Medicine and Health Sciences Commons^™

The Effect Of Menstrual Cycle Phase On Igf-1 And Myostatin After An Acute Bout Of Anaerobic Exercise: A Preliminary Analysis, Kelsi R. Lambright, Cayla Clark, Ashley Latchford, Edwin J. Davila, Dan E. Newmire

International Journal of Exercise Science: Conference Proceedings

Hormonal fluctuations throughout the menstrual cycle influence various physiological processes, including skeletal muscle metabolism. Understanding how anabolic and catabolic pathways respond to anaerobic exercise in females is crucial for uncovering the mechanisms behind muscle adaptations. The limited research on the influence of menstrual cycle fluctuations on muscle metabolism underscores the need for this study and further exploration of exercise physiology in females. PURPOSE: The purpose of this study is to investigate the effects of menstrual cycle phases on the anabolic hormone-insulin-like growth factor-1 (IGF-1) and the catabolic regulator myostatin (GDF-8) in response to a bout of anaerobic exercise in eumenorrheic …

Body Composition Impacts Jump Performance In D1 Athletes, Veronika Kramarenko, Vipa Bernhardt, Michael D. Oldham, Brian Jones, Ouays Bakcha, Chaehyun Byun, Cheyenne Martinez, Joseph Mcclain, Marshall Tousant

International Journal of Exercise Science: Conference Proceedings

INTRODUCTION: Body composition is critical in athletic performance, influencing metrics such as jump height and force production. Variations in body composition, such as increased lean tissue mass and reduced fat mass, have been identified as strong predictors of superior jump performance due to their positive effects on power-to-weight ratios and reduced injury risk (MacDonald et al., 2013). Lean mass is strongly correlated with improved jump performance, as greater lean mass enhances muscle cross-sectional area and, consequently, the force and power generated during physical activities like countermovement jumps (CMJ) (Stephenson et al., 2015). Low body fat percentages are generally associated with …

Developing An Evidence-Based Model For Healthy Stride Length Prediction, Jungyu Lee, Ho Han, Heontae Kim, Diego Diaz-Vega

International Journal of Exercise Science: Conference Proceedings

Stride length is a vital health indicator, reflecting physical fitness and mobility status. Although several existing formulas aim to estimate stride length, many are limited by a lack of scientific validation, especially among healthy, active adults. This study addresses these limitations by developing a validated model based on healthy adults without known mobility impairments, aiming to establish a more accurate, clinically useful standard for stride length estimation. The model provides a reference range for healthy stride length, usable as a tool to identify individuals at risk of mobility issues. PURPOSE: To develop an evidence-based model for predicting stride length …

Pre- To Post-Season Changes In Body Composition And Movement Quality And Quantity In D1 Football Players, Brian Jones, Ouays Bakcha, Chaehyun Byun, Veronika Kramarenko, Cheyenne Martinez, Joseph Mcclain, Marshall Tousant, Vipa Bernhardt, Michael D. Oldham

International Journal of Exercise Science: Conference Proceedings

INTRODUCTION: Body composition may influence an individual's movement efficiency and performance outcomes. Lower body fat percentage may enable individuals, either sedentary or athletic, to perform movements more efficiently, while greater total lean mass may enhance performance in strength and power-related activities. PURPOSE: The purpose of this study was to analyze the changes in collegiate football players’ total lean mass and body fat percentage, as well as movement quantity and quality measures from preseason to postseason. METHODS: Data from a larger study were analyzed for this project. Division 1 male football players (n= 72, 19.6 ± 1.4 yrs) …

The Relationship Between Handgrip Strength And Cardiovascular Risk Factors In Older Women, Adriana N. Guerrero, Emily Sauers

International Journal of Exercise Science: Conference Proceedings

Cardiovascular disease is the leading causes of death in the world. Several clinical trials have found that handgrip strength is associated with lower cardiovascular risk and related death. PURPOSE: The purpose of this study was to explore the relationship between cardiovascular risk factors and handgrip strength. METHODS: Subjects for this study included 8 women from the Congregation of Devine Providence (78.13+7.79 yrs) at Our Lady of the Lake University. Preliminary measures included a medical history questionnaire and the CHAMPS physical activity questionnaire. On the first day of testing, subjects arrived fasted between 7-9am. After a 5-minute rest, blood pressure and …

Does Swearing Improve Exercise Performance And Pain Tolerance?: Cultural Perspective, Jide Yinka Adebiyi, Christos Kyrillou, Elijah Martinez, Anika Patel, Emily Payne, Linsheng Chen, Daroonwan Suksom, Hirofumi Tanaka

International Journal of Exercise Science: Conference Proceedings

Swearing is often generated by self or received from others (e.g., coaches) during physical exertion for various reasons including punctuating the passion, releasing frustration, and resetting the mind. However, the effects of swearing and yelling on exercise performance and pain tolerance remain largely unexplored. Additionally, it is unknown whether individuals from different cultures experience varying degrees of impact of yelling and swearing. PURPOSE: We determined the impact of self-generated and observer-generated swearing and yelling on exercise performance and pain tolerance in individuals living in the US where swearing is often used and heard and in Thailand where such occurrence is …

They’Re Faking It! Diagnosing Mtbis Using A Multimodal Approach, Dakota Muth, Priya Choudhary, Giovani Gourial, Cheryl Vanier, Alan Rodriguez, Travis Snyder

Annual Research Symposium

Purpose: Mild traumatic brain injury (mTBI) affects 69 million people annually worldwide. A significant subset of those affected will develop long-term sequelae that can seriously impact quality of life and lead to other health problems. Clinical diagnosis of mTBI is complicated by patient malingering, subjective symptomatology, and variable patient reporting. This review aimed to evaluate the potential effectiveness of combining advanced neuroimaging techniques with psychometric testing and blood biomarker analyses for developing a more objective and comprehensive mTBI assessment protocol.

Methods: A review was conducted using PubMed as the primary database, analyzing studies published between 2015 and 2023. Included studies …

Building Blocks For New Kinship Partnerships And Coalitions, Kathy L. Dial, Daniel J. Koltz, Janet Salo, Erin Beasley

GrandFamilies: The Contemporary Journal of Research, Practice and Policy

Building successful kinship partnerships and coalitions requires intentional effort to establish trust, align goals, and foster inclusivity. These collaborations are essential for addressing the unique and evolving needs of kinship families, who often face limited access to resources due to the informal nature of many caregiving arrangements. Effective partnerships prioritize clear missions, open communication, and active engagement with stakeholders, particularly those with lived experiences such as kinship caregivers. Research demonstrates that coordinated efforts among organizations enhance resource availability, improve advocacy capabilities, and strengthen service delivery. By integrating diversity, equity, and inclusion principles, coalitions can ensure that diverse perspectives shape solutions …

Polmacoxib: A Drug Review, Sakeer Hussain, Dr. Subramanian Ramaswamy , Professor, Mahabaleshwar Mamadapur Assistant Professor, Ananthu Ajikumar

International Journal of Health and Allied Sciences

Polmacoxib, a novel nonsteroidal anti-inflammatory drug (NSAID), has shown a promised therapeutic option for the management of osteoarthritis and other inflammatory conditions. This drug review mainly aims to provide a comprehensive overview of polmacoxib, focusing on its pharmacological properties, clinical efficacy, safety profile, and potential therapeutic applications. Polmacoxib is a notable drug due to its dual mechanism of action, combining selective COX-2 inhibition with inhibition of carbonic anhydrase, which may contribute to its enhanced anti-inflammatory and analgesic effects. Being a selective COX-2 inhibitor, it helps minimize gastrointestinal side effects typically caused by conventional nonselective NSAIDs. Data from clinical studies suggest …

Assessment Of Chronic Kidney Disease Awareness Among Patients In A Tertiary Care Hospital: A Questionnaire- Based Study, Jyothi Basini, Srija Sadanala, Srinivasa Yadav Poolugari, Susmitha Karakambadi, Teja Apthiri, Ram R

International Journal of Health and Allied Sciences

Chronic kidney disease (CKD) is increasingly recognized as a significant global public health concern, influenced by individuals' lifestyle choices. Despite being largely asymptomatic until advanced stages, CKD is associated with heightened risks of cardiovascular disease, premature mortality, and diminished quality of life. Particularly in developing nations like India, where precise prevalence data are scarce, the need for heightened public awareness is paramount. This study, conducted at SVIMS, Tirupati, employed a hospital-based prospective design involving adults (≥18 years) diagnosed with CKD. Through informed consent, participants underwent interviews using structured questionnaires to assess their understanding of CKD. Multivariate logistic regression analysis identified …

2025 February 18 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Perceptions Of Nurse Preceptor Program Structure, Process, And Outcomes, Shinto Thomas

Walden Dissertations and Doctoral Studies

Precepting is crucial in successfully onboarding nurses in healthcare organizations, yet challenges remain in ensuring effective preceptor development. Well-structured preceptor programs contribute to consistent and safe nursing practices, enhance job satisfaction and competency among new nurses, and improve preceptor effectiveness while minimizing turnover. This quality improvement Doctor of Nursing Practice (DNP) project evaluated a structured nurse preceptor program's structure, process, and outcomes, focusing on its impact on clinical and critical thinking skills development through enhanced training and support. A key gap in understanding the program’s effectiveness was the lack of outcome data. This study explored participants’ perceptions of the preceptor …

Safety And Efficacy Of Different Stent Strategies In Percutaneous Coronary Intervention: A Network Meta-Analysis, Waqas Ullah, Harigopal Sandhyavenu, Syeda Ramsha Zaidi, Mileydis Alonso, Muhammad Atif Khan, Irfan Ullah, Farah Yasmin, Aravind Reddy Polam, Salman Zahid, Arnav Kumar, Ewout Steyerberg, Mohammed Murtaza, Chadi Alraiesm, Jeffrey Rade

Jefferson Health - Northeast Papers (formerly Aria Health Papers)

BACKGROUND: The utility of polymer-permanent, polymer-absorbable, and polymer-free drug-eluting stents (DES) in the context of different eluting drugs in patients undergoing percutaneous coronary intervention (PCI) remains controversial.

OBJECTIVES: The purpose of this study was to compare the efficacy of different DES strategies in post-PCI patients.

METHODS: Digital databases were searched to select all randomized control trials. Different combinations of DES were directly compared with permanent-polymer sirolimus-eluting stents. The primary outcome was major adverse cardiovascular events; a composite of cardiovascular mortality, myocardial infarction (MI), and target vessel revascularization. A network meta-analysis was performed to determine the net relative risk (RR) and …

Effect Of Steroids On The Progression Of Alzheimer's Dementia: A Retrospective Chart Review., Julijana Zoran Conic, Alexandra Chetty, Lily Chen, Audrey Marsh, Sean Barry, Rodney Pattabhi, Thomas Reske, Erwin Aguilar, Lobna Ali

School of Medicine Faculty Publications

Objectives: Alzheimer's disease (AD) is a prevalent age‐related neurodegenerative disease that affects millions of individuals in the United States. Neuroinflammation is a driver of the neurodegenerative changes that characterize AD, prompting interest in how inflammation can be modulated for treatment and prevention. Methods: ICD‐10 codes were quarried from electronic medical records to identify patients diagnosed with AD from 2012 to 2020. The patients were then divided into those who used systemic steroids and those who did not before the progression of their disease. Data on medication prescribed was used to measure the disease's progression. Clinical findings and laboratory results were …

Staff Education On Medication Nonadherence For Patients With Bipolar Disorder, Julius Chick Abam

Walden Dissertations and Doctoral Studies

Summary From both the literature and the staff observation in this private practice, bipolar disorder (BD) patients who do not comply with medication are at a higher risk of hospitalization and poor quality of life. The purpose of the project was to implement staff training focused on adherence strategies, including motivational interviewing and psychoeducation to improve medication adherence rates among BD patients. The project question was: Does providing an interactive education program using case studies improve staff knowledge and self-confidence? Different studies support the effectiveness of both psychoeducation and motivational interviewing in improving adherence and functionality in BD. An interprofessional …

Paradigm Shift In Obesity Treatment: An Extensive Review Of Current Pipeline Agents, Ecesu Çeti̇n, Brian Pedersen, Mehmet Furkan Burak

Turkish Journal of Medical Sciences

Obesity is a multifaceted disease that poses a significant public health challenge. Recent discoveries in understanding the biological pathways that regulate satiety and metabolism have led to a shift in the treatment paradigm for obesity. Thus, the gap between pharmacological and surgical interventions has diminished. The latest approved anti-obesity medications are achieving weight loss comparable to surgery. These GLP-1 analog-based therapies not only cause substantial weight loss but also improve obesity-associated comorbidities. However, there are still unmet needs in obesity care, and treatment options with alternative pathways are necessary. Whether achieved through lifestyle changes or medication, weight loss often leads …

Navigating Pregnancy With Cardiovascular Disease: Pathophysiology, Risk Stratification, And Maternal–Fetal Outcomes, Osman Türkmen, Serra Akar İnan

Turkish Journal of Medical Sciences

Pregnancy induces significant cardiovascular changes, including increases in heart rate, blood volume, and cardiac output, which may exacerbate existing heart conditions or unmask previously undiagnosed heart diseases.. This review outlines the types of cardiovascular diseases that affect pregnant women, organized by the modified World Health Organization risk classification. It covers key areas, including how pregnancy impacts the heart, common maternal and fetal complications, and effective management strategies. The review emphasizes the importance of preconception counseling, risk assessment, and continuous monitoring to ensure the best maternal and fetal outcomes. It also highlights practical guidelines for healthcare providers and discusses the latest …

Antifungal Prophylaxis In High-Risk Patients With Hematologic Malignancy:A Comparison Of Practice With Guidelines In Türkiye, Özlem Güzel Tunçcan, Seçki̇n Çağirgan, Hakan Özdoğu, Si̇nem Ci̇vri̇z Bozdağ, Fi̇li̇z Vural, Mustafa Pehli̇van, Hüseyi̇n Saffet Beköz, Yasemi̇n Esen, Tuba Koç, Petek Gi̇li̇k, Esi̇n Şenol

Turkish Journal of Medical Sciences

Background/aim: Primary antifungal prophylaxis (AFP) is recommended by guidelines as the gold standard for patients with hematologic malignancies. This study aimed to investigate the level of knowledge and translation of guideline recommendations into real-life setting among physicians in Türkiye.Materials and methods: In this prospective, observational study, the physicians’ knowledge of ΑFP guideline recommendations in patients with acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) undergoing first remission-induction (Group I), and graft-versus-host-disease (GvHD) after allogeneic stem cell transplant (Group II), was compared with clinical practice via 11-item multiple-choice questionnaire evaluating the timing and patients in whom AFP was initiated, with AFP …

Thoracic Disc Herniations: Diagnosis, Surgical Techniques, And Complication Insights, Mehmet Deni̇zhan Yurtluk, Aydin Si̇nan Apaydin, Hakan Kina, Khoi Than

Turkish Journal of Medical Sciences

Abstract: Thoracic disc herniations (TDHs) are rare conditions, comprising 0.1% to 5% of all reported herniation cases, and affecting up to 1 in 1,000,000 individuals. The mid to lower thoracic spine, particularly between the T11 and T12 vertebrae, is most frequently affected and often associated with trauma. Conditions like Scheuermann’s disease can predispose patients to TDHs. This study explores the clinical manifestations, diagnostic methods, surgical techniques, and complications associated with TDHs. Diagnosis relies on magnetic resonance imaging and computed tomography myelography to identify the level and nature of the herniation. Various surgical approaches, including posterolateral, lateral, and anterior, have been …

Synthetic Osteobiologics In Spine Surgery: A Review, Aydin Si̇nan Apaydin, Eli Johnson, Prince Antwi, Brett Rocos, Michael M. Haglund, Christopher Shaffrey, Peter Passias, Muhammad Adb-El-Barr, Khoi Than

Turkish Journal of Medical Sciences

Background/aimOsteobiologics are increasingly used in orthopedics and spine surgery to facilitate bone healing and prevent non-union. Synthetic osteobiologics are artificial materials crafted in laboratories that aim to replicate the natural composition and functionality of bone. Notable examples, such as calcium phosphate and calcium sulfate, are engineered to mirror the mineral aspect of bone. They mimic human bone functionality, exhibiting osteoconductive, osteoinductive, and osteogenic properties. These characteristics promote cell attachment, migration, recruitment, and differentiation. Consequently, synthetic osteobiologics (osteoconductive grafts) have been introduced in bone fracture repair. The main strength of synthetic osteobiologics in spine surgery lies in improving fusion rates and …

Genetic Mutations And Prognostic Indicators In Differentiated Thyroid Cancer: A Molecular Perspective, Hali̇m Özçevi̇k, Müge Öner Tamam, Gündüzalp Buğrahan Babacan, Selma Şengi̇z Erhan, Merve Nur Acar Tayyar, Bi̇ray Ertürk

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the relationship between the presence of BRAF, HRAS, NRAS, and KRAS gene mutations and the development of dedifferentiation (iodine-refractory disease) and extrathyroidal disease in patients with differentiated thyroid carcinoma (DTC).Materials and methods: Seventy-seven adult patients classified as intermediate and high-risk according to the ATA 2015 guidelines, who underwent total thyroidectomy followed by radioiodine I-131(RAI) therapy between June 2014 and December 2022, were included. Clinical data were collected via the hospital information system, including the number of surgeries, RAI treatments, and levels of thyroglobulin(Tg), anti-thyroglobulin, and thyroid-stimulating hormone. Histopathological subtypes of DTC were re-evaluated, and …

Empagliflozin Effects On Cyclophosphamide-Induced Neurotoxicity In Rats Without Diabetes, Şeri̇fe Ezgi̇ Doğan, Şeri̇fe Mehli̇ka Kuşkonmaz, Pinar Celepli̇, Mehmet Şenes, Sema Hücümenoğlu, Cavi̇t Çulha

Turkish Journal of Medical Sciences

Background/aim: The objective of this study is to evaluate the effect of empagliflozin on cyclophosphamide-induced neurotoxicity in rats.Materials and methods: A total of 32 male Wistar rats were separated into 4 groups as 8 rats each: control group, cyclophosphamide group, empagliflozin group and the cyclophosphamide plus empagliflozin group. At the end of the experiment rats' brains were removed for biochemical analysis of oxidative stress parameters (malondialdehyde, total sulfhydryl, total oxidant status and total antioxidant capacity) and histopathological analysis.Results: Total sulfhydryl levels were increased in group empagliflozin and group empagliflozin and cyclophosphamide compared to the cyclophosphamide group but did not improve …

Impact Of Concurrent Parathyroid Adenoma On The Recurrence Of Differentiated Thyroid Carcinoma: A Retrospective Study, Derya Çayir, Alev Çinar, Mehmet Bozkurt, Bahadir Külah

Turkish Journal of Medical Sciences

Background/aim: The impact of concurrent parathyroid adenoma in differentiated thyroid carcinoma remains unclear. This study was performed to compare the recurrence rates of patients operated on for differentiated thyroid carcinoma with concomitant parathyroid adenoma and those operated on for thyroid carcinoma without detected parathyroid adenoma.Materials and methods: This retrospective study examined 340 patients who underwent total thyroidectomy for thyroid carcinoma at our institution. We compared the patients with concurrent parathyroid adenoma to those without, assessing clinical, laboratory, surgical, and histopathological findings and thyroid carcinoma recurrence over a 6-year postoperative period.Results: Among all patients, 53/340 (16%) were identified with parathyroid adenoma, …

New Index For Distinguishing Between Critical Illness Myopathy And Neuromyopathy: Cmap Amplitude/Duration Index, Handan Uzunçakmak Uyanik, Fatma Gökçem Yildiz, Çağri Mesut Temuçi̇n

Turkish Journal of Medical Sciences

Background/Aim: Critical illness-associated weakness (CIAW) is a common neuromuscular syndrome that may manifest as critical illness myopathy (CIM), critical illness polyneuropathy (CIP), or an overlap syndrome known as critical illness polyneuromyopathy (CIPM). Distinguishing between these subtypes can be challenging due to technical issues, patient-related factors such as insufficient cooperation with needle electromyography (EMG) and edema, and the need for sophisticated, time-consuming electrophysiological methods and invasive procedures such as biopsy. This study aims to contribute to the electrophysiological distinction between CIM and CIPM. Materials and methods: A new index was calculated based on distal compound muscle action potential (CMAP) amplitude and …

The Use Of Antiepileptic Drugs And Their Effects In Pregnancy, Pinar Öztürk, Ali̇ Turhan Çağlar

Turkish Journal of Medical Sciences

Background/Aim: Epilepsy is one of the most common chronic neurological diseases. Epilepsy can affect the entire life, including childbearing age. It is estimated that epileptic women give three to five births per thousand births. Although the use of antiepileptic drugs (AEDs) during pregnancy has been associated with major congenital malformations in the fetus, many patients cannot discontinue the drugs before pregnancy due to the risk of seizures that may harm the mother as well as the children. In this study, our aim is to examine the follow-up findings of pregnant women who are epileptic and use AEDs during pregnancy and …

Evaluation Of Nonmotor Symptoms In Myasthenia Gravis Patients, Aysel Tekeşi̇n, Çağla Şi̇şman, Ufuk Emre Toprak, Alena Sar, Burcu Akalin, Goncagül Koşargeli̇r, Meli̇h Tütüncü, Enes Yi̇ği̇t

Turkish Journal of Medical Sciences

Background/aim: Myasthenia gravis (MG) is chronic autoimmune disorder characterized primarily by muscle weakness and fatigue, due to autoantibodies targeting acetylcholine receptor at neuromuscular junction. In this study, we aimed to evaluate non-motor symptoms in myasthenia gravis patients and compare them with disease duration, severity and clinical features.Materials and methods: This prospective study was conducted with thirty-five myasthenia gravis patients and thirty-five healthy volunteers. Total of 35 patients, 17 women and 18 men with mean age of 52.9±13.6 years constituted patient group. Control group consisted of total of 35 participants, 23 women and 12 men with mean age of 46.9±12.2 years. …

Novel Nonmagnetic Abutment Designs For Facial Prostheses: An Experimental Study, İrem Sozen Yani̇k, Ufuk Adali̇, Jamila Yassine, Fransizka Schmidt, Wolfgang Hannak, Bahadir Ersu

Turkish Journal of Medical Sciences

Background/aim: This in vitro study aimed to evaluate and compare the retentive forces of novel nonmagnetic abutment designs developed as an alternative to conventional magnetic abutments for facial prostheses.Materials and methods: A plexiglass model was constructed and two extraoral implants were placed in these blocks in a parallel position. Nonmagnetic abutments made of titanium were fabricated and screwed onto the implants. The nonmagnetic systems represent a novel design and include two different abutment designs (Type 1 and Type 2) with silicone attachments. Retentive force values for three abutment types: Conventional Magnetic System (CMS), Nonmagnetic abutment Type 1 System (NMS1), and …

Duple-Mondnet: Duple Deep Learning-Based Mobile Net For Motor Neuron Disease Identification, Sony Helen, Joseph Jawhar

Turkish Journal of Medical Sciences

Background/aim: Motor neuron disease (MND) is a devastating neuron ailment that affects the motor neurons that regulate muscular voluntary actions. It is a rare disorder that gradually destroys aspects of neurological function. In general, MND arises as a result of a combination of natural, behavioral, and genetic influences. However, early detection of MND is a challenging task and manual identification is time-consuming. To overcome this, a novel deep learning-based duple feature extraction framework is proposed for the early detection of MND.Materials and methods: Diffusion tensor imaging tractography (DTI) images were initially analyzed for color and textural features using dual feature …

Integrated Convolutional Neural Network For Skin Cancer Classification With Hair And Noise Restoration, Ni̇dhi̇ Bansal, Sri̇dhar Sundaramurthy

Turkish Journal of Medical Sciences

Background/aim: Skin lesions are commonly diagnosed and classified using dermoscopic images. There are many artifacts visible in dermoscopic images, including hair strands, noise, bubbles, blood vessels, poor illumination, and moles. These artifacts can obscure crucial information about lesions, which limits the ability to diagnose lesions automatically. This study investigated how hair and noise artifacts in lesion images affect classifier performance and how they can be removed to improve diagnostic accuracy.Materials and methods: A synthetic dataset created using hair simulation and noise simulation was used in conjunction with the HAM10000 benchmark dataset. Moreover, integrated convolutional neural networks (CNNs) were proposed for …

A New Approach In The Treatment Of Ultrasound-Guided Synovial Hypertrophy, Emel Güler, Alper Doğanci

Turkish Journal of Medical Sciences

Background/aimKnee osteoarthritis (OA) causes pain, limited movement, and negatively impacts daily life in older adults. Hypertrophy and changes in the synovial tissue significantly contribute to the pain. While intra-articular injections are common in OA treatment, specific therapies for hypertrophic tissue are rarely mentioned. This study aims to evaluate the long-term outcomes of local anesthetic and steroid injections in the knee's intra-articular space and hypertrophic synovial tissue.Materials and methodsOur retrospective study included patients with grade 3-4 kne OA diagnosed with ultrasound-guided suprapatellar effusion and synovial hypertrophy. Pain was assessed using the Numerical Rating Pain Scale (NRS), and functional capacity was evaluated …