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Articles 23461 - 23490 of 325184
Full-Text Articles in Medicine and Health Sciences
Enhancing Patient Outcomes: The Sepsis Navigator Approach, Temeka L. Parker
Enhancing Patient Outcomes: The Sepsis Navigator Approach, Temeka L. Parker
Doctor of Nursing Practice Projects
Background: Sepsis is the leading cause of hospital mortality, accounting for over $20 billion dollars in total healthcare costs and more than 5 million deaths annually worldwide. The increased burden of sepsis led the Centers for Medicare and Medicaid (CMS) to institute a quality core measure known as the Severe Sepsis and Septic Shock Management Bundle (SEP-1) as a protocol for sepsis treatment. CMS reports national SEP-1 compliance at 62% and 61% for Alabama. The undisclosed project site reports a much lower SEP-1 compliance average of 49% over six months. Compliance with the SEP-1 bundle improves overall patient outcomes and …
Commit To Sit: Does Purposefully Sitting With Adult Medical-Surgical Patients At A Rural Hospital Impact Patient Satisfaction?, Jolie A. Puckett
Commit To Sit: Does Purposefully Sitting With Adult Medical-Surgical Patients At A Rural Hospital Impact Patient Satisfaction?, Jolie A. Puckett
Doctor of Nursing Practice Projects
Background: Patient satisfaction surveys encourage patients to provide feedback about their experiences with healthcare organizations, and the surveys also play a critical role in identifying gaps in care that may contribute to patient harm. Effective communication between nurses and patients is crucial for delivering high-quality healthcare; therefore, initiatives to enhance this communication should be explored and implemented.
Purpose: This quality improvement project aimed to evaluate whether sitting with patients improved patient satisfaction scores for a medical-surgical unit within a Northwest Georgia inpatient facility.
Project Design: A pre- and post-design method was utilized to compare patient satisfaction scores before and after …
Utilizing Text Messaging To Increase Annual Mammogram Screening Compliance, Lacey B. Santa Cruz
Utilizing Text Messaging To Increase Annual Mammogram Screening Compliance, Lacey B. Santa Cruz
Doctor of Nursing Practice Projects
Background: Routine mammography can lessen breast cancer deaths, but many patients do not follow the current screening guidelines. Limited access to mammography and insufficient awareness lead to missed screening appointments.
Purpose: The purpose of this Doctor of Nursing Practice (DNP) project was to improve annual mammogram adherence among women aged 40-74 by implementing an electronic medical record (EMR)-based text reminder system.
Project Design: Secondary patient data was collected from a privately owned, rural family practice clinic. Using the Mobilize-Assess-Plan-Implement-Track (MAP-IT) quality improvement framework, the project implemented a text message reminder intervention through the EMR. Eligible patients received a text reminder …
Persistent Imbalance: Women’S Representation In North American Pediatric Cardiology Leadership Roles.Persistent Imbalance: Women’S Representation In North American Pediatric Cardiology Leadership Roles, Alaina K. Kipps, Audrey C. Marshall, Neha Bansal, Holly Bauser-Heaton, Nadine Choueiter, Devyani Chowdhury, Aarti Dalal, Molly Ehrlich, Lindsay R. Freud, Supriya S. Jain, Pei-Ni Jone, Kristin Laraja, Dalia Lopez-Colon, Sonal T. Owens, Christina Ronai, Ritu Sachdeva, Corey Stiver, Nicole Sutton, Terrie Vasilopoulos, Jennifer Co-Vu
Persistent Imbalance: Women’S Representation In North American Pediatric Cardiology Leadership Roles.Persistent Imbalance: Women’S Representation In North American Pediatric Cardiology Leadership Roles, Alaina K. Kipps, Audrey C. Marshall, Neha Bansal, Holly Bauser-Heaton, Nadine Choueiter, Devyani Chowdhury, Aarti Dalal, Molly Ehrlich, Lindsay R. Freud, Supriya S. Jain, Pei-Ni Jone, Kristin Laraja, Dalia Lopez-Colon, Sonal T. Owens, Christina Ronai, Ritu Sachdeva, Corey Stiver, Nicole Sutton, Terrie Vasilopoulos, Jennifer Co-Vu
Department of Pediatrics Faculty Papers
BACKGROUND: Despite recent gender parity of physicians entering pediatric cardiology, representation of women leaders lags their male colleagues.
OBJECTIVES: We sought to better understand the variation in women in leadership roles in pediatric cardiology.
METHODS: The gender of physicians in 16 prespecified leadership positions was collected by survey between July 2022 and January 2023 from pediatric cardiology programs with >5 cardiologists in North America. We analyzed the association of women leaders with center size (based on surgical volume), geographic region, presence of categorical fellowship program, and gender of division chief and department chair.
RESULTS: Across 99 centers, a median of …
Using The Observational Medical Outcomes Partnership Common Data Model For A Multi-Registry Intensive Care Unit Benchmarking Federated Analysis: Lessons Learned, Aasiyah Rashan, Daniel P Püttmann, Nicolette F De Keizer, Dave A Dongelmans, Ronald Cornet, Otavio Ranzani, Wangari Siika, Matthew Smith, Steve Harris, Abi Beane
Using The Observational Medical Outcomes Partnership Common Data Model For A Multi-Registry Intensive Care Unit Benchmarking Federated Analysis: Lessons Learned, Aasiyah Rashan, Daniel P Püttmann, Nicolette F De Keizer, Dave A Dongelmans, Ronald Cornet, Otavio Ranzani, Wangari Siika, Matthew Smith, Steve Harris, Abi Beane
Anaesthesiology, East Africa
Objective: Federated analysis is a method that allows data analysis to be performed on similar datasets without exchanging any data, thus facilitating international research collaboration while adhering to strict privacy laws. This study aimed to evaluate the feasibility of using federated analysis to benchmark mortality in 2 critical care quality registry databases converted to the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM), describing challenges to and recommendations for performing federated analysis on data transformed to OMOP CDM.
Materials and Methods: To identify as many challenges as possible and to be able to complete the benchmarking phase, …
Biocomputing Approach To Modeling And Modulating Calcium Signaling, Sehee Sun
Biocomputing Approach To Modeling And Modulating Calcium Signaling, Sehee Sun
School of Computing: Dissertations, Theses, and Student Research
Biocomputing is an emerging field that seeks to perform computational tasks using biological substrates and processes. Unlike conventional computing systems based on silicon hardware, biocomputing leverages the parallelism, energy efficiency, and complex dynamics of living systems. Among various cellular mechanisms, calcium (Ca2+) signaling stands out as a central regulator of diverse biological functions, offering a promising basis for programmable logic and control in living cells.
This thesis introduces a novel framework for modeling and modulating Ca2+ dynamics using biologically inspired Boolean logic circuits. Specifically, we propose the Ca2+ Boolean Logic (CaBL) model, in which Ca2+ fluxes and interactions are abstracted …
Translating The Hba1c Lab Test Name And Results From English To Arabic For Enhanced Patient Access And Workflow Efficiency, Aiman M. Alrawabdeh
Translating The Hba1c Lab Test Name And Results From English To Arabic For Enhanced Patient Access And Workflow Efficiency, Aiman M. Alrawabdeh
Translational Projects (Open Access)
In Jordan, where the healthcare system primarily operates in English, Arabic-speaking patients encounter significant challenges in understanding laboratory test names and results, including Hemoglobin A1c (HbA1c), an essential diagnostic indicator for diabetes management. The lack of multilingual access to medical information limits health literacy and patient autonomy, increasing dependence on healthcare staff for translation assistance. This translational informatics project addressed these challenges by developing and implementing an Arabic translation process for the HbA1c lab test name and results. HbA1c was selected as it is a standard lab test among patients with diabetes in Jordan; nearly 30% of Jordanians had type …
Artificial Intelligence In Healthcare And Science, Sally Brown, Catherine Gouge, Anurag Srivastava
Artificial Intelligence In Healthcare And Science, Sally Brown, Catherine Gouge, Anurag Srivastava
Artificial Intelligence Exhibit
This section explores AI's impact on science and healthcare, including medical diagnostics and treatments, and scientific research.
The Impact Of Respiratory Muscle Training On Respiratory Function In Patients With Neuromuscular Disease: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Nancy Y. Ortiz-Garcia, Diego Eduardo Rueda-Capristran, Ajay Kumar, Domenica Alejandra Herrera, Angie Carolina Alonso-Ramírez, Diana Othón-Martínez, Jonathan Reyes-Rivera, Frances Marie Mejia, Jonathan David Martinez-Illan, Carla Isabella Miret Durazo
The Impact Of Respiratory Muscle Training On Respiratory Function In Patients With Neuromuscular Disease: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Nancy Y. Ortiz-Garcia, Diego Eduardo Rueda-Capristran, Ajay Kumar, Domenica Alejandra Herrera, Angie Carolina Alonso-Ramírez, Diana Othón-Martínez, Jonathan Reyes-Rivera, Frances Marie Mejia, Jonathan David Martinez-Illan, Carla Isabella Miret Durazo
School of Medicine Publications
Background: Neuromuscular diseases (NMDs) can impair respiratory muscle function, leading to increased morbidity and mortality. Respiratory muscle training (RMT) is widely used to manage these respiratory complications, but its efficacy across different NMDs remains unclear. This systematic review and meta-analysis evaluated the impact of physiotherapy interventions, specifically RMT, on respiratory muscle function in NMD patients.
Methods: A systematic search of multiple databases, including MEDLINE, EMBASE, Web of Science, Cochrane, CRS-Web, PEDro, LILACS, ICTPR, the China National Knowledge Infrastructure database, and ClinicalTrials.gov, was conducted up to February 2025. Randomized controlled trials (RCTs) and cohort studies evaluating RMT's effect on lung volumes …
Pharmacological Profiling Of Major Depressive Disorder-Related Multimorbidity Clusters, Tamas Nagy, Xenia Gonda, Andras Gezsi, Nora Eszlari, Gabor Hullam, Rubèn González-Colom, Hannu Mäkinen, Hannu Mäkinen, Mikko Kuokkanen
Pharmacological Profiling Of Major Depressive Disorder-Related Multimorbidity Clusters, Tamas Nagy, Xenia Gonda, Andras Gezsi, Nora Eszlari, Gabor Hullam, Rubèn González-Colom, Hannu Mäkinen, Hannu Mäkinen, Mikko Kuokkanen
School of Medicine Publications
We previously identified seven distinct multimorbidity clusters associated with major depressive disorder through a comprehensive analysis of 1.2 million individuals of multiple cohorts. These clusters, characterized by unique clinical, genetic, and psychiatric and somatic illness risk profiles, implicate divergent treatment pathways and disease management strategies. This study aims to deepen the understanding of these clusters by analyzing drug prescriptions, evaluating the effectiveness of antidepressant treatment strategies, and identifying potential markers for personalized medicine. Utilizing drug prescription data in the format of ATC codes, we performed epidemiological assessments, including multimorbidity (number of diseases), polypharmacy (number of chemical substances), and …
Investigating Environmental And Socioeconomic Contributors To Adult Obesity In The Rio Grande Valley, John Nicholas Cauba, Jihoo Woo, Russel Wiggins, Shizue Mito
Investigating Environmental And Socioeconomic Contributors To Adult Obesity In The Rio Grande Valley, John Nicholas Cauba, Jihoo Woo, Russel Wiggins, Shizue Mito
School of Medicine Publications
Obesity in the Rio Grande Valley (RGV) of Texas remains a critical public health concern, with rates (46.9%) significantly exceeding those of Texas (36%) and the U.S. (34%) (p < 0.001). This study used 2024 County Health Rankings data to analyze environmental and socioeconomic contributors to obesity across 240 Texas counties, with a population-weighted focus on Hidalgo, Cameron, Starr, and Willacy counties. The RGV exhibited markedly poorer access to exercise, higher rates of physical inactivity, lower Food Environment Index scores (FEI = 4.3 vs. 5.7 in Texas), higher rates of uninsurance, worse patient-to–primary care physician (PCP) ratios (2152:1 vs. Texas 1660:1), and increased preventable hospitalizations. Multiple linear regression identified physical inactivity (β = 0.6, p = 0.01) and access to exercise (β = −0.02, p = 0.02) as significant predictors of obesity. Notably, higher uninsured rates were associated with lower reported obesity, likely due to underdiagnosis in the absence of routine care. These findings emphasize the need for targeted interventions addressing food access, environmental and recreational infrastructure, along with healthcare infrastructure in the RGV, where socioeconomic disadvantage and structural barriers magnify the impact of national obesity trends on the regional level.
Exploring The Efficacy Of Various Minimally Invasive Surgery (Mis) Techniques In Spinal Fusion For Degenerative Spondylolisthesis: A Systematic Review, Yolanda V. Gutierrez, Blake Martin, Joshua Nwose, Alyssa A. Sepulveda, Ronald Shaju, Aamir Ahmad, Robert H. Ablove
Exploring The Efficacy Of Various Minimally Invasive Surgery (Mis) Techniques In Spinal Fusion For Degenerative Spondylolisthesis: A Systematic Review, Yolanda V. Gutierrez, Blake Martin, Joshua Nwose, Alyssa A. Sepulveda, Ronald Shaju, Aamir Ahmad, Robert H. Ablove
School of Medicine Publications
Degenerative spondylolisthesis is a common etiology of low back pain characterized by the anterior displacement of one vertebral body relative to the one below it. A key contributing factor is intervertebral disc degeneration, which compromises spinal stability. In patients with a lack of neurological issues, conservative treatment is recommended. If conservative treatment is ineffective, surgery is deemed the next step, involving decompression and fusion of the vertebrae. Over the past several decades, minimally invasive surgical (MIS) techniques have been developed and refined. This systematic review aims to compare different types of MIS techniques for the treatment of degenerative spondylolisthesis to …
Amyloid Accumulation, Brain Atrophy, And Cognitive Decline In Emergent Alzheimer's Disease, Ying Xia, Pierrick Bourgeat, Vincent Doré, Jurgen Fripp, Yen Ying Lim, Simon M. Laws, Christopher Fowler, Christopher C. Rowe, Colin L. Masters, Elizabeth J. Coulson, Paul Maruff
Amyloid Accumulation, Brain Atrophy, And Cognitive Decline In Emergent Alzheimer's Disease, Ying Xia, Pierrick Bourgeat, Vincent Doré, Jurgen Fripp, Yen Ying Lim, Simon M. Laws, Christopher Fowler, Christopher C. Rowe, Colin L. Masters, Elizabeth J. Coulson, Paul Maruff
Research outputs 2022 to 2026
Introduction : Emergent Alzheimer's disease (AD) represents a transitional stage where cognitively unimpaired (CU) individuals exhibit subthreshold but increasing amyloid-β (Aβ) levels. The impact of Aβ accumulation on brain volume loss and cognition during this early stage remains unclear. Methods: This retrospective cohort study analyzed data from 408 CU participants who were initially Aβ− (< 15 Centiloids) and followed for up to 15 years. Changes in basal forebrain and hippocampal volume, along with domain-specific cognitive performance, were compared between those who progressed to Aβ+ (≥20 Centiloids) and those who remained Aβ−. Results: Sixty-five CU participants progressed to Aβ+, indicating emergent AD, and showed faster Aβ accumulation and subtle memory decline. However, no significant differences in rate of BF and hippocampal atrophy were observed between groups. Discussion: The results suggest that during this emergent phase of AD, Aβ accumulation is associated with episodic memory loss, in the absence of detectable accelerated brain atrophy. Highlights: Identified cognitively unimpaired individuals in the emergent stage of Alzheimer's disease (AD). Emergent AD exhibits a greater rate of amyloid-β (Aβ) accumulation. No accelerated volume loss detected in the basal forebrain or hippocampus. Emergent AD is also associated with a subtle decline in memory. Early Aβ accumulation may impair cognitive function before structural atrophy.
Perioperative Business Services, Laila Perez, Jacquelyn Mancini Mba
Perioperative Business Services, Laila Perez, Jacquelyn Mancini Mba
Research Scholars
No abstract provided.
Investigating The Neural Mechanisms Underlying Values-Based Leadership Behavior, Brooke Johnson, Gerald Mcglinn M.A., Acc
Investigating The Neural Mechanisms Underlying Values-Based Leadership Behavior, Brooke Johnson, Gerald Mcglinn M.A., Acc
Research Scholars
No abstract provided.
Inflammatory Bowel Disease: Patient Journey And Cancer Pathology, Katie Contino, Ms
Inflammatory Bowel Disease: Patient Journey And Cancer Pathology, Katie Contino, Ms
Student Papers, Posters & Projects
Inflammatory Bowel Disease is a relapsing-remitting autoimmune disease that affects the gastrointestinal tract. It consists of Crohn’s disease, which can affect the entire gastrointestinal system, and ulcerative colitis, which is limited to the colon. Inflammatory Bowel Disease has various different levels of severity that have different treatment and medication options once the diagnosis is confirmed with an endoscopic procedure. The treatment options range from daily medication to invasive surgical procedures. Specific diets are also used as a preventative measure to remain in remission. The intestinal damage inflicted to the epithelium increases the risk of developing colon cancer, specifically those with …
Systemic Exogenous Progestins With Or Without Estrogens Are Associated With Decreased Rates Of Venous Procedures For Varicose Veins, Paarth Jain, Adam M. Ostrovsky, Paul J Dimuzio, Luis H. Eraso, Michael Nooromid, Dawn Salvatore, Babak Abai
Systemic Exogenous Progestins With Or Without Estrogens Are Associated With Decreased Rates Of Venous Procedures For Varicose Veins, Paarth Jain, Adam M. Ostrovsky, Paul J Dimuzio, Luis H. Eraso, Michael Nooromid, Dawn Salvatore, Babak Abai
Department of Surgery Faculty Papers
OBJECTIVES: Risk factors for varicose veins (VVs) such as female sex, pregnancy, and obesity are high estrogen states, yet the role of systemic progestins with or without estrogens (SPEs) in VV management is not well characterized. This study investigates how SPE use affects rates of venous procedures for patients with VV.
METHODS: The TriNetX database was queried for subjects with International Classification of Diseases, 10th edition, diagnoses of asymptomatic VV, chronic venous insufficiency, and complicated VV (inflammation or ulceration). Patients were divided into a control cohort with no subsequent SPE use, a progestin-only cohort, and a combined estrogen-progestin (CEP) cohort. …
Exploring Covid-19 Vaccination Behavior: A Cross-Country Study Among Pregnant And Postpartum Women In Brazil, Ghana, Kenya, And Pakistan, Rupali Limaye, Berrhaun Fesshaye, Emily Miller, Prachi Singh, Saleem Jessani, Muhammad Asim, Ferdinand Okwaro, Sarah Saleem, Marleen Temmerman, Muhammad Asim
Exploring Covid-19 Vaccination Behavior: A Cross-Country Study Among Pregnant And Postpartum Women In Brazil, Ghana, Kenya, And Pakistan, Rupali Limaye, Berrhaun Fesshaye, Emily Miller, Prachi Singh, Saleem Jessani, Muhammad Asim, Ferdinand Okwaro, Sarah Saleem, Marleen Temmerman, Muhammad Asim
Centre of Excellence in Women and Child Health
Pregnant women infected with SARS-CoV2 are more likely to be hospitalized and require ventilation, compared to non-pregnant women. Although the development of the COVID-19 vaccine was regarded as a scientific breakthrough among many, the pace of development in combination with delayed and unclear recommendations for maternal vaccination led to slower vaccine uptake among this population. We explored the decision-making process for COVID-19 vaccination among pregnant and postpartum women in four countries: Brazil, Ghana, Kenya, and Pakistan through 201 in-depth interviews. A grounded theory approach was used for analysis, and a socio-ecological framework was used to synthesize emerging themes. Four levels …
Beyond The Bone: A Misdiagnosis Of Paget’S Disease Reveals Polyostotic Mazabraud Syndrome, Michael Higham, Stephanie Campbell, Amanda Killeen
Beyond The Bone: A Misdiagnosis Of Paget’S Disease Reveals Polyostotic Mazabraud Syndrome, Michael Higham, Stephanie Campbell, Amanda Killeen
School of Podiatric Medicine Publications
Introduction: Mazabraud Syndrome is a rare benign condition characterized by polyostotic fibrous dysplasia and intramuscular myxomas. Due to its overlapping radiographic features, it is frequently misdiagnosed. We present a case where Mazabraud Syndrome was misdiagnosed as Paget’s disease for nearly 6 decades.
Case Presentation: A 59-year-old woman presented to the podiatry clinic with complaints of numbness and sharp pain of the left foot while in stance. Her surgical history is positive for numerous lower extremity myxomas excised over her lifetime, beginning in adolescence, and now with non-mobile soft tissue mass at the porta pedis of the left foot for 1 …
Issues That Ministers Identify As Factors Contributing To Anxiety And Depression, Heather Sawtelle
Issues That Ministers Identify As Factors Contributing To Anxiety And Depression, Heather Sawtelle
Doctor of Ministry (DMin)
Although mental health is an emerging topic within the church community, the stigmatization of mental illness within ministers’ lives can create a myriad of personal beliefs that can lead to shame and discontent in ministers’ lives. Many ministers have daily stressors that compromise their mental health, and these stressors can contribute to depression or anxiety. This study defined mental health issues and described mental illness’ influence on ministers’ lives and the factors that contribute to mental health issues. This health condition, described as mental illness, involves significant changes in thinking, emotion, behavior, distress, and problems functioning in social, work, or …
Dean's Report- Summer-Fall 2025, Marina K. Holz
Dean's Report- Summer-Fall 2025, Marina K. Holz
GSBMS Dean’s Report
No abstract provided.
Cazyme Gene Cluster Diversity In Human Gut Microbiome, Yi Xing
Cazyme Gene Cluster Diversity In Human Gut Microbiome, Yi Xing
Department of Food Science and Technology: Dissertations, Theses, and Student Research
In gut microbiome research, carbohydrate-active enzyme gene clusters (CGCs) have emerged as key functional units for understanding microbial glycan degradation. Unlike taxonomic or broad pathway annotations, CGCs offer gene-cluster-level resolution and capture substrate-specific microbial functions. However, their diversity and distribution in relation to host metabolic phenotypes, such as obesity, remain poorly characterized. This study tests the hypothesis that the composition and abundance of fiber-targeting CGCs vary between obese and healthy human gut microbiomes, reflecting distinct microbial carbohydrate utilization strategies. To examine this, we constructed a high-quality reference CGC dataset comprising 94,019 clusters from the Unified Human Gastrointestinal Genome and profiled …
Overcoming Maternal Antibody Interference In Swine Influenza: Advancing Dna Vaccine Strateies For Enhanced Immune Protection In Piglets, Danh Cong Lai
Overcoming Maternal Antibody Interference In Swine Influenza: Advancing Dna Vaccine Strateies For Enhanced Immune Protection In Piglets, Danh Cong Lai
School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research
Maternally derived antibodies (MDAs) play a vital role in protecting neonates from infectious diseases, but their presence at the time of vaccination can interfere with vaccine-induced immune responses, thereby reducing vaccine effectiveness. MDA interference has been documented in pigs vaccinated with whole inactivated virus (WIV) vaccines against swine influenza A virus (IAV). In this thesis, we evaluated the efficacy of a lipid nanoparticle encapsulated DNA (LNP-DNA) vaccine against swine IAV in the presence and absence of MDAs, comparing it to a WIV vaccine. In MDA-negative piglets, both the LNP-DNA and WIV vaccines induced strong immune responses and effectively prevented the …
Evaluation Of Snap-Ed New Mexico’S Pilot “I Choose H2o” Campaign To Increase Water Consumption, Theresa H. Cruz, Mahtab Soleimani, Camille R. Velarde, Belinda E. Vicuna
Evaluation Of Snap-Ed New Mexico’S Pilot “I Choose H2o” Campaign To Increase Water Consumption, Theresa H. Cruz, Mahtab Soleimani, Camille R. Velarde, Belinda E. Vicuna
Reports & Documents
The “I Choose H2O” campaign is a school-based pilot initiative developed by the University of New Mexico Prevention Research Center with SNAP-Ed NM funding from the USDA. Designed as a three-week social marketing effort, the campaign aimed to increase daily water consumption and reduce intake of sugar-sweetened beverages (SSBs) among middle school students. The campaign engaged students and staff through activities such as water challenges, events, tastings, and prize incentives, while also encouraging broader school-level policy, systems, and environmental (PSE) changes.
This evaluation used direct observation before and after implementation to assess changes in water fountain usage and lunchtime beverage …
Who Reconstitutes The Chemotherapy? The Educational And Practice Needs Of Oncology Pharmacists In West Africa: A Call For Multidisciplinary Team Approach In Oncology Care., Runcie C.W. Chidebe, Ramatu M. Alabelewe, Krishna Prasad Sapkota, Darlingtina K. Esiaka, Candidus C. Nwakasi, Gloria C. Okwu, Jacinta Emejulu, Adamu A. Umar, Ndifreke Okwuegbunam, Funsho David, Toyosi Adepoju, Agha A. Agha, Ejike S. Ugwu, Simeon C. Aruah, Richard Mshelia, Rob Duncombe, Noel N. Wannang, Peace C. Babalola, R. Donald Harvey, Cindy O'Bryant, Folakemi T. Odedina
Who Reconstitutes The Chemotherapy? The Educational And Practice Needs Of Oncology Pharmacists In West Africa: A Call For Multidisciplinary Team Approach In Oncology Care., Runcie C.W. Chidebe, Ramatu M. Alabelewe, Krishna Prasad Sapkota, Darlingtina K. Esiaka, Candidus C. Nwakasi, Gloria C. Okwu, Jacinta Emejulu, Adamu A. Umar, Ndifreke Okwuegbunam, Funsho David, Toyosi Adepoju, Agha A. Agha, Ejike S. Ugwu, Simeon C. Aruah, Richard Mshelia, Rob Duncombe, Noel N. Wannang, Peace C. Babalola, R. Donald Harvey, Cindy O'Bryant, Folakemi T. Odedina
Behavioral Science Faculty Publications
PURPOSE: Oncology pharmacists (OPs) play a crucial role in cancer care, treatment, survivorship, and multidisciplinary teams (MDTs). OPs have specialized training in designing, administering, monitoring, and modifying oncology chemotherapy; managing adverse events; and evaluating clinical trials and investigational drugs. Yet, the state of OP has remained largely unknown in the clinical oncology workforce of the West African region. Therefore, this study aimed to understand who reconstitutes chemotherapy and to explain the OP educational and practice needs, challenges, and solutions in Nigeria.
MATERIALS AND METHODS: Using a concurrent embedded mixed method design, 35 OPs completed a questionnaire, and 12 others responded …
Impact Of The Adjunctive Use Of Omega-3 In Periodontitispatients With Diabetes On Local And Systemic Chemerin Levels:A Randomized Clinical Trial, Dalia Ghalwash, Ahmed M. Ammar, Ayman El-Gawish, Ahmed Hamdy
Impact Of The Adjunctive Use Of Omega-3 In Periodontitispatients With Diabetes On Local And Systemic Chemerin Levels:A Randomized Clinical Trial, Dalia Ghalwash, Ahmed M. Ammar, Ayman El-Gawish, Ahmed Hamdy
Dentistry
Aims: The present study aspired to evaluate the impact of the adjunctive use of omega-3 with nonsurgical periodontal therapy onclinical parameters as well as local and systemic chemerin levels as a marker of cardiovascular disease risk in periodontitis patientswith diabetes.Methods: This randomized clinical trial was performed on thirty periodontitis patients with type II diabetes divided into two equalgroups, both treated by nonsurgical periodontal treatment with the adjunctive use of daily 1000 mg Omega-3FAs in group I onlyfor 6 months. Patients were reexamined after 2 weeks (baseline), 3, and 6 months for recording the clinical parameters as follows:plaque index (PI), gingival …
Evaluating Large Language Model Performance To Support The Diagnosis And Management Of Patients With Primary Immune Disorders, Nicholas L Rider, Yingya Li, Aaron T Chin, Daniel V Digiacomo, Cullen Dutmer, Jocelyn R Farmer, Kirk Roberts, Guergana Savova, Mei-Sing Ong
Evaluating Large Language Model Performance To Support The Diagnosis And Management Of Patients With Primary Immune Disorders, Nicholas L Rider, Yingya Li, Aaron T Chin, Daniel V Digiacomo, Cullen Dutmer, Jocelyn R Farmer, Kirk Roberts, Guergana Savova, Mei-Sing Ong
Faculty, Staff and Student Publications
Background: Generative artificial intelligence (GAI) is transforming health care in a variety of ways; however, the present utility of GAI for supporting clinicians who treat rare disease such as primary immune disorders (PIs) is not well studied. We evaluated the ability of 6 state-of-the-art large language models (LLMs) for providing clinical guidance about PIs.
Objective: To quantitatively and qualitatively measure the utility of current, open-source LLMs for diagnosing and providing helpful clinical decision support about PIs.
Methods: Five expert clinical immunologists each provided 5 real-world, anonymized PI case vignettes via multi-turn prompting to 6 LLMs (OpenAI GPT-4o, Llama-3.1-8B-Instruct, Llama-3.1-70B-Instruct, Mistral-7B-Instruct-v0.3, …
The Landscape Of Malignant Transition: Unraveling Cancer Cell-Of-Origin And Heterogeneous Tissue Microenvironment, Ruihan Luo, Jiajia Liu, Tiangang Wang, Weiling Zhao, Yanfei Wang, Jianguo Wen, Hongyu Wang, Shanli Ding, Xiaobo Zhou
The Landscape Of Malignant Transition: Unraveling Cancer Cell-Of-Origin And Heterogeneous Tissue Microenvironment, Ruihan Luo, Jiajia Liu, Tiangang Wang, Weiling Zhao, Yanfei Wang, Jianguo Wen, Hongyu Wang, Shanli Ding, Xiaobo Zhou
Faculty, Staff and Student Publications
Understanding disease progression and sophisticated tumor ecosystems is imperative for investigating tumorigenesis mechanisms and developing novel prevention strategies. Here, we dissected heterogeneous microenvironments during malignant transitions by leveraging data from 1396 samples spanning 13 major tissues. Within transitional stem-like subpopulations highly enriched in precancers and cancers, we identified 30 recurring cellular states strongly linked to malignancy, including hypoxia and epithelial senescence, revealing a high degree of plasticity in epithelial stem cells. By characterizing dynamics in stem-cell crosstalk with the microenvironment along the pseudotime axis, we found differential roles of ANXA1 at different stages of tumor development. In precancerous stages, reduced …
The Effect Of Individual Variation On Epidemiological Dynamics: From Super-Spreaders To Landscapes Of Risk, Alexis Shannon Beagle
The Effect Of Individual Variation On Epidemiological Dynamics: From Super-Spreaders To Landscapes Of Risk, Alexis Shannon Beagle
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Individuals that make up a population always display some level of variation between members. At the smallest scale, individuals always maintain genetic variation, but variation continues to arise at other scales of biological organization from physiological or immunological variation within individuals to variation in behavior between individuals that can be both genetically and environmentally mediated. The role of individual variation is particularly important in the context of infectious diseases because there is strong evidence that infections are highly heterogenous, indicating that patterns of individual variation drive a significant portion of the epidemiological patterns we observe. Individual variation leads to heterogeneity …
Use Of High-Throughput Phenomics With And Without Fungicide As A Wheat Breeding Tool, Gerardo Ivan Rivera Collazo
Use Of High-Throughput Phenomics With And Without Fungicide As A Wheat Breeding Tool, Gerardo Ivan Rivera Collazo
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Wheat (Triticum aestivum) is an important food staple for many countries around the world and current consumption and production data demonstrate a production deficit. Breeders are challenged to help close this gap in production by selecting better cultivars with improved yields. Several methods aim to accelerate the breeding process to reduce the time required for releasing an elite variety. One of the main breeding bottlenecks is the lack of fast and reliable phenotypic data acquisition that could dissect physiological and morphological plant data. High-throughput remote sensing could have the potential to reduce this bottleneck by streamlining data acquisition, …