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Articles 20731 - 20760 of 324909
Full-Text Articles in Medicine and Health Sciences
Hurricane Katrina Archive: Faculty Publications Bibliography 2020-2025, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse
Hurricane Katrina Archive: Faculty Publications Bibliography 2020-2025, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse
LSUHSC Hurricane Katrina Archive: Bibliographies
This bibliography includes 10 articles about Hurricane Katrina written by authors affiliated with LSU Health – New Orleans between January 2020 and August 2025.
Hurricane Katrina Archive: E-Books And E-Journals A To Z Bibliography 2020-2025, Lsu Health Sciences Center - New Orleans Libraries, Elizabeth H. Holt
Hurricane Katrina Archive: E-Books And E-Journals A To Z Bibliography 2020-2025, Lsu Health Sciences Center - New Orleans Libraries, Elizabeth H. Holt
LSUHSC Hurricane Katrina Archive: Bibliographies
This bibliography includes 43 electronic books and edited collections created on the topic of Hurricane Katrina by authors and others affiliated with LSU Health Sciences Center - New Orleans between September 2005 and August 2025.
Staff Education To Reduce Alarm Fatigue And Enhance Patient Safety Through Nurse Education On Telemetry Optimization, Casey Alan Metcalf
Staff Education To Reduce Alarm Fatigue And Enhance Patient Safety Through Nurse Education On Telemetry Optimization, Casey Alan Metcalf
Walden Dissertations and Doctoral Studies
Summary This project was an evidence-based staff education initiative to reduce alarm fatigue and enhance patient safety through telemetry optimization in an acute care setting. The core issue involved the overuse of continuous cardiac monitoring, which contributed to nonactionable alarms, alarm fatigue, workflow inefficiencies, delayed throughput, and increased costs. The project was a structured intervention delivered to 171 telemetry nurses across three inpatient units. Pretests and posttests measured changes in knowledge, intent, and practice. Results showed a 22.9% increase in knowledge, a 92% agreement regarding intention to follow discontinuation protocols, and a 10% overall reduction in practice of telemetry use …
Need A Buddy? A Mentorship Program For New Graduate Nurses, Makenzie Smith, Clarissa Leal, Danae Jones, Tram Anh Tran, Serenity Helaire
Need A Buddy? A Mentorship Program For New Graduate Nurses, Makenzie Smith, Clarissa Leal, Danae Jones, Tram Anh Tran, Serenity Helaire
2024
No abstract provided.
Hurricane Katrina Archive: Libraries Catalog Bibliography, Lsu Health Sciences Center - New Orleans Libraries, Elizabeth H. Holt
Hurricane Katrina Archive: Libraries Catalog Bibliography, Lsu Health Sciences Center - New Orleans Libraries, Elizabeth H. Holt
LSUHSC Hurricane Katrina Archive: Bibliographies
This bibliography includes 15 books, videos, and edited collections created on the topic of Hurricane Katrina by authors and others affiliated with LSU Health Sciences Center - New Orleans between September 2005 and August 2025.
Understanding User Needs In Health Crisis Risk Monitoring Information System Development: A Lesson From Tasikmalaya District, Indonesia, Arief Tarmansyah Iman, Hari Kusnanto, Ariani Arista Putri Pertiwi
Understanding User Needs In Health Crisis Risk Monitoring Information System Development: A Lesson From Tasikmalaya District, Indonesia, Arief Tarmansyah Iman, Hari Kusnanto, Ariani Arista Putri Pertiwi
Kesmas
A health crisis risk monitoring information system needs to be developed, especially during the pre-disaster phase; therefore, understanding the needs of prospective users is crucial. This study aimed to investigate the needs of potential users regarding the development of this system. This study employed a qualitative, exploratory approach to gather user needs from stakeholders through interviews (n = 7) and one focus group discussion (n = 12). The data were audio-recorded, transcribed verbatim, and then thematically analyzed using qualitative content analysis. The need for information was related to disaster preparedness and its preferred format. The system should be targeted, multiplatform, …
Staged Reconstruction And Salvage Of A Small Finger With A Corticocancellous Distal Radius Autograft: A Case Report, Emmanuel Franco, Zayd Ayas, Frank Gerold
Staged Reconstruction And Salvage Of A Small Finger With A Corticocancellous Distal Radius Autograft: A Case Report, Emmanuel Franco, Zayd Ayas, Frank Gerold
School of Medicine Publications
Finger reconstruction in the aftermath of severe trauma poses significant challenges in restorative surgery, particularly when addressing extensive soft tissue damage, comminuted fractures, and simultaneous neurovascular complications. This study presents a case of a patient with a complicated proximal phalangeal fracture who pursued digit salvage.
A 31-year-old Hispanic woman sustained severe injury to her right fifth digit during an all-terrain vehicle (ATV) rollover resulting in an exposed, comminuted fracture of the proximal phalanx with extensive structural and neurovascular compromise. She pursued digit salvage despite a high risk of failure and complication. The patient underwent four operations over a six-month period, …
Barriers To Implementing Comprehensive Sexuality Education As A Strategy To Prevent Adolescent Pregnancy In Indramayu District, Indonesia, Een Kurnaesih, Chahya Kharin Herbawani, Nelly Febriani
Barriers To Implementing Comprehensive Sexuality Education As A Strategy To Prevent Adolescent Pregnancy In Indramayu District, Indonesia, Een Kurnaesih, Chahya Kharin Herbawani, Nelly Febriani
Kesmas
The implementation of comprehensive sexuality education (CSE) is not optimal. This qualitative study aimed to identify and contextualize barriers to CSE implementation, specifically in Indramayu District, Indonesia. Conventional content analysis procedures were used. Seven participants, consisting of relevant authorities, were interviewed. A purposive sampling technique was employed to select participants. Data were collected through in-depth, semi-structured interviews. All interviews were recorded and transcribed verbatim. Data were analyzed using conventional qualitative content analysis. The barriers to CSE implementation in Indramayu District were identified across five themes: advocacy, technical considerations, coordination and collaboration, integration with other sexual and reproductive health projects, and …
Experiences Of Elderly Living With Noncommunicable Diseases In Utilizing Health Services In Myanmar During The Covid-19 Pandemic, Nway Eint Chei, Kwanjai Amnatsatsue, Natkamol Chansatitporn, Ariya Bunngamchairat
Experiences Of Elderly Living With Noncommunicable Diseases In Utilizing Health Services In Myanmar During The Covid-19 Pandemic, Nway Eint Chei, Kwanjai Amnatsatsue, Natkamol Chansatitporn, Ariya Bunngamchairat
Kesmas
The COVID-19 pandemic and armed conflicts in Myanmar have intensified the challenges in accessing and utilizing health services, particularly for noncommunicable diseases (NCDs) among older adults. This qualitative study explored the experiences of the elderly with NCDs regarding health service accessibility and utilization in secure areas with fully operational health facilities by conducting in-depth interviews with 20 eligible older adults in Myanmar; data were analyzed using content analysis. Four key themes emerged: NCD service utilization patterns; unmet needs; preferences and hesitancy toward NCD services; and disparities, barriers, and opportunities. The findings revealed widespread underutilization of NCD services due to several …
Low Economic Level And The Risk Of Overweight Among Indonesian Junior And Senior High School Students, Ariyanto Nugroho, Purwo Setiyo Nugroho, Amarin Yudhana, Sri Sunarti
Low Economic Level And The Risk Of Overweight Among Indonesian Junior And Senior High School Students, Ariyanto Nugroho, Purwo Setiyo Nugroho, Amarin Yudhana, Sri Sunarti
Kesmas
Overweight and obesity among Indonesian adolescents have emerged as a pressing public health issue, reflecting global trends. This study examines the relationship between economic status and overweight prevalence among junior and senior high school students in Indonesia, using secondary data from the Global School-based Health Survey (GSHS). This study analyzed data from 9,977 students aged 11–18 years through a cross-sectional design and binary logistic regression, adjusting for dietary habits, physical activity, and sedentary behavior. Overall, 14.7% of students were overweight; the prevalence was notably higher among low-income students (27.4%) compared to high-income groups (14.2%). Students from lower economic backgrounds were …
Government Health Spending And Life Expectancy: Evidence From Cities And Districts In Indonesia, Kurnia Sari, Budi Hidayat, Amal Chalik Sjaaf, Mardiati Nadjib
Government Health Spending And Life Expectancy: Evidence From Cities And Districts In Indonesia, Kurnia Sari, Budi Hidayat, Amal Chalik Sjaaf, Mardiati Nadjib
Kesmas
Life expectancy is widely recognized as a fundamental indicator of population health, and its improvement is often linked to government health spending, particularly in decentralized health systems. This study aimed to investigate the relationship between local government health expenditures and life expectancy in decentralized Indonesia. Data from 492 cities and districts, spanning from 2015 to 2019, were analyzed using a two-way fixed effects regression model to control for time-invariant district characteristics and common temporal shocks. The findings indicated that a 10% increase per capita in government health expenditure was associated with a 0.01% increase in life expectancy. This association was …
Hurricane Katrina Archive: Faculty Publications Bibliography 2010-2014, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse
Hurricane Katrina Archive: Faculty Publications Bibliography 2010-2014, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse
LSUHSC Hurricane Katrina Archive: Bibliographies
This bibliography includes 45 articles about Hurricane Katrina written by authors affiliated with LSU Health – New Orleans between January 2010 and December 2014.
Hurricane Katrina Archive: Faculty Publications Bibliography 2005-2009, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse
Hurricane Katrina Archive: Faculty Publications Bibliography 2005-2009, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse
LSUHSC Hurricane Katrina Archive: Bibliographies
This bibliography includes 91 articles about Hurricane Katrina written by authors affiliated with LSU Health – New Orleans between January 2005 and December 2009.
Staff Education On The Abbreviated Teachers’ Rating Scale (Atrs) Tool As A Screening Tool For Attention Deficit Hyperactivity Disorder (Adhd)., Tena E. Currie
Staff Education On The Abbreviated Teachers’ Rating Scale (Atrs) Tool As A Screening Tool For Attention Deficit Hyperactivity Disorder (Adhd)., Tena E. Currie
Walden Dissertations and Doctoral Studies
This doctoral project is a staff education program to enhance the treatment and diagnosis of attention-deficit hyperactivity disorder (ADHD) at a mental healthcare facility. The identified practice problem was the lack of knowledge about the Abbreviated Teacher Rating Scale (ATRS) used in ADHD testing, which may result in inaccuracies and underutilization of the tool. To bridge this gap is essential in nursing practice as clinicians should be competent in performing standard assessment, which is indispensable for patient with ADHD. Staff education with the ATRS was the practice-directed question for the project: Does staff education with the ATRS increase knowledge for …
Adapt-3d: Accelerated Deep Adaptable Processing Of Tissue For 3-Dimensional Fluorescence Tissue Imaging For Research And Clinical Settings, Daniel D Lee, Kevin A Telfer, Deanna L Davis, Leon C D Smyth, Rahul Ravindran, Rafael S Czepielewski, Christopher G Huckstep, Siling Du, Kento Kurashima, Ajay K Jain, Jonathan Kipnis, Bernd H Zinselmeyer, Gwendalyn J Randolph
Adapt-3d: Accelerated Deep Adaptable Processing Of Tissue For 3-Dimensional Fluorescence Tissue Imaging For Research And Clinical Settings, Daniel D Lee, Kevin A Telfer, Deanna L Davis, Leon C D Smyth, Rahul Ravindran, Rafael S Czepielewski, Christopher G Huckstep, Siling Du, Kento Kurashima, Ajay K Jain, Jonathan Kipnis, Bernd H Zinselmeyer, Gwendalyn J Randolph
2020-Current year OA Pubs
Light sheet microscopy and preparative clearing methods that improve light penetration in 3D tissues have revolutionized imaging in biomedical research. Here we present ADAPT-3D, a streamlined 3-step approach to turn tissues optically transparent while preserving tissue architecture with the versatility to handle diverse tissue sizes and types across species. Unlike extensive lipid removal utilized by existing protocols, ADAPT-3D only partially removes lipids to preserve cell membranes, yet the non-toxic aqueous refractive indexing solution still rapidly turns tissues transparent while preserving the fluorescence of endogenous and antibody conjugated fluorophores. ADAPT-3D prepares whole mouse brains for light sheet microscopy in a 4-hour …
Whf Roadmap On Single Pill Combination Therapies, Enrico G Ferro, Mark Huffman, Orly Vardeny, Et Al.
Whf Roadmap On Single Pill Combination Therapies, Enrico G Ferro, Mark Huffman, Orly Vardeny, Et Al.
2020-Current year OA Pubs
Cardiovascular diseases (CVDs) are the leading global cause of mortality, with treatment adherence posing a major barrier to effective prevention and control. Single pill combinations (SPCs), also known as fixed-dose combinations, simplify treatment by combining multiple agents into one pill, improving adherence and reducing cardiovascular risk. This World Heart Federation Roadmap synthesizes the latest clinical evidence and identifies key barriers to SPC implementation, including limited manufacturing, affordability, regulatory complexity, and inconsistent guideline inclusion. Drawing on global expert input and health systems analysis, the Roadmap outlines practical, context-specific solutions to improve access, scale-up, and integration of SPCs into national strategies, especially …
Excitotoxic Neuronal Death Requires Superoxide Entry Into Neurons Through Volume-Regulated Anion Channels, Kate Harris, Seok Joon Won, Gokhan Uruk, Nguyen Mai, Devran Ogut, Yonghui Zhao, Litao Xie, Paul Baxter, Katharina Everaerts, Rajan Sah, Raymond A Swanson
Excitotoxic Neuronal Death Requires Superoxide Entry Into Neurons Through Volume-Regulated Anion Channels, Kate Harris, Seok Joon Won, Gokhan Uruk, Nguyen Mai, Devran Ogut, Yonghui Zhao, Litao Xie, Paul Baxter, Katharina Everaerts, Rajan Sah, Raymond A Swanson
2020-Current year OA Pubs
Neuronal death in stroke and other conditions stems in part from stimulation of
Prefoldin Complex Promotes Interferon-Stimulated Gene Expression And Is Inhibited By Rotavirus Vp3, Yinxing Zhu, Yanhua Song, Dilip Kumar, Peter K Jackson, B V Venkataram Prasad, Siyuan Ding
Prefoldin Complex Promotes Interferon-Stimulated Gene Expression And Is Inhibited By Rotavirus Vp3, Yinxing Zhu, Yanhua Song, Dilip Kumar, Peter K Jackson, B V Venkataram Prasad, Siyuan Ding
2020-Current year OA Pubs
Timely induction of interferons and interferon-stimulated genes (ISGs) is critical for successful host defense against viral infections. VP3 encoded by rotavirus is implicated in interferon antagonism. However, the precise mechanisms remain incompletely understood. By conducting tandem-affinity purification coupled with high-resolution mass spectrometry, we identify the prefoldin complex as the top cellular binding partner of VP3. Rotavirus infection is significantly enhanced in prefoldin subunit knockout cells. Using proteome-wide label-free quantification, we find that prefoldin assists in folding ubiquitin-like-modifier-activating-enzyme-3 (UBA3), both of which positively regulate ISG expression. Through direct and competitive binding, VP3 interferes with the chaperone activity of prefoldin, leading to …
The Caribbean American Dementia And Aging Study: Protocol For A Population-Based Study Of Older Adult Health And Dementia In Cuba, The Dominican Republic, And Puerto Rico, Mao-Mei Liu, Jorge Llibre-Guerra, Chris Soria, Jing Li, Tania Zayas Llerena, Guillermina Rodriguez, Daisy Acosta, Ivonne Jiménez Velázquez, Juan J Llibre-Rodriguez, William H Dow
The Caribbean American Dementia And Aging Study: Protocol For A Population-Based Study Of Older Adult Health And Dementia In Cuba, The Dominican Republic, And Puerto Rico, Mao-Mei Liu, Jorge Llibre-Guerra, Chris Soria, Jing Li, Tania Zayas Llerena, Guillermina Rodriguez, Daisy Acosta, Ivonne Jiménez Velázquez, Juan J Llibre-Rodriguez, William H Dow
2020-Current year OA Pubs
BACKGROUND: The Hispanic Caribbean region is rapidly aging but national population-based aging surveys are rare. The Caribbean American Dementia and Aging Study (CADAS) is a multi-purpose household study of aging with a particular focus on the life course determinants and consequences of health and dementia in three countries with many similarities but divergent recent histories: Puerto Rico, Dominican Republic, and Cuba. METHODS: CADAS will survey population-based samples of adults ages 65 and over. In Puerto Rico and Dominican Republic these will be nationally representative samples of 1,500 adults each; the Cuban survey will include 1,500 adults from purposively selected urban …
Dynamics And Malleability Of Plant Dna Methylation During Abiotic Stresses, Niraj Lodhi, Rakesh Srivastava
Dynamics And Malleability Of Plant Dna Methylation During Abiotic Stresses, Niraj Lodhi, Rakesh Srivastava
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Epigenetic regulation, particularly DNA methylation, plays a crucial role in plant adaptation to environmental stresses by modulating gene expression without altering the underlying DNA sequence. In response to major abiotic stresses such as salinity, drought, heat, cold, and heavy metal toxicity, plants undergo dynamic changes in DNA methylation patterns. These modifications are orchestrated by DNA methyltransferases and demethylases with variations depending on plant species, genetic background, and ontogenic phase. DNA methylation affects the expression of key genes involved in cellular, physiological, and metabolic processes essential for stress tolerance. Furthermore, it contributes to the establishment of stress memory, which can be …
Governance Of Polygenic Embryo Screening: A Qualitative Study On The Perspectives Of Clinicians And Patients, Jason Bach, Jonathan Frumovitz, Dorit Barlevy, Rémy A Furrer, Abigail Martinez, Ana Battaglino, Shai Carmi, Todd Lencz, Gabriel Lázaro-Muñoz, Stacey Pereira
Governance Of Polygenic Embryo Screening: A Qualitative Study On The Perspectives Of Clinicians And Patients, Jason Bach, Jonathan Frumovitz, Dorit Barlevy, Rémy A Furrer, Abigail Martinez, Ana Battaglino, Shai Carmi, Todd Lencz, Gabriel Lázaro-Muñoz, Stacey Pereira
Center for Medical Ethics and Health Policy Staff Publications
Objective: To investigate the perspectives of stakeholders on their attitudes toward potential regulation of polygenic embryo screening (PES), a new form of preimplantation genetic testing that is used to screen embryos for the genetic chances of developing medical conditions and nonmedical traits involving hundreds or thousands of genes.
Design: We conducted individual, semistructured interviews and analyzed transcripts using thematic analysis.
Subjects: Twenty-seven US-based reproductive endocrinology and infertility specialists and 26 patients who were currently undergoing in vitro fertilization or had within the past five years.
Main outcome measures: Repeating ideas and patterned responses were organized into themes and subthemes.
Results: …
Empowering Youth Tackle Football Athletes: A Content Analysis Of Nonlinear Pedagogy’S Influence On Autonomy And Practical Applications In Youth Tackle Football, Benjamin Jay Andelman
Empowering Youth Tackle Football Athletes: A Content Analysis Of Nonlinear Pedagogy’S Influence On Autonomy And Practical Applications In Youth Tackle Football, Benjamin Jay Andelman
Masters Theses
Youth tackle football offers an environment that promotes both positive mental and physical benefits for young athletes. Despite the positive benefits associated with sports, participation is on the decline. The content analysis found connections between the prevailing prescriptive coaching methods in youth tackle football and the adverse mental effects on young athletes. This study, utilizing a qualitative content analysis of existing academic literature, proposes a practical application of Nonlinear Pedagogical principles in the youth tackle football practice context to develop a coaching model that promotes athlete autonomy, thereby increasing positive mental benefits for the youth athlete. Leveraging Ecological Dynamics, Constraints-Led …
Has Regional Hospital Autonomy Achieved Its Goals? Lessons Learned From Indonesia: A Systematic Review, Masyitoh Basabih, Indriaswari Widhakuswara
Has Regional Hospital Autonomy Achieved Its Goals? Lessons Learned From Indonesia: A Systematic Review, Masyitoh Basabih, Indriaswari Widhakuswara
Kesmas
This study examined the impact of hospital autonomy implementation on the performance of regional public hospitals in Indonesia, particularly in terms of efficiency, effectiveness, and governance. A systematic review of 32 peer-reviewed studies published between June 12 and September 6, 2023, was conducted using Garba Rujukan Digital and Google Scholar, following PRISMA guidelines. Studies addressing financial performance, service outcomes, and challenges related to implementing autonomy were included. The findings indicated that while autonomy led to improvements in infrastructure, service types, visit volumes, and hospital revenues, it had only a marginal impact on improving key health performance outcomes, such as service …
Risk Of Major Depression In Partners Of People With Alzheimer's Disease: A National Cohort Study, Casey Crump, Jingkai Wei, Barbara G Vickrey, Alexis C Edwards, Paul E Schulz, Weiva Sieh, Jan Sundquist, Kristina Sundquist
Risk Of Major Depression In Partners Of People With Alzheimer's Disease: A National Cohort Study, Casey Crump, Jingkai Wei, Barbara G Vickrey, Alexis C Edwards, Paul E Schulz, Weiva Sieh, Jan Sundquist, Kristina Sundquist
Faculty, Staff and Student Publications
Background: Alzheimer's disease (AD) may cause significant psychosocial distress not only in the patient but also their partner. However, long-term risks of major depression in partners of AD patients are largely unknown.
Methods: A national cohort study was conducted of all 145 289 partners of people diagnosed with all-cause dementia, including 57 113 partners of people diagnosed with AD, in Sweden during 1998-2017, and 1 300 561 population-based controls. Cox regression was used to compute hazard ratios (HRs) for subsequent risk of major depression identified from nationwide outpatient and inpatient diagnoses through 2018, adjusting for sociodemographic factors and prior mental …
Exploring The Effectiveness Of Wearable Devices For Early Disease Detection, Chinonso Iwummadu
Exploring The Effectiveness Of Wearable Devices For Early Disease Detection, Chinonso Iwummadu
Doctoral Dissertations and Projects
The purpose of this qualitative interpretive phenomenological study was to explore the perceived effectiveness of wearable devices in facilitating early disease detection among patient groups, healthcare professionals, and healthcare administrators in the outpatient care setting. The central phenomenon investigated, involved the experiences, perceptions, and behavioral responses toward real-time monitoring and diagnostic engagement enabled by wearable devices. The theory that guided the study was the Health Technology Acceptance Model (HTAM), which supported inquiry into how perceived usefulness, perceived ease of use, and perceived health outcomes shaped adoption behavior and clinical integration of digital tools. Data were collected from a purposive sample …
Epigenetic Modulation Of Bard1 To Enhance Anti-Vegf Therapy, Emine Bayraktar, Cristian Rodriguez-Aguayo, Elaine Stur, Sudhir Kumar, Lingegowda S Mangala, Nicholas B Jennings, Nazende Nur Bayram, Sara Corvigno, Amma Asare, Cristina Ivan, Mark S Kim, Thanh Chung Vu, Pahul Hanjra, Sangbae Kim, Adrian Lankenau Ahumada, Weichem Wu, Sanghoon Lee, Anna Szymanowska, Hulya Oztatlici, Marcos R Estecio, Ju-Seog Lee, Abhinav K Jain, Nidhi Sahni, John P Hagan, Stephen Baylin, Jinsong Liu, Gabriel Lopez-Berestein, Sunila Pradeep, Anil K Sood
Epigenetic Modulation Of Bard1 To Enhance Anti-Vegf Therapy, Emine Bayraktar, Cristian Rodriguez-Aguayo, Elaine Stur, Sudhir Kumar, Lingegowda S Mangala, Nicholas B Jennings, Nazende Nur Bayram, Sara Corvigno, Amma Asare, Cristina Ivan, Mark S Kim, Thanh Chung Vu, Pahul Hanjra, Sangbae Kim, Adrian Lankenau Ahumada, Weichem Wu, Sanghoon Lee, Anna Szymanowska, Hulya Oztatlici, Marcos R Estecio, Ju-Seog Lee, Abhinav K Jain, Nidhi Sahni, John P Hagan, Stephen Baylin, Jinsong Liu, Gabriel Lopez-Berestein, Sunila Pradeep, Anil K Sood
Faculty, Staff and Student Publications
Despite the clinical use of anti-vascular endothelial growth factor (VEGF) antibodies (AVAs) in cancer therapy, resistance frequently develops, leading to disease progression. To address this, we identify a previously unknown role for breast cancer type 1 susceptibility protein (BRCA1)-associated RING domain 1 (BARD1) in modulating AVA sensitivity. Epigenetic modulation-via global and targeted DNA methylation-reveals BARD1 as a key regulator of angiogenesis. Sequential treatment with azacytidine overcomes AVA resistance in vivo. To enable precise epigenetic reactivation, we develop a liposomal CRISPR-deactivated Cas9 (dCas9)-TET1 system guided by BARD1-targeting single-guide RNAs (sgRNAs). This platform achieves CpG-specific demethylation of the BARD1 promoter, restores expression, …
Ras-Membrane Interaction And Oligomerization: There Is More Than Meets The Eye, Abraham C Sianoya, Vijay K Bhardwaj, Alemayehu A Gorfe
Ras-Membrane Interaction And Oligomerization: There Is More Than Meets The Eye, Abraham C Sianoya, Vijay K Bhardwaj, Alemayehu A Gorfe
Faculty, Staff and Student Publications
Membrane association is fundamental to Rat sarcoma (RAS) function, driving both its physiologic signaling and oncogenic transformation. This review consolidates recent advances in the study of RAS-membrane interactions, emphasizing the molecular mechanisms underlying its membrane engagement and oligomerization. We first discuss the roles of RAS lipid modification and conformational diversity of its intrinsically disordered C-terminus in these processes, and we then examine the debate surrounding RAS dimerization and its potential role in the formation of higher-order oligomers. By integrating emerging insights into these issues, we offer our own perspectives on the driving forces of RAS oligomerization and propose potential new …
Investigating The Practice Of A Somatic, Mindful Christian Prayer And Breathing Practice On Public Speaking Anxiety, Robyn L. Middleton
Investigating The Practice Of A Somatic, Mindful Christian Prayer And Breathing Practice On Public Speaking Anxiety, Robyn L. Middleton
Doctoral Dissertations and Projects
This randomized controlled trial investigated the effectiveness of a mindful Christian prayer practice (The Jesus Prayer) combined with slow diaphragmatic breathing on communication anxiety. Participants (N = 80) included university students and members of the general public aged 18-60 who experience public speaking anxiety. Measurements included self-reported speech anxiety and heart rate variability (assessed via the WellHero app). Repeated measures ANOVAs revealed that the mindful prayer practice had no significant effect on participants' self-reported speech anxiety or RMSSD heart rate variability. A statistical trend of lower Baevsky’s Stress Index (another variable WellHero provided) was observed in the intervention group. This …
Associations Between Factors Of Unhealthy Lifestyle, Mental Health Issues, Chronic Illnesses, Environmental Health Risks, And Infertility In Females: A Cross-Sectional Study, Richard L. Huang
Doctoral Dissertations and Projects
Infertility has risen rapidly in recent decades and has become the third-largest public health concern in the world. It has significantly threatened individuals’ psychological, physical, and social well-being, and it could be an early sign of severe health problems in the future. Furthermore, it also threatens the continuation of life and human civilization. The purpose of this study was to examine the relationship between individuals’ daily lifestyle behaviors, mental health status, chronic conditions, environmental health factors, and infertility by using cross-sectional quantitative methods. It benefits the public as the study raised awareness of potential risks and provided guidance to avoid …
Beyond The Screening: Enhancement Of The Patient Experience Through Biophilic Interventions In A Controlled Mammography Environment, Sarah J. Morris
Beyond The Screening: Enhancement Of The Patient Experience Through Biophilic Interventions In A Controlled Mammography Environment, Sarah J. Morris
Doctoral Dissertations and Projects
This study was intended to significantly contribute to the body of research focused on biophilic design within the healthcare setting while expanding the application to the diagnostic imaging setting. This study’s purpose was to improve the mammography experience through the implementation of biophilic design for the enhancement of the patient experience, while successfully reducing negative perceptions during mammography procedures. The intervention of biophilic design has been shown to positively impact relaxation, wellness, and health through the reduction of stress. A randomized controlled trial with utilization of a quantitative design was utilized for the collection of data on the patient experience. …