Medicine and Health Sciences Commons^™

Male Infertility: From Root Causes To Modern Interventions, Scott Bowser

Capstone Showcase

Male infertility impacts up to 15% of men and contributes significantly to worldwide infertility.1 A multifaceted issue with etiologies from before, after or during spermatogenesis. It includes hypothalamic-pituitary-gonadal axis dysfunction, genetic abnormalities, congenital malformations, systemic illnesses and environmental factors.2 The evaluation of male infertility considers contributing factors and interconnections with broader health issues. Pre-testicular factors discussed include Klinefelter syndrome, Y-chromosome microdeletions, hyperprolactinemia, thyroid dysfunction, obesity, diabetes mellitus, nutrition, pharmaceuticals and lifestyle. Problems within the testicles are cryptorchidism, varicoceles, infections, neoplasms, trauma and anti-sperm antibodies. Common post-testicular reasons are cystic fibrosis, erectile dysfunction, premature ejaculation, hypoactive sexual desire, vasectomies and retrograde …

Structural And Interpersonal Determinants Of Covid-19 Vaccine Uptake In Vulnerable Populations Of The United States, Alyea Wood

Capstone Showcase

Since its introduction in late 2020, the uptake of the COVID-19 vaccine has had the lowest rates in marginalized populations like minorities, elderly, and those of low socioeconomic status. Decreased rates of vaccination uptake in these groups has resulted in increased burden of disease and subsequently higher rates of hospitalization and death. Many inequities in poor COVID-19 health outcomes can be explained by examining common predictive factors that determine vaccination rates in these United States populations. This special article research aims to explore these various predictive factors with the goal to provide targeted strategies to boost COVID-19 vaccination rates, especially …

Probiotics In Clinical Practice: Mechanisms, Applications, And Evidence-Based-Use, Christopher Dimatteo

Capstone Showcase

Probiotics, are live microorganisms that can provide health benefits when consumed in the right amounts, have gained attention as potential therapies for a range of conditions. This article examines the current understanding of probiotics, focusing on how they work, the conditions they might help manage, and the challenges that come with probiotic use. Research shows that probiotics can support gut health by balancing the microbiome, strengthening the intestinal barrier, and influencing the immune system. They have shown promise in conditions like irritable bowel syndrome, antibiotic-associated diarrhea, and some inflammatory disorders. However, their effectiveness depends on the specific strain used, and …

Adjusting To The Rising Prevalence Of Colorectal Cancer Amongst Young Adults, Stephanie Wang

Capstone Showcase

Colorectal Cancer (CRC) is the second most prevalent cause of cancer-related death, with the highest incidence in middle-age and elderly populations [1]. However in America, there is a rising incidence rate of colorectal cancer amongst individuals under 45 years of age, leading to early-onset colorectal cancer (EOCRC [2]). From all cancers studied from 2010-2019, gastrointestinal cancers had an increase in incidence rate of 14.80%, making it the fastest-growing among all early-onset cancers [2]. Patients with EOCRC have a higher likelihood of misdiagnosis and metastasis, leading to higher rates of mortality [1]. Additionally, many patients suffering from EOCRC are uninsured minority …

Eccentric-Emphasis Exercise Program For Supraspinatus Partial Tear In Retired Police Officer An Intervention Case Report, German Eduardo Isea Fernandezx

Capstone Showcase

Abstract

Background and Purpose: Eccentric exercise has been shown to reduce pain in patients with multiple comorbidities, orthopedic surgeries, and neurologic conditions, while providing safety for greater loading during resistance training. The purpose of this case report is to describe changes in function and pain of a patient with a partial rotator cuff tear, following rehabilitation exercises focusing on eccentric action.

Case Description: A 65 y/o retired police male officer who presented right shoulder pain secondary to a partial tear of the supraspinatus tendon. The case reported mild to severe pain under the visual analog scale (VAS) of 75mm that …

Functional Recovery Of A Patient In Her Home Environment Following A Stroke Using Proprioceptive Neuromuscular Facilitation And Task-Specific Training: A Case Report, Andrea L. Crawford-Perry

Capstone Showcase

Abstract Background and Purpose: Stroke is a growingly common disability that affects an individual’s bodily function, activity and participation levels and thus impacts the whole livelihood of that individual. Proprioceptive Neuromuscular Facilitation (PNF) and Task-specific Training have been shown to improve the overall functional recovery of a patient and affect neuroplasticity. Most studies tend to compare the individual effect of these techniques; hence the purpose of this case report is to describe how both PNF and task-specific training are used to improve the functional recovery of a patient in her home environment following an acute stroke. Case Description: The patient …

Effects Of Tecar Therapy With Conventional Physical Therapy In Patient With Knee Osteoarthritis (Oa): A Case Report, Mitzi Joy O. Fernandez

Capstone Showcase

Background and Purpose: Transfer energy capacitive and resistive (TECAR) therapy is a relatively new form of technology used as an adjunct for the rehabilitation of musculoskeletal conditions. Several studies have found its beneficial effects in reducing pain and improving quality of life in numerous orthopedic conditions. Knee osteoarthritis (OA) is one of the most common causes of global disability and pain, with accompanying complaints of morning stiffness, limitation of motion, knee buckling, swelling and inflammation, muscle weakness, functional limitations, and bony enlargement that affects the activities of daily living, occupation, and leisure activities. The purpose of this case report is …

Recommendations For Diagnosis And Treatment Of Functional Hypothalamic Amenorrhea In Females Of Reproductive Age, Monica Foster

Capstone Showcase

Hypothalamic amenorrhea (HA) accounts for approximately 30% of total cases of secondary amenorrhea in women of reproductive age. HA is defined as the absence of menses due to inadequate secretion of gonadotropin-releasing hormone (GnRH) by the hypothalamus leading to lack of secretion of gonadotropins from the anterior pituitary gland and steroid hormones from the ovaries. This feedback loop, called the hypothalamic-pituitary-gonadal (HPG) axis, regulates reproductive activity in animals and humans. When this system is disrupted in females due to a hormonal imbalance, menstrual abnormalities may emerge. Functional hypothalamic amenorrhea (FHA) is defined as the absence of menses in which anatomic …

Ketamine Infusion Treatment For Depression, Isabella Schwing

Capstone Showcase

Depression remains a significant public health challenge in the U.S., affecting millions of adults and contributing to both psychological and financial burdens. Major depressive disorder impacts approximately 14.5 million U.S. adults, with about 30% of cases classified as treatment-resistant depression. Traditional antidepressant therapies, including selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors, often have delayed onset and limited efficacy, leaving a substantial portion of patients without adequate relief. Given these limitations, there is an urgent need for alternative treatment options.

Recent research has highlighted ketamine as a promising intervention for Major Depressive Disorder and Treatment Resistant Depression. Initially identified as …

Caspases Protect Against Hyperglycemia Induced Necroptosis-Like Cell Death In Brain Endothelial Cells, Aleena S. Mathew

Theses and Dissertations

Acute diabetes characterized by high spikes in blood glucose levels in association with severe hyperglycemia can lead to an increased risk of ischemic stroke in the brain. To better understand high blood glucose levels, hyperglycemia, in the brain we explored its effects on endothelial cells. Endothelial cells line the inner walls of blood vessels and are directly impacted in hyperglycemia. Brain endothelial cells are a major component of the blood brain barrier (BBB) which tightly regulates the brain’s microenvironment. The type of cell death such as apoptosis, caspase dependent, or necroptosis, caspase independent, can exacerbate diabetes associated complications. There is …

Social Rejection, Isolation, And Substance Use Disorders: A Neurobiological Defense Of Social Network Intervention In Single-Site Housing First, Victoria Eichel

Scripps Senior Theses

Abstract

Introduction: Rising rates of homelessness in the United States demand not only increased housing efforts but also comprehensive strategies addressing the underlying causes of chronic homelessness. Among the most prevalent factors is substance use disorder (SUD), which both contributes to and results from housing instability. Conventional abstinence-based treatment models often fail to address the root causes of substance use, particularly the chronic social isolation and rejection experienced by the unhoused. This thesis argues for the adoption of a neuroscience-informed model of recovery rooted in community reintegration and low-barrier housing with on-site support services.

The Neuroscience of Substance Use Disorders …

Braf V600e Mutation In Melanoma: A Comparative Meta-Narrative Review Of Detection Techniques And Their Diagnostic Efficacy, Sumaya Mahamed, Christopher Nava, Maria Julia Sanchez, Mayra Iliana Sandoval, Denise M. Juroske Short Ph.D., Mg(Ascp) Cm

Research Methods Poster Session 2025

No abstract provided.

Combining Internal Family Systems Therapy And Dance Movement Therapy To Treat Survivors Of Sexual Assault, Tierney O'Keefe

Scripps Senior Theses

The mammalian nervous system is primed to connect with loved ones, flee from danger, and shut down when overwhelmed. The nervous system frequently enters a state of chronic dysregulation after a traumatic event, such as a sexual assault. In order to properly heal from such trauma, treatment must address both the body and the mind. Internal family systems therapy and dance movement therapy provide two frameworks to address nervous system dysregulation and restore balance to the system as a whole. This study combines both therapies into a hybrid therapy treatment as an attempt to address the somatic nature of stored …

Gain-Of-Function Tp53 Mutations Induce Non-Canonical Nf-Κb Transcriptional Targets To Promote Tumor Development, Kelsey A. Yutan

Scripps Senior Theses

Background: Gain-of-function TP53 mutations have previously been shown to induce chromosomal instability (CIN) in cancer cells, triggering the cGAS-STING innate immune response and subsequently activating the non-canonical NF-κB (NC-NF-κB) signaling pathway. This signaling cascade promotes cancer cell metastasis and an immunosuppressive tumor microenvironment (TME), significantly impacting tumor development and progression. However, the precise downstream mechanisms by which the mutp53-CIN-cGAS-STING-NC-NF-κB signaling pathway facilitates tumor development and progression remain poorly understood. Here, our objective was to identify direct downstream targets of mutp53-CIN-cGAS-STING-induced NC-NF-κB signaling that potentially impact the TME to promote the development and progression of oral squamous cell carcinoma.

Methods …

Parental Monitoring, Latine Emerging Adult Marijuana And Alcohol Initiation, And The Relationship It Has With Marianismo And Machismo, Paola F. Ojeda

Scripps Senior Theses

The study aimed to expand the research on Latine adolescent alcohol and marijuana initiation in regard to their parent’s monitoring habits. The study investigated if parental monitoring affects the initiation of alcohol and marijuana for their adolescents. It also investigated if traditional gender roles in Latine households such as marianismo and machismo moderated the relationship. This study examined parental monitoring through asking participants about their parents monitoring habits and parents control habits during their adolescence. It also investigated Latine young adults’ substance use initiation. This study was conducted through a Qualtrics survey administered through Prolific with multiple subsections that pertain …

Co-Designing An International Nursing Course On Workplace Violence In Ethiopia, Sweden, And Tanzania: A Collective Autoethnography, Martin Salzmann-Erikson, Elisabet Eriksson, Tilahun Saol Tura, Tumbwene Mwansisya, Loveluck Mwasha, Malin Jordal

School of Nursing & Midwifery, East Africa

This study explores whether and how the co-creation of an international university course on workplace violence served as a site of transformative learning for us as nursing educators across Sweden, Ethiopia, and Tanzania. Using collaborative autoethnography, our team of six faculty members critically reflected on pedagogical assumptions, educator identities, and experiences of cross-cultural collaboration. The data comprised written reflections, meeting transcripts, and observational notes. Through this process, our pedagogical approaches and professional identities were reshaped, shifting from content deliverers to reflective co-learners within the cross-cultural partnership. Our analysis highlights the interplay of cultural negotiation, logistical frictions, and unspoken yet influential …

Exploring Physicians/Physician Assistants Perspectives On The Challenges And Communication Approaches When Communicating With People With Aphasia, Alexandra M. Rogers

SURF Posters 2025

Aphasia is an acquired language disorder that results from damage to the language areas of the brain, typically located within the left hemisphere. Individuals with aphasia often experience significant challenges while communicating with other individuals, including physicians and healthcare professionals. These barriers can ultimately lead to negative impacts on the quality of care, patient experiences, and overall health outcomes. The lack of consistent use of communication strategies as well as a general misunderstanding of aphasia by medical staff, further contributes to communication breakdowns. As a result, medical assessments can be misinterpreted, treatments may be delayed, and patients may feel less …

Contact Pathway Factors As Potential Modifiers Of Bleeding Related To Factor Xi Deficiency, Ivy R. Han, Leah Rosenfeldt, Courtney Young, Bal Krishan Phd, Rachel Cantrell Phd, Cassie Sprague, Mousa Kharnaf, William Abplanalp, Joseph Palumbo Md

Williams Honors College, Honors Research Projects

Factor XI (FXI) deficiency, also known as Hemophilia C, is characterized by mild to moderate bleeding symptoms. However, the factors that modify bleeding severity in FXI deficiency are not fully understood. In this study, we investigated whether components of the contact activation pathway can act as modifiers of bleeding in the context of FXI deficiency. Using a tail vein transection (TVT) model in rats, we assessed bleeding in four experimental groups: wild-type Sprague-Dawley rats, Prekallikrein knockout (PKK^-/-) rats, rats treated with a FXI-inhibiting antibody, and PKK-/- rats treated with the FXI antibody.

Under anesthesia, each rat underwent a …

An In-Depth Review Of Euthanasia-Related Practices, Arguments For/Against Them, And Proposed Solutions For Their Most Glaring Legal/Ethical Problems, Macon Plecha

Williams Honors College, Honors Research Projects

This paper’s goal is to cover the topic of euthanasia-related practices at great length. Terminology, history, and current programs around the world are discussed first, with the last point covering a wide geographical range: Colombia, Japan, Israel, and Africa, to name a few outside of the Western world standard. Arguments for and against euthanasia-related practices are explored. Within these arguments, several pressing legal and ethical issues arise, and the most severe of these are expanded on through the offering of potential solutions: how to handle stand-alone psychiatric cases, how to improve advanced directives and poor reporting rates, and how to …

Exploring Psychological Implications Of The Contemporary Lung Transplant, Isaac C. Machar

Williams Honors College, Honors Research Projects

Since its inception in 1963 at the University of Mississippi Medical Center, more than 50,000 lung transplant procedures have been performed. During its 50-year anniversary, 2023 saw just over 3,000 lung transplants performed in the United Sates. However, as this procedure continues to increase in execution each year, it is critical that the psychological implications of this procedure are explored. In this paper, I hope to develop an understanding of the psychological background of contemporary lung transplantation. Reviewing the lung and double lung transplant, the goal is to apply biopsychology principles to the field. Background information about transplant science is …

Research News, Publications, 2025, Volume 3, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of July 1 - September 30, 2025.

Research News, Publications, 2025, Volume 4, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of October 1 - December 31, 2025.

Research News, Grants, 2025, Volume 2, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during April - June 2025.

Research News, Grants, 2025, Volume 4, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during October - December 2025.

Medication In Early Adulthood And Long-Term Outcomes In Individuals With Adhd, Emma Deep

Williams Honors College, Honors Research Projects

The main question asked about attention deficit hyperactivity disorder is: What are the long-term consequences for adults who stay on ADHD medication after childhood? Answering that question includes looking into the medical facts surrounding an ADHD diagnosis, examining the adults and children with ADHD, the subtypes of ADHD, diagnosing ADHD, including the symptoms, and types of medications, along with the side effects. ADHD is one of the most common disorders in children and adults. Understanding ADHD, its diagnosis, and treatment options is crucial for individuals and caregivers navigating this condition. This paper examines the long-term effects of ADHD medication from …

Effects Of Energy Drinks On Crayfish Physiology, Melyna Sweeney

Williams Honors College, Honors Research Projects

Energy drinks have become the drink of choice among many college students due to the rush of energy it provides via the megadose of caffeine (Vercammen et al. 2019). Because of their newfound popularity, there is much research to be done about the effects on human physiology. Energy drinks are known to increase endurance in muscles of rat subjects (Imagawa et al. 2009) and stimulate enhanced “alertness” (Smit & Rogers, 2002). The purpose of this research was to uncover the potential effects that energy drinks have on metabolic rate and/or stress responses in crayfish (Procambarus clarkii), with the …

Astrocyte Specific Enhancers In The Cortex And Striatum Of Mice, Mikaela Kottelich

Williams Honors College, Honors Research Projects

Among glial cells, astrocytes have a prevalent influence on supporting neuronal function and overall brain health. Specifically targeting this cell type for disease treatment is an existing issue. Other cell types tend to express the desired treatment, which is not always wanted and can lead to unintended, negative consequences. Astrocytes contribute largely to maintaining the blood brain barrier, which is disrupted in Parkinson’s disease. Certain genes are thought to be the reason for this disruption, so if they can be specifically targeted in astrocytes with a specific enhancer, the disruption of the disease could be reversed. In our experiment, we …

Impact Of Tetrahydrocannabinol (Thc) On Daphnia Magna Heart Rate, Ashley Cosgrave

Williams Honors College, Honors Research Projects

Marijuana (Cannabis) is currently federally illegal within the United States and classified as a Schedule I drug. This leaves a large research gap on the impacts of Tetrahydrocannabinol (THC) use. Daphnia magna are frequently used as a model organism for the human heart and toxicology screenings due to their myogenic heart, similarities in physiological pathways, and sensitivity to toxins. As such, in order to bridge the research gap and uncover potential use of Daphnia magna as a model organism for humans in regard to impact on heart rate, we hypothesized that if Daphnia magna possess CB1 receptors or an equivalent …

Neurotensin Regulates Primate Ovulation Via Multiple Neurotensin Receptors, Andrew C. Pearson, Jessica S. Miller, Hannah J. Jensen, Ketan Shrestha, Thomas E. Curry Jr., Diane M. Duffy

Department of Biomedical and Translational Sciences Faculty Publications

Neurotensin (NTS), a small neuropeptide, was recently established as a key paracrine mediator of ovulation. NTS mRNA is highly expressed by granulosa cells in response to the luteinizing hormone (LH) surge, and multiple NTS receptors are expressed by cells of the ovulatory follicle. To identify the role of NTS receptors NTSR1 and SORT1 in ovulation in vivo, the dominant follicle of cynomolgus macaques (Macaca fascicularis) was injected with either vehicle control, the general NTS receptor antagonist SR142948, the NTSR1-selective antagonist SR48692, or the SORT1-selective antagonist AF38469. Human chorionic gonadotropin (hCG) was then administered to initiate ovulatory events. …

Enhancing Trust In Ai For Healthcare: A Quantative Evaluation Of Explainable Methods In Clinical Decision Support Systems, Abdul Aziz Noor

Masters

The integration of Artificial Intelligence (AI) into healthcare has revolutionized Clinical Decision Support Systems (CDSS) by enabling sophisticated predictive capabilities. However, the opaque nature of many machine learning models, commonly referred to as "black-box" systems, poses significant challenges to their adoption in critical clinical settings where transparency, interpretability, and trust are paramount. This thesis addresses these challenges by developing a rigorous, mathematically grounded framework to evaluate Explainable AI (XAI) methods and enhance their integration into CDSS.