Medicine and Health Sciences Commons^™

Autonomic Recovery Following Post-Exercise Cold Water Immersion, Katherine Gurley

Health Sciences Student Scholarship

Katherine Gurley ’25, Biology and Health Policy Management major

Faculty mentor: Dr. Brett Romano Ely, Health Sciences

The Effects Of Polycystic Ovarian Syndrome (Pcos) On Pregnancy From A Nursing Perspective, Haylee F. Schultz

Honors Capstones

The purpose of this research is to investigate the effects of Polycystic Ovarian Syndrome on pregnancy from a nursing standpoint. Nearly 5-10% of women in the United States are affected by polycystic ovarian syndrome during the reproductive years. This research aims to investigate how this condition impacts fertility and pregnancy risks. This initial research was completed through a review of existing literature accessed through databases such as CINNAHL and PubMed. Once all data is collected, the goal is to seek nursing interventions to lessen the effects of polycystic ovarian syndrome and increase positive pregnancy outcomes. This research is critical as …

Triathlete’S Preferences For Adding Strength Training To Triathlon Training Programming, Brannon Deugan

Doctorate in Kinesiology

This dissertation examined triathletes’ preferences and behaviors related to strength training integration within triathlon training programs, and despite growing evidence supporting the benefits of resistance training for injury prevention and performance enhancement, many endurance athletes remain hesitant to adopt strength training. The purpose of this study was to expand the current understanding of how age, gender, and experience influence strength training decisions and to translate those insights into practical strategies for coaching and athletic programming. A total of 210 triathletes completed an online survey assessing training behaviors, preferred strength modalities, session frequency, and load estimation methods. Quantitative data were analyzed …

Early Assurance Program Outcomes For Matriculation Years 2019-2022, Anita Wilson, Phd, Aaron Douglas, Phd, Alisa Losasso, Md, Katherine Berg, Md, Kathleen Day, Ms, Bonnie Emilius, Ms, Michelle Calderoni, Steven Herrine, Md, Wayne Bond Lau, Charles A. Pohl, Md

JeffMD Academic Affairs

Purpose

The goal of the early assurance admission program is to find and recruit students with an interest in pursuing medicine as a career. Sidney Kimmel Medical College (SKMC) grants three types of early admission to students who meet the eligibility criteria from secondary and post-secondary institutions. This poster compares the performance of early admission students to the performance of a matched sample of traditional admission students.

Analysis Of Skeletal Trauma: Examining Current And Potential, Maia Stevenson

D.U.Quark

Skeletal trauma is an important component of death investigations which is often discovered through postmortem computed tomography (PMCT) scanning. The analysis of skeletal trauma is a key process in the medicolegal field which could provide information on the cause and manner of death of the individual. Though PMCT provides useful imaging data for discovery, there is a lack of reliable technological tools for analyzation of such data. More definitive skeletal reconstruction tools and injury mechanism categorization tools would increase the efficiency of the post-mortem examination process. This review observes the current methods of discovering skeletal trauma through PMCT and surveys …

Supercharged And Delayed Thoracodorsal And Dorsal Intercostal Artery Perforator Flaps For Autologous Breast Reconstruction, Adeem M. Nachabe, Mohammed S. Rais, Mark A. Maier, Hugo St Hilaire, Robert J. Allen

School of Medicine Faculty Publications

In patients seeking total autologous breast reconstruction following mastectomy, prior abdominal surgery can present as a contraindication to utilizing traditional abdominal-based free flaps. The thoracodorsal artery perforator (TDAP) flap has emerged as a suitable alternative, providing adequate tissue and minimal donor site morbidity. This case report demonstrates further improvement to this technique by utilizing the dorsal intercostal artery perforator vessels to supercharge this pedicled flap, along with a surgical delay of the TDAP and dorsal intercostal artery perforator. This adaptation can provide added bulk and improved perfusion to the traditional TDAP-based total autologous breast reconstruction.

Developing Independent Living Skills In People With Intellectual Or Developmental Disabilities: A Guide For Direct Support Professionals, Nigel Yeo Mr.

Student Capstone Papers

Over one percent of the world has intellectual or developmental disabilities (IDD). Many of these people lack the living skills needed to live independently. Direct support professionals (DSPs) are people who provide daily assistance, care, and support to improve the wellbeing and quality of life among people with IDD. DSPs often have minimal training to perform their role, especially in support of the development of independent living skills. Independent living skills are adaptive behavioral competencies related to self-sufficiency, with focus on conceptual skills such as language abilities, social skills including interpersonal and social problem-solving, and practical skills that relate to …

Inhibition Of Soluble Epoxide Hydrolase Confers Neuroprotection And Restores Microglial Homeostasis In A Tauopathy Mouse Model, Shuo Wang, Chuangye Qi, Chetan Rajpurohit, Baijayanti Ghosh, Wen Xiong, Baiping Wang, Yanyan Qi, Sung Hee Hwang, Bruce D Hammock, Hongjie Li, Li Gan, Hui Zheng

Center on Aging Staff Publications

Background: The epoxyeicosatrienoic acids (EETs) are derivatives of the arachidonic acid metabolism with anti-inflammatory activities. However, their efficacy is limited due to the rapid hydrolysis by soluble epoxide hydrolase (sEH). Inhibition of sEH has been shown to stabilize the EETs and reduce neuroinflammation in Aβ mouse models of Alzheimer's disease (AD). However, the role of the sEH-EET signaling pathway in other CNS cell types and neurodegenerative conditions are less understood.

Methods: Here we investigated the mechanisms and functional role of the sEH-EET axis in tauopathy by treating PS19 mice with a small molecule sEH inhibitor TPPU and by crossing the …

Environmental Risk And Alpha-Gal Syndrome (Ags) In The Mid-Atlantic United States, Brandon D. Hollingsworth Ph.D., Margaret Wiener, Dana A. Giandimenico, Scott P. Commins, Ross M. Boyce

Faculty Publications

Alpha-gal syndrome (AGS), commonly referred to as the tick bite red meat allergy, has been reported worldwide with the number of suspected cases in the United States increasing from 24 in 2009 to over 34,000 in 2019. Within the US, AGS is associated with the bite of two tick species, Amblyomma americanum and Ixodes scapularis, and has particularly high incidence rates in the mid-Atlantic region. Because AGS is associated with tick bites, the risk of developing AGS is affected by the environment individuals visit. Despite this, as well as the numerous studies associating the environment with Am. americanum, …

Retroactive Quality Improvement By Utilization Of The Leaf, Preston Stigall

Walden Dissertations and Doctoral Studies

Summary This project is a retroactive quality improvement initiative to evaluate the effectiveness of the LEAF wearable pressure sensor and reduce sacral hospital-acquired pressure injuries (HAPIs) in critically-ill adult patients. The practice problem addressed is the high incidence of pressure injuries in hospitalized patients, which can lead to increased mortality, prolonged hospital stays, and higher healthcare costs. The evidence-based practice question was: In critically ill adult patients at risk of pressure injuries, how does the use of the LEAF wearable pressure sensor compared to standard care without sensors impact the incidence of sacral HAPIs over the past year? The purpose …

Effects Of Hyperglycemia In Cognition And Sex, Erin E. Mcdonald

Senior Honors Theses

An empirical study tested the effects of Type 1 Diabetes (T1D) on cognitive function in a hyperglycemic mouse model. Strong correlations between mental illnesses, such as major depressive disorder, neuropathologies like Alzheimer’s disease, and diabetes suggest comorbid pathology. Considering the prevalence of both T1D and cognitive decline within the general population, the findings were relevant and aimed to identify early signs of cognitive decline in diabetic patients. Behavioral tests and immunohistochemical staining were utilized to determine the cognitive function of the mice, revealing decline or deterioration caused by hyperglycemia. Data gathered from the hyperglycemic or control mice were analyzed based …

Diabetic Retinopathy: A Pathophysiological Discussion, Nathanael C. Nicholls

Senior Honors Theses

Diabetic retinopathy is a severe complication of diabetes that is capable of causing vision loss or blindness. As a result of hyperglycemia, the disease increases oxidative stress and activates biochemical processes such as the Hippo pathway and the complement system to cause significant damage to the retina. Overexpression of BTG1 and microRNA-183 enables activation of biochemical pathways that lead to negative effects on the retinal vascular endothelium including angiogenesis and inflammation. Conventional methods of diagnosis for diabetic retinopathy include fundus examination, nucleoside detection, and optical coherence tomography angiography. Photocoagulation and hormonal intravitreal injection are the most popular current treatments, while …

Volume 16, Maggie Duncan, Madeline Little, Alicia Hoffman, Megan Livesay, Gabrielle Quaresma, Serenity Allen, Laina Pfountz, Ainslie Allred, Sabrina Robles, Nicholas J. Duellman, Trinity L. Deguzman, Melissa H. Savage, Margaret Dudley, Jocelyn Escobar, Olivia Hildreth, Olivia Hopkins, Benjamin Gettier, Lee Kassay, Jade Riddle, Ashley Seiders

Incite: The Journal of Undergraduate Scholarship

Introduction Dr. Amorette Barber, Director, Office of Student Research

From the Editor Dr. Hannah Dudley-Shotwell

Artist’s Statement Maggie Duncan

On Mentoring Dr. Lee Millar Bidwell

The Hujum Campaign in Uzbekistan and its Consequences by Madeline Little

Wet Cupping Compared to Dry Needling for Treatment of Patients with Low Back Pain: A Critically Appraised Topic by Alicia Hoffman and Megan Livesay

Optimization of eDNA Air Sampling Via 3D Printed Fan by Gabrielle Quaresma

Beyond the Classroom: A Qualitative Study of Teacher Attrition and Retention by Serenity Allen and Laina Pfountz

The Treatment of Subacromial Impingement Syndrome with Platelet-Rich plasma Injections Verses …

Covid-19 And The Impact Of Physical Activity On Persistent Symptoms, Lauren E. Opielinski, Toni D. Uhrich, Michael H. Haischer, Rachel N. Beilfuss, Lindsey M. Mirkes Clark, Kamryn M. Kroner, Rachel E. Bollaert, Michael J. Danduran, Linda B. Piacentine, Marie K. Hoeger Bement, Paula E. Papanek, Sandra K. Hunter, Sarah J. Hamilton

Physical Therapy Faculty Research and Publications

Introduction: Physical activity is protective against chronic disease but whether activity is associated with persistent symptoms in non-hospitalized coronavirus disease 2019 (COVID-19) survivors is unknown. The purpose of the study was to determine the impact of the COVID-19 pandemic on physical activity levels and the influence of physical activity on acute COVID-19 and long COVID symptoms in non-hospitalized COVID-19 survivors.

Methods: In total, 64 non-hospitalized COVID-19 survivors (45 female participants, 40 ± 18 years) were assessed for activity levels, body composition, and symptoms of COVID-19 8.5 ± 4.7 months post-infection and categorized into two groups: (1) persistent symptoms and (2) …

Staff Education On The Management Of Diabetes Among Type 2 Diabetic Black American Patients, Ngozi Philomena Anonyuo

Walden Dissertations and Doctoral Studies

The aim of this staff education project was to increase nurses’ knowledge and confidence in providing patient education for diabetes self-management. Insufficient nurse knowledge regarding diabetes care and management was the gap in The practice-focused question was: Among Black American patients, does increasing nurses’ knowledge regarding implementation of diabetes-self management education programs result in a measurable increase in knowledge about diabetes management, ultimately contributing to improved expected diabetic outcomes involving glycemic control and reduced complications? Analytical strategies included descriptive and comparative analysis of deidentified pre- and post-knowledge assessments to evaluate the program’s impact on learning outcomes. An anonymous satisfaction survey …

Impact Of Antidiabetic Medication Type On A New Episode Of Depression: A Retrospective Cohort Study In Texas, Usa, Lin-Na Chou, Mukaila A Raji, Holly M Holmes, Yong-Fang Kuo

Faculty, Staff and Student Publications

Objectives: To examine the associations between antidiabetic medication type and a new episode of depression using 100% Texas Medicare database during 2009 and 2018.

Design: A retrospective cohort study.

Setting: A population-based study using the Texas Medicare data.

Interventions: 11 common antihyperglycaemic medication types, alone and in combinations: metformin-only, five non-metformin-containing regimens (dipeptidyl peptidase-4 inhibitor (DPP4i) only, sulfonylureas (SU) only, thiazolidinediones (TZD) only, SU/DPP4i and SU/TZD) and five metformin-containing combination treatments (metformin/DPP4i, metformin/SU, metformin/TZD, metformin/SU/DPP4i and metformin/SU/TZD).

Participants: This study included 59 057 type 2 diabetes (T2D) patients from a cohort of Texas Medicare beneficiaries who were aged ≥66 years, …

Dual Implants For Geriatric Distal Femur Fractures Results In Greater Healthy Days At Home, Makoa Mau, Tyler Thorne, Cole Payne, Kaleb Roach, Reese Svetgoff, Patrick J Kellam, Graham J Dekeyser, Stephen J Warner, Lucas S Marchand, Justin Haller

Faculty, Staff and Student Publications

Objectives: To compare Healthy Days At Home (HDAH90) within 90 days of hospital discharge after single implant (SI) or dual implant (DI) fixation in geriatric distal femur fractures.

Methods: Design: Retrospective Review.

Setting: Three Level I Trauma Centers.

Patient selection criteria: Geriatric (age ≥ 60 years) distal femur fracture patients (OTA/AO 33 A, C) operatively treated with SI (lateral plate or retrograde intramedullary nail (IMN)) or DI (two plates or plate and IMN) between January 2018-January 2024 were included.

Outcome measures and comparisons: The primary outcome was HDAH90, which was calculated from date of surgery to 90 days follow-up and …

Retrospective Analysis Of Cement Extravasation Rates In Vertebroplasty, Kyphoplasty, And Bone Tumor Radiofrequency Ablation, Soun Sheen, Prit Hasan, Xiaowen Sun, Jian Wang, Claudio Tatsui, Kent Nouri, Saba Javed

Faculty, Staff and Student Publications

Background: Percutaneous vertebral augmentation techniques, including vertebroplasty, kyphoplasty, and bone tumor radiofrequency ablation (BT-RFA), are commonly used to treat painful vertebral compression fractures (VCFs). While generally safe and effective, they carry risks, including cement extravasation, which can lead to pulmonary embolism or spinal cord compression. This study aims to compare the rate of cement extravasation across different vertebral augmentation techniques and identify potential risk factors.

Methods: A retrospective cohort study was conducted at a comprehensive cancer center on 1002 procedure encounters in 888 patients who underwent vertebral augmentation for painful VCFs. Data were collected on patient demographics, fracture pathology, procedure …

Development And Validation Of A Dynamic Real-Time Risk Prediction Model For Intensive Care Units Patients Based On Longitudinal Irregular Data: Multicenter Retrospective Study, Zhuo Zheng, Jiawei Luo, Yingchao Zhu, Lei Du, Lan Lan, Xiaobo Zhou, Xiaoyan Yang, Shixin Huang

Faculty, Staff and Student Publications

Background: Timely and accurate prediction of short-term mortality is critical in intensive care units (ICUs), where patients' conditions change rapidly. Traditional scoring systems, such as the Simplified Acute Physiology Score and Acute Physiology and Chronic Health Evaluation, rely on static variables collected within the first 24 hours of admission and do not account for continuously evolving clinical states. These systems lack real-time adaptability, interpretability, and generalizability. With the increasing availability of high-frequency electronic medical record (EMR) data, machine learning (ML) approaches have emerged as powerful tools to model complex temporal patterns and support dynamic clinical decision-making. However, existing models are …

Inside The Mad Mind: Medical Ethics In 19th Century Fiction, Danielle Dentremont

College Honors Program

The professionalization of medicine in mid-to-late 19th century America and Britain corresponded with heightened critical scrutiny of the ethics of doctor-patient relationships in contemporary fiction. With ethics frameworks of the century focused primarily on good fellowship between practitioners, it was difficult to charge practitioners with bad ethics. Yet, the broader debates of vivisection and women’s rights brought to light power imbalances between men and women that novelists began to suggest were present in medicine as well. Wilkie Collins’ Heart and Science weighs in on the danger of the doctor-scientist encroaching on women’s rights with the suggestion that women will be …

5-Ht Receptors: Pharmacology And Functional Selectivity, Benjamin R. Cummins, Gerald B. Billac, David E. Nichols, Charles D. Nichols

School of Medicine Faculty Publications

Serotonin 5-HT receptors were one of the first serotonin receptors to be pharmacologically characterized. In mammals, they are expressed throughout the body in nearly every cell and tissue type, with the highest density in cortical layer V of the brain. They are involved in several aspects of normal physiological processes and behaviors and have been implicated in the etiology of neuropsychiatric diseases such as schizophrenia. Atypical antipsychotics have targeted blockade of 5-HT receptors as part of their therapeutic mechanism. More recently, 5-HT receptors have come to prominence for their role as the primary target for psychedelic drugs, which activate this …

Is There Evidence For Changes In Antibiotic Resistance Of Microorganisms Causing Postcataract Surgery Endophthalmitis: A Systematic Review, Christina J Flaxel, Justine R Smith, Nieraj Jain, Leo A Kim, Stephen Jae Kim, Maureen G Maguire, Christina Y Weng, Steven Yeh

Faculty, Staff and Students Publications

Background/aims: To review the evidence for changes in antibiotic resistance patterns before and after cataract surgery since the advent of routine use of intracameral (IC) antibiotic prophylaxis and development of newer topical fluoroquinolones pre- and postcataract surgery.

Methods: Literature searches in the National Library of Medicine PubMed database were conducted between 2019 and 2021 and updated in 2024. There were no date restrictions, and the search was limited to high-quality studies published in English. The initial combined searches yielded 583 articles, and the search update in 2024 yielded 9 articles. Of these 592 articles, 26 presented original research that met …

Crossword: Test Your Biology!, Sukie Weinger

Osmosis Magazine

Biology themed Crossword Puzzle.

Intelligence Without An 'I': "I Think, Therefore I Am", Darshan Shah

Osmosis Magazine

From Billie Eilish hits to corny Pinterest tattoos, Rene Descartes’ famous dictum is embedded in modern Western consciousness. But, like all philosophy, it operates within a paradigm of assumptions about the world that remain open to challenge. Over centuries of Cartesian influence, these assumptions have become invisible in our philosophies and sciences, informing the very questions we ask about intelligence and where we search for it in the world.

Zealandan Interview With Dr.Kristine Grayson From Aotearoa New Zealand, Paxton Mills

Osmosis Magazine

ZealandDr. Kristine Grayson, Associate Professor of Biology, has been passionate about science and travel, particularly toAotearoa New Zealand, for some time.

The Undergraduate Research Experience At Ur, Eve Snyder

Osmosis Magazine

toAnyone who has attended the University of Richmond (UR)can attest to the unparalleled experience that is conducting research. Here, the focus is on nurturing well-versed scientists that are capable of critical thinking, deductive reasoning, and problem solving.

Campus As A Living Lab At Ur: What’S Working & What’S Next, Jack Dupuy

Osmosis Magazine

Living labs—real-world experimental environments where diverse stakeholders ranging from local communities and businesses to universities and governments can collaboratively develop, test, and refine solutions—have become an increasingly popular method for tackling complex societal challenges in areas such as energy, urban planning, and environmental sustainability. Unlike controlled laboratory settings, living labs leverage real-world conditions to test innovations in authentic contexts, fostering systemic change by aligning research with local needs.

Droughts, Destruction, And Displacement: How Climate Change Exacerbates Violence In The Sahel, Stevi Dugas

Osmosis Magazine

February 2023 through January 2024 marked the first 12- month period that global average temperatures exceeded the 1.5°C benchmark proposed in the Paris Climate Agreement, indicating early signs of coming dangerously close to exceeding a permanent 1.5°C increase in global average temperatures. Permanently exceeding the 1.5°C benchmark is expected to lead to increasingly frequent and dangerous extreme weather events such as droughts and wildfires, while also increasing the risk of climate tipping points such as collapse of coral reef systems (UN, n.d.). Though no place is safe from the effects of climate change, few places on Earth will be hit …

Monty Hall Problem: Will You Win A Car?, Tien Nguyen Chu

Osmosis Magazine

Suppose you’re on a game show. There are three closed doors. Behind one is a brand-new car; behind the other two, goats. You pick a door. The host, who knows what’s behind all the doors, opens one of the remaining doors to reveal a goat. Now you’re offered a choice: stick with your original door or switch to the other unopened one. What should you do? Will changing your choice increase your chances of winning the car - or or does it make no difference at all?

Myth Or Fact: Does Teethwhitening Really Work?, Garrett Mayover

Osmosis Magazine

Teeth whitening has rapidly gained popularity as one of the most sought-after dental cosmetic procedures today. Once an exclusive treatment performed primarily by dental professionals, it has now expanded into the mainstream market, with store shelves stocked full of “natural” alternatives and “affordable” whitening strips. But the pressing question remains: do these strips actually work, or are they just a marketing gimmick? This article aims to uncover the truth. We will first explorethe science behind teeth whitening and then delve into the effectiveness andpotential drawbacks of these popular over-the-counter products.