Medicine and Health Sciences Commons^™

Daily Glucocorticoids Promote Glioblastoma Growth And Circadian Synchrony To The Host, Maria F Gonzalez-Aponte, Anna R Damato, Tatiana Simon, Nigina Aripova, Fabrizio Darby, Myung Sik Jeon, Jingqin Luo, Joshua B Rubin, Erik D Herzog

2020-Current year OA Pubs

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a poor prognosis despite aggressive therapy. Here, we hypothesized that daily host signaling regulates tumor growth and synchronizes circadian rhythms in GBM. We find daily glucocorticoids promote or suppress GBM growth through glucocorticoid receptor (GR) signaling depending on time of day and the clock genes, Bmal1 and Cry. Blocking circadian signals, like vasoactive intestinal peptide or glucocorticoids, dramatically slows GBM growth and disease progression. Analysis of human GBM samples from The Cancer Genome Atlas (TCGA) shows that high GR expression significantly increases hazard of mortality. Finally, mouse …

Meta-Analysis Of Dedicated Vs Off-Label Transcatheter Devices For Native Aortic Regurgitation, Sahar Samimi, Taha Hatab, Chloe Kharsa, Safi U Khan, Rody G Bou Chaaya, Fatima Qamar, Joe Aoun, Syed Zaid, Nadeen Faza, Marvin D Atkins, Stephen H Little, William A Zoghbi, Michael J Reardon, Neal S Kleiman, Sachin S Goel

Faculty, Staff and Students Publications

Background: Transcatheter aortic valve replacement (TAVR) for high surgical risk patients with severe native aortic regurgitation (AR) presents unique challenges. Dedicated devices such as the JenaValve (JenaValve Technology) and J-Valve (JC Medical Inc) show promising results in addressing these challenges.

Objectives: This study compares the safety and efficacy of dedicated vs off-label devices among high surgical risk patients with pure native AR.

Methods: We systematically searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials through July 11, 2024, for studies on TAVR among patients with pure severe native AR. The primary endpoint was 30-day all-cause mortality. Secondary endpoints were …

Mobility Task Shows Rescue Of Scotopic Vision In A Swine Model For Autosomal Dominant Retinitis Pigmentosa After Treatment With The Meganuclease Rho 1-2, Gita Jaikumar, Jack Feist, Kautuk Kamboj, Aravind Kumar, Francesca Barone, Archana Jalligampala, Wei Wang, Jeff Smith, Dave Morris, Derek Jantz, Victor Bartsevich, Kristi Viles, Maureen Mccall

Posters-at-the-Capitol

Purpose : Retinitis pigmentosa (RP) is the most common form of inherited retinal disease with ~1:5000 people affected worldwide. The substitution of Proline to Histidine (P23H) at position 23 in the rhodopsin protein is the most common form of adRP in North America. We have shown that treating a transgenic P23H human RHO pig model of adRP (TgP23H hRHO) with a gene-editing meganuclease Rho 1-2, recovers rod structure and restores rod function. We ran WT, Rho1-2 treated and untreated TgP23H hRHO (Tg) pigs through an obstacle course to quantify visually guided mobility under light- and dark-adapted conditions using motion analysis …

Greece And Harm Reduction Efficacy, Callie Wagers

Posters-at-the-Capitol

An overview of the significance of harm reduction strategies in public health, highlighting Greece's innovative approaches recognized by the Healthy Cities Award. Harm reduction encompasses a range of policies and programs designed to minimize the negative health and social impacts associated with substance use, emphasizing pragmatic and compassionate solutions rather than punitive measures. Greece's successful initiatives—such as syringe exchange programs, supervised consumption sites, and comprehensive addiction treatment services—serve as a model for addressing public health crises. Kentucky, facing significant challenges related to substance use disorders, can adopt and adapt Greece's harm reduction methods to enhance the well-being of its communities. …

Analyzing Whether Different Types Of Taste Nerve Fibers Have Different Innervation Patterns Through Proximity And Colocalization, Abdel-Rhman M. Al-Azzawi

Posters-at-the-Capitol

The taste system not only allows us to perceive and distinguish various flavors but also plays a vital role in detecting nutrients and avoiding toxins. However, the precise organization of the neurons that convey taste information to the brain remains largely unknown, making it a critical area of research This study aims to determine if different types of taste neurons (as determined by genetic expression) exhibit distinct innervation patterns. This was accomplished by analyzing their proximity and colocalization with different types of taste bud cells. Taste bud cell types include Type II cells, which detect sweet, bitter, and umami flavors, …

Ct-Based Visualization Of Aortic Valve Morphology: From 3d Energy-Integrating Ct To 4d Photon Counting Ct, Alison M. Pouch, Jessie N. Dong, Harold I. Litt, Brittany J. Cannon, Melanie Freas, Victor Ferrari, Thomas G. Gleason, Matthew A. Jolley, Natalie Yushkevich, Jessica Nunez, Jilei Hao, Zaiyang Guo, Shir Goldfinger, John Kelly, Joseph E. Bavaria, Nimesh D. Desai

Division of Cardiology Faculty Papers

BACKGROUND: While 4D contrast-enhanced computed tomography (CT) is used to plan cardiovascular interventions such as transcatheter valve replacement, it is not yet routinely used to characterize minimally calcified aortic valves for planning of surgical valve repair. It is widely recognized that aortic valve morphology has implications for the durability of valve repair surgery.

PURPOSE: The objective is to demonstrate the potential of CT image segmentation for elucidating aortic valve morphology prior to surgery and to illustrate a potential benefit of 4D CT and photon counting CT (PCCT) for patient-specific modeling of dysmorphic aortic valves.

MATERIALS AND METHODS: This observational series …

Is Modulation Of Immune Checkpoints On Glioblastoma-Infiltrating Myeloid Cells A Viable Therapeutic Strategy?, Ruochen Du, Jianzhong Zhang, Rimas V Lukas, Shashwat Tripathi, Jared T Ahrendsen, Michael A Curran, Crismita Dmello, Peng Zhang, Roger Stupp, Ganesh Rao, Amy B Heimberger

Faculty, Staff and Students Publications

The field of immunology has traditionally focused on immune checkpoint modulation of adaptive immune cells. However, many malignancies such as glioblastoma are mostly devoid of T cells and rather are enriched with immunosuppressive myeloid cells of the innate immune system. While some immune checkpoint targets are shared between adaptive and innate immunity, myeloid-specific checkpoints could also serve as potential therapeutics. To better understand the impact of immune checkpoint blockade on myeloid cells, we systematically summarize the current literature focusing on the direct immunological effects of PD-L1/PD-1, CD24/Siglec-10, collagen/LAIR-1, CX3CL1/CX3CR1, and CXCL10/CXCR3. By synthesizing the molecular mechanisms and the translational implications, …

Neurocognitive Outcomes And Functional Independence In Adult Survivors Of Childhood Medulloblastoma Diagnosed Over 3 Decades, Chiara Papini, Sedigheh Mirzaei, Mengqi Xing, Ingrid Tonning Olsson, Ralph Salloum, Peter M K De Blank, Katharine R Lange, Tricia Z King, Deokumar Srivastava, Wendy M Leisenring, Rebecca M Howell, Kevin C Oeffinger, Leslie L Robison, Gregory T Armstrong, Kevin R Krull, Tara M Brinkman

Faculty, Staff and Student Publications

Background: Treatment of childhood medulloblastoma has evolved to reduce neurotoxicity while improving survival. However, the impact of evolving therapies on late neurocognitive outcomes and adult functional independence remains unknown.

Methods: Adult survivors of childhood medulloblastoma (n = 505; median [minimum-maximum] age, 29 [18-46] years) and sibling controls (n = 727; 32 [18-58] years) from the Childhood Cancer Survivor Study completed surveys assessing neurocognitive problems and chronic health conditions (CHCs). Treatment exposures were categorized as historical (craniospinal irradiation [CSI] ≥ 30 Gy, no chemotherapy), standard-risk (CSI > 0 to < 30 Gy + chemotherapy) and high-risk (CSI ≥ 30 Gy + chemotherapy) therapy. Latent class analysis identified patterns of functional independence using employment, independent living, assistance with routine/personal care needs, driver's license, and marital/partner status. Multivariable models estimated the risk of neurocognitive impairment in survivors versus siblings and by treatment exposure group, and associations between neurocognitive impairment, CHCs, and functional independence.

Results: Survivors in each treatment exposure group had a 4- to 5-fold elevated …

Pharmacological Or Genetic Inhibition Of Ltcc Promotes Cardiomyocyte Proliferation Through Inhibition Of Calcineurin Activity, Lynn A C Devilée, Abou Bakr M Salama, Jessica M Miller, Janice D Reid, Qinghui Ou, Nourhan M Baraka, Kamal Abou Farraj, Madiha Jamal, Yibing Nong, Todd K Rosengart, Douglas Andres, Jonathan Satin, Tamer M A Mohamed, James E Hudson, Riham R E Abouleisa

Faculty, Staff and Students Publications

Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their limited proliferative capacity. Calcium is an important signal transducer that regulates key cellular processes, but its role in regulating CM proliferation is incompletely understood. Here we show a robust pathway for new calcium signaling-based cardiac regenerative strategies. A drug screen targeting proteins involved in CM calcium cycling in human embryonic stem cell-derived cardiac organoids (hCOs) revealed that only the inhibition of L-Type Calcium Channel (LTCC) induced the CM cell cycle. Furthermore, overexpression of Ras-related associated with Diabetes (RRAD), an endogenous inhibitor of LTCC, induced CM cell cycle …

Dissecting The Binding Affinity Of Anti-Sars-Cov-2 Compounds To Human Transmembrane Protease, Serine 2: A Computational Study, Yue-Hui Shi, Jian-Xin Shen, Yan Tao, Yuan-Ling Xia, Zhi-Bi Zhang, Yun-Xin Fu, Ke-Qin Zhang, Shu-Qun Liu

Faculty, Staff and Student Publications

The human transmembrane protease, serine 2 (TMPRSS2), essential for SARS-CoV-2 entry, is a key antiviral target. Here, we computationally profiled the TMPRSS2-binding affinities of 15 antiviral compounds. Molecular dynamics (MD) simulations for the docked complexes revealed that three compounds exited the substrate-binding cavity (SBC), suggesting noncompetitive inhibition. Of the remaining compounds, five charged ones exhibited reduced binding stability due to competing electrostatic interactions and increased solvent exposure, while seven neutral compounds showed stronger binding affinity driven by van der Waals (vdW) interactions compensating for unfavorable electrostatic effects (including electrostatic interactions and desolvation penalties). Positive and negative hotspot residues were identified …

Conformational Switching Of Arp5 Subunit Regulates Ino80 Chromatin Remodeling, Shagun Shukla, Somnath Paul, Jeison Garcia, Yuan Zhong, Sara Sanz Juste, Karissa Beauchemin, Blaine Bartholomew

Faculty, Staff and Student Publications

The INO80 chromatin remodeler is a versatile enzyme capable of several functions, including spacing nucleosomes equal distances apart, precise positioning of nucleosomes based on DNA shape/sequence and exchanging histone dimers. Within INO80, the Arp5 subunit plays a central role in INO80 remodeling, evidenced by its interactions with the histone octamer, nucleosomal and extranucleosomal DNA, and its necessity in linking INO80's ATPase activity to nucleosome movement. We find two distinct regions of Arp5 binding near the acidic pocket of nucleosomes. One region has an arginine anchor that binds nucleosomes and is vital for INO80 mobilizing nucleosomes. The other region has a …

Hyperleukocytosis In A Neuroblastoma Patient After Treatment With Natural Killer T Cells Expressing A Gd2-Specific Chimeric Antigen Receptor And Il-15, Gengwen Tian, Amy N Courtney, Hangjin Yu, Saleh Bhar, Xin Xu, Gabriel A Barragán, Claudia Martinez Amador, Nisha Ghatwai, Michael S Wood, Deborah Schady, Antonino Montalbano, Shantan Reddy, Aoife M Roche, David De La Cerda, Donald Williams Parsons, Erica J Di Pierro, Frederic D Bushman, Andras Heczey, Leonid S Metelitsa

Faculty, Staff and Students Publications

The ability of immune cells to expand numerically after infusion distinguishes adoptive immunotherapies from traditional drugs, providing unique therapeutic advantages as well as the potential for unmanageable toxicities. Here, we describe a case of lethal hyperleukocytosis in a patient with neuroblastoma treated on phase 1 clinical trial (NCT03294954) with autologous natural killer T cells (NKTs) expressing a GD2-specific chimeric antigen receptor and cytokine interleukin 15 (GD2-CAR.15). This patient was the first to be treated on dose level (DL) 5 and the first patient whose product was restimulated with K562-derived artificial antigen-presenting cells (aAPCs) instead of autologous peripheral blood mononuclear cells …

Cannabis Use Characteristics And Associations With Problematic Use Outcomes, Quitting-Related Factors, And Mental Health Among Us Young Adults, Carla J Berg, Cassidy R Loparco, Katelyn F Romm, Yuxian Cui, Darcey M Mccready, Yan Wang, Y Tony Yang, Hannah S Szlyk, Erin Kasson, Rishika Chakraborty, Patricia A Cavazos-Rehg

2020-Current year OA Pubs

OBJECTIVE: Given the changes in trends of cannabis use (e.g., product types), this study examined latent classes of young adult use and associations with use-related outcomes.

METHODS: We analyzed 2023 survey data among 4,031 US young adults (M

RESULTS: LCA identified 4 classes of cannabis use frequency and types used: 'infrequent-herb/edibles' (41.4%), 'frequent-herb' (16.8%), 'moderate-herb' (28.0%), and 'moderate-oil/other' (13.8%). In multivariable analyses (referent group: 'moderate-herb' class), 'frequent-herb' reported less problematic use (B=-0.18, 95%CI=-0.30, -0.07), while 'moderate-oil/other' reported greater (B = 0.39, 95%CI = 0.27, 0.51). 'Infrequent-herb/edibles' had lower odds of driving post-use of cannabis (aOR = 0.28, 95%CI = 0.22, …

Medical Muse, Unm Health Sciences Center

Medical Muse

A literary journal devoted to the inquiries, experiences, and meditations of the University of New Mexico Health Sciences Center community.

This edition has wonderful contributions that underline why this journal exists. The idea of writing about our challenges, life experiences, and our missions in medicine create teaching and healing for the reader and the writer. I direct the reader to the essays entitled “3 Women” and “Pronouncement” as both pieces underline what the UNM Medical Muse is all about. Writing about one’s experiences as in “3 Women” as well as the lovely “how to” description of cultural competence in “Pronouncement” …

Using Nanotechnology To Achieve Sustainability In Interior Residential Spaces, Neveen Youssef Azmy, Esraa Tarek Abu-El Azm, Ahmed Ahmed Rizk, Walaa Abou El-Haggag Mehanna

Journal of Engineering Research

Major scientific and technological developments characterize the present time. One notable achievement is the nano revolution, which has greatly influenced various areas of life Nanotechnology is characterized by using very small particles of materials, either alone or by processing them to create new materials with remarkable properties. Hence, nanotechnology offers promising economic solutions and products to achieve a reliable and sustainable environment. Architecture has great potential to benefit from this technology to achieve sustainability and improve indoor environment quality. Given the proliferation of residential buildings in urban areas, where people spend most of their time, it is necessary to integrate …

Evaluating Lidar Technology In Iphone Mobiles For 2d Mapping Applications, Nasr Mohammady Saba, Salem Salama Saleh

Journal of Engineering Research

Abstract- LiDAR (Light Detection and Ranging) technology has revolutionized mapping applications, offering enhanced precision and accuracy in spatial data collection. The integration of LiDAR technology in the latest iPhone models, beginning with the iPhone 12 Pro, has introduced new capabilities for 2D data measurement and plan creation directly on the mobile device. The iPhone 12 Pro and 12 Pro Max models support LiDAR techniques within their mobile phone cameras, enhancing the performance of various applications such as Measurements and Photos. LiDAR operates by emitting pulsed light waves into the surrounding space, which bounce off nearby objects and return to the …

Experimental And Numerical Investigation For Optimum Design Of Hydraulic Steel Gates, Basma Hassan Mohamed Eng, Ahmed Mohamed Anwer Dr, Hanan Eltobgy Prof., Gamal Helmy El-Saeed Prof

Journal of Engineering Research

Conventionally, steel gates are widely used in hydraulic structures for their superior mechanical properties in sustaining hydrostatic pressure. Maintenance and operational costs should be considered while studying the feasibility of these gates. In the current research, three prototype steel gates with different configurations were prepared and examined experimentally. The three gates have the same surface dimensions of (width x height) equal to (1.0 x 1.25 m). The first steel gate represents a typical traditional gate made of skin plate and stiffened laterally using standard steel channels and will be kept for comparison. The second gate represents a standard thicker plate …

Performance And Emissions Characteristics Of Multi-Cylinder Direct Injection Diesel Engine Fuelled With Diesel/Biodiesel And Toluene Additives, Hagar Alm-Eldin Bastawissi, Medhat Elkelawy Prof. Dr. Eng., Mohammed Osama Elsamadony Dr. Eng., Moustafa Ghazaly Eng.

Journal of Engineering Research

This study explores the impact of using a diesel, biodiesel, and toluene additive fuel blend in a multi-cylinder direct injection diesel engine, focusing on both performance and emissions characteristics. Biodiesel, made from renewable sources like vegetable oils, is often added to diesel to reduce reliance on fossil fuels and improve combustion due to its higher oxygen content. In this work, a 45% biodiesel blend (B45) led to significant reductions in particulate matter (PM) emissions by up to 40% compared to conventional diesel. Additionally, carbon monoxide (CO) and hydrocarbon (HC) emissions decreased by up to 30% and 25%, respectively, due to …

Effect Of Dual-Fuelled Cng And Gasoline On Spark Ignition Engine Performance And Emissions Behaviors At Different Loads, Medhat Elkelawy Prof. Dr, Eng., M.M. Bassuoni Prof. Dr., Hagar Alm-Eldin Bastawissi, Saied I. Haiba Eng.

Journal of Engineering Research

Engine emissions are one of numerous factors that have detrimentally affected the environment, such as global warming, which is the result of growing exhaust gases, practically carbon dioxide (CO2). These emissions have substantially influenced researchers to develop strategic initiatives to minimize the carbon contents of fuels. The purpose of this research is to investigate the characteristics of internal combustion (SI) engines fueled by gasoline and compressed natural gas (CNG) blends. The experiments are performed using a HONDA 4-stroke, single-cylinder, and air-cooled SI engine. Five CNG concentrations are evaluated, the concentrations range from 0.5 to 2.5 L/min with a 0.5 L/min …

A Quantitative Analysis Of The Commercial-Additive Effects On Diesel Engine Combustion And Emissions Characteristics, Medhat Elkelawy Prof. Dr. Eng., Hagar Alm-Eldin Bastawissi Prof. Dr. Eng., E. A. El Shenawy Prof. Dr., Mahmoud Mohamed Soliman Mahmoud Mohamed Mahmoud Soliman

Journal of Engineering Research

Petroleum fuel prices fluctuate in response to global political and economic issues. Government regulations should be followed when it comes to engine emissions, as these dangerous pollutants have a negative impact on the environment. One such effect is global warming, which raises global temperatures. The purpose of this study is to develop the additives for use as a fuel mix with diesel fuel, which will be used to feed the diesel engine of a single cylinder, four strokes. The engine will be tested experimentally with varying loads at fixed speed of 1500 rpm, using blends of [(5% PRETSONE additive + …

Design And Implementation Of A Low-Cost Educa-Tional Robot For Engineering Curriculums, Diana Refaat Henry Jacob, Ashraf Mohamed Hafez, Mohamed Tarek Elawa

Journal of Engineering Research

The role of educational robots is becoming increasingly important. Many commercial educational robots differ in their abilities and price. In general, the cost of these robots presents the main cause of their limited use in the teaching process, especially in countries with limited financial resources. This work attempts to solve this problem by designing and implementing an educational robot with a limited budget. The robot was initially intended to serve higher education students' needs, especially in engineering curriculums but can be extended to other application areas. This work presents robot hardware functional blocks, mechanical struc-ture design, and 3D printing implementation. …

A Greening The Diesel: Vegetable Oil Biodiesel Blends For Cleaner Emissions And Improved Direct Injection Diesel Engine Performance, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi, E. A. El Shenawy Prof. Dr., Mustafa Mohamed Ouda

Journal of Engineering Research

In this study, we conducted comprehensive experiments to assess and compare the performance of pure diesel fuel against biodiesel produced from corn oil in various blend ratios (15/85, 30/70, 45/55, and 60/40) in a conventional four-stroke, direct-injection diesel engine, fuel is injected directly into the combustion chamber at the end of the compression stroke, allowing for efficient combustion and power generation over four distinct phases: intake, compression, power, and exhaust. Each fuel blend was tested at an engine speed of 16,000 rpm across different load conditions (low, medium, and high). Key performance metrics, including volumetric fuel consumption, exhaust smoke, and …

Case Report: Adult Patient With Acquired Apraxia Of Speech Secondary To A Stroke In Broca's Area, Richard Zraick

UCF Created OER Artifacts

This open educational resource (OER) is a case report about an adult patient with acquired apraxia of speech secondary to stroke in Broca's area. This case report was originally developed for SPA 6236: Motor Speech Disorders, School of Communication Sciences & Disorders, University of Central Florida, by Richard Zraick, Ph.D., CCC-SLP, F-ASHA. The content was based on output from ChatGPT and generated with the prompt: “Create a fictional case report for an adult patient with acquired apraxia of speech secondary to cerebrovascular accident in Broca’s area.” Others are free to reuse this OER to distribute, remix, adapt, and build upon …

Morphological And Scanning Electron Microscopy Characterization Of A Spirurid In A Wild Sunda Pangolin (Manis Javanica), Punnarat Vibulchan, Chong Shin Min, Chiharu Okumura, Piyanan Taweethavonsawat

The Thai Journal of Veterinary Medicine

This study identifies and characterizes a spirurid in a wild Sunda pangolin (Manis javanica) using scanning electron microscopy (SEM). Native to Southeast Asia, the Sunda pangolin faces critical threats from poaching, illegal trafficking for its scales and meat, habitat loss, urban conflicts, and disease. Despite this, little is known about the biology of wild Sunda pangolins. In this research, spirurid parasites were recovered from a pangolin fatally injured in a vehicular collision. The parasites were preserved and analyzed with SEM, revealing key morphological features such as papillae, lip-like structures, and an anal opening in females. This study enhances …

Correlation Of Classical Swine Fever (Csf) Antibody Protective Level Detected By Enzyme-Linked Immunosorbent Assay And Serum Neutralization Test, Chairani Ridha Maghfira, Nguyen Thanh Che, Apisit Kittawornrat, Roongroje Thanawongnuwech, Yaowalak Panyasing

The Thai Journal of Veterinary Medicine

Protective antibody against classical swine fever virus (CSFV) is an important parameter used for disease monitoring in CSFV-endemic areas. Enzyme-linked immunosorbent assay (ELISA) is a simple and practical serological assay for CSFV antibody detection. However, the use of CSFV ELISAs in CSFV antibody-positive herds, i.e., CSFVvaccinated or -previously infected herds, was limited by an application of the test results. This study aimed to evaluate the correlation and estimation of protective antibody levels detected by ELISA and serum neutralization assay. A total of 522 negative and positive serums were tested by SN and ELISA in parallel. Comparisons of sample-to-positive (S/P) values …

How To Help New Nurses Deal With Anxiety And Stress, Jared Modzelewski Bsn, Rn

Posters

Background

New graduate nurses need to reduce their stress and anxiety to improve patient outcomes. Every nurse has some anxiety and stress, but new graduate nurses have been talking about it more. This change is necessary because improvement in mental health for nurses can improve their wellbeing and the overall quality of care they provide their patients.

Exploring The Impact Of Biological Sex On Intrinsic Connectivity Networks In Ptsd: A Data-Driven Approach., Andrew A Nicholson, Jonathan M Lieberman, Niki Hosseini-Kamkar, Kristen Eckstrand, Daniela Rabellino, Breanne Kearney, David Steyrl, Sandhya Narikuzhy, Maria Densmore, Jean Théberge, Fardous Hosseiny, Ruth A Lanius

Medical Biophysics Publications

INTRODUCTION: Sex as a biological variable (SABV) may help to account for the differential development and expression of post-traumatic stress disorder (PTSD) symptoms among trauma-exposed males and females. Here, we investigate the impact of SABV on PTSD-related neural alterations in resting-state functional connectivity (rsFC) within three core intrinsic connectivity networks (ICNs): the salience network (SN), central executive network (CEN), and default mode network (DMN).

METHODS: Using an independent component analysis (ICA), we compared rsFC of the SN, CEN, and DMN between males and females, with and without PTSD (n = 47 females with PTSD, n = 34 males with PTSD, …

Developing Real-Time, Online Beam Control Of Uhdr Irradiators To Facilitate Flash Translational Investigations, Austin M. Sloop

Dartmouth College Ph.D Dissertations

The field of radiation oncology seeks novel techniques to increase the therapeutic ratio to treat malignancies while minimizing damage and toxicities in healthy tissues. While it was observed that delivering therapeutic doses at high dose rate could elicit lower biological effects over a half-century ago, the field of ultra-high dose rate (UHDR) radiation therapy (colloquially known as FLASH RT) has seen a resurgence in recent years due to an alignment of accelerator capability, dosimetric advances, and improved biotechnological techniques. This has opened the door to studying potential underlying mechanisms such that we may leverage the effects of FLASH tissue sparing …

A Practical Guide To Grade Adjustment Or Curving For Pharmacy And Other Professional Health Programs, Reza Mehvar

Pharmacy Faculty Articles and Research

The peer-reviewed literature on the adjustment or curving of assessments in health profession programs is almost non-existent. This communication aims to present potential methods of grade adjustment for individual questions or entire assessments. Simulated data for a 25-item assessment were used as an example to analyze the effects of different methods of grade adjustment on students’ scores. Grade adjustments were made by adjusting the points for individual questions or the scores for the entire assessment. Adjustment for the individual questions was carried out by dropping the question, adding points to those who missed the question, or adding a bonus point …

Resistance Training Versus Cardiovascular Training: Which Is Better For Fat Loss?: A Brief Narrative Review., Jason M. Curtis, Jose Antonio, Cassandra Evans

Journal for Sports Neuroscience

Abstract

Introduction: Obesity has risen from 30.5% to 41.9% from 2000-2017. Those who are considered severely obese increased from 4.7% to 9.2% over that same period. There are numerous fitness-center approaches to induce weight-loss or reduction of body fat. These interventions are often categorized into two general categories: Resistance training (using weighted resistance in anaerobic strength training) and cardiovascular training (aerobic training). While both fitness groups have been shown to be effective, there is a debate about which method is most effective for eliciting changes in body composition, primarily fat loss.

Methods: Google Scholar and Pubmed were scoured for …