Medicine and Health Sciences Commons^™

Time Required To Implement A Computerized Patient Decision Aid For Lupus In Outpatient Visits, Nathan W Carroll, Aizhan Karabukayeva, Larry R Hearld, Diane Kamen, Alfred H J Kim, Sonali Narain, Narender Annapureddy, Zineb Aouhab, Maureen Mcmahon, Vikas Majithia, Cathy Lee Ching, Winn Chatham, Jasvinder A Singh

Faculty, Staff and Students Publications

BACKGROUND: Patient decision aids have the potential to lower decision conflict for patients and to improve patient-physician communication. However, uptake of decision aids has been poor, in part because the time required to incorporate these into clinical practice is not well understood.

OBJECTIVE: To estimate the time required for a rheumatology clinic to implement a validated decision aid for patients with lupus.

METHODS: Using a cohort of eight implementation sites, study investigators identified the activities required to administer a decision aid. Site coordinators embedded within the clinics timed the duration of each activity. To estimate the effect of viewing the …

Early Nintedanib Deployment In Covid-19 Interstitial Lung Disease (Endcov-I): Study Protocol Of A Randomised, Double-Blind, Placebo-Controlled Trial, Valeria Santibanez, Aditi Mathur, Jigna Zatakia, Nicole Ng, Michele Cohen, Emilia Bagiella, Stacey-Ann Brown, Ivan O Rosas, Nina M Patel, Amy Olson, Peide Li, Maria Padilla

Faculty, Staff and Students Publications

Introduction: In December 2019, the novel SARS-CoV-2 triggered a global pneumonia outbreak, leading to millions of deaths worldwide. A subset of survivors faces increased morbidity and mortality, particularly due to subacute lung injury evolving to chronic fibrosing interstitial lung disease. While nintedanib, a tyrosine-kinase inhibitor, shows promise in treating progressive fibrotic lung disease, limited randomised trial data exists for post-COVID-19-induced lung injury. We hypothesise that treatment with nintedanib may attenuate advancement to the fibrotic stages, offering a potential avenue for improving outcomes in this specific patient subset.

Methods and analysis: We describe the design of a multicentre, randomised, double-blind, placebo-controlled …

An Open-Label Study Evaluating The Safety And Efficacy Of Amo-01 For The Treatment Of Seizures In Phelan-Mcdermid Syndrome, Tess Levy, J Lloyd Holder, Joseph P Horrigan, Michael F Snape, Alison Mcmorn, Christina Layton, Hailey Silver, Kate Friedman, Hannah Grosman, Slayton Underwood, Danielle Halpern, Jessica Zweifach, Paige M Siper, Alexander Kolevzon

Duncan NRI Faculty and Staff Publications

Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder caused by haploinsufficiency of the SHANK3 gene. Approximately 25% of individuals with PMS have epilepsy. Treatment of epilepsy in PMS may require multiple anticonvulsants, and in a minority of cases, seizures remain poorly controlled. Converging lines of evidence in different experimental models indicate that the Ras-ERK pathway is implicated in the pathophysiology of seizure generation and neurobehavioral symptoms in PMS. The goal of this study was to evaluate the safety, tolerability, and efficacy in treating seizures in adults and adolescents with PMS using AMO-01, a Ras-ERK pathway inhibitor. A single 6-hour intravenous infusion …

The Cellular Trafficking And Targeting Of Angiotensin-Converting-Enzyme-2 (Ace2) And Neutral-Amino-Acid-Transporter (B0at1) Variants: Implications For The Pathogenesis Of Associated Diseases And Therapy, Nesreen Fayyad Al-Khofash

Thesis/ Dissertation Defenses

Angiotensin-converting enzyme 2 (ACE2) and the amino acid transporter B0AT1 are essential for blood pressure regulation, amino acid absorption, and viral entry. Their interaction is crucial in both normal physiology and disease, including hypertension, Hartnup disease, and SARS-CoV-2 infection. However, the effects of genetic variants on their biogenesis, trafficking, and function remain poorly understood. This PhD thesis investigates how specific ACE2 and B0AT1 variants influence their subcellular localization and interactions. A multidisciplinary approach, incorporating site-directed mutagenesis, confocal microscopy, Western blotting, and in silico modelling, was used to examine 39 ACE2 variants and 18 B0AT1 mutations. Results showed that wild-type ACE2 …

Race And Gender Bias In Sports Media, Jovanni Salazar

Research Days

There is a significant amount of racial and gender bias in sports media, which can impact the way minority and female athletes are perceived by the public. This study closely looks at the way these professional athletes are talked about and treated by the media compared to white athletes. This study highlights the language used by commentators and other members of sports media that reinforces negative stereotypes that minority and female athletes deal with throughout their careers. Some of these stereotypes imply black athletes owe their success to natural physical ability, while white athletes are “smart” and more “skilled. This …

Research And Engagement Day Poster

Bryant REDay (Research and Engagement Day)

No abstract provided.

Bryant's Ai Hack-A-Thon

Bryant REDay (Research and Engagement Day)

No abstract provided.

Research And Engagement Day Poster

Bryant REDay (Research and Engagement Day)

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Bryant University Research And Engagement Day Program

Bryant REDay (Research and Engagement Day)

No abstract provided.

Research And Engagement Day Poster

Bryant REDay (Research and Engagement Day)

No abstract provided.

87 - Maternal Dental Status And Caries Among Siblings, Monica Walker, Charity Hammond, Angela Wilson, Denise Mckinney, Katie Protogyrou

Undergraduate Research Symposium

Research has suggested that birth order or environmental factors affect siblings' oral health status during childhood. However, more recent research suggests that the strongest predictor of children's oral health status is the mother's oral health status. This project investigated the association between the oral health status of the mother during pregnancy and bacteria (biofilms) identified in cavitated lesions (dental caries) of their children’s exfoliated primary teeth. Five consenting maternal participants anonymously donated their children's primary teeth and completed a questionnaire about their oral health status during each pregnancy. After visually identifying the exfoliated teeth with dental caries, the biofilms were …

Unlocking Nature’S Pharmacy: Using Hidden Secrets From Post Famine Ireland To Direct Modern Scientific Exploration Of Irish Bogland Species., Helen Sheridan

Oxford ICSB

Boglands are iconic landscapes and important carbon sinks, extending across the northern hemisphere, covering approximately 20% of Ireland's land area. These ancient water-logged ecosystems are reservoirs of a unique biodiversity adapted to survive in nutrient-poor yet strikingly beautiful environments. Irish mythology is deeply connected to boglands, featuring stories about healing plants, fairies, and ancient curses. Irish communities historically used bogland plants for their medicinal properties. Many uses are recorded in the Schools' Manuscript Collection (SMC) (1937-1939), a treasure-trove of Irish folklore, customs, and ethnographic data, collected as part of the Irish Folklore Commission's effort to preserve Ireland’s oral traditions (Dúchas.ie). …

The Contribution Of The European Pharmacopoeia To The Quality Control Of Herbal Medicinal Products, Salvador Canigueral

Oxford ICSB

The European Pharmacopoeia (Ph. Eur.) is an international regulatory document setting the standards for the quality control of medicinal products. It is elaborated by the European Directorate for the Quality of Medicines & HealthCare (EDQM), a body of the Council of Europe, headquartered in Strasbourg, France. It is mandatory in 39 European countries and the European Union. The Ph. Eur. establishes quality specifications for active ingredients, excipients, dosage forms, and finished products. In relation to herbal medicinal products, the upcoming 12th Edition (effective January 2026) includes: 25 general methods in pharmacognosy, 6 general monographs, 2 information chapters, and 392 individual …

Sealing Ability Of White Mineral Trioxide Aggregate Mixed With 2.25% Sodium Hypochlorite Gel Used For Repairing Furcal Perforations In Primary Molars: An In Vitro Study, Mawia M. Karkoutly, Saleh B. Al Kurdi, Nada Bshara

Arabian Journal of Pediatric Dentistry

Objectives: This study aimed to evaluate the sealing ability of mineral trioxide aggregate (MTA) and 2.25% sodium hypochlorite (NaOCl) gel mixture in repairing furcal perforation in primary molars using methylene blue dye penetration.

Materials and methods:
It was an in vitro experimental study. Sixty human primary molars were randomly divided into four groups (n = 15). Group 1 (MTA + distilled water (DW)): Furcal perforations were repaired with MTA and DW mixture. Group 2 (MTA + NaOCl gel): Furcal perforations were repaired with MTA and 2.25% NaOCl gel mixture. Group 3 (Positive control): Furcal perforations left untreated. Group 4 (Negative …

Investigating The Impact Of Drug Delivery Systems On The Efficacy Of Emla Cream For Palatine Anesthesia In Children Aged 7 To 11 Years., Farah M. Babakurd, Shadi K. Azzawi

Arabian Journal of Pediatric Dentistry

Background & Aim: This research aims to find alternatives to the traditional painful palatine local injection used during the extraction of upper temporary teeth. The study seeks to enhance the effectiveness of EMLA cream over a suitable duration for child response (3 minutes) by utilizing drug delivery systems, including a permeability enhancer (DMSO), oral patches, and microneedle patches for palatine injections while using only lidocaine injections from the vestibular side.

Materials and Methods: The research sample consisted of 75 children, who were

randomly divided into five groups of 15 children each. The studied material or method was applied …

The Relationship Between Maternal Dental Anxiety And Children's Dental Anxiety: A Cross-Sectional Study, Mariam I. Sharaf, Mayssoon A. Dashash

Arabian Journal of Pediatric Dentistry

Background and aim of the study: Dental fear and anxiety are one of the main challenges in pediatric dentistry, and dental fear and anxiety are a common reason for avoiding dental treatments, which may lead to deterioration of oral health status over time. Many researchers have shown that the relationship between parents and children has a direct impact on dental anxiety in children, so this study was conducted with the aim of evaluating the relationship between dental anxiety in mothers and dental anxiety in children.

Materials and methods: This cross-sectional study was conducted on 60 children and their mothers …

Evaluating The Effectiveness Of Cinnamon Oil On Pain Severity Caused By Needle Pick During Inferior Alveolar Nerve Block In Children, Hiba N. Khalouf, Mohammad Bashier Al Monaqel

Arabian Journal of Pediatric Dentistry

Objectives: Despite the great development witnessed by dentistry, pain during the insertion of a local anesthesia needle is still the main cause of fear and anxiety in children, and with the spread of many methods to relieve pain, research is still ongoing to find an effective surface anesthetic to relieve pain well, so the aim of this research was to take advantage of the available and cheap non-pharmacological natural materials in achieving this goal.

Materials and Methods: A randomized, double-blind clinical study was conducted involving 60 children from the Pediatric Dentistry Department of Damascus University. Cooperative children were selected …

Comparing Two Types Of Distraction (Passive And Active) During Primary Mandibular Molar Pulpotomy (Randomized Controlled Trial), Ekram A. Alsibai, Nada Bshara

Arabian Journal of Pediatric Dentistry

Objectives: The aim of this study was to compare the types of passive distraction - by watching cartoons - and active distraction - by video games - during pulpotomy on the primary mandibular molars in children.

Materials and Methods: The research sample consisted of 70 children who were randomly divided into two groups according to the distraction method used:

Group (1): 35 children who used the active distraction technique by video games through a wireless gaming handpiece.

Group (2): 35 children who used the passive distraction technique by watching cartoons films.

Children were selected from the Department of Pediatric Dentistry …

Impact Of An Oral Health Education Program On Institutionalized Visually Impaired Children In Syria, Batool M. Al Mughrabi, Yusra H. Haddeh, Mayssoon A. Dashash

Arabian Journal of Pediatric Dentistry

Background: Children with visually impairments encounter numerous challenges in maintaining adequate oral hygiene. Their reliance on caregivers limits their ability to utilize visual aids and engage with the medical instructions typically found in standard dental health education programs.

Aim: The aim of this study was to evaluate the effectiveness of oral health education (OHE) delivered through two different methods: audio and tactile, on the Knowledge – attitude – behavior (KAB) related to oral health, as well as the oral health status of visually impaired children.

Material and Methods: A total of sixty-six visually impaired children, aged 5-18 years, residing at …

The Association Of Sleep Quality And Depression On Having Three Vs. All Five Diagnostic Criteria Of Metabolic Syndrome, Nina Pollard

Walden Dissertations and Doctoral Studies

Metabolic syndrome is increasing in prevalence in the United States. To be diagnosed, three of the five diagnostic criteria must be met. There is a higher risk of metabolic syndrome due to lifestyle and social factors, with increased criteria occurring as an individual has unmet social determinants of health. This quantitative quasi-experimental/quasi-comparative study examined the association between education level, with sleep quality and depression as moderators, on a diagnosis of metabolic syndrome with all five criteria versus three criteria using a binary logistic regression while controlling for age, race, gender, income, employment, and marital status. Bronfenbrenner’s social ecological theory served …

Heterozygous Hereditary Vitamin D-Dependent Rickets Type 2a (Vddr2a) In A Patient Presenting With Pseudoarthrosis, Risa Goldberg, Gunjan Umarji, Serge Jabbour

Division of Endocrinology, Diabetes and Metabolic Diseases Faculty Papers

This case report is centered on an atypical presentation of Hereditary Vitamin D-dependent Rickets 2A (VDDR2A), a rare disorder caused by defects in the gene encoding the vitamin D receptor (VDR). While this disorder is primarily autosomal recessive in inheritance, this case demonstrates that a single heterozygous variant in the VDR gene could be linked to both phenotypic and laboratory manifestations of this condition. To understand the pathogenesis of this condition, one must know the typical roles of vitamin D, calcium, and parathyroid hormone (PTH) in maintaining homeostasis in the body. This case report focuses on the underlying pathogenesis of …

Hdac5 Enzymatic Activity Regulates Scn4b Expression To Control Relapse-Like Cocaine Seeking, Daniel J. Wood

MUSC Theses and Dissertations

Substance Use Disorder (SUD) is a relapsing disorder characterized by repeated seeking and use of psychoactive substances despite negative consequences to the individual. Epigenetic changes within the medium spiny neurons (MSNs) of the nucleus accumbens (NAc) are thought to underly the lasting propensity to relapse in SUD. The epigenetic enzyme histone deacetylase 5 (HDAC5) in NAc MSNs limits the formation of reward-cue associations in rodent models of drug seeking, but not sucrose seeking, leading to decreased relapse-like behavior. However, whether HDAC5 reduces drug seeking behavior through its own deacetylase activity or through the recruitment of co-repressors is unknown. Furthermore, these …

Planning And Dissemination Of Quality Improvement Activities: A Qualitative Study Evaluating Barriers And Enablers To Implementation Of The Squire 2.0 Guidelines, Jessica Rose Phillips

Doctor of Philosophy in Translational Health Sciences Dissertations

Background: Quality improvement (QI) initiatives aim to systematically improve the efficiency and safety of healthcare provided to patients. These data-driven projects also seek to improve processes within the healthcare industry. Potential goals for quality improvement projects (QIPs) can include improving patient outcomes, improving healthcare access, increasing efficiency, and enhancing patient safety. While essential to improve care at the local level, QIPs are not without challenges. Currently, healthcare organizations plan and report the findings of these QIPs in non-standardized ways. This can lead to missing key details and the sharing of inaccurate results, among other things. The Standards for Quality Improvement …

Ready To Shine: A Framework For Coaching K-12 Educators To Support Diverse Learners, Kathleen Childs, Angela Blackwell, Katie Gebhart

Spring 2025 OTD Capstone Symposium

The Ready to Shine: A Framework for Coaching K-12 Educators to Support Diverse Learners is meant to guide occupational therapy practitioners in training and coaching educators to implement strategies to support students with social-emotional, behavioral, sensory, or other unique needs. Through this framework, practitioners will aim to equip educators with the confidence, self-efficacy, and competence to use tools and/or techniques that promote participation and performance among their students.

An Independent Living Skills Training Guide For Direct Support Professionals Working With People With Intellectual Or Developmental Disabilities, Nigel Yeo, Steven Gerardi Phd, Otd, Mss, Otr

Spring 2025 OTD Capstone Symposium

Direct Support Professionals (DSPs) serve an important role in assisting people with intellectual and developmental disabilities (IDD) in many aspects of their lives through the provision of care and support. Despite lacking in knowledge and training to support the potentially complex and varied presentation of people with IDD, DSPs are in a position to help their clients address and improve on their independent living skills that are important for autonomy and overall well-being. The capstone project developed the Independent Living Skills Teaching Guide (ILSTG), as a tool for DSPs, containing activity plans related to independent living skills, activity modifications based …

Building Bridges: A Community Health Worker Training Course, Taylor A. Ramsey, Lesley Khan-Farooqi, Phd, Otd, Otr, Dr. Sharita Ambrose, Dhed., Mph, Ches, Chwi

Spring 2025 OTD Capstone Symposium

Building Bridges: A Community Health Worker Training Course is a comprehensive 20-hour continuing education course designed for community health workers (CHWS) who work with Black pregnant women. This training course was developed for and in collaboration with Allure Alliance Incorporated, a non-profit organization whose mission is to improve the lives of Black women through community programming, education, and advocacy. This training course reflects an interprofessional collaborative approach to addressing the racial disparities in the Black maternal health population in the U.S. The course includes evidence-based strategies and health management interventions derived from the Occupational Therapy Practice Framework, 4th Edition (OTPF-4), …

Enhancing Concussion Management: Addressing The Needs Of Student-Athletes, Coaches, And Occupational Therapy Practitioners, Anya Vernon, Lesley Khan-Farooqi, Tyra Lea

Spring 2025 OTD Capstone Symposium

There are limited educational resources available on concussion management for occupational therapy practitioners, coaches, and student-athletes which can limit access to comprehensive occupational therapy services for clients who have sustained a concussion, ultimately hindering participation in sport and overall wellbeing. The purpose of this capstone was to develop a comprehensive guidebook for coaches and student-athletes and a comprehensive handbook for occupational therapy practitioners to raise awareness in concussion education and clarify occupational therapy's role on a multidisciplinary concussion management team. This project addresses the growing need for concussion education among student-athletes and coaches, improves understanding of concussion signs and symptoms, …

The Role Of Occupational Therapy In The Care Of Informal Caregivers Of People With Dementia: A Concept Analysis, Ashley M. Taylor, Steven M. Gerardi, Elizabeth Deluca-Berg

Spring 2025 OTD Capstone Symposium

Informal caregivers (care partners) are people, such as family members, who provide care to those who cannot care for themselves, including people with dementia (PwD). Care partners assist PwD in their daily occupations, often without training. Caring for PwD can lead to emotional, physical, financial, and occupational challenges for care partners. Occupational therapy (OT) has a role to play in the care of PwD. However, if clinicians do not operate from a dyadic model, care partners’ needs may be overlooked. Problem: Although addressing the care partner dyad is important to the delivery of OT, the role of OT in the …

Enhancing Psychosocial Well-Being For Pediatric Oncology Clients: A Guidebook For Occupational Therapists, Marzia Khan, Lesley Khan-Farooqi, Brooke Weber

Spring 2025 OTD Capstone Symposium

This capstone project addressed the critical gap in psychosocial support for pediatric oncology clients by developing an evidence-based guidebook for occupational therapy (OT) practitioners. Grounded in the Model of Human Occupation (MOHO), the guidebook provides therapists with developmentally appropriate strategies to enhance emotional regulation, social participation, and engagement in meaningful activities for children aged 3 to 12 undergoing cancer treatment. The project identified key psychosocial challenges through qualitative interviews, needs assessments, and real-time clinical feedback and designed targeted interventions aligned with OT principles. The digital guidebook provides accessible, structured resources to support holistic, client-centered care and improve the quality of …

Optimizing Care For Heart Failure Patients With Reduced Ejection Fraction: A Quality Improvement Project On Guideline Directed Medical Therapy Adherence, Leonie Campbell-Williams

DNP Projects

Significance and Background: Heart failure with reduced ejection fraction (HFrEF) remains a major cause of hospital readmissions, increasing both healthcare utilization and patient morbidity. Guideline-Directed Medical Therapy (GDMT) has been proven to reduce mortality and hospitalizations; however, adherence to these evidence-based guidelines remains inconsistent (Yancy et al., 2022).

Purpose: This quality improvement project aimed to evaluate whether enhancing GDMT adherence in an outpatient heart failure clinic could reduce emergency room (ER) admissions among patients with HFrEF.

Methods: A structured intervention was implemented at a local healthcare system Cardiology Clinic, focusing on optimizing adherence to GDMT in 60 patients with HFrEF. …