Medicine and Health Sciences Commons^™

An In Vivo Screen Identifies Nat10 As A Master Regulator Of Brain Metastasis, Jocelyn F Chen, Peng Xu, Wesley L Cai, Huacui Chen, Emily Wingrove, Xiaojian Shi, Wenxue Li, Giulia Biancon, Meiling Zhang, Amer Balabaki, Ethan D Krop, Elianna Asare, Yangyi Zhang, Mingzhu Yin, Toma Tebaldi, Jordan L Meier, Thomas F Westbrook, Stephanie Halene, Yansheng Liu, Hongying Shen, Don X Nguyen, Qin Yan

Faculty, Staff and Students Publications

Emerging evidence has shown that epigenetic regulation plays a fundamental role in cancer metastasis, the major cause of cancer-related deaths. Here, we conducted an in vivo screen for vulnerabilities of brain metastasis and identified N-acetyltransferase 10 (NAT10) as a driver of brain metastasis. Knockdown of NAT10 restrains cancer cell proliferation and migration in vitro and tumor growth and brain metastasis in vivo. The poorly characterized RNA helicase domain of NAT10 is critical for cell growth in vitro, while both RNA helicase and NAT domains are essential for primary tumor growth and brain metastasis in vivo. Mechanically, NAT10 promotes the …

Patient Selection, Ventricular Tachycardia Substrate Delineation, And Data Transfer For Stereotactic Arrhythmia Radioablation: A Clinical Consensus Statement Of The European Heart Rhythm Association Of The European Society Of Cardiology And The Heart Rhythm Society, Katja Zeppenfeld, Clifford Robinson, Et Al.

2020-Current year OA Pubs

Stereotactic arrhythmia radioablation (STAR) is a novel, non-invasive, and promising treatment option for ventricular arrhythmias (VAs). It has been applied in highly selected patients mainly as bailout procedure, when (multiple) catheter ablations, together with anti-arrhythmic drugs, were unable to control the VAs. Despite the increasing clinical use, there is still limited knowledge of the acute and long-term response of normal and diseased myocardium to STAR. Acute toxicity appeared to be reasonably low, but potential late adverse effects may be underreported. Among published studies, the provided methodological information is often limited, and patient selection, target volume definition, methods for determination and …

The Emergence Of Human Primordial Germ Cell-Like Cells In Stem Cell-Derived Gastruloids, Jitesh Neupane, Gabriele Lubatti, Theresa Gross-Thebing, Mayra Luisa Ruiz Tejada Segura, Richard Butler, Sargon Gross-Thebing, Sabine Dietmann, Antonio Scialdone, M Azim Surani

2020-Current year OA Pubs

Most advances in early human postimplantation development depend on animal studies and stem cell-based embryo models. Here, we present self-organized three-dimensional human gastruloids (hGs) derived from embryonic stem cells. The transcriptome profile of day 3 hGs aligned with Carnegie stage 7 human gastrula, with cell types and differentiation trajectories consistent with human gastrulation. Notably, we observed the emergence of nascent primordial germ cell-like cells (PGCLCs), but without exogenous bone morphogenetic protein (BMP) signaling, which is essential for the PGCLC fate. A mutation in the

The Advantages Of Being A Nurse Extern, Raylynn Broaddus, Elle Covington

Scholars Week

New graduate nurses experience low confidence levels and increased anxiety due to the limited exposure in the hospital. Nurse extern programs allow nursing students to get more hands on experience in the hospital. Is their any advantages to this? Three different research articles show advantages that arise when students complete one of these programs.

Ebp Implementing Telehealth In Outpatient Settings, Kylee Scott, Ellianna Grammer

Scholars Week

This evidence based practice project is researching if the implementation in outpatient settings would be beneficial. Specifically in the emergency department for areas such as triage and collaboration with other physicians.

Benefits Of Patient-Care Simulations For Nurse Education, Emily Pawlak, Macy Mohon, Molly Lewis

Scholars Week

This presentation was created to inform first-semester nursing students about the importance of the simulation labs they will complete throughout their BSN schooling. The research conducted indicated that these mock experiences were substantially beneficial for how nursing students learned bedside manners and clinical skills. Simulations allow students to prepare themselves to interact with patients professionally and safely while working effectively to improve patient outcomes. Although the sim-lab is a controlled environment, the scenarios that students will graded on are very real scenarios they may encounter during their clinical rotations. Our project aimed to inform students about what they can expect …

The Importance Of Nurse Involvement In Hospitalized Patient Smoking Cessation, Eudora Larson

Scholars Week

No abstract provided.

Hospital Passports: A Plan To Improve Care Of Patients With Intellectual Disabilities, Monica Mcmanemin, Kat Mccollum, Brianna Dennis

Scholars Week

Patients with intellectual disabilities frequent hospital settings, but often face barriers in communication and care due to altered needs that cannot be expressed. From these barriers hospital staff also experience frustrations in caring for these patients. Research supports that hospital passports are an excellent solution to improving care for patients with intellectual disabilities. These documents create a clear outline for hospital staff of these patients’ individual needs and allow reasonable adjustments to be made. This ensures that high quality care can be provided to all patients while also relieving stress from the healthcare providers. The goal of this project is …

Enhancing Cauti Prevention Through Daily Catheter Care Charting, Pre-Packaged Wipes, And Targeted Nursing Education, Alexis Bartolo, Hannah Todd, David Wagner

Scholars Week

Catheter-associated urinary tract infections (CAUTIs) are common healthcare-associated infections that increase patient morbidity, mortality, and healthcare costs. This evidence-based project aims to reduce CAUTIs by implementing daily catheter care charting, using pre-packaged antiseptic wipes, and providing targeted nursing education. These interventions will enhance accountability, improve hygiene practices, and equip nurses with the latest CAUTI prevention techniques. The project evaluates the current catheter care policy, comparing it with evidence-based practices to identify improvements. Guided by Dorothea Orem’s Self-Care Deficit Theory, the proposed policy changes aim to improve patient safety and care quality. By integrating these interventions into routine practice, the project …

Benefits Of Nursing Touch In Neonates, Lacy Baldwin, Camila Canedo Muzevic

Scholars Week

This paper explores the benefits of nursing neonatal soothing techniques, focusing on their short- and long-term effects in reducing stress and their influence on development. It emphasizes the nursing role through Kolcaba’s Theory of Comfort in providing proactive non-pharmacological care. Neonates, particularly preemies, face significant amounts of stress in the clinical setting which can impede proper growth and development, as well as immediate well-being. It is part of the nursing duty to alleviate stress and promote comfort. This project analyzes evidence-based research on soothing techniques, including tactile, kinesthetic, gentle human touch, interactive newborn bathing, etc. It demonstrates the positive outcomes …

The Implementation Of Music Therapy For Dementia Patients, Lauren Holcomb, Jessica Borror, Jenna Schanz

Scholars Week

This research looks into the implementation of music therapy for dementia patients in several different clinical settings. The framework for the research takes a look at person-centered nursing care which focuses on the patient as an individual with specific wants and needs.

After reviewing the research articles, aspects of changing patient care like adding implementations of personal speakers and playing music in group settings were brought up as recommendations for facilities caring for dementia patients.

With these recommendations, we believe that there will be a reduced use of pharmacological interventions for behavioral outbursts and reduce the use of restraints. Most …

Evidence Based Practice Presentation: Proper Use Of Personal Protective Equipment Protecting Health Care Workers, Bella Batts, Kristine Puckett, Jimena Calderon

Scholars Week

Personal protective equipment (PPE) is essential in safeguarding healthcare workers from exposure to infectious agents, hazardous substances, and physical risks in clinical environments. PPE includes a variety of items such as gloves, masks, face shields, gowns, and respirators, each designed to provide a barrier between healthcare workers and potentially harmful pathogens or environmental hazards. The use of PPE is particularly crucial in settings where healthcare workers are at heightened risk, such as during the treatment of patients with infectious diseases, surgical procedures, or when handling hazardous materials. The importance of PPE extends beyond individual protection, as it helps reduce the …

Mental Activities For Older Adults To Promote Cognitive Function, Paige Kramer, Riley Hancock

Scholars Week

Addressing mental activities for older adults to promote cognitive function while hospitalized. Implementing evidence-based practices that can help promote cognitive function such as crossword puzzles, word searches, art, and music therapy. Providing staff education on why cognitive function is important. Mental activities are essential needs that need to be addressed for patients.

Improving Recovery Nurses’ Satisfaction With Postoperative Transfer Of The Anesthetized Patient With The Utilization Of A Standardized Handoff Checklist, Gemma Nilsson

Scholars Week

Aim: To evaluate the effectiveness of using a standardized tool during patient handoff, addressing the lack of an organized structure for patient transfers and the risk of miscommunication. Poor communication is a leading cause of medical errors in the hospital and the transfer reports of postoperative patients in the post-anesthesia care unit are often inaccurate or incomplete (Milby, 2014; Salzwedel, 2012).

Design: A handoff tool was developed for anesthesia providers to use during postoperative patient transfers. Using descriptive statistics, the project evaluated subjective survey responses from registered nurses before and after the implementation of the tool. Perception of the tool’s …

Advancing Provider Knowledge On Precedex Use To Prevent Postoperative Delirium Through Targeted Education, Brian Gibbs

Scholars Week

Postoperative delirium (POD) is a serious and multifactorial complication commonly affecting elderly surgical patients. POD is associated with increased morbidity, longer hospital stays, and higher mortality rates. The use of benzodiazepines and opioids during the perioperative period is a significant modifiable risk factor for POD. Despite the potential of Dexmedetomidine (Precedex) to reduce POD incidence due to its sedative, and analgesic properties, it is not widely available in many operating rooms (OR). This project aimed to educate anesthesia providers on the benefits of Precedex and its role in reducing POD in patients over 65 years old. A quality improvement project …

Implementation Of A Mental Health Wellness Toolkit For Student Registered Nurse Anesthetists, Mckenzie Lawson

Scholars Week

There is significant evidence that proves that Student Registered Nurse Anesthetists score exceptionally high on stress and anxiety scales. Research has demonstrated that high levels of anxiety and stress can lead to burnout and mental health concerns, including depression, fatigue, substance abuse, and suicidal ideation. A PICOT question was developed for this problem and is as follows: For first-year student registered nurse anesthetists starting clinicals in the operating room, how does participating in a wellness program where students are taught stress-reduction techniques affect their stress and resiliency scores one month and three months following the implementation of the program? This …

Exploring A Rare Association: Rheumatoid Arthritis With Pachymeningitis And Optic Neuritis., Muhammad Umer Riaz Gondal, Josette Graves, Aafreen Khan, Praveen Kowtha, Zainab Kiyani, Richard Lukose, Gregory Emkey, Pavani Pagolu

Tower Health Research Day

No abstract provided.

Managing Hemodynamic Support In Mixed Serotonin Syndrome And Severe Bupropion Toxicity: A Case Report, Robert Nordell, Jennifer Jozefick

Tower Health Research Day

No abstract provided.

The Effect Of A Combined Aloe Vera And Chlorhexidine Gel On Plaque Index In Children With Cerebral Palsy. Randomized Controlled Clinical Trial), Anwar S. Sabti, Chaza N. Kouchaje, Mhd. Isam H. Agha

Arabian Journal of Pediatric Dentistry

Introduction: Background and aim of the research: Oral health and periodontal diseases constitute part of the oral problems in patients with cerebral palsy. Providing oral health care to these patients is extremely difficult due to some of their physical and physical disabilities. Given the existence of a link between oral health and physical health, it was necessary to think about In finding solutions to treat their gingivitis without exerting physical and mechanical effort on the part of the child and his family, and the fact that the use of oral rinses GEL is effective in alleviating gingivitis, it requires …

The Effect Of Sugar-Free Gum On The Salivary Ph Of Children After Consuming Sweetened Milk, Rouaa Zamzam, Nada Bshara

Arabian Journal of Pediatric Dentistry

Objectives: This study aimed to monitor the changes in saliva pH after consuming a package of sweetened and chocolate-flavored milk, then studying the saliva pH changes after consuming a sugar-free gum sweetened with xylitol and sorbitol, in children with different additionally dental caries at the age of 3-5 years after conducting a laboratory study of milk to measure its acidity and the amount of added sugars and proteins to it. Materials and Methods: : A chemical analytical laboratory studied the pH and the amount of sugar and proteins added to milk (sweetened and chocolate flavored milk from (Hawa Al …

The Influence Of Buffered And Conventional Anesthetic Solutions On The Pain Level In Children During An Inferior Alveolar Nerve Block Injection: Randomized Clinical Trial, Rouaa M. Hassan, Chaza N. Kouchaje, Hanadi Al-Mattit

Arabian Journal of Pediatric Dentistry

Objectives: The purpose of this study was to assess pulse rate as a physiological pain assessment during inferior alveolar nerve block injection using buffered anesthetic solution (lidocaine 2% epinephrine 1/80,000 with sodium bicarbonate 8.4%) and conventional anesthetic solution (lidocaine 2% epinephrine 1/80,000) to treat bilateral mandibular primary molars.

Materials and Methods: Forty patients were included in the study sample to perform 80 inferior alveolar nerve block injections with split-mouth technique in patients aged 6-10 years with bilaterally infected mandibular primary molars. A fingertip oximeter was used to measure the pulse rate before and during anesthesia.

Results: The pulse difference …

Evaluation Of Marginal Leakage Of Self-Adhesive Flowable Composite On Anterior Primary Teeth: In Vitro Study, Amani M. Habbal, Chaza N. Kouchaje

Arabian Journal of Pediatric Dentistry

Objectives: This study aims to evaluate the bonding of self-adhesive flowable composite in comparison with traditional flowable composite with a fifth-generation total-etch bonding system in primary anterior teeth, by studying microleakage after application of these materials in-vitro.

Materials and Methods: The study sample consisted of 32 extracted primary canine teeth. The sample was divided into two equal groups (n=16) according to the type of restoration applied: (Group 1): Traditional flowable composite resin was applied with a fifth-generation total-etch bonding system, (Group 2): Self-adhesive flowable composite resin was applied alone. A class v cavity was prepared on the facial/lingual surface …

Ai In Radiology: Bridging The Gap Between Technology And Patient Care, Jordan Watts, Jeffrey Larson, Kasi Gorli, Alberto Coustasse

Management Faculty Research

Artificial Intelligence (AI) integration in healthcare, particularly within radiology, has grown rapidly, with 400 out of 520 FDA-approved AI algorithms explicitly designed for radiological applications as of 2023. AI has shown significant potential for enhancing healthcare delivery and improving patient outcomes (AHA, 2023); however, understanding the barriers, facilitators, and implications of AI implementation in radiology remains fragmented across existing studies. This study investigates AI's impact on radiology in three critical areas: diagnostic accuracy, interpretation times, and clinical workflow efficiency. We synthesize key findings regarding AI's contributions to radiology practices through a comprehensive literature review of 29 articles published between 2015 …

Direct To Clinician Analytics: Providing Transparency Through Performance Reporting, Matthew Safern, Patrick Cockey

Jefferson Hospital Staff Papers and Presentations

Problem Statement

Jefferson Health expanded significantly after multiple mergers and acquisitions, incorporating diverse medical groups, operational models, and legacy data systems. However, this rapid growth introduced substantial challenges in maintaining a unified approach to clinician workforce analytics, performance measurement, and compensation standardization. This project aimed to deliver standard reports directly to clinicians seeking insight into their performance, compensation, and benchmarks.

Medical School Watercooler Newsletter - March 27, 2025, Lindsay Hughes

Watercooler Newsletter

This is the Thursday, March 27, 2025 edition of the Frederick P. Whiddon College of Medicine's newsletter -- Watercooler.

Contents include:

• EDGE for Success kicks off with connection, reflection and leadership growth
• Student Affairs welcomes new program coordinator
• Internal medicine residents focus on wellness during annual retreat
• Study explores impact of academic coach training on the coaches 
• Menger selected for national leadership training program

Colorectal Cancer Screening And Correlating Gender Disparities, Kara Marr, Megan Janssen, Margaret Payne, Laura Reed Dnp, Aprn, Fnp-Bc, Cne

Doctor of Nursing Practice Projects

Purpose/Background

In 2023, colorectal cancer (CRC) was the second leading cause of cancer-related deaths in the US, equating to approximately 50,000 total deaths (National Cancer Institute, 2024). Further, it is estimated that an additional 1.4 million Americans are living with CRC (National Cancer Institute, 2024). Early detection screening modalities remain imperative since the NIH has released a combined survival rate of 70% when utilized (National Cancer Institute, 2024). Different derivatives of CRC develop from pre-cancerous polyps and are often without signs or symptoms of disease progression; this asymptomatic period emphasizes the importance of early detection and prevention of colorectal cancer …

Patient Access As A Vehicle For Growth: Leveraging Technology & Stakeholder Engagement, Celeste Gagliardi, Ryan Patterson, Scott Guttridge

Jefferson Hospital Staff Papers and Presentations

Introduction Statement:

Prior to the work outlined here, Jefferson Medical Group's local scheduling controls led to inconsistent scheduling rules, inefficient staffing models, and a less than desirable patient experience. Fueled by the conversion to Epic in late 2016, JMG has been on a journey to improve access through technology enablers that have fostered significant growth for the organization while simultaneously improving the experiences of our patients, providers, and staff.

Evaluating A Large Language Model’S Accuracy In Chest X-Ray Interpretation For Acute Thoracic Conditions, Adam M. Ostrovsky

SKMC Student Presentations and Publications

BACKGROUND: The rapid advancement of artificial intelligence (AI) has great ability to impact healthcare. Chest X-rays are essential for diagnosing acute thoracic conditions in the emergency department (ED), but interpretation delays due to radiologist availability can impact clinical decision-making. AI models, including deep learning algorithms, have been explored for diagnostic support, but the potential of large language models (LLMs) in emergency radiology remains largely unexamined.

METHODS: This study assessed ChatGPT's feasibility in interpreting chest X-rays for acute thoracic conditions commonly encountered in the ED. A subset of 1400 images from the NIH Chest X-ray dataset was analyzed, representing seven pathology …

An Assessment Of The Performance Of Different Chatbots On Shoulder And Elbow Questions, Mohamad Y. Fares, Tarishi Parmar, Peter Boufadel, Mohammad Daher, Jonathan Berg, Austin Witt, Brian W. Hill, John G. Horneff, Adam Z. Khan, Joseph A. Abboud

Rothman Institute Papers

Background/Objectives: The utility of artificial intelligence (AI) in medical education has recently garnered significant interest, with several studies exploring its applications across various educational domains; however, its role in orthopedic education, particularly in shoulder and elbow surgery, remains scarcely studied. This study aims to evaluate the performance of multiple AI models in answering shoulder- and elbow-related questions from the AAOS ResStudy question bank.

Methods: A total of 50 shoulder- and elbow-related questions from the AAOS ResStudy question bank were selected for the study. Questions were categorized according to anatomical location, topic, concept, and difficulty. Each question, along with the …

Left Ventricular And Aortic Pressures Measured With Fluid-Filled And Solid-State Pressure Catheters: Similarities And Differences, Priscilla Machado, Ira Cohen, Brian Osler, Maureen E. Mcdonald, Cara Esposito, Marguerite Davis, David Fischman, Michael P. Savage, Praveen Mehrotra, Flemming Forsberg, Jaydev K. Dave

Division of Cardiology Faculty Papers

Objective: To compare left ventricular (LV) and aortic (AO) pressures obtained using fluid-filled and high-fidelity solid-state pressure catheters in subjects undergoing left heart catheterization.

Materials and Methods: Twenty subjects scheduled for a left heart catheterization were enrolled and 18 subjects completed this IRB-approved study. LV and AO pressures were obtained using fluid-filled pressure catheter (standard-of-care) and high-fidelity solid-state pressure catheter synchronously. Pressure tracings were analyzed to measure LV systolic (LVSP), LV minimum-diastolic (LVMDP), LV end-diastolic (LVEDP), AO systolic (AOSP), and AO diastolic (AODP) pressures. Isovolumic contraction and relaxation rates (peak ± dp/dt) were derived from the pressure waveforms. Repeated measures …