Medicine and Health Sciences Commons^™

Clinical Practice Guideline For Wound Care Management In Primary Healthcare Settings Across The British Virgin Islands To Minimize Clinical Practice Variations, Trorisia Shanika John

Walden Dissertations and Doctoral Studies

This quality improvement (QI) initiative in a British Virgin Islands (BVI) primary healthcare setting involved the problem of inconsistent wound care management among registered nurses, which was a concern that was identified in a 2023 audit. The BVI Health Service Authority (HSA)’s diverse nursing staff, which is recruited across the Caribbean, contributed to varied wound care approaches, negatively impacting healthcare delivery and quality. These inconsistencies led to unequal resource access, increased infection and complication risks, and potential financial and legal liabilities. Furthermore, it could negatively affect staff and patient perceptions, potentially decreasing patient satisfaction, highlighting the urgent need for standardized …

Commencement, Philadelphia (2025), Philadelphia College Of Osteopathic Medicine

Commencements

Philadelphia Campus Commencement Program, 2025. Degrees include Doctor of Osteopathic Medicine, Doctor of Philosophy in Educational Psychology, Doctor of Psychology in Clinical Psychology, Doctor of Psychology in School Psychology, Educational Specialist in School Psychology, Master of Science in Applied Behavioral Analysis, Master of Science in Applied Positive Psychology, Master of Science in Mental Health Counseling, Master of Science in Biomedical Sciences, Master of Science in Forensic Medicine, Master of Science in Health Sciences - Physician Assistant Studies.

Commencement Speaker: John J. Lynch III.

The Influence Of Compensation From Wages And Benefits On Healthcare Workers' Performance In Healthcare Services, Jiddan Azizan Hakim, Ghania Danisha Maharani, Riswandy Wasir, Alif Indah Melani, Cahya Arbitera

Journal of Indonesian Health Policy and Administration

This study aims to evaluate the influence of compensation, including wages, incentives, and benefits, on the performance of health workers in primary health centers and hospitals. A literature review was conducted using Google Scholar and PubMed, focusing on articles published in the last 5–10 years. From an initial search yielding 1,021 articles, nine were selected based on inclusion criteria. The results show that direct compensation (salary) and indirect compensation (benefits) have a positive impact on health worker performance. However, the effect of incentives varies depending on implementation. Motivation and job satisfaction were mediating factors that strengthened the relationship between compensation …

Decoding Resistance To Immune Checkpoint Inhibitors In Non-Small Cell Lung Cancer: A Comprehensive Analysis Of Plasma Proteomics And Therapeutic Implications, Michal Harel, Nili Dahan, Coren Lahav, Eyal Jacob, Yehonatan Elon, Igor Puzanov, Ronan J. Kelly, Yuval Shaked, Raya Leibowitz, David P. Carbone, David R. Gandara, Adam P. Dicker

Department of Radiation Oncology Faculty Papers

BACKGROUND: Immune checkpoint inhibitors (ICIs) have shown substantial benefit for patients with advanced non-small cell lung cancer (NSCLC). However, resistance to ICIs remains a major clinical challenge. Here, we perform a comprehensive bioinformatic analysis of plasma proteomic profiles to explore the underlying biology of treatment resistance in NSCLC.

METHODS: The analysis was performed on 388 "resistance-associated proteins" (RAPs) that were previously described as pretreatment plasma proteomic predictors within the PROphet computational model designed to predict ICI clinical benefit in NSCLC. Putative tissue origins of the RAPs were explored using publicly available datasets. Enrichment analyses were performed to investigate RAP-related biological …

Integrative Computational Modeling Of Distinct Binding Mechanisms For Broadly Neutralizing Antibodies Targeting Sars-Cov-2 Spike Omicron Variants: Balance Of Evolutionary And Dynamic Adaptability In Shaping Molecular Determinants Of Immune Escape, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this study, we conducted a comprehensive analysis of the interactions between the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein and four neutralizing antibodies—S309, S304, CYFN1006, and VIR-7229. Using integrative computational modeling that combined all-atom molecular dynamics (MD) simulations, mutational scanning, and MM-GBSA binding free energy calculations, we elucidated the structural, energetic, and dynamic determinants of antibody binding. Our findings reveal distinct dynamic binding mechanisms and evolutionary adaptation driving the broad neutralization effect of these antibodies. We show that S309 targets conserved residues near the ACE2 interface, leveraging synergistic van der Waals and electrostatic interactions, while S304 focuses on …

Current Paradigm And Futuristic Vision On New-Onset Diabetes And Pancreatic Cancer Research, Russell Moreland Iii, Abigail Arredondo, Anupam Dhasmana, Swati Dhasmana, Shabia Shabir, Asfia Siddiqua, Bonny Bannerjee, Murali Yallapu, Stephen Behrman, Subhash Chauhan, Sheema Khan

School of Medicine Publications

New-onset diabetes (NOD) has emerged as a potential early indicator of pancreatic cancer (PC), necessitating a refined clinical approach for risk assessment and early detection. This study discusses critical gaps in understanding the NOD-PC relationship and proposes a multifaceted approach to enhance early detection and risk assessment. We present a comprehensive clinical workflow for evaluating NOD patients, incorporating biomarker discovery, genetic screening, and AI-driven imaging to improve PC risk stratification. While existing models consider metabolic factors, they often overlook germline genetic predispositions that may influence disease development. We propose integrating germline genetic testing to identify individuals carrying pathogenic variants in …

Comprehensive Evaluation Of Phosphoproteomic-Based Kinase Activity Inference, Sophia Müller-Dott, Eric J Jaehnig, Khoi Pham Munchic, Wen Jiang, Tomer M Yaron-Barir, Sara R Savage, Martin Garrido-Rodriguez, Jared L Johnson, Alessandro Lussana, Evangelia Petsalaki, Jonathan T Lei, Aurelien Dugourd, Karsten Krug, Lewis C Cantley, D R Mani, Bing Zhang, Julio Saez-Rodriguez

Faculty, Staff and Students Publications

Kinases regulate cellular processes and are essential for understanding cellular function and disease. To investigate the regulatory state of a kinase, numerous methods have been developed to infer kinase activities from phosphoproteomics data using kinase-substrate libraries. However, few phosphorylation sites can be attributed to an upstream kinase in these libraries, limiting the scope of kinase activity inference. Moreover, inferred activities vary across methods, necessitating evaluation for accurate interpretation. Here, we present benchmarKIN, an R package enabling comprehensive evaluation of kinase activity inference methods. Alongside classical perturbation experiments, benchmarKIN introduces a tumor-based benchmarking approach utilizing multi-omics data to identify highly active …

Predicting Pathologic ≥N2 Disease In Women With Breast Cancer, Kerollos Nashat Wanis, Wenli Dong, Yu Shen, Funda Meric-Bernstam, Taiwo Adesoye, Henry M Kuerer, Abigail S Caudle, Nina Tamirisa, Sarah M Desnyder, Susie X Sun, Isabelle Bedrosian, Puneet Singh, Solange E Cox, Kelly K Hunt, Rosa F Hwang

Faculty, Staff and Student Publications

The distinction between pN1 and ≥pN2 breast cancer impacts treatment decisions. Using data from a single institution on women with cN0 invasive breast cancer who were treated with upfront surgery, had 1-3 positive SLNs, and underwent completion ALND, we used gradient boosted trees (XGBoost) to develop a model for predicting ≥pN2 disease using clinicopathologic variables. Model performance was tested in a held-out subsample (20%) and validated using data from the National Cancer Database (NCDB). Of 3574 patients with cN0 breast cancer, 587 underwent upfront surgery and had 1-3 positive SLNs. Of these, 415 (70.7%) underwent completion ALND, with 64 (15.4%) …

Subcortical Correlates Of Consciousness With Human Single Neuron Recordings, Michael Pereira, Nathan Faivre, Fosco Bernasconi, Nicholas Brandmeir, Jacob E Suffridge, Kaylee Tran, Shuo Wang, Victor Finomore, Peter Konrad, Ali Rezai, Olaf Blanke

2020-Current year OA Pubs

Subcortical brain structures such as the subthalamic nucleus or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness remains unclear, due to the inherent difficulties of recording subcortical neuronal activity in humans. Here, we asked neurological patients undergoing surgery for deep brain stimulation to detect weak vibrotactile stimuli applied on their hand while recording single neuron activity from the tip of a microelectrode. We isolated putative single neurons in the subthalamic nucleus and thalamus. A significant proportion of neurons modulated their activity while participants were expecting a stimulus. We found that the firing …

The Perk/Atf4 Pathway Is Required For Metabolic Reprogramming And Progressive Lung Fibrosis, Jyotsana Pandey, Jennifer L Larson-Casey, Mallikarjun H Patil, Chao He, Nisarat Pinthong, A Brent Carter

Faculty, Staff and Students Publications

Asbestosis is a prototypical type of fibrosis that is progressive and does not resolve. ER stress is increased in multiple cell types that contribute to fibrosis; however, the mechanism(s) by which ER stress in lung macrophages contributes to fibrosis is poorly understood. Here, we show that ER stress resulted in protein kinase RNA-like ER kinase (PERK; Eif2ak3) activation in humans with asbestosis. Similar results were seen in asbestos-injured mice. Mice harboring a conditional deletion of Eif2ak3 were protected from fibrosis. Lung macrophages from asbestosis individuals had evidence of metabolic reprogramming to fatty acid oxidation (FAO). Eif2ak3fl/fl mice had increased oxygen …

A Cross-Sectional Study Of The Role Of Epithelial Cell Injury In Kidney Transplant Outcomes, Philip F. Halloran, Tarek Alhamad, Et Al.

2020-Current year OA Pubs

BACKGROUND: Expression of acute kidney injury-associated (AKI-associated) transcripts in kidney transplants may reflect recent injury and accumulation of epithelial cells in "failed repair" states. We hypothesized that the phenomenon of failed repair could be associated with deterioration and failure in kidney transplants.

METHODS: We defined injury-induced transcriptome states in 4,502 kidney transplant biopsies injury-induced gene sets and classifiers previously developed in transplants.

RESULTS: In principal component analysis (PCA), PC1 correlated with both acute and chronic kidney injury and related inflammation and PC2 with time posttransplant. Positive PC3 was a dimension that correlated with epithelial remodeling pathways and anticorrelated with inflammation. …

It Is Not Clear How Well Physical Activity Promotion Materials Are Understood: Findings From A Rapid Literature Review, Jafra D. Thomas, Jasmine C. Wong, Regina F. Hockert, Yi Sheng Wu, Winston Kennedy

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 6, 2025. Efforts to promote physical activity and other health-related behaviors are more effective when resource materials are understood by a wide and diverse audience. Before our lab’s previous investigations (Thomas et al., 2024), only one study seemed to use the cloze procedure to directly test the comprehension (i.e., readability) of physical activity promotion material (Cardinal & Seidler, 1995). Thus, this rapid literature review sought to (a) determine the extent the cloze procedure has been used to study physical activity promotion material comprehension in lay adults and (b) collate …

Impact Of Transcatheter Aortic Valve Implantation (Tavi) On Left Ventricular Mass, Volumes, And Pressure. A Single-Center Echocardiographic Analysis, Fouad Taiwilaa Alshammari, Afrah Asaad Alonazi, Mohammed Dhaifallah Almutairi, Khaled Ahmed Majrashi, Atheer Mansour Almutairi, Muhammad Azam Shah

Journal of the Saudi Heart Association

Background: Transcatheter aortic valve implantation (TAVI) is an alternative treatment for surgically high-risk patients with severe aortic stenosis (AS). This study aimed to assess the echocardiographic outcomes of TAVI in patients with severe AS, focusing on left ventricular mass, volume, and pressure.

Methods: This retrospective,registry-based, single-center study was conducted at King Salman Heart Center, Riyadh, Saudi Arabia. We included 200 adult patients who underwent the TAVI procedure and completed at least one year of clinical and echocardiographic follow-up. Baseline demographic, clinical, and echocardiographic data were collected and paired pre- and post-procedure echocardiographic measurements were analyzed.

Result: Paired analysis …

Can The Location Of Angina Predict The Site Of Coronary Artery Occlusion In Acute Myocardial Infarction? – The Acolyte Study, Kamal Sharma, Ashwati Konat, Poojan Prajapati, Kavya Darji, Shalin Rawal, Vatsa Bhavsar, Prahar Darji, Yashrajsinh Gohil, Masum Patel, Shubham Patel, Parjanya Bhatt, Yashvi Pethani, Stuti Shah, Hardik Desai

Journal of the Saudi Heart Association

Aim: To evaluate the relationship between the location of chest pain (topography) and the site of coronary artery involvement in patients with acute coronary syndrome (ACS) undergoing percutaneous transluminal coronary angioplasty (PTCA).

Materials and Methods: This prospective, observational study included 411 consecutive ACS patients admitted to a tertiary care center between January 2017 and December 2019. A total of 589 angina topographic sites were analyzed. The site and characteristics of chest pain, along with electrocardiogram and coronary angiography findings, were documented and assessed for correlation with the involved coronary artery.

Results: Among the 411 patients, 337 (82.0%) were male and …

Effect Of Cardiac Rehabilitation Program On Left Ventricular Systolic Function In Patients With Breast Cancer Receiving Anthracycline-Based Chemotherapy Using Two-Dimensional Speckle Tracking Echocardiography, Sarah Mohamed Abdelhady, Ahmed Kadry Araquib, Adel Mohamed Shabana, Adel Gamal Hassanein, Ramy Raymond Elias

Journal of the Saudi Heart Association

Objectives: Anthracyclines used in the treatment of breast cancer are known for their cumulative cardiotoxic effect. Two-dimensional speckle tracking echocardiography is a promising technique in detection of subclinical cardiotoxicity. Cardio-oncology rehabilitation is a new field aiming to decrease the risk of cardiovascular diseases and improve cardiopulmonary fitness among cancer patients

Methods: The study included 100 female patients with de novo breast cancer and treated with anthracycline-based chemotherapy. Patients were randomly assigned into two groups in a 1:1 ratio. Group (1) included patients who were allocated to cardiac rehabilitation program in addition to their regular chemotherapeutic drugs and group 2 …

Artificial Intelligence-Enhanced Ecg For Hypertrophic Cardiomyopathy Diagnosis: A Systematic Review And Meta-Analysis, Fernando (Alonzo) Theja, Louis (Fabio Jonathan) Jusni, Robby Soetedjo, Dimetrio (Alonzo) Theja

Journal of the Saudi Heart Association

Objectives: Diagnosing hypertrophic cardiomyopathy (HCM) can be challenging due to its nonspecific clinical manifestations, variability in electrocardiographic (ECG) patterns, and limited access to echocardiography, the gold standard for diagnosis, often leading to delayed detection. Recent artificial intelligence (AI) advancements have enabled ECG-based algorithms to improve HCM detection. This systematic review and meta-analysis aim to assess the overall diagnostic performance of AI-enhanced ECG in identifying HCM.

Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Articles were retrieved from PubMed, EBSCO, and Proquest. Inclusion criteria encompassed all studies evaluating AI algorithms for the detection of …

Promoting Parent-Child Connectedness: Insights From A Parent Education Training, Bisola E. Duyile, Robyn Becker, Kate Papas, Shanta Pamphile

Journal of Interprofessional Practice and Collaboration

Purpose: This study explores the interrelationship of speech, language, and literacy development, parent-child connectedness, and children’s mental health when viewed as social determinants of health, specifically among families of children with developmental disabilities. Through interprofessional collaboration, researchers aim to identify effective strategies that parents can use to enhance their children’s communication skills and emotional well-being.

Methods: A mixed methods design was employed, involving a post-workshop survey completed by five mothers. The quantitative component included Likert scale items to measure satisfaction with social support. We also evaluated satisfaction with the workshop. The qualitative component comprised open-ended questions about newly learned tools …

Impact Of Interprofessional Instructional Design On Graduate Healthcare Students Collaborative Practice Competency, Karene Boos, Barbra Beck, Jamie Krzykowski, April M. Doebert-Fischer

Journal of Interprofessional Practice and Collaboration

Purpose This study examines the impact of three delivery models of an interprofessional education (IPE) curriculum on perceptions of interprofessional collaborative practice competencies among graduate-level health profession students. The curriculum was rooted in the Interprofessional Education Collaborative (IPEC) Core Competencies (2016).

Problem Statement Despite widespread recognition of the importance of IPE in preparing healthcare students for collaborative training by numerous health organizations, health profession programs, and their accrediting agencies, there is no clear pedagogical best practice for training students from various health professions to achieve effective interprofessional training.

Significance IPE is essential for fostering skills in interprofessional collaboration, a critical …

Enhancing Interprofessional Collaboration Among Rehabilitation Professionals For Spinal Cord Injury Care In Pakistan, Shala Cunningham, Martina Lukin, Neelum Zehra, Rachael Lowe, Abdulgafoor Bachani

Journal of Interprofessional Practice and Collaboration

Purpose

The purpose of this study was to explore the effectiveness of a course series for the rehabilitation of patients with spinal cord injury (SCI) on participants’ perceptions of interprofessional collaboration and teamwork.

Problem

In Pakistan, the prevalence of SCI has surged, highlighting the need for coordinated rehabilitation services. However, individuals with SCI in Pakistan often receive little to no rehabilitation after their injury, which negatively impacts their recovery outcomes. Furthermore, the understanding of collaborative education and practice appears to be limited within health organizations in Pakistan.

Significance

This study highlights the effectiveness of an interdisciplinary education program in improving …

An Innovative Constraint-Induced Movement Therapy (Cimt) Program Design And Case Study To Address Upper Extremity Use And Spatial Inattention, Mark Blanchard, Ingrid A. Franc, Payton Nisby, Michelle Arceneaux, Kathleen Chapiesky, Genevieve Ducros, Austin Brannon

Journal of Interprofessional Practice and Collaboration

Introduction: Common consequences of stroke include decreased upper extremity function and spatial inattention, both of which cause difficulties in occupational performance in activities of daily living. Constraint-Induced Movement Therapy (CIMT) is an intervention that has been utilized to improve these consequences of stroke.

Methods: This single case study describes the design and results of a two-week modified CIMT (mCIMT) program that used an enhanced visual and auditory feedback system, the Flint Rehab FitMi device, to address both upper extremity function and left spatial inattention in one participant. Left spatial awareness was encouraged during mCIMT activities by striking targeted pucks placed …

Interprofessional Collaboration Between Primary Care And Occupational Therapy, Ellen Modlin, Phd, Otr/L, Bcp, Caps, Deana Shevit Goldin, Phd, Dnp, Arnp, Fnp-Bc

Journal of Interprofessional Practice and Collaboration

Purpose: This article explores the utilization of occupational therapy (OT) in interprofessional health care teams in adult populations. Primary care settings are typically the first point of contact for individuals seeking health care services; therefore, primary care practitioners (PCPs) are in a unique position to initiate collaboration with specialty clinicians to optimize the use of health care resources.

Method: Peer- reviewed literature from primary care and OT research was reviewed and summarized. The search focused on barriers and potential opportunities for collaboration between primary care and occupational therapy in adult populations.

Results: Occupational therapy (OT) is underutilized, as lack of …

The Role Of Social Media In Higher Education For Recruitment And Retention And The Implications For Nursing Programs, Cari Granier, Jamie Gravois

Journal of Interprofessional Practice and Collaboration

Abstract:

Purpose: This review article assesses findings related to social media use in regards to student recruitment and retention for higher education institutions (HEIs) including schools of nursing. This review outlines the need for building a social media presence, creating engaging content for target audiences, available platforms, and posting times and frequency. Methods: A literature review was conducted with keywords including the following terms in combination with “social media and” higher education marketing, higher education recruitment, university marketing, university recruitment, college marketing, and college recruitment. Results: College applicants rely on social media when making decisions about …

Promoting Student Engagement In Interprofessional Education To Advance Institution-Based Research, Curriculum Development, And Practice Interventions, Natalya Salganik, Nicole Trupiano, Vani Patterson, Rajesh Mangrulkar

Journal of Interprofessional Practice and Collaboration

Promoting Student Engagement in Interprofessional Education to Advance Institution-Based Research, Curriculum Development, and Practice Interventions

Abstract

Background

The Michigan Center for IPE (C-IPE) Student Advisory Committee (SAC) is a student-run committee that serves as a collaborative student community among health professional schools at our institution. Since its creation in 2018, SAC identified a need for students to take a lead in improving the interprofessional education (IPE) experience at the University of Michigan in collaboration with the C-IPE.

Methods

Together with the C-IPE, SAC focused on three tasks to achieve its goals: (1) increasing student engagement in IPE, (2) increasing transparency …

Enhancing Physical Therapy Practice Through Interprofessional Collaboration: Addressing Elderly Self-Neglect Via Pt And Behavioral Health Integration, Alexia Stamas, Feroze Sio, Jodi Thomasian, Kate Jansen, Margaret R. Klausing

Journal of Interprofessional Practice and Collaboration

Purpose: This article examines the role of interprofessional collaboration between Physical Therapy (PT) and Behavioral Health (BH) services in identifying and supporting elderly individuals at risk of self-neglect. Through a case study, we explore the benefits of integrating interprofessional collaboration and APS reporting processes into PT practice.

Problem: Self-neglect among older adults is a critical public health issue often overlooked in healthcare settings. PTs, as mandated reporters, frequently encounter patients exhibiting signs of self-neglect but may lack training in psychosocial and cognitive assessment skills necessary for effective intervention.

Significance: Interprofessional collaboration enables PTs to address both physical …

Do Repeating Interprofessional (Ip) Courses Stimulate To Increased Development Of Ip Competencies?, Anders Baerheim, Ingunn Johanne Ness, Reidun Lisbeth Skeide Kjome, Merethe Hustoft, Sissel Johansson Brenna, Ane Johannessen

Journal of Interprofessional Practice and Collaboration

The aim of this study was to elucidate whether acquired interprofessional (IP) competencies increased with repeated IP courses. Methods. We used a cross-sectional survey including students from four IP courses at two Norwegian higher educational institutions. One site had a 1-2 weeks on-campus training for their bachelor students at the start of each of the three academic years, whilst the other site arranged a workplace-based course for final year health and social care students from both educational institutions. Students from the first site complete all three on-campus courses and the workplace-based course before completion of their education, while students …

2025 May 20 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Characterization Of Immunogenicity Of Hiv Mrna Vaccine In Humanized Mice, Omoyeni Precious Adejare

Biotechnology Theses

Human Immunodeficiency Virus (HIV) remains a leading global cause of mortality. Despite decades of research, a definitive cure or an effective vaccine for HIV infection has yet to be discovered. The major target for HIV vaccine development is the envelope (Env) trimeric protein that is responsible for host cell attachment and fusion. This comprises gp120 and the transmembrane gp41. Gp140, a truncated form of gp160(full envelope trimer) lacks the transmembrane and cytoplasmic domains of gp41, closely mimics the native HIV envelope has been shown to enhance the induction of broadly neutralizing antibodies (BnAbs) when used as protein vaccine in previous …

Various Bone Disorders Affecting The Medically Underserved South Texas Region, Blake Martin, Manoj Peiris, Michael Sander

School of Medicine Publications

Bone disorders can have a devastating impact on an individual’s quality of life. The main objective of our study was to analyze various demographic disparities between various bone disorders in the demographically unique Rio Grande Valley region. We hypothesized that osteoporosis would be the most prevalent condition and that the demographics between the various conditions would vary depending on age, sex, BMI, and ethnicity but not on marital status. This was a retrospective chart review using the University of Texas Rio Grande Valley UTHealth electronic database from January 1, 2017, to January 1, 2024. Any relevant individuals seen at a …

From M. Chelonae To M. Immunogenum: A Rare Case Of Dual Nontuberculous Mycobacterial Infection, Ifeanyi Kingsley Uche, Nathalia Simonetti, Andrea Murina

School of Medicine Faculty Publications

No abstract provided.

Optimizing Warfarin Management In Cardiovascular Care, Tessa A. Martinez

Doctor of Nursing Practice Final Manuscripts

Background: Maintaining a therapeutic International Normalized Ratio (INR) is essential to reduce bleeding and thromboembolic risks in patients on warfarin therapy. In a rural outpatient cardiac clinic serving a predominantly underserved population, many patients face financial and access barriers that preclude the use of newer non-vitamin K antagonist oral anticoagulants (NOACs). Patients with atrial fibrillation (AF) or mechanical valve replacements who rely on warfarin require consistent monitoring and management, which can be challenging in settings with limited resources and staffing.

Purpose: The purpose of this evidence-based pilot project was to improve therapeutic INR outcomes through the implementation of a standardized …