Medicine and Health Sciences Commons^™

Implementation Of Robotics And Artificial Intelligence To Oncological Surgery, Ian Ngo

Nursing | Senior Theses

Background/ significance: Introduced in the late 20th century, robotic systems have enhanced surgeons’ capabilities by providing accurate and precise control of instruments. These systems helped minimize invasiveness in surgical procedures, providing greater precision, and gave flexibility to difficult-to-access areas of the body. Tools powered by AI help surgeons accurately identify and remove cancerous tissues, which can lead to better surgical outcomes and fewer complications. Purpose: The purpose of this study is to focus on evaluating how Robotic-Assisted Systems (RAS) and Artificial Intelligence (AI) impact surgical precision, patient recovery, and to address economic efficiencies. associated with integrating said systems into the …

The Impact Of Complementary Therapies On Postpartum Pain Relief Among Mothers Of Multiples, Jewel Thomas

Nursing | Senior Theses

The process of recovery after birth can be an arduous process for many women. Many patients experience discomfort that affects their quality of life. Especially for mothers who give birth to twins or triplets, there is additional need for support in this crucial time as they are more likely to develop postpartum complications. Current management for postpartum pain include pain control medications and heat/cold therapy. The purpose of this proposal is to examine if complementary therapies such as aromatherapy and music therapy decreases the postpartum pain levels in mothers of multiples. This paper proposes an experimental trial, in which a …

Impact Of Whole Foods Diet On Cognitive Functions In Children From Low-Income Families With Attention Deficit Hyperactivity Disorder (Adhd), Jasmine Le

Nursing | Senior Theses

Purpose

Current studies have examined dietary interventions for ADHD, emphasizing the value of good nutrition, the lack of nutritional foods in schools, and the difficulties low-income families have finding healthy options. Nutritious food has been shown to enhance cognitive abilities, yet many low-income households still lack access to it. This quantitative research will provide vital information for nurses and healthcare professionals on how they can assist these populations.

Methods

A quantitative randomized controlled design study will be conducted, with students separated into an experimental and control group. The objective will be to evaluate the effects of nursing nutrition education and …

Reducing Levels Of Compassion Fatigue Among Generation Z Hospital Nurses, Kailani Yee

Nursing | Senior Theses

Background: Compassion fatigue is a critical issue and one of the many difficulties encompassed within the nursing profession. It affects a large number of registered nurses who work in hospital settings and who are constantly exposed to the suffering of others. With more young nurses entering the workforce, it's imperative that there is a better understanding of how to properly address this issue among the youngest generation of nurses: Generation Z, or those born between 1997-2012.

Objective: This research proposal aims to explore the most effective strategies to decrease levels of compassion fatigue in Generation Z nurses working in hospital …

The Critical Role Of External Involvement In Supporting Adolescent Mothers Facing Postpartum Depression, Samantha Campopiano

Nursing | Senior Theses

Postpartum depression (PPD) is a significant mental health concern for adolescent mothers, especially those without a reliable support system. The current research demonstrates the importance of a support system, effective interventions, and prevention strategies for easier navigation of postpartum depression. Some effective interventions researched were therapy groups, personalized home visits, and using social media platforms to deliver therapy. This research proposal aims to examine the effectiveness of a nurse-led educational intervention for postpartum adolescent mothers without support. A quasi-experimental design will be used, with pre-and post-test assessments using the Edinburgh Postnatal Depression Scale (EPDS) to measure PPD symptoms in 100 …

Impact Of Non-Pharmacological Interventions On Immunization-Related Anxiety Among Pediatric Patients, Jessica Ho

Nursing | Senior Theses

Immunization-related anxiety can lead to vaccine hesitancy, which can be detrimental to public health by reducing herd immunity and increasing the spread of preventable diseases. This research proposal aims to investigate how nurses implementing non-pharmacological interventions can reduce immunization-related anxiety among pediatric patients. The literature critique focuses on examining the efficacy of various non-pharmacological interventions on reducing procedural pain, fear, and anxiety in pediatric patients. Research shows that those who received non-pharmacological interventions experienced decreased pain, fear, and anxiety levels. This proposal will use a randomized control trial design with a convenience sample of 200 pediatric patients from flu clinics …

The Impact Of A Educational Program On Depression And Anxiety For Low Socioeconomic Latina Postpartum Mothers, Lizbeth Valdez Duran

Nursing | Senior Theses

Postpartum depression (PPD) and anxiety are significant mental health challenges that affect many mothers, especially Latina women with low socioeconomic backgrounds. These mothers often face barriers to care, health literacy, and access to healthcare resources. The problem is compounded by a lack of culturally competent care, which can contribute to mistrust of healthcare providers and discourage Latina mothers from seeking help. The literature review articles highlight that health literacy plays a crucial role in managing mental health, with effective education potentially reducing negative outcomes by improving coping strategies and bringing awareness to symptoms that are associated with postpartum. This research …

Nursing Education On Sleep Health And Its Impact On Insulin Resistance In Adolescents, Salamasina Tufa

Nursing | Senior Theses

Modern-day adolescents are increasingly at risk for poor sleep quality due to rapid physical and physiological changes and stressors from technology and social media. Recent research suggests poor sleep affects endocrine function and contributes to insulin resistance (IR), a precursor to Type II Diabetes Mellitus (T2DM). This proposed quasi-experimental study will examine if a nurse-led sleep education program can improve sleep quality and decrease the incidence of IR in adolescents with poor sleep. A total of 100 participants aged 12-18 across Berkley, California who score ≥ 5 on the Pittsburgh Sleep Quality Index (PSQI) will be randomly assigned to either …

Preparing Nurses For Medical-Assistance In Dying: The Role Of Comprehensive Education And Training, Keira O'Reilly

Nursing | Senior Theses

Medical-assistance in dying (MAID) is a process in which a consenting patient self-administers lethal medications with the intent of ending their life. This process is marked with ethical, emotional, and spiritual complexities. Nurses play a key role in MAID, through providing care as well as being a patient advocate. Specifically, intensive care unit (ICU) nurses often provide care to critical or terminally ill patients. However, according to the research, little formal training or education about MAID has been put into place for ICU nurses. To investigate, primary research articles regarding healthcare professionals’ experiences with MAID, educational gaps, and current training …

Delayed And Misdiagnosed Endometriosis, Teresa Doyle

Nursing | Senior Theses

Aim: This research investigates whether targeted education can improve the early diagnosis of endometriosis, a chronic condition affecting around 10% of women of reproductive age. Unfortunately, endometriosis is often misdiagnosed, delaying treatment, prolonging discomfort, and lowering quality of life. Healthcare practitioners' knowledge gap is addressed by this study, which examines whether organized training promotes awareness and diagnostic accuracy. This research proposal evaluates an educational intervention developed to improve gynecological experts' knowledge and diagnostic skills. The main research issue is whether the intervention reduces misdiagnosis and improves patient outcomes. A quasi-experimental design will examine participants' knowledge and diagnosis accuracy before and …

Understanding Avoidant Restrictive Food Intake Disorder (Arfid) In Autistic Children Through Parent’S Lens, Lisette Oviedo

Nursing | Senior Theses

This research reviews and proposes a study to assess parents' knowledge about their children with a dual diagnosis of autism and Avoidant-Restrictive Food Intake Disorder (ARFID) with the intent to develop future care strategies that are both person-centered and family-centered.

Shadows Of Self Doubt: Exploring The Dual Threat Of Impostor Syndrome On New Nurses And Quality Care, Siona Patel

Nursing | Senior Theses

Every nursing student goes through a transition period after nursing school where they step into the role of a new graduate nurse, and adapt to the demands of the clinical setting. Their acquired knowledge and skills taught to them are now applied to high stake situations of the real world. This critical time period is often paired with a mental phenomenon known as imposter syndrome in which competent people feel doubt or fraudulently of their skill set which can affect patient care and cause burnout. This thesis explores the connection between imposter syndrome and burnout and their impact on patient …

Nursing Knowledge Regarding Pap Smears For Transgender Men, Caytlin Capulong

Nursing | Senior Theses

Cervical cancer screening (CCS) is a crucial test used for preventative measures against cervical cancer, yet transgender men (TM) experience significantly lower screening rates in comparison to cisgender women due to pain, anxiety, and systemic healthcare barriers. A major factor for deterrence is pain during speculum insertion, often because of vaginal atrophy related to testosterone usage. Other factors include fear of discrimination, mistreatment, and lack of provider awareness, particularly among nurses who play a pivotal role in patient preparation and care. This research aims to assess the extent of nurses’ knowledge regarding Pap smears for female-to-male (FTM) patients through a …

The Impact Of Workplace Stressors On Anxiety Levels And Mental Health Among Pediatric Intensive Care Nurses, Kelsey Ang

Nursing | Senior Theses

Background: Pediatric Intensive Care Unit (PICU) nurses work in a high-stress environment where they are exposed daily to traumatic situations. The demanding emotional and physical challenges contribute to significant psychological burdens, including increased stress and anxiety. Purpose: The current paper proposes a research design to examine the outcomes of stress, anxiety levels, and mental well-being on PICU nurses when workplace support and structured debriefing sessions take place following a traumatic event. Methods: Participants will be recruited from PICU hospitals in Northern California. Participation will be voluntary, and informed consent will be obtained prior to the study. The selection criteria will …

The Impact Of Maternal Mental Health On Child Development, Jessica White

Nursing | Senior Theses

Purpose

This research investigates the impact of early maternal mental health interventions on child development, focusing on cognitive, emotional, and social behaviors. The study aims to evaluate whether children whose mothers receive mental health interventions, such as support for depression and anxiety, show improved developmental outcomes compared to children whose mothers do not receive such interventions.

Methods

The study will include 100 mother-child pairs, recruited from clinics in Northern California. Child developmental outcomes will be assessed using standardized tools: Wechsler Intelligence Scale for Children (WISC-V), Strengths and Difficulties Questionnaire (SDQ), and Social Skills Improvement System Rating Scales (SSIS-RS). Follow-ups will …

The Impact Of Sleep Deprivation On Maternal Decision-Making And Risk-Taking Behavior, Stephanie Marea B. Martinez

Nursing | Senior Theses

Purpose

The purpose of this research proposal aims to explore the impact of sleep education in new mothers and their ability to manage sleep deprivation with interventions during the postpartum period.

Methods

This research proposal includes various methods to evaluate the effectiveness of sleep education and mental health screenings in new mothers. The baseline data for sleep quality, postpartum depression, and the new adaptation to motherhood will be collected using the Edinburgh Postnatal Depression Scale, actigraphy to monitor sleep patterns, and a conduction of cognitive functioning with the Mini-Mental State Examination. After interventions are put into place, follow up data …

Targeting Rna Polymerase I In Ewing Sarcoma Treatment, Alexis Bruce, Gavin Anchondo, Rebekah Carter, Sergio Guerrero Pacheco, Hema Sri Kambala, Elizabeth Cortez, Kyra Parker, Le Su

Research, Publications & Creative Work

Ewing sarcoma (ES) is a high-grade bone and soft tissue tumor in adolescents and young adults. Cytotoxic chemotherapy does not improve prognosis, especially for advanced ES patients who have a 5-year survival of 30% or less [1, 2]. Molecular targeted therapy emerges as a promising strategy to battle ES, given its unique driver mutations resulting from the fusion of the EWS and one of the ETS genes, but the feasibility of directly blocking EWS-ETS function has not yet been established [3]. To search for new therapeutic targets, we began with an analysis of the Cancer Dependency Map (DepMap) datasets that …

Pediatric Cervical Spine Clearance: A 10-Year Evaluation Of X-Ray In Evaluable Patients At A Level 1 Pediatric Trauma Center, William Starr, Stephanie Iantorno, Jing Wang, Richard Eldredge, Rajiv Iyer, Karch Smith, Natalya Mcnamara, Kezlyn Larsen, Stephen Fenton, Robert Swendiman, Katie Russell

2020-Current year OA Pubs

OBJECTIVES: Cervical spine (c-spine) X-ray (XR) remains an important tool for pediatric trauma patients. XR is a low radiation alternative to multidetector CT (MDCT). Our primary aims were to analyze the sensitivity of a negative c-spine XR and to analyze what factors lead to additional imaging after a negative c-spine XR.

METHODS: A retrospective cohort study was conducted at a level 1 pediatric trauma center from 2012 to 2021. We compared the group with negative c-spine XR and no additional imaging to the group with negative c-spine XR followed by additional c-spine MDCT and/or MRI.

RESULTS: There were 2,081 negative …

High-Dose Beta-Alanine Supplementation For Two Weeks Did Not Enhance Intermittent Endurance Or Sprint Performance In Trained Futsal Players, Hossein Miraftabi, Erfan Berjisian, Marzieh Nouri Dizicheh, Alireza Naderi, Masoud Bodaghi, Majid Koozehchian, Fatemeh Shabkhiz, Alvaro Lopez-Samanes

Research, Publications & Creative Work

Background: This study aimed to investigate the effects of a high-dose beta-alanine (BA) supplementation on physical performance, blood lactate concentration, and ratings of perceived exertion (RPE) in trained futsal players. Methods: Sixteen trained futsal players participated in a randomized, parallel, double- blind experiment, completing a two-week supplementation period with either 12 g/day of BA (n = 8; age: 19 ± 2 years; height: 1.78 ± 0.03 m; body mass: 68.5 ± 5.4 kg) or a placebo (PLA) (n = 8; age: 18 ± 1 years; height: 1.74 ± 0.08 m; body mass: 65.6 ± 6.4 kg). Athletes completed the futsal …

Trends In U.S. Health Care Bankruptcy: A 10-Year Retrospective, Amy Yarbrough Landry, Philip Cendoma, Kristine R. Hearld, J'Aime C. Jennings, Robert J. Landry Iii

Research, Publications & Creative Work

Background: In recent years, the United States (U.S.) healthcare system has faced financial challenges resulting from changing reimbursement models, fluctuations in sources of investment, and a global pandemic. These factors have resulted in an influx of bankruptcy filings among healthcare organizations. This study explores the number of healthcare organizations filing for bankruptcy as means to reorganize (Chapter 11) or liquidate assets (Chapter 7), and examines whether organizational size, defined by assets and liabilities, influences the success of reorganization. The research on bankruptcy among healthcare organizations has been limited to larger businesses including hospitals and nursing homes. This study investigates all …

Dose–Response Effects Of Short-Term Rhodiola Rosea (Golden Root Extract) Supplementation On Anaerobic Exercise Performance And Cognitive Function In Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, And Placebo-Controlled Study, Majid Koozehchian, Andrew T. Newton, Gina Mabrey, Faith M. Bonness, Rafaela Rafajlovska, Alireza Naderi

Research, Publications & Creative Work

Background: Rhodiola rosea (RR) is marketed as an adaptogen; however, evidence for acute/short-term effects—and especially dose–response effects—in trained adults across performance and cognition is limited.

Objective: Test whether RR improves resistance performance (strength, power) and executive function in resistance-trained adults using a randomized crossover with placebo and a capsule-free baseline.

Methods: In a randomized, double-blind, crossover trial with four conditions—no-capsule control (CON), placebo (PL), low-dose RR (LDRR), and high-dose RR (HDRR). Twenty-seven resistance-trained adults completed the conditions. Day-7 testing included bench press (BP) and leg press (LP) 1-repetition maximum (1RM); a third set to failure at 60% 1RM with set-3 …

Formulation Development Of Dual-Compartment Topical Inserts Combining Tenofovir Alafenamide And Elvitegravir For Flexible On-Demand Hiv Prevention, Vivek Agrahari, M. Melissa Peet, Neelima Chandra, Prakash Ramalingam, Pardeep K. Gupta, Sriramakamal Jonnalagadda, Onkar N. Singh, Timothy J. Mccormick, Gustavo F. Doncel, Meredith R. Clark

Department of Obstetrics & Gynecology Faculty Publications

Pre-exposure prophylaxis (PrEP) has emerged as a prominent approach for the prevention of HIV infections. While the latest advances have resulted in effective oral and injectable product options, there are still gaps in on-demand, event-driven, topical products for HIV prevention that are safe and effective. Here we describe the formulation development of a dual-compartment topical insert containing tenofovir alafenamide fumarate (TAF) and elvitegravir (EVG) that may be administered when needed, vaginally or rectally, pre- or post-coitus, for flexible HIV prophylaxis. Specifically, we describe the lab-scale formulation development, preclinical mucosal safety and pharmacokinetics (PK) testing in rabbits, long-term stability, and scale-up …

In Danger: Hiv Vaccine Research And Development In Europe, Roger Tatoud, Yves Lévy, Roger Le Grand, Jose Alcami, Giorgio Barbareschi, Christian Brander, Andrea Cara, Behazine Combadière, François Dabis, Sarah Fidler, Tomáš Hanke, Carolina Herrera, Gunilla B. Karlsson Hedestam, Hester Kuipers, Sheena Mccormack, Christiane Moog, Giuseppe Pantaleo, Laura Richert, Rogier W. Sanders, Robin Shattock, Hendrik Streeck, Rodolphe Thiebaut, Alexandra Trkola, Klaus Üeberla, Marit J. Van Gills, Ralf Wagner, Winfried Weissenhorn, Yazdan Yazdanpanah, Gabriella Scarlatti, Jean Daniel Lelièvre

Department of Obstetrics & Gynecology Faculty Publications

Highly effective antiretroviral-based HIV prevention plays an important role in ending the global HIV/AIDS epidemic. However, the sustainable control of the epidemic is hampered by unequal access to prevention options, including HIV testing, alongside with drug resistance and ongoing barriers to accessing sustainable HIV treatment. Therefore, an HIV vaccine, combined with effective prevention and treatment, remains an absolute necessity to control the epidemic. Yet, the recent discontinuation of four major vaccine efficacy studies is raising concerns about the future of HIV vaccine research and development globally, and particularly in the European region where funding for vaccine research and development has …

Association Between The Social Vulnerability Index And Adverse Pregnancy Outcomes, Tetsuya Kawakita, Misa Hayasaka, Lindsay Robbins, Juliana Martins, George Saade

Department of Obstetrics & Gynecology Faculty Publications

Objective: To assess the association between the Social Vulnerability Index (SVI) and racial disparities in pregnancy outcomes across U.S. counties and to quantify these racial disparities.

Methods: This was a cross-sectional study using restricted Centers for Disease Control and Prevention data sets, including natality data sets, fetal death data sets, and all-cause mortality data sets from 2016 to 2021. We limited analyses to Black or White individuals aged 15-44 years from 3,114 U.S. counties. Participants were categorized into quartiles based on county-level SVI. The primary outcome was maternal mortality rate while pregnant or within 42 days of the end of …

Microbial Remodeling Of Gut Tryptophan Metabolism And Indole-3-Lactate Production Regulate Epithelial Barrier Repair And Viral Suppression In Human And Simian Immunodeficiency Virus Infections, Clarissa Santos Rocha, Katie L. Alexander, Carolina Herrera, Mariana G. Weber, Irina Grishina, Lauren A. Hirao, Dylan J. Kramer, Juan Arredondo, Abigail Mende, Katti R. Crakes, Anne N. Fenton, Maria L. Marco, David A. Mills, John C. Kappes, Lesley E. Smythies, Paul Ziprin, Sumathi Sankaran-Walters, Phillip D. Smith, Satya Dandekar

Department of Obstetrics & Gynecology Faculty Publications

Gut inflammatory diseases cause microbial dysbiosis. Human immunodeficiency virus-1 (HIV) infection disrupts intestinal integrity, subverts repair/renewal pathways, impairs mucosal immunity and propels microbial dysbiosis. However, microbial metabolic mechanisms driving repair mechanisms in virally inflamed gut are not well understood. We investigated the capability and mechanisms of gut microbes to restore epithelial barriers and mucosal immunity in virally inflamed gut by using a multipronged approach: an in vivo simian immunodeficiency virus (SIV)-infected nonhuman primate model of HIV/AIDS, ex vivo HIV-exposed human colorectal explants and primary human intestinal epithelial cells. SIV infection reprogrammed tryptophan (TRP) metabolism, increasing kynurenine catabolite levels that are …

Exposure To Phthalates And Replacements During Pregnancy In Association With Gestational Blood Pressure And Hypertensive Disorders Of Pregnancy, Erin E. Mcnell, Danielle R. Stevens, Barrett M. Welch, Emma M. Rosenthal, Suzanne Fenton, Antonia M. Calafat, Julianne Cook Botelho, Elena Sinkovskaya, Ann Przybylska, George Saade, Alfred Abuhamad, Kelly K. Ferguson

Department of Obstetrics & Gynecology Faculty Publications

Exposure to endocrine-disrupting chemicals such as phthalates may increase risk of hypertensive disorders of pregnancy (HDP). Prior studies lack investigation of chemical mixtures, phthalate replacements, or key periods of susceptibility including early pregnancy. In the present study, we used a longitudinal approach to evaluate gestational exposure to phthalates and replacements, as both single-pollutants and mixtures, in association with blood pressure and diagnosis of preeclampsia or any HDP. The Human Placenta and Phthalates prospective pregnancy cohort includes 291 participants recruited from two U.S. clinics. Urinary metabolites of ten phthalates and replacements were quantified at up to 8 time points per individual …

Association Of Prenatal Exposure To Phthalates And Phenols With Adverse Pregnancy Outcomes, Misa Hayasaka, Diana Aboukhater, George Saade, Tetsuya Kawakita

Department of Obstetrics & Gynecology Faculty Publications

OBJECTIVE:

To evaluate the association between prenatal exposures to phthalates and phenols and adverse pregnancy outcomes, including preterm birth (PTB), small-for-gestational-age (SGA) birth weight, and gestational diabetes mellitus (GDM).

METHODS:

This study analyzed data from the Environmental Influences on Child Health Outcomes consortium, which harmonized longitudinal data on more than 30,000 pregnancies and 57,000 children from 69 cohorts across the United States and Puerto Rico. Pregnancy outcomes included PTB, SGA, and GDM, identified from medical records or self-reports. Generalized estimating equations models with Poisson distribution and robust variance were used to estimate relative risks (RRs) and 95% CIs per interquartile …

Association Of Maternity Care Deserts With Maternal And Pregnancy-Related Mortality, Rula Atwani, Lindsay Robbins, George Saade

Department of Obstetrics & Gynecology Faculty Publications

OBJECTIVE:

To evaluate the association between the level of maternity care access and maternal and pregnancy-related mortality.

METHODS:

This was a cross-sectional analysis of county-level data in the United States from January 2018 to December 2021. Using the level of maternity care access, we categorized counties into desert, low access, moderate access, and full access. The primary outcome of interest was maternal mortality rate per 100,000 live births. A secondary outcome was pregnancy-related mortality rate per 100,000 live births. Absolute risk differences and adjusted incidence rate ratios were calculated for maternal mortality and pregnancy-related mortality with multivariable negative binomial mixed-effects …

Methodological And Clinical Concerns In The Study On Postpartum Hypertension Management, Takaki Tanamoto, Kyosuke Kamijo, Yusuke Tsutsumi, Tetsuya Kawakita

Department of Obstetrics & Gynecology Faculty Publications

[Introduction] We read with interest the recent study by Rosenfeld et al.¹ However, we have several clinical and methodological concerns about this study.¹

First, this study's propensity score matching (PSM) lacked key clinical confounders, including perinatal risk factors and the highest systolic/diastolic blood pressures. Smoking, alcohol use, and multifetal gestation, which influence blood pressure during pregnancy,²,³ potentially affect both primary and secondary outcomes. Additionally, the authors did not report standardized mean differences before and after PSM, which are essential for assessing balance.⁴

Disparities In Cardiovascular Disease Outcomes And Economic Burdens Among Minorities In Southeastern Virginia, Ismail El Moudden, Asra Amidi, Reem Sharaf Alddin, Michael Bittner, Qi Zhang

Department of Obstetrics & Gynecology Faculty Publications

Background

Cardiovascular diseases are the leading cause of mortality in the United States, presenting significant public health challenges and financial burdens, particularly in Southeastern Virginia, where African American and Hispanic (AA&H) populations are disproportionately affected.

Methods

This retrospective observational study analyzed data from 30,855 hospital discharges of AA&H patients across Southeastern Virginia from 2016 to 2020, focusing on individuals aged 18 to 85 with cardiovascular diseases. Utilizing the Virginia Health Information database, we examined demographic information, clinical data, and healthcare utilization patterns through hypothesis tests and regression models to explore associations between these variables and the economic impacts of cardiovascular …