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Full-Text Articles in Medicine and Health Sciences

Authentication Of Kaffir Lime Leaf Oil (Citrus Hystrix D.C.) In Products Using Ftir Combined With Chemometrics, Jeffry Jeffry, Any Guntarti, Nina Salamah Jul 2025

Authentication Of Kaffir Lime Leaf Oil (Citrus Hystrix D.C.) In Products Using Ftir Combined With Chemometrics, Jeffry Jeffry, Any Guntarti, Nina Salamah

Pharmaceutical Sciences and Research

Indonesia is rich in aromatic plants, producing approximately 40 types of essential oils used in various industries, including health and aromatherapy. Essential oils have significant potential but face high rates of adulteration. This study aimed to identify kaffir lime leaf oil (Citrus hystrix D.C.), to determine the essential oil profile, and to detect adulteration in commercial oil products. The methods used involved steam distillation and characterization tests of kaffir lime leaf essential oil, including yield percentage and organoleptic, density, refractive index, and solubility in alcohol. An essential oil content test and adulteration detection using FTIR combined with chemometrics were …


Implications Of Palliative Care Education Amongst Critical Care Nurses And Applicable Screening Criteria For Consultation, Paiten Rask Jul 2025

Implications Of Palliative Care Education Amongst Critical Care Nurses And Applicable Screening Criteria For Consultation, Paiten Rask

DNP Projects

Background:
Palliative care is underutilized and/or consulted too late in the patient stay to provide optimal benefits to patients and families. There is a gap in nursing knowledge and confidence surrounding the topic of palliative care and the ability to advocate for specialty involvement for patients.

Objectives:
This project's purpose is to educate registered nurses in critical care about palliative care and introduce the idea of an objective palliative care screening tool. The project involved implementation of pre and post-test analysis of knowledge and confidence following a presentation of educational content. The content also included mock patient scenarios that require …


Implementing A Standardized Education Program To Enhance Nurses' Utilization Of Virtual Nurse Support, Emma Steck Jul 2025

Implementing A Standardized Education Program To Enhance Nurses' Utilization Of Virtual Nurse Support, Emma Steck

DNP Projects

The rapid expansion of telehealth and virtual nursing support necessitates the development of standardized education programs to optimize the utilization of virtual support systems. This quality improvement project aimed to address the problem of inconsistent and outdated orientation methods for hospital nurses working with virtual registered nurse (ViRN) support staff at a large Midwest hospital. The project engaged over 800 nursing staff across more than 30 inpatient care units, with a focused pilot conducted on three intervention units. The intervention involved the development of an online learning module designed to standardize training and improve utilization of ViRN support. Utilizing the …


Effects Of Liver Surgery On Drug Transporters In The Liver And Remote Organs, Reza Mehvar Jul 2025

Effects Of Liver Surgery On Drug Transporters In The Liver And Remote Organs, Reza Mehvar

Pharmacy Faculty Articles and Research

Alterations in drug transporters in acute liver failure and chronic liver diseases, such as cirrhosis, have been reviewed before. However, there is a lack of comprehensive reviews on how liver surgery, including transplantation and partial hepatectomy, affects drug transporters. Because ischemia–reperfusion (IR) injury is a hallmark of liver transplantation and most other surgical procedures of the liver, this review focuses on the effects of IR injury, in addition to liver resection, on the expression and function of transporters in the liver and remote organs. Most of the reported studies in this area are carried out in animal models of liver …


Unmasking The Heart Of Osimertinib: A Closer Look At Drug-Induced Cardiotoxicity, Muhammad Sabri, Aheed Javaid, Hussam Al Hennawi, Hamza Muhammadzai, Vamshi Mallavarapu Jul 2025

Unmasking The Heart Of Osimertinib: A Closer Look At Drug-Induced Cardiotoxicity, Muhammad Sabri, Aheed Javaid, Hussam Al Hennawi, Hamza Muhammadzai, Vamshi Mallavarapu

Abington Jefferson Health Papers

BACKGROUND: Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is an effective therapy for epidermal growth factor receptor-mutated non-small cell lung cancer, but it has been associated with a higher incidence of cardiotoxicity.

CASE SUMMARY: A 91-year-old woman on osimertinib 80 mg daily presented with acute dyspnea and was found to have a newly reduced left ventricular ejection fraction of 30%. Coronary angiography excluded obstructive coronary disease. Osimertinib was discontinued, and guideline-directed medical therapy (GDMT) was initiated, resulting in left ventricular ejection fraction recovery to 60%. The patient was successfully rechallenged with osimertinib while continuing GDMT, without recurrence …


Método Para La Enseñanza Del Cuidado En Enfermería. Competencia En Práctica Basada En La Evidencia, Adriana Hernández Bustos, María Victoria Rojas Martínez Jul 2025

Método Para La Enseñanza Del Cuidado En Enfermería. Competencia En Práctica Basada En La Evidencia, Adriana Hernández Bustos, María Victoria Rojas Martínez

Ciencias de la Salud

Método para la enseñanza del cuidado en enfermería. Competencia en práctica basada en la evidencia es un libro resultado de un proyecto de investigación multicéntrico desarrollado en Colombia, cuyo objetivo fue analizar el nivel de conocimiento, actitudes y habilidades sobre la Práctica Basada en la Evidencia (PBE) en estudiantes de programas de Enfermería de diferentes regiones del país. Esta obra colectiva surge en respuesta a la necesidad de consolidar la formación en competencias PBE desde el pregrado, reconociendo que el ejercicio profesional en enfermería debe estar fundamentado en el uso sistemático y crítico de la evidencia científica, en armonía con …


Assessment Of Total Cardiovascular Risk Using Who/Ish Risk Prediction Chart Among Adults In Rural Areas Of Mysuru: A Cross-Sectional Study, Anchu R Nath, Amogha Shree, Rashmi S, Shweta N K, Deepshika R, Sunil Kumar D Jul 2025

Assessment Of Total Cardiovascular Risk Using Who/Ish Risk Prediction Chart Among Adults In Rural Areas Of Mysuru: A Cross-Sectional Study, Anchu R Nath, Amogha Shree, Rashmi S, Shweta N K, Deepshika R, Sunil Kumar D

Digital Journal of Clinical Medicine

Background:

Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality in rural India, where preventive healthcare infrastructure remains underdeveloped. Myocardial infarction and stroke are among the deadly events that are caused by a combination of risk factors that are present in the majority of cardiovascular diseases (CVD). This study aimed to estimate the 10-year CVD risk among adults in rural Mysuru using the WHO/ISH risk prediction charts, a practical tool designed for low-resource settings.

Methodology:

This community-based cross-sectional study was conducted over three months (January 2025- March 2025), involving 172 study participants from the rural field practice area …


Staff Education On Culturally Tailored Hispanic Diabetes Management In A Primary Care Community Clinic, Robyn Elizabeth Reeves Jul 2025

Staff Education On Culturally Tailored Hispanic Diabetes Management In A Primary Care Community Clinic, Robyn Elizabeth Reeves

Walden Dissertations and Doctoral Studies

The Hispanic population is the fastest-growing ethnic minority in the United States, and they have a 66% chance of developing Type 2 diabetes mellitus (T2DM). Less than half of Hispanic patients with diabetes achieve optimal glycemic control due to cultural barriers and dietary issues. At the project site, a primary care practice in the southeastern United States regarding cultural competency training in diabetes management for Hispanics was identified. The practice-focused question was: Does providing education to primary care staff improve their knowledge of diabetes management among Hispanic patients with diabetes, as evidenced by pre- and post-surveys? In the project, I …


Ctnna3 Deficiency Promotes Heart Regeneration By Enhancing Cardiomyocyte Proliferation In Neonatal Mice, Sha Zou, Wuhou Dai, Wufan Tao, Jifen Li, Zeyi Cheng, Hongyan Wang Jul 2025

Ctnna3 Deficiency Promotes Heart Regeneration By Enhancing Cardiomyocyte Proliferation In Neonatal Mice, Sha Zou, Wuhou Dai, Wufan Tao, Jifen Li, Zeyi Cheng, Hongyan Wang

Department of Medicine Faculty Papers

Background: Heart regeneration requires renewal of lost cardiomyocytes. However, the mammalian heart loses its proliferative capacity soon after birth, and the molecular signaling underlying the loss of cardiac proliferation postnatally is not fully understood.

Purpose: This study aimed to investigate the role of Catenin alpha 3 (Ctnna3), coding for alpha T catenin (αT-catenin) protein in regulating cardiomyocyte proliferation and heart regeneration during the neonatal period.

Methods: Here we report that ablation of Ctnna3 and highly expressed in hearts, accelerated heart regeneration following heart apex resection in neonatal mice.

Results: Our results show that Ctnna3 deficiency enhances cardiomyocyte proliferation …


The Processes That Contribute To Readiness To Learn For An Accelerated Nursing Graduate: A Grounded Theory Study, Kaye A.L. Whyte Jul 2025

The Processes That Contribute To Readiness To Learn For An Accelerated Nursing Graduate: A Grounded Theory Study, Kaye A.L. Whyte

Theses & Dissertations

The worldwide nursing shortage has led to maintaining an adequate nursing workforce as a global challenge. Increased recruitment efforts have fostered changes to some educational programs, giving rise to the proliferation of Accelerated Nursing Programs (ACCEL). These accelerated nursing programs are a highly successful way of educating future registered nurses, leading to concerns by registered nurses, hospital administrators, and nursing faculty who question the transitional competence of graduates from Accelerated Nursing Programs. The purpose of this study was to understand the transition processes for accelerated nursing graduates. The intended impact of this research was important to nursing for two reasons: …


In Vitro Α-Glucosidase Enzyme Inhibition Activity Test Of Water Extract From Sintok (Cinnamomum Sintoc Blume) Bark, Astrella Amanda Putri Saksono, Inana Ratu Soripada Simanjuntak, Mariana Wahjudi, Marisca Evalina Gondokesumo Jul 2025

In Vitro Α-Glucosidase Enzyme Inhibition Activity Test Of Water Extract From Sintok (Cinnamomum Sintoc Blume) Bark, Astrella Amanda Putri Saksono, Inana Ratu Soripada Simanjuntak, Mariana Wahjudi, Marisca Evalina Gondokesumo

Pharmaceutical Sciences and Research

Diabetes mellitus is a condition characterized by elevated blood glucose levels beyond the normal limits. One therapeutic approach for managing diabetes mellitus involves inhibiting the α-glucosidase enzyme, which plays a role in glucose absorption in the body. However, the use of oral antidiabetic drugs from the α-glucosidase inhibitor class often causes gastrointestinal side effects. Therefore, exploring natural materials as alternative treatments is a promising option. In Indonesia, one plant with potential as an alternative treatment is sintok (Cinnamomum sintoc Blume), a member of the Cinnamomum genus, which is widely utilized in traditional medicine for chronic diseases such as …


Gastroprotective Potential Of Medicinal Plant From Central Kalimantan: Sungkai Leaves (Peronema Canescens Jack)-Ultrasonic Assisted Extraction In Rats Induced With Absolute Ethanol, Dilasari Savitri, Elsa Trinovita, Ratna Widayati, Septi Handayani, Sintha Nugrahini Jul 2025

Gastroprotective Potential Of Medicinal Plant From Central Kalimantan: Sungkai Leaves (Peronema Canescens Jack)-Ultrasonic Assisted Extraction In Rats Induced With Absolute Ethanol, Dilasari Savitri, Elsa Trinovita, Ratna Widayati, Septi Handayani, Sintha Nugrahini

Pharmaceutical Sciences and Research

Peptic ulcer disease is a gastrointestinal disorder associated with significant morbidity and mortality. Enhancing the quality of life of patients with peptic ulcers often involves integrating conventional treatments with complementary alternative therapies. One such alternative therapy is herbal remedies, which local communities have long recognized. Sungkai leaves (Peronema canescens Jack) contain various bioactive components, including flavonoids, alkaloids, saponins, tannins, steroids, and phenolic compounds. This study aimed to assess the gastroprotective properties of sungkai leaf extract (Peronema canescens Jack) by analyzing the average size of gastric lesions in male Wistar rats exposed to absolute ethanol. The research used a …


A Workplace Posture Initiative To Reduce Work-Related Musculoskeletal Disorders, Carrie Isaac Jul 2025

A Workplace Posture Initiative To Reduce Work-Related Musculoskeletal Disorders, Carrie Isaac

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Work-related musculoskeletal disorders (WRMSDs) are a leading cause of occupational injury and discomfort in industrial workplaces. Although an ergonomic program existed at the project site, a formalized process to detect postural misalignments early had not been established. Relying on employee self-reporting, delayed intervention, and limited opportunities to prevent injuries before they progress.

Aim of the Project: A proactive posture screening program using PostureScreen® was implemented to identify postural deviations that could contribute to WRMSDs. Emphasis was placed on supporting employees through early awareness of posture-related issues and evaluation of alignment improvements following individualized intervention.

Review of the Evidence: Evidence …


"Comparative Evaluation Of Breast Radiation Treatment Planning: Volumetric Modulated Arc Therapy (Vmat) Versus Modern Advanced 3d Planning Techniques (Ma-3drt) —Benefits, Limitations, And Clinical Implications", Christopher Kyle Sears Jul 2025

"Comparative Evaluation Of Breast Radiation Treatment Planning: Volumetric Modulated Arc Therapy (Vmat) Versus Modern Advanced 3d Planning Techniques (Ma-3drt) —Benefits, Limitations, And Clinical Implications", Christopher Kyle Sears

Masters Projects

Abstract 2 Left-sided breast cancer poses significant cardiac and pulmonary risks during radiation therapy, requiring techniques that optimize target coverage while minimizing exposure to critical organs. This study aimed to compare Volumetric Modulated Arc Therapy (VMAT) and Modern Advanced 3D Radiation Therapy (MA-3DRT), specifically Radformation’s EZFluence, in the treatment of left-sided breast cancer with nodal involvement. The objective was to evaluate which technique offers superior organ-at-risk (OAR) sparing, improved target coverage, and practical efficiency for clinical implementation. A retrospective dosimetric analysis was conducted on eight patients, each with an existing MA-3DRT plan. VMAT plans were generated using identical CT simulation …


Dosimetric Comparisons Of 6mv, 6fff, 10mv, And 10fff On Vmat Planning In Patients With Endometrial Cancer, Madisin M. Depas Jul 2025

Dosimetric Comparisons Of 6mv, 6fff, 10mv, And 10fff On Vmat Planning In Patients With Endometrial Cancer, Madisin M. Depas

Masters Projects

Purpose: This study aimed to evaluate the dosimetric and efficiency impacts of different photon beam energies—6MV, 6 flattening filter free (FFF), 10MV, and 10FFF—on volumetric modulated arc therapy (VMAT) plans for endometrial cancer, with attention to target coverage, organ at risk (OAR) sparing, and treatment efficiency.

Methods: A retrospective analysis was conducted on 25 patients with post-hysterectomy endometrial cancer. Each patient received four VMAT plans with varying energies. Planning metrics assessed included planning target volume (PTV) dose maximum (Dmax), conformity index (CI), heterogeneity index (HI), OAR doses (bladder, bowel, rectum), and total monitor units (MU). Correlations were drawn …


Retrotransposon Methylation Profiles And Survival In Black Women With High-Grade Serous Ovarian Carcinoma, Christelle Colin-Leitzinger, Katherine A Lawson-Michod, Courtney E Johnson, Irma M Vlasac, Sean Yoder, Dana Roeber, Michelle A T Hildebrandt, Kristin Haller, Anthony J Alberg, Elisa V Bandera, Melissa Bondy, Michele L Cote, Theresa Hastert, Edward S Peters, Paul D Terry, Andrew B Lawson, Andrew Berchuck, Brooke L Fridley, Jing-Yi Chern, Jennifer A Doherty, Jeffrey R Marks, Joellen M Schildkraut, Brock C Christensen, Lucas A Salas, Lauren C Peres Jul 2025

Retrotransposon Methylation Profiles And Survival In Black Women With High-Grade Serous Ovarian Carcinoma, Christelle Colin-Leitzinger, Katherine A Lawson-Michod, Courtney E Johnson, Irma M Vlasac, Sean Yoder, Dana Roeber, Michelle A T Hildebrandt, Kristin Haller, Anthony J Alberg, Elisa V Bandera, Melissa Bondy, Michele L Cote, Theresa Hastert, Edward S Peters, Paul D Terry, Andrew B Lawson, Andrew Berchuck, Brooke L Fridley, Jing-Yi Chern, Jennifer A Doherty, Jeffrey R Marks, Joellen M Schildkraut, Brock C Christensen, Lucas A Salas, Lauren C Peres

Faculty, Staff and Student Publications

Introduction: Retrotransposons (REs) constitute nearly half of the genome and include long terminal repeat (LTR) elements, Long INterspersed Elements (LINE), and Short INterspersed Elements (SINE). REs are typically silenced in somatic tissues via DNA methylation but can be reactivated through DNA hypomethylation, potentially impacting gene regulation. Here, we investigate genome-scale profiles of RE methylation in high-grade serous ovarian carcinoma (HGSOC) and associations with survival among Black women.

Methods: Methylation levels of LTR, LINE-1, and Alu (type of SINE) in 200 HGSOC tumors were predicted using a random forest approach and clustered using multiple consensus algorithms. Associations between RE methylation clusters …


Precision Medicine And Beyond: Evolving Roles Of Targeted Therapy, Immunotherapy, And Artificial Intelligence In Oncology, Linwei Li, Anika Doppalapudi, Jennifer Escamilla, Annu Karithara, Christine Pham, Angel Phillip, Sriya Gullapalli, Lois Baldado, Arjun Bellamkonda, Daniela Gonzalez, Amin Ibrahim, David Sta. Maria, Kaitlyn Ybanez, Hugo Zamarron, Shizue Mito Jul 2025

Precision Medicine And Beyond: Evolving Roles Of Targeted Therapy, Immunotherapy, And Artificial Intelligence In Oncology, Linwei Li, Anika Doppalapudi, Jennifer Escamilla, Annu Karithara, Christine Pham, Angel Phillip, Sriya Gullapalli, Lois Baldado, Arjun Bellamkonda, Daniela Gonzalez, Amin Ibrahim, David Sta. Maria, Kaitlyn Ybanez, Hugo Zamarron, Shizue Mito

School of Medicine Publications

Precision medicine in oncology is an evolving therapeutic approach that leverages genetic, clinical, and biomarker data to tailor treatments to individual patients. This review explores the three core pillars of modern precision oncology: targeted therapy, immunotherapy, and the integration of artificial intelligence (AI) into clinical practice. Targeted therapies, including monoclonal antibodies and antibody-drug conjugates, selectively inhibit molecular pathways involved in tumor growth. While conventional chemotherapy remains the backbone of treatment and has improved remission rates, its cytotoxic nature limits broader applicability and increases the risk of comorbidities. Immunotherapies, particularly immune checkpoint inhibitors and chimeric antigen receptor T-cell therapies, have transformed …


Efficacy And Safety Of Dapagliflozin In Patients Hospitalized With Covid-19 With And Without Type 2 Diabetes: A Prespecified Analysis Of The Dare-19 Randomized Trial, Mohammad Abdel Jawad, Ali Javaheri, Et Al. Jul 2025

Efficacy And Safety Of Dapagliflozin In Patients Hospitalized With Covid-19 With And Without Type 2 Diabetes: A Prespecified Analysis Of The Dare-19 Randomized Trial, Mohammad Abdel Jawad, Ali Javaheri, Et Al.

2020-Current year OA Pubs

BACKGROUND: Although several previous studies tested SGLT2 inhibitors in the setting of an acute, non-cardiovascular illness, detailed information on their efficacy and safety among participants with and without type 2 diabetes (T2D) from double-blind randomized trials is lacking. In this secondary prespecified analysis of the Dapagliflozin in Respiratory Failure in Patients with COVID-19 (DARE-19) trial, we sought to evaluate the safety and efficacy of initiating dapagliflozin during acute illness with COVID-19 in patients with and without T2D.

METHODS: The DARE-19 trial randomized 1250 patients hospitalized with COVID-19 and cardiometabolic risk factors to dapagliflozin or placebo. T2D was present in 636/1250 …


In Pursuit Of A Better Hospital Quality Metric For Medicare, Brad Wright Ph.D. Jul 2025

In Pursuit Of A Better Hospital Quality Metric For Medicare, Brad Wright Ph.D.

Faculty Publications

No abstract provided.


Long-Term Testosterone Pellet Insertion In Women With Low Libido Shows No Evidence Of Erythrocytosis And A Minimal Side Effect Profile, Amit Reddy, Bridget S Park, Jeffrey J Song, Gabrielle Lyon, Mohit Khera Jul 2025

Long-Term Testosterone Pellet Insertion In Women With Low Libido Shows No Evidence Of Erythrocytosis And A Minimal Side Effect Profile, Amit Reddy, Bridget S Park, Jeffrey J Song, Gabrielle Lyon, Mohit Khera

Faculty, Staff and Students Publications

Background: Testosterone therapy for low libido in women has become increasingly prevalent in recent years. While numerous testosterone formulations exist and have been studied in women, there has been little data assessing the safety and efficacy of subcutaneous testosterone pellet use in this population. The primary objective of this study is to understand the biochemical effects and side effect profile of female patients who underwent testosterone pellet insertion in a clinical practice.

Methods: A retrospective chart review of female patients who underwent testosterone pellet insertion from 2009 to 2022 was undertaken. Women taking 75 and 100 mg testosterone pellets were …


Unveiling Spatial Heterogeneity In Medulloblastoma: A Multi-Omics Analysis Of Cellular State And Geographical Organization, Jiao Zhang, Xuan Chen, Craig Daniels, Xiaochong Wu, Olivier Saulnier, Hiromichi Suzuki, Pasqualino De Antonellis, Alexandra Rasnitsyn, Winnie Ong, Evan Y Wang, Liam D Hendrikse, Yu Su, Yu Tian, Dongming Han, Ruohan Wang, Jialin Mo, Fei Liu, Kaiwen Deng, Dongyang Wang, Zhaoyang Feng, Yifei Jiang, Yanong Li, Yuting Ma, Zijia Liu, Meiyu Li, Peiyi Tian, Yanfeng Shi, Yong Jiang, Tao Yang, Shouwei Li, Jianfeng Liang, Jingchuan Wu, Ying Wang, Wanjing Zou, Yina Jiang, Lusheng Wang, Fang Chen, Xin Jin, Shuaicheng Li, Xiaoguang Qiu, Chunde Li, Ya Gao, Yujie Tang, Michael D Taylor, Tao Jiang Jul 2025

Unveiling Spatial Heterogeneity In Medulloblastoma: A Multi-Omics Analysis Of Cellular State And Geographical Organization, Jiao Zhang, Xuan Chen, Craig Daniels, Xiaochong Wu, Olivier Saulnier, Hiromichi Suzuki, Pasqualino De Antonellis, Alexandra Rasnitsyn, Winnie Ong, Evan Y Wang, Liam D Hendrikse, Yu Su, Yu Tian, Dongming Han, Ruohan Wang, Jialin Mo, Fei Liu, Kaiwen Deng, Dongyang Wang, Zhaoyang Feng, Yifei Jiang, Yanong Li, Yuting Ma, Zijia Liu, Meiyu Li, Peiyi Tian, Yanfeng Shi, Yong Jiang, Tao Yang, Shouwei Li, Jianfeng Liang, Jingchuan Wu, Ying Wang, Wanjing Zou, Yina Jiang, Lusheng Wang, Fang Chen, Xin Jin, Shuaicheng Li, Xiaoguang Qiu, Chunde Li, Ya Gao, Yujie Tang, Michael D Taylor, Tao Jiang

Faculty, Staff and Students Publications

Background: Despite numerous studies on medulloblastoma (MB) cell heterogeneity, the spatial characteristics of cellular states remain unclear.

Methods: We analyze single-nucleus and spatial transcriptomes and chromatin accessibility from human MB spanning four subgroups, to identify malignant cell populations and describe the spatial evolutionary trajectories. The spatial copy number variations (CNVs) patterns and niches were analyzed to investigate the cellular interactions.

Results: Three main malignant cell populations were identified, including progenitor-like, cycling, and differentiated populations. Gene signatures of cell populations strongly correlate to clinical outcomes. These tumor cell populations are geographically organized as stem-like and mature regions, highlighting their spatially heterogeneous …


Integrating Circulating Tumor Dna Into Clinical Management Of Colorectal Cancer: Practical Implications And Therapeutic Challenges, Sakshi Singal, Rishab Prabhu, Geetha Krishnamoorthy, Karen Riggins, Nagaishwarya Moka Jul 2025

Integrating Circulating Tumor Dna Into Clinical Management Of Colorectal Cancer: Practical Implications And Therapeutic Challenges, Sakshi Singal, Rishab Prabhu, Geetha Krishnamoorthy, Karen Riggins, Nagaishwarya Moka

Faculty, Staff and Students Publications

The American Cancer Society estimates that over 152,000 new cases of colorectal cancer (CRC) were diagnosed in 2024, with more than 105,000 cases affecting the colon and 46,000 involving the rectum. CRC remains the second leading cause of cancer-related deaths in the United States, with an estimated 53,010 deaths in 2024. In the era of precision medicine, which incorporates molecular and environmental information into clinical decision-making, identifying patients harboring a deficiency in Deoxyribonucleic acid (DNA) repair allowed for targeted immunotherapies and significantly reduced CRC-related mortality. A significant advancement in this domain is the application of liquid biopsy, which has emerged …


Systematic Review Of Parkinsonism In Cerebrotendinous Xanthomatosis Jul 2025

Systematic Review Of Parkinsonism In Cerebrotendinous Xanthomatosis

Faculty, Staff and Students Publications

Background: Cerebrotendinous Xanthomatosis (CTX) is a rare, inherited metabolic disease caused by pathogenic variants in CYP27A1. The clinical presentation of this progressive disease includes cognitive deficits, ataxia, peripheral neuropathy, and pyramidal signs, as well as bilateral cataracts and tendon xanthomas. In some cases, CTX also includes parkinsonism. The goals of this study are to develop a data source that provides improved characterization and awareness of parkinsonism in CTX.

Methods: We conducted a systematic review of the literature according to PRISMA guidelines to identify all published individuals diagnosed with CTX and parkinsonism. Clinical signs, imaging findings and treatment response to …


Central Lines And Peripherally Inserted Central Line Reeducation, Monica Lyn Gallik Jul 2025

Central Lines And Peripherally Inserted Central Line Reeducation, Monica Lyn Gallik

Walden Dissertations and Doctoral Studies

Objective: Will a central line and peripherally inserted central line reeducation program increase the nurses’ knowledge pertaining to dressing changes, cap changes, and chlorohexidine baths? Method: 26 nurses on an observation unit were sent a power point presentation. Of the 26 nurses that received the power point 18 nurses participated. The power point presentation had a pretest and posttest embedded into it. Both the pretest and posttest consist3ed of the same 10 questions. The average of the pretest and posttest were used to calculate the normalized learning gained. Results: The average pretest score was 60, the average posttest score was …


Extended-Release Buprenorphine With Bupivacaine Effectively Provides Postoperative Analgesia In A Mouse Laparotomy Model, Monika K. Huss, Amber Kerk, Renee Cotton, Helen Chum, Michael Hsieh, Katechan Jampachaisri, Patrick Sharp, Cholowat Pacharinsak Jul 2025

Extended-Release Buprenorphine With Bupivacaine Effectively Provides Postoperative Analgesia In A Mouse Laparotomy Model, Monika K. Huss, Amber Kerk, Renee Cotton, Helen Chum, Michael Hsieh, Katechan Jampachaisri, Patrick Sharp, Cholowat Pacharinsak

The Thai Journal of Veterinary Medicine

Multimodal analgesia is widely encouraged for major survival surgery. This facilitates lower doses of individual drugs, thereby reducing side effects. Extended-release analgesics offer sustained analgesia coverage, prevent drug dosing nadirs, and reduce stress. Studies evaluating multimodal and extended-release analgesia combinations for major survival surgery in mice are limited. We compared the analgesic effect of bupivacaine and extended-release buprenorphine (Bupi-ER) to bupivacaine and buprenorphine HCl (Bupi-HCl). We hypothesized that preoperative Bupi-ER would provide more effective analgesia than Bupi-HCl. Mice were randomly assigned to 1 of 2 treatment groups: bupivacaine (2 mg/kg, local infiltration, once) with either 1) extended-release buprenorphine (0.6 mg/kg, …


Coaching Bilingual Speech-Language Student Clinicians And Spanish-Speaking Caregivers To Use Culturally Adapted Ndbi Techniques For Autistic Preschoolers, Richelle R. Mcguire Jul 2025

Coaching Bilingual Speech-Language Student Clinicians And Spanish-Speaking Caregivers To Use Culturally Adapted Ndbi Techniques For Autistic Preschoolers, Richelle R. Mcguire

Speech and Hearing Sciences ETDs

This study used a cascading coaching model to train bilingual speech-language pathology graduate students and Spanish-speaking caregivers to implement naturalistic developmental behavioral intervention (NDBI) strategies with autistic preschoolers. Two triads, each including a student clinician, minimally vocal child with autism, and caregiver, participated. A monolingual instructor coached student clinicians in culturally adapted NDBI techniques, who then coached caregivers in Spanish. A mixed methods approach evaluated outcomes through single-case experimental design and qualitative interviews. All adult participants increased their use of targeted NDBI skills, with large to very large effect sizes. Qualitative findings suggested areas for improvement (e.g., need for more …


In Silico Prediction Of Cytotoxic T-Cell Epitopes From Helicobacter Pylori Virulence Factors Using An Immunoinformatics Approach, Demy Valerie Chacon, Kiana Alika Co, Daphne Noreen Enriquez, Aubrey Love Labarda, Reanne Eden Manongsong, Edward Kevin B. Bragais Jul 2025

In Silico Prediction Of Cytotoxic T-Cell Epitopes From Helicobacter Pylori Virulence Factors Using An Immunoinformatics Approach, Demy Valerie Chacon, Kiana Alika Co, Daphne Noreen Enriquez, Aubrey Love Labarda, Reanne Eden Manongsong, Edward Kevin B. Bragais

Biology Faculty Publications

Background: Helicobacter pylori infects approximately half of the global population, leading to gastric and duodenal ulcers. Despite the availability of antibiotics, challenges such as patient reluctance, high treatment costs, and antibiotic resistance limit their effectiveness, making vaccination a promising alternative. This study used immunoinformatics to identify candidate epitopes for a multiepitope vaccine construct against H. pylori.

Material and methods: The protein variability server was utilized for conservation analysis. The epitopes were screened for antigenicity, allergenicity, toxicity, cross-reactivity, and population coverage. Selected epitopes were docked with their corresponding human leukocyte antigen (HLA) alleles, and thermodynamic quantities were determined. Five virulence …


Hyperglycemia And Oral Health: A Review Of Dental Clinicians’ Perceptions And Practices Of Blood Glucose Monitoring In The Dental Office, Kathleen Wozniak Jul 2025

Hyperglycemia And Oral Health: A Review Of Dental Clinicians’ Perceptions And Practices Of Blood Glucose Monitoring In The Dental Office, Kathleen Wozniak

Dental Hygiene ETDs

This study aims to review the current practices and perceptions of dentists regarding the likelihood of dental professionals incorporating blood glucose monitoring into patient care protocol of patients with diabetes mellitus and prediabetes in dental offices. A survey link was shared by DentalOffices, a dental resource center. The survey included a series of questions which aimed to review dentists' current attitudes, practices, and considerations for implementation of in-office blood glucose testing as it relates to the treatment of patients with diabetes mellitus. Forty-seven dentists participated in the survey. This study determined blood glucose testing is not a common protocol or …


An Analysis Of Employment Patterns And Career Decisions Among Dental Hygienists: In A Transforming Healthcare Landscape, Shirley Calderon Jamarck Jul 2025

An Analysis Of Employment Patterns And Career Decisions Among Dental Hygienists: In A Transforming Healthcare Landscape, Shirley Calderon Jamarck

Dental Hygiene ETDs

The purpose of this study was to identify the factors contributing to dental hygienists’ consideration of changing careers, retiring early, or feeling burned out. A 26-question survey was emailed to members of the American Dental Hygienists’ Association, with 742 responses meeting inclusion criteria. Participants evaluated aspects of their careers, including job satisfaction, wages and benefits, personal growth, work-related stress, burnout, work-life balance, and retirement plans. Results revealed that one-third of respondents planned to leave the profession, citing burnout, physical strain, and limited career growth as reasons. High correlations were found between job satisfaction and feeling valued, professional accomplishment, and growth …


Scoping Review: Faktor – Faktor Yang Mempengaruhi Keputusan Lansia Memilih Senior Living, Nia Murniati, Badra Al Aufa, Mochamad Iqbal Nurmansyah Jul 2025

Scoping Review: Faktor – Faktor Yang Mempengaruhi Keputusan Lansia Memilih Senior Living, Nia Murniati, Badra Al Aufa, Mochamad Iqbal Nurmansyah

Jurnal Administrasi Bisnis Terapan

Abstract Senior living has emerged as an alternative solution to public health and social policy challenges amid the global acceleration of aging. Traditionally perceived as a last resort, life in senior living facilities is shaped by evolving dynamics in health, family, and society. This scoping review explores the key factors influencing older adults' decisions to reside in senior living communities during their later years. Utilizing Andersen’s Behavioral Model of Health Service Use as a theoretical framework, the review was conducted following PRISMA-ScR guidelines. Articles published between 2019 and 2024 were identified through searches in PubMed, Scopus, ProQuest, and Taylor & …