023. Methods: Inclusion criteria comprised nurses or nursing students as participants, weight stigma as the concept and any context. After uploading all search results into EndNote …

Better Sleep Hygiene Is Associated With Better Sleep Health In Mining Shift Workers In Australia, Philipp Beranek, Ian C. Dunican, Travis Cruickshank, Mitchell Turner

Research outputs 2022 to 2026

Australia's mine sites are largely situated in remote locations and operate around the clock. Many shift workers fly to site, where they work 12-hr shifts and sleep in camp accommodation before they return home for the period rostered off work. Mining shift workers experience poor sleep, yet limited research is available on contributing factors. This study investigated, for the first time, the relationship between the sleep health and sleep hygiene in this population. A survey was disseminated to shift workers in the mining industry, utilising a cross-sectional study design. The Sleep Health Index and Sleep Hygiene Index questionnaires were used …

Effectiveness, Acceptability, And Cost-Effectiveness Of Digital Health Interventions For Diabetes Self-Management In Adults With Or Without Hypertension: An Umbrella Review Protocol, Min Zhang, Jiahui Ge, Xinrong Yu, Tian Wang, Fenglan Wang, Madalo Gloria Kalero Kuchawo, Li Ge

Research outputs 2022 to 2026

Objective: This review will synthesize evidence on the effectiveness, acceptability, and cost-effectiveness of digital health interventions in implementing and maintaining effective self-management among adults (≥ 18 years) with diabetes, with or without comorbid hypertension. Introduction: Diabetes and hypertension are becoming the most challenging global health burdens. Growing evidence underscores the effectiveness of digital health interventions for diabetes and hypertension. However, it is unclear whether these strategies can be recommended to improve diabetes self-management among adults with or without hypertension in primary health care. Inclusion criteria: We will include systematic reviews (with or without meta-analysis) examining the effectiveness, acceptability, and cost-effectiveness …

Facilitators, Barriers, And Strategies For Supporting Shared Decision-Making With People With Intellectual Disability: A West Australian Primary Healthcare Professional Perspective, Kathryn Teale, Abigail Lewis, Rachel Skoss

Research outputs 2022 to 2026

Background: Shared decision-making between patients and primary healthcare professionals positively impacts health outcomes. However, people with intellectual disability face additional barriers and require supported shared decision-making (SSDM) to participate. Little is known about how healthcare professionals use SSDM with this population. This paper explores the facilitators and barriers experienced, and strategies/resources employed by healthcare professionals working with people with intellectual disability. Method: Ten purposively sampled primary healthcare professionals participated in semi-structured interviews. This descriptive qualitative study used content analysis. Findings were compared with a proposed model of factors influencing triadic (the person with intellectual disability, their caregiver and the healthcare …

From The Icu Bedside: Applying The Transnational Clinical Academic Doctorate Lens To A Clinically Embedded Phd Journey, Gideon U. Johnson

Research outputs 2022 to 2026

Aim: To critically reflect on a transnational, clinically embedded doctoral journey undertaken during and after the COVID-19 pandemic, and to draw conceptual and systemic lessons for doctoral education and clinical academic nursing pathways. Background: Reflective accounts of doctoral study exist, yet few examine practice-based PhDs conducted across different countries and health systems during a global crisis. This paper analyses one such pathway—enrolment at an Australian university with research embedded within the UK National Health Service—to explore resilience, identity formation, mentorship ecologies and organisational conditions that support or hinder clinical academic development. Method: Using analytic autoethnography and reflective case study logic, …

Navigating Ethical Complexities In Health Education: Exploring Challenges In Teaching Food And Health, E. Oljans, M. Quennerstedt, D. Barker, A. Caldeborg, V. Varea

Research outputs 2022 to 2026

Teaching food and health may be challenging, especially in classrooms where young people from different cultures, ethnicities, and religions meet. This article explores teachers’ navigation of ethical complexities when teaching food and health in classrooms with immigrant students. Five didactical strategies were identified: (1) The educare strategy, (2) The tiptoeing strategy, (3) The collegial support strategy, (4) The intercultural strategy, and (5) The pluralistic strategy. These didactical strategies are embedded in various educational settings. Our results demonstrate that a further focus on ethical and intercultural competence should be carefully supported and implemented in teacher education and continual professional development programmes …

Sorghum And Sorghum-Based Products: Nutritional Composition, Prebiotic Potential And Health Benefits In Gut Microbiota Interactions, W. M.A.D.Binosha Fernando, Rasheed A. Abdulraheem, Kalmee Pramoda Kariyawasam, Amal Sudaraka Samarasinghe, W. M.Kendrea T. Fernando, Hannah Barnes, Malina Robertson, D. P.W. Jayatunga, B. G.D.N.K. De Silva, Vijay Jayasena

Research outputs 2022 to 2026

Sorghum (Sorghum bicolor L.) is a member of the Poaceae family and is the fifth most important crop globally. Sorghum grains (SGs) are rich in health-promoting macro- and micronutrients and phytochemicals. SGs are commonly consumed as food or as ingredients in food, especially in African countries. Therefore, food products such as ogi, bread and flour have been and are still being developed from SGs to provide nutritional and health benefits. However, the nutritional and prebiotic potential of SGs, especially the pigment pericarps, has not been fully exploited. This review describes micronutrients in different varieties of sorghum and the health benefits …

Towards Equitable Cancer Outcomes For Rural And Remote Communities: Reflections, Lessons And Recommendations, Anna Ugalde, Hannah Jongebloed, Charlene Wright, Helena Rodi, Anna Chapman, Skye Marshall, Drew Aras, Rebecca J. Bergin, Sophie Boffa, Anna Boltong, Michele Conlin, Fiona Crawford–Williams, Carl De Wet, Wasek Faisal, Lan Gao, Harry Gasper, Kate Gunn, Nicolas H. Hart, Theresa Hayes, Florian Honeyball, Elizabeth A. Johnston, Deme Karikios, Nicole Kiss, Lucy Leigh, Patricia M. Livingston, Carmel O'Kane

Research outputs 2022 to 2026

People living in rural and remote areas continue to face significant inequities in cancer outcomes compared to their metropolitan counterparts. Despite advances in cancer control, these disparities persist across the cancer trajectory. This personal view consolidates findings from our Equitable Cancer Outcomes for Rural and Remote Communities series, highlighting survival disadvantages, challenges in measuring and reporting rurality, barriers to implementing evidence-based interventions, and shortcomings in historical policy. We argue for place-based, system-level reform that genuinely partners with rural communities, leverages local strengths, and embeds rural voices in research, policy, and service delivery. Key recommendations include adopting a formal partnership position …

Improving Hpv Vaccine Rates For Aboriginal Young People Through A Social Media Campaign: An Interrupted Time Series, Natalie A. Strobel, Jocelyn Jones, Kim Gates, Simon L. Turner, Joanne E. Mckenzie, Daniel R. Mcaullay

Research outputs 2022 to 2026

Human papillomavirus (HPV) is a common sexually transmitted infection that can lead to HPV-related cancers such as cervical cancer and other cancers such as anal, vaginal, and penile cancer. HPV rarely produces symptoms and cannot be cured or treated; therefore, vaccination is essential to protect against HPV and HPV-related diseases. However, young Aboriginal and Torres Strait Islander (hereafter, respectfully, ‘Aboriginal’) people are not receiving their HPV vaccine dose, resulting in missed opportunities to be protected from HPV-related cancers. Health promotion is a critical way to empower people to take ownership over and control their health and is a core function …

Metadata Makes Big Data Useful For Ai/Ml-Ready, Equitable Pandemic Response, Sudarshan Anand, Miae Lee, Seshadri S. Vasan

Research outputs 2022 to 2026

While genomic data helps understand the pathogen and its evolution, patient metadata is critical to get the host side of the picture, so that the pandemic response is effective and equitable.

Clinical Relevance: We highlight the importance of patient stratification and metadata to help develop diagnostics, therapies and vaccines as the pathogen (virus) evolves.

When Descriptor Is Diagnosis: An Autoethnographic Response To The Medical Treatment Of Women With Vulvodynia, Josephine Taylor, Alexandra Ridgway

Research outputs 2022 to 2026

Women with chronic vulvar pain experience symptoms that can affect their everyday functioning. These women are often diagnosed with vulvodynia, defined as vulvar pain without a medical explanation lasting at least three months. Yet while vulvodynia is presented by medical authorities as a diagnosis it is, more accurately, a descriptor of the physical condition. As such it does not have the ability to explain what causes this vulvar pain and, consequently, cannot determine an appropriate treatment pathway for all patients. As women with vulvodynia (‘V women’), we use this article to highlight the issues posed by a descriptor camouflaging as …

Alexithymia And Impulsivity In Combat Sports – A Tale Of Three Measures, Craig A. Harms, Oliver R. Barley

Research outputs 2022 to 2026

The purpose of this study was to compare the psychometric properties of two measures of alexithymia – the Toronto Alexithymia Scale (TAS-20) and the Perth Alexithymia Questionnaire (PAQ) – as well as the Barratt Impulsiveness Scale 11 measure of behavioural impulsivity because the psychometric properties of these scales have not been established in athletes. As part of a larger study, 298 participants completed an online survey that included the TAS-20, PAQ, and BIS 11, as well personal- (age and gender) and sport-specific (primary combat sport and level of competition) demographic measures. A unidimensional model was retained for the TAS-20. A …

Community Perspectives On Spinal Cord Injury In Rugby Union: Facts And Fears, Nicole Merrick, Marelise Badenhorst, Ashlee Morgan, Lauren Fortington

Research outputs 2022 to 2026

Introduction: The sport of rugby union, henceforth rugby, is associated with a risk of spinal cord injury (SCI). Perceived risks can impact participation. Understanding community perspectives on rugby-related SCI may provide insight for addressing concerns around risk. The aim of this study was to explore community perspectives through social media discussion about SCI in rugby union. Methods: Posts about SCI in rugby union were identified using the advanced search function on Twitter. Data (content as original post, retweet, quote tweet and comments) were included if focused on Rugby Union and written in English. Inclusion dates (July 2018 to June 2019) …

Environmentally Persistent Free Radicals Lead To Selective Inhibition Of Cyp1 Monooxygenase Activities, And Increased Production Of Reactive Oxygen Species By Reaction Uncoupling, John Patrick Connick, Amari A. Stepter, George F. Cawley, Marilyn K. Eyer, Wayne L. Backes

School of Medicine Faculty Publications

This study focuses on the effect of Environmentally Persistent Free Radicals (EPFRs) on the P450 enzymes of the CYP1 family. EPFRs are a component of particulate pollutants, that are stable in the environment, but can generate free radicals, leading to oxidative stress and subsequent toxicity of the respiratory, cardiovascular, and immune systems once they enter an organism. The results show differences in the ability of EPFRs to inhibit CYP1-dependent substrate metabolism, with CYP1B1 being inhibited to the greatest extent. There also were differences in the ability of EPFRs to disrupt the POR•CYP1 complex, with CYP1B1 being the only form where …

Chronic Administration Of A Cannabis-Derived Mixture At An Antihyperalgesic Dose Does Not Significantly Enhance Hepatotoxicity Or The Development Of Metabolic Dysfunction-Associated Steatohepatitis In Male Mice, Kim B. Pedersen, Tomislav Jelesijevic, Tamara M. Morris, Sarah M. Melton, Ashley S. Henderson, John F. Glenn, Gregory J. Davenport, Martin J.J. Ronis, Peter J. Winsauer

School of Medicine Faculty Publications

Cannabis and cannabinoid mixtures have been linked to a variety of health benefits including pain mitigation, suppression of nausea produced by chemotherapeutic agents, anti-inflammatory effects, and effects on energy homeostasis, glucose, and lipid metabolism. The latter properties have led to the suggestion that these products could have therapeutic effects on the development of metabolic dysfunction-associated steatohepatitis (MASH) - a severe type of liver pathology in obese and diabetic patients. However, varying agonist and antagonistic properties of different cannabinoids on the endogenous cannabinoid system make prediction regarding hepatic effects and diet interactions difficult. The current study was designed to examine hepatic …

Multi-Modal Neo-Adjuvant Anti-Obesity Medications May Be More Effective Than Medically Supervised Weight Loss Or Glp-1 Therapy Alone In Preparing Bmi ≥ 70 Patients For Metabolic Surgery, Michael Kachmar, Florina Corpodean, Iryna Popiv, Kyle B. Lapenna, Denise M. Danos, Michael W. Cook, Brian A. Saunders, Jean J. Domercant, Vance L. Albaugh, Philip R. Schauer

School of Medicine Faculty Publications

Background/objectives: Optimizing patients with a body mass index (BMI) ≥ 70 kg/m² for metabolic surgery (MS) is challenging. However, pre-operative weight loss may be important for improving the safety of MS for these high-risk patients. Multi-modal anti-obesity medications (mmAOM) may enhance preoperative weight loss compared to non-pharmacologic medically supervised weight loss (NP-MSWL) or glucagon-like peptide-1 receptor agonist monotherapy (Mono-GLP-1) alone. Subjects/methods: This retrospective study analyzed 113 patients with BMI ≥ 70 kg/m² at a single metabolic disease treatment institute. Interventions/methods: Patients were categorized into NP-MSWL (n = 13), Mono-GLP-1 (n = 54), and mmAOM (n = 46) groups. The primary …

Investigating The Acceptability Of Modified Constraint-Induced Movement Therapy Among Stroke Survivors And Carers: A Qualitative Study, Ashan Weerakkody, Erin Godecke, Barby Singer

Research outputs 2022 to 2026

Purpose: To investigate the acceptability of modified constraint-induced movement therapy (mCIMT) among stroke survivors and carers within an early-supported discharge (ESD) service, and to inform further adaptations of the program to enhance acceptability. Methods: Qualitative study within a mixed methods process evaluation of mCIMT implementation. Semi-structured interviews were analysed using reflexive thematic analysis and mapped to the Capability, Opportunity, Motivation- Behaviour (COM-B) model. Results: Fifteen stroke survivors and ten carers participated. Five themes were generated and mapped to the COM-B. Participants attributed functional improvements to the program whilst also encountering several challenges with returning home after stroke (Capability- physical); the …

Enhancing Engagement In Cardiovascular Risk-Reducing Behaviors Through Motivational Text Messaging (Mtm) In An Underserved Population Of Memphis, Tennessee, Lindsey H. Dao

DNP Projects

Enhancing Engagement in Cardiovascular Risk-Reducing Behaviors Through Motivational Text Messaging (MTM) in an Underserved Population of Memphis, Tennessee

An Analysis Of Mental Health And Workplace Absenteeism, Kristin Marie Vrona

Graduate Research Theses & Dissertations

This dissertation examines the effect of mental health on own health-related absenteeism among employed adults in the United States, using data from the 2010–2014 Medical Expenditure Panel Survey (MEPS). The MEPS uniquely differentiates between absences due to one’s own health and those due to another person’s health, enabling causal estimation of individual-level factors influencing absence decisions.

The analysis incorporates both mental and physical health measures, including diagnostic indicators and self-reported general well being, which are used as proxies for severity that may affect both diagnosed and undiagnosed individuals. Results reveal a consistent pattern: individuals experiencing high psychological distress but lacking …

Hypnosis: An Evidenced Based Treatment, Gregory P. Brown

Psychiatry & Behavioral Health Faculty Research

Review of meta analyses and systemic review level studies of hypnosis in the treatment of anxiety, burnout, and depression.

Functional And Traditional Medical Management Of Endometriosis: An Integrative Review, Madison G. Daniels

Senior Honors Theses

Endometriosis, a progressive disease that affects many women worldwide, has been managed primarily through hormonal medication, pain management and surgical intervention. However, there is a growing desire among women to use more natural and holistic methods to control the progression of this disease as well as effectively manage the severe symptoms that accompany it. This integrative review examines the efficacy of functional management as compared to traditional medical management. The pathophysiology of each treatment method and provide statistical evidence as to its efficacy. The progression of the disease, symptom management, and related side effects are all taken into consideration in …

Perspectives On Demyelinating Disease: An Overview Of Multiple Sclerosis, Nathaniel Howard Williams

Senior Honors Theses

Multiple sclerosis (MS) is a demyelinating disease of central nervous system (CNS), primarily concerning oligodendrocytes, the myelinating cells of the CNS and the neurons that are ensheathed in myelin. MS is the most common demyelinating disease, affecting as many as 300,000 yearly in the United States alone. Much debate centers on whether MS onset is primarily caused by autoimmune reactions or intrinsic dysfunction in oligodendrocytes, which prompts an immune-mediated response. Those who review the current literature on MS may become quickly overwhelmed by the volume and variety of available material. The purpose of this review is to present a …

Cardiac Timing Effects On Response Speed Are Modulated By Blood Pressure But Not Heart Rate Variability In Healthy Young Adults, Xiao Yang, Catalina Roldan, Michael Gazzanigo, Yasmine Nabulsi, Fang Fang

Research and Infrastructure Service Enterprise (RISE) Faculty Publications

Cardiac timing effects reflect the dynamic interplay between interoceptive and exteroceptive processes. Human information processing tends to be facilitated during cardiac diastole and inhibited during systole, reflecting autonomic regulation and the neuromodulation by baroreceptor afferents. Thus, blood pressure (BP) and vagally-mediated heart rate variability (vmHRV) are potential modulators of those effects. Additionally, cognitive control appears to play a critical role in the processes. However, whether cardiac timing effects are influenced by those factors remains unclear. The present study aimed to clarify these relationships. Fifty-one healthy young adults completed three experimental sessions to assess BP, short-term HRV, and cardiac timing effects. …

Loneliness Associates With Endothelial Dysfunction In A Community-Based Cohort: A Pilot Study And Translational Approach, Yvonne Baumer, Brian A. Tirado, Lola R. Ortiz-Whittingham, Andrew S. Baez, Cristhian A. Gutierrez-Huerta, Laurel G. Mendelsohn, Abhinav Saurabh, Joshua A. Jacobs, Marcus R. Andrews, Valerie M. Mitchell, Billy S. Collins, Antwan Jones, Danielle M. Schwartz, Anca D. Dobrian, Michael V. Stanton, Tiffany M. Powell-Wiley

Department of Biomedical and Translational Sciences Faculty Publications

Loneliness is known to be an important contributor to cardiovascular disease (CVD). However, little is known about the impact of loneliness on endothelial barrier integrity, a crucial hallmark of CVD development and progression. In this study, we aimed to investigate how loneliness might impact the endothelium. We found greater perceived loneliness associated with the product of circulating epinephrine and TNFα (E/T), which, in turn, associated with lower VE-cadherin on endothelial cells in an ex vivo experiment. Additionally, circulating plasma levels of soluble VE-cadherin were associated significantly with subclinical CVD. To explore the mechanistic aspects of these associations, we measured the …