Medicine and Health Sciences Commons^™

Problems In The Insulin Dependent Diabetic, Clay T. Gardner Jr.

MCV/Q, Medical College of Virginia Quarterly

It is often useful for the physician to classify diabetes as stable or unstable. Maturity-onset diabetes is usually stable, and its management is not difficult, provided the patient is interested and cooperative. Tendency to obesity, relative insensitivity to insulin, and absence of ketosis are characteristic of such patients. Relative insensitivity to insulin does not imply unresponsiveness, but rather that the blood sugar is not overly labile and does not fall sharply in response to exercise or injected insulin. Many patients with such insensitivity to insulin are adequately managed on diet, alone or in combination with the oral hypoglycemic agents. When …

The Natural History Of Diabetic Retinopathy, Guy H. Chan

MCV/Q, Medical College of Virginia Quarterly

Diabetic retinopathy is a common and increasing cause of blindness. The higher incidence of retinopathy is related to the longer survival of the diabetic patient. The etiology of diabetic retinopathy remains unknown. However, two varieties appear to exist: Type I retinopathy, characterized by a slowly progressive course and ophthalmoscopic findings of microaneurysms, round hemorrhages, and waxy exudates; and Type II retinopathy, associated with a more rapid loss of vision, in which the main findings are venous engorgement, vascular proliferation, connective tissue condensation, and recurrent vitreous hemorrhages. Both types may result in retinitis proliferans and blindness. In the proliferative (Type II) …

Rate Of Diffusion Of Radioactive Ions In Gels, Thomas C. Smith, Addison D. Campbell, Ernst G. Huf

MCV/Q, Medical College of Virginia Quarterly

A simple gel-to-gel method is described for the estimation of diffusion coefficients (D) of radio-isotopic chemicals. "Cold" and "hot" gel cylinders, enclosed in small hypodermic syringes with their needle ends cut off, were carefully joined together, and diffusion was allowed to proceed for several hours. Slices of gels were then obtained for counting of activities. Application of the classical theory of diffusion permitted calculations of D values.

Inappropriate Antidiuresis: Examples Of An Hyponatremic Syndrome Resembling Exogenous Vasopressin Administration In Man, Eugene L. Klingler, Joseph H. Magee, John D. Bower, Richard H. Kirkland, Ruben G. Lancestremere

MCV/Q, Medical College of Virginia Quarterly

We have reviewed some of the features of hyponatremic syndromes, unassociated with sodium retention and edema, but associated with primary water retention. The syndromes were probably caused by excessive vasopressin activity, in the presence of normal circulatory, renal and adreno-cortical function. Underlying diseases, including bronchogenic carcinoma, head injury, and tuberculous meningitis, illustrated the diverse etiologic bases of this condition.

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 2 No. 1

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

Contrangle - Vol. 7, No. 5, Dental Students Association

Contrangle

In this issue:

- Dean''s Honor Roll - A High Standard of Achievement

- Editorial

- DSA - - Jan. 13

- Loma Linda Sponsors Dental Student Research

- What, Me Specialize? Specialization in Periodontology

- Hygienist News

- Freshmen Hear Dean Sognnaes

- Alumni News . . .

- Space Fillers!

- S.S. White

Training Workout Log Book 1957-1966, Edward S. Temple

Temple Training Workout Log Books

No abstract provided.

Diabetic Neuropathy, Max Ellenberg

MCV/Q, Medical College of Virginia Quarterly

Diabetic neuropathy is becoming increasingly recognized because of its frequency and the severity of its manifestations. There is no domain in the field of medicine or surgery that is not at some time concerned with diabetic neuropathy. Neuropathy in diabetes may be divided into somatic and visceral types. I will discuss chiefly visceral neuropathy, but I should first say a few words about somatic neuropathy, which is the commoner of the two.

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, Summer 1966, Volume Two, Number Two.

Self-Diffusion In Sodium Single Crystals, Rama M. Aiyawar, Addison D. Campbell

MCV/Q, Medical College of Virginia Quarterly

The objective of this investigation was the study of self-diffusion in single-crystal sodium using tracer techniques and the determination of the diffusion constant and activation energy. Precise values of these quantities can be obtained by using Fick's second law of diffusion and the relation D = D₀ exp (- Q/RT) provided the concentration of the diffusing isotope is kept very small. However, in the above relation, the quanties D₀ (diffusion constant) and Q (activation energy) may vary with the composition of the crystal and with impurity content but are independent of temperature.

Volume One Table Of Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, Volume One.

The Changing Pattern Of General Practice And Its Educational Implications, Frederick J. Spencer

MCV/Q, Medical College of Virginia Quarterly

The results of a mail questionnaire sent to members of the Virginia Academy of General Practice demonstrate the changes occurring in the content of family practice. Practitioners in small towns practice more obstetrics and less internal medicine than those in large cities, and conversely. The implications for training in general practice are discussed.

Some Surgical Problems In Diabetic Patients, David M. Hume

MCV/Q, Medical College of Virginia Quarterly

These patients illustrate some of the more perplexing and challenging surgical problems in diabetic patients. There are many others, but these are particularly gratifying because only a few years back the circulatory problems in the lower extremities were treatable only by high amputation, and in the case of kidney disease with renal failure, there was no other treatment at all.

Contributors

MCV/Q, Medical College of Virginia Quarterly

List of contributors to this issue includes Edward N. Brandt, Jr., Jay Goldman, Harold I. Nemuth, and Herbert Wiesinger.

Contributors

MCV/Q, Medical College of Virginia Quarterly

List of contributors to this issue includes Marvin J. Allison, John D. Bower, Jack D. Burke, Alistair Cooke, Joseph T. Doyle, Enrique Gerszten, Carl Goldsmith, Thomas M. Harris, Robert J. Huebner, S. James Kilpatrick, Jr., Richard H. Kirkland, Eugene L. Klingler, Jr., Ruben G. Lancestremere, Joseph H. Magee, Kenneth Mullen, and Blanca Secades Sanchez.

A Tissue Culture Perfusion Chamber With A Substratum Of Reconstituted Collagen, Thomas M. Harris

MCV/Q, Medical College of Virginia Quarterly

A tissue culture chamber is described that introduces the concept of a fixed platform within a "perfusion type" chamber. The platform is made of stainless steel mesh covered with a membrane of reconstituted collagen. The collagen membrane serves as the supporting substratum for the cultured tissue and is of such an optical quality as to permit phase-contrast microscopic observation of the tissue. The perfusion chamber is a Sykes-Moore tissue culture chamber modified to twice its normal depth to receive the screen. Cell growth in the experimental chamber is superior to growth in the control chamber both in speed of proliferation …

Brains Of Prominent People: History, Facts And Significance, Walther Riese

MCV/Q, Medical College of Virginia Quarterly

In conclusion, in the brains of outstanding right-handed people (Haeckel, Monakow, Pilsudski) the more complicated convolutional and fissural patterns were found on the left hemisphere; in those of outstanding left-handed people (Menzel, Edinger) on the right one. The second brain reported here revealed some overdevelopments on the right, others on the left hemisphere. Strangely enough, very little is known about side-differences in the average brain. It seems that the middle frontal convolution and the inferior parietal lobe are more developed on the right hemisphere, the inferior frontal convolution on the left one. Nothing is known about the handedness of the …

The Management Of Diabetes In Children, Thaddeus S. Danowski

MCV/Q, Medical College of Virginia Quarterly

I think the time will come when we will all agree that diabetes mellitus is indeed the most common endocrinopathy, and that if we live long enough, at least 25% of the people in this room will develop diabetes. I believe that diabetes has manifestations both as a homozygous and heterozygous state, and that the heterozygous state or so-called carrier state become clinically manifest as we get older. Now I am not sure that such diabetes has the same significance as diabetes coming on earlier in life. It may be a benign type of diabetes, but at any rate, it …

A Deadly Poison Becomes A Useful Tool, John W. Moore

MCV/Q, Medical College of Virginia Quarterly

The very high potency of TTX and its highly selective block of nerve and skeletal muscle fibers has already shed a great deal of light on their excitation properties and should lead to the ability to specify an entirely new type of anesthetic agent even if the toxin itself does not also turn out to be useful agent in this respect.

Ambulatory Services In Teaching Hospitals, Gabriel Hilkovitz

MCV/Q, Medical College of Virginia Quarterly

The outpatient clinics and emergency rooms of metropolitan teaching hospitals have been criticized severely in recent years for providing poor patient care. In most teaching hospitals the ratio between outpatients and inpatients is three to one; therefore, if the critics are right, 75% of the patients who obtain medical care at the teaching hospital, are not getting the best that medicine has to offer today.

A Ranking Test In The Biological Sciences, Kenneth Mullen

MCV/Q, Medical College of Virginia Quarterly

Laboratory analyses of biological materials are ranked in order of magnitude and summed across materials to give a list of laboratory scores. Under the assumed hypothesis that there is in fact no difference between laboratories, Monte-Carlo techniques are used to establish two-tailed 5% rejection limits for various combinations of laboratories and materials. The hypothesis that there is no difference between laboratories is rejected if any laboratory's score lies outside the 5% limits. Suppose that one needs to run a group of tests on a particular set of materials (chemical or biological), using a number of different laboratories, and wishes to …

Volume Two Table Of Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, Volume Two.

Clinicopathological Conference: Painful Leg Mass In A 23-Year-Old Male, Gerald A. Gildersleeve, Saul Kay

MCV/Q, Medical College of Virginia Quarterly

Report based on a clinicopathlogical conference transcript from the Medical College of Virginia regarding a painful leg mass in a 23 year-old male. Discussants include Gerald A. Gildersleeve and Saul Kay.

Applications Of Computers To Medicine, Edward N. Brandt Jr.

MCV/Q, Medical College of Virginia Quarterly

The purpose of this paper is to present an over-view of current applications of computers to problems in medicine and not to discuss any specific application in detail. This discussion will be concerned only with digital computers. The modern digital computer is not very old. As a matter of fact, digital computers as we know them date from approximately 1949. Yet in this short span of time they have contributed to almost every sphere of man's activities. Computers have been applied to medical problems since about 1956, and have played an important role in increasing both the depth and breadth …

A Simple Rapid Method For Determining Oxyhemoglobin Affinity: Illustration Using Blood From The Rhesus Monkey, Jack D. Burke

MCV/Q, Medical College of Virginia Quarterly

Blood was obtained by cardiac puncture from the Rhesus monkey (Macaca mulatta). Hemolysates were prepared by filtration and centrifugation at 20,000 X g at 4 C. Oxyhemoglobin affinity curves were determined by a simplified spectrophotometric procedure on hemolysates diluted with phosphate buffers at pH of 7.4 and 6.8, and at an ionic strength of 0.3. The spectrophotometric readings were made at a wavelength of 640mμ and at a temperature of 23 C. The oxygen pressure at one-half saturation (P₅₀) for Rhesus homoglobin at a pH of 7.4 was 15 mm Hg, and at the more acid pH of 6.8, 23 …

Diabetic Glomerulosclerosis, J. M. B. Bloodworth Jr.

MCV/Q, Medical College of Virginia Quarterly

Why should the mesangial cells be irritated? We recently observed in some diabetics black deposits beneath and on both sides of the basement membrane. These appear quite similar to deposits seen in and around the basement membrane in glomerulonephritis and in lupus nephritis. I do not know for sure what they are, but theory says that in glomerulonephritis they probably represent antigen-antibody complexes. There is some evidence to support this. One would assume that in diabetes they might be the same thing. Or they might be some other atypical plasma protein which results from the abnormal pattern of diabetic metabolism. …

Treatment Of Diabetes With Oral Hypoglycemic Drugs, James M. Moss

MCV/Q, Medical College of Virginia Quarterly

Oral hypoglycemic drugs now available are of two types. The biguanides, of which phenformin (DBI) is the only one available, increase glucose utilization by muscles. The sulfonylureas, tolbutamide (Orinase), acetohexamide (Dymelor), and chlorpropamide (Diabinese), stimulate the pancreas to produce and release more insulin. All three sulfonylureas have the same effect in responsive patients, but they differ in potency and in duration of action.

Volume Two Subject Index

MCV/Q, Medical College of Virginia Quarterly

Subject index for MCV/Q, Medical College of Virginia Quarterly, Volume Two.

The Healing Of Persons, Paul Tournier

MCV/Q, Medical College of Virginia Quarterly

Text of a talk delivered, in French, by Paul Tournier, at the Medical College of Virginia, April 27, 1965. Translation by Miss Beryl Eeman.

The Shame Of American Medicine, Elinor Langer

MCV/Q, Medical College of Virginia Quarterly

The success of American medicine is often attributed to the profession's ability to serve the public on its own terms. Why should doctors care if, from the patient's point of view, the terms chosen--solo practice and emphasis on the "doctor-patient relationship"--mean that a doctor performs unsupervised services for unregulated fees? What does it matter to them that the poor are outside the system altogether, treated in charity wards or public hospitals which are the medical equivalent of Andrew Carnegie's libraries, a small concession to charity from an accelerating machine of wealth, power, and influence? In a country proud of its …