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Articles 29191 - 29220 of 325329
Full-Text Articles in Medicine and Health Sciences
All In A Day’S Work: Using Simulation To Prepare Athletic Training Students For Clinical Practice, Matthew Donahue, Hannah L. Stedge
All In A Day’S Work: Using Simulation To Prepare Athletic Training Students For Clinical Practice, Matthew Donahue, Hannah L. Stedge
Internet Journal of Allied Health Sciences and Practice
Purpose: Athletic training educators must prepare students to transition to practice as competent clinicians. Authentic, diverse patient interactions at clinical sites may not occur for all students to prepare them for their career demands. Utilizing simulations in athletic training education may improve students’ transition to practice, but little research has examined interventions to prepare students for a team-based work environment. This paper describes the development process and perceived impact of a student, team-focused athletic training simulation educational technique. Method: This cohort study employed a quasi-experimental research design. A holistic, four-unit athletic training simulation capstone project was designed for final-semester athletic …
Exploring Clinician Understanding Of Therapeutic Alliance, Melissa Cole, Robert Welsh, Susan Shore
Exploring Clinician Understanding Of Therapeutic Alliance, Melissa Cole, Robert Welsh, Susan Shore
Internet Journal of Allied Health Sciences and Practice
Background. Therapeutic alliance is being discussed more readily in allied health literature regarding its potential to improve functional outcomes and patient satisfaction with care. The construct was imported from psychotherapy literature, and the degree and depth of familiarity among practicing physical therapists have not been fully explored. Purpose. This study aims to gain insight into the general level of familiarity and perceptions of therapeutic alliance among practicing clinicians. Methods. A survey was designed to capture a broad professional point of view and distributed using an anonymous link. Results. 73 surveys were completed. 43.3% of respondents reported they were not familiar …
Impact Of Shift Length On Burnout And Job Or Life Satisfaction Among Allied Healthcare Professionals, Tareq F. Alotaibi, Abdulmohsen Altayyar, Muteb Al Muflih, Nawaf Alqahtani, Naif Alhawiti, Badi A. Alotaibi, Sami Al Ossaimi, Hassan Y. Aljohani, Mobarak Alqahtani, Taha Ismaeil, Mohammed Al Qahtani, Saleh Al Garni
Impact Of Shift Length On Burnout And Job Or Life Satisfaction Among Allied Healthcare Professionals, Tareq F. Alotaibi, Abdulmohsen Altayyar, Muteb Al Muflih, Nawaf Alqahtani, Naif Alhawiti, Badi A. Alotaibi, Sami Al Ossaimi, Hassan Y. Aljohani, Mobarak Alqahtani, Taha Ismaeil, Mohammed Al Qahtani, Saleh Al Garni
Internet Journal of Allied Health Sciences and Practice
Abstract: Background/Objectives: Healthcare professionals are critical to community well-being, but the 12-versus 8-hour shifts on their stress and burnout are unclear. This study examines the effects of work patterns on the quality of life, job satisfaction, and burnout among allied healthcare professionals. Method: a validated questionnaire was used. A descriptive analysis, independent samples t-test and Mann–Whitney U test were used, and the significance level was p < 0.05. Results: Among the 340 participants, the mean age was 28 years, and most were women (63.5%), single (58%), and worked 8-hour shifts (54.4%). Most (78%) of the participants reported their job satisfaction …
Crafting Effective Prompts For Chatgpt: A Tutorial, Bonnie Slavych, Greg Williams
Crafting Effective Prompts For Chatgpt: A Tutorial, Bonnie Slavych, Greg Williams
Internet Journal of Allied Health Sciences and Practice
This tutorial explores prompt engineering in artificial intelligence, with a focus on developing effective and efficient prompts for ChatGPT. The content examines the nuances of crafting prompts that are precise and contextually appropriate, offering comparisons between ineffective and effective examples to guide the reader. Through this analysis, readers gain insights into optimizing prompt structure for improved responses from ChatGPT. The tutorial also addresses the ethical considerations and inherent limitations of utilizing AI in professional settings, emphasizing responsible and thoughtful application. By providing practical strategies for prompt engineering, this resource aims to support allied health professionals, educators, and clinicians in integrating …
Comparison Of Cognitive Functions, Sleep Quality, Emotional State, Balance And Physical Activity Levels Of University Students According To Academic Success, Sevim Oksuz, Ozde Depreli, Aytül Ozdil, Gozde Iyigun, Ender Angın, Betül Fatma Bilgin, Ayşen Karaman
Comparison Of Cognitive Functions, Sleep Quality, Emotional State, Balance And Physical Activity Levels Of University Students According To Academic Success, Sevim Oksuz, Ozde Depreli, Aytül Ozdil, Gozde Iyigun, Ender Angın, Betül Fatma Bilgin, Ayşen Karaman
Internet Journal of Allied Health Sciences and Practice
Purpose: This study was planned to compare the level of attention, dual-task abilities, sleep quality, emotional state (anxiety, depression, stress), dynamic balance, and physical activity level in low and high-academic success university students. Method: A total of 134 international undergraduate students between the age of 18 and 25 (low academic success group n=67, high academic success group n=67) were recruited for this study. The Trail Making Test (TMT) – A and B was used for attention assessment, the TMT While Walking – A and B was utilized for dual-task performance, the Pittsburgh Sleep Quality Index (PSQI) was utilized to assess …
Modern Creativity Thriving Through The Roots Of Occupational Therapy, Kelly Allen
Modern Creativity Thriving Through The Roots Of Occupational Therapy, Kelly Allen
The Open Journal of Occupational Therapy
Peace, a client artist at Corvilla, provided the cover art for the Spring 2025 issue of the Open Journal of Occupational Therapy (OJOT). This untitled artwork is a mixed-media painting featuring a vase of daisies, hand-drawn by Peace, which was engraved into reclaimed wood with a CNC machine, painted, and hand-sanded to reveal the image through the contrast of paint and wood. This and many other artworks are produced daily and sold in the storefront of the organization. Corvilla’s art program, Studio Five9, echoes the earliest models of arts and crafts workshops found in rehabilitation facilities in the early 20th …
Empathy In Occupational Therapy: A Call For Reflection, Razan Hamed, Vikram Pagpatan
Empathy In Occupational Therapy: A Call For Reflection, Razan Hamed, Vikram Pagpatan
The Open Journal of Occupational Therapy
Empathy is a building block in health care professions and it has been studied for decades in social and medical sciences given its significant role in health care outcomes and client satisfaction. In a climate where societies are congested with ideological conflicts, sociopolitical issues, racism, microaggressions, and bias, we must reflect on how we are preparing our students and future occupational therapists to be empathetic communicators and clinicians. We must also capture the evolution of empathy in new generations of occupational therapy students in the era of sociopolitical change, telehealth practices, and remote learning. Empathy decline is a documented trend …
Occupational Therapy’S Role In Supporting Persons With Cognitive And Communication Impairment In Acute Hospital Settings, Molly Bathje, Carole Schwartz, Carly Ebert, Allison Harvey
Occupational Therapy’S Role In Supporting Persons With Cognitive And Communication Impairment In Acute Hospital Settings, Molly Bathje, Carole Schwartz, Carly Ebert, Allison Harvey
The Open Journal of Occupational Therapy
It is estimated that 10.9% of adults in the United States live with a cognitive disability and 10% experience communication disorders. When hospitalized, people who have co-occurring cognitive and communication impairments (CCI) experience more hospital-related complications, longer lengths of stay, and higher risks for readmission and mortality. Co-occurring CCI refers to people who are hospitalized for a primary condition who also have a pre-existing or hospital acquired CCI.
Occupational therapists make important contributions to interprofessional care teams for persons with disabilities in hospital settings. This article explores the complexity of individual- and system-level factors contributing to poorer health outcomes for …
Accessibility Status To Pediatric Occupational Therapy Services: Views From Health Care Providers At A Rehabilitation Hospital In Rwanda, Jean Claude Tuyishime, Lizahn Gracia Cloete, Jerome Peter Fredericks
Accessibility Status To Pediatric Occupational Therapy Services: Views From Health Care Providers At A Rehabilitation Hospital In Rwanda, Jean Claude Tuyishime, Lizahn Gracia Cloete, Jerome Peter Fredericks
The Open Journal of Occupational Therapy
Background: Occupational therapy is a growing profession in Rwanda. Since the commencement of the occupational therapy training program at the University of Rwanda in 2014, accessibility to newly established occupational therapy services in Rwanda is unknown. This study aimed to explore health care providers’ views on access to pediatric occupational therapy services at a rehabilitation hospital in Rwanda.
Methods: An exploratory qualitative design with an interpretive descriptive approach was used. Purposive sampling was employed to select a sample of 10 health care providers working at an orthopedic and rehabilitation hospital in Rwanda. The semi-structured interviews were audio-recorded, followed by verbatim …
Personal Narrative As Pedagogy: A Model For Socially Responsive Narrative-Based Education In Occupational Therapy, Johnna Belkiewitz, Sally Wasmuth
Personal Narrative As Pedagogy: A Model For Socially Responsive Narrative-Based Education In Occupational Therapy, Johnna Belkiewitz, Sally Wasmuth
The Open Journal of Occupational Therapy
The practice of occupational therapy relies on the collection and analysis of life narratives to provide responsive client-centered care. As developing holistic practitioners, occupational therapy students are taught to consider these shared stories within a larger context of historical and societal systems by acknowledging such factors as social determinants of health. Case studies are a frequently used tool to teach these skills; however, evidence supports that the identities of these educational stories’ authors can influence which perspectives are shared and, ultimately, impact developing occupational therapists’ perpetuation of or opposition to existing systems of oppression. Critical Race Theory and qualitative methodology …
Exploring The Relationship Between Preadmission Grade Point Average And Selected Occupational Therapy Program Outcomes, Robyn Wu, Jason Straub
Exploring The Relationship Between Preadmission Grade Point Average And Selected Occupational Therapy Program Outcomes, Robyn Wu, Jason Straub
The Open Journal of Occupational Therapy
Grade point averages (GPAs) are often considered in admissions to occupational therapy programs, but the predictive value of GPAs has not been well-studied. The current study investigated if preadmission GPAs predicted whether students passed all occupational therapy program coursework and the National Board for Certification in Occupational Therapy (NBCOT) exam on the first attempt. We analyzed 419 records of students who had matriculated in a master’s or doctoral occupational therapy program between 2010 and 2019. Binary logistic regression analyses were used to determine the effects of the independent variables science GPA and overall GPA on non-passing grades and on NBCOT …
Occupational Therapy’S Role For Gender-Affirming Genital Surgeries: Metoidioplasty And Phalloplasty, Adam Steuer, Kaysen Walker
Occupational Therapy’S Role For Gender-Affirming Genital Surgeries: Metoidioplasty And Phalloplasty, Adam Steuer, Kaysen Walker
The Open Journal of Occupational Therapy
This article explores the new surgical population of gender-affirming surgery, specifically genital surgeries of phalloplasty and metoidioplasty for transgender and gender-diverse people. There are established perioperative rehabilitation guidelines for nearly all other surgeries. A growing population of people is seeking gender-affirming health care that includes genital surgery. This article reviews the guidelines set forth by the World Professional Association for Transgender Health Standards of Care, Version 8, explores the occupational needs of this population, as well as provides suggestions for future versions of the Occupational Therapy Practice Framework, version 4, to provide more inclusive language for the unique needs …
Examining Content Validity Of Home For Life Design Home Assessment For Home Safety And Accessibility, Debra K. Lindstrom, Jade Nguyen
Examining Content Validity Of Home For Life Design Home Assessment For Home Safety And Accessibility, Debra K. Lindstrom, Jade Nguyen
The Open Journal of Occupational Therapy
Background: Older adults aging in place face daily challenges in functional mobility and increased fall risk. Home environments lack accessibility and safety features that promote safety, independence, and longevity. Quality home assessments that are reliable, valid, and efficient are necessary to help determine the safety and accessibility of the built environment for persons aging in place.
Method: A mixed-method study was conducted to determine if the Home for Life Design (HfLD) Home Assessment is a valid assessment for measuring safety and accessibility in the home. Eight experienced occupational therapists completed a Content Validity Index (CVI) and qualitative interview …
Evaluation Of An Occupational Therapy Intervention In Prisons To Prepare Incarcerated Individuals For Successful Community Reentry, Dalenna Bellum, Sue Dahl-Popolizio, R. Curtis Bay, Angela Zhu, Jeremiah Fine, Bruce Kotter, Abbey Glenn, Rebecca L. Wolf
Evaluation Of An Occupational Therapy Intervention In Prisons To Prepare Incarcerated Individuals For Successful Community Reentry, Dalenna Bellum, Sue Dahl-Popolizio, R. Curtis Bay, Angela Zhu, Jeremiah Fine, Bruce Kotter, Abbey Glenn, Rebecca L. Wolf
The Open Journal of Occupational Therapy
Background: Literature suggests that to reduce recidivism and facilitate successful community reintegration, incarcerated individuals need life skills training before release. This study evaluated the effectiveness of such an occupational therapy (OT) program.
Methods: We provided and evaluated a 12-session pilot OT program with incarcerated men providing life skills education for community reentry. We used forced-choice and open-ended questions with pre/post Employee Self-Assessment Tool (ESAT), assessing interpersonal, self-management, analytical skills, and skills used in an organization, and Life Skills Program Daily Surveys (LSDS) assessing participants’ perceptions of program effectiveness.
Results: Ninety-three of the residents participated; 69 completed …
Patient-Generated Graphs To Measure Pain And Fatigue In Persons With Neuralgic Amyotrophy, Renske Mj Janssen, Jos Ijspeert, Jan T. Groothuis, Nens Van Alfen, Alexander Ch Geurts, Maud Jl Graff, Tanya L. Packer, Edith Hc Cup
Patient-Generated Graphs To Measure Pain And Fatigue In Persons With Neuralgic Amyotrophy, Renske Mj Janssen, Jos Ijspeert, Jan T. Groothuis, Nens Van Alfen, Alexander Ch Geurts, Maud Jl Graff, Tanya L. Packer, Edith Hc Cup
The Open Journal of Occupational Therapy
Background: Patients with neuralgic amyotrophy (NA) often experience limitations in daily activities because of pain and fatigue. Visual analogue graphs with a 24-hour x-axis can be used to rate pain and fatigue severity during a typical day. This study aimed to investigate the reliability and validity of the visual analogue graphs in patients with NA.
Method: Eight patients completed pain and fatigue graphs on three moments to examine inter-rater and test-retest reliability using Intraclass Correlation Coefficients (ICCs). Concurrent validity (n = 47) was tested by determining correlations between mean pain graph scores and numerical rating scale for pain (NRS-pain) and …
Influence Of A Disrupted Practice Context On Occupational Therapists' Clinical Reasoning: A Qualitative Study, Perrine Vermeulen, Joseph-Omer Dyer, Marie-Christine Hallé, Marjorie Gingras, Anne Mingant, Manon Parisien, Annie Rochette
Influence Of A Disrupted Practice Context On Occupational Therapists' Clinical Reasoning: A Qualitative Study, Perrine Vermeulen, Joseph-Omer Dyer, Marie-Christine Hallé, Marjorie Gingras, Anne Mingant, Manon Parisien, Annie Rochette
The Open Journal of Occupational Therapy
Background: Clinical reasoning in occupational therapy involves integrating client factors, professional knowledge, and practice context to guide decision-making. The COVID-19 pandemic disrupted health care contexts, potentially affecting therapists' reasoning. This study explored the factors that influenced occupational therapists' clinical reasoning during this crisis.
Method: A qualitative descriptive study was conducted using semi-structured remote interviews with 11 occupational therapists in Quebec, Canada. The 60-min interviews, realized in 2021 and 2022, were recorded, transcribed verbatim, and analyzed inductively to identify reasoning-related themes. Deductive analysis involved coding text segments based on the 14 domains of the Theoretical Domains Framework. Transcripts were coded by …
A Survey-Based Quantification Of Imposter Phenomenon In Occupational Therapy, Dina Prisco, Siobhan Walsh
A Survey-Based Quantification Of Imposter Phenomenon In Occupational Therapy, Dina Prisco, Siobhan Walsh
The Open Journal of Occupational Therapy
Background: Imposter phenomenon is a professional issue that negatively affects health professionals’ performance and well-being. This study examined imposter phenomenon’s prevalence in occupational therapy (OT). Researchers hypothesized that imposter phenomenon is prevalent in OT, more so in underrepresented groups. The rate of imposter phenomenon throughout OT was quantified and rates between demographic groups compared.
Method: This study used an exploratory, survey-based research design. Survey sections included informed consent, demographics, and the Clance Imposter Phenomenon Scale (CIPS). The CIPS measured rates of imposterism. Analyses of variances and independent group t-tests were performed to identify significant differences between groups. Inclusion criteria …
D.A.D.S. Club: Pilot Study Outcomes Of A 5-Week Parenting Program For Fathers In Recovery From Substance Use Disorder, Oaklee Rogers, Kristin Riordan, Elaina Corbin, Shannon Forman, Kara Grace Zahariades, Andrea Clemens, Keely Mcdowell
D.A.D.S. Club: Pilot Study Outcomes Of A 5-Week Parenting Program For Fathers In Recovery From Substance Use Disorder, Oaklee Rogers, Kristin Riordan, Elaina Corbin, Shannon Forman, Kara Grace Zahariades, Andrea Clemens, Keely Mcdowell
The Open Journal of Occupational Therapy
Background: Over 44 million adults have a substance use disorder, with approximately two million children living with a parent with this disorder. Approximately 40% to 60% of men who receive treatment have a child under 18 years of age. However, most parenting programs are developed and implemented for mothers with addiction, leaving fathers without this fundamental knowledge and skills.
Method: A pilot study using a longitudinal interventional study was conducted to explore the feasibility and effectiveness of an occupational therapy-developed program for fathers in recovery. Pre and post surveys, including the Parenting Sense of Competence, were collected from the …
Sensory Processing And Sleep In Infants And Toddlers In Health Provider Shortage Areas - A Cohort Study, Bryan M. Gee, Nicki L. Aubuchon-Endsley
Sensory Processing And Sleep In Infants And Toddlers In Health Provider Shortage Areas - A Cohort Study, Bryan M. Gee, Nicki L. Aubuchon-Endsley
The Open Journal of Occupational Therapy
Background: This study delves into the interplay between sleep quality and sensory processing in infants and toddlers in underserved rural areas in the U.S. Despite established links between these variables in typically developing children, limited research explores this relationship in communities facing elevated rates of mental, behavioral, and developmental disorders.
Methods: We aimed to examine the connections between sensory processing at 10, 14, and 18 months postpartum and sleep quality at 18 months in a rural and medically underserved setting. A total of 44-53 participants completed the questionnaire and survey measures at the specified time points.
Results: Utilizing the Infant …
Perspectives Of School-Based Occupational Therapists, Hannah Smiles, Charlie Mechling, Steven D. Taff, Lauren E. Milton
Perspectives Of School-Based Occupational Therapists, Hannah Smiles, Charlie Mechling, Steven D. Taff, Lauren E. Milton
The Open Journal of Occupational Therapy
Background: In the United States, schools are the second largest employer of occupational therapists (AOTA, 2020a). While research on school-based topics exist, to date there is no comprehensive study on school-based occupational therapy (OT) practice. The purpose of this study was to describe current implementation of the school-based OT process and better understand perspectives of school-based occupational therapists.
Methods: This descriptive study consisted of a researcher-developed survey with open- and close-ended demographic and practical questions related to the school-based OT process. A convenience sample of school-based occupational therapists were recruited with a snowball recruitment strategy via email and …
Guidelines For Conducting Survey Research: Part 2 – Administration And Analysis, Rob Lyerla, Diane Powers Dirette
Guidelines For Conducting Survey Research: Part 2 – Administration And Analysis, Rob Lyerla, Diane Powers Dirette
The Open Journal of Occupational Therapy
In the Fall 2024 issue of The Open Journal of Occupational Therapy (OJOT), the letter from the editor discussed the background of survey research and introduced the readers to a guideline for conducting research with a focus on survey development and recruitment of participants (Dirette & Lyerla, 2024). In this issue, we are following up with Part 2, which focuses on administering a survey and analyzing the results. We hope you find these guidelines useful for conducting quality survey research.
Enhancing Trauma-Informed Care Through The Creation Of Motivational Interviewing Training For Staff Of A Homeless Shelter For Lgbtq+ Young Adults, Olivia R. Ming
OTD Capstone Projects
This doctoral project was completed in collaboration with Nashville Launch Pad (NLP), a nonprofit homeless shelter serving LGBTQ+ young adults and their allies, ages 18–26, in Middle Tennessee. The primary aim of the project was to develop and implement a staff training program that covered several key areas: an introduction to motivational interviewing and its practical application in all 3 NLP settings; an overview of occupational therapy (OT) and its relevance within this setting; the impact of trauma on the body and brain; compassion fatigue; sensory processing differences; and how developmental milestones can be disrupted by trauma, substance use, and …
The Effect Of Kefir Consumption On Gut And Mental Well-Being, Danh Nguyen, Kate Digges, Emerson Morris, Nicole Hinkley-Kellum, Cas Simpson, Dow Mccarty, Erik F. Y. Hom
The Effect Of Kefir Consumption On Gut And Mental Well-Being, Danh Nguyen, Kate Digges, Emerson Morris, Nicole Hinkley-Kellum, Cas Simpson, Dow Mccarty, Erik F. Y. Hom
Neuroscience Research Showcase
(All authors are affiliated with the Department of Biology: Center for Biodiversity and Conservation Research, University of Mississippi)
Members of the Hom Lab are studying the potential benefits of water kefir consumption on Irritable Bowel Syndrome (IBS) symptoms and mental health through Brain-Gut-Microbiota Axis modulation. Water kefir is a probiotic-rich beverage produced by the fermentation of sugar water using symbiotic aggregates of microbes known as water kefir grains (WKGs). WKGs consist of various yeast, lactic acid bacteria, and acetic bacteria bound together through extracellular polysaccharides. Probiotics are defined as foods or supplements that contain live, beneficial microbes that foster well-being …
Voltage-Dependent Anion Channels (Vdacs) Possess A Bh3-Like Domain Capable Of Functionally Complementing The Bh3 Domains Of Bax And Bcl-Xl, Saroj Nepal, Clement Agyemang, Mika Jekabsons, Bradley W. Jones
Voltage-Dependent Anion Channels (Vdacs) Possess A Bh3-Like Domain Capable Of Functionally Complementing The Bh3 Domains Of Bax And Bcl-Xl, Saroj Nepal, Clement Agyemang, Mika Jekabsons, Bradley W. Jones
Neuroscience Research Showcase
(All authors are affiliated with the University of Mississippi)
Abstract: The Bcl-2 protein family plays a critical role in controlling apoptosis through interactions of multidomain pro-apoptotic proteins (e.g., Bax, Bak), anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL, Mcl-1), and BH3-only pro-apoptotic proteins (e.g., Bid, Puma, Noxa). Recent studies have shown that the Voltage-Dependent Anion Channels (VDAC) interact with Bax and Bak to regulate apoptosis. We hypothesize VDACs interact with Bax through their N-terminal region, which we discovered is homologous with the BH3 domains of Bcl-2 family proteins. The results show that the N-terminus of VDACs 1 and 2 can functionally replace the …
Analyzing The Neuroprotective Effects Of Phytoestrogens And Aromatase On Male Zebra Finch Cerebellum Post Lesion, Tony Irovic, Grace Thompson, Lainy B. Day
Analyzing The Neuroprotective Effects Of Phytoestrogens And Aromatase On Male Zebra Finch Cerebellum Post Lesion, Tony Irovic, Grace Thompson, Lainy B. Day
Neuroscience Research Showcase
(All authors are affiliated with Interdisciplinary Studies: Neuroscience, Department of Biology, Interdisciplinary Neuroscience Minor, University of Mississippi)
Introduction:
- Estradiol (E2) & aromatase (AROM) are neuroprotective
- AROM enzymatically converts testosterone (T) into E2
- E2 alters testicular function and increases stroke and cancer risk
- Phytoestrogens, such as genistein (GEN), are plant derived compounds that have a similar chemical structure to E2 and some E2 -like effects
- GEN may possess the neuroprotective effects of E2 while not having the negative effects
- Zebra finch (ZF) brains are highly plastic, and the cerebellum (CB) has low AROM constitutively
- The CB has high levels of estrogen …
A Review Of Recent Studies On The Pathogenesis Of Systemic Sclerosis: Focus On Fibrosis Pathways, Sergio A. Jimenez, Fabian A. Mendoza, Sonsoles Piera-Velazquez
A Review Of Recent Studies On The Pathogenesis Of Systemic Sclerosis: Focus On Fibrosis Pathways, Sergio A. Jimenez, Fabian A. Mendoza, Sonsoles Piera-Velazquez
Scleroderma Center Faculty Papers
Systemic Sclerosis (SSc) is a systemic autoimmune disease of unknown etiology characterized by the development of frequently progressive cutaneous and internal organ fibrosis accompanied by severe vascular alterations. The pathogenesis of SSc is highly complex and, despite extensive investigation, has not been fully elucidated. Numerous studies have suggested that unknown etiologic factors cause multiple alterations in genetically receptive hosts, leading to SSc development and progression. These events may be functionally and pathologically interconnected and include: 1) Structural and functional microvascular and endothelial cell abnormalities; 2) Severe oxidative stress and high reactive oxygen species (3); Frequently progressive cutaneous and visceral fibrosis; …
Zonal Hepatocellular Responses To Acute Ethanol: Impacts On Mitochondrial Function And Metabolism, Matthew T. Savoca
Zonal Hepatocellular Responses To Acute Ethanol: Impacts On Mitochondrial Function And Metabolism, Matthew T. Savoca
MUSC Theses and Dissertations
Background: Ethanol (EtOH) consumption causes hepatocellular mitochondrial depolarization (mtDepo) and mitophagy. Here, the Aims were to develop techniques to characterize sublobular hepatocellular metabolism and the distribution of mtDepo and mitophagy after acute EtOH. Methods: Wildtype and GFP-LC3 transgenic mice were treated with EtOH or vehicle and administered the covalently labeling mitochondrial membrane potential (ΔΨ) reporter, MitoTracker Red (MTR), and/or the non-covalent ΔΨ reporter, rhodamine 123 (Rh123), prior to intravital imaging, liver fixation, or hepatocyte isolation. After in vivo MTR, hepatocytes were isolated and sorted. Enrichment in E-cadherin (ECAD) and cytochrome P4502E1 in periportal (PP) and pericentral (PC) hepatocytes, respectively, validated …
The Effects Of Cyclic Peptide [R4w4] In Combination With First-Line Therapy On The Survival Of Mycobacterium Avium, Melissa Kelley, Kayvan Sasaninia, Ali Badaoui, Ira Glassman, Arbi Abnousian, Nadia Rai, Rakesh K. Tiwari, Vishwanath Venketaraman
The Effects Of Cyclic Peptide [R4w4] In Combination With First-Line Therapy On The Survival Of Mycobacterium Avium, Melissa Kelley, Kayvan Sasaninia, Ali Badaoui, Ira Glassman, Arbi Abnousian, Nadia Rai, Rakesh K. Tiwari, Vishwanath Venketaraman
Pharmacy Faculty Articles and Research
Background: Mycobacterium avium (M. avium) is a nontuberculous mycobacterium (NTM) that can cause pulmonary and extrapulmonary infections mostly in immunocompromised individuals, such as those with HIV and diabetes. Traditionally, rifampicin (RIF) and azithromycin (AZ) have been used for a 12-month duration as first-line antibiotics against M. avium. Due to the increased multidrug resistance, novel ways, such as enhancement of macrophages response, are needed to provide adequate immune response required to clear M. avium infection.
Methods and findings: In this study, we aim to study the effects of using THP-1 cells, which are monocyte-like cells, to induce a …
Evidence-Based Practice Guidelines For Perioperative Insulin Pump Usage And Glycemic Control During The Perioperative Period, Duane Robinson
Evidence-Based Practice Guidelines For Perioperative Insulin Pump Usage And Glycemic Control During The Perioperative Period, Duane Robinson
Doctor of Nursing Practice Scholarly Projects
According to the International Diabetes Federation, Diabetes Mellitus (DM) affects approximately 537 million people, representing approximately 10% of the worldwide population aged 20 to 79. Approximately 400,000 people with DM use continuous subcutaneous insulin infusion (CSII) pumps. CSII pump therapy mimics pancreatic insulin release, aiding in maintaining adequate insulin levels. Individuals with DM are more likely to require surgery than individuals without the disease. Among diabetics, people with Type 1 DM (T1D) are more likely to need medical interventions than individuals with Type 2 DM (T2DM). CSII therapy maintains blood glucose levels within a programmed range and decreases blood glucose …
G-Protein-Coupled Estrogen Receptor 1 And Pregnancy Confer Protection Against Hypertension In Older Females, Ravneet Singh, Supaporn Kulthinee, Victoria L Nasci, Elvis A Akwo, Chibundu Juliet Umunna, Rawan N Almutlaq, Oleh M Pochynyuk, Cassianne Robinson-Cohen, Eman Y Gohar
G-Protein-Coupled Estrogen Receptor 1 And Pregnancy Confer Protection Against Hypertension In Older Females, Ravneet Singh, Supaporn Kulthinee, Victoria L Nasci, Elvis A Akwo, Chibundu Juliet Umunna, Rawan N Almutlaq, Oleh M Pochynyuk, Cassianne Robinson-Cohen, Eman Y Gohar
Faculty, Staff and Student Publications
No abstract provided.