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Articles 3151 - 3180 of 326363

Full-Text Articles in Medicine and Health Sciences

Early-Stage Corticostriatal Hyperactivity Impairs Cognitive Flexibility Alongside Striatal Cholinergic Dysfunction In An Alzheimer's Disease Model, Yufei Huang, Xueyi Xie, Zhenbo Huang, Ruifeng Chen, Himanshu Gangal, Xuehua Wang, Karienn Souza, Julia Hunter, Xin Wu, Doodipala Samba Reddy, Jeannie Chin, Jun Wang Jun 2026

Early-Stage Corticostriatal Hyperactivity Impairs Cognitive Flexibility Alongside Striatal Cholinergic Dysfunction In An Alzheimer's Disease Model, Yufei Huang, Xueyi Xie, Zhenbo Huang, Ruifeng Chen, Himanshu Gangal, Xuehua Wang, Karienn Souza, Julia Hunter, Xin Wu, Doodipala Samba Reddy, Jeannie Chin, Jun Wang

Faculty, Staff and Students Publications

Cognitive flexibility declines early in Alzheimer's disease, yet the underlying circuit mechanisms remain unknown. Here, we report that young 5xFAD mice exhibit deficits in instrumental reversal learning prior to spatial memory impairment. This behavioral inflexibility is associated with abnormal neuronal reactivation in the medial prefrontal cortex and dorsomedial striatum. Electrophysiological recordings reveal that medial prefrontal cortex neurons are hyperexcitable and receive increased excitatory input. Furthermore, glutamatergic transmission from the medial prefrontal cortex to striatal direct-pathway medium spiny neurons is enhanced and coincides with strengthened inhibitory transmission onto striatal cholinergic interneurons, reduced spontaneous firing, and diminished striatal acetylcholine release. Critically, sustained …

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Assessing Clinician Preference For Redirection Of Care In Neonatal Tracheostomies, Gabriella Destefano, Alla Kushnir, Perri Donenfeld Jun 2026

Assessing Clinician Preference For Redirection Of Care In Neonatal Tracheostomies, Gabriella Destefano, Alla Kushnir, Perri Donenfeld

Cooper Rowan Medical Journal

A spectrum of indications exists for the implementation of neonatal tracheostomies, ranging from short-term airway control to congenital airway anomalies. The decision to initiate long-term mechanical ventilation is multifaceted and can be influenced by factors such as physician preferences, caregivers’ attitudes, and comorbidities. It is important to have an ethical framework in place to guide the treatment of preterm neonates who may require long term mechanical ventilation. This study examines physician perspectives on the ethics of neonatal tracheostomy, focusing on the treatment of infants with bronchopulmonary dysplasia. A mixed methods study, consisting of demographic information and 5 clinical vignettes centering …

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Plasma Gdf15 Affects Long-Term Dementia Risk And Alters Neuroimmune Signaling, Cassandra O Blew, Michael R Duggan, Dimitrios Tsitsipatis, Gabriela T Gomez, Zulema Rodriguez-Hernandez, Luke C Pilling, Jingsha Chen, Eva Jacobsen, Heather E Dark, Yifei Lu, Shannon M Drouin, Cassandra M Joynes, Minhao Yao, Murat Bilgel, Abhay Moghekar, Qu Tian, Julián Candia, Mary Kaileh, Aditi Gupta, Krystyna Mazan-Mamczarz, Myriam Gorospe, Alexey Lyashkov, Yevgeniya Lukyanenko, Mika Kivimaki, Philipp Frank, Lori L Jennings, Valborg Gudmundsdottir, Vilmundur Gudnason, Lenore J Launer, Naoto Kaneko, Shintaro Kato, Makio Furuichi, Masaki Shibayama, Masahisa Katsuno, Keita Hiraga, Yukiko Nishita, Rei Otsuka, James R Pike, Mary R Rooney, Pascal Schlosser, Yuhan Cui, Guray Erus, Christos Davatzikos, Rebecca F Gottesman, Iwao Waga, Priya Palta, Christie Ballantyne, Michael Griswold, Zhonghua Liu, Luigi Ferrucci, Allison B Herman, Keenan A Walker Jun 2026

Plasma Gdf15 Affects Long-Term Dementia Risk And Alters Neuroimmune Signaling, Cassandra O Blew, Michael R Duggan, Dimitrios Tsitsipatis, Gabriela T Gomez, Zulema Rodriguez-Hernandez, Luke C Pilling, Jingsha Chen, Eva Jacobsen, Heather E Dark, Yifei Lu, Shannon M Drouin, Cassandra M Joynes, Minhao Yao, Murat Bilgel, Abhay Moghekar, Qu Tian, Julián Candia, Mary Kaileh, Aditi Gupta, Krystyna Mazan-Mamczarz, Myriam Gorospe, Alexey Lyashkov, Yevgeniya Lukyanenko, Mika Kivimaki, Philipp Frank, Lori L Jennings, Valborg Gudmundsdottir, Vilmundur Gudnason, Lenore J Launer, Naoto Kaneko, Shintaro Kato, Makio Furuichi, Masaki Shibayama, Masahisa Katsuno, Keita Hiraga, Yukiko Nishita, Rei Otsuka, James R Pike, Mary R Rooney, Pascal Schlosser, Yuhan Cui, Guray Erus, Christos Davatzikos, Rebecca F Gottesman, Iwao Waga, Priya Palta, Christie Ballantyne, Michael Griswold, Zhonghua Liu, Luigi Ferrucci, Allison B Herman, Keenan A Walker

Faculty, Staff and Students Publications

Growth/differentiation factor-15 (GDF15) is a secreted cytokine strongly associated with dementia risk. However, the extent to which GDF15 represents a biomarker and driver of dementia risk remains unclear. Across multiple cohorts, we demonstrated that plasma GDF15 is associated with greater dementia risk over 15- to 25-year follow-up periods when measured in midlife, with stronger associations observed for vascular, compared to Alzheimer's disease (AD), dementia. Two-sample Mendelian randomization supported plasma GDF15's mechanistic role in AD and related dementias, while cohort studies linked it to cerebral small vessel disease, neurodegeneration, phosphorylated tau, and a cerebrospinal fluid proteomic signature indicative of neuroimmune activation. …

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Human Milk Small Extracellular Vesicles Elicit Changes In Inflammatory Response In Infant Human Intestinal Enteroids, Kacie D Waiters, Anthony S Peidl, Hailey A Mcandrew, Ashfia F Khan, Grace Adeniyi-Ipadeola, Hephzibah Nwanosike, Sana Sharif, M Funmi Babajide, Micah Castillo, Preethi H Gunaratne, Samaneh Karami, Hoa Nguyen-Phuc, Xinli Liu, Sasirekha Ramani, Tasneem Bawa-Khalfe Jun 2026

Human Milk Small Extracellular Vesicles Elicit Changes In Inflammatory Response In Infant Human Intestinal Enteroids, Kacie D Waiters, Anthony S Peidl, Hailey A Mcandrew, Ashfia F Khan, Grace Adeniyi-Ipadeola, Hephzibah Nwanosike, Sana Sharif, M Funmi Babajide, Micah Castillo, Preethi H Gunaratne, Samaneh Karami, Hoa Nguyen-Phuc, Xinli Liu, Sasirekha Ramani, Tasneem Bawa-Khalfe

Faculty, Staff and Students Publications

Human milk (HM) is the key nutritional source for infants and the most effective preventative approach against serious gastrointestinal inflammatory diseases like necrotizing enterocolitis (NEC) in preterm infants. Numerous studies in animal models indicate HM-derived small extracellular vesicles (HMEV) reduce severity of inflammation; however, data on human-specific models are limited. Isolated HMEV were characterized from early-HM (colostrum and transitional), mature-HM, and a combined, pasteurized donor bank-like HM sample (pool-); pool-HMEV retains a profile aligned with HMEV from both early- and mature-HM samples. Exposure to pool-HMEV initiates unique gene signatures associated with reduction of inflammation including NFkB-driven TNFα signaling in human …

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Instructions To Authors, Academy Editors Jun 2026

Instructions To Authors, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

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Journal Acknowledgements And Editorial Board, Academy Editors Jun 2026

Journal Acknowledgements And Editorial Board, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

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Keynote Address And Meeting Program, Academy Editors Jun 2026

Keynote Address And Meeting Program, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

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Business Meeting Report (Secretary's And Treasurer's Report), Academy Editors Jun 2026

Business Meeting Report (Secretary's And Treasurer's Report), Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

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Artificial Food Colors Are Not Needed To Attract Ruby-Throated Hummingbirds (Archilochus Colubris) To Feeders, A. Siddiqui, R. Kannan Jun 2026

Artificial Food Colors Are Not Needed To Attract Ruby-Throated Hummingbirds (Archilochus Colubris) To Feeders, A. Siddiqui, R. Kannan

Journal of the Arkansas Academy of Science

No abstract provided.

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Sperm Morphology In The Eastern Narrow-Mouthed Frog, Gastrophryne Carolinensis (Anura: Microhylidae), S. E. Trauth Jun 2026

Sperm Morphology In The Eastern Narrow-Mouthed Frog, Gastrophryne Carolinensis (Anura: Microhylidae), S. E. Trauth

Journal of the Arkansas Academy of Science

Studies by Scheltinga et al. (2002) and Scheltinga and Jamieson (2003) provide the most comprehensive analysis and only review of sperm morphology in Narrow-Mouthed Frogs (family Microhylidae). Of the 490+ species known to occur in this anuran family (Vitt and Caldwell 2014), only 3 are distributed in the United States (Powell et al. 2016), and 2 of these occur in Arkansas (Trauth et al. 2004). Surprisingly, sperm studies on only 12 microhylid species have been conducted (Scheltinga and Jamieson 2003), and no sperm studies are available on any North American species.

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Multiple Nuclear Configurations And Microtubular Arrangements In Spermatozoa Of The Western Siren, Siren Nettingi (Caudata: Sirenidae), S. E. Trauth Jun 2026

Multiple Nuclear Configurations And Microtubular Arrangements In Spermatozoa Of The Western Siren, Siren Nettingi (Caudata: Sirenidae), S. E. Trauth

Journal of the Arkansas Academy of Science

I examined the ultrastructure of spermatozoa of the Western Siren, Siren nettingi, using transmission electron microscopy. My primary objective in this study was to elucidate, for the first time, the unique morphological complexity of biflagellated sperm in this species. This study also represents my fifth addition in a series of investigations that highlight the novel nature of all aspects of spermatogenesis in this salamander I show the basic sperm transverse and sagittal design which includes a nucleus, 2 axial fibers supporting 2 undulating membranes which have 2 axonemes residing at their terminal ends, several circular mitochondria, and several electron-dense masses. …

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Binucleation And Seasonal Cycle Of Sertoli Cells In The Western Lesser Siren, Siren Nettingi (Caudata: Sirenidae), S. E. Trauth Jun 2026

Binucleation And Seasonal Cycle Of Sertoli Cells In The Western Lesser Siren, Siren Nettingi (Caudata: Sirenidae), S. E. Trauth

Journal of the Arkansas Academy of Science

I examined binucleation and the seasonal cycle of Sertoli cells in the Western Siren (Siren nettingi) using light microscopy and transmission electron microscopy. My primary objective in this study was to report, for the first time, the presence of double nuclei in Sertoli cells in a salamander. This study also represents the sixth contribution in a series of investigations that highlight the novel nature of all aspects of spermatogenesis in this unique salamander. My findings add to a growing list of extraordinary morphological and reproductive features that distinguish this salamander from all other vertebrates.

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Distal Urogenital Anatomy And Epithelial Morphology In The Male Eastern Narrow-Mouthed Frog, Gastrophryne Carolinensis (Anura: Microhylidae), S. E. Trauth Jun 2026

Distal Urogenital Anatomy And Epithelial Morphology In The Male Eastern Narrow-Mouthed Frog, Gastrophryne Carolinensis (Anura: Microhylidae), S. E. Trauth

Journal of the Arkansas Academy of Science

I investigated the microanatomy of the distal urogenital system in male Eastern Narrow-Mouthed Frogs (Gastrophryne carolinensis) from a small sample (n = 5) collected in central Arkansas in April, May, and July (2021) and May 2022. Specifically, my primary goals were to elucidate the histology of the following: (1) the paired Wolffian (urogenital) ducts caudally from the kidneys to their merging with the urodeum of the cloaca, (2) the structure of seminal vesicles, and (3) the epithelial morphologies among the distal urogenital tract, the posterior alimentary canal, and the cloaca. My histological analysis confirmed the presence of …

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Academy Presidents And Institutional Members, Academy Editors Jun 2026

Academy Presidents And Institutional Members, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

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Table Of Contents, Academy Editors Jun 2026

Table Of Contents, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

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Journal Of The Arkansas Academy Of Science Volume 79, Academy Editors Jun 2026

Journal Of The Arkansas Academy Of Science Volume 79, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

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Prevalence And Genotypes Of Enterocytozoon Bieneusi In Captive Wild Hedgehogs (Erinaceus Amurensis) In China, Guo-Liang Chen, Yu-Lin Zhou, Xin Liu, Ming Shu, Can Yin Jun 2026

Prevalence And Genotypes Of Enterocytozoon Bieneusi In Captive Wild Hedgehogs (Erinaceus Amurensis) In China, Guo-Liang Chen, Yu-Lin Zhou, Xin Liu, Ming Shu, Can Yin

The Thai Journal of Veterinary Medicine

Enterocytozoon bieneusi is now recognised as an emerging pathogen, which can cause a series of intestinal diseases in humans and animals. However, limited information is available about the occurrence of E. bieneusi in hedgehogs. In this study, a total of 205 fecal samples of captive wild hedgehogs (Erinaceus amurensis) were collected from two wildlife conservation centers in Henan and Anhui provinces, China. Genomic DNA was extracted from the stool samples and screened by nested PCR targeting the internal transcribed spacer (ITS) sequences. The overall prevalence of E. bieneusi in captive wild hedgehogs was 44.4% (91/205). Five zoonotic genotypes were identified, …

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Implementasi Lean Management Untuk Efisiensi Pengelolaan Linen Dan Kesesuaian Standar Pencegahan Dan Pengendalian Infeksi Di Rsu X, Rionugrah Sari, Alih Germas Kodyat, Apri Sunadi Jun 2026

Implementasi Lean Management Untuk Efisiensi Pengelolaan Linen Dan Kesesuaian Standar Pencegahan Dan Pengendalian Infeksi Di Rsu X, Rionugrah Sari, Alih Germas Kodyat, Apri Sunadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Linen management is an important process in hospitals that is directly related to service quality and Infection Prevention and Control (IPC) efforts. This study aimed to analyze the implementation of Lean Management in linen management at the laundry unit of RSU X and to evaluate its contribution to improving process efficiency and strengthening IPC practices. The study employed an operational research design with a qualitative approach through observation, in-depth interviews, and document review. Data analysis was conducted using Value Stream Mapping, waste identification based on the eight waste concept, and root cause analysis using the 5 Whys method. The results …

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Reducing Postpartum Hemorrhage Through Evidence-Based Interventions, Ciara Hamilton, Mallory Mock, Liza Baker Jun 2026

Reducing Postpartum Hemorrhage Through Evidence-Based Interventions, Ciara Hamilton, Mallory Mock, Liza Baker

Cohort 36

No abstract provided.

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Understanding Delirium In Icu Patients: The Role Of Nurses And Noise Reduction, Eanna Mari Almerol, Aonima Kalam, Mansurun Rahman Jun 2026

Understanding Delirium In Icu Patients: The Role Of Nurses And Noise Reduction, Eanna Mari Almerol, Aonima Kalam, Mansurun Rahman

Cohort 36

No abstract provided.

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Community Perceptions And Hospital Selection In Depok: A Comparative Study Of Rsud Anugerah Sehat Afiat And Competitors Based On The 5a Framework, Iva Nur Faridah, Wahyu Sulistiadi Jun 2026

Community Perceptions And Hospital Selection In Depok: A Comparative Study Of Rsud Anugerah Sehat Afiat And Competitors Based On The 5a Framework, Iva Nur Faridah, Wahyu Sulistiadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

RSUD Anugerah Sehat Afiat (ASA) Depok faces challenges in enhancing service utilization and competitiveness as a public hospital in the increasingly competitive healthcare environment of eastern Depok City. This study aimed to identify factors influencing community preferences in hospital selection and to determine appropriate positioning strategies for RSUD ASA. A mixed-methods case study design was employed. Quantitative data were collected from 132 respondents aged over 25 years who had visited four hospitals included in the study, using structured questionnaires. Qualitative data were obtained through in-depth interviews with eight key informants representing RSUD ASA management. Data analysis was based on five …

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Pengetahuan Dan Motivasi Meningkatkan Penggunaan Aplikasi Mobile Jkn Pada Pasien Bpjs Di Instalasi Rawat Jalan Rsd Idaman Banjarbaru, Salbia Putri Kanzha Khairunnisa, Raziansyah Raziansyah, Fahriadi Fahriadi Jun 2026

Pengetahuan Dan Motivasi Meningkatkan Penggunaan Aplikasi Mobile Jkn Pada Pasien Bpjs Di Instalasi Rawat Jalan Rsd Idaman Banjarbaru, Salbia Putri Kanzha Khairunnisa, Raziansyah Raziansyah, Fahriadi Fahriadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The development of digital health services encourages the use of the Mobile JKN application to enhance access and service efficiency for BPJS participants. However, its utilization remains inconsistent due to limited knowledge of its functions and low motivation to use it. This study examined the relationship between knowledge and motivation with the use of the Mobile JKN application among BPJS patients at the Outpatient Installation of RSD Idaman Banjarbaru in 2025. This study employed a quantitative approach with a cross-sectional design. The population comprised 10,478 BPJS patients, while the sample consisted of 100 outpatient BPJS patients who used the Mobile …

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Exploring The Determinants Of Operating Room Utilization: A Scoping Review Of Influential Factors In Surgical Efficiency, Isma Sari Chumairah, Masyitoh Basabih Jun 2026

Exploring The Determinants Of Operating Room Utilization: A Scoping Review Of Influential Factors In Surgical Efficiency, Isma Sari Chumairah, Masyitoh Basabih

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Optimal utilization of the operating room (OR) is a crucial element in improving the efficiency of surgical services and hospital performance. This scoping review aimed to identify and map the factors influencing OR utilization based on recent scientific literature. We conducted a scoping review using the Population–Concept–Context (PCC) framework and reported it according to the PRISMA-ScR guidelines. We systematically searched PubMed, Scopus, and ScienceDirect for articles published between 2015 and 2025. Eligible studies were screened, and information on study characteristics and reported determinants of OR utilization was extracted and summarized descriptively. Forty studies were included. The reported determinants clustered into …

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Gambaran Administrasi Rekam Medis Semi-Digital Berdasarkan Pendekatan 5m Dan Poac Di Rsu X Kota Depok Tahun 2025, Dewi Shinta, Risky Kusuma Hartono, Malihah Ramadhani Rum Jun 2026

Gambaran Administrasi Rekam Medis Semi-Digital Berdasarkan Pendekatan 5m Dan Poac Di Rsu X Kota Depok Tahun 2025, Dewi Shinta, Risky Kusuma Hartono, Malihah Ramadhani Rum

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Medical record administration is an essential component in supporting healthcare service quality. During the transition toward Electronic Medical Records (EMR), many hospitals still use semi-digital systems that combine conventional and electronic processes. This study aimed to describe semi-digital medical record administration at RSU X, Depok City, based on the Man, Money, Material, Method, and Machine (5M) management elements and the Planning, Organizing, Actuating, and Controlling (POAC) management functions. This study employed a descriptive qualitative approach through in-depth interviews and observations involving five informants. The results showed that the semi-digital system operated through the parallel use of physical medical records and …

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Turning Up The Healing: Pressure Injury Prevention, Abdullah Mahdi, Chiliah Harper, Dylan Giofu, Jessica Hamilton, Ronnie Bryans, Jonathan Buck Jun 2026

Turning Up The Healing: Pressure Injury Prevention, Abdullah Mahdi, Chiliah Harper, Dylan Giofu, Jessica Hamilton, Ronnie Bryans, Jonathan Buck

Cohort 36

No abstract provided.

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How Does Taking A Non-Meaningful Break, As An Inpatient Nurse, Affect Nurse Turnover And Burnout?, Samantha Apil, Fatuma Fofana, Olivia Crawford, Jacqueline Nenninger, Tonesia Nesbitt, Rayyan Zeini Jun 2026

How Does Taking A Non-Meaningful Break, As An Inpatient Nurse, Affect Nurse Turnover And Burnout?, Samantha Apil, Fatuma Fofana, Olivia Crawford, Jacqueline Nenninger, Tonesia Nesbitt, Rayyan Zeini

Cohort 36

No abstract provided.

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No-Fly Zone: Protecting Patient Safety During Shift Change, Briana Fecteau Jun 2026

No-Fly Zone: Protecting Patient Safety During Shift Change, Briana Fecteau

Cohort 36

No abstract provided.

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Effect Of Individualised Homoeopathic Treatment In Case Of Vulval Vitiligo In An 8-Year-Old Girl: A Case Report, Sonia Raizada, Minakshi Kamboj Jun 2026

Effect Of Individualised Homoeopathic Treatment In Case Of Vulval Vitiligo In An 8-Year-Old Girl: A Case Report, Sonia Raizada, Minakshi Kamboj

Indian Journal of Research in Homoeopathy

Introduction: Vitiligo is an autoimmune skin condition that causes white patches due to loss of pigment-producing cells. This condition often significantly affects the self-esteem and emotional well-being of the affected person, requiring a holistic approach for treatment of such conditions. Case Summary: An 8-year-old girl was brought in with pale, depigmented patches on her genital area. Based on clinical presentation, a diagnosis of vitiligo was made. She underwent individualised homoeopathic treatment and was followed over for a period of seven months. During this period, visible re-pigmentation was observed, supported by photographic evidence and a decrease in her VETI score from …

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Vocal Fold Nodules In An 11-Year-Old Boy Treated With An Individualised Homoeopathic Medicine: A Case Report, Shivani Singh, Mahendra Pal Singh Jun 2026

Vocal Fold Nodules In An 11-Year-Old Boy Treated With An Individualised Homoeopathic Medicine: A Case Report, Shivani Singh, Mahendra Pal Singh

Indian Journal of Research in Homoeopathy

Introduction: Vocal fold nodules (VFNs) are a primary contributor to childhood dysphonia, accounting for about 63% of cases involving voice disturbances. They have a potentially negative impact over the Quality of Life (QoL), including diminished self-esteem and academic performance. The conventional management for voice improvement varies from vocal hygiene and voice therapy to endo-laryngeal microsurgery. This case illustrates the usefulness of Homoeopathy in managing VFNs. Case Summary: An 11-year-old boy presented with a year-long history of painless hoarseness of voice. He was diagnosed with VFNs and underwent extensive conventional treatment, without any improvement. The initial subjective assessment was done using …

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Management Of Submandibular Sialolithiasis With Homoeopathic Medicine Mercurius: A Case Report, Partha Pratim Pal, Laijun Nahar, Faiza Khan Jun 2026

Management Of Submandibular Sialolithiasis With Homoeopathic Medicine Mercurius: A Case Report, Partha Pratim Pal, Laijun Nahar, Faiza Khan

Indian Journal of Research in Homoeopathy

Introduction: Sialolithiasis is one of the most prevalent conditions affecting the salivary glands. Sialolithiasis is frequently encountered in clinical practice. A literature search reveals very few reported examples of non-surgical therapy because surgery is thought to be the main option for this clinical situation. Case summary: A 35-year-old female patient presented with symptoms of swelling and pain below the tongue since last two months. The homoeopathic medicine, Mercurius was prescribed at centesimal potency following the construction of the totality and repertorisation, and this led to the expulsion of the stone in three months and an improvement in the related symptoms. …

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