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Winter 1979, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Winter 1979

The Response Of Elderly Hospitalized Patients To Nurses' Use Of Expressive Touch, Theresa Lynn Burgett

Nursing ETDs

The purpose of this research was to determine the subjective reactions of elderly hospitalized patients to the use and non-use of expressive touch by nurses. Expressive and instrumental touch and personal and non-personal talk were operationally defined.

The sample of 23 elderly patients consisted of 15 females and 8 males. The mean age of the sample was 76.4 years.

The unit of study was the patient's bath. A repeated measures quasi--experimental design was utilized. Each patient received both the control and experimental interaction. The control interaction involved the use of instrumental touch only and the experimental interaction both instrumental and …

Dentos 1979, Chicago College Of Dental Surgery

Chicago College of Dental Surgery Yearbooks

No abstract provided.

Cme Seminar, Drug Interaction Flyer, 1979, New England College Of Osteopathic Medicine

William F. Bergen, D.O. Collection

Flyer advertising a Continuing Medical Education Seminar entitled "Drug Interaction" on April 28, 1979.

Introduction, David W. Richardson

MCV/Q, Medical College of Virginia Quarterly

The 50th McGuire Lecture Series presented current reviews in clinical cardiology and hypertension for practicing physicians and medical students. Speakers were members of the faculty of the Divisions of Cardiology and Cardiovascular Surgery at the Medical College of Virginia and Dean T. Mason, M.D., Chief of the Cardiovascular Section at the University of California at Davis. Dr. Mason, who is the outstanding authority on the management of congestive heart failure by reduction of the load against which the heart must pump, was the McGuire Lecturer.

Indications For Cardiac Catheterization In The Diagnosis And Management Of Coronary Artery Disease, George W. Vetrovec

MCV/Q, Medical College of Virginia Quarterly

In 1979 coronary angiography remains the standard test for diagnosing the presence and extent of coronary artery disease. Non-invasive studies such as exercise testing are only relative predictors of coronary anatomy. Therefore, to define specifically whether or not coronary disease exists in a given patient and, if present, to delineate its location, severity and the potential for bypass surgery, a coronary angiogram is the test to obtain. The purpose of this paper is to discuss indications for coronary angiography in the management of patients with established or suspected coronary disease.

Recent Advances In The Management Of Chronic Airway Obstruction, James A. L. Mathers Jr.

MCV/Q, Medical College of Virginia Quarterly

Recent advances in our understanding of the natural history of chronic airway obstruction have identified aspects of this process that may enhance the morbidity and mortality of patients with a progressive increase in airway resistance. These advances have helped us to be more specific in the investigation and quantitation of the disease in the pulmonary function laboratory and to be more precise in our therapeutic management. Experience has taught us that the most useful measurement with which to characterize the degree of disease and its rate of progression is the forced expired volume in one second (FEV1). The comprehensive studies …

Introduction, Edwin C. Myer

MCV/Q, Medical College of Virginia Quarterly

Many theories have been expounded as to the cause of Sudden Infant Death, not the least of which are those reports in the newspapers. This symposium covers the problem of etiology, pathophysiology, and the recognition of the at-risk infant, the management of the Sudden Infant Death victim, parents and the family, was well as efforts to prevent the occurrence of this event.

The Parents' Reaction, Suzanne Rowdon

MCV/Q, Medical College of Virginia Quarterly

As I sit here it appears to me that most you are aware of SIDS through your profession and education. My awareness came like a lightning bolt one sunny afternoon when I was getting ready for Thanksgiving dinner. It left a wound that is very slow to heal and my reaction from that continues to this day.

Emergency Room Procedure, David A. Draper

MCV/Q, Medical College of Virginia Quarterly

After having sat here and listened to the panel and particularly to Sue Rowdon describe her experience with her child’s death, I think it has been amply explained what emergency room procedure ought to be. Obviously, there has to be someone to take responsibility for evaluating the infant, and generally that person is going to be a physician. At the same time there has to be someone who can be attentive and compassionate to the family. The physician needs to recognize and explain some of the thoughts that must be going through the parents’ minds, such as, What’s wrong? What’s …

The Counseling Visit

MCV/Q, Medical College of Virginia Quarterly

The counseling opportunity for the health professional is generally referred to as the “home visit.” While the most valuable setting for assistance to the family is probably within the home setting, it should be recognized that other areas or settings can be utilized. Periodically, the telephone may be the only means of reaching the family. The decision as to where the counseling visit should take place rests with the family and the counselor. The counseling visit is an option for the family and may be refused by them. It is suggested that families in a period of grief do not …

Volume Fifteen Table Of Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1979, Volume Fifteen.

Volume Fifteen Author Index

MCV/Q, Medical College of Virginia Quarterly

Author Index for MCV/Q, Medical College of Virginia Quarterly, 1979, Volume Fifteen.

Early Diagnosis Of Relapse In Acute Myeloblastic Leukemia — Serologic Detection Of Leukemia-Associated Antigens In Human Marrow, Michael A. Baker , M.D., Judith A. Falk , B.Sc., Walter H. Carter , Ph.D., Robert N. Taub , M.D., Ph.D.

Internal Medicine Publications

Abstract

We tested serial bone-marrow samples from 47 adults with acute myeloblastic leukemia in remission for reactivity with heteroantiserums to leukemia-associated antigens, to determine whether imminent relapse could be detected in patients with acute leukemia. Of 26 patients who relapsed by standard morphologic criteria, 21 had increased immunoreactivity of bone marrow for one to six months (mean, 3.7 months) before relapse. High concordance was observed between a positive test and relapse during the period of study (chi-square = 27.53, P

Human Infection From An Unidentified Erythrocyte-Associated Bacterium, Gordon L. Archer , M.D., Philip H. Coleman , D.V.M., Ph.D., Roger M. Cole , M.D., Ph.D., Richard J. Duma , M.D., Ph.D., Charles L. Johnston , Jr., M.D.

Internal Medicine Publications

Abstract

A 49-year-old splenectomized man had an infection from an unidentified, gram-positive, rodshaped bacterium that adhered to the majority of his peripheral-blood erythrocytes. On transmission electron microscopy, the bacterium was seen to be extraerythrocytic and was 0.2 μm wide by 1.0 to 1.7 μm long. It possessed a thick, granular cell wall, a trilamellar membrane external to the cell wall and prominent mesosomes. Attempts to cultivate the organism in vitro or to duplicate the patient's disease in splenectomized animals were unsuccessful. The patient's response suggested that the bacterium was susceptible to cell-wall-active antibiotics and to chloramphenicol but not to tetracycline. …

A Comparison Of Amphotericin B Alone And Combined With Flucytosine In The Treatment Of Cryptoccal Meningitis, John E. Bennett , M.D., William E. Dismukes , M.D., Richard J. Duma , M.D., Gerald Medoff , M.D., Merle A. Sande , M.D., Harry Gallis , M.D., John Leonard , M.D., Branch T. Fields , M.D., Major Bradshaw , M.D., Hubert Haywood , M.D., Zell A. Mcgee , M.D., Thomas R. Cate , M.D., C. Glenn Cobbs , M.D., John F. Warner , M.D., David W. Alling , M.D., Ph.D.

Internal Medicine Publications

Abstract

We compared amphotericin B therapy for cryptococcal meningitis with a newer regimen containing both amphotericin B and flucytosine. In 50 patients with 51 courses of therapy adherent to the protocol, 27 courses were with amphotericin B and 24 with the combination. Even though the combination regimen was given for only six weeks and amphotericin B for 10 weeks, the combination cured or improved more patients (16 vs. 11), produced fewer failures or relapses (three vs. 11), more rapid sterilization of the cerebrospinal fluid (P<0.001) and less nephrotoxicity (P<0.05) than did amphotericin B alone. The number of deaths was the same (five) with each regimen. Adverse reactions to flucytosine occurred in 11 of 34 patients but were not life threatening. We conclude that combined flucytosine-amphoericin B therapy is the regimen of choice in cryptococcal meningitis. (N Engl J Med 301:126–131, 1979)

[Beta]-(2-Hydroxyphenyl)Ethanolamine Hydrochloride [2-Amino-1-(2-Hydroxyphenyl)Ethanol Hydrochloride], Alexandros Makriyannis, James B. Anderson, Joseph T. Dipiro, Edward Kostiner, Gilbert Hite

Publications from the Office of the Dean

CsH~2NO2+.C1 -, m.p. 441-449 K (from ethyl acetate), P212~2 l, a = 7.363 (2), b = 21.824 (6), c = 5.790 (2)/~, Z = 4, D x = 1.354, D m = 1.356 Mg m -3 (flotation: CC14-C6H6). The structure was solved by MULTAN. Full-matrix least-squares refinement converged to R = 0.057 for the R configuration and to R = 0.056 for the S configuration (P < 0.05). This is consistent with spontaneous resolution of the title compound, single crystals of which provided optically active aqueous solutions. A partially occupied oxygen site O(1)' is attributed to the oxidation of the alkyl hydroxyl group to a ketone during the data collection. The CI- is hydrogen bonded to H2(N)554, H3(N)555, and 1-t(O2)655 (2.37, 2-19, and 2.10 A). Both O(1) and 0(2) are internally hydrogen bonded [HI(N)...O(1), 2.41 and H(O1)...O(2) = 2.24 A]. Intramolecular hydrogen bonding may account for the unusual pharmacological properties of this compound in which only the N-C(1)-C(2)-O(1) and the O(1)-C(2)- C(3)-C(4) and O(1)-C(2)-C(3)-C(8) torsion angles (-41, -60, +122 ° ) differ significantly from those of other phenylethanolamines.

Interplanetary Magnetic Field Sector Polarity And Neuropsychiatric Adaption: A Reanalysis, Hans W. Wendt

Journal of the Minnesota Academy of Science

Recent Russian studies reported associations between adaptation syndromes and (solar activity-related) interplanetary magnetic field (IMF) sector polarity. Certain ambiguities in the original work suggested some reanalyses, based on the graphs and data made available. Syndrome status exhibited a biphasic (semi annual) trend. It also correlated with specific geomagnetic changes during magnetic storms and possibly after sudden impulses. Moreover, lag effects and higher order interactions were noted among all parameters investigated. The restudy tends to support some of the original findings but also suggests new conclusions regarding potential relationships between geophysical/solar and psychophysiological processes.

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1979, Volume Fifteen, Number One.

Afterload Reduction Therapy For Congestive Heart Failure, Dean T. Mason

MCV/Q, Medical College of Virginia Quarterly

The most important recent advance in the medical management of patients with acute and chronic congestive heart failure has been the application of systemic vasodilator drugs to reduce ventricular afterload, thereby improving low cardiac output and decreasing increased venous pressure. Although such drugs have been employed for several years to treat essential hypertension, hypertensive heart failure, acute hypertensive crises, and angina pectoris, only in the past five years has their use become widely popular in the therapy of normotensive heart failure. While it can be reasoned that the vasodilator approach is a logical therapeutic extension of fundamental determinants regulating cardiac …

Diseases Which Mimic Asthma And Chronic Obstructive Pulmonary Disease (Copd), George W. Burke Iii

MCV/Q, Medical College of Virginia Quarterly

The American Thoracic Society defines asthma as a disease characterized by increased responsiveness of the trachea and bronchi to various stimuli and manifested by widespread narrowing of the airways that changes in severity either spontaneously or as a result of therapy. In this context asthma is a physiologic diagnosis. It is most often recognized when a patient complains of episodic wheezing and dyspnea and most often confirmed by the demonstration of variable airways obstruction on spirometric testing.

Newer Drugs And Their Use In The Treatment Of Bronchial Asthma, Orhan Muren

MCV/Q, Medical College of Virginia Quarterly

The current knowledge of pathophysiology and new medications, as well as the better use of old ones, has significantly improved the therapy and prognosis of patients with bronchial asthma. However, it should be understood that drug therapy is beneficial only when aggravating or precipitating agents have been eliminated from the patient’s environment; these include allergens, such as dust, mold, pollens and other irritants, infection, exercise, psychological disturbances, certain drugs (aspirin), and stimulation of irritant receptors in the respiratory tract. There are five major classes of drugs used in treating bronchial asthma: (1) adrenergic agents, (2) xanthines, (3) corticosteroids, (4) cromolyn …

The Guild For Infant Survival, Joanne Hesbach

MCV/Q, Medical College of Virginia Quarterly

The Central Virginia Guild was started in 1976 by three families who did not know each other. We had one family who had lost a child to SIDS and two families who had babies on monitors. We all shared the same goal – we wanted to see an end to SIDS some day. We joined together and started a guild here with tremendous cooperation from the medical community. We worked mostly with Dr. David Draper and Dr. Edwin Myer.

The Role Of The Exercise Stress Test In The Adult, Donald W. Romhilt

MCV/Q, Medical College of Virginia Quarterly

The use, limitations, and value of the exercise stress test have been under debate in the recent cardiology literature. The purpose of this discussion is to examine the current role of the stress test.

Medical Management Of Angina, Andrea Hastillo

MCV/Q, Medical College of Virginia Quarterly

Evaluation of medical therapy of angina pectoris can be approached in many ways, but the objectives remain the same: (1) to relieve the acute attack of angina pectoris, (2) to prevent its recurrence, (3) to allow the patient to lead a normal lifestyle or, at least, one that is acceptable to him or her, and (4) to prevent myocardial infarction.

The Management Of Patients With Premature Ventricular Contractions, Donald W. Romhilt

MCV/Q, Medical College of Virginia Quarterly

Premature ventricular contractions (PVCs) occur frequently in patients with virtually all types of cardiac disease and in persons without evidence of cardiac disease. Since PVCs and advanced grades of PVCs are known to be predictors for ventricular fibrillation, increased mortality, and sudden death in certain clinical settings, the management of patients with PVCs is frequently based on the clinical setting in which they occur. For the purpose of this talk we will discuss the treatment of PVCs in the following three instances: acute myocardial infarction in the coronary care unit, post-myocardial infarction patients, and persons without any evidence of organic …

Surgical Treatment Of Mitral Valve Disease, Zubair Ul Hassan

MCV/Q, Medical College of Virginia Quarterly

This paper discusses the indications for surgery in mitral valve disease by comparing the natural history of the disease, as it can best be determined from the literature, with the results of various surgical procedures. It may be stated at the outset, however, that there are no controlled studies comparing medical and surgical treatment nor are they likely to be carried out in the near future.

Scripta Medica: Hyperuricemic Nephropathy: A Complication Of Acute Leukemia In Children, James C. M. Chan

MCV/Q, Medical College of Virginia Quarterly

In order to provide a point of reference for a rational approach to the therapy of acute uricemic nephropathy, the metabolic pathways leading to the production of uric acid will be briefly reviewed. Uric acid is the end-product of adenine and guanine metabolism. Relevant to this discussion is the xanthine oxidase enzyme which catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid. In children with acute leukemia the increasing production and subsequent destruction of white blood cells result in the rapid elevation of uric acid concentration in the plasma, especially during treatment with antineoplastic drugs. This in …

Management Of The Difficult Hypertensive Patient, A. Jarrell Raper

MCV/Q, Medical College of Virginia Quarterly

Hypertension, while usually easily handled, can in certain patients present difficult problems in management. A history of stroke sometimes creates doubt as to the advisability of lowering the blood pressure as this might reduce flow to the brain, causing the patient to have another stroke. It is recognized that severe hypertensives clearly do better if they are treated, but the mild-to-moderate hypertensive patient with a history of stoke is a more difficult problem, and uncertainty about proper management has been so great that a large multicenter clinical trial – randomized, double-blind, and placebo-controlled – of 452 patients was done by …

Legal Aspects Of Sids, T. S. Ellis Iii, J. D. Harvard, D. L. Oxford

MCV/Q, Medical College of Virginia Quarterly

My remarks today focus on four legal aspects of SIDS; the first three are problems of long standing and the fourth is less well recognized, an immediate problem to some but more of a cloud on the horizon to others. At the outset, I want to emphasize that I bring you no certain solutions. Rather my more modest objective is to provide a focus and framework for further discussions.