Medicine and Health Sciences Commons^™

The Tie2 Antagonist Rebastinib Reduces Ovarian Cancer Growth In A Syngeneic Murine Model, Vijayalaxmi G Gupta, Katherine F Roby, Harsh B Pathak, Andrew K Godwin, Sumedha Gunewardena, Dineo Khabele

2020-Current year OA Pubs

BACKGROUND: The receptor tyrosine kinase TIE2 and its ligands, angiopoietins (ANGPTs), promote angiogenesis. In addition to expression on vascular endothelial cells, TIE2 is expressed on M2-like pro-tumorigenic macrophages. Thus, the TIE2 inhibitor rebastinib was developed as a potential therapy to address multiple cancers. The objective of this study was to determine the effects of rebastinib alone and combined with chemotherapy in a syngeneic murine model of ovarian cancer.

METHODS: Female C57Bl6J mice were intraperitoneally injected with syngeneic ID8 ovarian cancer cells. Once tumors were established, mice were untreated (control) or treated with rebastinib, carboplatin plus paclitaxel (chemotherapy), or rebastinib plus …

2024 Physician-Scientist Trainee Diversity Summit Conference Proceedings, Jessica Weng, Cynthia Y Tang, Kyle T Enriquez, Rohini N Guin, Briana Christophers, Yentli E Soto Albrecht, Daniel B Amusin, Deborah D Rupert, Paige Cooper Byas

2020-Current year OA Pubs

The Physician-Scientist Trainee Diversity Summit, hosted by the American Physician Scientists Association and the Burroughs Wellcome Fund, was conceived in 2019 with the mission of developing strategic plans to diversify the physician-scientist community using human-centered design thinking. In June 2024, the second iteration of this conference was held in Raleigh, North Carolina, and brought together a network of scientific and medical organizations to discuss issues of justice, equity, diversity, and inclusion facing physician-scientist trainees. This article summarizes the progress made from the first meeting, the proceedings of the 2024 Summit, and a thematic analysis of the recent meeting, offering tangible …

External Apical Root Resorption In Orthodontics, Morgan Mecham, Shilpa Bhandi, Shankargouda Patil, Frank Licari

Annual Research Symposium

No abstract provided.

Sustainable Smiles: Green Orthodontics For A Better Tomorrow, Arzu Manochehri, Shilpa Bhandi, Frank W. Licardi, Shankargounga Patil

Annual Research Symposium

No abstract provided.

Bridging The Gap: Miniscrew-Assisted Palatal Expansion In A Non-Growing Patient: A Case Report, Jacob Thomas, Ms Ravi, Suraj Prasad Sinha

Annual Research Symposium

This case report describes the treatment of transverse maxillary deficiency using a Miniscrew-Assisted Rapid Palatal Expander (MARPE) appliance. MARPE is an innovative non-surgical appliance designed to expand the maxillary arch through skeletal and dentoalveolar modification.

Investigating The Impact Of Tirzepatide Treatment On Alcohol And Cigarette Consumption, Yvannia Gray, Benjamin Latey, Hayden Mcaffee, Karissa Mccown, Seth Maki, Victoria Nguyen, Andrew Payne

Annual Research Symposium

No abstract provided.

Transcranial Magnetic Stimulation As A Treatment Modality For Functional Bowel Disorder And Irritable Bowel Syndrome And Possible Correlations With The Gut-Brain Axis: A Review, Lauren Draper, Devin Pfister, Ethan Zaugg

Annual Research Symposium

Functional Bowel Disorders (FBD), including Irritable Bowel Syndrome (IBS), are highly prevalent gastrointestinal conditions classified as Disorders of Gut-Brain Interactions (DGBIs) under the Rome IV criteria. These conditions, marked by abdominal pain, altered bowel habits, and significant psychological comorbidities, present substantial challenges in both diagnosis and treatment. Conventional therapies primarily target gut-centric mechanisms but often yield limited efficacy, underscoring the need for approaches that account for the complex interplay of the gut-brain axis in DGBI pathophysiology.

Dental Pulp-Derived Stem Cells Applied For Tissue Rehabilitation Could Increase The Risk Of Recurrence In Oral Cancer Patients: Evidence From In-Vitro Analysis, Thirumal Raj, Supriya Kheur

Annual Research Symposium

No abstract provided.

Exploring The Therapeutic Potential Of Resveratrol In Substance Use Disorders: A Systematic Review Of Its Effects On Kcc2 Expression, Lauren R. Nelson, Ashlyn Hughes, Jory Winward, Natalie Phanco, Andrew Payne Phd

Annual Research Symposium

No abstract provided.

Anesthesia And Pain Management In Conflict-Affected Regions: Addressing Global Health Barriers To Access And Quality Of Care​, Naeel Uddin, Sierra Brown, Maria Easler, Ayanda Mkhize, Marwa Hamdam, Chandu Goli, Lauren Draper

Annual Research Symposium

This poster examines how to deliver safe, effective anesthesia and pain control in areas with limited resources and ongoing security threats. Focusing on portable technology, ketamine-based protocols, and telemedicine, we highlight ethical considerations, training needs, and global collaborations. Our findings outline a pathway to reduce suffering and improve surgical outcomes in vulnerable populations by addressing challenges unique to conflict settings.

Orthodontic Correction Of Bimaxillary Protrusion Using Mbt And Frictionless Retraction: A Case Report, Sai Kalyan Menta, Ms Ravi

Annual Research Symposium

The present poster is about a case report of class I bimaxillary protrusion patient, orthodontically treated by extracting all four premolars and retracted using frictionless mechanics (Tear drop loop).

Investigating The Effects Of Resveratrol On Opioid-Induced Hyperalgesia, Bryana Cox, Thien Do, Ashlyn Hughes, Zane Kingsbury, Keara Leroy, Andrew J. Payne

Annual Research Symposium

Opioid-induced hyperalgesia (OIH) is an adverse effect of chronic opioid therapy, characterized by increased sensitivity to pain. This study will seek to determine if using resveratrol supplementation as an indirect enhancer to increase the expression of the KCC2 membrane transporter can alleviate the symptoms of OIH in human subjects.

Effect Of Biomineralizing Bulk Fill Restoratives On The Functional Properties Of Occlusomesial Restorations Invitro, Thilla Sekar Vinothkumar, Apathsakayan Renugalakshmi

Annual Research Symposium

No abstract provided.

Holistic Management Of Glucose Dysregulation Mimicking Autoimmune Disease: Case Investigation, Jacob Warner-Palacio, Hannah Hunsaker, Julian Warner-Palacio, Amanda Mckenna-Larson, Brigita Budginas, Alexander Tam, Levi Fridricksson, David Sant, Kyle Bills

Annual Research Symposium

No abstract provided.

Use Of Synthetic Water-Soluble Kcc2 To Modulate Chloride Homeostasis In Cultured Dopamine-Neuron-Like Cells, Mason Terry, Andrew Payne, Dario Mizrachi

Annual Research Symposium

No abstract provided.

Unraveling Physiologic Mechanisms In Passive And Active Mechanoreceptor Stimulation, Halah Khan, Braden Ashcraft

Annual Research Symposium

No abstract provided.

Evaluating Workflow Efficiency: Two-Day Versus One-Day Pre-Planning In Outpatient Infusion Clinics, Amber Escobedo, Kent Wood, Danielle Gundrum, Kelsey Brown, Allie Snoke, Trenna Weathers

Annual Research Symposium

No abstract provided.

Efficacy Of Biodegradable Natural Fibers Infused Toothbrushes In Plaque Control And Gingival Health: A Double Blind Randomized Control Clinical Trial, Shazneen Kandawalla

Annual Research Symposium

Title: Efficacy of Biodegradable Natural fibers-Infused Toothbrushes in Plaque Control and Gingival Health: A Comparative Study

Background: Plaque removal is crucial for preventing gingivitis and periodontitis. Biodegradable toothbrushes, infused with natural substances like charcoal and neem, provide an eco-friendly alternative to conventional nylon brushes. Charcoal offers antibacterial properties, while neem provides antimicrobial and anti-inflammatory benefits.

Aim: To evaluate and compare the antiplaque and anti-inflammatory effects of charcoal-infused and neem-infused toothbrushes with conventional toothbrushes.

Methods: This double-blind randomized controlled trial included 33 systemically healthy individuals diagnosed with gingivitis. Baseline plaque scores were set to zero through professional scaling. Subjects were randomly …

A Morphological Investigation Of Alcohol-Induced Persister Formation, Isaac Young, Victor Jimenez

Annual Research Symposium

No abstract provided.

The Opportunities And Barriers Surrounding The Use Of Digital Health And Telemedicine In Sub-Saharan Africa, Aveline Langmead, Afua Osei-Wusu, Erica Tutuwan, Sara Mcmahon, Porter Biggs

Annual Research Symposium

No abstract provided.

Temporary Anchorage Devices: The Cornerstone Of Precision In Orthodontics, Aman Preet Kaur, Shilpa Bhandi, Frank W. Licari, Shankargouda Patil

Annual Research Symposium

No abstract provided.

Effects Of Hvla On Shoulder Mobilization And Baseball Pitch Velocity With Dari Motion Capture, Drew T. Mortensen, James Barber, Jordyn Huecker, Garret Phillips, Jayne Stuter, Braden Ashcraft, Isabella Termini, Victoria Oyeniyi, Christina Small, Kyle Bills

Annual Research Symposium

No abstract provided.

Identifying Breathing, Swallowing, And Speech Biosignatures In Parkinson’S Disease Patients With Wearable Devices, Amanda Brandaris, Katherine Shishido, Rohaan Manzoor, Ethan Hampton, Karthik Jasty, Kelvin Guo, Anna Fish, Spencer Peterson, Ulrike H. Mitchell Phd, Phillip Sechtem Phd, Ccc-Slp, Paula Johnson Phd, Anton E. Bowden Phd, Miriam Cortez-Cooper Pt, Phd, Pamela I. Barney Msrt, Rrt, Ae-C, Nps, John A. Kriak Pharmd

Annual Research Symposium

No abstract provided.

A Galleria Mellonella Study: Protective Effects Of Sulforaphane On Immune Function In Binge Alcohol Exposure, Robert Kento Darby, Braydon Black, Vincent Tran, Dallen James, Scott Quimby

Annual Research Symposium

Alcohol is associated with increased mortality and morbidity. Pulmonary infections with opportunistic pathogens can occur in healthy humans; however, hazardous alcohol exposure like binge alcohol intoxication (≥ 0.08% BAC) is a major risk factor. We’ve previously investigated the efficacy of Sulforaphane (SFN) prophylaxis in protecting human and murine alveolar macrophage function against opportunistic infections when exposed to binge alcohol conditions in vitro. However, an in vivo model investigating SFN and hazardous alcohol exposure in the context of infection is not well understood. The aim of this study is to 1) establish a G. mellonella larvae model by determining the LD50 …

Investigating Biomarkers Of Anxiety Amelioration With Heterodyned Whole-Body Vibration Using Eeg​, Jaxson Bowen, Aaron Andrews, James Barber, James Fini, Erik Gardner, Lorissa Thorpe, Braden Ashcraft, Christina Small, Kyle Bills

Annual Research Symposium

No abstract provided.

Accessories And Bifurcations: A Cadaveric Case Study Of Unilateral Accessory Renal Arteries ​, Talia Swanke, Carter Anderson, Chaitanya Cherukupalli, Markell Pond, Jared Salehi, Chasity Simmons, Courtney Sloss-Garza, Carlos E. Angulo

Annual Research Symposium

A cadaveric dissection conducted at Noorda College of Osteopathic Medicine revealed atypical renal vasculature findings.

Exploring Acgme-Accredited Electrophysiology Fellowship Website Information Using Eras, Lorissa Thorpe, Jacob Lahti, Thomas Varkey, Ceanna Potter

Annual Research Symposium

EP Fellowships

Axl Signaling In Cancer: From Molecular Insights To Targeted Therapies, Monika Yadav, Akansha Sharma, Ketki Patne, Saba Tabasum, Jyoti Suryavanshi, Laxminarayan Rawat, Marc Machaalani, Marc Eid, Rana Singh, Toni Choueiri, Soumitro Pal, Akash Sabarwal

Department of Microbiology and Immunology Faculty Papers

AXL, a member of the TAM receptor family, has emerged as a potential target for advanced-stage human malignancies. It is frequently overexpressed in different cancers and plays a significant role in various tumor-promoting pathways, including cancer cell proliferation, invasion, metastasis, epithelial-mesenchymal transition (EMT), angiogenesis, stemness, DNA damage response, acquired therapeutic resistance, immunosuppression, and inflammatory responses. Beyond oncology, AXL also facilitates viral infections, including SARS-CoV-2 and Zika highlighting its importance in both cancer and virology. In preclinical models, small-molecule kinase inhibitors targeting AXL have shown promising anti-tumorigenic potential. This review primarily focuses on the induction, regulation and biological functions of AXL …

Chronic Kidney Disease In Hispanic Population In Us: A Public Health Research Gap, Shyam Chirravoori

Health & Biomedical Sciences Faculty Publications

Hispanic population is very fast growing in the United States of America. The incidence and prevalence of End Stage Renal Disease (ESRD) is Hispanics is higher than that of non-Hispanic Whites. The Hispanics with Chronic Kidney Disease (CKD) are at a greater risk for kidney failure. The main contributing factors for this higher burden of chronic kidney disease are diabetes, and metabolic syndrome. Both diabetes and metabolic syndrome are common in Hispanics. In addition, Health care access, quality of health care, language barrier, health literacy, low socioeconomic status, life style etc., may further contribute to the increased disease burden of …

02.10.2025 Ored Connect, Liz Williamson

ORED Newsletter

Community Engagement Recognition