Medicine and Health Sciences Commons^™

Predicting Lung Cancer Severity Using Machine Learning Algorithms: Enhanced By Statistical Analysis, Esin Bilgin

Theses, Dissertations and Culminating Projects

Cancer is a serious and severe cause seen in every region of the world and severely affects the quality of life and life span. Among the various types of cancer, lung cancer is one of the most critical, having a fatal impact on life. While medical imaging techniques, laboratory results, and biomarkers play a significant role in diagnosis and prognosis, clinical studies are also crucial in monitoring the progression of cancer and identifying diagnostic and prognostic factors. The findings demonstrate satisfactory accuracy, and the analysis incorporates statistical data with machine learning techniques. These findings play a pivotal role in supporting …

Quantitative Preventive Approaches To Diabetes: Mathematical Modeling And Analysis, Rushi P. Bhatt

Theses, Dissertations and Culminating Projects

The rising prevalence of diabetes presents a pressing global health concern, necessitating effective control strategies. This study aims to construct a mathematical model to analyze the influence of diverse factors on blood sugar levels, with a focus on identifying optimal methods for maintaining healthy glucose levels. Employing ordinary differential equations (ODE), the model investigates variables including leptin resistance, fat mass, glucose, insulin resistance, beta cell mass, daily physical activity, and dietary intake. Utilizing parameter estimates from existing literature, the model’s framework is established, and simulation results elucidate the intricate interplay between lifestyle choices and blood glucose dynamics. Furthermore, the model …

Effect Of Dexmedetomidine Versus Magnesium Sulfate On Intraocular Pressure In Glaucoma Surgery: A Randomized Controlled Trial, Nourhan E. Elhadidi, Nevert A. Abdelghaffar, Nabil A. Mageed, Amany Tarbay

Mansoura Medical Journal

Background : Lowering the intraocular pressure (IOP) is regarded as a primary and initial treatment option for glaucoma. Dexmedetomidine and Magnesium sulfate are known to have intraocular pressure-lowering effects which improve visual fields in patients with primary open angle glaucoma and attenuate intraocular pressure spikes induced by tracheal intubation. Aim: To evaluate and compare the safety and efficacy of using Dexmedetomidine versus Magnesium Sulfate on intraocular pressure and the incidence of postoperative hyphema. Methods : This study included 100 patients both male and female with American Society of Anesthesiologists (ASA) physical status class ɪ and ɪɪ scheduled to undergo elective …

D-Dimer As A Bio-Marker For Assessment Of Disease Activity In Rheumatoid Arthritis Patients, Ahmed Othman, Amir A. Youssef, Y. Tera, Yasmin Adel

Mansoura Medical Journal

Background Rheumatoid arthritis (RA) is considered the most common inflammatory joint disorder. It can lead to early morbidity, mortality and increased incidence of functional disability. Achieving rapid remission in early disease appears to be a beneficial strategy in preventing work disability in RA patients. The lack of specificity of commonly used inflammatory markers prompted the investigation of novel ones for estimating disease activity in RA. D-dimer has been one of these new markers, as RA is known to induce a hypercoagulable state. Aim This study aimed to investigate the possibility of utilizing D-dimer as a potential marker for assessing RA …

Examining The Relationship Between Cognitive Auditory Processing And Sex Hormones, Trey A. Cline

Theses and Dissertations--Gerontology

Estrogen and progesterone have demonstrated modulatory effects on central auditory nervous system (CANS) function. Post-menopausal females often present to audiology clinics with complaints of difficulty hearing in background noise. However, these individuals often have normal peripheral hearing sensitivity on standard audiometry. Previous studies using the auditory brainstem response (ABR) in post-menopausal females demonstrated longer response latencies compared to their premenopausal counterparts, suggesting that sound does not transmit through the CANS as efficiently. However, to date, the available literature focused on sex hormones and the CANS relies mainly on objective measures, predominantly the ABR. The ABR reflects physiologic function through the …

A New Risk Assessment Scale For Pressure Injuries In The Icu: The M.D.R. Scale, Ann Murdock, Andrea Daily, Deb Reilly, Shih-Ting Chiu

Articles, Abstracts, and Reports

No abstract provided.

Inpatient Utilization Among Medicaid Members With Substance Use And Serious Mental Illness In Oregon, Megan Holtorf

Articles, Abstracts, and Reports

No abstract provided.

Addressing Housing As A Health-Related Social Need: Insights From A Medicaid Housing Pilot In Oregon, Megan Holtorf, Benjamin Gronowski

Articles, Abstracts, and Reports

No abstract provided.

Perceptions Of The Health Care System As Mediators In The Association Between Experiences Of Discrimination, Communication From Providers, And Gaps In Mammography, Hannah Cohen-Cline

Articles, Abstracts, and Reports

No abstract provided.

Experiences And Impacts Of A Hospital-Based, Spanish-Language Teaching Kitchen And Garden On Staff And Participants, Sarah E Roth, Benjamin Gronowski, Heidi Davis

Articles, Abstracts, and Reports

No abstract provided.

Oregon Doula Workforce Analysis, Aisha K Gilmore, Apoorva Somayazulu, Lindsay Dickey, Rosemelty Jimenez Medal

Articles, Abstracts, and Reports

No abstract provided.

Early Palliative Care In Heart Failure, Meadow Stempek, Beverly Balfe, Jennifer Tantarelli

Articles, Abstracts, and Reports

No abstract provided.

In Vitro Evaluation Of Retention Of Double-Crown Prostheses Connecting Natural Teeth And Implants. A Comparative Analysis Of Zirconia, Pekk, And Cobalt Chromium Materials For Primary And Secondary Crowns, Sarah Zaman Sahib Awad, Khloud Ezzat Mourad, Ahmed Sameh Abdelaziz Ismail, Aisha Zakaria Hashem Mostafa

Mansoura Journal of Dentistry

Purpose Objective: To assess and compare the retention performance of different material combinations—Zirconia, PEKK, and Cobalt-Chromium—over time using insertionremoval tests simulating one year of use. Materials and Methods: Nine mandibular polyurethane models with two canines and two dummy implants (first molar area) were used. Three groups of double-crown prostheses were fabricated, differing in materials used for both primary and secondary crowns: Zirconia, PEKK, and Cobalt-Chromium. All crowns were CAD/CAM-designed. Retention was tested using a Universal Testing Machine, with each overdenture subjected to 1,440 insertionremoval cycles to simulate one year. Final retention forces were measured and analyzed using SPSS v23, with …

Mandibular Chondrosarcoma: A Rare Case Report, Moataz Elhefny, Islam Hamada, Ahmed Khalil

Mansoura Journal of Dentistry

Purpose: Chondrosarcoma is a malignant tumor of cartilaginous tissue. It is more apparent in the axial skeletal bone but rare in the head and neck region. The biopsy is the definite way to diagnose Chondrosarcoma and surgical dissection is the direct way of management. Case description: A 76 years old male patient diagnosed with Chondrosarcoma in the mandible at the the premolar region after a history of a non-specific sclerosing osteomyeiltis at the same region 7 months ago. It was a low-grade form with good prognosis. Conclusions: Chondrosarcoma is malignant neoplasm of cartilaginous tissue. It is rare in the oral …

Bolton’S Tooth Width Discrepancies Among Orthodontic Patients In A Tanzanian Population, Ferdinand Mabula Machibya, Eladius Laswai Daniel, Matilda Mtaya Mlangwa

Mansoura Journal of Dentistry

Aim: The aim of the current study was to assess the prevalence of intermaxillary teeth width discrepancy among orthodontic patients in a Tanzanian population. Methods: A cross sectional retrospective study was carried involving 204 orthodontic casts. Data collection involved mesio-distal teeth width measurement of all teeth anterior to second molars using a digital Vernier Caliper. Intermaxillary teeth width ratios between lower and upper teeth was then determined according to Bolton’s formula. Independent t test was used to assess whether anterior and overall intermaxillary teeth width ratios vary between males and females. The prevalence of Bolton’s teeth width discrepancies were determined …

Adaptation Of Cantilever Endocrown Fixed Partial Denture: Effect Of Design And Material Type, Fatimah M. Abu Alrub, Nesma M. El-Gohary, Walid Al-Zordk

Mansoura Journal of Dentistry

Objective: The purpose of this in-vitro study was to evaluate the effect of using different material type and different preparation design on marginal and internal adaptation of cantilever endocrown fixed partial denture. Materials and Methods: Fifty-six mandibular first molars were randomly collected and divided into two main groups (n=28) according to preparation design Group B: butt joint and Group C: 1 mm chamfer finish line. Each group will be subdivide into four subgroups (n=7) according to the material type used, sub-group 1: zirconia, sub-group 2: zirconia reinforced lithium silicate (ZLS), sub-group 3: fiber reinforced composite (FRC) and sub-group 4: polyether …

Fracture Resistance Of Monolithic Zirconia Crowns After Endodontically Access Preparation On Premolars Teeth, Abeer Tambah, Nesma Mohamed Magdy El-Gohary, Walid Abd El-Ghafar Al-Zordk

Mansoura Journal of Dentistry

Objective The present study aimed to evaluate the fracture resistance of endodontically treated premolars with monolithic zirconia crowns following standardized endodontic access cavity preparation and restoration with either composite or ceramic inlays. Materials and Methods Twenty extracted human premolars were selected and endodontically treated after creating standardized ovoid access cavities through the zirconia crowns using a highspeed diamond bur under water cooling. Specimens were randomly divided into two groups (n=10 per group): Group 1 restored with bulk-fill composite resin and Group 2 restored with CAD/CAM-fabricated ceramic inlays. Following thermocycling (10,000 cycles, 5–55 °C) and cyclic mechanical loading (240,000 cycles, 50 …

Effect Of Different Implant Designs On Primary Stability In Different Substrates, Mohamed Adel Ebrahim, Ahmad Mostafa Hussein, Mohamed Abdelmonem Tawfik, Elsayed Gad Eid

Mansoura Journal of Dentistry

Objective To clarify whether implant macrodesign has any influence on primary stability. Implant primary stability was evaluated in different substrates (fresh cow ribs and polyurethane artificial bone blocks) using several methods. Materials and Methods A total of 36 titanium dental implants (3.5 mm × 10 mm) and then divided into 3 groups (n=12): implants have trapezoidal thread design, implants have buttress thread design and implants have reverse buttress thread design were inserted in two different substrates (six fresh cow ribs and eighteen polyurethane casts). Immediately after insertion of dental implant, the implant stability was measured using three different methods (insertion …

Fracture Resistance Of Different Lithium Disilicate Restorations After Endodontic Access Cavity Preparation: Effect Of Repair Method, Hebah Agamal Abdulghafor, Essam A. Khedr, Nesma M. Elgohary, Walid A. Al-Zordk

Mansoura Journal of Dentistry

Objective: To evaluate the effect of different repair methods on the fracture resistance of lithium disilicate restorations after endodontic access cavity preparation. Materials and Methods: One hundred sixty sound human mandibular first molars were prepared and restored with four types of lithium disilicate–based crowns: IPS e.max CAD, GC Initial LiSi Block, Straumann n!ce, and CEREC Tessera (n = 40 each). Standardized endodontic access cavities were prepared in all specimens, then repaired using one of four techniques: (1) inlay restoration with Monobond Etch&Prime, (2) inlay restoration with IPS Ceramic Etching Gel + Monobond Plus, (3) direct composite with IPS Ceramic Etching …

Editing Approaches To Treat Alpha-1 Antitrypsin Deficiency, Derek M. Erion, Leah Y. Liu, Christopher R. Brown, Stephen I. Rennard, Humam Farah

Journal Articles: Pulmonary & Critical Care Med

TOPIC IMPORTANCE: Alpha-1 antitrypsin (AAT) deficiency is a genetic disorder most commonly due to a single G to A point mutation (E342K), leading to debilitating lung and/or liver disorders and is associated with increased mortality. The E342K point mutation causes a conformational change of the AAT protein resulting in its retention in liver hepatocytes. This reduces AAT secretion into the serum resulting in higher protease activities due to the lack of inhibition from AAT, causing damage to healthy lung tissue. The current standard of care for lung manifestations involves weekly IV augmentation therapy and is considered suboptimal for these patients. …

High-Resolution Geospatial Database: National Criteria-Air-Pollutant Concentrations In The Contiguous U.S., 2016–2020, Tianjun Lu, Sun-Young Kim, Julian D. Marshall

Epidemiology and Environmental Health Faculty Publications

Concentration estimates for ambient air pollution are used widely in fields such as environmental epidemiology, health impact assessment, urban planning, environmental equity and sustainability. This study builds on previous efforts by developing an updated high-resolution geospatial database of population-weighted annual-average concentrations for six criteria air pollutants (PM_2.5, PM₁₀, CO, NO₂, SO₂, O₃) across the contiguous U.S. during a five-year period (2016–2020). We developed Land Use Regression (LUR) models within a partial-least-squares–universal kriging framework by incorporating several land use, geospatial and satellite–based predictor variables. The LUR models were validated using conventional …

Guidelines For The Use Of Artificial Intelligence In Manuscript Preparation And Review: Aenj’S Current Perspective On Artificial Intelligence, K. Sue Hoyt, Donna Agan

School of Nursing and Health Science: Faculty Scholarship

No abstract provided.

From Classroom To Practice: Boosting Enp Proficiency With Online Pocus Training, Andrew Walsh, Pedro A. Colio, Sukhdeep Singh

School of Nursing and Health Science: Faculty Scholarship

No abstract provided.

Social Determinants Of Health And Health Confidence: A Cross-Sectional Study, Laura Truman, Patricia Calero, Caroline Etland, Razel Bacuetes Milo, Cynthia D. Connelly

School of Nursing and Health Science: Faculty Scholarship

No abstract provided.

Between-Visit Asthma Symptom Monitoring With A Scalable Digital Intervention: A Randomized Clinical Trial, Robert S. Rudin, Savanna Plombon, Jorge Sulca Flores, Jessica L. Sousa, Jorge Rodriguez, Dinah Foer, Stuart Lipsitz, Maria O. Edelen, David Bates, Adriana Arcia, Anuj K. Dalal

School of Nursing and Health Science: Faculty Scholarship

No abstract provided.

A Systematic Review Of The Non-English Versions Of The Perceived Stress Scale (Pss)-10 Psychometric Analysis, Razel Bacuetes Milo, Arlin Ramira, Sandra Peppard, Maria Luisa B. Ramira, Roxane Brown, Kathleen Soon, Maria Fontimayor, Jaden B. Milo, Patricia Calero

School of Nursing and Health Science: Faculty Scholarship

No abstract provided.

Translated Versions Of The English Satisfaction With Life Scale (Swls) Among Adult Participants: A Systematic Review, Razel Bacuetes Milo, Nicole Martinez, Theresa Asmus, Jennie Lee, Kathleen Soon, Jaden Milo, Patricia Calero

School of Nursing and Health Science: Faculty Scholarship

No abstract provided.

Exploring The Impact Of Pain Management Agreements On Physician-Patient Relationship: A Qualitative Analysis From The Patient’S Perspective In Opioid Analgesic Treatment, Shriya Doranala

Honors Undergraduate Theses

Pain management agreements are increasingly used in the treatment of chronic pain with opioid analgesics. These agreements aim to reduce misuse of opioids by providing patients clear regulations and requirements to follow during treatment. This study seeks to assess the effect of pain management agreement for opioid treatment on the patient-physician relationship from the perspective of patients with a pain management agreement in the past two years. We recruited participants for the semi-structured interview through online media groups dedicated to patients with chronic pain that is treated with opioids. A cohort of eight individuals recruited from September 2023 to January …

Evaluating Impact Of Stress First Aid Programs In A Primary Care Setting, Ryan Marler

DNP Projects

Background: Prolonged stress in healthcare workers (HCWs) can lead to burnout and absenteeism. High stress also negatively impacts work productivity and healthcare quality. The Stress First Aid (SFA) program aims to improve recovery from stress among HCWs. Chronic stress is evident in primary care clinics, where absenteeism and burnout symptoms have increased.

Purpose: This project aimed to evaluate the SFA program's effectiveness in reducing burnout and absenteeism and improving healthcare workers (HCW) knowledge of stress and available resources at University of Kentucky Healthcare (UKHC).

Methods: A quasi-experimental quality improvement project included pre- and post-education surveys, an SFA education session, and …

Regulation Of Human Dna Mismatch Repair, Breanna Knicely

Theses and Dissertations--Toxicology and Cancer Biology

The DNA mismatch repair (MMR) pathway identifies and corrects misincorporations that arise during DNA replication. MMR is a pathway that is critical for maintaining genomic stability. Mutations within the MMR pathway, both germline and somatic, lead to the development of cancer. There are a variety of mechanisms that regulate the MMR pathway including protein-protein interactions, DNA damage response, and post-translational modifications. In this study, we aim to dive deeper into each of these mechanisms to obtain novel information regarding the mechanisms and regulation of human DNA MMR. In this study we generated hExo1 constructs mutating Exo1’s interactions with MSH2 and …